Top 50 Medical Device Startup Investors in United States

Investor	Medical Device United States investments
Innova Memphis	71
SOSV	20
Portfolia	20
Broadview Ventures	19
CincyTech	18
HealthTech Capital	18
Good Growth Capital	17
MB Venture Partners	16
North Coast Ventures	16
Arboretum Ventures	15
TEDCO	15
Texas HALO Fund	15
Maine Angels	15
Boston Harbor Angels	15
Oxford Finance LLC	15
Connecticut Innovations	14
New Enterprise Associates	14
Wavemaker 360	14
Oxford Bioscience Partners	13
U.S. Venture Partners	13
Ben Franklin Technology Partners of Southeastern Pennsylvania	13
Khosla Ventures	13
Horizon Technology Finance	13
Catalyst Health Ventures	12
Versant Ventures	12
Wisconsin Investment Partners	12
Delphi Ventures	12
Canaan Partners	12
Sand Hill Angels	12
Catalyst Health Ventures	12
Split Rock Partners	11
Houston Angel Network	11
Kleiner Perkins	11
Tech Coast Angels	11
Gaingels	11
St. Louis Arch Angels	10
Silicon Valley Bank	10
Rev1 Ventures	10
DeNovo Ventures	10
Shangbay Capital	10
Three Arch Partners	10
Virginia Venture Partners	10
Third Rock Ventures	10
Life Science Angels	10
Keiretsu Capital	10
Sante Ventures	10
Green Park & Golf Ventures	10
Morgenthaler Ventures	10
Keiretsu Forum	9
Invest Nebraska	9

Founded in 2007 by the Memphis Bioworks Foundation, Innova is a pre-seed, seed and early-stage investor focused on starting and funding high-growth companies in the Biosciences, Technology and AgBio fields across the state of Tennessee. Innova links capital with great ideas to create groundbreaking products and services.At Innova we invest instart-up companies, help them grow, and then assist them in linking with established corporations for licensing, buy-outs or further investments. We provide the synergy of experienced management, market expertise and venture capital to accelerate the development of new products and services into viable business units that can stand on their own and then take their place with a mature market leader, if desired.Whether an innovation is still on the drawing board or stalled in the market place the Innova staff has the expertise, skills, and experience to envision and create a functioning business unit that is prepared to thrive in the market place. Technical know-how, market-proven staffing, and "just-right" funding assure the greatest chance possible for success.

Investment focus

Health Care, Medical, Medical Device
Seed, Pre-Seed, Convertible Note
United States, Argentina, United Kingdom

Portfolio highlights

Rantizo — Fly more acres, deliver better service. The equipment, tools, and expertise you need to be the grower's first call for drone spray services.
iYOTAH Solutions — iYOTAH Solutions is a transformational SaaS technology company that connects data to help the animal protein industry thrive.
Glanris — Glanris developed a completely green, non-toxic, filtration media for water purification from an agriculture by-product. This agricultural product is grown around the world, is plentiful, and can be used locally to ensure clean drinking water in developing countries. It also gives local farmers a significant additional income source for a productthat today they are throwing away.This media has been independently tested over the last two years of development and is ready for production.

SOSV is a global, deep tech venture capital firm that operates the HAX and IndieBio startup development programs focused on human and planetary health. SOSV invests $500,000 in startups at their inception as they onboard either HAX or IndieBio for a 4-6 month period designed to accelerate the raise of their next institutional round. SOSV joins thelater rounds of HAX and IndieBio graduates. HAX, based in a 35,000 sq ft facility in Newark, NJ, is equipped with machine tools, 3D printers, chemical, electrical and mechanical engineering labs, as well as on-staff engineering and design experts. SOSV's IndieBio has locations in NYC and San Francisco, both of which offer extensive services and facilities to founders including on-site BSL-2 labs, well equipped lab benches and hoods, and advanced lab equipment, such as chromatography equipment.

Investment focus

Biotechnology, Health Care, Software
Seed, Convertible Note, Pre-Seed
United States, India, United Kingdom

Portfolio highlights

NovoNutrients — NovoNutrients is working to turn waste CO2 into high-value, low-cost proteins and additives for food and feed by developing proprietary microbes and advanced gas fermentation systems.
OncoPrecision — We're developing personalized assays to determine the most suitable medication for cancer therapy at the patient level. Through our proprietary Drug Activity and Resistance Test, oncologists will be able to make data-driven decisions regarding cancer therapy selection based on patient-derived samples. Our goal is to democratize access toPrecision Oncology and improve cancer patients' lives.
Sodex Innovations — Sodex Innovations is a company which is specialized in developing assistance-systems and automating-kits for excavators

Investing Funds Designed for Women Backing Innovative Companies We Want in the World - For Returns and Impact

Investment focus

Health Care, Software, Biotechnology
Seed, Series A, Series B
United States, Canada, Argentina

Portfolio highlights

Attn: Grace — Attn: Grace is a sustainable wellness brand designed for women. Starting with bladder leakage, they're creating thoughtful, more sustainable solutions for life’s inconvenient truths, one challenge at a time.
Prime Roots — Prime Roots is on a mission to provide a better cut of meat for every type of eater. Rooted in koji, Prime Roots is able to replicate the taste and texture of meat without any of the environmental costs of animal proteins.
Harvest Thermal — We are manufacturers of the cleanest home energy solution on the market today. We offer a cloud-enabled, ultra-clean heating, cooling and hot water system for residential customers. The brains of the system is our award-winning Harvest Pod that slashes carbon emissions, saves on utility bills, and

Broadview Ventures, Inc. (Broadview) was established in 2008 as a new program conceived by the Leducq family. Through Broadview, the trust will work to accelerate the development of promising technology in cardiovascular and neurovascular disease through targeted investment in and support of early stage technology ventures.The FoundationLeducq, based in Paris, France, is the beneficiary of a charitable trust. In order to further the Foundation Leducq's mission in cardiovascular and neurovascular disease, the trust has made funds available to Broadview to develop a program which will promote early state technology in these fields through investments, licensing agreements and consortium funding arrangements, as well as professional, management and consulting support.With this initiative the trust joins other leaders in the venture philanthropy movement in seeking creative solutions to the problem of what is commonly referred to as the 'translational gap', a significant component of which is a lack of funding at a critical moment in the development of new technology and science.

Investment focus

Health Care, Biotechnology, Medical Device
Series A, Seed, Debt Financing
United States, Canada, Israel

Portfolio highlights

IsomAb — IsomAb evaluate and develop isoform specific antibodies to treat disease.
Nyra Medical — MitraPlug has created a catheter-plug technology for repairing a leaky mitral valve in the heart.This adjustable device needs only a two-inch surgical incision and can be inserted directly into the heart. Then the cardiologist can use the catheter to adjust the size and position of the plug to correct the leakage. When correctly fitted, thecatheter is removed, and the incision is closed, leaving only a small scar.
Cardiosense — Cardiosense offers a physiological waveform AI platform to develop predictive biomarkers for the detection and treatment of disease. Its platform leverages multi-modal sensors and industry-leading AI to develop predictive biomarkers for the detection and treatment of disease.

CincyTech is one of the Midwest's most active seed funds, investing in disruptive human health and technology companies in Ohio.

