Top 50 Biotechnology Startup Investors in United States (November 2026)

Portfolio highlights

• Halla — Halla Intelligence is a digital solution that leverages over 100 billion shopper and product data points to recommend and promote what grocery items.
• Verdex Technologies — Verdex Technologies is an advanced materials platform technology that uses nanofibers to disrupt industries. Verdex doesn't just compete, it innovates and disrupts.
• Samphire Neuroscience — Samphire Neuroscience builds clinically validated neurotechnology to support women across their lives. Our wearable devices, Nettle™ and Lutea™, are built on the same underlying brain-stimulation technology, targeting neural pathways involved in pain, mood, stress, and sleep regulation. - Lutea™ is available globally as a wellness device. Itstimulates the same regions of the brain to support stress regulation, sleep, and recovery - key drivers of readiness and long-term performance - allowing athletes and teams to move beyond wellbeing education alone to practical, evidence-based intervention. - Nettle™ is a CE-marked (EU and UK regulated), drug- and hormone-free device that has been clinically shown to improve pain, mood, functionality, and the ability to train during the menstrual cycle, with measurable benefits after one month of use - supporting athletes to maintain training intensity and movement quality during their period. - The Samphire App is the platform controlling all Samphire hardware products with the use of CycleSync™ AI technology: the only one of its kind to support personalized neurotechnology use for women.

Portfolio highlights

• FluoSphera — Fluosphera better predicts the effects of molecules through animal-free microphysiological systems, helping you to discover more efficient drugs with less adverse side effects.
• Giraffe Bio — Giraffe Bio uses AI and biomolecules to optimize metal extraction, increase yield, and reduce environmental impact. Revolutionizing sustainable mining technology.
• Transition Metal Solutions — Transition harnesses wild microbial communities to recover copper and other critical metals from low-grade mining resources.

Portfolio highlights

• Oratomic — Oratomic is a Pasadena-based quantum computing company building fault-tolerant quantum computers with neutral atoms.
• Synchron — The endovascular brain computer interface.
• Soufflé Therapeutics — Soufflé Therapeutics is a biotechnology company specializing in the development of nucleic acid medicines designed for precise delivery and targeting of disease-causing cells. The company's mission is to create potent, precise, and safe medicines that can be tailored for a broad range of diseases by leveraging breakthroughs in genetic medicineand drug delivery technology.

Portfolio highlights

• Leal Therapeutics — Leal Therapeutics develops novel therapeutics for patients.
• BigHat Biosciences — We use machine learning and synthetic biology to design and engineer antibody therapeutics.
• Khartis Therapeutics — Khartis is a drug discovery company developing oral therapies for patients with immune-mediated and chronic diseases. The company focuses on discovering and developing drug candidates intended to address chronic conditions and immune-mediated diseases.

Portfolio highlights

• CoGenesys — CoGenesys is a biopharmaceutical company focused on the development of peptide- and protein-based medicines. The company develops peptide and protein-based medicines for cancer, cardiovascular, metabolic, infectious, autoimmune, and CNS diseases.
• InventisBio — InventisBio is a biotech company whose product pipeline includes small molecule drug candidates for targeted therapies in lung cancer, breast cancer and gout. The company is also actively developing drugs that can be combined with other immune-oncology targeted therapies, such as PD-1 antibody, for various cancer indications. The company isco-founded by Dr. Yaolin Wang and other scientists who have previously worked at Merck and Schering-Plough, leading various drug discovery projects in oncology, metabolic and infectious disease areas.
• Bonovo Orthopedics —

Portfolio highlights

• NextDroid — NextDroid - We're Doing Something Different
• Hello Patient — Healthcare AI that gets your team off the phone & in front of patients
• Alva Energy — Alva Energy is a nuclear solution based firm that aids challenges related to nuclear power offering on time delivery of nuclear megawatts.

Portfolio highlights

• E Ink — E Ink Corp. is a supplier of electronic paper display (EPD) technologies. Products made with E Ink's electronic ink are designed to possess a paper-like high contrast appearance, ultra-low power consumption, and a thin, light form. E Ink's technology is tailored for many consumer and industrial applications including handheld devices, watches, clocks, and public information and promotional signs.
• Songbird — DropCatch.com helps you secure expiring domain names.
• Ethyreal Bio — Ethyreal Bio is an early-stage biotechnology company developing precision, mechanism-driven therapies for thyroid diseases with high unmet medical needs.

