Top 50 Startup Investors in Puerto Rico (September 2026)

Portfolio highlights

• Toteat — Headquarters located at Vitacura 2771, of. 504, Las Condes, Santiago de Chile
• Kiwi — Kiwi is a leading platform that helps Latinos living in the US, who may have limited credit data and access to capital, build credit history through unsecured lines of credit and alternative credit builder programs. As the fastest-growing minority segment in the US, the Latino market is expected to reach over 100 million in the next few decades.Our mission is to empower Latinos by providing tools and resources to establish credit, access capital and save money.
• BackChannel — BackChannel is an online B2B platform for inventory transactions and for buying and selling online goods.

Portfolio highlights

• Kiwi — Kiwi is a leading platform that helps Latinos living in the US, who may have limited credit data and access to capital, build credit history through unsecured lines of credit and alternative credit builder programs. As the fastest-growing minority segment in the US, the Latino market is expected to reach over 100 million in the next few decades.Our mission is to empower Latinos by providing tools and resources to establish credit, access capital and save money.
• Hyperion — Join the Hyperion waitlist today to access the only bank account your business will ever need.
• Ole Insurance Group — Ole Insurance Group focuses on offering protection and well-being products and services through technology. Ole Insurance Group was founded in 2021 and was headquartered in Puerto Rico.

Portfolio highlights

• Knit — Knit is an AI-Native Research Agency that combines the rigor and expertise of a traditional agency with the speed and efficiency of AI.
• Knit — Knit helps researchers run agency-quality quant + qual research at DIY costs, by taking the most time-intensive research tasks off their plate through Researcher-Driven AI.
• Buildforce — Amping up America's electrical workforce

Portfolio highlights

• Luminoah — Discover Luminoah Flow, the world's smallest enteral nutrition delivery system designed for your active lifestyle. Empower your nutrition journey today.
• Cloverleaf AI — Cloverleaf AI turns 1.5 million government meetings into early buying signals, so you reach buyers before the RFP. Government sales intelligence for B2G sellers.
• Apira Technologies — Apira Technologies provides a persona platform that enables users to pilot photorealistic avatars and scenes over desktop video conference systems and streaming platforms.

Portfolio highlights

• JAN3 — JAN3 provides technologies and solutions for individuals, enterprises, and nation-states to prepare for the future built on Bitcoin.
• Vida — Vida is the AI Agent Operating System for enterprises. Build, deploy, and manage AI agents that call, text, email, and chat at scale with no-code tools.
• OrdinalsBot — We make it easy to inscribe ordinals. Like, really easy.

Portfolio highlights

• TuBanc — TuBanc is a fintech app that provides productive credit for purchasing cars and motorcycles.
• MBQ Pharma — Precision Targeting GTPases in Cancer, Autoimmunity and Fibrosis Precision Targeting GTPases in Cancer, Autoimmunity and Fibrosis MBQ-167 Our lead compound, MBQ-167, is a first-in-class therapeutic which simultaneously inhibits both Rac and CDC42, removing pre-existing metastases. MBQ-167 is currently in its Phase-1 study. Prevention of Metastatic Growth and
• Zero Damage — we manufacture high-performance modular buildings.

Portfolio highlights

• Inaam — impact investing made simple. pick your values, build a real portfolio, track where your money goes. $10/month. ASIC-regulated. built for 18-30s.
• PayToMe.co — PayToMe.co offers innovative and secure payment solutions including text-to-pay, digital invoicing, and digital checkbook services.
• Kybele's Garden — Kybele's Garden focus on algae-based bioponics and algae fermentation methods. Their differentiation strategy boosts harvest yield, source efficiency, and functional content, while improving sensory attributes and shelf life. These technologies can be used in agrifood and skin care, and integrated into existing producers' systems.

