Top 50 Startup Investors in Panama (August 2026)

Portfolio highlights

• OP_NET — OPNET is a Bitcoin Layer 1 metaprotocol that enables smart contracts to function directly on the Bitcoin blockchain, without the use of sidechains or Layer 2 solutions.
• Watch.fun — Luxury watch drops. Win a Rolex for as little as $7, drops weekly. Certified by Wristcheck. Backed by @TheSpartanGroup @SolanaVentures @BigBrainVC and more...
• Space — The first leveraged prediction market on @solana

Portfolio highlights

• PERL.eco — The Planetary Ecosystem Registration Ledger will be a dedicated blockchain for real-world ecological assets through tokenizing carbon credits and biodiversity, NFTs and decentralised (DeFi) rewards.
• A-World — Welcome to Animal World, a battle game based on #BNBCHAIN's super metaverse card tower defense. By setting up a hero tower to destroy monsters.
• NeuronX — The First AI-Driven Lending Protocol on @dfinity

Portfolio highlights

• OpenPad AI — OpenPad - The 1st AI Decentralized Launchpad
• Stabble — stabble is a protocol revolutionizing liquidity pools by introducing protocol-managed and arbitrage pools. This allows stabble to tackle critical inefficiencies prevalent within Solana's decentralized exchanges.
• AI Cross Matrix — AI Cross Matrix is a DeFi platform that makes the crypto economy simple by streamlining the exchange process with useful solutions.

Portfolio highlights

• Rivalz Network — Join the connectivity infrastructure between AI Agents, DeFAI and Markets.
• The Arena — A next gen SocialFi app redefining how creators connect, engage, and monetize their content.
• Sigma Computing — Sigma is the only BI analytics tool purpose-built for your cloud data warehouse. Uniquely scalable, with an experience you already know: the spreadsheet.

Portfolio highlights

• EBR Systems — EBR aims for outstanding treatment of cardiac rhythm diseases with an innovative leadless therapy.
• Cardiac Dimensions — Cardiac Dimensions, Inc. is a medical device company developing novel interventional tools for the treatment of heart failure and the related condition of mitral valve regurgitation. Our product, the Carillon® Mitral Contour System®, is a groundbreaking, non-surgical device developed to treat functional mitral valve regurgitation. Our system uses acatheter based approach to reshape the mitral valve and reduce mitral regurgitation.
• Ignite Tournaments — Empower content creators to launch custom quest lines, track fan engagement, and manage premium subscription communities.

Portfolio highlights

• MSafe — MSafe offers the most secure, decentralized, scalable Web3 non-custodial, multi-signature solution built on Move, ideal for dApp developers to use for treasury management, token management, smart contract development, blockchain protocol admin control, live on Aptos
• Polysights — Leverage intelligence to optimize your strategy on @Polymarket
• Turtle Club — Aggregated, diligenced, personalized onchain yield management.

Portfolio highlights

• ShoeFy — ShoeFy is a decentralized project that combines nonfungible tokens (NFTs) and fungible tokens (FTs) on one platform to add new utility layers to NFTs.
• CryptoTanks — CryptoTanks is a play-to-earn platform where every NFT is usable in a gamified DeFi ecosystem. With the tanks, the player earns money and plays games partially owned and operated by their players. Earn tank tokens by playing and use them to decide the future of the game. They offer design and prizes that come with gamified yield farming.
• Astra Guild Ventures — Astra Guild Ventures is one of the world's play-to-earn gaming guilds. Astra Guild Ventures is bridging the gap between players and investors in order to capitalize on the growth of non-traditional games.

Portfolio highlights

• Wizzwoods — 1st pixel farm game integrates interchain capabilities with a SocialFi twist.
• SuperIntent — SuperIntent is a cryptocurrency AI app that streamlines on-chain earning tactics. Developed on a multi-agent framework with abundant yield sources.
• SuperGaming — At SuperGaming, we are putting India on the global gaming map.

Portfolio highlights

• Ignite Tournaments — Empower content creators to launch custom quest lines, track fan engagement, and manage premium subscription communities.

