# Top 50 Biotechnology Startup Investors in United States in June 2026 ## SOSV - Type: VC Fund - Location: Princeton, New Jersey, United States - Relevant deals: 124 - Stages: Seed, Convertible Note, Pre-Seed - Focus: Biotechnology, Health Care, Software SOSV is a global, deep tech venture capital firm that operates the HAX and IndieBio startup development programs focused on human and planetary health. SOSV invests $500,000 in startups at their inception as they onboard either HAX or IndieBio for a 4-6 month period designed to accelerate the raise of their next institutional round. SOSV joins thelater rounds of HAX and IndieBio graduates. HAX, based in a 35,000 sq ft facility in Newark, NJ, is equipped with machine tools, 3D printers, chemical, electrical and mechanical engineering labs, as well as on-staff engineering and design experts. SOSV's IndieBio has locations in NYC and San Francisco, both of which offer extensive services and facilities to founders including on-site BSL-2 labs, well equipped lab benches and hoods, and advanced lab equipment, such as chromatography equipment. ## ARCH Venture Partners - Type: VC Fund - Location: Chicago, Illinois, United States - Relevant deals: 117 - Stages: Series A, Series B, Series C - Focus: Biotechnology, Health Care, Therapeutics ARCH Venture Partners provides seed / early stage venture capital for technology firms in information technology, life sciences, and physical sciences ## Alexandria Venture Investments - Type: VC Fund - Location: Pasadena, California, United States - Relevant deals: 98 - Stages: Series A, Series B, Seed - Focus: Biotechnology, Health Care, Therapeutics Alexandria Venture Investments is a venture capital firm that develops work in real estate technology, and healthcare sectors. The company's strategic venture capital platform is Alexandria Venture Investments. Since its inception in 1996, the company has invested in disruptive life science, agrifood tech, and technology companies that aredeveloping transformative new modalities and platforms to meaningfully improve human health. ## OrbiMed - Type: VC Fund - Location: New York, New York, United States - Relevant deals: 84 - Stages: Series B, Series A, Series C - Focus: Biotechnology, Health Care, Medical Leading Global Healthcare Platform with Deep Proprietary Resources and Global Industry Coverage. ## Atlas Venture - Type: VC Fund - Location: Cambridge, Massachusetts, United States - Relevant deals: 72 - Stages: Series A, Series B, Series C - Focus: Biotechnology, Health Care, Therapeutics Atlas Venture is an early-stage venture capital firm that creates and invests in biotech startup companies led by promising entrepreneurs focusing on life sciences innovation. Its seed-led venture creation strategy rigorously selects and focuses investment on compelling opportunities to build scalable businesses and realize value. ## New Enterprise Associates - Type: VC Fund - Location: Menlo Park, California, United States - Relevant deals: 67 - Stages: Series A, Series B, Series C - Focus: Software, Health Care, Biotechnology Foundational partners to ambitious founders at every stage of company-building. ## Versant Ventures - Type: VC Fund - Location: Menlo Park, California, United States - Relevant deals: 64 - Stages: Series A, Series B, Series C - Focus: Biotechnology, Health Care, Medical Versant partners with exceptional entrepreneurs to build and fund breakthrough biotechnology companies around the globe. ## Polaris Partners - Type: VC Fund - Location: Boston, Massachusetts, United States - Relevant deals: 63 - Stages: Series B, Series A, Series C - Focus: Biotechnology, Health Care, Medical Polaris Partners invests in healthcare and biotechnology companies. Their healthcare portfolio companies' care delivery models include digital health, consumer-centric businesses, patient-provider solutions, data science, and analytics. Their life sciences and biotechnology portfolio companies focus on molecules and platforms, therapeutics,and genomics. ## Innova Memphis - Type: VC Fund - Location: Memphis, Tennessee, United States - Relevant deals: 62 - Stages: Seed, Pre-Seed - Focus: Health Care, Medical, Medical Device Founded in 2007 by the Memphis Bioworks Foundation, Innova is a pre-seed, seed and early-stage investor focused on starting and funding high-growth companies in the Biosciences, Technology and AgBio fields across the state of Tennessee. Innova links capital with great ideas to create groundbreaking products and services.At Innova we invest instart-up companies, help them grow, and then assist them in linking with established corporations for