Top 50 Startup Investors in Puerto Rico in May 2026

Portfolio highlights

• Cropify — Eliminating subjective testing from the classification process using AI and machine learning. Cropify.io
• Flint — Introducing a new battery technology designed for sustainable energy solutions. Explore our innovation and its impact on the future of energy.
• Cellivate Technology — Startup, with proprietary platform technologies and products that enable cellular meat companies to accelerate the growth of cells

Portfolio highlights

• ARO Network — ARO Network is a decentralized edge cloud platform focusing on power peer-to-peer content delivery.
• Silhouette Exchange — Silhouette is a privacy-focused decentralized trading protocol integrated with the Hyperliquid ecosystem.
• Impossible Cloud Network — Impossible Cloud Network (ICN) is the foundational layer for the next-generation internet — a decentralized, composable cloud infrastructure serving AI, Web3, and enterprise applications. Unlike siloed DePIN projects or centralized incumbents, ICN delivers a high-performance, permissionless platform integrating storage, compute, and networking.With $31M in total funding, enterprise-grade architecture, 1,000+ B2B clients, and 28,000+ hypernodes sold, ICN is uniquely positioned to outcompete traditional cloud services and power the future of decentralized infrastructure. ICN is community-owned, performance-optimized, and regulation-aligned — bridging real-world adoption with blockchain innovation.

Portfolio highlights

• Quibble — Price Optimization and Revenue Management Software and Consulting For Vacation Rentals & Alternative Accommodations - We created Quibble to address the gap in the market between the simple rules-based software applications currently available and a truly science-based optimization. Quibble bundles our software with a full service offering togive our clients complete Pricing Ease of Mind. With many years of revenue management experience in the travel and hospitality industries, we know the pains and uncertainty revenue management brings. At Quibble, we aim to increase your revenue performance by engineering and implementing your custom pricing strategy while developing long-lasting partnerships.

Portfolio highlights

• Valpas — Valpas is the hygiene protocol that reassures your future guests and keeps your hotel clean from the most uncontrollable: bed bugs
• Retorna — Retorna is an application for online money transfers and payments.
• Moonflow — Mejora tus procesos de cobranzas y ahorra hasta un 75%. Software de Gestion de Cobranzas para Empresas,

Portfolio highlights

• Luminoah — Discover Luminoah Flow, the world's smallest enteral nutrition delivery system designed for your active lifestyle. Empower your nutrition journey today.
• Cloverleaf AI — Transforming 1.5 million government meetings into 10 minutes of actionable information daily to help companies gain an edge with RFPs.
• Apira Technologies — Apira Technologies provides a persona platform that enables users to pilot photorealistic avatars and scenes over desktop video conference systems and streaming platforms.

Portfolio highlights

• IMUA — IMUA is a Layer 1 blockchain that provides shared security by combining decentralized security from well-known blockchains.
• Exocore — Exocore is the layer one blockchain for aggregated security.

Portfolio highlights

• Ballet — Ballet Crypto is a companion mobile app, which enables sending of cryptocurrency, checking market value and activating additional currencies. The use of the mobile app is completely optional, as you do not need it to receive and store your cryptocurrency safely.
• VirgoCX — We make crypto trading safe, easy, and affordable for Canadians. Buy Bitcoin, Ethereum and 60+ Cryptocurrencies with competitive pricing, Free cash in and out, instant funding, and timely customer service.
• MIDL — MIDL is a digital finance company that offers EVM compatibility, functionality of Ethereum dApps to Bitcoin users.

Portfolio highlights

• IMUA — IMUA is a Layer 1 blockchain that provides shared security by combining decentralized security from well-known blockchains.
• Exocore — Exocore is the layer one blockchain for aggregated security.
• Doppler Finance — Doppler Finance is a yield-earning platform that unlock earning opportunities within the XRPL ecosystem

Portfolio highlights

• KINO — KINO is a film production company that brings fans behind the scenes of their favorite hollywood films.
• DeepNode AI — DeepNode connects researchers, data scientists, and enterprises into one transparent, verifiable network for building real-world AI. DeepNode AI a technology service provider focusing on decentralized AI infrastructure,
• Renaissance — Renaissance allows artists to amplify their streaming traction and tap into a community of their super fans.

