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Top 50 Biotechnology Startup Investors in United States in May 2026

A list of 50 angel investors and VC (Venture Capital) funds that invest in Biotechnology startups based in United states. We rank investors based on the number of investments they made in Biotechnology companies from United states. We update this investor list every month.

Top 50 Biotechnology Startup Investors in United States in May 2026

Investor Biotechnology United States investments
SOSV 124
ARCH Venture Partners 116
Alexandria Venture Investments 97
OrbiMed 83
Atlas Venture 71
New Enterprise Associates 67
Versant Ventures 64
Polaris Partners 62
Innova Memphis 62
Khosla Ventures 61
5AM Ventures 61
Third Rock Ventures 60
MPM Capital 60
RA Capital Management 56
F-Prime 55
BioAdvance 48
Canaan Partners 48
Andreessen Horowitz 46
Alumni Ventures 46
The Column Group 45
Novartis Venture Fund 43
KdT Ventures 43
Lux Capital 42
DCVC 41
Fifty Years 41
Connecticut Innovations 41
Google Ventures 40
Mission BioCapital 40
Hatteras Venture Partners 39
Dolby Family Ventures 38
Frazier Healthcare Partners 38
Pfizer Venture Investments 37
Sofinnova Investments 37
Life Science Angels 35
Northpond Ventures 35
Boston Harbor Angels 35
Novo Holdings 34
Civilization Ventures 34
Domain Associates 33
Omega Funds 33
Amgen Ventures 33
Founders Fund 32
Illumina Ventures 32
Refactor 32
North Carolina Biotechnology Center 31
Vivo Capital 31
Takeda Ventures 31
Flagship Pioneering 30
Digitalis Ventures 30
DCVC Bio 30

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SOSV
VC Fund · Princeton, New Jersey, United States · 75 investments in the past 12 months

SOSV is a global, deep tech venture capital firm that operates the HAX and IndieBio startup development programs focused on human and planetary health. SOSV invests $500,000 in startups at their inception as they onboard either HAX or IndieBio for a 4-6 month period designed to accelerate the raise of their next institutional round. SOSV joins thelater rounds of HAX and IndieBio graduates. HAX, based in a 35,000 sq ft facility in Newark, NJ, is equipped with machine tools, 3D printers, chemical, electrical and mechanical engineering labs, as well as on-staff engineering and design experts. SOSV's IndieBio has locations in NYC and San Francisco, both of which offer extensive services and facilities to founders including on-site BSL-2 labs, well equipped lab benches and hoods, and advanced lab equipment, such as chromatography equipment.

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Investment focus

  • Biotechnology, Health Care, Software
  • Seed, Convertible Note, Pre-Seed
  • United States, India, United Kingdom

Portfolio highlights

  • MixRift — MIXRIFT - game developers specialized in Mixed Reality
  • unspun — From 3D scan to perfect fitting custom jeans. unspun makes each pair of jeans unique to your actual body and design. On a mission to reduce global carbon emissions by 1%. As seen in Fast Company's World Changing Ideas, Time's Best Inventions, and PopSci's Best of What's New. Welcome to the future of apparel.
  • Mesa Quantum — Unlock the potential of chip-scale quantum sensing for enhanced Position, Navigation, And Timing capabilities. Explore Mesa Quantum's practical solutions.
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ARCH Venture Partners
VC Fund · Chicago, Illinois, United States

ARCH Venture Partners provides seed / early stage venture capital for technology firms in information technology, life sciences, and physical sciences

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Investment focus

  • Biotechnology, Health Care, Therapeutics
  • Series A, Series B, Series C
  • United States, China, United Kingdom

Portfolio highlights

  • SciNeuro — Courage Drives Change - We follow the science to deliver therapeutic solutions for CNS diseases
  • Be Biopharma — Be Bio is developing a proprietary class of engineered B cells as medicines that unleash the potential of cell therapies in applications beyond cytotoxicity.
  • Parabilis Medicines — Parabilis Medicines is a biopharmaceutical company in the clinical stage that focuses on developing exceptional medications targeting challenging protein structures previously deemed undruggable. Utilizing more than ten years of exclusive data, innovative laboratory techniques, and algorithms based on AI and physics, the company has introduced anovel category of stabilized, cell-penetrating alpha-helical peptides known as Helicons™. These peptides can modulate intracellular proteins that traditional drug modalities cannot reach.
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Alexandria Venture Investments
VC Fund · Pasadena, California, United States

Alexandria Venture Investments is a venture capital firm that develops work in real estate technology, and healthcare sectors. The company's strategic venture capital platform is Alexandria Venture Investments. Since its inception in 1996, the company has invested in disruptive life science, agrifood tech, and technology companies that aredeveloping transformative new modalities and platforms to meaningfully improve human health.

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Investment focus

  • Biotechnology, Health Care, Therapeutics
  • Series A, Series B, Series C
  • United States, Canada, France

Portfolio highlights

  • Tr1x — Tr1x develops cellular therapies intended for the treatment of autoimmune disorders.
  • Proxima — Proxima Bio develops programmable medicines that modulate protein interactions to address disease processes. It focuses on creating proximity-modulating therapeutics that direct protein interactions for potential use in conditions such as autoimmune disorders and cancer, expanding the range of targets that traditional drugs cannot easily reach.Proxima Bio combines structural biology, data generation, and machine learning to identify actionable protein-protein interfaces and support the discovery of new therapeutic modalities. The company works with pharmaceutical partners to apply its platform in research collaborations and advance drug discovery pipelines. Proxima Bio’s platform integrates multiple technologies to support the design and discovery of novel proximity-based treatment approaches.
  • NILO Therapeutics — A neuronal circuit regulates the immune system. We're targeting it to treat autoimmune and inflammatory diseases.
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OrbiMed
VC Fund · New York, New York, United States

Leading Global Healthcare Platform with Deep Proprietary Resources and Global Industry Coverage.

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Investment focus

  • Biotechnology, Health Care, Medical
  • Series B, Series A, Series C
  • United States, China, Israel

Portfolio highlights

  • Windward Bio — Windward Bio is a clinical-stage, drug development company committed to improving outcomes for people living with advanced immunological diseases.
  • Microtide Biotechnology — Microtide Biotechnology is an innovative company specializing in the field of in vivo cell therapy. The company is dedicated to advancing next-generation biomedical technologies that harness the body’s own cellular mechanisms for disease treatment, focusing on developing safe, effective, and precise therapeutic solutions to improve patient outcomesand redefine the future of regenerative medicine.
  • Sparrow Pharmaceuticals — Sparrow Pharmaceuticals is an emerging clinical-stage biopharmaceutical company developing novel, targeted therapies for disorders of corticosteroid excess.
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Atlas Venture
VC Fund · Cambridge, Massachusetts, United States

Atlas Venture is an early-stage venture capital firm that creates and invests in biotech startup companies led by promising entrepreneurs focusing on life sciences innovation. Its seed-led venture creation strategy rigorously selects and focuses investment on compelling opportunities to build scalable businesses and realize value.

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Investment focus

  • Biotechnology, Health Care, Therapeutics
  • Series A, Series B, Series C
  • United States, United Kingdom, Canada

Portfolio highlights

  • Disc Medicine — Committed to turning scientific discoveries into effective medicines that will disrupt the current standard of care, alleviate suffering, and have a meaningful impact on the lives of patients and their families.
  • Accent Therapeutics — Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of epitranscriptomics. This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth anddifferentiation. By targeting cancer-linked RNA-modifying proteins (RMPs) with precision therapies, they aim to translate extraordinary science into life-changing therapies for patients.
  • Caldera Therapeutics — Caldera Therapeutics is a biotech company developing bispecific antibodies like CLD-423 for IBD and inflammatory diseases. Discover innovative autoimmune treatments today.
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New Enterprise Associates
VC Fund · Menlo Park, California, United States

Foundational partners to ambitious founders at every stage of company-building.