Portfolio highlights

• Alphea — ALPHEA is an AI-native execution OS that awakens intelligence across every surface.
• Dow Protocol — An E-Commerce Financing RWA Platform on @BNBCHAIN, facilitating assets trusted by the world's largest banks. Lead invested by @mhventures @Maple_block
• Fortune Protocol — Fortune Protocol brings the age- old tradition of fortune cookies to the modern prediction market.

Portfolio highlights

• Treyee — Engineering AI solutions and products that empower enterprises to achieve results through adaptive business and personal automation

Portfolio highlights

• Nicegram — Nicegram is a fast, secure and nice messaging app that perfectly includes all Telegram features and offers additional ones which are ideally made for all modern people and businesses.
• Hana Network — Hana Network is a software development company that develops and manages cryptocurrency and blockchain transactions.
• Cluster Protocol — Orchestration layer for autonomous workflows and prompt to dapp browser based IDE on @base all powered by x402 Backed by @daofive and @papervc

Portfolio highlights

• Bluwhale — Unlock Web3 Wallet Potential with AI Insights. Supercharge Your Business Growth
• BluWhale — Premium domain available for acquisition.
• Sorted Wallet — Sorted Wallet simplifies crypto transactions for feature phones in emerging markets.

Portfolio highlights

• Treyee — Engineering AI solutions and products that empower enterprises to achieve results through adaptive business and personal automation

Portfolio highlights

• AEON — Powering #agenticeconomy #x402 | AEON is settlement layer bridging autonomous AI interactions (A2A & A2M) with real-world value flows. Backed by @yzilabs $AEON
• KOR Protocol — KOR Protocol is a decentralized intellectual property (IP) infrastructure designed to empower creators, protect rights, and enable seamless collaboration and monetization of IP assets across various industries, including music, film, TV, gaming, and art. Backed by notable entities like Animoca Brands, Republic, Niantic, Sfermion, Solana, andprominent creators such as Black Mirror, Disclosure, deadmau5, and Richie Hawtin, KOR leverages blockchain, AI, and DeFi to offer a transparent, efficient, and scalable environment for IP expansion.
• Limited — Secure your treasury and scale your business globally with a truly self-custodial account that only you control. No banks. No middlemen.

Portfolio highlights

• Meta Pool — Meta Pool is a multi-chain, liquid staking-based ecosystem with Vote-to-Earn DAO governance.
• Amnis Finance — Stake APT on the best liquid staking protocol on Aptos to receive daily rewards with an attractive APR of 2%.
• Velvet Capital — Trade any crypto onchain - spot and perpetuals across 7 chains with AI-powered routing. Non-custodial DeFi trading terminal + AI trading bot. 100K+ traders.

Portfolio highlights

• SnakeLite — 10-min prediction markets on Hyperliquid whale positions, BTC and ETH. Predict up or down. Settle onchain. From the 100M+ download SnakeLite game.
• Sophon — Soph(+) is a tech studio building novel consumer experiences in crypto and ai. we build, own, and ship our own products, starting with pyre.
• A.A.A C(H+A)RM — AAA C(H+A)RM (Autonomous AI Agents Launchpad & Layer3) is the first AI-first, agent-focused orchestration platform.

Portfolio highlights

• Orix AI — Orix is an on-chain AI engineer that writes, audits and ships smart contracts in seconds. Build BEP-20 tokens, DeFi and more on BNB Chain.
• ChimpX AI — ChimpX AI is an AI-powered decentralized finance (DeFi) superapp designed to simplify crypto trading, cross-chain asset management, and blockchain interactions through natural language commands. The platform focuses on making complex DeFi operations accessible to everyday users by combining artificial intelligence, automation, and gaslesstransactions into a single interface.
• Harry Howard — An AI-powered incubation platform that transforms Web3 innovation from concept to launch through intelligent automation and community governance. Visit our X Visit our Launchpad

Portfolio highlights

• SQR3D — Transform your idea into 3D assets at scale. Smart Contract Automation for 3D Designs with SQR3D.
• Reitio Protocol — We’re creating an effortless way for everyone to create custom metaverse assets visually via an intuitive and codeless templates-based design toolkit, introducing reitio protocol.
• Genesis Shards — Crafting a whole new suite of NFT powered products across multiple blockchains

Portfolio highlights

• Capx — Capx's mission is to accelerate the flow of capital through the private markets, thereby enhancing global capital allocation. With secondary market and enterprise solutions, Capx combines high-quality collections of opportunities with efficient access for institutions and individual investors.
• DeepSafe — The world's first Cryptographic Random AI Verification Network for trustless verification of any on-chain and off-chain messages.
• aPriori — aPriori is a monad-native MEV infrastructure and liquid staking mechanism developed for parallel executions.

