Top 50 Blockchain Startup Investors in United States (October 2026)

Portfolio highlights

• Raven — Raven is a proprietary high-frequency algorithmic trading firm specializing in CeFi market making and DeFi liquidity provision.
• Jeeves Inc. — Pay for anything, anywhere, in your local currency. No fees. No interest. No personal guarantees. Mobile-first, built with your team in mind.
• Catchback Cards — Catchback Cards offers a platform for buying, selling, storing, and auctioning collectibles with pack opening and card-backed loan services.

Portfolio highlights

• Orthogonal — Giving AI agents the tools they need.
• World Foundation — World is the real human network. A new standard of trust on the internet.
• Solana Company — Building the Preeminent Solana Treasury $HSDT

Portfolio highlights

• Yellow Card — Yellow Card is a licensed stablecoin payments infrastructure provider powering global money movement across USD and 50+ local currencies. Talk to us.
• Blueprint Finance — Blueprint Finance develops protocols and infrastructure to advance on-chain financing.
• M0 —

Portfolio highlights

• TurboFlow — Trading, made simple. Everyone gets a seat at TurboFlow.
• DePay — DePay is an Argentina-based real-time payments infrastructure startup.
• Limited — Secure your treasury and scale your business globally with a truly self-custodial account that only you control. No banks. No middlemen.

Portfolio highlights

• NG.CASH — NG.CASH is a digital bank designed to help the new generations (ages 12 to 30) achieve financial independence. It lets users take charge of their money through solutions like PIX (Brazil’s instant-payment system), prepaid and virtual cards, allowance management, and now credit products tailored for young adults. As a financial hub, NG.CASH is builtto grow with its clients, boosting financial literacy and supporting them at every stage of life.
• TRM Labs — Next Generation Blockchain Intelligence | Monitor, Investigate, and Mitigate Crypto Fraud and Financial Crime
• Tare — Tare uses AI and tokenization to change the entire credit lifecycle.

Portfolio highlights

• Particle — Afternic is a one-stop site to buy, sell and park domains. See for your self why Afternic is the world's premiere domain marketplace and exchange reseller.
• Akiba Digital — Akiba Digital is a data and technology company that provides financial intelligence solutions. Our vision is to to unlock financial opportunities for consumers, businesses and society using alternative data.
• Enact — Enact is a leading solar energy and solar software company serving homeowners, businesses, and installers. Get a free quote or request a demo today!

Portfolio highlights

• Zcash — Zcash offers total payment confidentiality, while still maintaining a decentralized network using a public blockchain. Unlike Bitcoin, Zcash transactions automatically hide the sender, recipient, and value of all transactions on the blockchain. Only those with the correct view key can see the contents. Users have complete control and can opt-in toprovide others with their view key at their discretion.Zcash transactions do not depend on the cooperation of other parties. Additionally, full nodes in the Zcash network only need to store a small persistent state.
• Grass — Affiliated with @grass
• Trasia Labs — Trasia is an Asia-first trading platform built on @HyperliquidX. Mobile app will be live soon. Trade Asia with Trasia.

Portfolio highlights

• Jeeves Inc. — Pay for anything, anywhere, in your local currency. No fees. No interest. No personal guarantees. Mobile-first, built with your team in mind.
• EDGE Markets — The Financial Platform for Smart Bettors
• LI.FI — Advanced Bridge & DEX Aggregation - Drive multichain strategies with cross-chain data messaging and get users from everywhere.