Portfolio highlights

• Uhana — Modernize your RAN to be open and programmable, built with a rich ecosystem of partners. Learn about VMware RAN Intelligent Controller (RIC).
• erytech — ERYtech Pharma, set up in Lyon (France) in 2004, specializes in the encapsulation of therapeutic molecules and enzymes in red blood cells. It has achieved a major breakthrough in the fields of cancer and enzyme therapy by significantly increasing the therapeutic index of the encapsulated molecule or enzyme.
• Sportsrocket — Sportsrocket is a New York-based company working to give sports fans access to live games and events, highlights, and shows. The company works with leading leagues, publishers, and rights-holders, including Major League Soccer, the PGA Tour, Scout Media, and AS Roma, to create and power customized OTT platforms. Incubated by Bedrocket Media Ventures, Sportsrocket's innovative approach is based on a proprietary sports media operating system, that offers an integrated solution for the production, distribution, management, and monetization of sports media across all platforms.

Portfolio highlights

• ice — Ice.com is one of the leading e-commerce website that sells diamonds, engagement rings, watches, earrings and all other types of jewelry. It raised $47 million from Polaris Venture Partners and Ignition Partners. The online retailer opened its doors in 1999 and has grown to annual sales of $83.4 million.
• Living Proof — Living Proof was created for the purpose of applying advanced technology to solve the toughest beauty challenges from a completely fresh perspective. They are a team of scientists from outside beauty, led by MIT Institute Professor Dr. Bob Langer, and beauty authorities with a shared vision: to invent efficient formulas based on entirely newmolecules and breakthrough technologies for results you can see from across the room.
• Cushcraft Corp. — Cushcraft Corp. designs, develops, manufactures, and distributes antennas and other passive radio frequency (RF) products for broadband wireless, communications, and data connectivity solutions.

Portfolio highlights

• Tennr — Tennr is a custom AI assistant that accelerates research, answers complex questions, and generates custom reports.
• ngmoco — ngmoco ("Next Generation MObile COmpany") is creating and producing games for the iPhone. CEO Neil Young is a former executive from Electronic Arts, where he oversaw the development of several hit titles. Another EA vet and partner at Kleiner Perkins, Bing Gordon, sits on the board. Kleiner is an investor through its iFund.
• SolveAI —

Portfolio highlights

• Seeo — Daftar akun togel resmi bisa melalui via dana, ovo, gopay, linkaja kami juga menyediakan berbagai link togel terpercaya seperti bo togel hadiah 2d 200rb, bandar togel hadiah 4d 10 juta terpercaya, situs togel resmi dan terpercaya, agen togel terpercaya, daftar bandar togel terbesar dan terpercaya, bandar togel terbesar, situs togel prize 123, bo togel bolak balik dibayar dan banyak lainnya yang kami sediakan untuk pencinta link togel resmi di Indonesia.
• Anrok — Anrok automates sales tax compliance across your financial stack, so you can grow your SaaS business in any market.
• LanzaTech — LanzaTech offers a technology platform that transforms industrial waste gases such as carbon monoxide and carbon dioxide into valuable chemical intermediates and fuels through microbial gas fermentation. The company’s process captures emissions from heavy-industry sources and uses specialized microbes to convert those gases into ethanol, which is then refined into materials such as monoethylene glycol for packaging, solvents, proteins, and sustainable aviation fuels. LanzaTech integrates its bioconversion system with industrial emitters, enabling the reuse of carbon streams that would otherwise be released into the atmosphere, and supplies downstream manufacturers in sectors including packaging, textiles, and aviation with fossil-alternative feedstocks.

Portfolio highlights

• Serapha Bio —
• Windward Bio — Windward Bio is a clinical-stage, drug development company committed to improving outcomes for people living with serious immunological diseases.
• Lisata Therapeutics — Lisata is a clinical-stage pharmaceutical company dedicated to improving lives through the discovery, development, and commercialization of innovative medicines.