Portfolio highlights

• GAMES.GG — Discover 1,500+ games with honest reviews, expert guides, and daily gaming news across PC, console, and mobile. Find your next favorite game on Steam, Epic Games, PlayStation, Xbox, and Nintendo.
• CARV — CARV enables AI Beings to live, evolve, and govern as sovereign intelligences on-chain; not as tools, but as beings that act, learn, and lead.
• Nest Wallet — A Wallet Built for Traders

Portfolio highlights

• Neosoul — NeoSoul uses an open architecture with autonomous agents operating under user-defined constraints to link agent intelligence, deterministic capital controls, and verifiable market execution.
• ORO — ORO is an AI-powered DeFi companion that lets users manage, trade, stake, lend, and research crypto assets through natural-language conversations, ORO aims to simplify onchain finance by bringing portfolio management and DeFi actions into one conversational interface.
• Fortune Protocol — Fortune Protocol brings the age- old tradition of fortune cookies to the modern prediction market.

Portfolio highlights

• IMUA — Follow us @imua
• Exocore — Exocore is the layer one blockchain for aggregated security.
• Valinor — Institutional capital solutions at the intersection of credit and blockchain

Portfolio highlights

• Techdollar — Techdollar operates a private credit platform that originates and underwrites loans secured against private company equity. The service enables late-stage startup founders, employees, and institutional investors to unlock liquidity from their shares without triggering a taxable sale or losing long-term upside.
• Optimum — The Universal Data Acceleration Network | Powered by RLNC
• Doppler Finance — Rebuilding Capital Markets for the Tokenized Era.

Portfolio highlights

• IMUA — Follow us @imua
• Exocore — Exocore is the layer one blockchain for aggregated security.
• Voyage — The full stack AI GTM solution. We help your brand grow on autopilot.

Portfolio highlights

• Convelio — Convelio is a global logistics startup specialized in bulky, fragile and high-value items.
• Parametrix — Parametrix cloud insurance protects companies against any loss due to cloud outages. A simple, essential add-on to any cyber program.
• Sherpa.ai — Secure AI. Private Data. Sovereign Intelligence. Sherpa.ai platform enables secure distributed AI deployments across enterprises, governments, and regulat

Portfolio highlights

• AEON — Powering #agenticeconomy #x402 | AEON is settlement layer bridging autonomous AI interactions (A2A & A2M) with real-world value flows. Backed by @yzilabs $AEON
• Slinky Network — Slinky Network provides an on-chain marketplace and payment protocol that connects AI agents and applications with third-party APIs. The company offers the SlinkyLayer platform, which wraps developer endpoints as discoverable skills and exposes them through an x402 pay-per-execution interface. Each API call triggers a non-custodial on-chainmicropayment, settling in the same request loop using networks such as Base and BNB Chain. Developers set prices, earn a defined revenue share, and receive instant payouts to their wallets without subscriptions or custodial holds. AI agents authenticate via wallet signatures, enabling autonomous, machine-to-machine access and payment without traditional logins or credit cards. The platform also records call ratings on-chain to provide portable, verifiable reputation for services.
• Shanghai Molian Technology — Shanghai Molian Technology is an intelligent agent communication infrastructure platform

Portfolio highlights

• Grupo Felcon — Grupo Felcon is a Autodealership company.
• Hipódromo Camarero — Camarero Race Track Corporation is the only Puerto Rican company that runs Hipódromo Camarero. Hipódromo Camarero began its strategic strategy to upgrade its facilities and overall operations.
• Casa Bella Senior Living Resort — Casa Bella Senior Living Resort offers personalized attention to help seniors improve their quality of life and well-being.

Portfolio highlights

• SOLX — SOLX is a manufacturing company that develops and retails solar panels.

Portfolio highlights

• Kiwi — Kiwi is a leading platform that helps Latinos living in the US, who may have limited credit data and access to capital, build credit history through unsecured lines of credit and alternative credit builder programs. As the fastest-growing minority segment in the US, the Latino market is expected to reach over 100 million in the next few decades.Our mission is to empower Latinos by providing tools and resources to establish credit, access capital and save money.
• Hyperion — Join the Hyperion waitlist today to access the only bank account your business will ever need.