Portfolio highlights

• Superlogic — OneOf is the mass-consumer Web3 company connecting the next 100M non-crypto-native fans to iconic brands, artists, and athletes. OneOf technology enables global brands and enterprises to reimagine commerce, loyalty and engagement, allowing consumers to seamlessly collect or trade digital assets with no prior crypto expertise. Deeply committed to a sustainable and inclusive blockchain future, minting digital assets on OneOf's platform uses up to 2 million times less energy than previous generation proof-of-work networks, and costs up to 99% less in gas fees. A leader in diversity, over 80% of the collections curated by OneOf come from minority or female creators.
• PERPTools — PERPTools combines crypto perpetual trading with activity points and risk-free market predictions.
• Slinky Network — Slinky Network provides an on-chain marketplace and payment protocol that connects AI agents and applications with third-party APIs. The company offers the SlinkyLayer platform, which wraps developer endpoints as discoverable skills and exposes them through an x402 pay-per-execution interface. Each API call triggers a non-custodial on-chainmicropayment, settling in the same request loop using networks such as Base and BNB Chain. Developers set prices, earn a defined revenue share, and receive instant payouts to their wallets without subscriptions or custodial holds. AI agents authenticate via wallet signatures, enabling autonomous, machine-to-machine access and payment without traditional logins or credit cards. The platform also records call ratings on-chain to provide portable, verifiable reputation for services.

Portfolio highlights

• Squads — Collaborative infrastructure for web3 native teams
• Nova Markets — Decide what lists next on @HyperliquidX and earn from every listing, forever.
• Physical Superintelligence — Physical Superintelligence develops physical superintelligence systems that use AI-driven research to study physics, engineer physical systems, and explore new physical laws. Its approach combines human scientists with virtual physicists that conduct autonomous research campaigns covering hypothesis development, verification, experimentation,engineering, and deployment. The company focuses initially on the physical infrastructure underlying AI, including energy, materials, computation, sensing, and manufacturing.

Portfolio highlights

• Kapkap — Kapkap is a web3 platform that uses AI for attention based value distribution in gaming.
• PERPTools — PERPTools combines crypto perpetual trading with activity points and risk-free market predictions.
• Open Campus — The Open Campus is a community-driven protocol that leverages the power of blockchain and invites all to build the future of education by putting the power of learning back in the hands of educators, students, and the community.

Portfolio highlights

• Axis Robotics — AXIS ROBOTICS | Transferring Diverse Human Intelligence Into Robotic General Intelligence
• Hyperlane — Hyperlane is the platform for developers building the interchain universe
• Silicon Data — Revolutionize compute markets through unparalleled data transparency, financial product innovation and market intelligence

Portfolio highlights

• V12 — Tune V12 to your codebase. Investigate security findings with the source, a reproducible proof, and a concrete fix.
• InfiniFi — backup infiniFi account. Main infiniFi account - @infiniFi
• Legend. trade — Where traders become Legends.

Portfolio highlights

• DePay — DePay is an Argentina-based real-time payments infrastructure startup.
• Diameter Pay — Diameter Pay is a financial service company that provides financial inclusion, fintech, blockchain, and social entrepreneurship services.
• City Protocol — City Protocol offers growth incentives and creative tools driven by AI. A portable reputation is created via City ID.

Portfolio highlights

• Crown — Crown issues BRLV, a real-backed stablecoin pegged to the Brazilian real, designed to maximize security and liquidity while ensuring compliance with institutional-grade regulations.
• Harmonic — Harmonic is a block building system to increase validator rewards.
• Global Token Exchange — Global Token Exchange is an end-to-end decentralized trading platform with CEX-level performance.

Portfolio highlights

• Tennr — Tennr is a custom AI assistant that accelerates research, answers complex questions, and generates custom reports.
• Phota Labs — Phota Labs is a developer of personalized AI photography tools preserving identity and memories.
• Supersonik — Supersonik provides an AI-powered platform for SaaS companies to offer 24/7 interactive product demos, enabling prospects to explore and personalize demos instantly without scheduling or manual intervention.