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Investment focus

  • Software, Health Care, Biotechnology
  • Series A, Series B, Series C
  • United States, India, United Kingdom

Portfolio highlights

  • Moximed — Moximed Inc. is dedicated to improving the standard of care for patients with osteoarthritis, and is investigating therapies to treat a number of affected joints. The lead product, the KineSpring® Knee Implant System, is designed for patients with knee osteoarthritis.
  • Gossamer Bio — Gossamer Bio is a San Diego-based company focused on the discovery and development of novel and differentiated therapeutic products, to address high unmet needs amongst various targeted patient populations. Founded by the former Receptos executive team, Gossamer Bio’s strategy will be to leverage an asset-rich in-licensing environment, with a focuson areas of high unmet need, utilizing a team with a strong track record of execution in immunology, inflammation, fibrosis and oncology.
  • Sagimet Biosciences — Sagimet Biosciences better reflects our expertise in fatty acid metabolism and current focus on developing ground-breaking therapeutics to treat the liver disease NASH.
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Versant Ventures
VC Fund · Menlo Park, California, United States

Versant partners with exceptional entrepreneurs to build and fund breakthrough biotechnology companies around the globe.

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Investment focus

  • Biotechnology, Health Care, Medical
  • Series A, Series B, Series C
  • United States, Switzerland, Canada

Portfolio highlights

  • Achaogen — Achaogen is a clinical stage biopharmaceutical company focused on the discovery and development of broad-spectrum antibiotics to treat multi-drug resistant bacterial infections. The company's most advanced drug candidate, ACHN-490, has demonstrated a positive safety and dosing profile in Phase 1 clinical testing and displayed broad spectrumefficacy in preclinical studies against systemic infections caused by multi-drug resistant (MDR) Gram-negative bacteria (e.g., E. coli, K. pneumoniae, and P. aeruginosa) and MRSA. In addition, the company is pursuing preclinical programs in several other areas of interest to combat the global emergence of bacterial resistance.
  • Standard BioTools — Standard BioTools delivers leading genomic and proteomic solutions. Discover CyTOF, Hyperion and Biomark technologies for deep biological insights.
  • Rennovia — Get full access to this domain. Easy, seamless transactions. Zero percent financing available.
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Polaris Partners
VC Fund · Boston, Massachusetts, United States

Polaris Partners invests in healthcare and biotechnology companies. Their healthcare portfolio companies' care delivery models include digital health, consumer-centric businesses, patient-provider solutions, data science, and analytics. Their life sciences and biotechnology portfolio companies focus on molecules and platforms, therapeutics,and genomics.

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Investment focus

  • Health Care, Biotechnology, Medical
  • Series B, Series A, Series C
  • United States, Ireland, Singapore

Portfolio highlights

  • Thirty Madison — Thirty Madison is a human-first healthcare company, powering access to affordable specialized healthcare through brands like Keeps and Cove.
  • Sonrai Security — Secure cloud and enterprise privileged access with IAM solutions and identity security tools that protect users and data while helping teams deploy faster. Request a demo today.
  • Primmune Therapeutics — Primmune Therapeutics is developing small molecule, orally-administered toll-like receptor 7 (TLR7) agonists to attack tumors and potentiate adaptive cancer immunotherapies, such as checkpoint inhibitors, to improve overall response rates and treatment durability.
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Innova Memphis
VC Fund · Memphis, Tennessee, United States

Founded in 2007 by the Memphis Bioworks Foundation, Innova is a pre-seed, seed and early-stage investor focused on starting and funding high-growth companies in the Biosciences, Technology and AgBio fields across the state of Tennessee. Innova links capital with great ideas to create groundbreaking products and services.At Innova we invest instart-up companies, help them grow, and then assist them in linking with established corporations for licensing, buy-outs or further investments. We provide the synergy of experienced management, market expertise and venture capital to accelerate the development of new products and services into viable business units that can stand on their own and then take their place with a mature market leader, if desired.Whether an innovation is still on the drawing board or stalled in the market place the Innova staff has the expertise, skills, and experience to envision and create a functioning business unit that is prepared to thrive in the market place. Technical know-how, market-proven staffing, and "just-right" funding assure the greatest chance possible for success.

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Investment focus

  • Health Care, Medical, Medical Device
  • Seed, Pre-Seed, Funding Round
  • United States, Argentina, United Kingdom

Portfolio highlights

  • HerdDogg — HerdDogg is passionate about livestock. Its innovative data platform sits at the intersection of agtech, the internet of things, and global food security. Our patented DoggTags and DoggBone, together with our Animal Traceability Platform, help producers make more money from every animal they raise. The HerdDogg system enables animal tracking,welfare monitoring and traceability in an easy-to-use application. For more information, visit herddogg.com.
  • Rescue Forensics — Customer service is our #1 priority. Get a premium domain for your website today. Financing available.
  • Soiltech Wireless — Soiltech Wireless is a developer of ag-tech solutions to design electronic devices for agricultural professionals. Its product provides real-time data to drive efficiency and optimize quality. It also provides actionable data without installation hassles and creates scalable monitoring solutions for farmers.The company was founded in 2019 and isheadquartered in Rupert, Idaho.
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Khosla Ventures
VC Fund · Menlo Park, California, United States

Khosla Ventures is a venture capital firm that invests in early- to late-stage companies across sectors like AI, healthcare, sustainability, and consumer technology. It manages multiple funds, focusing on startups with innovative technologies or business models. The firm primarily targets sectors like AI, climate tech, digital health, and medtech,offering strategic support to help build long-lasting companies.

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Investment focus

  • Software, Artificial Intelligence, Health Care
  • Series A, Series B, Seed
  • United States, India, United Kingdom

Portfolio highlights

  • Liberate Bio — Liberate Bio focuses on advancing non-viral delivery technologies for nucleic acid cargoes such as ASOs and siRNAs. The company aims to develop new vehicles to deliver oligonucleotide cargos, addressing genetic disorders. With a team of 50 employees, Liberate Bio operates within the biotechnology industry, working on innovative solutions fortargeted delivery systems.
  • Li Industries — At Li Industries, we are building battery recycling technologies that enable greater automation, competitiveness, and sustainability.
  • LanzaTech — LanzaTech is turning our global carbon crisis into a feedstock opportunity with the potential to displace 30% of crude oil use today and reduce global CO2 emissions by 10%. By recycling carbon from industrial off-gases; syngas generated from any biomass resource (e.g. municipal solid waste (MSW), organic industrial waste, agricultural waste); andreformed biogas, LanzaTech can reduce emissions and make new products for a circular carbon economy.LanzaTech’s carbon recycling technology is like retrofitting a brewery onto an emission source like a steel mill or a landfill site, but instead of using sugars and yeast to make beer, pollution is converted by bacteria to fuels and chemicals! Imagine a day when your plane is powered by recycled GHG emissions, when your yoga pants started life as pollution from a steel mill. This future is possible using LanzaTech technology.
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5AM Ventures
VC Fund · Menlo Park, California, United States

5AM Ventures is a venture capital firm that offers seed- and early-stage investments to its clients. The company’s client portfolio consists of firms in the biopharmaceutical, life sciences, medical technology, and research instrument industries. 5AM Ventures was founded in 2002 by John Diekman and Andrew Schwab and is based in California.