Portfolio highlights

• Flare Therapeutics — Flare Therapeutics is a biotechnology company opening up a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders, Flare’s team has uncovered ‘switch sites,’ druggable regions that are key targets fortranscription factor regulation to address mutations that cause disease. Its drug discovery to target switch sites has rapidly advanced, resulting in an emerging pipeline of drug programs that address well-validated transcription factors, initially focused on precision oncology with future potential in neurology, rare genetic disorders, immunology, and inflammation.
• CytomX Therapeutics — CytomX Therapeutics is a biotechnology company that focuses on developing proteolytically-activated antibodies. Their mission, alone and with the help of partners, is to provide patients with more effective and less toxic therapies for severe illnesses such as cancer and inflammatory diseases.
• Lisata Therapeutics — Lisata is a clinical-stage pharmaceutical company dedicated to improving lives through the discovery, development, and commercialization of innovative medicines.

Portfolio highlights

• Innovent Biologics — Innovent Biologics, Inc. is a privately held biopharmaceutical company that is dedicated to the development and manufacturing of monoclonal antibodies to be marketed in China and elsewhere around the world. Innovent is funded by the venture arm of Fidelity, which is a major investment firm in the US, Lilly Ventures, and Suzhou bioBay. Theregistered capital is 30Million US Dollars. The founders and senior management team of Innovent have over 70 years of combined work experience in the discovery, development and manufacture of biologics in the US, Europe and worldwide and were involved in the launch of such products as Bexxar, Conbercept, Natrecor, Oncorine, Recombivax HB, and others.
• PlasmaGen Biosciences — PlasmaGen BioSciences is an Indian Bio-pharmaceutical organization specializing exclusively in Plasma Protein Therapy.Headquartered in Bangalore- India, PlasmaGen has been making every effort in the domain of Plasma product Industry and has become an Imperative one stop destination for the medical fraternity for most of the plasma products need.They have a basket of plasma products and the widest range of immunoglobulins in India catering to the requisites of various realms viz. Haematology, Oncology, Immunology, Paediatrics, Rheumatology, Dermatology and Neurology.
• Ultragenyx Pharmaceutical — Ultragenyx is focused on developing first-ever approved treatments for rare and ultrarare diseases and moving the rare disease community forward.

Portfolio highlights

• Nouscom — Nouscom is a next-generation immunotherapy company developing genetic cancer vaccines and oncolytic viruses..
• Gate Bioscience — Gate Bioscience is developing Molecular Gates, a new frontier in protein elimination. Molecular Gates are small molecule drugs that selectively eliminate harmful extracellular proteins at their origin, inside cells, and prevent them from emerging to cause disease.
• Dayra Therapeutics — Dayra Therapeutics manufactures peptide based medicines.

Portfolio highlights

• Allara — Allara is your all-in-one virtual care team for hormonal, metabolic & gynecological conditions such as PCOS and Endometriosis.
• North.cloud — Automate your enterprise-grade cloud finance with zero effort. Our AI reduces your cloud bill by 50% without any risk, contracts, or technical work.
• Uvi — Uvi provides infrastructure that serves as a context and reasoning layer for enterprise AI agents. The platform resolves internal corporate vocabulary, tracks dependencies, and reconstructs the decision-making intent scattered across disparate systems like Jira, GitHub, and Slack. By unifying data fragments into an integrated knowledge network, it enables AI tools to process query objectives accurately while enforcing existing user access permissions at the retrieval stage.

Portfolio highlights

• Tennr — Tennr is a custom AI assistant that accelerates research, answers complex questions, and generates custom reports.
• Stoïk — Stoïk is a cyber insurance company that integrates cybersecurity software with insurance protection, helping businesses manage their cyber risks effectively. Stoïk empowers brokers by offering clients comprehensive insurance policies and protection against cyber risks. Its mission is to equip brokers with the tools to help their clients insure andsafeguard against cyber threats.Stoïk's unique product simplifies the underwriting process using automated tests, replacing traditional questionnaires. It also provides continuous risk prevention through integrated cybersecurity tools and ensures swift, effective incident response with an in-house team of crisis management experts.
• Supersonik — Supersonik provides an AI-powered platform for SaaS companies to offer 24/7 interactive product demos, enabling prospects to explore and personalize demos instantly without scheduling or manual intervention.

Portfolio highlights

• Nouscom — Nouscom is a next-generation immunotherapy company developing genetic cancer vaccines and oncolytic viruses..
• Relypsa — Relypsa, Inc. is a privately-held, development stage biopharmaceutical company leading the discovery and development of novel non-absorbed polymeric drugs for important applications in cardiovascular and renal disease. Relypsa's lead product candidate is RLY5016, a non-absorbed potassium binder for the management of hyperkalemia. Relypsa isdedicated to discover additional product candidates through use of its proprietary polymer platform.
• Skye Bioscience — We are a biopharmaceutical company focused on the development of proprietary cannabinoid derivatives for the treatment of glaucoma and other diseases with significant unmet medical needs. Our innovative approach to drug development combines strong science with the drive to find solutions where the need is the greatest.