Portfolio highlights

• Portal to Bitcoin — The only custody-less interoperability protocol for Bitcoin. Swap native BTC, Ordinals, Runes with L2s and L1s
• ether.fi — EtherFi is a non-custodial decentralized ETH staking method that distributes staking to node operators in exchange for rewards.
• Azuro — Powerful tooling, oracle & liquidity solutions for any EVM predictions & gaming ecosystem

Portfolio highlights

• 3Commas — 3Commas develops a crypto-asset management tool for tracking investments and exchanges in a unified platform. It provides access to a unified dashboard as the central hub for trading and portfolio management execution.
• Fuel Labs — At Fuel, we are building the fastest execution layer for the modular blockchain stack.
• Optim Finance — Optim Finance provides investment tools that optimize yield on digital assets. Their financial primitives enable users to rent ADA delegation rights to power novel use cases such as SPO loans, leverage into ISOs, and initial bonds.

Portfolio highlights

• Hyperpublic — Hyperpublic is an open database of people, places, and things tied to a specific location. Anyone can add objects to the database and developers will be able to build applications on top of the data.
• Flow Engineering — Flow Engineering develops AI-powered systems engineering software for requirements management, validation, and hardware design workflows.
• Proximal — Proximal builds AI training data and environments to improve software engineering agents and autonomous coding systems.

Portfolio highlights

• Sapiom — The platform vertical AI companies build, ship, and scale agentic products.
• City Protocol — City Protocol offers growth incentives and creative tools driven by AI. A portable reputation is created via City ID.
• Velocity — Velocity provides a unified platform for efficiently moving and managing funds across both traditional banks and blockchains.

Portfolio highlights

• ME Group — MetaEra is a one-stop resource aggregator for Web3.0. Meta Era focuses on blockchain and metaverse exploration, pursuing professional, thorough, and reliable information and data.
• Canopy Network — AI creates apps. Canopy creates owners. Build and launch in days. Backed by @Arrington_Cap, @Fenbushi, @Borderless_Cap, @SNZHolding, @CodecraftGroup and more.
• Chronicle Labs — Chronicle Protocol brings data onchain via decentralized, cost-efficient, verifiable oracles, powering DeFi and RWAs with DeFi and Proof of Asset Oracles.

Portfolio highlights

• Oh — The OpenAI of the spicy content industry, combining consumer platforms (@ohchatai | @ohdotfun) with infrastructure (https://t.co/BMwDSzAg14)
• Chance Studios — Every Collection Starts With A Chance
• Chance Studios — Every Collection Starts With A Chance

Portfolio highlights

• Vorflux — Cloud agents that ship production code. An opinionated harness that runs the full SDLC on dedicated machines.
• Dirac Labs — Universal Navigation Powered by Quantum Sensing & AI
• Physical Superintelligence — Physical Superintelligence develops physical superintelligence systems that use AI-driven research to study physics, engineer physical systems, and explore new physical laws. Its approach combines human scientists with virtual physicists that conduct autonomous research campaigns covering hypothesis development, verification, experimentation,engineering, and deployment. The company focuses initially on the physical infrastructure underlying AI, including energy, materials, computation, sensing, and manufacturing.

Portfolio highlights

• Fence — At Fence, we're transforming the way debt facilities are managed. We are the Operating System for your debt facility, reducing the amount of resources spent in back-office operations and letting teams focus on what matters.Our platform, built on blockchain technology, offers a Software as a Service (SaaS) solution that simplifies andautomate debt facility operations. Whether you're a capital provider or an asset originator, Fence leads you toward a smarter financial future.For capital providers, our platform enables internet-native debt solutions and real-time portfolio insights, enhancing your credit investment monitoring. With Fence, you stay ahead, making informed decisions for success. Asset originators benefit from enhanced capital efficiency and reduced operational costs, thanks to Fence's automation. We seamlessly integrate debt facilities into your tech stack and provide on-demand programmable debt, giving you unprecedented control over the capital you borrow.
• Jeeves Inc. — Pay for anything, anywhere, in your local currency. No fees. No interest. No personal guarantees. Mobile-first, built with your team in mind.
• Limited — Secure your treasury and scale your business globally with a truly self-custodial account that only you control. No banks. No middlemen.