licensing, buy-outs or further investments. We provide the synergy of experienced management, market expertise and venture capital to accelerate the development of new products and services into viable business units that can stand on their own and then take their place with a mature market leader, if desired.Whether an innovation is still on the drawing board or stalled in the market place the Innova staff has the expertise, skills, and experience to envision and create a functioning business unit that is prepared to thrive in the market place. Technical know-how, market-proven staffing, and "just-right" funding assure the greatest chance possible for success. ## Third Rock Ventures - Type: VC Fund - Location: Boston, Massachusetts, United States - Relevant deals: 62 - Stages: Series A, Series B, Series C - Focus: Biotechnology, Health Care, Therapeutics Third Rock Ventures invests in transformational life science companies that show high growth potential and are well-positioned to make a difference in the marketplace. Third Rock Ventures believes in the companies we start and makes significant initial investments, which are frequently supplemented by strategic collaborations, to help our firmsprogress in life-changing medicines, technologies, and diagnostics. ## 5AM Ventures - Type: VC Fund - Location: Menlo Park, California, United States - Relevant deals: 61 - Stages: Series A, Series B, Series C - Focus: Biotechnology, Health Care, Therapeutics 5AM Ventures is a venture capital firm that offers seed- and early-stage investments to its clients. The company’s client portfolio consists of firms in the biopharmaceutical, life sciences, medical technology, and research instrument industries. 5AM Ventures was founded in 2002 by John Diekman and Andrew Schwab and is based in California. ## Khosla Ventures - Type: VC Fund - Location: Menlo Park, California, United States - Relevant deals: 61 - Stages: Series A, Series B, Seed - Focus: Software, Artificial Intelligence, Health Care Khosla Ventures is a venture capital firm that invests in early- to late-stage companies across sectors like AI, healthcare, sustainability, and consumer technology. It manages multiple funds, focusing on startups with innovative technologies or business models. The firm primarily targets sectors like AI, climate tech, digital health, and medtech,offering strategic support to help build long-lasting companies. ## MPM Capital - Type: VC Fund - Location: Cambridge, Massachusetts, United States - Relevant deals: 60 - Stages: Series A, Series B, Series C - Focus: Biotechnology, Health Care, Pharmaceutical Powering Breakthroughs in Life Sciences ## RA Capital Management - Type: VC Fund - Location: Boston, Massachusetts, United States - Relevant deals: 56 - Stages: Series B, Series C, Post-IPO Equity - Focus: Biotechnology, Health Care, Therapeutics RA Capital Management is an investment advisor based in Boston specializing in the life-sciences and drug development sectors. The company's team has been investing since 2002 and is comprised of professionals with training in biology, chemistry, and medicine and also has industry and business development experience at the executive and boardlevels. The company invests in companies with promising technologies and products. ## F-Prime - Type: VC Fund - Location: Cambridge, Massachusetts, United States - Relevant deals: 55 - Stages: Series A, Series B, Series C - Focus: Health Care, Biotechnology, Medical F-Prime Capital is a global venture capital firm investing in healthcare and technology, with a heritage that spans four decades. ## Alumni Ventures - Type: VC Fund - Location: Manchester, New Hampshire, United States - Relevant deals: 50 - Stages: Seed, Series A, Series B - Focus: Software, Artificial Intelligence, Information Technology Access curated startup investment opportunities and diversified venture capital exposure designed for accredited investors. ## Canaan Partners - Type: VC Fund - Location: Menlo Park, California, United States - Relevant deals: 49 - Stages: Series A, Series B, Series C - Focus: Software, Biotechnology, Health Care Canaan is an early stage venture capital firm that invests in entrepreneurs with visionary ideas. With $5B under management, a diversified fund and over 190 exits to date, Canaan has invested in some of the world's leading technology and healthcare companies over the past 30 years. Canaan’s focus areas include fintech, enterprise/cloud,marketplaces, frontier tech, biopharma, digital health, and medtech. ## BioAdvance - Type: VC Fund - Location: Philadelphia, Pennsylvania, United States - Relevant deals: 48 - Stages: Seed, