Top 50 Blockchain Startup Investors in United States in May 2026

Portfolio highlights

• ETHGas — ETHGas aims to redefine how users engage with Ethereum by providing low-latency, 3ms settlement times, and real-time trading, as well as a comprehensive product suite for exact order execution.
• Rio Network — Rio Network is an operator of a public proof-of-stake blockchain platform intended for the issuance, investment, and life-cycle management of digital securities and crypto assets.
• Allora Labs — The source for NFT pricing. Upshot uses machine learning to provide deep insight into NFT markets and unlocks a wave of exotic new DeFi possibilities.

Portfolio highlights

• CertiK — CertiK, the largest Web3 security service provider, uses AI and formal verification to protect and monitor smart contracts and protocols, securing the Web3 ecosystem.
• Bastion — Bastion blends the best of web2 and web3 technologies to broaden opportunities for organizations and their customers.
• Onboard — Onboard strives to provide the best financial platform and community for on-chain developers and creators.

Portfolio highlights

• Gondi — Gondi is a non-custodial decentralized NFT lending protocol designed to build the most effective NFT credit market. The protocol allows for ongoing underwriting and full and partial refinancing of all outstanding loans, resulting in a more dynamic and liquid market.
• Ripio — Ripio, formerly known as Bitpagos, is a financial payments company that provides electronic payment solutions for businesses in Latin America. It offers a range of financial services for the emerging markets using blockchain technology to make a more accessible financial system. The company helps merchants process international transactions withcredit cards or bitcoins for a fraction of the cost as well as consumers buy bitcoins instantly with cash. It deals with clients in Argentina, Brazil, Chile, and Ecuador.
• Perion — Win Crypto Questing in AAA Games.

Portfolio highlights

• Zabo — Zabo is an API for connecting to any crypto exchange, wallet, protocol or account. Sign up for access to free API keys at Zabo.com
• Ballet — Ballet Crypto is a companion mobile app, which enables sending of cryptocurrency, checking market value and activating additional currencies. The use of the mobile app is completely optional, as you do not need it to receive and store your cryptocurrency safely.
• FLock.io — FLock.io aims to build a decentralised privacy-preserving solution for Artificial Intelligence.

Portfolio highlights

• Levr Bet — LEVR provides users with a decentralized sports betting platform that combines leveraged DeFi with traditional sports betting.
• TRM Labs — Next Generation Blockchain Intelligence | Monitor, Investigate, and Mitigate Crypto Fraud and Financial Crime
• Rio Network — Rio Network is an operator of a public proof-of-stake blockchain platform intended for the issuance, investment, and life-cycle management of digital securities and crypto assets.

Portfolio highlights

• Payy — Payy is a fintech application that enables stablecoin transactions, seamless payments, cryptocurrency wallets, and exchange services.
• Wildcat Labs — Wildcat Labs provides on-chain credit and grants access to a detailed view of all market parameters and logs for real-time monitoring.
• Euphoria — Euphoria is a crypto derivatives trading app that aims to simplify options and perpetual trading.

Portfolio highlights

• Tableland — A 3k generative NFT built from 1,074 handcrafted works of art for the builders and creatives of cyberspace.
• Ceramic Network — Ceramic Network is a provider of protocols for decentralized and composable data applications. The network decentralizes application databases, making data universally composable and reusable across applications. It consists of three core parts: a highly-scalable, decentralized infrastructure for data availability and consensus, a marketplace ofcommunity-created data models, and a suite of standard APIs for storing, updating, and retrieving data from those models.
• Tools For Humanity — Tools for Humanity is a technology company building for humans in the age of AI.

Portfolio highlights

• Aven — Inventing new ways to save people money
• Etherealize — Explore Etherealize: Your gateway to Ethereum-powered financial innovation. Discover research, insights, and products shaping the future of finance.
• The San Francisco Compute Company — The San Francisco Compute Company manufactures supercomputers.