Portfolio highlights

• Solana — Solana is the high performance network powering internet capital markets, payments, and crypto applications. Fast. Decentralized. Scalable. Energy efficient. Solana can power thousands of transactions per second.
• Flying Tulip — Better Yield, Better UX
• Hypernova — The onchain prop firm, built to back traders.

Portfolio highlights

• heXem bio — heXem bio specializes in recording solutions for the early development of humans for longevity.
• Cloverleaf Bio — Cloverleaf Bio | Developing a new class of RNA therapeutics to revolutionize cancer therapy.
• Poseidon Aerospace — Poseidon Aerospace is developing unmanned cargo aircraft for regional commercial air freight and contested defense logistics.

Portfolio highlights

• Tennr — Tennr is a custom AI assistant that accelerates research, answers complex questions, and generates custom reports.
• Whizzo — Whizzo specializes in materials science-driven manufacturing of engineered fashion and technical textiles. Our expertise lies in creating and executing innovative textile blends tailored for applications across automotive, agriculture, medical textiles, and engineered fashion.
• ElevenLabs — Create lifelike speech with our AI voice generator and voice agents platform. Access 5,000+ voices in 70+ languages with secure APIs and SDKs.

Portfolio highlights

• Wizzwoods — 1st pixel farm game integrates interchain capabilities with a SocialFi twist.
• SuperIntent — SuperIntent is a cryptocurrency AI app that streamlines on-chain earning tactics. Developed on a multi-agent framework with abundant yield sources.
• SuperGaming — At SuperGaming, we are putting India on the global gaming map.

Portfolio highlights

• Rilla — Demonstrating 90% reduction in cost-to-serve for live-streaming, Rilla is rewiring the content economy, directing the value generated back to creators and their communities.By leveraging audience bandwidth and rewarding them with ownership in the network, the savings are equivalent to a free month subscription every year for a moderate level ofviewership.Founded by the technical founders behind Altered State Machine, acquired for 214m. Together for 5+ ventures, collectively raising 130m+ and valued at 1b+.
• Osmo — Osmo is a payment company that helps people to send and receive money immediately.
• Uniblock — Uniblock helps connect developers with Web3 using our APIs and services. Our developers use Uniblock because of how easy it is to integrate into exciting applications. Try it for free today!

Portfolio highlights

• Axis — A global liquidity provider for tokenized markets. Backed by @galaxyhq, @FalconXGlobal, @okx.
• Zoo Finance — Zoo Finance is a pioneering DeFi protocol focused on unlocking liquidity from locked assets, empowering users to access capital more efficiently while maximizing the utility of their on-chain holdings.
• Hypernova — The onchain prop firm, built to back traders.

Portfolio highlights

• Mecka AI — Mecka is the data and deployment layer for Physical AI.
• Spearbit — Spearbit connects independent security experts to Web3 projects that need them.The company offers a range of services, including expert-conducted security reviews and ongoing security reviews through retainer agreements. These services provide clients with an operational layer, freeing them from time-consuming administrative tasks and clientsourcing and due diligence.
• TVL Capital — TVL Capital is a financial infrastructure firm specialising in Chain Traded Products (CTPs).

Portfolio highlights

• Soter Insure — Reliable insurance for the digital asset ecosystem.
• Ethereum Institutional — Accelerating institutional adoption of Ethereum
• Digital Prime Technologies — Full-Service Institutional-Grade Prime Brokerage for Digital Asset Management. DLCC offers full-service Prime Brokerage solutions for digital assets. Our all-in-one user interface leverages both API and Saas product offerings to connect clients with a growing network of liquidity providers to transact, borrow, and lend digital assets, and managecollateral. Our product suite also offers traditional Prime Brokerage services, such as consultation and capital introduction.

