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Top 50 Machine Learning Startup Investors in United States (June 2026)

The most active venture capital funds and angel investors investing in United States Machine Learning startups. This investor list is updated monthly from the Shizune investor database, ranked by number of investments in United States Machine Learning startup companies. Find investors to raise a Seed, Series A or Series B round with Shizune.
Investor Relevant Deals Geography Stage Focus Round Size
Alumni Ventures
VC Fund
81 United States, United Kingdom, Canada Seed, Series A, Series B Software, Artificial Intelligence, Information Technology $1.4M–$86M
Andreessen Horowitz
VC Fund
42 United States, United Kingdom, Brazil Series A, Seed, Series B Software, Information Technology, Artificial Intelligence $1.5M–$105M
SV Aangel
VC Fund
38 United States, Canada, United Kingdom Seed, Series A, Series B Software, Artificial Intelligence, Internet $1M–$107M
Khosla Ventures
VC Fund
36 United States, India, United Kingdom Series A, Series B, Seed Software, Artificial Intelligence, Health Care $2M–$100M
Right Side Capital Management
VC Fund
35 United States, Canada, United Kingdom Seed, Pre-Seed, Convertible Note Software, SaaS, Health Care $18k–$2M
Accel
VC Fund
34 United States, India, United Kingdom Series A, Series B, Seed Software, SaaS, Information Technology $1.5M–$70M
DCVC
VC Fund
33 United States, Canada, United Kingdom Seed, Series A, Series B Software, Artificial Intelligence, Machine Learning $1.5M–$130M
AME Cloud Ventures
VC Fund
33 United States, China, Canada Series A, Seed, Series B Software, Artificial Intelligence, Health Care $1.1M–$75M
Bloomberg Beta
VC Fund
32 United States, Canada, Israel Seed, Series A, Series B Software, Artificial Intelligence, Information Technology $1M–$80M
Greycroft
VC Fund
32 United States, United Kingdom, Germany Series A, Seed, Series B Software, Artificial Intelligence, E-Commerce $1.5M–$75M
Madrona
VC Fund
32 United States, Canada, Spain Series A, Series B, Seed Software, Artificial Intelligence, SaaS $1.5M–$65M
New Enterprise Associates
VC Fund
30 United States, India, United Kingdom Series A, Series B, Series C Software, Health Care, Biotechnology $5.3M–$103M
Hyperplane
VC Fund
30 United States, Canada, Israel Seed, Series A, Series B Software, Artificial Intelligence, Machine Learning $1.5M–$54M
First Round Capital
VC Fund
30 United States, Canada, India Seed, Series A, Series B Software, Information Technology, Artificial Intelligence $1.1M–$60M
General Catalyst
VC Fund
29 United States, United Kingdom, India Series A, Seed, Series B Software, Artificial Intelligence, Health Care $1.5M–$140M
Intel Capital
VC Fund
29 United States, Israel, China Series B, Series A, Series C Software, Information Technology, Enterprise Software $4M–$70M
Sierra Ventures
VC Fund
28 United States, China, Canada Series A, Seed, Series B Software, Information Technology, Artificial Intelligence $2M–$38M
Lux Capital
VC Fund
26 United States, United Kingdom, Canada Series A, Seed, Series B Software, Artificial Intelligence, Health Care $1.8M–$150M
Morado Ventures
VC Fund
26 United States, United Kingdom Seed, Series A, Series B Software, Artificial Intelligence, Enterprise Software $937k–$38M
Lightspeed Venture Partners
VC Fund
25 United States, India, Israel Series A, Series B, Seed Software, Information Technology, Artificial Intelligence $2M–$120M
Gradient
VC Fund
25 United States, Canada, Germany Seed, Series A, Series B Software, Artificial Intelligence, Information Technology $2.5M–$68M
Uncork Capital
VC Fund
25 United States, Canada, Israel Seed, Series A, Series B Software, SaaS, Analytics $1.2M–$50M
Bain Capital Ventures
VC Fund
25 United States, United Kingdom, Canada Series A, Series B, Seed Software, Information Technology, FinTech $2M–$62M
BootstrapLabs
VC Fund
24 United States, Estonia, Malaysia Seed, Series A, Pre-Seed Artificial Intelligence, Machine Learning, Software $300k–$20M
Sequoia Capital
VC Fund
24 United States, China, India Series A, Series B, Series C Software, Information Technology, Artificial Intelligence $5.4M–$180M
Homebrew
VC Fund
24 United States, Mexico, Brazil Seed, Series A, Series B Software, Artificial Intelligence, Information Technology $1.6M–$56M
Zetta Venture Partners
VC Fund
24 United States, The Netherlands, United Kingdom Seed, Series A, Series B Software, Artificial Intelligence, Machine Learning $1.5M–$40M
Amplify Partners
VC Fund
24 United States, Canada, Israel Series A, Seed, Series B Software, Information Technology, Artificial Intelligence $1.6M–$87M
Two Sigma Ventures
VC Fund
24 United States, Canada, Mexico Series A, Series B, Seed Software, Artificial Intelligence, Machine Learning $2M–$70M
Founders Fund
VC Fund
23 United States, United Kingdom, Germany Series A, Seed, Series B Software, Health Care, Information Technology $1.5M–$105M
8VC
VC Fund
23 United States, United Kingdom, Canada Series A, Seed, Series B Software, Health Care, Artificial Intelligence $2.7M–$175M
Kleiner Perkins
VC Fund
23 United States, China, United Kingdom Series B, Series A, Series C Software, Information Technology, Health Care $5M–$100M
Streamlined
VC Fund
23 United States, Mexico, Colombia Seed, Series A Software, Artificial Intelligence, Information Technology $1.5M–$23M
Liquid 2 Ventures
VC Fund
22 United States, Mexico, Canada Seed, Series A, Pre-Seed Software, Artificial Intelligence, Information Technology $1M–$56M
Ulu Ventures
VC Fund
22 United States, Mexico, Nigeria Seed, Series A Software, Financial Services, FinTech $1M–$25M
Google Ventures
VC Fund
22 United States, United Kingdom, Israel Series A, Series B, Seed Software, Health Care, Biotechnology $1M–$105M
M12 - Microsoft's Venture Fund
VC Fund
21 United States, Israel, United Kingdom Series A, Series B, Series C Software, Artificial Intelligence, Machine Learning $7.8M–$100M
SignalFire
VC Fund
21 United States, Israel, Germany Series A, Seed, Series B Software, Artificial Intelligence, Information Technology $2.2M–$75M
BoxGroup
VC Fund
21 United States, Mexico, Canada Seed, Series A, Series B Software, Health Care, Artificial Intelligence $1.5M–$80M
TSVC
VC Fund
21 United States, China, Canada Seed, Series A Software, Artificial Intelligence, Health Care $500k–$27M
Emergent Ventures
VC Fund
20 United States, India, Canada Seed, Series A, Pre-Seed Software, Artificial Intelligence, Information Technology $900k–$32M
Social Starts
VC Fund
20 United States, Germany, United Kingdom Seed, Series A Software, Health Care, Artificial Intelligence $100k–$15M
Felicis
VC Fund
20 United States, Canada, Germany Series A, Seed, Series B Software, Artificial Intelligence, SaaS $1.5M–$79M
Costanoa Ventures
VC Fund
20 United States, Brazil, Egypt Seed, Series A, Series B Software, Artificial Intelligence, Information Technology $2.5M–$60M
Foundation Capital
VC Fund
20 United States, United Kingdom, Canada Seed, Series A, Series B Software, Information Technology, Artificial Intelligence $1.5M–$50M
Matrix
VC Fund
20 United States, China, India Series B, Series A, Series C Software, Artificial Intelligence, Information Technology $4.9M–$100M
Cultivation Capital
VC Fund
19 United States, Australia, Israel Seed, Series A Software, SaaS, Health Care
RRE Ventures
VC Fund
19 United States, Canada, United Kingdom Series A, Seed, Series B Software, Financial Services, Internet $1.1M–$32M
1984 Ventures
VC Fund
19 United States, Mexico, Egypt Seed, Series A, Pre-Seed Software, Health Care, Artificial Intelligence
Flying Fish Partners
VC Fund
19 United States, Canada, United Kingdom Seed, Series A Software, Artificial Intelligence, Machine Learning
Access all 7891 investors in United States Machine Learning startups.

Access 48,091 investors

822 industries, 177 countries. Updated daily. Emails and phones included.

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Investor list

Alumni Ventures
VC Fund · Manchester, New Hampshire, United States · 81 investments in United States Machine Learning startups

Access curated startup investment opportunities and diversified venture capital exposure designed for accredited investors.