Portfolio highlights

• Kapkap — Kapkap is a web3 platform that uses AI for attention based value distribution in gaming.
• Almanak — Almanak is a decentralized finance (DeFi) smart agent platform that harnesses the power of artificial intelligence to automate, optimize, and intelligently manage a wide range of DeFi investment strategies. It enables users to create and deploy automated DeFi trading and risk-management strategies through coordinated AI agents. It provides anenvironment where AI handles strategy coding, backtesting across thousands of Monte Carlo simulations, optimization, risk monitoring, deployment via non-custodial Safe-based multisig accounts, and real-time performance monitoring with alerting capabilities. The platform supports seamless interaction with multiple blockchains and protocols via an LLM-powered interface.Almanak targets active DeFi participants, developers building financial applications, investment professionals, and users seeking automated portfolio insights. It emphasizes enhanced automation, continuous strategy execution, and adaptive automation driven by emerging AI techniques to respond to evolving market conditions.
• Open Campus — The Open Campus is a community-driven protocol that leverages the power of blockchain and invites all to build the future of education by putting the power of learning back in the hands of educators, students, and the community.

Portfolio highlights

• Wirelane — Driven by the mission "We empower people to move towards a clean future", Wirelane has been designing sustainable mobility since 2016 and is developing innovative complete solutions for the construction, operation, and marketing of charging infrastructure. Wirelane provides its customers with all the necessary service modules, rangingfrom cutting-edge charging technology to a digital management and billing platform, as well as comprehensive installation and operation services.
• Flashcookie — Flashcookie is an on-demand merchandise for independent artists based in Buenos Aires, Argentina.
• Solve Therapeutics — Solve Therapeutics is a biopharmaceutical company that develops Antibody Drug Conjugate and Bispecific Therapeutics. The company was founded in 2021 and is headquartered in Belmont, California.

Portfolio highlights

• Chomp — Chomp is a social network platform that focuses on on question-and-answer with prediction-based systems.
• Techdollar — Techdollar operates a private credit platform that originates and underwrites loans secured against private company equity. The service enables late-stage startup founders, employees, and institutional investors to unlock liquidity from their shares without triggering a taxable sale or losing long-term upside.
• ARO Network — ARO Network is a decentralized edge cloud platform focusing on power peer-to-peer content delivery.

Portfolio highlights

• Quibble — Price Optimization and Revenue Management Software and Consulting For Vacation Rentals & Alternative Accommodations - We created Quibble to address the gap in the market between the simple rules-based software applications currently available and a truly science-based optimization. Quibble bundles our software with a full service offering togive our clients complete Pricing Ease of Mind. With many years of revenue management experience in the travel and hospitality industries, we know the pains and uncertainty revenue management brings. At Quibble, we aim to increase your revenue performance by engineering and implementing your custom pricing strategy while developing long-lasting partnerships.

Portfolio highlights

• RobinFood — RobinFood is the leader in cloud-restaurants in Latin America with presence in Colombia, Brazil and Mexico. RobinFood was founded in 2018
• Jiant — Jiant has transparency and sustainability standards. The company offers gluten, sugar substitutes, natural flavors, preservatives, concentrates, and a lot of sugar. The company uses tea, botanicals, and real fruit to create clean-ingredient hard tea, hard kombucha, and cocktail-inspired RTDs.
• Afia — Afia Falafel and Kibbeh are made from our family recipes and are prepared in the traditional way, with only simple ingredients, and no preservatives. Available frozen, Afia products fit a range of dietary needs, including gluten-free, halal, vegetarian and vegan options.

Portfolio highlights

• Bio.xyz — Biotech's new financial layer.
• Recall Labs — Textile is building new digital experiences by focusing on user privacy, transparency, and decentralization.
• Blackbird — We believe the next great hospitality technology platform should connect restaurants and their customers directly, in meaningful and ongoing ways. Blackbird is founded by a team with a passion for restaurants and a track record of using technology to solve problems.

Portfolio highlights

• Abartys Health — abartysHealth provides simple, smart and secure healthcare data management solutions for life sciences companies, health plans and patients
• San Jorge Children & Women's Hospital — San Jorge Children & Women's Hospital provides health care to children and women and enables excellent services to all patients.