Investment focus

Software, Health Care, Biotechnology
Seed, Series A, Series B
United States

Portfolio highlights

Amify — We help brands selling on Amazon maximize sales and profitability by providing complete strategy, management and operational services.
Invirsa — Invirsa is developing a unique, broad platform based on a naturally occurring small molecule (INV-102) that has demonstrated enhanced immune response to infection. INV-102 not only reduces viral infection, and potentially bacterial replication, it also reduces inflammation, while enhancing the bodies wound healing response. Invirsa'stechnology is first being developed in the ophthalmology and pulmonary space.Invirsa’s technology has the potential to be a first line therapy for common infectious diseases, whether it's the 100 million viral pulmonary infections or the 5 million infectious conjunctivitis cases that occur every year in the US alone.
Voxel — Voxel utilizes advanced mathematics and artificial intelligence to rapidly generate functionally graded meta-materials for high performance applications through additive manufacturing. We provides performance leaps in the defence, automotive, aerospace, medical, industrial, and other demanding areas and unlock new capabilities for our customers.

Private angel investors and corporate venture ecosystem investing in healthtech, digital health and other healthcare technologies startups

Investment focus

Health Care, Medical Device, Medical
Seed, Series A, Convertible Note
United States

Portfolio highlights

SafKan Health — OtoSet® by SafKan Health is the first FDA Cleared automated ear cleaning device for the 35 million Americans affected by impacted earwax - the leading cause of conductive hearing loss.
GT Metabolic Solutions — GT Metabolic Solutions has developed minimally-invasive incisionless bypass technology for bariatric, metabolic and digestive surgery.
Wavely Diagnostics — Wavely Diagnostics is pioneering the future of remote digital diagnostics and enabling telehealth growth by leveraging smartphone technology to address pediatric care.

Good Growth Capital is an early-stage venture capital firm known for its expertise in finding, assessing and cultivating complex science and technology.

Investment focus

Health Care, Software, Information Technology
Seed, Series A, Convertible Note
United States, France, Israel

Portfolio highlights

VenoStent — VenoStent is a clinical-stage tissue engineering company that’s developed tunable, bioabsorbable smart polymer wraps in order to fundamentally transform the 5 million vascular surgeries performed each year.
Swift Solar — Swift Solar is a startup manufacturing lightweight solar panels that are cheaper and more efficient than conventional panels using perovskite materials.
Found Energy — Found Energy's aluminum-thermal power systems extract renewable energy from aluminum at double the energy density of diesel and at a competitive cost. Compact, modular, safe, and carbon-free, our technology makes industrial decarbonization practical.

MB Venture Partners in Memphis, TN provides venture capital for life sciences: medical device, biotechnology companies, products for musculoskeletal diseases

Investment focus

Health Care, Medical, Medical Device
Seed, Series B, Series C
United States, Israel

Portfolio highlights

Cast21 — The future of orthopedic technology has arrived. Cast21 braces are designed for your active lifestyle.
SweetBio — SweetBio is a Memphis, Tennessee based medical device company specializing in bioengineering honey-incorporated materials for wound care.
Lineus Medical — Lineus Medical is a medical device company focused on reducing IV complications for patients and providers all over the world.

North Coast Ventures (formerly North Coast Angel Fund) is comprised of four contributed capital funds with a focus on early-stage technology investments. Our membership consists of a number of Ohio's leading investors, entrepreneurs, and business leaders who are dedicated to accelerating early-stage ventures.North Coast Ventures members playan active role by generating deal flow, serving on due diligence teams, working with portfolio companies, or serving on the Investment Screening and Executive Committees. Through this involvement, our goal is to provide a supportive environment for our portfolio companies and ultimately enhance the performance of our Fund.Northeast Ohio has a long tradition of active and successful angel investing, but until recently, the success of this crucial form of funding has hinged on the efforts of a relatively small number of individual investors. As the region’s first professionally managed angel fund, North Coast Angel Fund works to improve the early-stage funding environment for both entrepreneurs and investors.

Investment focus

Health Care, Software, Medical Device
Series A, Seed, Funding Round
United States

Portfolio highlights

Narratize — Our generative AI software helps innovative enterprises quickly produce impactful, accurate, compelling communications and deliverables by distilling their ideas and expertise.
Redi.Health — Redi.Health is a healthcare technology company that develops health management platforms for patients. The company aims to connect patients with chronic diseases to patient support programs. These programs are created in partnership with pharmaceutical manufacturers and are always free to the patient.
OnStation — Productivity app for roadway workers and that provides instant jobsite location, access to plans and design, and a team chat platform.

For over 20 years we have been a successful healthcare venture capital firm rooted in the Midwest. Check out our portfolio companies.

Investment focus

Health Care, Biotechnology, Medical
Series B, Series A, Series C
United States, Canada

Portfolio highlights

RareCyte — Rarecyte provides precision medicine solutions focused on multiplexed analysis of cells and tissue with applications in both research and clinical diagnostics.
Avation Medical — Avation Medical is an innovative advanced neuromodulation & digital health company pioneering wearable neuromodulation therapies.
Reprieve Cardiovascular — Reprieve Cardiovascular is bringing intelligence to decongestion management to safely accelerate fluid removal for heart failure patients.

TEDCO was created by the Maryland State Legislature in 1998 to facilitate the transfer and commercialization of technology from Maryland’s research universities and federal labs into the marketplace and to assist in the creation and growth of technology-based businesses in all regions of the State. TEDCO is an independent organization thatstrives to be Maryland’s lead source for entrepreneurial business assistance and seed funding for the development of startup companies in Maryland’s innovation economy. In Maryland and beyond, TEDCO is a resource of mentoring, funding and networking for entrepreneurs and start-ups that need guidance as they bring innovative concepts to market. TEDCO is more than an early stage funding resource. It is the hub of Maryland’s entrepreneurial network where startups find mentors, organizational assistance, facilities for daily operations, and a roadmap for success.

Investment focus

Health Care, Software, Information Technology
Seed, Grant, Pre-Seed
United States, Canada

Portfolio highlights

Baltimore Jewelry Center — The Baltimore Jewelry Center is a community arts education space passionate about teaching jewelry making and metals skills. We provide high caliber instruction and access to studio tools and equipment for jewelry-making.
Allegany College of Maryland — The main campus of the Allegany College of Maryland rests in Cumberland, off of Willow Brook Road. As the biggest of the school’s three campuses, Cumberland has all of the amenities you may never have expected from a small college. Each building is equipped with the latest modern facilities, making for an up-to-date learning experience. There arealso dining areas, a student lounge, and a state of the art physical education building with a gym and swimming pool.Within the list of extensive fields of study are the social, biological and political sciences, criminal justice and criminology, many fields in the humanities, accounting and business programs, automotive and other technical studies, culinary arts, hotel and restaurant management, forest technology, health fields including dental hygiene, physical education, nursing, and pharmacy technician studies, and more. Advice is not something you’ll be lacking at Allegany. The tutoring services can help you through any academic rough patches. Transfer advising can prepare you to go to a four-year college. Career advising counselors can help you pick a major, assess your interests and aptitudes, and help find you a career.Along with federal financial aid and veteran’s benefits, Allegany also offers a catalog full of scholarships from major related aid to local endowments to eligible students.
Baltimore Underground Science Space — Baltimore Underground Science Space is a non-profit public laboratory that provides access to the lab as well as workshops and seminars.