Portfolio highlights

• Orna Therapeutics — Orna Therapeutics is a biotechnology company dedicated to designing and delivering a new class of fully engineered circular RNA (oRNA) therapeutics with the potential to change the way we treat disease. Orna’s proprietary platform combines novel technology to create oRNAs that drive protein expression with validated and unique delivery solutions.
• Aratana Therapeutics — Aratana is uniquely positioned to deliver new, high-quality medicines to address unmet needs in companion animal care. We are committed to bringing world class science to animal health for companion animals and the people who care for them. Our competitive advantage resides in our ability to identify, acquire and develop high-value commercialproducts for companion animals in a cost effective and efficient manner.
• Rhythm Pharmaceuticals — Rhythm Pharmaceuticals is a global biopharmaceutical company committed to transforming the lives of patients with rare neuroendocrine diseases by rapidly advancing care and precision medicines that address the root cause.

Portfolio highlights

• HerdDogg — HerdDogg is a global herd health and data science platform. It is a two-part system that helps ranchers track health and proximity data from their herd. The company's device gathers the data captured by the ear tags and reports it directly to the rancher via an app or web database.
• Insignum AgTech — Insignum AgTech develops biotech plants that communicate with producers, alerting them to an illness in its early stages.
• Soiltech Wireless — Soiltech Wireless is a developer of ag-tech solutions to design electronic devices for agricultural professionals. Its product provides real-time data to drive efficiency and optimize quality. It also provides actionable data without installation hassles and creates scalable monitoring solutions for farmers.The company was founded in 2019 and isheadquartered in Rupert, Idaho.

Portfolio highlights

• Diligent Robotics — We build robots like Moxi that assist hospital staff with routine activities so they can focus on caring for patients.
• Setara Biosciences — Setara Biosciences combines deep expertise in Mendelian genetics, precision drug discovery, and data science to identify biologically validated targets for rare diseases with significant unmet needs targets that may also offer potential for treating more common conditions.
• GroundWork — GroundWork delivers Unified Monitoring for Real™ with an open software platform for shockingly easy integrations and customized visualizations of cloud, virtualization, network, application, server, and storage data.GroundWork Monitor is available in free (Core) and subscription versions with support (Enterprise).GroundWork was founded in 2004 andis headquartered in San Francisco, California with partners in Asia Pacific, Europe and South America.

Portfolio highlights

• Wafer — Wafer is an AI optimization platform that automatically accelerates AI models by generating efficient custom GPU kernels.
• Adaption Labs — Adaption is building adaptive intelligence that continually learns. Efficient, evolving AI for any industry or language.
• Multiply Labs — Multiply Labs develops robotic systems that manufacture small-batch drugs. Current pharma production methods are manual, slow, and costly. We believe that the only way to scale them is with cloud-controlled robots.

Portfolio highlights

• deets — deets Inc., is a Westport, Connecticut-based mobile technology company dedicated to improving people’s lives and productivity through meaningful, on-the-go sharing and collaboration solutions. Founded in 2011 by the former leadership of successful online companies including Priceline and Hotwire, deets launched its first product in 2012. ItsMobile and Web communication software dynamically synchronizes contacts and lets users manage group conversations and collaboration all from a single mobile dashboard. For more information on deets, please visit www.sharedeets.com.
• Umbie Health — Umbie Health Corporation, an East Hartford, Conn.-based that develops a Web-based and mobile practice management application for dentists.
• Axerion Therapeutics — Axerion Therapeutics, Inc. is a private Connecticut-based biotechnology company focused on developing innovative therapeutics for neurological diseases and injuries with significant unmet medical need, including Alzheimer’s disease and spinal cord injury.Axerion was established in New Haven to develop and commercialize intellectual propertylicensed from Dr. Stephen Strittmatter’s laboratory at Yale University. Axerion’s proprietary technology platforms include blockers of ß-amyloid (Aß) oligomers binding to Prion Proteins (PrP) on the cell surface of neurons as a novel therapeutic target for Alzheimer’s disease and Nogo Receptor decoy protein for recovery of neurological function in spinal cord injury and other neurological diseases.