Portfolio highlights

• Rilla — Demonstrating 90% reduction in cost-to-serve for live-streaming, Rilla is rewiring the content economy, directing the value generated back to creators and their communities.By leveraging audience bandwidth and rewarding them with ownership in the network, the savings are equivalent to a free month subscription every year for a moderate level ofviewership.Founded by the technical founders behind Altered State Machine, acquired for 214m. Together for 5+ ventures, collectively raising 130m+ and valued at 1b+.
• Osmo — Osmo is a payment company that helps people to send and receive money immediately.
• Uniblock — Uniblock helps connect developers with Web3 using our APIs and services. Our developers use Uniblock because of how easy it is to integrate into exciting applications. Try it for free today!

Portfolio highlights

• Kaia — Kaia is a public blockchain that utilizes Byzantine Fault Tolerance (BFT) for enhanced reliability and performance.
• Variational — Go long or short with leverage on memecoins, DEX pairs, pre-launch tokens, points markets, and more.
• Hyperdrive — Hyperdrive delivers investment growth strategies utilizing a portfolio-centered approach.

Portfolio highlights

• Vend Park — Unlock the true value of your parking asset with a fully digital parking access and revenue control system
• Wolf — Get all the tools and expertise you need to launch your own branded on-demand staffing platform, SpaaS and apps.
• Dataplor — Leveraging machine learning, AI, and human capital, dataplor delivers verified international places data to the world's leading companies.

Portfolio highlights

• Transak — Transak offers a simple integration to allow your users to buy more than 100+ cryptocurrencies with credit/debit cards, or bank transfers in more than 120+ countries.
• Agents World — Agents World operates as an web3 AI firm.
• Ooga Booga — Multichain Liquidity Aggregator

Portfolio highlights

• CELL Studio — A blockchain software development company with a dedicated focus on the BTC ecosystem, committed to advancing the Nervos BTCKB initiative
• Avalon Finance — Institutional Bitcoin-backed lending, borrowing, earning, and liquidity. Fully on-chain and regulatory-compliant.
• Stoneblade Entertainment — Stoneblade Entertainment operates as a publisher of strategy games.

Portfolio highlights

• IMUA — IMUA is a Layer 1 blockchain that provides shared security by combining decentralized security from well-known blockchains.
• Codatta — Unlock the value of your data securely and transparently. Codetta empowers freelancers to earn passive income by sharing your data with trusted entities. Take control and start earning today!
• BIO Protocol — The BIO Protocol (BIO) allows onchain scientific communities to fund, build, and co-own research and products in specific biomedical domains including lifespan, brain health, and rare disorders. BIO, founded by senior VitaDAO members, empowers worldwide communities of scientists, patients, and investors to take science into their own hands andbring solutions to life more effectively than traditional pharmaceutical companies.

Portfolio highlights

• Due — Discover our global payment platform. Powered by open, decentralised and interoperable networks.
• Freename — Redefining Web3 Naming System. Web3 Registrar: custom TLDs and Domains
• BIO Protocol — The BIO Protocol (BIO) allows onchain scientific communities to fund, build, and co-own research and products in specific biomedical domains including lifespan, brain health, and rare disorders. BIO, founded by senior VitaDAO members, empowers worldwide communities of scientists, patients, and investors to take science into their own hands andbring solutions to life more effectively than traditional pharmaceutical companies.

Portfolio highlights

• Rhuna — Rhuna is an AI and blockchain platform that transforms event management with NFT ticketing and token rewards.
• Lympid — We believe that anyone should have access to the amazing opportunities found on the blockchain, from DeFi protocols (aave, compound, yearn…) to Crypto Indexes, there's so much to discover! At Lympid you will be able to do it all easily in the same app, and directly through EUR.
• Bluwhale — Unlock Web3 Wallet Potential with AI Insights. Supercharge Your Business Growth

Portfolio highlights

• Mytra — Supercharged Industrial Productivity with Bots, Software, and Cells
• Tokemak — Automated DeFi Yield Farming & Liquidity Management
• Hubble Network — Connect a Bluetooth device to a global satellite network, delivering affordable, low-power tracking and monitoring for diverse industrial and commercial applications.