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Investment focus

  • Biotechnology, Health Care, Therapeutics
  • Series A, Series B, Series C
  • United States, Switzerland, United Kingdom

Portfolio highlights

  • Ensoma — Ensoma is expanding the reach of the curative power of genomic medicine by pioneering a next-generation in vivo approach using its Engenious™ vectors. Ensoma’s vectors are designed to deliver a diverse range of gene modification technologies without the need for stem cell collection or prior myeloablative conditioning (e.g., chemotherapy). As aresult, Ensoma’s therapies can be delivered as a single injection in a diverse range of settings, including outpatient and settings where access to sophisticated healthcare systems may be limited.
  • Mendra — Mendra is a biopharmaceutical company that uses AI to accelerate clinical development and commercialization of breakthrough medicines for diseases with high unmet need.
  • Kinaset Therapeutics — Kinaset Therapeutics is a therapeutics company that focuses on the advancement of novel drugs in areas of unmet medical needs. The company was founded in 2020 and is headquartered in Medfield, Massachusetts.
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Third Rock Ventures
VC Fund · Boston, Massachusetts, United States

Third Rock Ventures invests in transformational life science companies that show high growth potential and are well-positioned to make a difference in the marketplace. Third Rock Ventures believes in the companies we start and makes significant initial investments, which are frequently supplemented by strategic collaborations, to help our firmsprogress in life-changing medicines, technologies, and diagnostics.

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Investment focus

  • Biotechnology, Health Care, Therapeutics
  • Series A, Series B, Series C
  • United States

Portfolio highlights

  • Trace Neuroscience — Trace Neuroscience is a biopharmaceutical company that aims to extend the promise of genetic medicine to patients with neurodegenerative illnesses.
  • Jounce Therapeutics — Concentra is a biosciences company.
  • Seaport Therapeutics — Seaport Therapeutics operates as a clinical stage biopharmaceutical company.
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MPM Capital
VC Fund · Cambridge, Massachusetts, United States

Powering Breakthroughs in Life Sciences

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Investment focus

  • Biotechnology, Health Care, Pharmaceutical
  • Series A, Series B, Series C
  • United States, Canada, United Kingdom

Portfolio highlights

  • Umoja Biopharma — Pioneering immunotherapy by reprogramming T cells in vivo to target cancer cells.
  • Syndax Pharmaceuticals — Syndax Pharmaceuticals is a clinical-stage pharmaceutical company that focuses on an HDAC inhibitor for solid tumors and hematological tumors. It offers therapies to treat solid tumors and lung, breast, and hematological cancer. The company is developing axatilimab, a monoclonal antibody that blocks the colony-stimulating factor 1 (CSF-1) receptor,in development for chronic Graft versus Host Disease, and entinostat, a class I HDAC inhibitor.Syndax Pharmaceuticals pipeline includes and SNDX-5613, a highly selective inhibitor of the Menin–MLL binding interaction, in development for the treatment of patients with MLLr and NPM1 acute leukemias.
  • Portola Pharmaceuticals — As Alexion, AstraZeneca Rare Disease, we are delivering life-changing therapies to people living with rare diseases.
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RA Capital Management
VC Fund · Boston, Massachusetts, United States

RA Capital Management is an investment advisor based in Boston specializing in the life-sciences and drug development sectors. The company's team has been investing since 2002 and is comprised of professionals with training in biology, chemistry, and medicine and also has industry and business development experience at the executive and boardlevels. The company invests in companies with promising technologies and products.

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Investment focus

  • Biotechnology, Health Care, Therapeutics
  • Series B, Series C, Post-IPO Equity
  • United States, United Kingdom, Canada

Portfolio highlights

  • Capacity Bio — Capacity Bio is a private, biotech company developing a first-in-class mitophagy therapeutic platform, along with the most advanced analytical toolkit to characterize mitochondria.
  • Windward Bio — Windward Bio is a clinical-stage, drug development company committed to improving outcomes for people living with advanced immunological diseases.
  • Avalanche Energy — Avalanche Energy operates as a fusion energy start-up.
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F-Prime
VC Fund · Cambridge, Massachusetts, United States

F-Prime Capital is a global venture capital firm investing in healthcare and technology, with a heritage that spans four decades.

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Investment focus

  • Health Care, Biotechnology, Medical
  • Series A, Series B, Series C
  • United States, United Kingdom, China

Portfolio highlights

  • Immutrin — Immutrin is a biotechnology company developing next‑generation antibody therapies designed to clear systemic amyloid deposits and reverse amyloidosis, this company lead asset targets ATTR cardiomyopathy, a severe and progressive form of amyloidosis, and its antibody represents a potential best‑in‑class treatment engineered to selectively andspecifically remove established amyloid fibrils.
  • Truthsystems — Truth Systems offers real-time compliance agents that prevent human error by embedding behavioral guardrails into AI interactions.
  • Bluebird Kids Health — Bluebird Kids Health is launching a proprietary technology platform to proactively manage and coordinate treatment, with AI enhancing and simplifying the experience for its clinical team.
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BioAdvance
VC Fund · Philadelphia, Pennsylvania, United States

BioAdvance actively invests venture capital in therapies, medical devices, research tools, diagnostics and health IT in the Mid-Atlantic region.

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Investment focus

  • Biotechnology, Health Care, Medical
  • Seed, Funding Round, Series A
  • United States, Canada

Portfolio highlights

  • KayoThera — KayoThera is a biotechnology company developing therapeutics used to cure late-stage and metastatic cancers. Its programs work on inhibiting a key enzyme that is responsible for protecting the cancer cells and depleting regulatory T-cells that intends to cure hitherto incurable cancers and give hope to patients. The company's mission is todevelop the first-in-class immuno- and targeted therapies to drive cures in advanced cancersKayoThera was founded in 2019 and is headquartered in Princeton, New Jersey.
  • Tolerance Bio — Tolerance Bio will increase health span by preserving and restoring the function of the thymus, the master regulator of immune tolerance. Immune-mediated diseases represent a significant unmet medical challenge: cancer, autoimmunity, transplant rejection, infections, immune deficiencies, and allergi
  • Vittoria Biotherapeutics — Vittoria Biotherapeutics develops gene-edited cell therapies.  they provide next-generation, paradigm-shifting T-cell therapeutics that address unmet medical needs. Senza5 Technology from viTToria improves the efficacy, safety, and utility of cell-based treatments in preclinical settings.
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Canaan Partners
VC Fund · Menlo Park, California, United States

Canaan is an early stage venture capital firm that invests in entrepreneurs with visionary ideas. With $5B under management, a diversified fund and over 190 exits to date, Canaan has invested in some of the world's leading technology and healthcare companies over the past 30 years. Canaan’s focus areas include fintech, enterprise/cloud,marketplaces, frontier tech, biopharma, digital health, and medtech.

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Investment focus

  • Software, Biotechnology, Health Care
  • Series A, Series B, Series C
  • United States, United Kingdom, Israel

Portfolio highlights

  • CarTrade — CarTrade - Buy and Sell Used Cars in India at right price. Find New Cars, car prices, upcoming cars and images. Read latest auto news, reviews and car comparisons.
  • Matrimony.com — Revolutionizing the Indian matrimonial industry with world class matchmaking and wedding planning services. Your search for the perfect match ends here!
  • Journey Live — Journey is shifting the way modern companies prioritize mental health. Our proactive, inclusive tools engage every employee, every day.
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Andreessen Horowitz
VC Fund · Menlo Park, California, United States

Andreessen Horowitz (a16z) is a venture capital firm in Silicon Valley, California, investing in bold founders, innovators, and entrepreneurs building the future through technology.

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Investment focus

  • Software, Information Technology, Artificial Intelligence
  • Series A, Seed, Series B
  • United States, United Kingdom, Brazil

Portfolio highlights

  • Revolut — Join 40+ million customers globally using Revolut to send money to 160+ countries, hold up-to 36 currencies in app, spend in 150+ currencies, and manage their money.
  • Platfora — Platfora’s mission is to empower customers to transform their businesses into fact-based enterprises. Platfora's Big Data Analytics Platform masks the complexity of Hadoop, making it easy for customers to understand all the facts in their business across events, actions, behaviors and time.
  • Lead — Lead Bank is a community-minded, independent commercial bank with a national client base recognized for its imaginative approach to community banking.
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Alumni Ventures
VC Fund · Manchester, New Hampshire, United States

Access curated startup investment opportunities and diversified venture capital exposure designed for accredited investors.

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Investment focus

  • Software, Artificial Intelligence, Information Technology
  • Seed, Series A, Series B
  • United States, United Kingdom, Canada

Portfolio highlights

  • LOLIWARE — LOLIWARE is rewriting the story of destructive packaging. By harnessing the power of seaweed to replace plastic at scale, LOLIWARE is tapping into its potential to regenerate our ocean and decarbonize our planet.
  • Kolors — Kolors is a technological platform that focuses on providing intelligent intercity mobility of bus transportation in the region.
  • ARRIS — Using next-gen advanced manufacturing technologies, ARRIS Composites produces smarter, lighter, stronger, and more sustainable products at scale.
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The Column Group
VC Fund · San Francisco, California, United States

The Column Group (TCG) is a venture ecosystem dedicated to fueling scientific innovation in the life sciences industry.

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Investment focus

  • Biotechnology, Health Care, Therapeutics
  • Series A, Series B, Series C
  • United States

Portfolio highlights

  • Atavistik Bio — Atavistik Bio is harnessing the power of protein-metabolite interactions to add a new lens to drug discovery.
  • Gritstone bio — Gritstone Oncology is a clinical-stage biotech company developing tumor-specific cancer immunotherapies to fight multiple cancer types. Its approach seeks to generate a therapeutic immune response by leveraging insights into the immune system’s ability to recognize and destroy tumor cells by targeting tumor-specific neoantigens. GritstoneOncology is headquartered in Emeryville, California, with key functions located in Cambridge, Massachusetts, and Pleasanton, California. It was founded in August 2015 and is listed on the Nasdaq Global Select Market under the ticker symbol GRTS.
  • Carmot Therapeutics — Breakthrough science. One moment, one day, one person at a time.
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Novartis Venture Fund
VC Fund · Basel, Basel-Stadt, Switzerland

Learn about the approach the Novartis Venture Fund takes to investing in innovative life science companies developing biotechnology and biopharmaceutical therapeutics that address unmet patient needs.

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Investment focus

  • Biotechnology, Health Care, Therapeutics
  • Series A, Series B, Series C
  • United States, Switzerland, United Kingdom

Portfolio highlights

  • Granite Bio — Targeting fundamentals of Inflammation, Autoimmunity and Fibrosis. Granite Bio develops first-in-class therapeutic antibodies depleting pathogenic cells with the potential to transform inflammatory and fibrotic diseases.
  • NRG Therapeutics — energizing drug discovery in neurodegenerative diseases.
  • Atalanta Therapeutics — Atalanta was created to address the urgent global need for interventions to treat neurodegenerative diseases.
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KdT Ventures
VC Fund · Austin, Texas, United States

KdT Ventures is the standard for early-stage frontier science investing.

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Investment focus

  • Biotechnology, Health Care, Medical
  • Seed, Series A, Series B
  • United States, Israel, Germany

Portfolio highlights

  • Zag Bio — Zag Bio is harnessing the immune system in a whole new way by targeting the thymus to change treatment possibilities for millions of patients with autoimmune diseases.
  • PHNX Materials — At PHNX Materials, we transform unusable landfilled coal ash into sustainable products. Join our journey as we leverage cutting-edge chemistry to create a cleaner planet by producing a green SCM, titanium, aluminum and rare-earth elements.
  • Faeth Therapeutics — Home | Faeth
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Lux Capital
VC Fund · New York, New York, United States

Lux Capital manages over $5 billion in assets focused on founding, seed, early-stage, and growth investments at the intersection of technology and the sciences. Lux takes an active role in helping entrepreneurs build successful businesses in high-growth sectors. Its investment team has built over 20 companies from scratch. Lux's investmentstrategy ensures portfolio companies are better connected, have a deeper insight, and command industry leadership faster than their competitors.

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Investment focus

  • Software, Artificial Intelligence, Health Care
  • Series A, Seed, Series B
  • United States, United Kingdom, Canada

Portfolio highlights

  • Clarifai — Clarifai is the leading Machine Learning, Computer Vision, NLP Platform. Label, train, deploy models on one AI platform for developers & data scientists.
  • Primer — Primer makes powerful mission-ready AI software designed to work in your environment, on your data. We help national security teams sift through massive unstructured data sets to find the needle in the haystack, understand and visualize their data, and act collaboratively. Our mission is to empower decisions that can be defended, and acted upon confidently.
  • Atavistik Bio — Atavistik Bio is harnessing the power of protein-metabolite interactions to add a new lens to drug discovery.
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DCVC
VC Fund · San Francisco, California, United States

We are deep tech venture capital.

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Investment focus

  • Software, Artificial Intelligence, Machine Learning
  • Seed, Series A, Series B
  • United States, Canada, United Kingdom

Portfolio highlights

  • Halter — Halter creates GPS enabled, solar powered collars for cows. The collar hardware allows farmers to use simple tablet app software to remotely set geographic boundaries for cattle, virtual fences. Farmers use Halter's system to avoid physically herding cows, maximizing farmer time and productivity.
  • evonetix — evonetix is a new spin-out company that is currently incubating in the centre of the world-renowned Cambridge cluster of high-tech and life science organisations. We are seeking to develop and commercialise a new approach to the synthesis of DNA to facilitate the fast-emerging and exciting field of synthetic biology. By employing novel techniqueswe are able to advance DNA synthesis to levels never before seen. Our engineering team has decades of experience developing high integrity automated systems. Our high calibre team brings together expertise from across the scientific and engineering disciplines.
  • Fourth Power — Fourth Power makes renewable energy an on-demand energy source through utility-scale, thermal battery technology. With the ability to provide flexible-duration energy storage, we can start small and grow with the grid to save consumers money and ensure a clean energy future.
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Fifty Years
VC Fund · San Francisco, California, United States

WE BACK HEROES using technology to solve the world's biggest problems

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Investment focus

  • Biotechnology, Health Care, Medical
  • Seed, Series A, Series B
  • United States, Germany, Canada

Portfolio highlights

  • Farcast — Unlocking satellite internet capacity through user terminal innovation
  • Deepcell — Deepcell uses AI to isolate and capture cells based on morphological features for multiple research and translational applications.
  • Electroflow Technologies — Electroflow Technologies Inc.: Start-up working on direct Lithium extraction and refinement from low concentration brines using renewable electricity and minimal chemicals.
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Connecticut Innovations
VC Fund · Rocky Hill, Connecticut, United States

At Connecticut Innovations, we see venture capital the way you see your business. Like no one else. We invest in innovative biotech, IT, and other industries.

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Investment focus

  • Health Care, Biotechnology, Software
  • Seed, Series A, Funding Round
  • United States, Israel, Canada

Portfolio highlights

  • Device42 — Device42 sets the standard as the most comprehensive, agentless discovery and dependency mapping solution, spanning from legacy mainframes to cloud containers.
  • Mobile Sense — The traditional diagnostic market is being transformed by advances in high performance wearables. This seismic shift led by consumer products which are uncovering new patients who previously went undetected, but still require a detailed diagnosis. Mobile Sense™ is building foundational technology that enables this transformation throughoff-the-chest wearables for long term management of cardiac arrhythmias. Developed over 7 years with $4.2M in grant funding and $1.3M in seed funding, Mobile Sense™ has a platform for differentiated wearables. Our embedded algorithms coupled with non-adhesive, wireless & waterproof sensors provides high fidelity continuous ECG and PPG recordings. The automatic monitoring provides 24/7, 365 days/yr continuous detection and classification of dangerous heart arrhythmias.
  • NovaTract Surgical — NovaTract Surgical is a development stage company, intends to develop medical devices to address the rapidly growing field of Single Incision Laparoscopic Surgery (SILS) and Natural Orifice Transluminal Endoscopic Surgery (NOTES). The company was incorporated in 2010 and is based in Guilford, Connecticut.
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Google Ventures
VC Fund · Mountain View, California, United States

GV supports innovative founders moving the world forward.