Portfolio highlights

• Adimab — Premier Human Antibody Discovery and Optimization
• Reflex — The open-source framework to build and deploy web apps using Python.
• Cajal Neuroscience — Cajal Neuroscience is a drug discovery company focused on neurodegenerative disease.

Portfolio highlights

• CH4 Global — CH4 Global is an aquaculture solutions provider dedicated to urgently impacting climate change at scale. Lead by a world-class team of senior business builders, scientists and entrepreneurs, the company is initially leveraging proven science and technology for growing seaweed into innovative new livestock supplement that reduces methane produced bycows by up to 90%. Among early investors are a select group of prominent family offices and private investors. CH4 Global have also received non-dilutive capital support from government organizations from around the world. CH4 Global is a Delaware corporation based in Henderson, NV.
• Kairos Power — Building the future of clean energy through iterative development and vertical integration. Kairos Power's advanced reactors deliver reliable, safe nuclear power at scale.
• BioStack — BioStack Platforms develops data infrastructure and simulation environments for healthcare and drug discovery AI. The company builds proprietary preclinical and clinical data pipelines that connect longitudinal, multimodal medical data such as EHRs, imaging, ECGs, labs, notes, audio, and outcomes. It structures this information intomachine-learning-ready datasets and workflow-aligned simulation environments rather than static text corpora. These environments support post-training, reinforcement learning, and multi-agent reasoning for medical AI systems. BioStack Platforms serves AI labs, biotechnology startups, pharmaceutical teams, and data providers that need domain-specific datasets, causal inference support, and robust reward models. Its offerings are used to test, evaluate, and train medical AI models on real-world clinical workflows before deployment in practice.

Portfolio highlights

• Albedo — Aerial quality imagery - from space.
• Eden — Eden unifies medical imaging operations with clinical AI: PACS, teleradiology, AI-assisted diagnosis and structured reporting, deployed across 2,600+ imaging departments.
• Kivo Health — Kivo Health is a telehealth lung care company that provides rehab for chronic lung disease.

Portfolio highlights

• ZoomInfo — ZoomInfo is the #1 GTM Platform: Marketing and sales AI plus the best B2B data. All-in-one lead generation, prospecting, market intelligence , and ABM software.
• iris labs — Iris Labs is an AI company focused on improving human wellbeing through personalized AI experiences for self-awareness, and personal growth.
• Serif Bio­med­i­cines — Serif Biomedicines is pioneering Modified DNA as a new type of biotechnology. Serif combines nucleic acid chemistry, synthetic biology, delivery technology, and artificial intelligence to develop programmable, scalable, long-lasting, and redosable DNA therapies.

Portfolio highlights

• Kallyope — At TriGemX Bio, we are leveraging unique insights into neural signaling pathways and developing innovative medicines for the treatment of migraine.
• Hexagon Bio — Hexagon Bio is a data-driven biotech developing targeted small molecule therapeutics. Our proprietary platform combines data science and synthetic biology to discover and engineer drugs from DNA sequences. We are mining fungal genomes for inspiration for the next generation of targeted therapies for diseases with unmet needs.
• Circle Pharma — Circle Pharma is an early-stage biotechnology company applying proprietary computational design algorithms and innovative chemistry to develop cell-permeable macrocycle peptide therapeutics against important clinical targets. It does this through an iterative, rational design process that deploys large virtual libraries of conformationally diversemacrocycle scaffolds selected for inherent permeability. The company was founded by Matt Jacobson and Scott Lokey in 2012 and is headed by David J. Earp.

Portfolio highlights

• Latus Bio — Latus Bio focuses on developing innovative gene therapy candidates using precision delivery to enhance the lives of patients. Latus identified proprietary AAV capsids for clinical use. The company plans to administer low doses of its product candidates, aiming to improve clinical safety and manufacturing.
• Overwatch Health — Overwatch Health offers an AI-assisted virtual rehab for cardiac and pulmonary patients.
• Palvella Therapeutics — Palvella Therapeutics is a biopharmaceutical company focused on developing and commercializing novel therapies to treat patients living with serious, rare skin diseases and vascular anomalies for which there are no FDA-approved therapies.