Portfolio highlights

• Hyperion — Join the Hyperion waitlist today to access the only bank account your business will ever need.

Portfolio highlights

• Kestra Technologies — Use declarative language to build simpler, faster, scalable and flexible workflows
• Hyperion — Join the Hyperion waitlist today to access the only bank account your business will ever need.

Portfolio highlights

• OpenAssets — OpenAssets builds open infrastructure and technology for digital financial systems and tokenized capital markets. The company develops standards and platforms for issuing and managing tokenized assets, digital currencies, and programmable money across major blockchains. Its solutions include tokenization-as-a-service, compliant asset issuancetools, and programmable ownership features for bonds, equities, commodities, and other assets. OpenAssets serves governments, central banks, financial institutions, and digital asset companies seeking to modernize capital markets. The organization also convenes industry alliances to define technical, policy, and governance frameworks for programmable finance.
• Superscrypt — Superscrypt is a blockchain investment firm.
• SpaceComputer — SpaceComputer uses satellites to create a secure blockchain system that resists cyberattacks and physical tampering.

Portfolio highlights

• Digs — Digs is an easy-to-use collaboration software solution for professionals in residential home building that provides more efficient file storage, collaboration, and homeowner handoff for home construction projects. Try Digs for free today!
• Shoutcast Net — Audio And Video Live Streaming Platform For Artists, DJs, Singers, Concerts, Events, Conferences.
• Midsummer Studios — Midsummer Studios is a independent, well-funded and committed to building a new kind of studio.

Portfolio highlights

• Tea — Learn more about the tea protocol and how to unlock the rewards for previous and future open-source software contributions.

Portfolio highlights

• Rails — Experience unparalleled speed and efficiency with Rails, your go-to platform for lightning-fast crypto perpetuals trading.
• CWX — CWX is a full-service enterprise cloud consulting company.
• Lightworks — Lightworks is a Canadian consulting company that focuses on enterprise AI infrastructure and control systems. The company works with the biggest and most regulated companies in the world to plan, manage, and safeguard AI-powered systems.

Portfolio highlights

• Tea — Learn more about the tea protocol and how to unlock the rewards for previous and future open-source software contributions.
• Casper Labs — Casper Labs powers scalable, secure & decentralized blockchain solutions for businesses, with the most flexible and customizable architecture on the market

Portfolio highlights

• Axal — Earn competitive returns on your crypto with institutional-grade DeFi strategies, non-custodial security, and seamless user experience.
• Hemi Labs — Hemi (https://hemi.xyz) is a modular protocol that integrates Bitcoin and Ethereum to amplify and extend the core capabilities of the two leading blockchain networks. This offers a novel perspective on blockchain interoperability and scaling by approaching Bitcoin and Ethereum as components of a single supernetwork. The result providessecurity that exceeds that of Bitcoin (“superfinality”) and new levels of blockchain programmability, portability, and potential. Hemi was co-founded by Jeff Garzik (former Bitcoin core developer) and Max Sanchez (inventor of the Proof-of-Proof consensus protocol), and is surrounded by a team of renowned blockchain engineers, strategic partners and investors.
• Movement Labs — Movement Labs is on a mission to create a global community of Move Builders, working together to improve decentralized network user experience.

Portfolio highlights

• CB International Bank — CBiBank is a U.S. commercial bank with a U.S. banking license,Committed to providing one-stop global financial solutions for export companies, import companies, cross-border e-commerce, overseas companies and individual investor users, including overseas bank account opening, cross-border remittance, cross-border payment, global trade collection, etc., Offshore bank account opening is efficient and fast, international remittances are safe, and bilingual and cross-time zone online services are supported.

Portfolio highlights

• Exocore — Exocore is the layer one blockchain for aggregated security.
• Exabits AI — Exabits' network of GPUs ranges from consumer-grade to H100s, offering the most cost-effective compute because we are obsessed with innovating performance.