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Investment focus

  • Industry: Software, Artificial Intelligence, Information Technology
  • Stage:Seed, Series A, Series B
  • Geography: United States, United Kingdom, Canada

Investor stats

  • Total investments: 1378
  • Round size: Seed $1.4M–$10M; Series A $5M–$37M; Series B $12M–$86M
  • Lead/follow: 15% lead, 85% follow
  • Last fund: Likely actively investing — fund raised in 2025

Portfolio highlights

  • Humio — Humio operates as a time-series logging and aggregation platform designed for unrestricted and comprehensive event analysis. It is deployable on any infrastructure including both in the cloud and on-premises. Humio enables data aggregation, exploration, reporting, and analysis from a range of sources ingesting massive volumes of log data instantly.Its data storage and in-memory search/query engine technologies provide customers cost-competitive log management and analysis solution, all while requiring significantly less hardware and engineering resources.The company was founded in 2016 and is headquartered in London, England.
  • OpusClip — Opus Clip turns long videos into high-quality viral clips for you to share on TikTok, YouTube Shorts, and Reels to increase social media reach.
  • Arda Therapeutics — Arda Therapeutics is a biotechnology company taking aim at chronic diseases and aging by eliminating the pathogenic cells that drive these conditions. Their approach starts by using single-cell data to identify pathogenic cells and specific markers to target them. They then design therapies to eliminate these - and only these - cells.Arda wasfounded in 2021 in the San Francisco Bay Area, CA.
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Andreessen Horowitz
VC Fund · Menlo Park, California, United States · 42 investments in United States Machine Learning startups

Andreessen Horowitz (a16z) is a venture capital firm in Silicon Valley, California, investing in bold founders, innovators, and entrepreneurs building the future through technology.

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Investment focus

  • Industry: Software, Information Technology, Artificial Intelligence
  • Stage:Series A, Seed, Series B
  • Geography: United States, United Kingdom, Brazil

Investor stats

  • Total investments: 1578
  • Round size: Seed $1.5M–$15M; Series A $8.8M–$52M; Series B $16M–$105M
  • Lead/follow: 47% lead, 53% follow
  • Last fund: Likely actively investing — fund raised in 2025

Portfolio highlights

  • Julep — We are Julep, creators of innovative makeup, skincare, nail polish & sets. Every day is a chance to Brave Pretty.
  • Shapeways — Shapeways is the #1 online 3D printing service company. Working with over a million customers since 2007 - Get 3D products and parts delivered to over 100 countries.
  • Adaptive Security — Adaptive's next-generation security training and simulations protect businesses from deepfakes, generative AI phishing, SMS attacks, voice phishing, and more emerging threats.
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SV Aangel
VC Fund · San Francisco, California, United States · 38 investments in United States Machine Learning startups

SV Angel is a service organization, investing in founders who share these values. They support entrepreneurs in building lasting companies by assisting at key inflection points and leveraging networks to help them propel their businesses forward.

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Investment focus

  • Industry: Software, Artificial Intelligence, Internet
  • Stage:Seed, Series A, Series B
  • Geography: United States, Canada, United Kingdom

Investor stats

  • Total investments: 923
  • Round size: Seed $1M–$9.2M; Series A $2.5M–$35M; Series B $8M–$107M
  • Lead/follow: 2% lead, 98% follow
  • Last fund: Likely still investing — raised $29M in 2022

Portfolio highlights

  • Terra Industries — Terra Industries develops autonomous security systems and software platforms that support the monitoring and protection of physical assets, infrastructure, and operational environments across land, air, and maritime domains. The company provides unmanned vehicles, autonomous towers, and sensor-based surveillance hardware that collect and transmitdata for continuous situational awareness. Its software layer, built around an integrated operating system, processes sensor inputs, applies artificial intelligence models, and coordinates automated responses to detected events. Terra Industries designs its systems to support functions such as perimeter security, infrastructure monitoring, asset tracking, and threat detection within complex operational settings. The company’s platforms enable operators to manage multiple autonomous devices through a unified interface that supports mission planning, data visualization, and system control. Its technology is used by organizations that require coordinated security, monitoring, and response capabilities for facilities, remote sites, and distributed operations.
  • Periodic Labs — Periodic Labs develops artificial intelligence systems that simulate and predict the properties of materials using machine learning. The company applies computational models to support the discovery and design of materials used in sectors such as energy, electronics, and infrastructure. It builds tools that aim to reduce the time and costassociated with traditional research and development processes. Periodic Labs uses AI to analyze large-scale scientific data and collaborates with academic and industry partners to support material science research.
  • depthfirst — An AI-native security platform that understands your code, business logic, and infrastructure to find more vulnerabilities, slash false positives, and give developers actionable fixes in their workflow.
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Khosla Ventures
VC Fund · Menlo Park, California, United States · 36 investments in United States Machine Learning startups

Khosla Ventures is a venture capital firm that invests in early- to late-stage companies across sectors like AI, healthcare, sustainability, and consumer technology. It manages multiple funds, focusing on startups with innovative technologies or business models. The firm primarily targets sectors like AI, climate tech, digital health, and medtech,offering strategic support to help build long-lasting companies.

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Investment focus

  • Industry: Software, Artificial Intelligence, Health Care
  • Stage:Series A, Series B, Seed
  • Geography: United States, India, United Kingdom

Investor stats

  • Total investments: 1050
  • Round size: Seed $2M–$15M; Series A $5.5M–$40M; Series B $10M–$100M
  • Lead/follow: 40% lead, 60% follow
  • Last fund: Likely still investing — raised $557M in 2022

Portfolio highlights

  • Hunch — Hunch is a consumer web application that is building the "taste graph" of the internet, mapping every person on the internet to every entity on the internet and their affinity for that entity. An entity could be a web site, a cookbook, a hotel room, a celebrity, a restaurant, etc.Hunch creates a taste profile by asking them a seriesof questions which range from serious to profound and subsequently can make recommendations personalized to that user, which live in "topics".Topics vary widely, from entertaining subjects like 'Which superhero would you be' to more conventional questions like 'Should I Switch to A Mac?' The system then uses the answers to these questions to offer the user a suggested solution, a "hunch" of what the user would like.
  • Speak — People spend $90 billion a year on human english teachers that are expensive and ineffective. Speak offers a mobile app where you can have english conversations with your phone about real world scenarios like interviewing for a job or asking for directions. It uses speech recognition to identify english words through thick accents and teach peopleto speak more clearly. Meanwhile, it’s building a massive database of accented-english speech, which can be used to improve its system and other speech recognition systems. Speak’s team formerly built accent detection systems and sold Flashcards+ to Chegg. Though AI translation might reduce the need for people to know other languages, speaking English remains a valuable skill people are willing to pay for.
  • The Climate Corporation (Bayer Crop Science) — The Climate Corporation (formerly WeatherBill) aims to help farmers around the world protect and improve their farming operations with uniquely powerful software, hardware and insurance products. The company’s proprietary Climate Technology Platform combines hyper-local weather monitoring, agronomic modeling, and high-resolution weather simulationsto deliver Climate Basic and Climate Pro, mobile SaaS solutions that helps farmers improve profitability by making better informed operating and financing decisions.
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Right Side Capital Management
VC Fund · San Francisco, California, United States · 35 investments in United States Machine Learning startups

Systematic Pre-Seed Startup Capital

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Investment focus

  • Industry: Software, SaaS, Health Care
  • Stage:Seed, Pre-Seed, Convertible Note
  • Geography: United States, Canada, United Kingdom

Investor stats

  • Total investments: 648
  • Round size: Seed $18k–$2M; Pre-Seed $35k–$450k; Convertible Note $50k–$500k
  • Lead/follow: 4% lead, 96% follow
  • Last fund: Likely actively investing — fund raised in 2025

Portfolio highlights

  • Cohley — Cohley is a content marketing platform focusing on user generated content, visual asset creation, and text review generation. Streamline your content generation today!
  • Shipsi — Shipsi empowers any retailer with the ability to offer an easy “instant shipping” option on their checkout page—without worrying about logistics. They use existing infrastructure and last-mile delivery networks to help customers order now AND get it now. Shipsi was founded in 2017 and is headquartered in Austin, TX.
  • Ceemo — Ceemo - Ceemo's simple 5-step quiz generates a complete brand & all the foundational marketing assets your small biz needs in just 10 minutes or less.
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Accel
VC Fund · Palo Alto, California, United States · 34 investments in United States Machine Learning startups

First partner to exceptional teams everywhere

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Investment focus

  • Industry: Software, SaaS, Information Technology
  • Stage:Series A, Series B, Seed
  • Geography: United States, India, United Kingdom

Investor stats

  • Total investments: 1836
  • Round size: Seed $1.5M–$10M; Series A $4.4M–$40M; Series B $9.5M–$70M
  • Lead/follow: 43% lead, 57% follow
  • Last fund: May invest from a new fund soon — raised $14M in 2019

Portfolio highlights

  • Solda.AI — Fully automated sales departments for b2c
  • Higgsfield — The ultimate AI-powered camera control for creators by creators
  • Dovetail — Make sense of all kinds of customer research in one intuitive, collaborative, and searchable research repository.
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DCVC
VC Fund · San Francisco, California, United States · 33 investments in United States Machine Learning startups

We are deep tech venture capital.

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Investment focus

  • Industry: Software, Artificial Intelligence, Machine Learning
  • Stage:Seed, Series A, Series B
  • Geography: United States, Canada, United Kingdom

Investor stats

  • Total investments: 381
  • Round size: Seed $1.5M–$10M; Series A $5.7M–$50M; Series B $15M–$130M
  • Lead/follow: 24% lead, 76% follow
  • Last fund: Likely still investing — raised $1B in 2023

Portfolio highlights

  • Twelve — Twelve is a carbon transformation company converting captured carbon dioxide into valuable chemicals, fuels, and other essential products. Their technology eliminates emissions by turning CO2 into essential products that are made from fossil fuels. They specialize in the fields of CO2 electrocatalysis and electrochemical reactor design.
  • ZwitterCo — ZwitterCo is revolutionizing water & wastewater treatment with cutting-edge membrane technology, along with providing sustainable, high-efficiency solutions.
  • Petra — Petra is a robotics company that can bury utilities in the most difficult and disaster-prone areas on earth.
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AME Cloud Ventures
VC Fund · Palo Alto, California, United States · 33 investments in United States Machine Learning startups

AME Cloud Ventures invests in seed to later-stage tech companies that build infrastructure and value chains around data.