Portfolio highlights

• Mudafy — Mudafy is a tech-enabled real estate broker for LatAm.
• Klaimee — Certify your AI agent. Get guaranteed. Risk evaluation, certification badge, financial guarantee, and liability insurance for AI agents.
• dili — Dili is a deal platform built for venture funds and private equity. We use AI to contextualize new deals and help you make better decision faster.

Portfolio highlights

• DHL — DHL is a division of the German logistics company Deutsche Post DHL that provides international express mail services. Deutsche Post is a large-scale logistics company operating around the world. DHL provides world market services both in sea and air mail.DHL was primarily interested in offshore and inter-continental deliveries, but the successof FedEx prompted its own intra-U.S. expansion starting in 1983. DHL aggressively expanded to countries that could not be served by any other delivery service, including the Soviet Union, Eastern Bloc, Iraq, Iran, China, Vietnam, and North Korea.Deutsche Post then effectively absorbed DHL into its Express division, while expanding the use of the DHL brand to other Deutsche Post divisions, business units and subsidiaries.Originally founded in 1969 to deliver documents between San Francisco and Honolulu, the company expanded its service throughout the world by the late 1970s. DHL was founded in 1969 and is based in Bonn.
• ShoeFy — ShoeFy is a decentralized project that combines nonfungible tokens (NFTs) and fungible tokens (FTs) on one platform to add new utility layers to NFTs.

Portfolio highlights

• myco — myco is a content streaming super dApp that smoothly integrates AVOD and SVOD capabilities into a decentralized ecosystem.
• Metametaverse — Discover the future of virtual worlds with our metaverse platform. Explore, create and monetize your own metaverse experiences in a seamless and secure manner. Join the cosmic system of metaverses today.
• Ignite Tournaments — Empower content creators to launch custom quest lines, track fan engagement, and manage premium subscription communities.

Portfolio highlights

• Mason America, Inc. — Mason is the device innovation platform for product leaders who dare to deliver the next innovation in their field.
• Mudafy — Mudafy is a tech-enabled real estate broker for LatAm.
• Gecko Robotics — To collect and make useful physical data in order to protect civilization's most critical infrastructure

Portfolio highlights

• GAMES.GG — Discover 1,500+ games with honest reviews, expert guides, and daily gaming news across PC, console, and mobile. Find your next favorite game on Steam, Epic Games, PlayStation, Xbox, and Nintendo.
• Sumer Money — Sumer Money is a cross-chain synthetic assets protocol that enables composable Defi across blockchains.
• SYNTRA — Live AI trading system. Real-time execution, risk-managed positions, public trade feed. Signals, performance, transparency.

Portfolio highlights

• 3VO — Bring Your Business On-chain. The easiest way to launch, grow, and own your brand with AI + Web3 tools - all in one simple, social platform.

Portfolio highlights

• Vangrid — Vangrid operates as a decentralized physical infrastructure network.
• Dow Protocol — An E-Commerce Financing RWA Platform on @BNBCHAIN, facilitating assets trusted by the world's largest banks. Lead invested by @mhventures @Maple_block
• Ceramic Network — We've joined @textileio to build the first open intelligence network for AI agents. Follow us there.

Portfolio highlights

• Altcoinist — Altcoinist is an interoperable community gating infrastructure that transforms private communities into vibrant on-chain economies by bringing cutting-edge token gating, community staking pools, and enabling new revenue sources for creators and communities.