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Investment focus

  • Software, Health Care, Biotechnology
  • Series A, Series B, Seed
  • United States, United Kingdom, Switzerland

Portfolio highlights

  • Vercel — Vercel gives developers the frameworks, workflows, and infrastructure to build a faster, more personalized web.
  • Iterative Health — Iterative Health is a healthcare technology and services company that focuses on accelerating clinical research to improve patient outcomes through innovative approaches. The company transforms gastrointestinal (GI) care by utilizing AI-driven clinical trials and diagnostics, significantly enhancing access to vital treatments.
  • Parabilis Medicines — Parabilis Medicines is a biopharmaceutical company in the clinical stage that focuses on developing exceptional medications targeting challenging protein structures previously deemed undruggable. Utilizing more than ten years of exclusive data, innovative laboratory techniques, and algorithms based on AI and physics, the company has introduced anovel category of stabilized, cell-penetrating alpha-helical peptides known as Helicons™. These peptides can modulate intracellular proteins that traditional drug modalities cannot reach.
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Mission BioCapital
VC Fund · Cambridge, Massachusetts, United States

Mission BioCapital is a life science venture capital firm that invests in early-stage companies. The company leadership team has a long history together, investing in and launching dozens of early-stage life science companies. They are located in regions with a rich concentration of research, discovery, and venture capital investment, and they areknown by leaders of portfolio companies for the expertise and deep support they provide.

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Investment focus

  • Biotechnology, Health Care, Therapeutics
  • Series A, Series B, Funding Round
  • United States, France, Germany

Portfolio highlights

  • EpiBiologics — EpiBiologics develops first-in-class antibody based targeted therapies against membrane and extracellular proteins that drive underlying disease biology.
  • Bullseye Biosciences — Bullseye Biosciences is a therapeutics discovery company revolutionizing drug development through robotics and evolution. Our platform operationalizes cutting-edge directed evolution technology by incorporating automation and Next Generation Sequencing. By targeting challenging drivers of human dise
  • Sensorium Therapeutics — Clinical-stage biotech discovering novel CNS therapies from natural compounds validated by millennia of human use. Anxiety, epilepsy, Alzheimer's.
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Hatteras Venture Partners
VC Fund · Durham, North Carolina, United States

Hatteras Venture Partners is a venture capital firm based in Research Triangle Park, NC, with a focus on biopharmaceuticals, medical devices, diagnostics, and related opportunities in human medicine. Founded in 2000, the firm consists of an experienced team with a broad and complementary skill set that is particularly relevant to buildingsuccessful new biomedical companies. The Hatteras Venture Partners team brings operational experience, a successful track record, and a proven ability to enhance the value of the companies in which it invests. With three funds, the firm has more than $120 million under management.

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Investment focus

  • Biotechnology, Health Care, Medical
  • Series A, Series B, Series C
  • United States, Canada

Portfolio highlights

  • iRiva Medical — iRiva Medical is developing novel neuromodulation therapies to address unmet therapeutic requirements in large patient populations.
  • Sensorium Therapeutics — Clinical-stage biotech discovering novel CNS therapies from natural compounds validated by millennia of human use. Anxiety, epilepsy, Alzheimer's.
  • TetraLogic Pharmaceuticals — TetraLogic Pharmaceuticals is a privately held biopharmaceutical company that discovers and develops small molecule drugs that modulate programmed cell death pathways to treat debilitating diseases and conditions. The company's Smac Mimetics neutralize critical blocks in the apoptosis pathway to selectively destroy cancer cells. ItsNecrostatin drugs block critical steps in the process leading to necrosis, enabling cell survival in a wide range of diseases and injuries where necrosis is a critical component of pathology.
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Dolby Family Ventures
VC Fund · San Francisco, California, United States

Investing in early-stage companies solving the biggest science and engineering challenges since 2014.

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Investment focus

  • Biotechnology, Health Care, Therapeutics
  • Series A, Seed, Series B
  • United States, Austria, Switzerland

Portfolio highlights

  • Therini Bio — Therini Bio is developing novel therapeutics based insights into the role of fibrin in driving chronic innate immune activation.
  • Lightform — Lightform LFC Kit and LF2+ AR projector enable you to create light and sound experiences with sound-reactive projection mapping. Lightform brings projection mapping in reach for visual artists, designers, and other creatives.
  • TripleBlind — TripleBlind unlocks the estimated 105 petabytes of data stored by enterprises today that are inaccessible and not commercialized due to privacy concerns, operational complexity and regulation. The company’s patented breakthroughs in advanced mathematics enable organizations to privately share larger and more diverse data sets. Many high-valueapplications apply, such as innovating enhanced algorithms for medical diagnoses and improving anti-fraud initiatives for financial services. TripleBlind is the only technology that enables enterprises to rapidly commercialize data while maintaining compute performance; enabling all types of analysis on all data types, such as PII, PHI, genomic data, images, and confidential financial records. At the same time, the solution automatically enforces all international and regional data privacy standards including HIPAA, GDPR, PDPA and CCPA.TripleBlind is superior to existing solutions such as homomorphic encryption (slows compute performance), secure enclaves (siloes data), tokenization/masking/hashing and differential privacy (reduces accuracy), synthetic data (not real data), federated learning (limited use for algorithms), confidential computing (requires data centralization) and blockchain (not interoperable). Innovators such as Accenture, the Mayo Clinic and Snowflake trust TripleBlind to protect sensitive data. Please contact us for an overview, live demo or a one-hour, hands-on workshop.
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Frazier Healthcare Partners
VC Fund · Seattle, Washington, United States

With its purpose-driven culture and deep industry expertise, Frazier Healthcare is the preferred partner to profitable healthcare companies.

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Investment focus

  • Biotechnology, Health Care, Therapeutics
  • Series B, Series A, Post-IPO Equity
  • United States, Canada, Ireland

Portfolio highlights

  • Passage Bio — Passage Bio, a genetic medicines company, is changing the future of CNS disorders and transforming the lives of patients and their families.
  • Zeltiq Aesthetics — Learn about the CoolSculpting cryolipolysis procedure.
  • Knipper Health — Knipper Health supports Pharma & Life Science Companies by Managing & Executing all Pharmaceutical Sampling & 3PL Services. Learn More!Knipper Health supports Pharma & Life Science Companies by Managing & Executing all Pharmaceutical Sampling & 3PL Services. Learn More!
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Pfizer Venture Investments
VC Fund · New York, New York, United States

Pfizer Venture Investments is a corporate venture capital firm that invests in areas of current or future strategic interest to Pfizer. It aims to remain at the forefront of life science advances. It identifies and invests in emerging companies that are developing transformative medicines and technologies that have the potential to enhance Pfizer’spipeline and shape the future of its industry.

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Investment focus

  • Biotechnology, Health Care, Therapeutics
  • Series B, Series A, Series C
  • United States, United Kingdom, Switzerland

Portfolio highlights

  • Ablexis — Ablexis, LLC, a biotechnology company dedicated to developing an innovative, next-generation platform for antibody drug discovery, was founded in December 2009, based on technology principles established by its subsidiary, Aliva Biopharmaceuticals, Inc.
  • Artios Pharma — Artios is a leading independent DDR Company with a strong pipeline of novel cancer therapies in development with first-in-class & best-in-class potential.
  • Mirna Therapeutics — Mirna Therapeutics, Inc. (Mirna) is a discovery-stage biopharmaceutical research and development company focused on miRNA-directed human oncology therapies. Featuring world-class research capabilities, a strong understanding of miRNA and cancer biology, and an expansive IP portfolio, Mirna Therapeutics is well-positioned to capitalize on theemerging field of miRNA-based therapeutics.
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Sofinnova Investments
VC Fund · Menlo Park, California, United States

Sofinnova deploys human and financial capital to turn dreams into drugs. We are a clinical-stage biopharmaceutical venture capital firm with approximately $2B in assets under management and committed capital.