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Investment focus

  • Industry: Software, Artificial Intelligence, Health Care
  • Stage:Series A, Seed, Series B
  • Geography: United States, China, Canada

Investor stats

  • Total investments: 253
  • Round size: Seed $1.1M–$10M; Series A $5M–$35M; Series B $14M–$75M
  • Lead/follow: 4% lead, 96% follow

Portfolio highlights

  • Vectra AI — Vectra AI develops an AI-driven integrated attack signal for threat detection and response. It empowers hybrid and multi-cloud enterprises to see and stop advanced attacks before they become breaches. The company assists SOC analysts in turning the tables on attackers by applying artificial intelligence and machine learning to the problem offinding attack signals.
  • Matterport — Our 3D cameras and virtual tour software platform help you digitize your building, automatically create 3D tours, 4K print quality photos, schematic f
  • Ellipsis Health — Harnessing the human voice as a biomarker for mental health and wellbeing, along with machine learning and AI, Ellipsis Health generates a clinical-grade assessment of the severity of anxiety and depression, as well as a sub-clinical assessment of the severity of stress - creating the first vital sign for mental health.
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Bloomberg Beta
VC Fund · San Francisco, California, United States · 32 investments in United States Machine Learning startups

Bloomberg Beta is an early-stage venture capital firm with $450M under management, capitalized solely by Bloomberg. The fund exists to expand Bloomberg’s horizons by investing in companies built by extraordinary founders that make business work better, with a focus on machine intelligence.

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Investment focus

  • Industry: Software, Artificial Intelligence, Information Technology
  • Stage:Seed, Series A, Series B
  • Geography: United States, Canada, Israel

Investor stats

  • Total investments: 284
  • Round size: Seed $1M–$8M; Series A $5M–$24M; Series B $10M–$80M
  • Lead/follow: 14% lead, 86% follow
  • Last fund: Likely actively investing — fund raised in 2025

Portfolio highlights

  • StrongDM — Manage access to any server, database, or Kubernetes instance in minutes. Fully auditable, replayable, secure, and drag-and-drop easy.
  • Enigma — Enigma helps companies find the best cybersecurity talent by offering a unique, puzzle-based platform to evaluate candidates based on real-world skills.
  • Wrangle — Wrangle organizes requests in your Slack team channel. Automatically assign approvals and tasks for your team to follow up and track their status.
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Greycroft
VC Fund · New York, New York, United States · 32 investments in United States Machine Learning startups

Venture capital and technology investments

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Investment focus

  • Industry: Software, Artificial Intelligence, E-Commerce
  • Stage:Series A, Seed, Series B
  • Geography: United States, United Kingdom, Germany

Investor stats

  • Total investments: 693
  • Round size: Seed $1.5M–$8.5M; Series A $3.1M–$23M; Series B $6.2M–$75M
  • Lead/follow: 32% lead, 68% follow
  • Last fund: Likely still investing — raised $378M in 2023

Portfolio highlights

  • Peer AI — The AI platform for life sciences regulatory submissions. Author documents faster, orchestrate programs in real time, and anticipate queries before filing.
  • Guidesly — Find the best fishing charters & fishing guides. Search and book from THOUSANDS of top fishing charters across the United States. Explore trips today
  • Veritonic — Veritonic is a marketing analytics platform that offers online testing and optimization services for firms in the music industry.Veritonic’s product portfolio consist of testing, analytics, and workflow. Testing assists its users in making data-driven decisions, measuring emotional response, and obtaining qualitative and quantitative responses.Analytics assists its users in benchmarking their brand progress. Workflow enables its users to manage, save, and share tracks with others.Veritonic was founded in 2015 by Andrew Eisner and Scott Simonelli.
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Access 48,091 investors

822 industries, 177 countries. Updated daily. Emails and phones included.

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Madrona
VC Fund · Seattle, Washington, United States · 32 investments in United States Machine Learning startups

A venture capital firm that teams with technology entrepreneurs to nurture ideas from startup to market success.

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Investment focus

  • Industry: Software, Artificial Intelligence, SaaS
  • Stage:Series A, Series B, Seed
  • Geography: United States, Canada, Spain

Investor stats

  • Total investments: 464
  • Round size: Seed $1.5M–$13M; Series A $2.7M–$25M; Series B $6M–$65M
  • Lead/follow: 36% lead, 64% follow
  • Last fund: Likely still investing — raised $260M in 2022

Portfolio highlights

  • Spice AI — Designed for apps and machine learning, Spice AI is helping developers working with web3 and blockchain data to build the next generation of apps.
  • Polly — Polly gets answers to your most important questions, instantly. Get in context feedback from your colleagues in Slack, Teams and Zoom.
  • ShopIgniter — Reaching and converting social mobile consumers is now essential for most brands and their agencies. But advertising on social networks is only half the solution. To deliver high-value brand and business outcomes - at scale - marketers need tools and expertise that enable robust targeting, ad creative tuning, mobile landing page testing andintegrated conversion optimization and remarketing. ShopIgniter’s powerful social performance marketing platform enables digital marketing leaders to reach and convert their highest value social mobile consumers. Innovative brands like Target, Ford, Disney, Sony Music, Nike and Universal use the Igniter platform to deliver, manage, optimize and measure highly effective social media advertising campaigns in social streams that drive brand and business outcomes across networks and devices. Founded in 2009 and funded by Madrona Venture Group and Trinity Partners, ShopIgniter is headquartered in Portland, Oregon.More information can be found at www.shopigniter.com.
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New Enterprise Associates
VC Fund · Menlo Park, California, United States · 30 investments in United States Machine Learning startups

Foundational partners to ambitious founders at every stage of company-building.

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Investment focus

  • Industry: Software, Health Care, Biotechnology
  • Stage:Series A, Series B, Series C
  • Geography: United States, India, United Kingdom

Investor stats

  • Total investments: 1525
  • Round size: Series A $5.3M–$60M; Series B $10M–$80M; Series C $13M–$103M
  • Lead/follow: 40% lead, 60% follow
  • Last fund: Likely still investing — raised $2.8B in 2022

Portfolio highlights

  • AviadoBio — AviadoBio mission is to transform the lives of people living with neurodegenerative disorders by developing and delivering transformative gene therapies for diseases including frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The Company’s technology is based on pioneering research from King’s College London and the UK DementiaResearch Institute.
  • Tarveda Therapeutics — Developing Pentarins to make a difference in the treatment of patients with solid tumor malignancies
  • InfoGear Technology — InfoGear produces software and ASICs for the low-cost Internet Appliance market. The initial product, iPHONE, is a smart telephone with a touch screen for simple access to on-line services and the Internet/Intranet. The company was founded in 1995 and is based in Redwood City, California.
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Hyperplane
VC Fund · Boston, Massachusetts, United States · 30 investments in United States Machine Learning startups

Hyperplane Venture Capital is an investment firm focused on exceptional founders building machine intelligence and data companies. They partner with exceptional founders who are leveraging machine intelligence, sensor technology, and cloud computing to solve the world’s hardest problems uncovering the underlying structure for each problem andcreating solutions at the nexus of perception, communication, intelligence, and insight.The company was founded by Vivjan Myrto, John Murphy and Brendan Kohler in 2015; and is headquartered in Boston, Massachusetts.

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Investment focus

  • Industry: Software, Artificial Intelligence, Machine Learning
  • Stage:Seed, Series A, Series B
  • Geography: United States, Canada, Israel

Investor stats

  • Total investments: 105
  • Round size: Seed $1.5M–$6.7M; Series A $5.6M–$24M; Series B $15M–$54M
  • Lead/follow: 30% lead, 70% follow

Portfolio highlights

  • Aryeo — Aryeo is building the future of real estate content. The visual representation of a home is more important than ever, with homebuyers now expecting images, videos, 3D tours, and floor plans on every listing. Aryeo’s platform provides photographers, agents, and brokerages with a centralized content system enabling consistent data feeds, marketingautomation, and streamlined workflows. The platform is used to host hundreds of thousands of properties every year and has a presence in all 50 US states, as well as Canada and Australia.
  • Senpilot — The ultimate artificial intelligence (AI) system built specifically for Utilities. Plug into current GIS, DERMS, SCADA systems and utilize new AI capabilities!
  • LinkSquares — Businesses rely on LinkSquares to easily draft, review, and execute agreements with an AI-powered contract management platform.
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First Round Capital
VC Fund · San Francisco, California, United States · 30 investments in United States Machine Learning startups

First Round is a seed-stage venture firm focused on building a vibrant community of technology entrepreneurs and companies.