Portfolio highlights

• Zag Bio — Zag Bio is harnessing the immune system in a whole new way by targeting the thymus to change treatment possibilities for millions of patients with autoimmune diseases.
• Skeletalis — Skeletalis is a biotechnology startup focused on developing next-generation precision medicines for musculoskeletal diseases, primarily osteoporosis.
• Tacit Therapeutics — Tacit Therapeutics created RNA-targeting treatments for devastating diseases. By repurposing pre-existing components of human cells, we have created the first broadly applicable and inherently non-immunogenic means to repair mutated genes. The company was founded in 2021 and is based in South San Francisco, California.

Portfolio highlights

• EdgeX — Edokonta builds software that allows hospitals to track mobile equipment, such as IV pumps and ultrasounds. The company was founded in 2018 and based in San Diego, California.
• Nested Knowledge — Nested Knowledge is designing an interface that allows you to examine the data from a comprehensive literature review on research questions of interest. The interactive, nested features facilitate therapeutic comparisons, assist with research organization, and allow physicians to compare nuances across patient characteristics and outcomes.
• Major Medical Devices — Major Medical Devices develops next-generation vascular devices for endovascular repair and related surgical procedures.

Portfolio highlights

• Dren Bio — Dren Bio is a biotechnology company with a portfolio of attractive projects focused on powerful protein engineering technologies for the depletion of cells, protein aggregates, and other disease-causing agents. It is a holding company business model aimed at creating value with multiple projects as stand-alone assets.
• Fragment — Fragment automates complex, exception-heavy procurement workflows with AI agents.
• Hello Patient — Healthcare AI that gets your team off the phone & in front of patients

Portfolio highlights

• Ascidian Therapeutics — Ascidian Therapeutics is a biotechnology company intended for medical use in medical and clinical gene therapy.
• Red Queen Therapeutics — Staying ahead of viral threats with new innovations in antiviral therapy
• Deep Apple Therapeutics — Deep Apple Therapeutics is discovering new small-molecule therapeutics with unprecedented speed and exceptional acumen.

Portfolio highlights

• Quantcast — We are taking an entirely new approach to advertising on the open internet.
• Coherence Neuro — Opto Biosystems specializes in the development of innovative healthcare technologies that bridge the gap between cancer neuroscience and bioelectronics. The company focuses on creating smaller, softer, and wireless biological interfaces designed to offer a new treatment modality. By leveraging advancements in neural engineering and bioelectronics,Opto Biosystems is dedicated to building new tools that interface with the body, aiming to improve patient outcomes in the healthcare sector. Their work includes exploring the stability of thin-film electrodes for neuromodulation, highlighting their commitment to advancing medical technology.
• Watchtower Labs — Watchtower Labs is an AI-first team with a single mission: to solve the most difficult technical obstacles in vital simulations and defense.

Portfolio highlights

• Kynexis — Kynexis is leading the way in precision medicine, focusing on the treatment of cognitive impairment associated with schizophrenia (CIAS). Explore our innovative approach and our dedication to improving the lives of millions globally.
• Visiogen — Visiogen, Inc. is an ophthalmic medical device company specializing in the development of new vision alternatives for patients with cataracts, with and without presbyopia. As part of this mission, Visiogen created the Synchrony dual optic accommodating *intraocular lens (IOL)* for use in the surgical treatment of these conditions.The device isdesigned to provide patients with near, intermediate and distance vision in a seamless continuum without the need for glasses or contact lenses. To eliminate lens handling during surgery, the Synchrony dual optic IOL is provided in a pre-loaded injector. This patented technology has been approved in Europe with a CE Mark designation and is currently undergoing clinical trials in the United States.
• Rein Therapeutics — Harnessing fibrosis, unleashing life

Portfolio highlights

• Flare Therapeutics — Flare Therapeutics is a biotechnology company opening up a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders, Flare’s team has uncovered ‘switch sites,’ druggable regions that are key targets fortranscription factor regulation to address mutations that cause disease. Its drug discovery to target switch sites has rapidly advanced, resulting in an emerging pipeline of drug programs that address well-validated transcription factors, initially focused on precision oncology with future potential in neurology, rare genetic disorders, immunology, and inflammation.
• Flexion Therapeutics — Flexion Therapeutics advances drug candidates through clinical proof of concept and beyond, in partnership with pharmaceutical and biotechnology companies. By providing expertise and sharing risk, Flexion effectively expands the portfolios of its partners.
• TwoStep Therapeutics — TwoStep Therapeutics is developing novel tumor-targeting therapeutics for solid tumors.