Portfolio highlights

• Evolv — Evolv is equipping brands with the technology to create immersive experiences for their customers.
• Ceramic Network — Ceramic Network is a provider of protocols for decentralized and composable data applications. The network decentralizes application databases, making data universally composable and reusable across applications. It consists of three core parts: a highly-scalable, decentralized infrastructure for data availability and consensus, a marketplace ofcommunity-created data models, and a suite of standard APIs for storing, updating, and retrieving data from those models.
• Ignite Tournaments — Ready to take your mobile games to the next level? Join Ignite Tournaments and compete in real money esports tournaments. Download our app now and win big!

Portfolio highlights

• Kapkap — Kapkap is a web3 platform that uses AI for attention based value distribution in gaming.
• BullPerks — BullPerks is a community of like-minded individuals who want to leverage their power and invest together in the best projects on equal terms with VCs.
• Mythic Protocol — The Central Hub for Mythic Operatives to conduct their operations

Portfolio highlights

• Raad Labs — We're building the sensory network which the world's authorities have overlooked: unlocking Billions through crowdsourced weather data.
• Ceramic Network — Ceramic Network is a provider of protocols for decentralized and composable data applications. The network decentralizes application databases, making data universally composable and reusable across applications. It consists of three core parts: a highly-scalable, decentralized infrastructure for data availability and consensus, a marketplace ofcommunity-created data models, and a suite of standard APIs for storing, updating, and retrieving data from those models.
• Tools For Humanity — Tools for Humanity is a technology company building for humans in the age of AI.

Portfolio highlights

• fomo — Fomo is a cutting-edge fintech startup revolutionizing the financial landscape through innovative technology and strategic partnerships.
• Blitz Electric Mobility — Blitz provides electric vehicles and fleet management software to food and beverage delivery, courier, and logistics companies.
• Blueprint Bryan Johnson — On the surface, Blueprint may seem something about health, wellness and aging. It's really a system to make tomorrow better for you, me, the planet and our shared future with AI.

Portfolio highlights

• Drosera — Drosera is a decentralized incident response system that uses hidden security intentions to contain and mitigate attacks.
• bbox — bbox offers professional trading on the Decentralized Perpetual Exchange and hybrid markets.
• Delegate — Delegate focuses on increasing the security of on-chain identities and digital asset management such as NFTs and ERC20 tokens.

Portfolio highlights

• Canza Finance — We are an Open Finance Portal enabling access to unlimited financial services for emerging markets, backed by Polychain, Avalanche, CoinMarketCap...
• OceanEx — OceanEx is one of the fastest-growing and reputable cryptocurrency exchange.
• AlchemyNFT — AlchemyNFT is a non-fungible token (NFT) service.

Portfolio highlights

• MoonPay — MoonPay offers a fast and simple way to buy and sell cryptocurrencies. Buy crypto with credit card, bank transfers or Apple Pay today.
• GTE — GTE is a decentralized trading platform that offers end-to-end trading services.
• o1Labs — Catalyzing a new generation of applications powered by zero knowledge cryptography.

Portfolio highlights

• Perion — Win Crypto Questing in AAA Games.
• Bitlayer — Bitlayer is the first Bitcoin second-layer network, based on BitVM, offering ultra-scalability and L1 security, aiming to be Bitcoin's computing layer.
• Space and Time — Space and Time is the first decentralized data warehouse. Powering low-latency queries and tamperproof Web3 analytics. Web3 analytics at scale. A multichain data platform for dapps needing next-gen Web3 analytics. Connect analytics directly to smart contracts. Join on-chain and off-chain data in a single query.

Portfolio highlights

• Mudafy — Mudafy is a tech-enabled real estate broker for LatAm.
• 0G — The First Decentralized AI Operating System
• Initia Labs — Initia unites full-stack apps and unlocks value through interwoven infrastructure and aligned economics.

Portfolio highlights

• Solana — Solana is the high performance network powering internet capital markets, payments, and crypto applications. Fast. Decentralized. Scalable. Energy efficient. Solana can power thousands of transactions per second.
• Remix — Remix is a platform combining AI and mobile gaming, designed to offer on-chain, AI-powered games.
• Fjord Foundry — Fjord enables teams the ability to openly and fairly generate liquidity by connecting inspired projects with passionate supporters via Liquidity Bootstrapping Pools.