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Investment focus

  • Industry: Software, Information Technology, Artificial Intelligence
  • Stage:Seed, Series A, Series B
  • Geography: United States, Canada, India

Investor stats

  • Total investments: 796
  • Round size: Seed $1.1M–$8.4M; Series A $2.1M–$25M; Series B $7M–$60M
  • Lead/follow: 24% lead, 76% follow

Portfolio highlights

  • Diversio — Transform workplace culture with AI-powered DEI analytics, expert-led training workshops, and strategic consulting. Trusted by Amazon, Honda, Canadian Blood Services, Danone, and leading organizations.
  • Rupa Health — Rupa Health is a telehealth solution that makes it easier to practice root cause medicine. The company was established in 2018 and was founded by Tara Viswanathan in San Francisco, California.
  • Spreadsheet.com — The spreadsheet you know with the power of a database and project management system. Gantt, Kanban, Forms, and Automations. Get started free.
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General Catalyst
VC Fund · Cambridge, Massachusetts, United States · 29 investments in United States Machine Learning startups

Investing in powerful, positive change that endures

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Investment focus

  • Industry: Software, Artificial Intelligence, Health Care
  • Stage:Series A, Seed, Series B
  • Geography: United States, United Kingdom, India

Investor stats

  • Total investments: 1421
  • Round size: Seed $1.5M–$15M; Series A $5.5M–$60M; Series B $12M–$140M
  • Lead/follow: 45% lead, 55% follow
  • Last fund: Likely actively investing — fund raised in 2024

Portfolio highlights

  • Endo Health — Reverse Your Diabetes With a Game
  • Contrast Security — Contrast Security application security software unifies security and development with one DevSecOps platform and increases accuracy and productivity.
  • Fulcrum Technologies — Fulcrum Technologies is a software company that offers software for asset management. Fulcrum develops software for Asset Lifecycle Management, Warehouse Management, GIS Tracking, Document Management, Regulatory Compliance, and many other areas.
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Intel Capital
VC Fund · Santa Clara, California, United States · 29 investments in United States Machine Learning startups

Intel Capital invests in innovative startups targeting cloud and AI infrastructure, edge, 5G, autonomy, cybersecurity, client & gaming, enterprise applications, silicon design and manufacturing, and a wide range of other disruptive technologies.

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Investment focus

  • Industry: Software, Information Technology, Enterprise Software
  • Stage:Series B, Series A, Series C
  • Geography: United States, Israel, China

Investor stats

  • Total investments: 935
  • Round size: Series A $4M–$30M; Series B $7M–$50M; Series C $7M–$70M
  • Lead/follow: 34% lead, 66% follow

Portfolio highlights

  • KupiVIP — KupiVIP is a Russian online fashion retailer selling discounted fashion and home goods from high-street and luxury brands. It has grown rapidly to become a household name in Russia, with 6 million customers. The online fashion retailer hosts up to 20 private online flash sales every day.KupiVIP was launched in 2008 by Vladimir Kholyaznikov,Mikhail Konoplev, and Oskar Hartmann. It is based in Moscow, Russia.
  • Polystream — Polystream is completely rethinking and realising new ways of how to use the visual cloud, from server to client, from network to edge as we build the 3D Internet. Powered by our breakthrough command streaming technology, you can now instantly engage, grow, and monetise audiences of all shapes and sizes wherever they are in the world; whether it’splayers, streamers, or viewers. Our synchronous spectator engine Fantom enables cloud native games and experiences to be cost-effectively streamed with unrivalled reach, and unprecedented scale.
  • 3d Glass Solutions — 3DGS manufactures glass substrates for advanced packaging to solve the thermal, electrical, and dimensional challenges of next-generation RF, HPC, and photonic systems.
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Sierra Ventures
VC Fund · San Mateo, California, United States · 28 investments in United States Machine Learning startups

Sierra Ventures is an early-stage venture capital firm investing in the future of enterprise, healthcare, infrastructure, and more.

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Investment focus

  • Industry: Software, Information Technology, Artificial Intelligence
  • Stage:Series A, Seed, Series B
  • Geography: United States, China, Canada

Investor stats

  • Total investments: 331
  • Round size: Seed $2M–$11M; Series A $4.3M–$20M; Series B $5.7M–$38M
  • Lead/follow: 30% lead, 70% follow
  • Last fund: May invest from a new fund soon — raised $79M in 1991

Portfolio highlights

  • SenSage — IgniteTech provides an innovative home for the software solutions our customers rely on.
  • TeamOhana — TeamOhana unifies people, processes, and data into one single source of truth so you can execute your headcount plan on time and within budget.
  • SupportLogic — SupportLogic extracts customer sentiment signals so you can predict and prevent escalations, reduce churn, and protect and grow revenue.
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Lux Capital
VC Fund · New York, New York, United States · 26 investments in United States Machine Learning startups

Lux Capital manages over $5 billion in assets focused on founding, seed, early-stage, and growth investments at the intersection of technology and the sciences. Lux takes an active role in helping entrepreneurs build successful businesses in high-growth sectors. Its investment team has built over 20 companies from scratch. Lux's investmentstrategy ensures portfolio companies are better connected, have a deeper insight, and command industry leadership faster than their competitors.

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Investment focus

  • Industry: Software, Artificial Intelligence, Health Care
  • Stage:Series A, Seed, Series B
  • Geography: United States, United Kingdom, Canada

Investor stats

  • Total investments: 497
  • Round size: Seed $1.8M–$30M; Series A $7M–$60M; Series B $13M–$150M
  • Lead/follow: 31% lead, 69% follow
  • Last fund: May invest from a new fund soon — raised $100M in 2007

Portfolio highlights

  • Arraiy — Headquartered in Palo Alto, Arraiy is building the premier AI-driven production platform for the motion picture and television industry. Arraiy is collaborating with major studios, industry veterans, and award-winning artists to re-invent the filmmaking process with machine learning at its foundation. With its products, Arraiy seeks to enhance thecreative freedom of storytellers and unlock the next generation of visual storytelling.
  • Clarifai — Clarifai is the leading Machine Learning, Computer Vision, NLP Platform. Label, train, deploy models on one AI platform for developers & data scientists.
  • Primer — Primer makes powerful mission-ready AI software designed to work in your environment, on your data. We help national security teams sift through massive unstructured data sets to find the needle in the haystack, understand and visualize their data, and act collaboratively. Our mission is to empower decisions that can be defended, and acted upon confidently.
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Morado Ventures
VC Fund · Palo Alto, California, United States · 26 investments in United States Machine Learning startups

A tech-forward seed fund backing exceptional founders building the next generation of transformative companies

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Investment focus

  • Industry: Software, Artificial Intelligence, Enterprise Software
  • Stage:Seed, Series A, Series B
  • Geography: United States, United Kingdom

Investor stats

  • Total investments: 178
  • Round size: Seed $937k–$8M; Series A $3M–$19M; Series B $8M–$38M
  • Lead/follow: 10% lead, 90% follow
  • Last fund: Likely still investing — fund raised in 2023

Portfolio highlights

  • Scribe — By capturing your process while you work, Scribe automatically generates a visual guide, ready to share with the click of a button.
  • one.bio — BCD Bioscience is an emerging biotechnology spinout from UC Davis that creates ingredients for food and biopharmaceutical applications. The company was founded in 2019 and is headquartered in Davis, California, United States.
  • Quill Meetings — Quill captures every meeting insight, action item, and decision so your team can focus on what matters most.
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Lightspeed Venture Partners
VC Fund · Menlo Park, California, United States · 25 investments in United States Machine Learning startups

Lightspeed Venture Partners is a multi-stage venture capital firm focused on accelerating disruptive innovations and trends.

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Investment focus

  • Industry: Software, Information Technology, Artificial Intelligence
  • Stage:Series A, Series B, Seed
  • Geography: United States, India, Israel

Investor stats

  • Total investments: 1348
  • Round size: Seed $2M–$25M; Series A $6M–$80M; Series B $12M–$120M
  • Lead/follow: 40% lead, 60% follow
  • Last fund: Likely still investing — raised $2.4B in 2022

Portfolio highlights

  • Seel — Peace of mind for shoppers and increased conversion rate for merchants. Available on Shopify App Store.
  • Alchemy — Whether you're a beginner, working on a side project, or one of the largest teams in the blockchain space, Alchemy makes Ethereum development easy with enhanced APIs, node infrastructure, and developer tooling. Get started for free!
  • Scrut Automation — Scrut Automation makes ISO 27001, SOC 2, GDPR and PCI DSS compliance easy, with 70% less Manual effort
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Gradient
VC Fund · Mountain View, California, United States · 25 investments in United States Machine Learning startups

Gradient is a seed fund that focuses on supporting founders in the artificial intelligence sector. The firm collaborates closely with innovators to integrate AI into various business processes and drive technological advancements. Gradient aims to foster disruptive ideas that can redefine industries and enhance operational capabilities.