Portfolio highlights

• IMUA — IMUA is a Layer 1 blockchain that provides shared security by combining decentralized security from well-known blockchains.
• PUML Better Health — Earn cryptocurrency and get rewarded for completing gamified physical and mental health challenges. Available on both Play Store and App Store.

Portfolio highlights

• Truffle Suite — Truffle Suite provides world class development environment for blockchain dapps.
• Shodai Network — Shodai Network mission is to create one that provides long-term conviction and aligned incentives.
• Ceramic Network — Ceramic Network is a provider of protocols for decentralized and composable data applications. The network decentralizes application databases, making data universally composable and reusable across applications. It consists of three core parts: a highly-scalable, decentralized infrastructure for data availability and consensus, a marketplace ofcommunity-created data models, and a suite of standard APIs for storing, updating, and retrieving data from those models.

Portfolio highlights

• Quibble — Price Optimization and Revenue Management Software and Consulting For Vacation Rentals & Alternative Accommodations - We created Quibble to address the gap in the market between the simple rules-based software applications currently available and a truly science-based optimization. Quibble bundles our software with a full service offering togive our clients complete Pricing Ease of Mind. With many years of revenue management experience in the travel and hospitality industries, we know the pains and uncertainty revenue management brings. At Quibble, we aim to increase your revenue performance by engineering and implementing your custom pricing strategy while developing long-lasting partnerships.
• ClassCalc — Students can use their smartphones instead of using or buying a TI calculator, and teachers can ensure they only use the ClassCalc calculator app in class. We believe students and teachers should have a choice other than the same expensive, difficult to learn and use dedicated-purpose TI calculator they have been forced to use for decades.ClassCalc provides a multi-subject math calculator with scientific, graphing, and matrix functionality in an easy-to-use smartphone app. Teachers are able to lock down the student’s phone to only the ClassCalc app for class time, quizzes, tests… no cheating or outside distractions (social media, texting etc).
• Turno, formerly TurnoverBnB — Find now a local Airbnb cleaning service; automatically schedule your existing cleaners. Integrated with all reservations platforms and channel managers.

Portfolio highlights

• Nada — Finance, Invest and Bank your real estate.
• DigiBuild — Automate your construction supply chain with AI.
• Upright — Meet Upright, the good for you go-to. Our first product is a category-defining high-protein, allergen-free Instant Oatmilk in three creamy, delicious flavors: original, vanilla, and chocolate. Each tasty cup of our oatmilk packs the same key nutrients as dairy, without the unwanted allergens or environmental impact.

Portfolio highlights

• Tea — Learn more about the tea protocol and how to unlock the rewards for previous and future open-source software contributions.

Portfolio highlights

• Betty — Betty is a mobile gaming entertainment company that develops the intersection of casual mobile gaming and real money online casinos.
• Manifest — Manifest is an anchor for a generation seeking direction.
• Epic Padel — EPIC is a premier padel sports management and investment company based in Arlington, VA, focused on becoming the leading operator of padel clubs across North America.

Portfolio highlights

• DataRoot — DataRoot provides data science and AI solutions, helping businesses leverage data for growth and optimization.
• Conectamos — Ship with local carriers, more affordable and reliable
• Frente — Nossa missão é transformar a forma com a qual as pessoas fazem câmbio. Unimos a experiência de profissionais com carreira consolidada no mercado financeiro a uma visão inovadora e contemporânea de negócios. Tudo com a potência que a tecnologia de dados trouxe para o universo Fintech.Somos a sua parceira de câmbio mais sólida e confiável, capaz deatender às suas demandas, superando desafios cada vez maiores e mais rápidos, em um mundo em constante transformação. Nossa preocupação verdadeira com um atendimento próximo, consultivo e atencioso, além de taxas acessíveis e preços justos, complementam a experiência que oferecemos. Tudo de forma a trabalharmos para diminuir a carga burocrática e processos engessados das grandes instituições financeiras.