Portfolio highlights

• ether.fi — EtherFi is a non-custodial decentralized ETH staking method that distributes staking to node operators in exchange for rewards.
• Azuro — Powerful tooling, oracle & liquidity solutions for any EVM predictions & gaming ecosystem
• QED Protocol — A trustless, scalable, decentralized compute protocol for a fairer internet focused on user privacy and platform transparency.

Portfolio highlights

• TRM Labs — Next Generation Blockchain Intelligence | Monitor, Investigate, and Mitigate Crypto Fraud and Financial Crime
• Synervest — Synervest Group is a fintech platform offering regulated cross-border trading, payments, and financial technology infrastructure for institutional clients, for both B2B and B2C models. It's headquartered in ADGM and operates in Europe and the Middle East, with offices in the UK and Cyprus.
• Cookie3 — Cookie3 is an AI-driven MarketingFi platform bridging Web2 and Web3 by providing comprehensive analytics spanning off-to-on-chain data, applied across 12+ EVM blockchains to enhance user journey tracking, attribution, and campaign ROI. It includes tools like analytics dashboards, CRM, campaign manager, affiliate marketplace, reputation scoring, andan airdrop shield; all unified by its token and Cookie DAO for governance and user rewards. It empowers campaigns with AI insights, fraud protection, and a transparent, incentivized marketing economy.

Portfolio highlights

• Revolut — Join 40+ million customers globally using Revolut to send money to 160+ countries, hold up-to 36 currencies in app, spend in 150+ currencies, and manage their money.
• Platfora — Platfora’s mission is to empower customers to transform their businesses into fact-based enterprises. Platfora's Big Data Analytics Platform masks the complexity of Hadoop, making it easy for customers to understand all the facts in their business across events, actions, behaviors and time.
• Lead — Lead Bank is a community-minded, independent commercial bank with a national client base recognized for its imaginative approach to community banking.

Portfolio highlights

• Ad-Shield — Start measuring revenue lost to ad blockers and learn how to get additional revenue through Ad-Shield Recovery today
• Injective — Explore Injective: the high-performance blockchain powering decentralized finance, governance, and next-gen Web3 apps with unmatched speed and scale.
• Decentralised Gaming Ventures — D.G.Pals is a virtual pet, NFT Game Project that focuses on Squad-battler (PvP and Competitive), Siege Defence, Clan System, and various types of genre revolving around the IP as part of the ecosystem in the D.G.Verse.

Portfolio highlights

• Ethena — Enabling the Internet Bond
• Ref Finance — Ref Finance is a DeFi platform built on NEAR Protocol that costs less than $0.01 for transactions.
• Parallax — Parallax offers a cross-border payments platform for freelancers, remote workers, and businesses. The service enables receiving international client payments, holding funds in USD, exchanging currencies, and sending money to domestic bank accounts and mobile wallets. Users manage balances and transfers through a web app with quoted rates anditemized fees. The platform supports global payouts and recurring disbursements to partners and team members. Compliance measures include identity verification and transaction monitoring aligned with regulatory standards. Documentation and support resources guide account setup, funding, and cash-out.

Portfolio highlights

• Rayls — Rayls is the most compliant blockchain infrastructure that enables real-world asset (RWAs) tokenisation, CBDCs, cross-border payments and access to regulated liquidity on public chain.
• Thesis — Thesis is a cryptocurrency venture production studio. We build and invest in products that empower individuals.
• Commonwealth Labs — Commonwealth Labs is a governing a set of global stakeholders is hard, especially for blockchain-based protocols. Protocols need clear governance for prompt feature implementation, accountable project teams, and correct resource allocation. We facilitate scalable governance and decision making for protocols and organizations.

Portfolio highlights

• CLST — Buy & sell Bitcoin and cryptos with our easy and seamless Uncollateralized lending. Tust the world's finest crypto borrowing, trading or exchange platform
• Solana — Solana is the high performance network powering internet capital markets, payments, and crypto applications. Fast. Decentralized. Scalable. Energy efficient. Solana can power thousands of transactions per second.
• Perion — Win Crypto Questing in AAA Games.

