Top 50 Startup Investors in Panama (November 2026)

Portfolio highlights

• OP_NET — OPNET is a Bitcoin Layer 1 metaprotocol that enables smart contracts to function directly on the Bitcoin blockchain, without the use of sidechains or Layer 2 solutions.
• Watch.fun — Watch.fun is a platform that offers ticket-based entries for luxury watch giveaways.
• Space — Space is a leveraged prediction market platform built on Solana, designed to reward users for accurate insights while enabling efficient capital flow through competitive forecasting, combining high-performance blockchain infrastructure with advanced market mechanisms to create a transparent, scalable, and engaging environment for decentralizedprediction and informed decision-making.

Portfolio highlights

• OpenPad AI — OpenPad - The 1st AI Decentralized Launchpad
• Stabble — We deposited and withdrew real crypto to rank the best crypto casinos in Canada. Compare payout speeds, bonuses, coins and licences for our top 10.
• AI Cross Matrix — AI Cross Matrix is a DeFi platform that makes the crypto economy simple by streamlining the exchange process with useful solutions.

Portfolio highlights

• A-World — Welcome to Animal World, a battle game based on #BNBCHAIN's super metaverse card tower defense. By setting up a hero tower to destroy monsters.
• NeuronX — NeuronX Protocol is the pioneering decentralized lending protocol on Dfinity, setting the stage for smart DeFi. By focusing on AI-driven automation and enhanced user experiences, NeuronX aims to revolutionize the DeFi landscape and appeal to a broader audience. At the core of NeuronX is a groundbreaking innovation: AI-Powered Smart LiquidityPlatforms (AILPs). These AILPs are advanced vault strategies operated by intelligent AI algorithms. Users can effortlessly gain leverage by simply depositing a base asset. Behind the scenes, AILPs leverage AI to automate complex transactions and continuously rebalance positions, ensuring optimal leverage without the risk of liquidation. This integration of AI streamlines the process, making advanced financial strategies accessible and hassle-free.
• Vue Protocol — Community-First Layer for AI Memecoins. @solana @pumpdotfun @ton_blockchain Dvo1Fb7FxtUxsLbcQaizftfUT9HtL9P6swaQAScZDeQQ

Portfolio highlights

• EBR Systems — EBR aims for outstanding treatment of cardiac rhythm diseases with an innovative leadless therapy.
• Cardiac Dimensions — Cardiac Dimensions, Inc. is a medical device company developing novel interventional tools for the treatment of heart failure and the related condition of mitral valve regurgitation. Our product, the Carillon® Mitral Contour System®, is a groundbreaking, non-surgical device developed to treat functional mitral valve regurgitation. Our system uses acatheter based approach to reshape the mitral valve and reduce mitral regurgitation.
• Ignite Tournaments — Empower content creators to launch custom quest lines, track fan engagement, and manage premium subscription communities.

Portfolio highlights

• Rivalz Network — Join the connectivity infrastructure between AI Agents, DeFAI and Markets.
• The Arena — A next gen SocialFi app redefining how creators connect, engage, and monetize their content.
• Sigma Computing — Sigma is the only BI analytics tool purpose-built for your cloud data warehouse. Uniquely scalable, with an experience you already know: the spreadsheet.

Portfolio highlights

• MSafe — MSafe offers the most secure, decentralized, scalable Web3 non-custodial, multi-signature solution built on Move, ideal for dApp developers to use for treasury management, token management, smart contract development, blockchain protocol admin control, live on Aptos
• Polysights — Polysights is the intelligence and execution layer for prediction markets: market discovery, a trading terminal, research, and insider tracking in one place.
• Turtle Club — Aggregated, diligenced, personalized onchain yield management.

Portfolio highlights

• myco — Stream English Premier League, live cricket, international TV channels, web series, movies from Hollywood, Bollywood, Turkish, Irani, and Pakistani dramas.
• Metametaverse — Discover the future of virtual worlds with our metaverse platform. Explore, create and monetize your own metaverse experiences in a seamless and secure manner. Join the cosmic system of metaverses today.
• Ignite Tournaments — Empower content creators to launch custom quest lines, track fan engagement, and manage premium subscription communities.