Early Stage Venture Investments

Investment focus

Health Care, Medical Device, Software
Seed, Convertible Note, Series A
United States, Canada, Hungary

Portfolio highlights

Flourish Collective — FlourishFund is a digital platform that empowers and supports new and expecting families. The platform consists of two parts: a marketplace with evidence-based goods and vetted maternal wellness services and a funding mechanism for friends and families to contribute to a positive birth and parenting journey.
Drusolv Therapeutics — Drusolv Therapeutics is a clinical-stage drug company developing a novel, high-dose statin for early intervention in age-related macular degeneration. Their product ocustatin is aimed at patients who are still in the intermediate stage of the disease and currently have very limited options to prevent progression to late-stage vision loss. Ocustatinwas developed at Harvard University and has been validated in a very successful proof-of-concept clinical trial that showed a 75% reduction in progression to late-stage blindness. John Edwards, the founder and CEO of Drusolv, is a serial entrepreneur with extensive experience in AMD.
Vartega — Vartega is a technology development company specializing in the carbon fiber-reinforced plastic recycling process. We have developed alternative technology, processes, and equipment to provide low-cost carbon fiber for use in mass market applications.

Maine Angels they make investments with entrepreneurs with an emphasis on businesses.

Investment focus

Software, Health Care, Biotechnology
Seed, Funding Round, Angel
United States

Portfolio highlights

HighByte — HighByte is an industrial software development company in Portland, Maine building solutions that address the data architecture and security challenges created by Industry 4.0.
TOP the organic project — 100% Organic Cotton Period Care. Organic Tampons, Pads, First Period Kit & Bulk Period Products. Women-owned, eco-friendly, plant-based and sustainable. With every subscription, TOP gives back to women in need.
Pumpspotting — connect over breastfeeding, milk, motherhood, and the best places to nurse and pump. nurse, pump, nourish, connect.

Boston Harbor Angels is a group of proven business leaders interested in investing a portion of their assets in high growth, early stage companies. The group was formed in February 2004 and since then has made a number of investments in companies in medical devices, IT, consumer products, business products, specialty materials, Internet, aviation,etc. They believe they contribute more than money to the companies they fund and welcome the opportunity to work with entrepreneurs open to take advice, yet having the smarts and determination to make the company successful.Their focus is on early stage companies usually looking to raise $250K to $1.5M, where they can fund a portion of the round and syndicate the deal with other angel groups or early stage venture funds. The stage of the company should be close to commercialization, while the company should have a clear and defensible competitive advantage. They are looking for capital efficient businesses, which can reach profitability with less than $5M of equity investment and provide at least 10X return on the investment within 5 years.They do not invest as a fund - each of their members makes his or her individual investment decision but they collaborate in Due Diligence. They have a deep expertise in the life sciences field where they usually take the position of a lead investor, but are open to any opportunities that can make a strong business case. In some cases they prefer to be the follow on investor if they cannot identify a person with strong expertise within their group.The groupâ€™s strategy is directed by an executive committee which consists of 8 people elected by the group: Wayne Griffith (chairman), Bill McPhee, Henry Kay, Jay Schwartz (membership director), Steve Andress, Peter Miller, Don Freeman and Mic Williams (president and founder). The groupâ€™s day-to-day operations are managed by Boris Batchvarov (managing director).They receive 20-30 business summaries each month, out of which they select 8 companies to make a personal presentation to their screening committee. The screening committee consists of volunteers from the group. The presentations are 10 min long followed by 10 min Q&A. 4 of the companies are invited to present to the whole group, with the idea to get the people interested and decide to perform a Due Diligence with the companies before making an investment.

Investment focus

Biotechnology, Health Care, Medical Device
Angel, Seed, Series A
United States, Canada, India

Portfolio highlights

Zylö Therapeutics — Patented technology that enables, for topicals, sustained release, increased druggability, a Patchless Patch concept, and enhanced targeting of pores and follicles
Xeno Biosciences — Xeno Biosciences operates as a biopharmaceutical company pioneering a novel class of therapeutics to address large unmet needs in metabolic diseases. Lead program, XEN-101, is a first-in-class, oral formulation designed to shift the gut microbiome to the weight-loss associated state induced by Roux-en-Y Gastric Bypass (RYGB) surgery.It wasfounded in 2015 and is headquartered in Somerville, Massachusetts.
Astrocyte Pharmaceuticals — Astrocyte Pharmaceuticals Inc. is a privately held drug development company dedicated to accelerating the recovery and well-being of brain injury patients. The company is committed to proving the neuroprotective benefits of selective astrocyte activation, and advancing breakthrough therapeutic agents for treating brain injury resulting from stroke,TBI, concussion, and neurodegenerative disorders such as Alzheimer’s disease.

Providing Flexible and Creative Financial Solutions to Middle Market Companies.

Investment focus

Biotechnology, Health Care, Medical
Debt Financing, Post-IPO Debt, Series B
United States, United Kingdom, Canada

Portfolio highlights

Amino — Amino's digital healthcare guidance platform provides a fast, easy way to find a doctor, book appointments, and access health benefits.
Headspace — Live a healthier, happier, more well-rested life in just a few minutes a day with the Headspace app.
Pearl Street Dental Management — Pearl Street Dental Management supports non-clinical operations. They provide centralized services such as human resources, payroll, accounting, bookkeeping, finance, lending, facilities management, and information technology services. They address inquiries through online applications, phone calls, and emails.

At Connecticut Innovations, we see venture capital the way you see your business. Like no one else. We invest in innovative biotech, IT, and other industries.

Investment focus

Health Care, Biotechnology, Software
Seed, Series A, Funding Round
United States, Israel, Canada

Portfolio highlights

Conduce Health — Conduce Health is a multi-specialty value-based care marketplace providing turnkey solutions for primary care organizations.
DeepLook Medical — Enhancing Medical Imaging with Revolutionary Software: DeepLook Medical envisions a future where data-driven imaging enables accurate, efficient, and personalized care across the entire treatment pathway.
Manifest Technologies — Manifest Technologies was founded by a group of leading experts in computational neuroimaging and psychiatry at Yale University's School of Medicine. Our goal is to transform therapeutic development, diagnosis and treatment for CNS disorders. The company is advancing the world's first AI-powered computational neuroimaging system that quantifies neural and symptom data to create and choose the right therapy for the right patient at the right time.

Foundational partners to ambitious founders at every stage of company-building.

Investment focus

Software, Health Care, Biotechnology
Series B, Series A, Series C
United States, India, China

Portfolio highlights

Anterior — Lead your plan into the future.
Twelve Labs — Twelve Labs helps developers make programs that can see, listen, and understand the world as we do by giving them the most powerful video search API
Amber Therapeutics — Developing intelligent bioelectrical therapies that can adapt, respond and learn from each person's individual physiology

Wavemaker Three-Sixty Health is the leading U.S. early-stage (Seed and following on at the Series A) venture capital fund focused 100% on healthcare. Launched in 2018, Wavemaker 360 invested into the most promising healthcare startups in North America, with LPs from every sector of the US healthcare system. We are SEEDING HEALTHCARE'STOMORROW. We invest in healthcare disruptors and entrepreneurs that see how the industry is transforming itself and want to make a big difference.