Portfolio highlights

• pieverse — Pieverse is a Web3 platform that turns people’s time into tradable digital value.
• Zoo Finance — Zoo Finance is a pioneering DeFi protocol focused on unlocking liquidity from locked assets, empowering users to access capital more efficiently while maximizing the utility of their on-chain holdings.
• Injective — Explore Injective: the high-performance blockchain powering decentralized finance, governance, and next-gen Web3 apps with unmatched speed and scale.

Portfolio highlights

• AI Seer — AIs for Authenticating Information. AI Seer is on a mission: To Check Untruths before they become Powerful through an Antivirus for Mal-information, Dis-information and Misinformation.
• Scout AI — Scout AI is building the robotic foundation model for defense.
• Aurelius Systems — Aurelius Systems is a defense technology company pioneering the future of defense with the development of edge-deployed, AI-powered laser systems designed to counter unmanned aerial systems (UAS) threats.

Portfolio highlights

• LOLIWARE — LOLIWARE is rewriting the story of destructive packaging. By harnessing the power of seaweed to replace plastic at scale, LOLIWARE is tapping into its potential to regenerate our ocean and decarbonize our planet.
• Kolors — Kolors is a technological platform that focuses on providing intelligent intercity mobility of bus transportation in the region.
• ARRIS — Using next-gen advanced manufacturing technologies, ARRIS Composites produces smarter, lighter, stronger, and more sustainable products at scale.

Portfolio highlights

• Raiku — Raiku is a Web3 infrastructure startup focused on enhancing the Solana blockchain's reliability and predictability.
• Kapkap — Kapkap is a web3 platform that uses AI for attention based value distribution in gaming.
• Haiku — Haiku is a DeFi platform that lets users execute complex multi-chain trades and strategies in simple, optimized transactions.

Portfolio highlights

• AltLayer — AltLayer is a system of highly scalable application-dedicated execution layers that derive security from an underlying L1/L2.
• AlchemyNFT — AlchemyNFT is a non-fungible token (NFT) service.
• Mask Network — Your Portal To The New, Open Internet.

Portfolio highlights

• 14.ai — 14.ai is a pioneering AI-native customer support for business-to-consumer brands that replaces human agents with autonomous AI.
• depthfirst — An AI-native security platform that understands your code, business logic, and infrastructure to find more vulnerabilities, slash false positives, and give developers actionable fixes in their workflow.
• Black Forest Labs — Black Forest Labs creates advanced generative deep learning models for images and videos. They focus on making these technologies widely accessible and transparent, ensuring that their innovations are easy to use and understand. This approach aims to democratize access to cutting-edge technology and foster greater trust and utility.

Portfolio highlights

• Gro — Gro protocol is a stablecoin yield aggregator that tranches risk and yield. The first two products built on it are the PWRD stablecoin with deposit protection and yield, and Vault with leveraged stablecoin yields.
• TRM Labs — Next Generation Blockchain Intelligence | Monitor, Investigate, and Mitigate Crypto Fraud and Financial Crime
• Bullish Global — Bullish Global is a new blockchain-based cryptocurrency exchange designed to combine the performance, user privacy, and compliance offered by central order book technology with the vertically integrated user benefits of decentralized finance (DeFi) market architecture.

Portfolio highlights

• worm.wtf — worm.wtf is the prediction marketplace for the Solana ecosystem.
• Voyage — Voyage AI is an AI infrastructure project building the first GEOFi network to make AI-generated content citable.
• Circuit & Chisel — Circuit & Chisel is an agentic AI platform that enables agents to make transactions between autonomous agents.

Portfolio highlights

• EigenLabs — Eigen Labs is an engineering and research organization that contributes to protocols like EigenLayer and EigenDA
• Bastion — Bastion blends the best of web2 and web3 technologies to broaden opportunities for organizations and their customers.
• Story Protocol — Story is AI-native infrastructure for the intellectual property economy.

Portfolio highlights

• Runes DEX — Swap Runes for BTC seamlessly, enjoy low fees, fast transactions, and earn yield as a liquidity provider.
• Nyan Heroes — Nyan Heroes is an immersive NFT based shooter of futuristic revolutions, cats in robots, evil corporations.
• Hexagon Wireless — Hexagon Wireless is a provider of decentralized wireless technology.