Portfolio highlights

• 3VO — Bring Your Business On-chain. The easiest way to launch, grow, and own your brand with AI + Web3 tools - all in one simple, social platform.

Portfolio highlights

• Quotr.ai — Quotr.ai is the all-in-one pre-construction engine built to bridge the costly "takeoff-to-transaction" gap for modern subcontractors, contractors and developers. The San Francisco-based platform serves every construction trade by consolidating fragmented workflows into a single workspace. Instead of bouncing between disjointed tools,users can seamlessly transition from advanced AI takeoffs and estimates to competitive bidding, material procurement, and developer proformas. To directly improve project margins, Quotr.ai integrates dynamic material list matching, connecting users with diverse suppliers to source materials cheaper and faster. Quotr.ai enables teams to slash material costs by up to 40% and cut estimation time by 90%, bringing modern, high-ROI software to one of the world's largest industries. Backed by Llama Ventures, Quotr.ai is rapidly becoming the platform of choice for forward-thinking construction firms with a mission to make pre-construction faster, easier, and more accurate.
• AEON — AEON is a crypto payment framework designed for AI-driven and real-world transactions. It supports omni-chain payments across ecosystems like EVM, SVM, and TON, enabling seamless cross-chain usage. Its solutions include AI-powered payments, Web3 online and mobile payments, QR/contactless acceptance, and swap pay, all designed to simplifyadoption for users and merchants.
• KOR Protocol — KOR Protocol is a decentralized intellectual property (IP) infrastructure designed to empower creators, protect rights, and enable seamless collaboration and monetization of IP assets across various industries, including music, film, TV, gaming, and art. Backed by notable entities like Animoca Brands, Republic, Niantic, Sfermion, Solana, andprominent creators such as Black Mirror, Disclosure, deadmau5, and Richie Hawtin, KOR leverages blockchain, AI, and DeFi to offer a transparent, efficient, and scalable environment for IP expansion.

Portfolio highlights

• Treyee — We engineer revolutionary AI products and solutions that redefine enterprise capabilities. Our cutting-edge technology transforms raw data into strategic intelligence, empowering organisations to dominate markets, automate at scale, and unlock unprecedented opportunities. We're building the future where ambitious enterprises lead throughintelligent innovation.

Portfolio highlights

• Capx — Run a company from your terminal. Casa, Launchpad, Terminal.
• DeepSafe — The world's 1st CRVA (Crypto Random Verification Agent) solution, leveraging MPC, ZKP, TEE & RingVRF, creates a secure verification network for blockchain & AI.
• aPriori — Intelligent Order Flow Coordination Layer for High-Performance Blockchains

Portfolio highlights

• Treyee — We engineer revolutionary AI products and solutions that redefine enterprise capabilities. Our cutting-edge technology transforms raw data into strategic intelligence, empowering organisations to dominate markets, automate at scale, and unlock unprecedented opportunities. We're building the future where ambitious enterprises lead throughintelligent innovation.

Portfolio highlights

• Wizzwoods — 1st pixel farm game integrates interchain capabilities with a SocialFi twist.
• SuperIntent — Discover intelligent crypto investing with SuperIntent. Supercharged by DeFAI, it's your all-in-one app for smarter strategies and stress-free asset management.
• SuperGaming — At SuperGaming, we are putting India on the global gaming map.

Portfolio highlights

• Nicegram — Nicegram is a fast, secure and nice messaging app that perfectly includes all Telegram features and offers additional ones which are ideally made for all modern people and businesses.
• Hana Network — Hana Network is Hypercasual finance with social network effects.
• Cluster Protocol — Liberation Engine for Internet Capital Market

Portfolio highlights

• Rebill — Rebill.com is the payments and subscriptions platform specifically designed for digital businesses and global companies scaling in Latin America.With our platform and API, companies can integrate over 100 local payment methods from the region, including cards, bank transfers, cash, and even wallets. In addition, they always receive the best humansupport with fair pricing and utmost transparency, enabling them to scale across the region 10 times faster.We are backed and have received investment from some of the world's leading funds such as Tiger Global Management, Soma Capital, SV Angel, Y Combinator, as well as incredible angel investors like Guillermo Rauch (Vercel), Arash Ferdowsi (Dropbox), among others.
• FirstWork — Applied AI for frontline enterprises. Forward-deployed AI agents that automate workforce operations inside your existing systems.
• Ramp — Join thousands of forward-thinking businesses using Ramp to control spend, save time, and automate busywork.