Portfolio highlights

• Everlyn — Everlyn is a Web3 video AI model that generates a decentralized infrastructure layer for autonomous video.
• Voyage — Voyage AI is an AI infrastructure project building the first GEOFi network to make AI-generated content citable.
• Cold River Games — Crystalfall is an upcoming free online action RPG with customizable skills and an endless endgame, set in a steampunk world.

Portfolio highlights

• IMUA — IMUA is a Layer 1 blockchain that provides shared security by combining decentralized security from well-known blockchains.
• Exocore — Exocore is the layer one blockchain for aggregated security.
• Voyage — Voyage AI is an AI infrastructure project building the first GEOFi network to make AI-generated content citable.

Portfolio highlights

• Luminoah — Discover Luminoah Flow, the world's smallest enteral nutrition delivery system designed for your active lifestyle. Empower your nutrition journey today.
• Cloverleaf AI — Transforming 1.5 million government meetings into 10 minutes of actionable information daily to help companies gain an edge with RFPs.
• Apira Technologies — Apira Technologies provides a persona platform that enables users to pilot photorealistic avatars and scenes over desktop video conference systems and streaming platforms.

Portfolio highlights

• RobinFood — RobinFood is the leader in cloud-restaurants in Latin America with presence in Colombia, Brazil and Mexico. RobinFood was founded in 2018
• PRoduce — PRoduce! is a multi-platform marketplace for local produce. It aims to connect local producers with buyers, including chefs, restaurants, hotels, and direct customers, to decrease the Island’s imported goods. It was founded in 2018 and is based in San Juan, Puerto Rico.
• Afia — Afia Falafel and Kibbeh are made from our family recipes and are prepared in the traditional way, with only simple ingredients, and no preservatives. Available frozen, Afia products fit a range of dietary needs, including gluten-free, halal, vegetarian and vegan options.

Portfolio highlights

• Novastro — Novastro is a Layer 2 chain for RWAs powered by AI that integrates MoveVM and EigenLayer AVS, delivering Ethereum-level security and Move’s scalability to unlock tokenised yield opportunities across RWAs & DeFi protocols.
• Shiba Inu Coin — SHIB is more than a meme it's a decentralized movement. 1.5M+ holders, 3.8M+ followers, built by the community. Join the ShibArmy.
• Router Protocol — Router Protocol is a Cross Chain Bridge. Currently live on Ethereum, Polygon, and more. Building an interoperable cross chain future of the blockchain ecosystem.

Portfolio highlights

• Tea — Learn more about the tea protocol and how to unlock the rewards for previous and future open-source software contributions.
• Web3Auth — Web3Auth is simple, non-custodial auth infrastructure that enables Web3 wallets and applications to provide seamless user logins for both mainstream and native Web3 users.
• NexGen Cloud — Discover NexGen Cloud's innovative AI cloud solutions designed for seamless scalability, high performance and robust security. Lead AI innovation with NexGen Cloud.

Portfolio highlights

• IMUA — IMUA is a Layer 1 blockchain that provides shared security by combining decentralized security from well-known blockchains.
• Codatta — Unlock the value of your data securely and transparently. Codetta empowers freelancers to earn passive income by sharing your data with trusted entities. Take control and start earning today!
• BIO Protocol — The BIO Protocol (BIO) allows onchain scientific communities to fund, build, and co-own research and products in specific biomedical domains including lifespan, brain health, and rare disorders. BIO, founded by senior VitaDAO members, empowers worldwide communities of scientists, patients, and investors to take science into their own hands andbring solutions to life more effectively than traditional pharmaceutical companies.

Portfolio highlights

• IMUA — IMUA is a Layer 1 blockchain that provides shared security by combining decentralized security from well-known blockchains.
• Wert — Making purchasing of NFTs seamless and not requiring users to have crypto.
• Outland — Criticism and conversations about art, technology, and NFTs

Portfolio highlights

• Hyperion — Join the Hyperion waitlist today to access the only bank account your business will ever need.

Portfolio highlights

• Kaia — Kaia is a public blockchain that utilizes Byzantine Fault Tolerance (BFT) for enhanced reliability and performance.
• Variational — Go long or short with leverage on memecoins, DEX pairs, pre-launch tokens, points markets, and more.
• Hyperdrive — Hyperdrive delivers investment growth strategies utilizing a portfolio-centered approach.