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Investment focus

  • Biotechnology, Health Care, Pharmaceutical
  • Series B, Series A, Series C
  • United States, France, Switzerland

Portfolio highlights

  • Cebix — Cebix is focused on the development of chronic replacement therapy based on human proinsulin C-peptide for the treatment of type 1 diabetic neuropathy. The role of C-peptide will also be explored in type 1 diabetic nephropathy and retinopathy.
  • Trius Therapeutics — Trius Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of innovative antibiotics for life-threatening infections.We have successfully completed two Phase 3 clinical trials for Tedizolid Phosphate (TR-701), formerly torezolid phosphate, in ABSSSI. Tedizolid is an IV and orally administeredsecond generation oxazolidinone, for the treatment of serious gram-positive bacterial infections, including those caused by methicillin-resistant Staphylococcus aureus (MRSA). With the continuous increase in bacterial resistance to currently marketed drugs, serious infections are becoming more difficult, if not impossible to treat, and this has led to a clear need for novel therapeutics to treat multi-drug resistant bacterial infections.Trius is headquartered in San Diego, California. We have built a strong management team with significant development and regulatory experience. Our senior management team consists of nine individuals who collectively have been involved in the development and approval of a significant number of anti-infective drugs.
  • Invitae — Invitae and Labcorp together offer advanced genetic testing that can be easily integrated into medical practices. Improve patient care with meaningful insights based on DNA.
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Life Science Angels
VC Fund · Sunnyvale, California, United States

Life Science Angels, Inc. (LSA) is the premier angel investment group focused solely on healthcare investing, including medical devices, diagnostics, pharmaceuticals, biotechnology, and digital health.

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Investment focus

  • Biotechnology, Health Care, Medical
  • Funding Round, Seed, Series A
  • United States, Israel, The Netherlands

Portfolio highlights

  • Neurava — Neurava has developed wearable diagnostics for epilepsy patients including those at risk of SUDEP. The company specializes in the fields of medical device manufacturing, healthcare, and health diagnostics.
  • Flyte — Flyte promotes cellular healing in pelvic floor muscles for lasting results. Flyte is fast, proven, safe, pelvic floor therapy for bladder control.
  • Trio Pharmaceuticals — Trio Pharmaceuticals is a cancer therapeutics company that develops dual-action drugs for immunogenic tumors. These drugs directly stop tumor growth and selectively stop immunosuppression in the tumor without targeting the current immune checkpoint pathways. The company was founded in 2018 and is headquartered in San Diego, California.
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Northpond Ventures
VC Fund · Bethesda, Maryland, United States

Northpond Ventures is a science-driven venture capital firm headquartered in Bethesda, Maryland. Our mission is to build a better tomorrow. Our investments are focused on life sciences, technology, and affiliated industries.

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Investment focus

  • Biotechnology, Health Care, Life Science
  • Series A, Series B, Series C
  • United States, United Kingdom, Canada

Portfolio highlights

  • Vizgen — Vizgen is a privately held biotech company developing the next generation of spatially resolved, single-cell transcriptomics technology and toolbox. The company's patented MERFISH technology enables massively multiplexed, genome-scale nucleic acid imaging with high accuracy and detection efficiency at subcellular resolution. The highthroughput and resolution and the low cost per cell achieved by the technology will enable a wide range of tissue-scale basic research and development and will be instrumental to efforts to discover and map cell types and states in a range of tissues and organisms.
  • Octave — Octave Bioscience is an early-stage molecular diagnostics company focused on neurodegenerative diseases and conditions. The company was co-founded by Melinda Thomas and William Hagstrom in 2013. Octave Bioscience is headquartered in Menlo Park, California, United States.
  • Elephas — Elephas is a live tumor imaging company developing novel cancer diagnostic solutions to predict treatment outcomes and accelerate drug development.
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Boston Harbor Angels
VC Fund · Boston, Massachusetts, United States

Boston Harbor Angels is a group of proven business leaders interested in investing a portion of their assets in high growth, early stage companies. The group was formed in February 2004 and since then has made a number of investments in companies in medical devices, IT, consumer products, business products, specialty materials, Internet, aviation,etc. They believe they contribute more than money to the companies they fund and welcome the opportunity to work with entrepreneurs open to take advice, yet having the smarts and determination to make the company successful.Their focus is on early stage companies usually looking to raise $250K to $1.5M, where they can fund a portion of the round and syndicate the deal with other angel groups or early stage venture funds. The stage of the company should be close to commercialization, while the company should have a clear and defensible competitive advantage. They are looking for capital efficient businesses, which can reach profitability with less than $5M of equity investment and provide at least 10X return on the investment within 5 years.They do not invest as a fund - each of their members makes his or her individual investment decision but they collaborate in Due Diligence. They have a deep expertise in the life sciences field where they usually take the position of a lead investor, but are open to any opportunities that can make a strong business case. In some cases they prefer to be the follow on investor if they cannot identify a person with strong expertise within their group.The group’s strategy is directed by an executive committee which consists of 8 people elected by the group: Wayne Griffith (chairman), Bill McPhee, Henry Kay, Jay Schwartz (membership director), Steve Andress, Peter Miller, Don Freeman and Mic Williams (president and founder). The group’s day-to-day operations are managed by Boris Batchvarov (managing director).They receive 20-30 business summaries each month, out of which they select 8 companies to make a personal presentation to their screening committee. The screening committee consists of volunteers from the group. The presentations are 10 min long followed by 10 min Q&A. 4 of the companies are invited to present to the whole group, with the idea to get the people interested and decide to perform a Due Diligence with the companies before making an investment.

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Investment focus

  • Biotechnology, Health Care, Medical Device
  • Angel, Seed, Series A
  • United States, Canada, India

Portfolio highlights

  • Zylö Therapeutics — Patented technology that enables, for topicals, sustained release, increased druggability, a Patchless Patch concept, and enhanced targeting of pores and follicles
  • Xeno Biosciences — Xeno Biosciences operates as a biopharmaceutical company pioneering a novel class of therapeutics to address large unmet needs in metabolic diseases. Lead program, XEN-101, is a first-in-class, oral formulation designed to shift the gut microbiome to the weight-loss associated state induced by Roux-en-Y Gastric Bypass (RYGB) surgery.It wasfounded in 2015 and is headquartered in Somerville, Massachusetts.
  • Astrocyte Pharmaceuticals — Astrocyte Pharmaceuticals Inc. is a privately held drug development company dedicated to accelerating the recovery and well-being of brain injury patients. The company is committed to proving the neuroprotective benefits of selective astrocyte activation, and advancing breakthrough therapeutic agents for treating brain injury resulting from stroke,TBI, concussion, and neurodegenerative disorders such as Alzheimer’s disease.
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Novo Holdings
VC Fund · Hellerup, Hovedstaden, Denmark

Novo Holdings is a world-leading life science investor with a focus on creating long-term value.