Portfolio highlights

• Cyclops.io — Cyclops is the only crypto and stablecoin platform exclusively for payments companies. Cyclops enables payment service providers to accept crypto, do stablecoin settlement, and manage digital assets with enterprise-grade security. We provide PSPs, Card Networks, Acquirers, PayFacs and otherws with compliant crypto solutions without building in-house. Cyclops is chain agnostic, supporting Bitcoin, Ethereum, USDC, USDT, and multi-chain stablecoin settlement. White-label and turnkey offerings.
• Félix — Félix is ​​a chat-based platform that enables Latinos in the US to send money abroad. We combine Blockchain and Artificial Intelligence to disrupt how remittances are done today and build the future of cross-border payments.
• Birdai Labs — Birdai operates at the base of the chain, measures where value leaks between an order and its fill, and is built to return it to the people who create the order flow.

Portfolio highlights

• PERPTools — PERPTools combines crypto perpetual trading with activity points and risk-free market predictions.
• Chomp — Chomp is a social network platform that focuses on on question-and-answer with prediction-based systems.
• Solana Company — Building the Preeminent Solana Treasury $HSDT

Portfolio highlights

• Solana — Solana is the high performance network powering internet capital markets, payments, and crypto applications. Fast. Decentralized. Scalable. Energy efficient. Solana can power thousands of transactions per second.
• Saturn — Onchain Structured Digital Credit | Disciples of @Saylor | Incubated by @YZiLabs | Backed by @AD_VenturesX @SoraVentures @TheSpartanGroup
• THEA-AI — AI that amplifies human performance

Portfolio highlights

• Bio.xyz — Biotech's new financial layer.
• Recall Labs — Textile is building new digital experiences by focusing on user privacy, transparency, and decentralization.
• Blackbird — We believe the next great hospitality technology platform should connect restaurants and their customers directly, in meaningful and ongoing ways. Blackbird is founded by a team with a passion for restaurants and a track record of using technology to solve problems.

Portfolio highlights

• Ornn AI, Inc — The Compute Market
• Circle — Circle helps businesses and developers harness the power of digital dollar stablecoins for payments and internet commerce worldwide. Learn more today!
• Catena Labs — Catena is a product studio where we transform complex computing advancements into accessible, practical tools for users and developers. Leveraging AI and web3 technology our aim is to turn innovative ideas into real-world applications that are easy to use.

Portfolio highlights

• IOTrader — Decentralized Trading Platform,Precision Futures Trading Built for Modern Traders Trade crypto, forex, commodities and more with low fees,
• Tomoland — Tomoland is a social gaming platform where users create avatars, worlds, and multiplayer experiences.
• Midas — Structured Products, Onchain.

Portfolio highlights

• AltLayer — AltLayer is a system of highly scalable application-dedicated execution layers that derive security from an underlying L1/L2.
• Supra — Supra is the world's highest-performing, fully vertically integrated L1 blockchain, and it's about to change everything.
• Panoptic — The Panoptic protocol enables the minting, trading, and market-making of perpetual put and call options.

Portfolio highlights

• AKEDO — The vibe coding Content Creation Engine and Launchpad Backed by @Karatage_, @Sfermion_, @Collab_Currency https://t.co/PA0vYr1Oeo
• TON Strategy Company — VERB Technology Company is a software-as-a-Service, or SaaS, applications platform developer. Its platform is comprised of sales enablement business software products marketed on a subscription basis. The applications are available in both mobile and desktop versions. It includes verbCRM, Customer Relationship Management application, verbLEARN,Learning Management System application, and verbLIVE, its Live Broadcast Video Webinar application.
• Fundamental Global — FG Nexus is building a U.S. public company dedicated to Ethereum accumulation and on-chain yield generation, a capital markets vehicle engineered for one of the most important digital assets of this era.