Investment focus

Health Care, Medical, Medical Device
Seed, Series A, Funding Round
United States, United Kingdom, Canada

Portfolio highlights

Elektra Health — Evidence-based menopause expertise & care because you deserve better
Marigold Health — Marigold Health is an anonymous social network where people with mental health and substance use conditions support each other.
Materna Medical — Materna Medical empowers women to protect and restore their pelvic health.

Oxford Bioscience Partners (OBP), established in 1992, is a venture capital firm that provides equity financing and management assistance to emerging, entrepreneurial-driven companies within the life sciences and healthcare sectors. While willing to consider an investment in a company at almost any stage, OBP primarily works with early-stagesituations. With approximately $1B of committed capital under management, OBP has invested in over 140 life science companies worldwide.

Investment focus

Health Care, Biotechnology, Pharmaceutical
Series B, Series C, Series A
United States, Germany, Switzerland

Portfolio highlights

Paperspace — Ceres, Inc. (Ceres) is an agricultural biotechnology company selling seeds to produce renewable biomass feedstocks. The Company’s large-scale commercial products are sweet sorghum varieties that can be used as a drop-in feedstock to extend the operating season of Brazilian sugarcane-to-ethanol mills. Its products include sweet sorghum, high biomasssorghum, switchgrass, miscanthus and row crops. Its energy crops can also be used for the production of second-generation biofuels and bio-based chemicals, including cellulosic ethanol, butanol, jet fuel, diesel-like molecules and gasoline-like molecules, from non-food biomass. Baseload utility scale electric power can also be generated from the biomass feedstocks grown from its seeds. Ceres has sold switchgrass and high biomass sorghum seeds in the United States under its Blade Energy Crops (Blade) brand. In January 2010, the Company incorporated a subsidiary, Ceres Sementes do Brasil Ltda.
CardioFocus — CardioFocus is a biotechnology company that focuses on the advancement of ablation treatments for cardiac disorders. The company specializes in providing electrophysiologists with innovative and effective tools that bring new levels of precision and control to the treatment of atrial fibrillation that focuses on developing, manufacturing, andinvestigating disposable fiber optic catheters for the visualization of the cardiac anatomy and the treatment of cardiac arrhythmias.CardioFocus was founded in 1990 and is headquartered in Marlborough, Massachusetts.
Yolia Health — Yolia Health developed The True Vision Treatment or TVT, the 'Invisalign' for the eyes. A non-invasive treatment to correct vision problems like presbyopia without surgery. TVT is self-administered by the patient in his or her own home. It employs a combination of customized contact lenses (TVT Contacts) and specially formulatedeye drops (TVT Eye Drops). After only 5 days of treatment with TVT patients are able to stop using the TVT Contacts, TVT Eye Drops and their reading glasses for up to 12 months at a time before re-treatment with TVT is needed. What is even greater than correcting for presbyopia non-invasively, is correcting both eyes without compromising any distance vision. On the contrary, Yolia's treatment improves both near and distance vision, a unique feature no single other alternative can provide. ** Looking for sophisticated investors and key industry partners.

U.S. Venture Partners (USVP) is a venture capital partnership, helping entrepreneurs transform their ideas and efforts into world-changing companies. The firm focuses on early-stage ventures in information technology and health care, where innovation is unbridled and has led to the creation of economic wealth and millions of jobs over the pastthirty-plus years of the firm's existence. Areas of particular interest to our investment professionals include enterprise software, IT security, consumer internet, mobile, and e-commerce, healthcare, and IT-enabled healthcare services. The USVP team consists of former entrepreneurs, technologists, corporate executives, financial professionals, and industry domain experts.

Investment focus

Software, Health Care, Information Technology
Series B, Series C, Series A
United States, Israel, Canada

Portfolio highlights

IONIX — IONIX helps you secure your organization with our cutting-edge attack surface management solutions. Protect your digital assets and minimize risk exposure today.
Cagent Vascular — Cagent Vascular Inc. is a developer of next generation angioplasty balloons using Serration Technology for the treatment of cardiovascular disease.
Sparrow Pharmaceuticals — Sparrow Pharmaceuticals is an emerging clinical-stage biopharmaceutical company developing novel, targeted therapies for disorders of corticosteroid excess.

We’re (not just) investors.We’re (more than) advisors.We’re (beyond) connectors.Ben Franklin Technology Partners combines the best practices of early stage investing with a higher purpose – to lead the region’s technology community to new heights, creating jobs and transforming lives. For over 30 years, Ben has been the leading seedstage capital provider for the region’s technology sectors, investing over $170 million in more than 1,750 regional technology companies, many of which have gone on to become industry leaders. Ben Franklin has also launched university/industry partnerships that accelerate scientific discoveries to commercialization, and has seeded regional initiatives that strengthen our entrepreneurial community.

Investment focus

Health Care, Software, Information Technology
Seed, Grant, Debt Financing
United States

Portfolio highlights

GrowFlux — GrowFlux, Inc. they offers a ecosystem of commercial scale wireless lighting controls, cloud services, and cloud connected agricultural sensors.
SFA Therapeutics — SFA Therapeutics is a development-stage bio-pharmaceutical startup company focused on a new advancement in the treatment of chronic inflammatory disease - the use of microbiome-derived metabolites as drugs.
Avisi Technologies — Avisi Technologies is developing a nanotechnology-enabled defense against blindness from glaucoma.

Khosla Ventures invests in companies that are bold, early and impactful. The firm was started in 2004 by Vinod Khosla, co-founder of Sun Microsystems, to provide venture assistance to entrepreneurs. Headquartered in Menlo Park, Calif., Khosla Ventures invests in a range of areas including AI, climate, sustainability, enterprise, consumer, fintech,digital health, medtech and diagnostics, therapeutics and frontier technology.

Investment focus

Software, Health Care, Artificial Intelligence
Series A, Series B, Seed
United States, India, United Kingdom

Portfolio highlights

WindBorne Systems — WindBorne designs, builds, and operates a constellation of long-duration smart weather balloons targeting the most critical data in the atmosphere.
Honey Homes — Hassle-free Home Upkeep
Cartwheel — Cartwheel is a powerful text-to-animation platform. Animate characters for your video, game, movie, ad, Social or VR project simply by typing.

Horizon is a venture lending platform that offers structured debt products to life science and technology companies. Its team of investment and operations professionals has been providing debt capital to some of the most exciting companies for decades. The members of the Horizon team have, collectively, originated and invested more than $5 billionin venture loans to thousands of companies.The company was founded in 2003 and is headquartered in Farmington, Connecticut.