Portfolio highlights

• Tradoor — Tradoor protects traders, LPs, and the protocol against unforeseen market fluctuations by using clever math and safety measures to enable traders to trade with confidence.
• Runes DEX — Swap Runes for BTC seamlessly, enjoy low fees, fast transactions, and earn yield as a liquidity provider.
• Nested — The best decentralized portfolio management & copy trading experiences

Portfolio highlights

• Flood — Flood: The best DEX aggregator to optimize your trading. Experience top rates, zero gas fees, and full MEV protection. Trade across Arbitrum and Ethereum today.
• Stack — Recognize and reward the relationships that matter
• Reservoir — Infrastructure and APIs to bring efficient token markets to every chain, wallet, and app

Portfolio highlights

• Mash — The internet is fundamentally broken. It's because of monetization. “Show me the incentives and I'll show you the outcome.”Our mission is to remonetize the web by enabling value for value monetary exchanges between pubs/creators/orgs and their users. A new business model for the open internet.We are unlocking this withfriction-minimized streaming payments that are no/low cost, instantly settled, trust-minimized.It is built on the best global digital monetary network ever conceived, Bitcoin. Enabled by Lightning Network. Most users don't need to know this or be a Bitcoiner. Over time we suspect many will.
• Groma — We use technology to make properties work better and enable everyone to own a stake in their community. Join Groma in transforming real estate. Rent modern homes, invest in multifamily buildings, or become part of our resident investor community.
• Project Eleven — Project Eleven is a development company dedicated to advancing post-quantum cryptography solutions.

Portfolio highlights

• KINO — KINO is a film production company that brings fans behind the scenes of their favorite hollywood films.
• DeepNode AI — DeepNode connects researchers, data scientists, and enterprises into one transparent, verifiable network for building real-world AI. DeepNode AI a technology service provider focusing on decentralized AI infrastructure,
• Renaissance — Renaissance allows artists to amplify their streaming traction and tap into a community of their super fans.

Portfolio highlights

• worm.wtf — worm.wtf is the prediction marketplace for the Solana ecosystem.
• Bullpen — Bullpen is completely non-custodial and protected by Turnkey's enterprise-level private key management infrastructure. Users can benefit from military-grade protection while maintaining total control over their assets thanks to an air-gapped architecture.
• Ceramic Network — Ceramic Network is a provider of protocols for decentralized and composable data applications. The network decentralizes application databases, making data universally composable and reusable across applications. It consists of three core parts: a highly-scalable, decentralized infrastructure for data availability and consensus, a marketplace ofcommunity-created data models, and a suite of standard APIs for storing, updating, and retrieving data from those models.

Portfolio highlights

• Everlyn — Everlyn is a Web3 video AI model that generates a decentralized infrastructure layer for autonomous video.
• Voyage — Voyage AI is an AI infrastructure project building the first GEOFi network to make AI-generated content citable.
• Cold River Games — Crystalfall is an upcoming free online action RPG with customizable skills and an endless endgame, set in a steampunk world.

Portfolio highlights

• 0G — The First Decentralized AI Operating System
• Optic — Optic monitors blockchains to reveal the origins of any NFT and how it’s been reimagined, remixed, or copied.
• Folks Finance — Folks Finance is a permissionless DeFi lending platform where users can lend and borrow crypto across chains, access loans, and manage digital assets in one unified liquidity protocol.

Portfolio highlights

• Thesis — Thesis is a cryptocurrency venture production studio. We build and invest in products that empower individuals.
• Pye Labs — Pye Finance is a Web3 startup that builds a staking-market infrastructure on the Solana blockchain.
• Union Labs — The Modular ZK Interoperability Layer

Portfolio highlights

• MoonPay — MoonPay offers a fast and simple way to buy and sell cryptocurrencies. Buy crypto with credit card, bank transfers or Apple Pay today.
• Conta Simples — Conta Simples is the all-in-one finance plataform. The union of checking account, expense management software and corporate cards in one place. We bring peace to finance teams and entrepreneurs. Control, visibility, autonomy and decentralization of payments for SMBs in Latam.
• Diadia Health, Inc — An AI medical reasoning platform that helps clinicians analyze the root causes of symptoms and create personalized protocols that drive better outcomes.