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Investment focus

  • Biotechnology, Health Care, Medical
  • Series A, Series B, Series C
  • United States, Denmark, United Kingdom

Portfolio highlights

  • Precirix — Developing radio-immunotherapeutic drugs for cancer patients.
  • IVERIC bio — IVERIC bio is a science-driven biopharmaceutical company focused on the discovery and development of novel treatment options for retinal diseases with significant unmet medical needs. The Company is currently developing both therapeutic product candidates for age-related retinal diseases and gene therapy product candidates for orphan inheritedretinal diseases.
  • Windward Bio — Windward Bio is a clinical-stage, drug development company committed to improving outcomes for people living with advanced immunological diseases.
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Civilization Ventures
VC Fund · San Francisco, California, United States

DIGITAL HEALTH / AI DIGITAL HEALTH / AI GENE / CELL THERAPIES NASDAQ: RCKT GENE / CELL THERAPIES NASDAQ: RCKT GENOMICS / DIAGNOSTICS GENOMICS / DIAGNOSTICS SYNTHETIC

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Investment focus

  • Biotechnology, Health Care, Medical
  • Seed, Series A, Series B
  • United States, United Kingdom, Brazil

Portfolio highlights

  • Wyndly — Retrain your allergies through sublingual (under-the-tongue) treatment plans. Virtual appointments. Treatment delivered. Get started after your first consult with a board-certified doctor for $49.99.
  • Trial Library — At Trial Library, we partner with the oncology community to enable the discoverability of clinical trials for anyone, anywhere.
  • Foresight Diagnostics — We develop innovative diagnostics to advance decision-making in oncology drug development and patient care.
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Domain Associates
VC Fund · San Diego, California, United States

INVESTMENT ADVISORS TO THE FIRST VC FUND DEDICATED TO BIOTECH INVESTMENT MANAGER OF 9 SUBSEQUENT BIOTECH VC FUNDS

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Investment focus

  • Biotechnology, Health Care, Medical
  • Series B, Series C, Series A
  • United States, Canada, Estonia

Portfolio highlights

  • Epic Sciences — Epic Sciences develops clinical solutions that accelerate drug development and guided therapy across cancer drug indications. Epic's new AR-V7 CTC liquid biopsy test is the first clinically proven predictive test for metastatic castration-resistant prostate cancer.
  • Antios Therapeutics — This is an example page. It's different from a blog post because it will stay in one place and will show up in your site navigation (in most themes). Most people start with an About page that introduces them to potential site visitors. It might say something like this: Hi there! I'm a bike messenger
  • Fractyl Health — Fractyl Health develops innovative medical device solutions for the treatment of chronic diseases. The growing product pipeline leverages our minimally invasive procedural therapy, Revita DMR (duodenal mucosal resurfacing), which is designed to rejuvenate the lining of the duodenum and improve patient health. They envision a world with bettersolutions to chronic diseases through the use of less invasive, device-based therapies that will lessen the burden on patients, physicians, and payers.Fractyl Health aims to bring curative therapies to the large populations of patients with metabolic disease.
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Omega Funds
VC Fund · Boston, Massachusetts, United States

We aim to invest in exceptional founders and entrepreneurs and impactful products and platforms across multiple therapeutic areas.

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Investment focus

  • Biotechnology, Health Care, Therapeutics
  • Series A, Series B, Series C
  • United States, Switzerland, United Kingdom

Portfolio highlights

  • IFM Therapeutics — IFM Therapeutics is a provider of small molecule that module novel targets in the innate immune system. The company and its academic collaborators combine unparalleled expertise in innate immunity with seasoned drug discovery and development professionals. Its subsidiary IFM Due is focused on the discovery and developing antagonists of thecGAS/STING pathway for the treatment of inflammation, neuroinflammation, autoimmunity and cancer. IFM Discovery, a newly financed incubator entity within the IFM enterprise, is prosecuting a basket of genetically-validated targets as next-generation therapies for inflammation, neuroinflammation, autoimmunity and fibrosis
  • NRG Therapeutics — energizing drug discovery in neurodegenerative diseases.
  • Scorpion Therapeutics — We are developing drugs specifically designed to interact with validated cancer targets with greater selectivity and optimized pharmaceutical properties to improve their safety and efficacy.
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Amgen Ventures
VC Fund · San Francisco, California, United States

Amgen Ventures is a venture capital investment arm of Amgen Inc. specializing in investments in early and later stage companies. The firm primarily invests in the biotechnology sector with a focus on discovering and developing human therapeutics with a focus on oncology, inflammation, hematology, nephrology, metabolic disorders, neuroscience, andcardiovascular therapeutics. In oncology and hematology it focuses on novel therapeutics including signal transduction, cell cycle, and apoptosis; hematopoiesis including anemia, neutropenia, and stem cell mobilization; and supportive care including mucositis and cachexia. In nephrology the firm focuses on renal failure and hyperparathyroidism. For inflammation the firm focuses on rheumatoid arthritis, psoriasis, systemic lupus erythematosus, inflammatory bowel disease, multiple sclerosis, asthma and COPD, and osteoarthritis. Under cardiovascular, it focuses on acute coronary syndromes, dyslipidemia, and heart failure and under metabolic disorders it focuses on diabetes, metabolic syndrome, and osteoporosis. The focus on neuroscience included pain including neuropathic and inflammatory, alzheimer's disease, parkinson's disease, sleep disorder, cognition, and schizophrenia. In discovery research and technology the firm focuses on early-stage drug discovery collaborations, innovative chemical entity collections, diagnostics and biomarkers, novel antibody platforms, assay biologicals and devices, and target-focused structural biology and computational tools. It primarily invests in the North America, Europe, and the United Kingdom. The firm typically invests between $2 million and $3 million per transaction and may invest up to $10 million per company. It prefers to have an ownership stake of less than 15 % in its portfolio companies. Amgen Ventures was founded in 2004 and is based in San Francisco, California with additional offices in Seattle, Washington; Thousand Oaks, California; and Cambridge, Massachusetts.

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Investment focus

  • Biotechnology, Health Care, Therapeutics
  • Series B, Series A, Series C
  • United States, Canada, United Kingdom

Portfolio highlights

  • Casma Therapeutics — Casma Therapeutics is a developer of a natural cellular process of autophagy to open new target areas for drug discovery and development. The company focuses on autophagy system to improve the cellular process of clearing out unwanted proteins, organelles and invading pathogens as well as tries to arrest or reverse the progression of lysosomalstorage disorders, muscle disorders, inflammatory disorders and neurodegeneration, enabling physicians to address unmet medical needs.
  • Feldan Therapeutics — Feldan Therapeutics has developed a patented peptide-based technology platform, the Feldan Shuttle, which enables fast and safe intracellular delivery. The company's mission is to develop leading-edge therapeutic applications based on its proprietary platform, as demonstrated by its current pipeline of clinical programs taking advantage of theunique characteristics of the Shuttle.
  • Mindset Medical — Mindset Medical is a Health Care Company that develops a platform for clinical information. Through their platform physicians will understand patient pain, saves time for providers and patients, they eliminate paper and redundant forms, and allows providers more time for patients. Mindset Medical was founded in 2016 in Phoenix, Arizona.
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Founders Fund
VC Fund · San Francisco, California, United States

Founders Fund is a San Francisco based venture capital firm investing in companies building revolutionary technologies.

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Investment focus

  • Software, Health Care, Information Technology
  • Series A, Seed, Series B
  • United States, United Kingdom, Germany

Portfolio highlights

  • Bev — Bev | zero sugar premium canned wine | crisp, dry & a lil' fizzy
  • Vest — Vest is an app-based brokerage that wants to provide Latin American savers with access to American assets that are differentiated by product, pricing, and content. Latin Americans are known for saving, but many prefer to do so in cash or in zero-interest savings accounts.
  • Enter — Talisman AI uses artificial intelligence to provide auditable and reliable legal drafting for lawyers.
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Illumina Ventures
VC Fund · Foster City, California, United States

We invest in companies that are advancing the field of genomics and pioneering new applications in healthcare, agriculture, environmental science, and personal

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Investment focus

  • Biotechnology, Health Care, Medical
  • Series A, Series B, Series C
  • United States, United Kingdom, France

Portfolio highlights

  • CubaseBio — Cubase Bio is a biotechnology business that focuses on spatial biology tools. It creates solutions for 3D spatial analysis to speed up drug discovery.
  • DeepSeq.AI — Explore DeepSeq.AI - revolutionizing protein screening and drug design with cutting-edge AI. We empower researchers to accelerate discoveries and transform healthcare.
  • Alamar Biosciences — Alamar Biosciences is a proteomics company redefining the limits of Protein Biomarker Detection with unrivaled precision. Learn more about what we offer here.
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Refactor
VC Fund · Burlingame, California, United States

Refactor Capital is an early-stage venture capital firm that invests in founders solving fundamental human problems.