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Investment focus

  • Industry: Software, Artificial Intelligence, Information Technology
  • Stage:Seed, Series A, Series B
  • Geography: United States, Canada, Germany

Investor stats

  • Total investments: 284
  • Round size: Seed $2.5M–$8.8M; Series A $8.3M–$27M; Series B $23M–$68M
  • Lead/follow: 52% lead, 48% follow

Portfolio highlights

  • PopSQL — PopSQL is a developer of collaborative SQL query editing software designed to share queries and visualize data. The company's software stores SQL queries and runs regularly, grouping them into folders that can be kept private or shared among the team, track changes so it can be reverted if or when something breaks, enabling users to workcollaboratively on queries and then distribute among the team.
  • RevOps — Close deals faster, with fewer errors, and have full visibility throughout the process.
  • 'nuffsaid — Nuffsaid helps people focus on the work that matters. Our product centralizes your work apps—email, chat, Salesforce, Jira, and more—and uses AI to prioritize the work that will move the needle in your role. We offer a Personal package and Teams upgrade.
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Uncork Capital
VC Fund · San Francisco, California, United States · 25 investments in United States Machine Learning startups

For more than 20 years, Uncork has focused on one stage: seed. Our partners have invested in over 290 companies, with more than 100 meaningful outcomes and $60B+ in enterprise value created — including Fitbit (NYSE: FIT, Google), Sendgrid (NYSE: SEND, Twilio), Eventbrite (NYSE: EB), Poshmark (NASD: POSH), and Postmates (UBER), as well asfast-growing startups like We invest in companies using AI and emerging technologies to create leverage, unlock scale, and push industries forward. We're typically the first major check on the cap table, often leading seed rounds with an initial investment of $3M-$5M. We keep terms simple and transparent, because a clean term sheet makes a strong partnership.We look for team, TAM, and tailwinds, but conviction in founder–market fit comes above all else. We back founders who bring sharp insight into their markets and the drive to build what others can’t yet see.There’s no single playbook for building a company. Every journey looks different, but our role stays the same: a steady partner who shows up early, knows when to deliver hard truths, and stays engaged long after the round closes.Learn more at

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Investment focus

  • Industry: Software, SaaS, Analytics
  • Stage:Seed, Series A, Series B
  • Geography: United States, Canada, Israel

Investor stats

  • Total investments: 400
  • Round size: Seed $1.2M–$6M; Series A $1.8M–$18M; Series B $10M–$50M
  • Lead/follow: 22% lead, 78% follow
  • Last fund: Likely still investing — fund raised in 2023

Portfolio highlights

  • Wrapbook — Meet the unified platform for film, TV, and commercial production payroll, accounting, and cost-tracking. Wrapbook offers automated timecards, compliance, budget management, and much more.
  • Datapeople — Recruiting analytics helps hiring teams write inclusive job descriptions and measure the effectiveness of their talent funnel.
  • Adentro — Zenreach created Walk-Through Marketing to help businesses with physical locations dramatically improve customer acquisition and lifetime value by connecting digital marketing with in-store results. Zenreach Engage automatically tracks customer visits, effortlessly builds rich customer profiles and keeps them up to date. Zenreach Attract improvesad performance 4x by targeting audiences based on your best customers. Results are measured with our Walk-Through Rate™, a proprietary metric that shows when someone exposed to an ad visits a location. Founded in 2012, Zenreach serves thousands of independent merchants and leading brands like Peet’s Coffee, Ruth’s Chris and BCBG Max Azria.
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Bain Capital Ventures
VC Fund · San Francisco, California, United States · 25 investments in United States Machine Learning startups

Bain Capital Ventures helps founders build iconic businesses that transform the way we live and work.

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Investment focus

  • Industry: Software, Information Technology, FinTech
  • Stage:Series A, Series B, Seed
  • Geography: United States, United Kingdom, Canada

Investor stats

  • Total investments: 688
  • Round size: Seed $2M–$8.1M; Series A $5.3M–$33M; Series B $9.2M–$62M
  • Lead/follow: 45% lead, 55% follow
  • Last fund: May invest from a new fund soon — last raise in 2004

Portfolio highlights

  • Polars — DataFrames for the new era
  • Periodic Labs — Periodic Labs develops artificial intelligence systems that simulate and predict the properties of materials using machine learning. The company applies computational models to support the discovery and design of materials used in sectors such as energy, electronics, and infrastructure. It builds tools that aim to reduce the time and costassociated with traditional research and development processes. Periodic Labs uses AI to analyze large-scale scientific data and collaborates with academic and industry partners to support material science research.
  • Relay — Relay (Relay Financial), is an all-in-one business banking and money management platform helping businesses understand what they're earning, spending & saving.
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BootstrapLabs
VC Fund · San Francisco, California, United States · 24 investments in United States Machine Learning startups

BootstrapLabs is a leading early-stage Venture Capital firm based in San Francisco focused on Applied AI - that was founded by entrepreneurs for entrepreneurs. The firm understands firsthand the needs and challenges of building a startup, and invests early in potentially disruptive Applied AI technology startups with global potential. And isuncovering the future by investing in Applied AI. Key sectors of interest include Transportation, Logistic, Energy, FinTech, Future of Work (FoW), Security, Internet of Things (IoT), HealthTech, and others.

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Investment focus

  • Industry: Artificial Intelligence, Machine Learning, Software
  • Stage:Seed, Series A, Pre-Seed
  • Geography: United States, Estonia, Malaysia

Investor stats

  • Total investments: 58
  • Round size: Seed $300k–$5M; Pre-Seed $2M–$2.6M; Series A $1.5M–$20M
  • Lead/follow: 38% lead, 62% follow
  • Last fund: May invest from a new fund soon — last raise in 2018

Portfolio highlights

  • Pryon — Pryon is the leading AI-as-a-Service platform for content and knowledge management. Pryon closes knowledge gaps, improving employee productivity, and enhancing customer experiences. Companies such as Georgia Pacific use Pryon to improve health and safety outcomes, eliminate compliance incidents, improve employee onboarding, and upgrade all aspectsof customer service and support.
  • Looq AI — Looq AI is an enterprise software company that offers 3D survey and mapping services using artificial intelligence.
  • Charm Solutions — Charm Solutions wants to revolutionise the loan process by harnessing data's potential to give analytics, actionable insights, simplified decisioning, and a dedication to assisting businesses in growing.
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Sequoia Capital
VC Fund · Menlo Park, California, United States · 24 investments in United States Machine Learning startups

We help the daring build We help the daring build legendary companies from idea to IPO and beyond. companies.

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Investment focus

  • Industry: Software, Information Technology, Artificial Intelligence
  • Stage:Series A, Series B, Series C
  • Geography: United States, China, India

Investor stats

  • Total investments: 1594
  • Round size: Series A $5.4M–$40M; Series B $10M–$100M; Series C $10M–$180M
  • Lead/follow: 38% lead, 62% follow
  • Last fund: May invest from a new fund soon — raised $65M in 2018

Portfolio highlights

  • RobCo — Easily automate the repetitive tasks in your production facility with modular industrial robots from RobCo.
  • Rillet — Rillet automates majority of month-end close and offers powerful GAAP and SaaS reporting. The software has built-in revenue recognition, invoicing, and AI-powered accounting.
  • Nevis — Nevis is the world's first AI-powered platform designed specifically for wealth management. It automates operational tasks that consume as much as 80% of a financial advisor's day, such as meeting preparation, document management, opening custodian accounts, and client onboarding. This allows advisors to focus more on deliveringpersonalized client service and growing their businesses.
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Homebrew
VC Fund · San Francisco, California, United States · 24 investments in United States Machine Learning startups, 9 in the past 12 months

Seed venture capital and operational expertise for mission-driven entrepreneurs

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Investment focus

  • Industry: Software, Artificial Intelligence, Information Technology
  • Stage:Seed, Series A, Series B
  • Geography: United States, Mexico, Brazil

Investor stats

  • Total investments: 189
  • Round size: Seed $1.6M–$7.5M; Series A $7.4M–$26M; Series B $18M–$56M
  • Lead/follow: 16% lead, 84% follow
  • Last fund: Likely still investing — fund raised in 2024

Portfolio highlights

  • Archimetis — Archimetis provides an AI-powered operational reasoning system for complex industrial facilities. The platform applies industrial AI and agent-based reasoning to help energy, chemical, pharma, and refinery operators predict failures and optimize processes in real time. Archimetis analyzes plant data from planning to execution to support faster,higher-confidence operational decisions. The system is designed for refineries and process manufacturing environments seeking to reduce downtime and improve throughput. Archimetis also offers demos and implementation support for refinery and process manufacturing teams.
  • Slang — Slang.ai is an AI answering service that's dead simple to set up. It's a better alternative to sending your customers to voicemail and losing business when you can't answer the phone.
  • VillageSQL — VillageSQL is the innovation platform for MySQL and is a drop-in replacement for MySQL with extensions for the agentic AI era.
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Zetta Venture Partners
VC Fund · San Francisco, California, United States · 24 investments in United States Machine Learning startups

Venture Capital for AI Native Startups

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Investment focus

  • Industry: Software, Artificial Intelligence, Machine Learning
  • Stage:Seed, Series A, Series B
  • Geography: United States, The Netherlands, United Kingdom

Investor stats

  • Total investments: 111
  • Round size: Seed $1.5M–$11M; Series A $5M–$20M; Series B $11M–$40M
  • Lead/follow: 39% lead, 61% follow
  • Last fund: May invest from a new fund soon — raised $180M in 2020

Portfolio highlights

  • Clearbit — The Clearbit Data Activation Platform helps B2B teams understand customers, identify prospects, & personalize interactions with real-time intelligence.
  • Tractable — Tractable is a software company that develops artificial intelligence for accident and disaster recovery. Through the use of deep learning to automate visual damage appraisal, Tractable's AI looks at photos of the damage and predicts repair costs. By providing its AI to the largest insurers worldwide, Tractable helps to settle claims quicklyand efficiently, which in turn impacts livelihoods.Tractable AI Review and AI Estimating products help them improve their claims processes and produce live, end-to-end estimates of vehicle damage. Tractable’s pitch is that AI appraisals of damage to vehicles/property can take place via its platform “in minutes”, thereby allowing for repairs to begin sooner and people’s livelihoods to be restored more quickly. It also automates image recognition tasks with Deep Learning.The company was established in 2014 and is based in London, England.
  • Constructor — The only site search and product discovery built for ecommerce KPIs. Delivering superior experiences with AI, NLP, data and personalization.
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Amplify Partners
VC Fund · Menlo Park, California, United States · 24 investments in United States Machine Learning startups

Amplify is the first investor for technical founders building the next generation of technical applications, tools, and platforms.