Portfolio highlights

• Prime Trust — Prime Trust powers innovation in the digital economy by providing fintech and digital asset innovators with financial infrastructure. Our API is customizable whether you're building a crypto exchange or expanding your business with digital assets.
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• Warp — Warp is a payroll and compliance tool that makes it easy for founders to hire, onboard, and pay their employees.
• Wild Moose — Wild Moose helps on-call developers more quickly identify the source of production incidents, by providing a conversational AI trained on their environment. This allows developers to delegate the search through logs and metrics to lightning-fast AI.
• The Wedding Company — The Wedding Company provides the best wedding services in India. Book end-to-end wedding planning services online with us and grab the best deals for your wedding, engagement, reception, and other events.

Portfolio highlights

• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• Composable Corp — Composable Corp is a blockchain financial application developer.
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• Altcoinist — Altcoinist is an interoperable community gating infrastructure that transforms private communities into vibrant on-chain economies by bringing cutting-edge token gating, community staking pools, and enabling new revenue sources for creators and communities.

Portfolio highlights

• Elusiv — Elusiv offers compliance in mind with next-generation privacy solutions for a better Web3.
• TipLink — TipLink helps send crypto with a link. Someone with crypto can create a account and send that link to anyone over any platform. It’s like buying a gift card, connect the client's crypto wallet of choice and create a account by depositing how much they want to send.
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• BRKT — Join the fun on BRKT! Make predictions on sports, pop culture, and more!
• RedStone — RedStone delivers frequently updated, reliable and diverse data for your dApp and smart contracts.

Portfolio highlights

• Altcoinist — Altcoinist is an interoperable community gating infrastructure that transforms private communities into vibrant on-chain economies by bringing cutting-edge token gating, community staking pools, and enabling new revenue sources for creators and communities.

Portfolio highlights

• BRKT — Join the fun on BRKT! Make predictions on sports, pop culture, and more!
• Dinari — Discover Equity Boundless - Simplify everything from equity management and options grant to payroll so that you no longer have to worry about compliance, taxes, or vesting schedules no matter where your employees are.
• BitcoinOS — BitcoinOS is a Decentralized Finance company that builds and develops Bitcoin ecosystem.

Portfolio highlights

• Aire — The income assessment platform that leverages first-party data. Access real-time confidence in the stated income of any consumer.
• Questflow — Questflow Labs seeking to give customers with an all-in-one solution for user intent perception and distribution, AI agentic workflow automation, and human-AI cooperation. Questflow Labs is pioneering a novel approach to decentralized AI agentic workflow.
• Flare — Flare equips your team to shut down cybercrime before it escalates. Detect, prioritize, and remediate external cyber threats with automated Threat Exposure Management.

Portfolio highlights

• Altcoinist — Altcoinist is an interoperable community gating infrastructure that transforms private communities into vibrant on-chain economies by bringing cutting-edge token gating, community staking pools, and enabling new revenue sources for creators and communities.

Portfolio highlights

• Altcoinist — Altcoinist is an interoperable community gating infrastructure that transforms private communities into vibrant on-chain economies by bringing cutting-edge token gating, community staking pools, and enabling new revenue sources for creators and communities.

Portfolio highlights

• Bujeti — Bujeti is the finance control centre for African businesses. Manage expenses, automate payments, and issue corporate cards for total control and visibility.
• FlexDesk — FlexDesk is creating a new evolution of the flexible workspace model. Remote workers use the platform to discover and book a dedicated desk or private office by the day. FlexDesk unlocks this inventory by partnering with office landlords and coworking operators that have furnished, underutilized space.
• SearchEye — Get tech-driven SEO at scale, speed and a fraction of the cost compared to traditional agencies. Acquire PR Mentions, Digital PR and Content.

Portfolio highlights

• 54gene — 54gene is a healthcare startup unlocking the African genome to fuel genetic research and development that may lead to new discoveries and benefit all populations.54gene was founded in 2019 by Dr. Abasi Ene-Obong to address the significant gap in the global genomics market: Nearly 90% of genetic material used in pharmaceutical research iscaucasian. Only 2% is African, despite the fact that Africans and people of African ancestry are more genetically diverse than all other world populations combined. As a result, pharmaceutical research and development is lacking the diverse data that may hold the key to medical discoveries and new healthcare solutions.
• Betterhalf — Best matrimony app in India with AI matchmaking. Get compatible life partner from lakhs of genuine, Govt ID and selfie verified profiles of brides & grooms. Download Betterhalf marriage app now!
• SOS Hydration — Rescue yourself from dehydration with SOS, doctor formulated rapid hydration with 80x less sugar than sports drinks and only 3g carbs and 10 calories.