Portfolio highlights

• Pyth Network — The Pyth network is a specialized oracle solution for latency-sensitive financial data that is typically kept behind the “walled gardens’’ of centralized institutions. The Pyth network is focused on finding a new and inexpensive way to bring this unique data on-chain and aggregating it securely.
• Ceramic Network — Ceramic Network is a provider of protocols for decentralized and composable data applications. The network decentralizes application databases, making data universally composable and reusable across applications. It consists of three core parts: a highly-scalable, decentralized infrastructure for data availability and consensus, a marketplace ofcommunity-created data models, and a suite of standard APIs for storing, updating, and retrieving data from those models.
• Fogo Digital — Fogo is a high-performance SVM Layer-1 built for pros who trade at the speed of light. Sub-40ms block times, gas-free sessions, and fair execution. no latency, no friction, no bullshit.

Portfolio highlights

• Base Power — Base provides a battery-powered home energy service so you can enjoy power without interruption and save money. Now available in select regions of Texas.
• Castelion — We are a modern defense production company building the next generation of military hypersonic, vehicle, and strike systems to deter future wars.
• ScaleOps — ScaleOps is the industry's first Kubernetes optimization platform that automatically optimizes compute resources in real-time.

Portfolio highlights

• Yoz Labs — Save time, streamline your development, and reach users on their preferred channels
• Ceramic Network — Ceramic Network is a provider of protocols for decentralized and composable data applications. The network decentralizes application databases, making data universally composable and reusable across applications. It consists of three core parts: a highly-scalable, decentralized infrastructure for data availability and consensus, a marketplace ofcommunity-created data models, and a suite of standard APIs for storing, updating, and retrieving data from those models.
• Halfbrick Studios — Creators of Fruit Ninja and Jetpack Joyride and more mobile mega hits!

Portfolio highlights

• HIFI — HiFi Bridge is a cryptocurrency payments platform that allows customers to buy and sell cryptocurrencies, trade NFT's, borrow loans, and connect their bank accounts all-in-one.The startup offers equity, cryptocurrency, and options trading, as well as cash management accounts. The company provides the accessibility for traditional financialusers to gain access to modern decentralized finance tools through it's mobile and web platform.Zach Walsh and Mohamed Afifi founded the company in New York City in 2021.
• Maestro — Advanced UTxO-indexing data layer to supercharge Defi on Bitcoin, Cardano & Dogecoin.
• Crypto Valley Exchange — The first portfolio risk capable platform for Options & Futures trading in DeFi, offering 1000x+ leverage based on margin offset.

Portfolio highlights

• Guild — Guild is a decentralized platform leveraging AI to augment creation, ownership, distribution and monetization of content and digital goods. AI plays a pivotal role in automating tasks, providing data-driven insights, and offering strategic guidance to creators. Whether it's managing marketing campaigns, optimizing release schedules, oridentifying new opportunities, the AI in Guild serves as an invaluable tool for artists, producers, and songwriters. The platform's blockchain integration ensures that all music assets are securely owned and transparently managed, giving creators full control over their work. By combining the practical benefits of AI—like process automation and data analysis—with the security of blockchain, Guild empowers creators to focus on their craft while effectively managing their careers.
• Folks Finance — Folks Finance is a permissionless DeFi lending platform where users can lend and borrow crypto across chains, access loans, and manage digital assets in one unified liquidity protocol.
• Symbiotic — Symbiotic is a generalized shared security system enabling decentralized networks to bootstrap powerful, fully sovereign ecosystems.

Portfolio highlights

• HIFI — HiFi Bridge is a cryptocurrency payments platform that allows customers to buy and sell cryptocurrencies, trade NFT's, borrow loans, and connect their bank accounts all-in-one.The startup offers equity, cryptocurrency, and options trading, as well as cash management accounts. The company provides the accessibility for traditional financialusers to gain access to modern decentralized finance tools through it's mobile and web platform.Zach Walsh and Mohamed Afifi founded the company in New York City in 2021.
• Maestro — Advanced UTxO-indexing data layer to supercharge Defi on Bitcoin, Cardano & Dogecoin.
• Criptonite Asset Management — Criptonite Asset Management's exists to offer qualified & institutional investors a tailored, liquid and proven approach to cryptocurrency investments.