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Investment focus

  • Industry: Software, Information Technology, Artificial Intelligence
  • Stage:Series A, Seed, Series B
  • Geography: United States, Canada, Israel

Investor stats

  • Total investments: 235
  • Round size: Seed $1.6M–$11M; Series A $7M–$25M; Series B $15M–$87M
  • Lead/follow: 23% lead, 77% follow

Portfolio highlights

  • Einblick — Meet Einblick, the AI-native data notebook that writes and fixes code, plots beautiful charts, builds models, and much more.
  • Covariant — Covariant is a developer of artificial intelligence for robotics. Covariant is building the Covariant Brain, a universal AI to give robots the ability to see, reason and act on the world around them.
  • Chainguard — We build products and offer services that help protect organizations from software supply chain attacks and vulnerabilities.
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Two Sigma Ventures
VC Fund · New York, New York, United States · 24 investments in United States Machine Learning startups

We are an early-stage venture capital firm investing in transformative companies harnessing information growth and computing power to change the world.

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Investment focus

  • Industry: Software, Artificial Intelligence, Machine Learning
  • Stage:Series A, Series B, Seed
  • Geography: United States, Canada, Mexico

Investor stats

  • Total investments: 195
  • Round size: Seed $2M–$8M; Series A $7.5M–$68M; Series B $15M–$70M
  • Lead/follow: 25% lead, 75% follow
  • Last fund: Likely still investing — raised $400M in 2022

Portfolio highlights

  • Castor — Castor provides EDC, ePRO, eCOA, eConsent, IWRS, eTMF, eSource, CDMS & decentralized trial solutions on a single electronic clinical data management platform.
  • Osmo — Giving computers a sense of smell.
  • Ansel Health — Give your employees peace of mind with supplemental health insurance from Brella. Our plan offers more coverage, less hassle, and a faster, simpler claims experience.
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Founders Fund
VC Fund · San Francisco, California, United States · 23 investments in United States Machine Learning startups

Founders Fund is a San Francisco based venture capital firm investing in companies building revolutionary technologies.

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Investment focus

  • Industry: Software, Health Care, Information Technology
  • Stage:Series A, Seed, Series B
  • Geography: United States, United Kingdom, Germany

Investor stats

  • Total investments: 767
  • Round size: Seed $1.5M–$14M; Series A $5.5M–$42M; Series B $15M–$105M
  • Lead/follow: 34% lead, 66% follow
  • Last fund: Likely actively investing — fund raised in 2025

Portfolio highlights

  • Citrea — Bitcoin's First ZK Rollup
  • Polymarket — Bet on your beliefs
  • Workstream — Workstream is an automated hiring platform that helps companies employing hourly workers. The platform helped Jamba, Chick-fil-A, McDonald's, Dunkin', Applebee's, Auntie Anne's, Cinnabon to increase their bottom line and cost savings.Workstream was founded in 2017 and is headquartered in San Francisco, California, UnitedStates.
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8VC
VC Fund · San Francisco, California, United States · 23 investments in United States Machine Learning startups

8VC is a technology and life sciences investment firm that partners with founders to develop transformational technologies. The firm focuses on creating long-term economic and societal value through its investments across various sectors, including healthcare and logistics.

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Investment focus

  • Industry: Software, Health Care, Artificial Intelligence
  • Stage:Series A, Seed, Series B
  • Geography: United States, United Kingdom, Canada

Investor stats

  • Total investments: 461
  • Round size: Seed $2.7M–$12M; Series A $8M–$55M; Series B $16M–$175M
  • Lead/follow: 34% lead, 66% follow

Portfolio highlights

  • Latus Bio — Latus Bio focuses on developing innovative gene therapy candidates using precision delivery to enhance the lives of patients. Latus identified proprietary AAV capsids for clinical use. The company plans to administer low doses of its product candidates, aiming to improve clinical safety and manufacturing.
  • DataHub — DataHub Core is the #1 open source platform with a uniquely scalable and extensible metadata graph supporting manual and automated data management. DataHub Cloud is an enterprise-ready SaaS solution providing a fully-managed service of DataHub Core with additional AI-powered capabilities in discovery, observability, and governance to accelerateproduction-readiness of AI and data assets.
  • Flywheel.io — Flywheel is a data management and analysis platform built specifically for scientists and the researcher's workflow. They empower research momentum by focusing on data and medical image capture, content management, scientific computation, and collaboration. With reproducible research in mind, they combine open-source methods from topuniversities, a modern web user interface, and an extensible compute engine based on containerization technology. The result is a software platform to accelerate discovery and help researchers do science, not IT.Flywheel accelerates new scientific discoveries in life-science, biotech, and academic imaging research through cloud-scale collaboration. As a result, imaging researchers are able to avoid innovation bottlenecks, and accelerate discovery by doing more science, and less IT.
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Kleiner Perkins
VC Fund · Menlo Park, California, United States · 23 investments in United States Machine Learning startups

Kleiner Perkins is an American venture capital firm headquartered on Sand Hill Road in Menlo Park in Silicon Valley.

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Investment focus

  • Industry: Software, Information Technology, Health Care
  • Stage:Series B, Series A, Series C
  • Geography: United States, China, United Kingdom

Investor stats

  • Total investments: 1117
  • Round size: Series A $5M–$40M; Series B $10M–$71M; Series C $12M–$100M
  • Lead/follow: 30% lead, 70% follow
  • Last fund: Likely still investing — fund raised in 2022

Portfolio highlights

  • UiPath — Reinvent your workplace with the leading robotic process automation platform and learn how UiPath can help your company become a fully automated enterprise.
  • Mirage — Say hello to Captions, the only camera and editing app that automatically transcribes, captions and clips your talking videos for you.
  • Handshake — The largest expert network for learning, earning, and growing careers in the AI economy, giving everyone an accessible first step into an AI-powered career.
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Streamlined
VC Fund · San Francisco, California, United States · 23 investments in United States Machine Learning startups

We partner with seed-stage founders to build exceptional companies.

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Investment focus

  • Industry: Software, Artificial Intelligence, Information Technology
  • Stage:Seed, Series A
  • Geography: United States, Mexico, Colombia

Investor stats

  • Total investments: 233
  • Round size: Seed $1.5M–$9M; Series A $4M–$23M
  • Lead/follow: 17% lead, 83% follow
  • Last fund: Likely still investing — raised $102M in 2022

Portfolio highlights

  • RedDoor — It's been a fast-paced journey here at RedDoor and we are on our way to the next success...
  • Drivably — Drivably helps dealers acquire the right cars they need without the stress.
  • Flip — Flip is a social shopping app that connects customers to beauty products through video reviews.Flip’s Social Shopping platform blends the power of social media with the buying appeal of e-commerce. Customers receive pieces of clothing based on their preferences, likes, and interactions. The fitting room is flipped into the living room, where theytry on everything and share photos on the Flip social platform to get a thumbs up or down from friends on what looks best.
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Liquid 2 Ventures
VC Fund · San Francisco, California, United States · 22 investments in United States Machine Learning startups

Liquid2 Ventures provides technology startups with seed-stage investments and is based in San Francisco, California. The firm was founded in 2015 by Joe Montana, Mike Miller, and Michael Ma.

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Investment focus

  • Industry: Software, Artificial Intelligence, Information Technology
  • Stage:Seed, Series A, Pre-Seed
  • Geography: United States, Mexico, Canada

Investor stats

  • Total investments: 427
  • Round size: Seed $1.7M–$9M; Pre-Seed $1M–$5M; Series A $5.6M–$56M
  • Lead/follow: 1% lead, 99% follow

Portfolio highlights

  • HelpNow — HelpNow Corporate Site
  • Patlytics — Patent discovery, analytics, comparison, and workflow. Simplified via Artificial Intelligence.
  • Tako — Tako is a deep research platform that turns data into insightful analysis, chats and reports.
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Ulu Ventures
VC Fund · Palo Alto, California, United States · 22 investments in United States Machine Learning startups

With deep connections to Stanford and Silicon Valley, Ulu Ventures is a venture capital firm that actively seeks and funds women and diverse founder teams.

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Investment focus

  • Industry: Software, Financial Services, FinTech
  • Stage:Seed, Series A
  • Geography: United States, Mexico, Nigeria

Investor stats

  • Total investments: 253
  • Round size: Seed $1M–$7.2M; Series A $2.5M–$25M
  • Lead/follow: 15% lead, 85% follow

Portfolio highlights

  • Kogniz — Explore the latest phone apps and stay protected with expert tips on mobile security, privacy, and safe tech use.
  • Watson — Watson's mission is to make rent rewarding. We enable landlords to offer their residents cash back rewards for things like paying rent on time, renewing a lease, or engaging in a community event, along with deals from local and online merchants. Landlords get happier residents, increased leasing velocity, and higher tenant retention. Rentersget a way to build equity by paying rent. Neighborhood businesses get local, sustained traffic. Online brands get exposure to movers with high spending intent. Our vision is a more equitable housing model for 100mm+ renters, landlords, and neighborhood businesses.
  • Cambium — Saving wood to save the planet. By revolutionizing supply chains, we introduce the world's first carbon smart material.
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Google Ventures
VC Fund · Mountain View, California, United States · 22 investments in United States Machine Learning startups

GV supports innovative founders moving the world forward.