Portfolio highlights

• Vercel — Vercel gives developers the frameworks, workflows, and infrastructure to build a faster, more personalized web.
• Dataiku — Dataiku is the Platform for AI Success that unites people, orchestration, and governance to turn AI investments into measurable business outcomes.
• HyperComply — HyperComply is the fastest and most accurate way to send and respond to security questionnaires.

Portfolio highlights

• Kin Health — Kin records doctor visits, turns them into clear summaries and next steps, and helps your care circle stay aligned.
• Jimini Health — Jimini’s mission is to radically improve the efficacy of mental health care across the world. Jimini has developed a novel care model that combines teletherapy sessions with personalized AI support. With Jimini, your therapy care team includes your licensed clinician and Sage, your always-available AI therapy assistant, who work together to helpyou achieve your goals.Founded in 2023 by a team of seasoned AI and biotech entrepreneurs, health tech veterans, and psychology researchers, Jimini puts science and tech first, using safe, purpose-built patient-facing technology that works exclusively under clinical oversight and high safety standards.World leaders in psychology designed Jimini’s care model to ensure that every part of the patient's journey is clinically beneficial. Jimini does not believe that LLMs should replace clinicians; rather, AI will help therapists deliver higher-quality care and focus on the most complex parts of their job. Jimini’s care model is first and foremost led by excellent clinicians.Jimini is committed to improving mental health quality and creating radically better, more modern, and clinically efficacious mental health experiences for patients.
• Qualified Health — Discover the Infrastructure for enforceable governance, agent creation, and post-deployment monitoring for Generative AI in healthcare

Portfolio highlights

• BAYZ — NFT Gaming Startup | Esports & Content Community HUB | #PlayToEarn
• UNXD — UNXD is a curated NFT marketplace for the best of digital luxury and culture. Featuring NFTs from Dolce&Gabbana, Jacob & Co., and more.
• Mon Studios — An indie game development studio

Portfolio highlights

• Capx — Capx's mission is to accelerate the flow of capital through the private markets, thereby enhancing global capital allocation. With secondary market and enterprise solutions, Capx combines high-quality collections of opportunities with efficient access for institutions and individual investors.
• Noodles Finance — The no-brainer trading platform for Sui.
• YOAKE Entertainment — YOAKE Entertainment is a music studio that specializes in the planning, production, and development of entertainment content.

Portfolio highlights

• Delabs Games — At Delabs Games, we want to create fun games that last a thousand years.
• PublicAI — PublicAI is a Web3 distributed AI training network that helps people to earn rewards by contributing data work.
• Power Protocol — The ecosystem for blockchain entertainment. Fueled by $POWER. Launch Partner: @Fableborne Power Up Your Play

Portfolio highlights

• Nexio — Making Bitcoin Productive
• Turtle Club — Aggregated, diligenced, personalized onchain yield management.
• Neutral Trade — Quant Strategies Marketplace backed by @incubator @ergonia_ | Official Links: https://t.co/LducMMG0ly

Portfolio highlights

• Starbots — Starbots is Solana's first-ever battle NFT game.
• Linear — Linear allows the user to manage software development and track bugs. Built for speed and efficiency.The founders started Linear from their own frustrations building software projects in successful high-growth companies like Airbnb, Coinbase and Uber. The founders wanted to create the tools that focus us and its team in making progress, not getin the way. Tools that are fast and efficient. Speed and performance were the main things Linear focuses on early on and keep focusing on that.
• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.

Portfolio highlights

• Kapkap — Kapkap is a web3 platform that uses AI for attention based value distribution in gaming.
• SuperIntent — SuperIntent is a cryptocurrency AI app that streamlines on-chain earning tactics. Developed on a multi-agent framework with abundant yield sources.
• Inference Labs — AI hyperscale on decentralized networks - We provide certainty for on-chain AI