Investment focus

Health Care, Biotechnology, Medical Device
Debt Financing, Post-IPO Debt, Funding Round
United States, Canada, India

Portfolio highlights

Unagi Scooters — Unagi is an electric scooter startup that aims to liberate people from the tyranny of transportation frustrations—the costs, inconveniences, the carbon emissions. So we built the ideal personal liberation device.
Evelo Biosciences — Evelo Biosciences is dedicated to improving the lives of patients globally through the development of a new modality of medicines – monoclonal microbials. Monoclonal microbials are orally delivered medicines that modulate systemic immunology and biology through direct interactions with human cells in the gut. These new medicines are broadlyapplicable across many diseases – including autoimmune, immunoinflammatory, metabolic, neurological, neuroinflammatory diseases and cancer. Monoclonal microbials have the potential to fundamentally change traditional models of drug discovery and development. By finding and selecting naturally occurring monoclonal microbials with defined therapeutic effects, Evelo can improve the speed, cost and success of drug discovery and development. Evelo’s platform enables pharmacological intervention at all stages of disease with naturally occurring, safe and effective monoclonal microbials. Evelo Biosciences was conceived and created within VentureLabs®, Flagship Pioneering’s institutional innovation foundry, and launched by Flagship in 2015.
Viken Detection — Viken Detection is a research and technology development company focusing on X-ray physics and the design of analytical devices. The company's devices provide security imaging and material identification, which help to protect the public from terrorism and other dangerous dangers, allowing law enforcement and safety inspection agencies toremain vigilant and avoid drug trafficking.Viken was founded in 2013 and is headquartered in Newton, Massachusetts, United States.

Catalyst Health Ventures is an early-stage venture capital firm targeting technology solutions applied within the health care and life science industries. At the core of this strategy is a committed, hands-on approach to working with management and syndicate partners to build successful companies. Their disciplined investment process leverages bothintellectual and financial capital to originate deals, cultivate opportunities, and realize the full potential of emerging ventures in the health care and life science marketplace. We seek to invest in companies addressing major global unmet clinical needs in areas such as oncology, cardiovascular disease, obesity, and women’s health. We invest in pioneering and proprietary technological solutions fundamentally designed to reduce treatment costs and improve patient outcomes. By investing in solutions which have a technological foundation of engineering and development such as medical devices, diagnostic tools and instrumentation and consumer healthcare, we minimize the risks related to uncertain scientific experimentation.

Investment focus

Health Care, Medical Device, Medical
Series B, Series A, Series C
United States

Portfolio highlights

Rejoni — Learn about a clinical trial that is evaluating a new product which may prevent them.
Instylla — Instylla delivers next-generation liquid embolics for interventional radiology, with initial clinical applications in interventional oncology and peripheral hemostasis.
Brixton Biosciences — Brixton Biosciences is a biotechnology company currently operating in stealth mode.

Versant partners with exceptional entrepreneurs to build and fund breakthrough biotechnology companies around the globe.

Investment focus

Biotechnology, Health Care, Medical
Series A, Series B, Series C
United States, Switzerland, Canada

Portfolio highlights

Firefly Bio — Firefly specializes in Degrader Antibody Conjugates (DACs) which combine the unique strengths of ADCs with selective protein degraders.
SixPeaks Bio — SixPeaks is developing a pipeline of medicines for healthy weight loss.
Bright Peak Therapeutics — Bright Peak is a biotech company that develops a portfolio of immunotherapies for the treatment of cancer and autoimmune diseases. At Bright Peak, they are creating innovative cytokine therapeutics that are uniquely engineered to precisely control and expand desired biological properties.

Wisconsin Investment Partners is an Angel Investment Group in Madison, Wisconsin founded in 2000 with 20 members. Membership has grown to 50+ members in recent years, bringing significant knowledge and experience.

Investment focus

Health Care, Biotechnology, Medical
Funding Round, Seed, Series A
United States, Canada, United Kingdom

Portfolio highlights

Flyte — Flyte promotes cellular healing in pelvic floor muscles for lasting results. Flyte is fast, proven, safe, pelvic floor therapy for bladder control.
BeeReaders — ## Build Setup
Midwest Games — Midwest Games is a video game publisher focused on creating opportunities for the abundant talent across the Midwest and other underrepresented regions.

Delphi Ventures leverages years of experience, passion, & expertise to advance new technologies and build market leading biotechnology companies.

Investment focus

Health Care, Biotechnology, Medical Device
Series C, Series B, Series D
United States, Canada, Denmark

Portfolio highlights

MyShell — MyShell is a decentralized and comprehensive platform for discovering, creating, and staking AI-native apps.
Pixelmon — Collect, Evolve & Battle alongside your Pixelmon in our Multiplayer Open World Adventure and Monster Combat Arena.
Arrow Markets — The next generation of options markets. The Arrow protocol democratizes options trading through a hybrid RFQ system with on-chain exchange and settlement.

Canaan is an early stage venture capital firm that invests in entrepreneurs with visionary ideas. With $5B under management, a diversified fund and over 190 exits to date, Canaan has invested in some of the world's leading technology and healthcare companies over the past 30 years. Canaan’s focus areas include fintech, enterprise/cloud,marketplaces, frontier tech, biopharma, digital health, and medtech.

Investment focus

Software, Biotechnology, Health Care
Series A, Series B, Series C
United States, United Kingdom, Israel

Portfolio highlights

Aim Security — Aim is the industry guide to secure GenAI adoption, empowering security leaders to drive business productivity while ensuring proactive protection for all GenAI use cases.
Reibus — Reibus is the leading platform for buying and selling steel and other metals, with end-to-end services including logistics and financing.
Grey Wolf Therapeutics — By targeting the ERAP proteases in the antigen presentation pathway Grey Wolf aims to change the antigen repertoire in cancer.

For over two decades, Sand Hill Angels has worked openly and collaboratively with venture capital funds, other angel organizations, and the Bay Area ecosystem that fosters the growth of technology startups.

Investment focus

Health Care, Software, Biotechnology
Seed, Series B, Series A
United States, Canada, Japan

Portfolio highlights

Pulzaid — Platform for hybrid specialty care
GaeaStar — The zero waste clay cup. GaeaStar is an engineering company developing sustainable multiple use products and technology.
PrivacyHawk — PrivacyHawk is a Personal Data Protection service that makes opting out, unsubscribing, and deleting your data from thousands of companies easy.

Catalyst Health Ventures is an early-stage venture capital firm targeting technology solutions applied within the health care and life science industries. At the core of this strategy is a committed, hands-on approach to working with management and syndicate partners to build successful companies. Their disciplined investment process leverages bothintellectual and financial capital to originate deals, cultivate opportunities, and realize the full potential of emerging ventures in the health care and life science marketplace. We seek to invest in companies addressing major global unmet clinical needs in areas such as oncology, cardiovascular disease, obesity, and women’s health. We invest in pioneering and proprietary technological solutions fundamentally designed to reduce treatment costs and improve patient outcomes. By investing in solutions which have a technological foundation of engineering and development such as medical devices, diagnostic tools and instrumentation and consumer healthcare, we minimize the risks related to uncertain scientific experimentation.