Portfolio highlights

• Ampaire — Ampaire is making flying more accessible to more people from more airports by developing electric aircraft that are safe, clean, quiet, and less costly.
• PlusPlus — PlusPlus provides a learning and development SaaS platform for technical professionals. It automates the management of onboarding, workshops, and tech-talks at scale. With PlusPlus, companies attract and develop employees.
• Magnetic Insight — Magnetic Insight (MI) introduced magnetic particle imaging into the preclinical diagnostic research market enabling quantitative cell tracking, imaging of vascular function, detecting metastatic tumors, visualizing inflammation, CAR-T cell therapies and initial research into regenerative medicine.

Portfolio highlights

• Multiply Labs — Multiply Labs develops robotic systems that manufacture small-batch drugs. Current pharma production methods are manual, slow, and costly. We believe that the only way to scale them is with cloud-controlled robots.
• Flare Therapeutics — Flare Therapeutics is a biotechnology company opening up a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders, Flare’s team has uncovered ‘switch sites,’ druggable regions that are key targets fortranscription factor regulation to address mutations that cause disease. Its drug discovery to target switch sites has rapidly advanced, resulting in an emerging pipeline of drug programs that address well-validated transcription factors, initially focused on precision oncology with future potential in neurology, rare genetic disorders, immunology, and inflammation.
• Atrium Therapeutics — Atrium Therapeutics is a clinical-stage biotechnology company developing precision RNA medicines for rare genetic cardiomyopathies. It specializes in targeted, non-viral delivery of small interfering RNA (siRNA) directly to heart muscle, building on Avidity Biosciences' Antibody Oligonucleotide Conjugate (AOC) platform to overcome non-specific tissue challenges.

Portfolio highlights

• Neomorph — We engineer neomorphic protein surfaces to unlock targeted protein degradation.
• Setara Biosciences — Setara Biosciences combines deep expertise in Mendelian genetics, precision drug discovery, and data science to identify biologically validated targets for rare diseases with significant unmet needs targets that may also offer potential for treating more common conditions.
• SHINE Technologies — Discover SHINE Technologies' innovative approach to fusion technology, producing medical isotopes, recycling nuclear waste, and generating energy.

Portfolio highlights

• Bliss — Skip long waitlists and expensive therapy. Book licensed online therapists in multiple languages with culturally informed care.
• BatteryPool — BatteryPool offers battery charging solutions for EV fleets and commercial vehicles.
• Apriority Financial — In a system built for lenders, Apriority works for borrowers: no hidden lender fees, continuous rate monitoring, and we never sell your data.

Portfolio highlights

• Dren Bio — Dren Bio is a biotechnology company with a portfolio of attractive projects focused on powerful protein engineering technologies for the depletion of cells, protein aggregates, and other disease-causing agents. It is a holding company business model aimed at creating value with multiple projects as stand-alone assets.
• Cloverleaf Bio — Cloverleaf Bio | Developing a new class of RNA therapeutics to revolutionize cancer therapy.
• Breye Therapeutics — Breye Therapeutics, a Danish-based biopharmaceutical firm in the clinical stages, is working to provide cutting-edge oral treatments for the management of retinal vascular diseases.

Portfolio highlights

• Exciva — EXCIVA GmbH is a privately held biotech company focused on development of clinical stage therapeutics for various indications in neuropsychiatry.
• Molten Salt Solutions — Molten Salt Solutions: Lithium Isotope Enrichment for Advanced Nuclear Power
• Acta Pharmaceuticals — Acta Pharmaceuticals is a biotechnology company focused on developing new therapies for early intervention and prevention of Alzheimer's disease.

Portfolio highlights

• Ousia Pharma — Ousia Pharma is paving the way for novel therapeutic strategies using peptide-drug-conjugates
• Windward Bio — Windward Bio is a clinical-stage, drug development company committed to improving outcomes for people living with serious immunological diseases.
• Anaconda BioMed — Anaconda Biomed, headquartered in Barcelona, Spain, is among the world's most innovative early stage medical technology companies. The company was founded by Dr. Ofir Arad and Dr. Marc Ribó in 2015, and is developing the ANCD BRAIN™, a novel 3rd Generation Stented Aspiration Thrombectomy System for the treatment of Acute Ischemic Stroke (AIS).