Portfolio highlights

• Orix AI — Orix is the ultra-fast AI agent for code and fintech. It plans, writes, audits and ships code and smart contracts in seconds.
• ChimpX AI — ChimpX AI is an AI-powered decentralized finance (DeFi) superapp designed to simplify crypto trading, cross-chain asset management, and blockchain interactions through natural language commands. The platform focuses on making complex DeFi operations accessible to everyday users by combining artificial intelligence, automation, and gaslesstransactions into a single interface.
• Harry Howard — An AI-powered incubation platform that transforms Web3 innovation from concept to launch through intelligent automation and community governance. Visit our X Visit our Launchpad

Portfolio highlights

• ShoeFy — ShoeFy is a decentralized project that combines nonfungible tokens (NFTs) and fungible tokens (FTs) on one platform to add new utility layers to NFTs.
• CryptoTanks — CryptoTanks is a play-to-earn platform where every NFT is usable in a gamified DeFi ecosystem. With the tanks, the player earns money and plays games partially owned and operated by their players. Earn tank tokens by playing and use them to decide the future of the game. They offer design and prizes that come with gamified yield farming.
• Astra Guild Ventures — Astra Guild Ventures is one of the world's play-to-earn gaming guilds. Astra Guild Ventures is bridging the gap between players and investors in order to capitalize on the growth of non-traditional games.

Portfolio highlights

• Cancore — Cancore operates a non-custodial cross-chain trading and settlement platform that links institutional assets on the Canton Network with public blockchain liquidity pools. The platform enables native-to-native atomic swaps across separate ecosystems via smart contracts without requiring wrapped assets, centralized custody, or third-party validator sets. Through this structure, users maintain full control of their private keys while automating and routing transaction flows across multiple public networks.
• ORO — ORO is an AI-powered DeFi companion that lets users manage, trade, stake, lend, and research crypto assets through natural-language conversations, ORO aims to simplify onchain finance by bringing portfolio management and DeFi actions into one conversational interface.
• GAEA — GAEA is a decentralized artificial intelligence training network and data infrastructure platform focused on building a comprehensive multimodal emotional database.

Portfolio highlights

• SQR3D — Transform your idea into 3D assets at scale. Smart Contract Automation for 3D Designs with SQR3D.
• Reitio Protocol — We’re creating an effortless way for everyone to create custom metaverse assets visually via an intuitive and codeless templates-based design toolkit, introducing reitio protocol.
• Genesis Shards — Crafting a whole new suite of NFT powered products across multiple blockchains

Portfolio highlights

• GAMES.GG — Discover 1,500+ games with honest reviews, expert guides, and daily gaming news across PC, console, and mobile. Find your next favorite game on Steam, Epic Games, PlayStation, Xbox, and Nintendo.
• Sumer Money — Sumer Money is a cross-chain synthetic assets protocol that enables composable Defi across blockchains.
• SYNTRA — Syntra is an AI-driven trading infrastructure company focused on disciplined execution, real-time risk management, and transparent market operations in digital asset markets. The company builds systems that monitor market structure, volatility, liquidity, and correlation dynamics, enabling automated decision-making with strict risk controls.Syntra’s infrastructure is designed to prioritize execution quality, capital preservation, and operational transparency over short-term performance optimization.Syntra operates a live execution environment where all system actions are observable in real time, providing an open view into how the trading system behaves across different market conditions. The platform is infrastructure-first, emphasizing robustness, scalability, and controlled growth rather than aggressive user acquisition. The company is currently focused on expanding its execution stack, data pipelines, and risk management framework to support broader market coverage and institutional-grade reliability.