Portfolio highlights

• BetHog — BetHog is a new crypto sports book that brings home the bacon.
• Trove — Trove Collectibles is a content and commerce platform focused on sports cards and collectibles.
• Kairos Labs — Kairos Labs is an Ethereum ecosystem interest rate swap protocol

Portfolio highlights

• tbh — tbh is a developer of a mobile application designed to provide anonymous feedback to friends. The company's mobile application facilitates asking or answering questions, open text fields and invite abuse when combined with anonymity, enabling users to say things without repercussions and feel better about themselves from the positive feedbackon social networks.
• Vidrovr — Vidrovr develops multimodal computer vision and machine learning systems to index, tag, and understand video. It processes videos with specific domain constraints, such as in sports, government, and media verticals. Its technology enables its users to search an indexed video corpus and retrieve content inside videos and link it to other media likephotos and text.The company Integrates social media to enable direct interactions between multimedia content. Vidrovr was founded in 2016 and is headquartered in New York.
• TasksMind — Customer Reliability Platform

Portfolio highlights

• Watch.fun — Open boxes, collect watches. Pull a Rolex today. Authenticated by Wristcheck. Backed by @SolanaVentures
• Squads — Collaborative infrastructure for web3 native teams
• Exponent Finance — Outperform market rates with Solana's leading yield exchange. Community: https://t.co/tROuLHqyfC

Portfolio highlights

• SkinBit — SkinBit is a healthtech company that develops AI-powered skin cancer detection, digital mapping, and health monitoring solutions.
• heXem bio — heXem bio specializes in recording solutions for the early development of humans for longevity.
• Elita — Store your dog's stem cells with Elita. One-time opportunity to protect their future health and avoid costly surgeries later in life.

Portfolio highlights

• Neosoul — NeoSoul uses an open architecture with autonomous agents operating under user-defined constraints to link agent intelligence, deterministic capital controls, and verifiable market execution.
• ORO — ORO is an AI-powered DeFi companion that lets users manage, trade, stake, lend, and research crypto assets through natural-language conversations, ORO aims to simplify onchain finance by bringing portfolio management and DeFi actions into one conversational interface.
• GAEA — GAEA is a decentralized artificial intelligence training network and data infrastructure platform focused on building a comprehensive multimodal emotional database.

Portfolio highlights

• XMTP — XMTP is a decentralized and quantum-resistant messaging protocol for builders.
• Ceramic Network — We've joined @textileio to build the first open intelligence network for AI agents. Follow us there.
• Superstate — Superstate is modernizing investing through tokenized financial products

Portfolio highlights

• Fab2 — Fab2 is a semiconductor technology company that designs and builds chip fabs, manufacturing tools, components, and software in-house.
• W4 Games — This is the homepage of the website
• Generalist AI — At Generalist, we are on a mission to build general intelligence for the physical world.

Portfolio highlights

• Disgo — Disgo is Operator of a customer loyalty and engagement platform
• Trufin — This account has moved to @TruYields. Follow us there for updates.
• LIFE AI — The clinical-development coordination layer for AI-generated drugs | Discord: https://t.co/gOvHPKVGYB | Telegram: https://t.co/DVjbfueQrk

Portfolio highlights

• Higgsfield — The ultimate AI-powered camera control for creators by creators
• Firelight — Firelight is a DeFi protocol that allows XRP holders can stake tokens and help cover risks on DeFi platforms.
• Alkemya Luxembourg — Alkemya Luxembourg is an international high tech metals firm specializing in sourcing and distributing rare earth oxides, titanium, and nickel wire, that are increasingly important to R&D and manufacturing companies in semiconductor, aerospace, and other high technology industries.

Portfolio highlights

• Kapkap — Kapkap is a web3 platform that uses AI for attention based value distribution in gaming.
• SuperIntent — SuperIntent is a cryptocurrency AI app that streamlines on-chain earning tactics. Developed on a multi-agent framework with abundant yield sources.
• Inference Labs — AI hyperscale on decentralized networks - We provide certainty for on-chain AI