Portfolio highlights

• RapidPulse — Explore RapidPulse for innovative stroke treatments and technologies. Book appointments or learn about our team and clinical trials.
• 410 Medical — 410 Medical has developed a simple, intuitive solution that allows a single healthcare provider to rapidly deliver fluid to critically ill patients, improving care, and saving lives. Their device allows fast set-up, improves resuscitation speed, minimizes provider fatigue, and frees providers to address other patient care issues simultaneously.This solution is particularly useful in pre-hospital settings and the emergency department and where speed is critical and resources may be limited.It was founded in 2013 and headquartered in Durham, North Carolina.
• Ladder Health — Expert speech, occupational, physical, and feeding therapy for children, right from home, with flexible virtual visits and a plan that fits real life.

Portfolio highlights

• Tennr — Tennr is a custom AI assistant that accelerates research, answers complex questions, and generates custom reports.
• Whizzo — Whizzo specializes in materials science-driven manufacturing of engineered fashion and technical textiles. Our expertise lies in creating and executing innovative textile blends tailored for applications across automotive, agriculture, medical textiles, and engineered fashion.
• Daletlabs — Dalet Labs is pioneering the future of e-commerce through Generative AI and visual product discovery. Its platform transforms AI-generated imagery into interactive shopping experiences featuring real, purchasable products. By combining creativity, personalization, and technology, Dalet Labs is redefining how consumers discover and shop for products.

Portfolio highlights

• ATDev — ATDev builds robotic mobility and assistive technology for older adults and people with disabilities
• Journey Live — Journey is shifting the way modern companies prioritize mental health. Our proactive, inclusive tools engage every employee, every day.
• Trio Pharmaceuticals — Trio Pharmaceuticals is a cancer therapeutics company that develops dual-action drugs for immunogenic tumors. These drugs directly stop tumor growth and selectively stop immunosuppression in the tumor without targeting the current immune checkpoint pathways. The company was founded in 2018 and is headquartered in San Diego, California.

Portfolio highlights

• Pilgrim — Pioneering a biologically enhanced future for humanity.
• Onyx Bio — Onyx traces multiomic patient trajectories across immune health, aging, and disease, built for precision medicine.
• The Biological Computing — Biological Black Box integrates biological neurons with artificial neural networks to develop a living computer.

Portfolio highlights

• Windward Bio — Windward Bio is a clinical-stage, drug development company committed to improving outcomes for people living with serious immunological diseases.
• SCHOTT Poonawalla — SCHOTT Poonawalla is a manufacturer of pharmaceutical containers, made of neutral glass tubing. The company provides parenteral packaging systems crafted from tubular glass, serving the pharmaceutical industry with a broad range of products including vials, pre-fillable syringes, ampoules, and cartridges.
• Vantia Therapeutics — Vantia Therapeutics is an emerging pharmaceutical company developing novel, small molecule drugs targeting large areas of unmet medical need. Its strong clinical pipeline includes VA106483 for nocturia and VA111913 for dysmenorrhoea, which directly target indications that together affect many millions of people, are poorly treated and representbillion dollar markets. Vantia's strategy is to develop its proprietary drug candidates through Phase II clinical testing and then commercialise through partnerships. The Company was founded in 2008 and is backed by specialist life science investors Novo A/S, SV Life Sciences and MVM Life Science Partners.

Portfolio highlights

• MiClient — Miclient are deal closure platform which was founded by experienced sales leaders who recognized the need for a new generation of complicated quote configuration, contract signing, renewal & payment collection at one place for SMEs, Lead Management System, B2B SaaS, CRM software, CPQ (Configure- Price- Quote)
• Healionics — Healionics aims to provide safer, more reliable means of bloodstream access for dialysis in patients with kidney failure.
• NuvOx Therapeutics — NuvOx Pharma is a clinical stage biotech company developing an innovative platform of oxygen therapeutics to treat life-threatening diseases where hypoxia plays a role.

Portfolio highlights

• My FLiiP — FLiiP is the gym management software trusted by gyms in Canada and beyond. It unifies CRM, member management, billing, a branded app, and AI on one platform, the smart way to grow your gym, not just manage it.
• Force Equals — Force Equals is a Multi Agent AI planning operating system for enterprise software, ai, and business project planning. Manage Idea flow, Portfolio, Define challenges, align your team, collaborate, uncover the hidden requirements, and seamlessly hand off to development, project management or procurement workflows.
• Corstasis Therapeutics — Esperion is dedicated to discovering, developing and commercializing innovative and combination medicines to reduce cardiovascular risk.