Investment focus

Health Care, Medical Device, Medical
Series A, Series B, Series C
United States

Portfolio highlights

Epitel — Epilog is an unobtrusive wearable seizure detection system that records long-term EEG, anywhere. It gives people living with epilepsy peace of mind with a much-needed tool to better understand and manage their seizures.
Avive Solutions — Check out Avive Solutions, the manufacturers of a brand new AED machine - portable defibrillator - that's FDA approved!
PanTher Therapeutics — PanTher Therapeutics is on a mission to revolutionize cancer care with a proprietary treatment platform designed to enhance therapeutic response with minimal side effects. PanTher’s highly adaptable platform empowers oncologists to treat patients with life-threatening cancer by unlocking a drug’s full potential through direct, sustained treatmentat the tumor site. This distinctive targeting capability uniquely positions PanTher to take on the deadliest and most difficult to treat cancers with a lead investigational candidate in pancreatic cancer.

Split Rock Partners invests in emerging healthcare, software and Internet services companies in the Upper Midwest and West Coast. They are an early-stage venture capital firm that was founded in June 2004 by the former healthcare and software investment teams of St. Paul Venture Capital (SPVC). The Split Rock team managed over $1 billion of venturecapital during our tenure at SPVC, and continues to manage the SPVC healthcare and software portfolio. In May of 2008, they raised $300 million in the second Split Rock Partners fund, the successor to their inaugural $275 million fund raised in April 2005.The Split Rock team believes that it takes great people to translate promising ideas into compelling businesses. They are grounded in a fundamental respect for entrepreneurs and the rare combination of elements required when pioneering new markets. They start by looking for entrepreneurs with the passion, vision, and skills to build leading companies. They then work with entrepreneurs collaboratively, building partnerships based on integrity and mutual respect. The Split Rock team complements management expertise with over 80 years of venture investing and entrepreneurial management experience. They are proud of the strong relationships they have built with talented entrepreneurs and co-investors throughout their history and look forward to building on that tradition.

Investment focus

Health Care, Medical Device, Medical
Series A, Series B, Series C
United States, France

Portfolio highlights

Gravia — More benefits. Fewer asterisks. We are a health benefits company on a mission to build a health plan that everyone can love.
EBR Systems — EBR aims for outstanding treatment of cardiac rhythm diseases with an innovative leadless therapy.
Gravie — More benefits. Fewer asterisks. We are a health benefits company on a mission to build a health plan that everyone can love.

The Houston Angel Network (HAN) is a nonprofit organization dedicated to developing the innovation ecosystem in Houston, Texas by supporting founders and startups with financial resources and mentorship.

Investment focus

Health Care, Software, Information Technology
Seed, Funding Round, Series A
United States, Canada, United Kingdom

Portfolio highlights

CaseCTRL — Schedule surgeries with ease using AI-powered surgical scheduling. Fewer canceled cases, conflicts, and misorders. More surgery and time for patients!
Materna Medical — Materna Medical empowers women to protect and restore their pelvic health.
Amplified Sciences — Providing innovative diagnostic tests that enable earlier detection, risk stratification and monitoring of challenging diseases.

Kleiner Perkins is an American venture capital firm headquartered on Sand Hill Road in Menlo Park in Silicon Valley.

Investment focus

Software, Health Care, Information Technology
Series B, Series A, Series C
United States, China, United Kingdom

Portfolio highlights

Fizz — Fizz, the student debit card that builds credit. Build your credit while you earn amazing rewards! No hidden fees, no credit check & no security deposit.
Browserbase — Browserbase is a comprehensive platform for developers to host, administer, and monitor headless browsers in the cloud.
CesiumAstro — CesiumAstro builds high-throughput, software-defined phased array communication payloads for airborne and in-orbit platforms.

Tech Coast Angels is the largest angel investor group in the United States, possessing more than 300 members in five networks in Los Angeles, Orange County, San Diego, Central Coast, and the Inland Empire. Its members provide funding and guidance to more early-stage, high-growth companies in Southern California than any other investment group.Members invest in companies in a wide range of industries, including the life sciences, biotech, IT, services, retail, Internet, financial, software, media, consumer products, and tech startups. TCA as a whole gives companies more than just capital; they also provide counsel, mentoring, and access to an extensive network of potential investors, customers, strategic partners, and management talent. Tech Coast Angels has been ranked by CB Insights to be among the Top 20 Angel Groups in the US; TCA was also ranked as #1 for Network Centrality, meaning we have more connections than anyone! If you are in the game-changing business, we are here to help.

Investment focus

Software, Health Care, Biotechnology
Seed, Convertible Note, Funding Round
United States, Canada

Portfolio highlights

Reglagene — Reglagene is a therapeutics company that leverages its expertise in the design and development of brain penetrant medicines to create breakthrough therapies for the safe and effective treatment of brain diseases.
RealSeq Biosciences — RealSeq Biosciences’ core expertise includes innovative proprietary technologies for bias-free small RNA/miRNA NGS library construction.
Trio Pharmaceuticals — Trio Pharmaceuticals is a cancer therapeutics company that develops dual-action drugs for immunogenic tumors. These drugs directly stop tumor growth and selectively stop immunosuppression in the tumor without targeting the current immune checkpoint pathways. The company was founded in 2018 and is headquartered in San Diego, California.

Gaingels is a leading venture investment syndicate in support of diversity, inclusive of the LGBTQIA+ community and allies in the venture capital space.

Investment focus

Software, Health Care, FinTech
Seed, Series A, Series B
United States, Canada, Mexico

Portfolio highlights

AfterHour — Join the best stock trading community with over $200M+ in verified positions from retail traders. Get trade signals, due diligence, and real-time alpha.
TestParty — TestParty is the most effective solution for organizations to achieve digital accessibility compliance in the WCAG for the ADA, EAA, Section 508, and more.
Tomato.ai — Tomato.ai helps call centers soften accents, neutralize accents, and convert accents

The St. Louis Arch Angels is a network of accredited investors who fund early-stage businesses across the St. Louis region.

Investment focus

Biotechnology, Health Care, Software
Seed, Series A, Funding Round
United States, Argentina

Portfolio highlights

Peptyde Bio — Peptyde Bio is an Agtech startup positioned to become the go-to supplier of new AMPs.
SentiAR — SentiAR is digital health, software device company adding a new dimension to clinical practice in interventional procedures. Spun out of Washington University, we are developing the first 3D visualization platform using real-time holography of the patient's anatomy and catheter location, "floating" over the patients, with a goal toprovide the clinician and patient a faster, safer delivery of care.SentiAR’s mission is to transform the experience for both patient and clinician in interventional procedures with a 3D augmented reality platform featuring real-time holographic visualization of the patient’s actual anatomy, “floating” over the patient.The visualization is fully controllable “hands-free” by the clinician, providing an ergonomic breakthrough for the treatment and analysis of cardiac arrhythmias within an interventional catheter lab environment. SentiAR is developing the platform for eventual FDA submission.
Impetus Agriculture — Impetus Agriculture focuses on developing multiple topical or transgenic insect control products. Products that are safe, effective, and sustainable. Products that are not subject to the same insect resistance that has developed in current commercial products.

Silicon Valley Bank is the financial partner of the innovation economy; helping individuals and investors in the innovation ecosystem achieve extraordinary outcomes.