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Investment focus

  • Industry: Software, Health Care, Biotechnology
  • Stage:Series A, Series B, Seed
  • Geography: United States, United Kingdom, Israel

Investor stats

  • Total investments: 983
  • Round size: Seed $1M–$13M; Series A $5.4M–$86M; Series B $15M–$105M
  • Lead/follow: 32% lead, 68% follow
  • Last fund: May invest from a new fund soon — raised $100M in 2014

Portfolio highlights

  • Allara — Allara is your all-in-one virtual care team for hormonal, metabolic & gynecological conditions such as PCOS and Endometriosis.
  • Smarterer — Individuals and Fortune 500 companies use Smarterer to help close the gap between the skills they have and the skills they need. Their dynamic assessment engine leverages the freshest crowdsourced tests around, to rapidly pinpoint skill level with a credible score. In November 2014, Pluralsight, the global leader in online learning for serioussoftware developers, IT specialists and creative technologists, acquired Smarterer. As the world's largest curated e-learning library for professionals, the company offers instant access to more than 3,500 courses authored by top experts. Smarterer will continue to power crowdsourced assessments for freelancer marketplaces, e-learning providers and enterprise companies anywhere people need to prove their skills to connect with professional opportunities. The Smarterer community has answered over 56 million during 1.7 million test sessions, across hundreds of tests.
  • Merida Biosciences — Merida Biosciences is a new biotech company focused on developing precision treatments, particularly for autoimmune diseases. The company utilize a protein engineering platform to create unique Fc therapeutics, aiming to selectively bind to specific antibodies.
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M12 - Microsoft's Venture Fund
VC Fund · San Francisco, California, United States · 21 investments in United States Machine Learning startups

M12 are a venture capital fund, by Microsoft. Our investment teams are based globally to support your business from start up funding to Series C investment.

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Investment focus

  • Industry: Software, Artificial Intelligence, Machine Learning
  • Stage:Series A, Series B, Series C
  • Geography: United States, Israel, United Kingdom

Investor stats

  • Total investments: 242
  • Round size: Series A $7.8M–$46M; Series B $12M–$58M; Series C $21M–$100M
  • Lead/follow: 35% lead, 65% follow

Portfolio highlights

  • Upscale — Upscale your brand with AI-powered video ads that generate, target, and optimize for real performance on TV and digital platforms.
  • Eventual — Eventual is tackling one of the hardest infrastructure problems in AI: making multimodal data (images, video, audio) as easy to process as SQL tables. While every company races to build AI applications, they're stuck forcing tools designed for bank transactions to handle petabytes of video and images. Our platform eliminates months ofinfrastructure work, letting developers query massive multimodal datasets with simple Python scripts that automatically scale. Built on our open-source Daft engine, we deliver 10x performance improvements and handle all the messy realities of production AI workloads—from out-of-memory errors to flaky API calls. We're already processing petabytes daily at companies like Amazon, Together AI, and CloudKitchens, powering everything from autonomous vehicles to foundation model training
  • Helpshift — Helpshift is an AI-native player engagement platform that combines technology, AI, and human experts to power gaming support, trust & safety and community.
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SignalFire
VC Fund · San Francisco, California, United States · 21 investments in United States Machine Learning startups

Engineered to ignite your growth, SignalFire is the first venture capital firm built as a technology company. Data, advice, and support from seed to scale.

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Investment focus

  • Industry: Software, Artificial Intelligence, Information Technology
  • Stage:Series A, Seed, Series B
  • Geography: United States, Israel, Germany

Investor stats

  • Total investments: 272
  • Round size: Seed $2.2M–$12M; Series A $10M–$45M; Series B $20M–$75M
  • Lead/follow: 44% lead, 56% follow

Portfolio highlights

  • SigNoz — SigNoz is an open-source observability tool powered by OpenTelemetry. Get APM, logs, traces, metrics, exceptions, & alerts in a single tool.
  • Form Health — Form Health's tele-health program takes a medical & personalized approach to weight loss. Get weight loss expertise wherever you are & improve your health today!
  • Flock Freight — Flock Freight is reimagining and reinventing the freight industry by relentlessly eliminating inefficiency and waste through algorithmic pooling.Working at the intersection of cutting-edge technology and human-centric logistics management, Flock Freight tailors its shipping experience to meet your business’s needs. Flock Freight seamlessly poolsany freight to find the perfect route, avoiding terminals and risky offloads so that a shipment travels safely and directly to its destination, damage-free. The result: on-time delivery with every shipment—guaranteed.With venture capital from Google Ventures and SignalFire, Flock Freight is one of the largest startups in San Diego, California. The company's team is obsessed with aggressively growing its customer base, constantly improving the technology platform, and delivering a superior customer experience. Flock Freight aims to fundamentally change the $60 billion LTL freight industry across North America with FlockDirect—one pooled shipment at a time.
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BoxGroup
VC Fund · New York, New York, United States · 21 investments in United States Machine Learning startups

BoxGroup is an early stage investment fund focused on technology companies. Contact Us: hello@boxgroup.com

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Investment focus

  • Industry: Software, Health Care, Artificial Intelligence
  • Stage:Seed, Series A, Series B
  • Geography: United States, Mexico, Canada

Investor stats

  • Total investments: 521
  • Round size: Seed $1.5M–$8.5M; Series A $5.5M–$32M; Series B $16M–$80M
  • Lead/follow: 5% lead, 95% follow

Portfolio highlights

  • Universe — Universe is the first website builder and commerce platform built for mobile devices. With its magical drag and drop interface, anyone can easily create a website and start selling online in minutes from anywhere.
  • David Energy — David Energy is an electricity provider that designs, builds, and manages onsite energy grids. The company empowers buildings with the tools needed to maximize onsite energy and bring transparency to a traditionally opaque, commoditized industry. It provides hands-on expertise and on the ground support, all delivered through its software platform.Founded in 2017, David Energy is headquartered in Brooklyn, New York.
  • Gradient — Gradient Security Mesh. Prevents breaches before they happen by securing what others can't. Cybersecurity that goes beyond zero trust.
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TSVC
VC Fund · Los Altos, California, United States · 21 investments in United States Machine Learning startups

Founded in 2010, TSVC (formerly TEEC Angel Fund) is proud to be a leading early-stage venture capital fund in Silicon Valley.

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Investment focus

  • Industry: Software, Artificial Intelligence, Health Care
  • Stage:Seed, Series A
  • Geography: United States, China, Canada

Investor stats

  • Total investments: 234
  • Round size: Seed $500k–$7M; Series A $2M–$27M
  • Lead/follow: 8% lead, 92% follow
  • Last fund: Likely still investing — fund raised in 2021

Portfolio highlights

  • Dexmate — Dexmate is a robotics startup focused on developing general-purpose mobile robots. The company specializes in robots with manipulation capabilities. Their technology aims to enhance automation across various industries.
  • EGI Battery — EGI Battery manufactures batteries for autonomous systems, aviation, robotics, and mobility.
  • Petal Surgical — Petal is a surgical technology company pioneering incisionless surgery through Acoustic Sculpting, a proprietary form of boiling histotripsy. Our platform uses focused sound waves to precisely destroy harmful tissue without cuts, heat, or toxicity offering gentler alternative to traditional surgery.
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Emergent Ventures
VC Fund · San Mateo, California, United States · 20 investments in United States Machine Learning startups

Day 0 backers for ambitious founders. Based in Silicon Valley, Emergent Ventures partners closely, provides deep GTM support and helps build category-defining companies in enterprise AI, Cloud, and beyond.

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Investment focus

  • Industry: Software, Artificial Intelligence, Information Technology
  • Stage:Seed, Series A, Pre-Seed
  • Geography: United States, India, Canada

Investor stats

  • Total investments: 86
  • Round size: Seed $1M–$6M; Pre-Seed $900k–$5.2M; Series A $3.5M–$32M
  • Lead/follow: 38% lead, 62% follow
  • Last fund: May invest from a new fund soon — raised $76M in 2021

Portfolio highlights

  • Press Hook — Where Brands and Media Connect
  • Prezent AI — Presentation productivity platform for enterprise teams. Add zen to your presentations!
  • SimpliContract — SimpliContract is the industry's most capable AI-first CLM platform, purpose-built for enterprises' legal, sales, and procurement teams. Learn more now.
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Social Starts
VC Fund · San Francisco, California, United States · 20 investments in United States Machine Learning startups

Social Starts is a $60M+ venture capital partnership with a uniquely data-driven approach to investing in moment-of-inception and Series A financing rounds.