Portfolio highlights

• Superlogic — OneOf is the mass-consumer Web3 company connecting the next 100M non-crypto-native fans to iconic brands, artists, and athletes. OneOf technology enables global brands and enterprises to reimagine commerce, loyalty and engagement, allowing consumers to seamlessly collect or trade digital assets with no prior crypto expertise. Deeply committed to a sustainable and inclusive blockchain future, minting digital assets on OneOf's platform uses up to 2 million times less energy than previous generation proof-of-work networks, and costs up to 99% less in gas fees. A leader in diversity, over 80% of the collections curated by OneOf come from minority or female creators.
• PERPTools — PERPTools combines crypto perpetual trading with activity points and risk-free market predictions.
• Bullshot Inc — Bullshot is redefining the way meme tokens are launched, traded, and adopted. By combining AI-driven automation with the power of community culture, Bullshot creates an ecosystem where creativity, speed, and scalability thrive.

Portfolio highlights

• DHL — DHL is a division of the German logistics company Deutsche Post DHL that provides international express mail services. Deutsche Post is a large-scale logistics company operating around the world. DHL provides world market services both in sea and air mail.DHL was primarily interested in offshore and inter-continental deliveries, but the successof FedEx prompted its own intra-U.S. expansion starting in 1983. DHL aggressively expanded to countries that could not be served by any other delivery service, including the Soviet Union, Eastern Bloc, Iraq, Iran, China, Vietnam, and North Korea.Deutsche Post then effectively absorbed DHL into its Express division, while expanding the use of the DHL brand to other Deutsche Post divisions, business units and subsidiaries.Originally founded in 1969 to deliver documents between San Francisco and Honolulu, the company expanded its service throughout the world by the late 1970s. DHL was founded in 1969 and is based in Bonn.
• ShoeFy — ShoeFy is a decentralized project that combines nonfungible tokens (NFTs) and fungible tokens (FTs) on one platform to add new utility layers to NFTs.

Portfolio highlights

• Ignite Tournaments — Empower content creators to launch custom quest lines, track fan engagement, and manage premium subscription communities.

Portfolio highlights

• Bluwhale — Unlock Web3 Wallet Potential with AI Insights. Supercharge Your Business Growth
• BluWhale — Premium domain available for acquisition.
• Sorted Wallet — Send USDt and Bitcoin home in minutes and cash out straight to M-Pesa, MTN MoMo, bKash or JazzCash. Your keys, your money, no bank account needed.

Portfolio highlights

• SnakeLite — Predict the performance of Hyperliquid traders, track the flow of smart funds, and earn profits in the decentralized prediction market through AI signals and real-time data.
• Sophon — Soph(+) is a tech studio building novel consumer experiences in crypto and ai. we build, own, and ship our own products, starting with pyre.
• A.A.A C(H+A)RM — AAA C(H+A)RM (Autonomous AI Agents Launchpad & Layer3) is the first AI-first, agent-focused orchestration platform.

Portfolio highlights

• Meta Pool — Liquid stake NEAR, ETH and SOL with Meta Pool, the DAO-governed staking protocol running since 2021. Earn staking rewards and stay liquid with stNEAR.
• Amnis Finance — Stake APT on the best liquid staking protocol on Aptos to receive daily rewards with an attractive APR of 2%.
• Velvet Capital — Follow top traders and KOLs, track 13M+ wallets and trade memecoins, spot and perps with an AI copilot on 11+ chains. Non-custodial, up to 100% cashback.

Portfolio highlights

• Minicor — Minicor agentically builds self-healing automations on any no-API system, then hands you an API endpoint to call.
• Hop Aero — Hop Aero develops hypersonic rocket cargo systems that provide rapid point-to-point delivery across long distances. The company focuses on rocket cargo vehicles designed to transport supplies to austere and contested locations within minutes. Its systems aim to support logistics operations that require fast response times and resilient supply chains. Hop Aero positions its technology as part of a broader physical internet concept, enabling high-speed movement of physical goods similar to data on the internet. The company targets users that need time-critical delivery capabilities in challenging operational environments.
• Lightsprint — LightSprint is the software factory for product teams. PMs, designers and ops build in a shared cloud workspace while engineering controls every merge.