Portfolio highlights

• Vend Park — Unlock the true value of your parking asset with a fully digital parking access and revenue control system
• Wolf — Get all the tools and expertise you need to launch your own branded on-demand staffing platform, SpaaS and apps.
• Dataplor — Leveraging machine learning, AI, and human capital, dataplor delivers verified international places data to the world's leading companies.

Portfolio highlights

• Quibble — Price Optimization and Revenue Management Software and Consulting For Vacation Rentals & Alternative Accommodations - We created Quibble to address the gap in the market between the simple rules-based software applications currently available and a truly science-based optimization. Quibble bundles our software with a full service offering togive our clients complete Pricing Ease of Mind. With many years of revenue management experience in the travel and hospitality industries, we know the pains and uncertainty revenue management brings. At Quibble, we aim to increase your revenue performance by engineering and implementing your custom pricing strategy while developing long-lasting partnerships.
• ClassCalc — Students can use their smartphones instead of using or buying a TI calculator, and teachers can ensure they only use the ClassCalc calculator app in class. We believe students and teachers should have a choice other than the same expensive, difficult to learn and use dedicated-purpose TI calculator they have been forced to use for decades.ClassCalc provides a multi-subject math calculator with scientific, graphing, and matrix functionality in an easy-to-use smartphone app. Teachers are able to lock down the student’s phone to only the ClassCalc app for class time, quizzes, tests… no cheating or outside distractions (social media, texting etc).
• Turno, formerly TurnoverBnB — Find now a local Airbnb cleaning service; automatically schedule your existing cleaners. Integrated with all reservations platforms and channel managers.

Portfolio highlights

• Qredo — Qredo is a cross-chain protocol for asset managers and traders active in the digital asset markets. Using our institution-grade, layer 2 infrastructure, investors can now hold all their crypto assets securely in one place, with unlocked access to a wide range of liquidity venues and DeFi yield opportunities.
• AuDIGENT — AuDIGENT is an audience intelligence platform that provides brands with actionable data, analytics and insights that optimize the targeting, engagement and ROI of online, mobile and social video ads while opening up new revenue streams for artists and other social influencers. AuDIGENT's platform allows brands to discover, monitor and targetaudiences that drive media performance. AuDIGENT's platform empowers artists and influencers to tap into the tools and technology needed to monetize their social influence and fan engagement. AuDIGENT's executives, data scientists, developers and operations team are in New York, Philadelphia and London. For more information visit AuDIGENT.com
• Tea — Learn more about the tea protocol and how to unlock the rewards for previous and future open-source software contributions.

Portfolio highlights

• Streem — Easy AR-powered remote video support & communication platform with AI data capture to get the job done from anywhere. Streem is better than being there.
• Momentum — Finally, a real solution for major gift fundraising. Powered by AI.
• Midsummer Studios — Midsummer Studios is a independent, well-funded and committed to building a new kind of studio.

Portfolio highlights

• Transak — Transak offers a simple integration to allow your users to buy more than 100+ cryptocurrencies with credit/debit cards, or bank transfers in more than 120+ countries.
• Agents World — Agents World operates as an web3 AI firm.
• Ooga Booga — Multichain Liquidity Aggregator

Portfolio highlights

• CELL Studio — A blockchain software development company with a dedicated focus on the BTC ecosystem, committed to advancing the Nervos BTCKB initiative
• Avalon Finance — Institutional Bitcoin-backed lending, borrowing, earning, and liquidity. Fully on-chain and regulatory-compliant.
• Stoneblade Entertainment — Stoneblade Entertainment operates as a publisher of strategy games.

Portfolio highlights

• CB International Bank — CBiBank is a U.S. commercial bank with a U.S. banking license,Committed to providing one-stop global financial solutions for export companies, import companies, cross-border e-commerce, overseas companies and individual investor users, including overseas bank account opening, cross-border remittance, cross-border payment, global trade collection, etc., Offshore bank account opening is efficient and fast, international remittances are safe, and bilingual and cross-time zone online services are supported.