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Investment focus

  • Industry: Software, Health Care, Artificial Intelligence
  • Stage:Seed, Series A
  • Geography: United States, Germany, United Kingdom

Investor stats

  • Total investments: 289
  • Round size: Seed $100k–$3.7M; Series A $3.2M–$15M
  • Lead/follow: 1% lead, 99% follow

Portfolio highlights

  • Dyad Medical — Dyad Medical develops software that automatically analyzes the content of cardiac and cardiovascular images. Its software applications support both treatment decision making in the clinic and analysis in research, enabling researchers to optimize observations and conclusions. It was founded in 2018 and headquartered in Boston, Massachusetts.
  • Original Stitch — PLATINUMTOTO hadir sebagai situs togel macau di Indonesia yang sangat populer di kalangan togelers platinumtoto dengan jackpot 4D setiap hari nya
  • Bark Technologies — Learn how Bark's parental controls can help you protect your kids online and in real life with monitoring, screen time controls, and more.
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Felicis
VC Fund · Menlo Park, California, United States · 20 investments in United States Machine Learning startups

Backing founders building iconic companies that transcend boundaries

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Investment focus

  • Industry: Software, Artificial Intelligence, SaaS
  • Stage:Series A, Seed, Series B
  • Geography: United States, Canada, Germany

Investor stats

  • Total investments: 528
  • Round size: Seed $1.5M–$12M; Series A $4M–$40M; Series B $10M–$79M
  • Lead/follow: 27% lead, 73% follow

Portfolio highlights

  • Supabase — The Open Source Alternative to Firebase.
  • Depot — The fastest place to build Docker images.
  • Hitloop — Reliable Artificial Intelligence and Machine Learning solutions for your organization using our breakthrough speech, language, vision and multi-modal deep learning models
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Costanoa Ventures
VC Fund · Palo Alto, California, United States · 20 investments in United States Machine Learning startups

Bold Ideas Enduring Companies

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Investment focus

  • Industry: Software, Artificial Intelligence, Information Technology
  • Stage:Seed, Series A, Series B
  • Geography: United States, Brazil, Egypt

Investor stats

  • Total investments: 239
  • Round size: Seed $2.5M–$10M; Series A $5.6M–$25M; Series B $11M–$60M
  • Lead/follow: 45% lead, 55% follow
  • Last fund: Likely actively investing — fund raised in 2024

Portfolio highlights

  • Glow — Glow is an insurance company that aims to transform insurance to better protect people. The company is working toward holistic coverage for work, life and everything in between. Glow was founded in 2018 and based in San Francisco, California.
  • Highline — Highline is a new way to reduce credit risk and expand access. Customers can now pay bills directly from their payroll. Customers gain peace of mind that payments are taken care of without worrying about bank account balances. The gainfully employed deserve access to credit, and Highline technology now makes that possible.
  • Rerun — Iterate faster on robotics learning with unified infrastructure. Ingest, visualize, annotate, query, and transform - from collection to training.
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Foundation Capital
VC Fund · Palo Alto, California, United States · 20 investments in United States Machine Learning startups

For 30 years we've backed extraordinary founders from day zero.

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Investment focus

  • Industry: Software, Information Technology, Artificial Intelligence
  • Stage:Seed, Series A, Series B
  • Geography: United States, United Kingdom, Canada

Investor stats

  • Total investments: 575
  • Round size: Seed $1.5M–$10M; Series A $6M–$30M; Series B $6M–$50M
  • Lead/follow: 31% lead, 69% follow
  • Last fund: Likely actively investing — fund raised in 2025

Portfolio highlights

  • Addi — Addi is a technology company that provides credit and banking solutions. Addi is headquartered in Bogota, Colombia.
  • Cyphort — Cyphort has developed Next Generation Distributed Software Platform to provide the broadest enterprise visibility and accurate detection of advanced threats & evasion techniques, and zero-day attacks by utilizing behavioral analytics, machine learning, and Long-Data Security-Analytics.Cyphort's innovative approach detects the mostadvanced threats through a highly accurate platform combined with validation and prioritization of threats in context of the organizations eco-system. Through this process Cyphort produces highly customized Actionable Intelligence to users.The Cyphort Distributed Platform has been build with flexibility allowing for seamless integration and detection not only at the edge and network layers but also in virtual infrastructures, cloud environments, and mobile platforms.
  • Graphcore — Graphcore has built a new type of processor for machine intelligence to accelerate machine learning and AI applications for a world of intelligent machines
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Matrix
VC Fund · San Francisco, California, United States · 20 investments in United States Machine Learning startups

We're an early stage VC firm that leads pre-seed through Series A rounds and works with founders to help them win.

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Investment focus

  • Industry: Software, Artificial Intelligence, Information Technology
  • Stage:Series B, Series A, Series C
  • Geography: United States, China, India

Investor stats

  • Total investments: 493
  • Round size: Series A $4.9M–$25M; Series B $8M–$44M; Series C $10M–$100M
  • Lead/follow: 34% lead, 66% follow
  • Last fund: May invest from a new fund soon — raised $300M in 2018

Portfolio highlights

  • Panzura — Radically simplify and secure your unstructured data with Panzura's award-winning cloud data management platform. Enjoy the flexibility of hybrid clouds, access, security, and control through a single global file system native to the cloud.
  • Salsify — The Salsify Commerce Experience Management (CommerceXM) Platform powers engaging shopping experiences at every stage of the buying journey.
  • Apollo GraphQL — Connect agents and apps to GraphQL and REST APIs with proven infrastructure trusted by enterprise leaders.
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Cultivation Capital
VC Fund · St Louis, Missouri, United States · 19 investments in United States Machine Learning startups

Cultivation Capital invests in young companies whose ideas have potential to transform the way we live and work.

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Investment focus

  • Industry: Software, SaaS, Health Care
  • Stage:Seed, Series A
  • Geography: United States, Australia, Israel

Investor stats

  • Total investments: 214
  • Lead/follow: no public data

Portfolio highlights

  • Hydrosat — Hydrosat provides daily, high-resolution thermal and multispectral infrared imagery of the entire Earth. Leveraging our first-in-history thermal capabilities, we also provide analytics solutions to solve climate and agriculture issues.
  • Swell — Helping local businesses capture and retain customers. Swell is an automated growth platform that helps businesses find new customers and turn their feedback into reviews, referrals, and a booming bottom line. It helps businesses get discovered in local searches, learn from customer feedback, and enhance their reputation through true customersentiment. www.swellcx.com Swell serves multiple industries including healthcare, retail, service, hospitality and tourism. We believe software should be easy-to-use, simple to integrate, and effective.Learn more at www.swellcx.com
  • RouteSense — RouteSense is a payments data infrastructure company building the first standardized approach to MID health. Our platform aggregates transaction data across the full stack, calculates real-time health scores for every merchant account, and enables intelligent routing to maximize approvals and prevent compliance violations. We serve merchants, ISOs,PSPs, and acquiring banks who need visibility and control over their payment portfolios.
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RRE Ventures
VC Fund · New York, New York, United States · 19 investments in United States Machine Learning startups

RRE is a boutique venture capital firm with 30 years of experience, backing bold early-stage founders across diverse sectors. We provide deep expertise, AI-driven insights, and committed partnerships to help companies build and persevere for the long term.

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Investment focus

  • Industry: Software, Financial Services, Internet
  • Stage:Series A, Seed, Series B
  • Geography: United States, Canada, United Kingdom

Investor stats

  • Total investments: 506
  • Round size: Seed $1.1M–$7M; Series A $2.3M–$27M; Series B $7.3M–$32M
  • Lead/follow: 24% lead, 76% follow
  • Last fund: Likely still investing — raised $250M in 2023

Portfolio highlights

  • Poncho — Fun daily weather forecasts, delivered by a cat. Available on Facebook Messenger, iPhone, and Android.
  • Spring Health — Eliminating barriers to mental healthcare. Clinically-proven technology with world-class providers to deliver precisely what your employees need.
  • Medallia Agent Connect — Stella Connect is a customer feedback and quality management platform built specifically for customer service teams. Companies use Stella Connect to drive agent engagement and to measure and improve their service performance.
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1984 Ventures
VC Fund · San Francisco, California, United States · 19 investments in United States Machine Learning startups

1984 Ventures is an early-stage venture capital firm that seeks to invest in fintech, healthcare, SaaS, e-commerce, and consumer sectors.

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Investment focus

  • Industry: Software, Health Care, Artificial Intelligence
  • Stage:Seed, Series A, Pre-Seed
  • Geography: United States, Mexico, Egypt

Investor stats

  • Total investments: 129
  • Lead/follow: no public data

Portfolio highlights

  • Alex AI — Alex is the AI recruiter that puts sourcing, screening, and scheduling on autopilot. Fast-track vetting so you interview the best in days.
  • VoiceBit — AI-powered phone and web ordering that keeps every dollar and every customer yours. Answer every call, take orders, and book reservations 24/7. Set up in minutes.
  • teachme.to — Find top-rated coaches for private lessons in tennis, golf, pickleball and more. Expert instruction and training for all ages and skill levels.
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Flying Fish Partners
VC Fund · Seattle, Washington, United States · 19 investments in United States Machine Learning startups

Investing in the transformative power of Artificial Intelligence and Machine Learning.

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Investment focus

  • Industry: Software, Artificial Intelligence, Machine Learning
  • Stage:Seed, Series A
  • Geography: United States, Canada, United Kingdom

Investor stats

  • Total investments: 68
  • Lead/follow: no public data

Portfolio highlights

  • Latent Labs — Latent Labs is making biology programmable to transform health and sustainability for the benefit of all.We are a frontier AI lab building foundational models that capture the fundamentals of biology. We empower partners with breakthrough generative AI to gain unprecedented control over molecular biology, creating new antibodies, optimizingexisting enzymes, and advancing genetic engineering.Contact us to work with us today.
  • Variational AI — We are a team of AI/machine learning and business specialists using advanced generative AI for drug discovery. We collaborate closely with biopharmaceutical partners to develop new therapeutics across disease areas, aiming to positively impact lives.
  • Picnic — The Picnic Pizza System is a modular, easy-to-use, automated pizza assembly system that saves time, money, and labor without compromising quality.
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Machine Learning Investor funding in United States at a glance

Stats across 7.7k deals from 7.9k investors.

7.9k
investors
in United States Machine Learning startups
7.7k
deals
in United States Machine Learning startups
$5M
median round
in United States Machine Learning startups
31%
lead investors
lead at least one round
31%
Seed
most common funding stage
72/28
VC / Angel
share of investor count

Access all 7891 investors in United States Machine Learning startups.

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