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Investment focus

  • Health Care, Biotechnology, Medical
  • Seed, Series A, Series B
  • United States, United Kingdom, New Zealand

Portfolio highlights

  • Pilgrim — Pioneering a biologically enhanced future for humanity.
  • Causal Labs — Causal Labs provides AI physics models to predict and control the weather.
  • MIIST Therapeutics — Miist Therapeutics is setting a new standard in acute care with inhaled therapies that work in seconds, not hours.
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North Carolina Biotechnology Center
VC Fund · Alexander, North Carolina, United States

The North Carolina Biotechnology Center is a private, non-profit corporation funded by the N.C. General Assembly to strengthen biotechnology research, business and education statewide. The Center is not a site for laboratory research; it works to support job creation in the biotechnology industry.

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Investment focus

  • Biotechnology, Health Care, Medical
  • Debt Financing, Grant, Funding Round
  • United States, United Kingdom

Portfolio highlights

  • Phase — Phase provides 3D-printing medical devices for microfluidics. Phase’s proprietary platform enables PDMS (Sylgard 184) to be 3D printed at a scale and resolution that was previously unattainable.
  • QATCH Technologies — Get the most out of a drop
  • Atlantic Fish Company — Atlantic Fish Co is a cultivated seafood company using cellular agriculture to bring the world sustainable delicious seafood.
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Vivo Capital
VC Fund · Palo Alto, California, United States

The firm is a 25-year-old global investment firm focused on healthcare with approximately $5.8 billion in AUM, which we have invested in over 290 public and private companies worldwide. Headquartered in Palo Alto, California, with offices in Asia. Our team consists of 50 multi-disciplinary professionals, including, physicians, scientists,entrepreneurs, operating executives, and industry experts. The firm operates as a multi-fund investment platform, covering growth equity, private equity including buyout, venture capital, and public equity. Vivo invests broadly in healthcare across all fund strategies, including biotechnology, pharmaceuticals, medical devices, and healthcare services, with a focus on the largest healthcare markets.

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Investment focus

  • Biotechnology, Health Care, Pharmaceutical
  • Series B, Series C, Post-IPO Equity
  • United States, China, United Kingdom

Portfolio highlights

  • Sanegene Bio — Sanegene Bio is currently operating in stealth mode.
  • Clasp Therapeutics — Clasp Therapeutics offers to reach of immuno-oncology with novel precision medicines that enable the immune system to identify and specifically destroy hard-to-treat tumors bearing common driver mutations, regardless of tumor type.
  • Visirna Therapeutics — Visirna Therapeutics to develop and commercialize RNAi therapeutics targeting cardiovascular and metabolic diseases.
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Takeda Ventures
VC Fund · San Diego, California, United States

Takeda Ventures, Inc. (TVI) is the corporate investment arm of Takeda Pharmaceutical Company Limited (TPC). TVI was founded in 2001 and invests in current and future areas of interest for TPC. They are based alongside Takeda’s R&D sites in Cambridge, MA, and San Diego, CA. As a strategic investor, TVI aims to provide support and guidance toentrepreneurs and early-stage companies driving concepts through clinical proof of concept. They also strive to forge active, collaborative interactions that result in synergies with Takeda's considerable R&D resources. Their goal is to build a portfolio of strategic investments, with an immediate emphasis on oncology, gastroenterology, neuroscience, and rare diseases.

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Investment focus

  • Biotechnology, Health Care, Therapeutics
  • Series A, Series B, Funding Round
  • United States, United Kingdom, Israel

Portfolio highlights

  • Be Biopharma — Be Bio is developing a proprietary class of engineered B cells as medicines that unleash the potential of cell therapies in applications beyond cytotoxicity.
  • Degron Therapeutics — Degron Therapeutics is a leading platform company in discovery of molecular glue degraders for cancer treatment.
  • Accipiter Biosciences — Accipiter Biosciences is a biotechnology company.
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Flagship Pioneering
VC Fund · Cambridge, Massachusetts, United States

We create breakthroughs in human health and sustainability and build bioplatform companies . Companies founded

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Investment focus

  • Biotechnology, Health Care, Medical
  • Series B, Series C, Series A
  • United States, Canada, United Kingdom

Portfolio highlights

  • Lila Sciences — Lila Sciences is a platform that uses artificial intelligence to support research in life sciences, chemical sciences, and materials sciences. It develops AI-driven tools and autonomous labs to improve research efficiency and facilitate scientific discoveries. The platform is designed to enhance various aspects of the scientific method andcontribute to advancements in technology and innovation.
  • Montai Therapeutics — Harnessing untapped diverse chemistry with AI-enabled drug discovery to develop breakthrough small molecule medicines for chronic disease.
  • Expedition Medicines — Defining a new era in drug discovery where chemistry rewrites the rules of biology to engage any protein target.
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Digitalis Ventures
VC Fund · New York, New York, United States

Engineering solutions to complex problems in health through venture investment and company creation.

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Investment focus

  • Biotechnology, Health Care, Medical
  • Series A, Series B, Seed
  • United States, United Kingdom, China

Portfolio highlights

  • PetMedix — PetMedix develops next-generation antibody therapies for pets, using advanced biotechnology to create safer, more effective treatments for animal health.
  • Scout Bio — Scout Bio is a biotechnology company that specializes in veterinary, animal health, and gene therapy. The company is driven by its mission is to harness the genetic revolution transforming human medicine to deliver the future of veterinary medicine. Scout Bio was founded in 2016 and headquartered in Pennsylvania, United States.
  • Terray Therapeutics — Everything small molecule drug discovery should be.
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DCVC Bio
VC Fund · San Francisco, California, United States

DCVC backs companies using deep tech to solve the biggest problems that matter. Our investments address climate change, human health, the operations of physically intensive industries, defense, security, space, and more.

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Investment focus

  • Biotechnology, Therapeutics, Medical
  • Series A, Seed, Series B
  • United States, United Kingdom, Canada

Portfolio highlights

  • CH4 Global — CH4 Global is an aquaculture solutions provider dedicated to urgently impacting climate change at scale. Lead by a world-class team of senior business builders, scientists and entrepreneurs, the company is initially leveraging proven science and technology for growing seaweed into innovative new livestock supplement that reduces methane produced bycows by up to 90%. Among early investors are a select group of prominent family offices and private investors. CH4 Global have also received non-dilutive capital support from government organizations from around the world. CH4 Global is a Delaware corporation based in Henderson, NV.
  • Totus Medicines — Applying revolutionary chemical biology technologies to create life-changing covalent therapeutics for untreatable diseases.
  • Novome Biotechnologies — Novome Biotechnologies, Inc. is a biotechnology company focused on engineering defined activities into the human gut microbiota to treat chronic diseases. The Company has developed the first-ever platform for controlled colonization of the gut with engineered bacteria, enabling first-in-class living therapeutics: Genetically Engineered MicrobialMedicines (GEMMs). Novome is utilizing its proprietary GEMMs platform in its lead preclinical program in hyperoxaluria, which is focused on the development of a therapeutic strain of bacteria that degrades oxalate to prevent the formation of kidney stones. Efforts are also directed to the expansion of its proprietary synthetic biology platform into additional indications.
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