Investment focus

Software, Health Care, Biotechnology
Debt Financing, Series B, Series A
United States, United Kingdom, Canada

Portfolio highlights

Denim — Denim is an all-in-one financial enablement platform for the logistics industry. We work with brokerages to offer freight factoring and back office automation.
Harness — Harness is a self-service CI/CD platform that allows engineers and DevOps to build, test, deploy, and verify software, on-demand.
Parafin — Parafin provides you with an end-to-end solution to offer one-click financing to your sellers.

Rev1 Ventures provides seed stage venture capital funding in Columbus, Ohio along with startup services, space, mentoring, and connections. Learn more!

Investment focus

Software, Health Care, Information Technology
Seed, Series A, Funding Round
United States, Germany

Portfolio highlights

Trace — Trace is the simplest way ever to create AR content and experiences for your product and business.
Champ — Through the application of its secure, patent-pending technology, CHAMPtitles ends the reliance on legacy systems to manage U.S. automobile titles. CHAMPtitles partners with each party in the vehicle title ecosystem to reduce their costs in handling titles, turning the burdensome administrative process of issuing a vehicle title into a profitableactivity.
Niobium Microsystems — Niobium Microsystems creates custom integrated circuit and microelectronic system solutions for clients with complex power, performance, and security constraints.

DeNovo Ventures was formed in 2000 by seasoned investors and experienced medical device entrepreneurs who sought to share the lessons learned from a history of successful investing and building successful companies. They believed that their unique combination of skills and perspectives could help entrepreneurs to build companies which would havesignificant clinical impact and generate superior returns. Seven years later, this belief continues to hold true, demonstrated by investment success in selected medical device and biotechnology companies. With $650 million under management, De Novo has made more than 40 investments in medical devices and biotechnology across three funds. They invest in all stages of enterprise development and growth â€“ from early stage to late stage. The unique background of leading companies as entrepreneurs and operating executives from start to exit enables us to advise entrepreneurs and management teams over the full life cycle of the company.

Investment focus

Health Care, Medical Device, Biotechnology
Series B, Series D, Series C
United States

Portfolio highlights

Avedro — Glaukos works relentlessly to create and deliver transformative therapies for patients struggling with glaucoma, corneal disorders, and retinal diseases.
Milo — Milo is a group action communicator, sophisticated wireless networking, audio processing & powerful hardware in a carefully crafted design.
Spinal Kinetics — The artificial disc replacement device from Orthofix is changing the lives of people suffering from spinal pain. Learn about this motion-saving product.

ShangBay Capital is a venture capital company that brings best-in-class investments mainly in the U.S. medical devices technology, as well as biotech, and mobile healthcare sectors through early-stage venture equity participation

Investment focus

Health Care, Medical Device, Biotechnology
Series A, Series B, Series C
United States, China, Canada

Portfolio highlights

Luminopia — Luminopia is the first FDA-approved binocular therapy for amblyopia.
Avation Medical — Avation Medical is an innovative advanced neuromodulation & digital health company pioneering wearable neuromodulation therapies.
Laplace Interventional — Laplace developing Transcatheter Tricuspid Valve Technology to offer an increase in life expectancy and an improvement to the quality of life to worldwide patients with tricuspid regurgitation.

Three Arch Partners was formed in 1993 to provide young companies with access to relevant clinical and business resources, as well as capital. Three Arch has helped create, build and fund more than 100 important new healthcare companies. These companies have often become the clinical and market leaders in their respective fields, and have generatedstrong returns. The fund focuses on opportunities in medical devices and healthcare services, and less frequently in biotechnology.

Investment focus

Health Care, Biotechnology, Medical Device
Series B, Series C, Funding Round
United States, Belgium

Portfolio highlights

Nevro — We Believe True Innovation Transforms More Lives
Neuronetics — Antidepressant medications don't work for everyone. If drugs haven't worked for you, learn about NeuroStar - safe, effective, lasting TMS therapy for depression.
Access Closure — Access Closure, Inc., a medical device company, provides access site management products to address the complex challenge of vascular closure during interventional and diagnostic procedures. The company's products include Mynx delivery system, a vascular closure device that seals the arteriotomy using a water-soluble and extravascular sealant,which expands in the tissue tract by absorbing blood and subcutaneous fluids. Access Closure, Inc. was founded in 2002 and is based in Mountain View, California.

Virginia Venture Partners is a family of seed-stage investment funds placing near-equity and equity investments in Virginia-based technology, life science, and cleantech companies. Virginia Venture Partners invests in companies with a high potential for achieving rapid growth and generating significant economic returns for entrepreneurs,co-investors, and the Commonwealth of Virginia. CIT’s family of funds includes:GAP Fund I is a vintage 2004 fund fully invested in a broad array of seed-stage technology companies. Portfolio.GAP BioLife Fund is a seed fund investing exclusively in life science companies.GAP Tech Fund is a seed fund investing in IT and technology companies.

Investment focus

Software, Health Care, SaaS
Seed, Funding Round, Series A
United States, Canada, France

Portfolio highlights

CarpeDM — CarpeDM app is an exclusive member-only dating community created for singles seeking meaningful relationships with professional Black women.
WRANGLD — WRANGLD operates as a SaaS company that provides a platform for the trades and service industries.
Bricklayer.ai — Bricklayer AI is the first automated AI security team. Run better, faster, more efficient security operations with AI agents alongside humans.

Third Rock Ventures is a leading healthcare venture firm focused on advancing disruptive areas of science and medicine to deliver breakthroughs to patients.

Investment focus

Biotechnology, Health Care, Therapeutics
Series A, Series B, Series C
United States

Portfolio highlights

Marea Therapeutics — Marea Therapeutics is a clinical-stage biotechnology firm that uses the most recent advancements in human genetics to create first-in-class, next-generation medications for cardiometabolic illnesses.
Seaport Therapeutics — Seaport Therapeutics operates as a clinical stage biopharmaceutical company.
Synnovation Therapeutics — Synnovation Therapeutics is a precision oncology company focused on small molecule therapies optimized to target key driver mechanisms in cancers. It is dedicated to the discovery and development of therapeutics that can improve the lives of people with cancer. Leveraging its deep expertise in medicinal chemistry, cancer biology, andpatient-focused precision medicine, it builds a diverse pipeline of novel small-molecule targeted therapies. It aims to efficiently advance these agents into clinical trials with the goal of transforming cancer patient care.

Life Science Angels, Inc. (LSA) is the premier angel investment group focused solely on healthcare investing, including medical devices, diagnostics, pharmaceuticals, biotechnology, and digital health.

Investment focus

Biotechnology, Health Care, Medical
Funding Round, Seed, Series A
United States, Israel, The Netherlands

Portfolio highlights

InnoSIGN — We are passionate to bring to market our OncoSIGNal pathway activity profiling technology contributing to a better understanding of disease mechanisms in oncology. OncoSIGNal enables next generation precision medicine by translating molecular data into functional cell behavior.
Allyx Therapeutics — Allyx Therapeutics is a clinical-stage biotechnology company that develops therapies designed to reverse neurodegeneration. Allyx Therapeutics' product is an orally bioavailable small molecule that acts as a silent allosteric modulator, enabling clinicians to get a drug that is capable of delivering a disease-modifying approach and preservecognition in patients.
Avisi Technologies — Avisi Technologies is developing a nanotechnology-enabled defense against blindness from glaucoma.