Portfolio highlights

• Portal to Bitcoin — The only custody-less interoperability protocol for Bitcoin. Swap native BTC, Ordinals, Runes with L2s and L1s
• NAKA — Elly POS is an irreplaceable all-in-one device with multiple payment methods. Accepting cards, crypto and digital payments. Future-proof, transparent and secure.
• Acta Finance — Acta Finance develops a complete DeFi ecosystem, EVM compatible, able to deploy and integrate EVM compatible networks.

Portfolio highlights

• Cyrator — Decentralized news platform dedicated to fighting misinformation, powered by the people for unbiased, truthful news!
• Bored Slot — Bored Slot offers real live slots gaming with the basic interest of slot using blockchain technology.
• Orochi Network — Orochi Network's Verifiable Data Infrastructure is a promising step towards a more secure, scalable, and user-friendly Web3.

Portfolio highlights

• Fjord Foundry — Fjord enables teams the ability to openly and fairly generate liquidity by connecting inspired projects with passionate supporters via Liquidity Bootstrapping Pools.
• Zaros Finance — Zaros is a protocol that provides efficient liquidity, boosts staking rewards from LSTs, and aims to become the preferred liquidity hub for on-chain derivatives.
• Layer Social Labs — A home for global companionship and endless entertainment. Post More, Play More, Earn More.

Portfolio highlights

• Capx — Run a company from your terminal. Casa, Launchpad, Terminal.
• Noodles Finance — The no-brainer trading platform for Sui.
• YOAKE Entertainment — YOAKE Entertainment is a music studio that specializes in the planning, production, and development of entertainment content.

Portfolio highlights

• Starbots — Starbots is Solana's first-ever battle NFT game.
• Linear — Linear allows the user to manage software development and track bugs. Built for speed and efficiency.The founders started Linear from their own frustrations building software projects in successful high-growth companies like Airbnb, Coinbase and Uber. The founders wanted to create the tools that focus us and its team in making progress, not getin the way. Tools that are fast and efficient. Speed and performance were the main things Linear focuses on early on and keep focusing on that.
• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.

Portfolio highlights

• XBuild — The AI-powered estimating platform built for contractor sales teams. Generate professional estimates and proposals in minutes. Close deals on site. See team performance in real time. Try free today.
• Sunlight AI — Sunlight AI builds patient-to-payment operating layer for independent physicians.
• Eezee — Singapore’s first & largest industrial marketplace that connects local suppliers to corporate clients, leveraging technology to help both parties make informed decisions.The company offers a secure platform for buyers and sellers to transact.Our aim is to improve the efficiency of business to business (B2B) transactions. We do this byensuring that the process of selecting and purchasing your supplies becomes quicker, more convenient and transparent. We support local suppliers in establishing their presence online, enabling them to be discovered by corporate organisations.

Portfolio highlights

• 5ire — 5ire is a blockchain network that brings sustainability, technology, and Innovation to build the 5th industrial revolution (5IR). The mission of the 5ire ecosystem is to embed the for-benefit paradigm at the heart of the blockchain, highly incentivize practices that align with the United Nations Sustainable Development Goals (SDGs), facilitate thetransition from the 4IR to 5IR and accelerate the implementation of the UN 2030 Agenda for Sustainable Development. The company's primary offering is 5ireChain, a layer one, sustainability-driven 5th generation blockchain that ensures adherence to the philosophy of 5IR, creating a net positive impact on the planet and serving humanity.
• Polygen — Polygen provides a breath of fresh air in the world of blockchain launchpads. Current solutions all foster innovation on a specific blockchain, but they also look and operate the same. Fueling innovation in this industry requires the removal of all intermediaries and gatekeepers. Additionally, there is a need for more transparency, automatedprocesses, and post-launch support.
• Ignite Tournaments — Empower content creators to launch custom quest lines, track fan engagement, and manage premium subscription communities.

Portfolio highlights

• Splyce Finance — dETF protocol. Permissionless, on-chain index- and yield ETFs.

Portfolio highlights

• Altcoinist — Altcoinist is an interoperable community gating infrastructure that transforms private communities into vibrant on-chain economies by bringing cutting-edge token gating, community staking pools, and enabling new revenue sources for creators and communities.

Portfolio highlights

• Prime Trust — Prime Trust powers innovation in the digital economy by providing fintech and digital asset innovators with financial infrastructure. Our API is customizable whether you're building a crypto exchange or expanding your business with digital assets.
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• Warp — Warp is a payroll and compliance tool that makes it easy for founders to hire, onboard, and pay their employees.
• Wild Moose — Wild Moose helps on-call developers more quickly identify the source of production incidents, by providing a conversational AI trained on their environment. This allows developers to delegate the search through logs and metrics to lightning-fast AI.
• The Wedding Company — The Wedding Company provides the best wedding services in India. Book end-to-end wedding planning services online with us and grab the best deals for your wedding, engagement, reception, and other events.

Portfolio highlights

• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• Composable Corp — Composable Corp is a blockchain financial application developer.
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• Altcoinist — Altcoinist is an interoperable community gating infrastructure that transforms private communities into vibrant on-chain economies by bringing cutting-edge token gating, community staking pools, and enabling new revenue sources for creators and communities.

Portfolio highlights

• Elusiv — Elusiv offers compliance in mind with next-generation privacy solutions for a better Web3.
• TipLink — TipLink helps send crypto with a link. Someone with crypto can create a account and send that link to anyone over any platform. It’s like buying a gift card, connect the client's crypto wallet of choice and create a account by depositing how much they want to send.
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• BRKT — Join the fun on BRKT! Make predictions on sports, pop culture, and more!
• RedStone — RedStone delivers frequently updated, reliable and diverse data for your dApp and smart contracts.

Portfolio highlights

• Altcoinist — Altcoinist is an interoperable community gating infrastructure that transforms private communities into vibrant on-chain economies by bringing cutting-edge token gating, community staking pools, and enabling new revenue sources for creators and communities.

Portfolio highlights

• BRKT — Join the fun on BRKT! Make predictions on sports, pop culture, and more!
• Dinari — Discover Equity Boundless - Simplify everything from equity management and options grant to payroll so that you no longer have to worry about compliance, taxes, or vesting schedules no matter where your employees are.
• BitcoinOS — BitcoinOS is a Decentralized Finance company that builds and develops Bitcoin ecosystem.

Portfolio highlights

• Aire — The income assessment platform that leverages first-party data. Access real-time confidence in the stated income of any consumer.
• Questflow — Questflow Labs seeking to give customers with an all-in-one solution for user intent perception and distribution, AI agentic workflow automation, and human-AI cooperation. Questflow Labs is pioneering a novel approach to decentralized AI agentic workflow.
• Flare — Flare equips your team to shut down cybercrime before it escalates. Detect, prioritize, and remediate external cyber threats with automated Threat Exposure Management.

Portfolio highlights

• Altcoinist — Altcoinist is an interoperable community gating infrastructure that transforms private communities into vibrant on-chain economies by bringing cutting-edge token gating, community staking pools, and enabling new revenue sources for creators and communities.

Portfolio highlights

• Altcoinist — Altcoinist is an interoperable community gating infrastructure that transforms private communities into vibrant on-chain economies by bringing cutting-edge token gating, community staking pools, and enabling new revenue sources for creators and communities.

Portfolio highlights

• Bujeti — Bujeti is the finance control centre for African businesses. Manage expenses, automate payments, and issue corporate cards for total control and visibility.
• FlexDesk — FlexDesk is creating a new evolution of the flexible workspace model. Remote workers use the platform to discover and book a dedicated desk or private office by the day. FlexDesk unlocks this inventory by partnering with office landlords and coworking operators that have furnished, underutilized space.
• SearchEye — Get tech-driven SEO at scale, speed and a fraction of the cost compared to traditional agencies. Acquire PR Mentions, Digital PR and Content.

Portfolio highlights

• Vercel — Vercel gives developers the frameworks, workflows, and infrastructure to build a faster, more personalized web.
• Dataiku — Dataiku is the Platform for AI Success that unites people, orchestration, and governance to turn AI investments into measurable business outcomes.
• HyperComply — HyperComply is the fastest and most accurate way to send and respond to security questionnaires.