Portfolio highlights

• Abartys Health — abartysHealth provides simple, smart and secure healthcare data management solutions for life sciences companies, health plans and patients

Portfolio highlights

• GAM3S.GG — Discover 1,500+ games with honest reviews, expert guides, and daily gaming news across PC, console, and mobile. Find your next favorite game on Steam, Epic Games, PlayStation, Xbox, and Nintendo.
• CARV — CARV enables AI Beings to live, evolve, and govern as sovereign intelligences on-chain; not as tools, but as beings that act, learn, and lead.
• Nest Wallet — A Wallet Built for Traders

Portfolio highlights

• Due — Discover our global payment platform. Powered by open, decentralised and interoperable networks.
• Freename — Redefining Web3 Naming System. Web3 Registrar: custom TLDs and Domains
• BIO Protocol — The BIO Protocol (BIO) allows onchain scientific communities to fund, build, and co-own research and products in specific biomedical domains including lifespan, brain health, and rare disorders. BIO, founded by senior VitaDAO members, empowers worldwide communities of scientists, patients, and investors to take science into their own hands andbring solutions to life more effectively than traditional pharmaceutical companies.

Portfolio highlights

• Magma — Magma is a decentralized liquid staking protocol built on the Monad Network, an Ethereum-compatible Layer 1 blockchain.
• Rover — Rover is a liquid staking protocol on Botanix that exchanges Bitcoin for rovBTC.
• Neptune Protocol — Neptune Protocol is a decentralized lending platform. It enhances capital efficiency by enabling customers to obtain liquidity in a secure manner.

Portfolio highlights

• Wirelane — Wirelane is a full service provider in the field of electric mobility. The company is currently active in 5 countries (D, F, S, NL, CH) and has experience with large industrial customers (VW, Vattenfall, Bouygues and others). In addition to their software solutions, they also offer specially developed charging stations that set standards throughthe use of advanced technology such as radar sensors and tap payment. The company works with customers from all industry sectors to develop solutions for tomorrow’s mobility needs. Wirelane is one of Europe’s leading specialist providers of hardware, software and app solutions.
• Charquiqui — Charquiqui specializes in manufacturing red meat products intended to offer cured meat snacks. It offers retail products and packages of red meat that contains beef bites, cured in natural brine, and partially dehydrated on grills.
• 13 Fronteras — Latin American Cuisine

Portfolio highlights

• Tea — Learn more about the tea protocol and how to unlock the rewards for previous and future open-source software contributions.
• Casper Labs — Casper Labs powers scalable, secure & decentralized blockchain solutions for businesses, with the most flexible and customizable architecture on the market

Portfolio highlights

• Nada — Finance, Invest and Bank your real estate.
• DigiBuild — DigiBuild develops a construction management software that utilizes blockchain technology. It captures transactions from all of the different systems being utilized on the project and puts them into a filterable, searchable, and comparable project timeline to remove the waste and fraud for better data insights and decision making that will stopbudget overages.
• Upright — Meet Upright, the good for you go-to. Our first product is a category-defining high-protein, allergen-free Instant Oatmilk in three creamy, delicious flavors: original, vanilla, and chocolate. Each tasty cup of our oatmilk packs the same key nutrients as dairy, without the unwanted allergens or environmental impact.

Portfolio highlights

• Hyperion — Join the Hyperion waitlist today to access the only bank account your business will ever need.

Portfolio highlights

• Mytra — Supercharged Industrial Productivity with Bots, Software, and Cells
• Tokemak — Automated DeFi Yield Farming & Liquidity Management
• Coop Records — Coop Records Music

Portfolio highlights

• Hydrolix — Hydrolix is an early-stage startup with an ambition to change the economics of high density data. The company develops a query service technology intended to process petabyte-scale time series data.Hydrolix's cloud-based query service utilizes proprietary compression and indexing technology, allowing customers to process sub-secondinteractive queries at a fraction of the cost of other existing services.
• MQube — MQube: Next-generation lending platform offering fast, automated mortgage solutions with real-time decisioning and built-in compliance.
• SoterAI — Transform workplace safety with AI-powered virtual loss control. Conduct audits in hours, analyze claims automatically, and provide insureds with comprehensive risk reduction tools.

Portfolio highlights

• Wrisk — The Wrisk Platform helps brands co-create, launch and operate customised insurance products that can be launched rapidly and at scale.
• Hokodo — Boost sales and improve customer experience with B2B Buy Now Pay Later options at checkout. Hokodo's B2B BNPL solution is the modern way to offer trade credit.
• Parametrix — Parametrix cloud insurance protects companies against any loss due to cloud outages. A simple, essential add-on to any cyber program.

Portfolio highlights

• Sepana — Sepana develops search technologies designed to make it easy for people, communities, applications, and protocols to discover Web3 content. Founded in 2021, Sepana's API allows developers to build search-as-a-service functionality directly into their apps.
• Mauve — Fully Compliant, Non-Custodial Exchange
• Optic — Optic monitors blockchains to reveal the origins of any NFT and how it’s been reimagined, remixed, or copied.

Portfolio highlights

• Kapkap — Kapkap is a web3 platform that uses AI for attention based value distribution in gaming.
• BullPerks — BullPerks is a community of like-minded individuals who want to leverage their power and invest together in the best projects on equal terms with VCs.
• Mythic Protocol — The Central Hub for Mythic Operatives to conduct their operations

Portfolio highlights

• TACEO — TACEO refers to MPC encrypted compute for Web3.
• Due — Discover our global payment platform. Powered by open, decentralised and interoperable networks.
• Freename — Register Web3 domains, custom TLDs, or import domains. Secure your digital identity today.

Portfolio highlights

• Axal — Earn competitive returns on your crypto with institutional-grade DeFi strategies, non-custodial security, and seamless user experience.
• Hemi Labs — Hemi (https://hemi.xyz) is a modular protocol that integrates Bitcoin and Ethereum to amplify and extend the core capabilities of the two leading blockchain networks. This offers a novel perspective on blockchain interoperability and scaling by approaching Bitcoin and Ethereum as components of a single supernetwork. The result providessecurity that exceeds that of Bitcoin (“superfinality”) and new levels of blockchain programmability, portability, and potential. Hemi was co-founded by Jeff Garzik (former Bitcoin core developer) and Max Sanchez (inventor of the Proof-of-Proof consensus protocol), and is surrounded by a team of renowned blockchain engineers, strategic partners and investors.
• Nexio — Nexio is a bitcoin scaling solution platform that helps to improve cryptocurrency's scalability by using parallelizing Bitcoin rollouts.

Portfolio highlights

• Exocore — Exocore is the layer one blockchain for aggregated security.
• Exabits AI — Exabits' network of GPUs ranges from consumer-grade to H100s, offering the most cost-effective compute because we are obsessed with innovating performance.

Portfolio highlights

• Calculum — Calculum helps you with your core business needs: Optimizing working capital, generating cash flow, and improving margins, while reducing the risk of financial supply chain disruption.
• Zion — Join our mission in creating the last platform you will ever build
• BridgePort — SaaS, Fintech, Middleware, Trading Infra

Portfolio highlights

• Tea — Learn more about the tea protocol and how to unlock the rewards for previous and future open-source software contributions.

Portfolio highlights

• JAN3 — JAN3 provides technologies and solutions for individuals, enterprises, and nation-states to prepare for the future built on Bitcoin.
• Vida — Vida is the AI Agent Operating System for enterprises. Build, deploy, and manage AI agents that call, text, email, and chat at scale with no-code tools.
• OrdinalsBot — We make it easy to inscribe ordinals. Like, really easy.

Portfolio highlights

• Hyperion — Join the Hyperion waitlist today to access the only bank account your business will ever need.

Portfolio highlights

• Rhuna — Rhuna is an AI and blockchain platform that transforms event management with NFT ticketing and token rewards.
• Lympid — We believe that anyone should have access to the amazing opportunities found on the blockchain, from DeFi protocols (aave, compound, yearn…) to Crypto Indexes, there's so much to discover! At Lympid you will be able to do it all easily in the same app, and directly through EUR.
• BRC20.com — BRC20.com is a decentralized finance infrastructure that incorporates features allowing users to engage in the cryptocurrency market.

Portfolio highlights

• Tea — Learn more about the tea protocol and how to unlock the rewards for previous and future open-source software contributions.

Portfolio highlights

• Civil — A starter blog demonstrating what Gatsby can do.
• Trustology — FCA registered & award-winning custodian Trustology safeguards & administers cryptoassets across blockchains, exchanges & DeFi protocols for institutions.
• SharpLink — SharpLink is an online technology company that works with sports leagues, fantasy sports sites, and sports media companies.

Portfolio highlights

• Kiwi — Kiwi is a fintech dedicated to helping Latinos build credit history and improve financial literacy.
• Hyperion — Join the Hyperion waitlist today to access the only bank account your business will ever need.
• Ole Insurance Group — Ole Insurance Group focuses on offering protection and well-being products and services through technology. Ole Insurance Group was founded in 2021 and was headquartered in Puerto Rico.