Keiretsu Capital LLC is an affiliate of the World's Leading Angel Network, Keiretsu Forum, and manages funds which enable limited partners to co-invest in the proprietary deal flow of the angel investors.

Investment focus

Health Care, Biotechnology, Medical
Funding Round, Series A, Seed
United States, Canada, India

Portfolio highlights

Clensta — Clensta is a biotechnology start-up to improve the National Hygiene condition whilst addressing the aspect of water conservation. Clensta is an Indian startup and in association with IIT Delhi, works to create innovative healthcare solutions to make hygiene accessible for anyone, anytime, and anywhere. Driven by their aim to create products thatpromote complete cleaning solutions without water.
Healionics — Healionics has applied its expertise in synthetic biomaterials to develop a novel vascular graft (artificial blood vessel) that, unlike existing grafts, remains open to blood flow long-term without need for costly interventions. Its first commercial application will be as a more reliable means of vascular access for dialysis patients, with asubsequent application to treat peripheral artery disease. We have great results in multiple controlled animal studies, a large patent portfolio, established production capacity, and are ready to begin human studies later this year in preparation for market launch.Near-Term Problem / Market Opportunity: Vascular Access for Dialysis Kidney failure patients need to have their blood filtered 3 times per week via dialysis. This removes waste from the blood, which would otherwise cause them to die. However, current methods for repeatedly accessing the bloodstream for dialysis are unreliable. This problem is a huge contributor to the $50 billion per year that the U.S. spends on dialysis patients (7% of Medicare’s entire budget!). A vascular graft is often implanted under the skin (connecting an artery to a vein) to create an access site with sufficient bloodflow for dialysis -- but existing grafts tend to occlude quickly, requiring repeated expensive interventions to keep them open.Solution: STARgraft Because our vascular graft remains open to blood flow much longer than existing grafts, it can potentially satisfy a severe unmet clinical need for ready-to-use, safe, long-term dialysis access, while substantially reducing costs, illness and death rate among dialysis patients.Product Pipeline We have additional products in development, including an implantable port which will allow needle-free dialysis. Eliminating the use of needles would further reduce cost and illness among dialysis patients, and allow them to perform dialysis in the convenience of their own home. In addition, our platform STAR biomaterial can improve the performance of a wide range of implantable devices via its remarkable ability to prevent both infection and scar tissue. We currently have two corporate-funded development contracts to explore STAR material’s use in multiple other device applications.
Another Tomorrow — Conscious Clothing. Education. Action. Another Tomorrow pushes the boundaries of what responsibly grown, and ethically manufactured materials can achieve. Sensual and strong, our collection is designed for living.

Privately Held Companies

Investment focus

Health Care, Biotechnology, Medical
Series A, Series B, Series C
United States, Canada, New Zealand

Portfolio highlights

BeeKeeperAI — BeeKeeperAI is a zero trust collaboration platform protecting both algorithm IP and regulated data.
Solu Therapeutics — Solu Therapeutics is a precision-medicine-focused company developing therapeutics to eliminate disease-driving cells.
Reprieve Cardiovascular — Reprieve Cardiovascular is bringing intelligence to decongestion management to safely accelerate fluid removal for heart failure patients.

Green Park & Golf, built on over 50 years of operational and financial experience, seeks investment opportunities that offer above-market returns for its investors. Led by Clay Heighten, M.D., and Carl Soderstrom, the Firm delivers strategic solutions, financial backing and a reliable network to its portfolio companies. The Dallas-based Firm iscurrently looking for investment opportunities in medical-related start-ups.Dr. Heighten founded MedicalEdge Healthcare Group in 1993, and Mr. Soderstrom started PhyServe Physician Services in 1998 to administer the financial and operational needs of MedicalEdge. Together, the companies managed over 550 providers in five major markets. In 2011, the companies were sold to Texas Health Resources, a $3.8 billion health care system. That’s when Green Park & Golf was born.After earning his MBA at Southern Methodist University, Mr. Garcia joined them full-time in May 2011 to actively pursue new investment opportunities and monitor other investments in their portfolio. He has prior professional experience at FedEx, Bold Ventures, and Lone Star Investment Advisors.

Investment focus

Health Care, Medical, Biotechnology
Series A, Seed, Series B
United States, Israel, Sweden

Portfolio highlights

Validic — Uncover healthcare trends and personalized care advancements. Learn how technology transforms patient outcomes and manages chronic conditions effectively.
Prolocor — Our goal is to develop a more precise method and diagnostic tool for assessing and managing risk in cardiovascular disease.
Worlds — Worlds is completely re-inventing how organizations see and understand their worlds. Through live, AI-powered models, the company’s clients can remotely see, learn and analyze their worlds in ways that were never possible before.

Morgenthaler Ventures has been in the venture capital business for more than 45 years, steadily investing through every market cycle. Select past and present portfolio companies in the IT space include: Evernote, Lending Club, Siri, MuleSoft, Practice Fusion, Adara Media, Check, Doximity, PeopleMatter, Socrata, NuoDB, Jaspersoft, VoltageSecurity, Rhythm NewMedia, Nominum, Wize Commerce (NexTag) and back in the day, Apple.

Investment focus

Health Care, Biotechnology, Medical
Series B, Series A, Funding Round
United States, Canada, France

Portfolio highlights

Moximed — Moximed Inc. is dedicated to improving the standard of care for patients with osteoarthritis, and is investigating therapies to treat a number of affected joints. The lead product, the KineSpring® Knee Implant System, is designed for patients with knee osteoarthritis.
SetPoint Medical — SetPoint Medical is pioneering bioelectronic medicine to develop a safe and cost-effective approach for treatment of chronic autoimmune diseases.
Relievant Medsystems — Relievant's mission is to provide patients with low risk therapy that can alleviate their back pain.

Keiretsu Forum is a global angel investor network with more than 2,500 accredited investor members throughout 47 chapters on 3 continents.

Investment focus

Health Care, Software, Biotechnology
Funding Round, Seed, Series A
United States, India, Turkey

Portfolio highlights

MangoPoint — MangoPoint provides a sustainable, integrated value chain for mangoes with single-origin, carbide-free, chemical-free high-quality fresh mangoes, and processed mango products through sustainable farming, planet-friendly processing, and eco-friendly packaging.
Qube Health — QubeHealth simplifies Employee Healthcare Benefits management for the Biggest Companies in India
AutoNxt Automation — Discover the future of sustainable farming with Autonxt Automations electric tractors and self-driving technology. Explore our innovative solutions today.

Invest Nebraska builds a better future for our state by providing financial and operational assistance to high growth companies, advancing the entrepreneurial economy, and attracting out-of-state capital to Nebraska.

Investment focus

Software, Health Care, Information Technology
Pre-Seed, Seed, Debt Financing
United States

Portfolio highlights

Maptician — Struggling with managing your hybrid office? Maptician Office Hoteling Software is the easy solution to create an office your employees will love.
MicroWash — MicroWash is the first nasal lavage specimen collection device that delivers a comfortable, fast and high-quality sample, surpassing the nasal swab.
Corral Technologies — Corral Technologies offers an easy to use virtual fence system. Allowing ranchers to move, track, and analyze every single cow at the touch of a button.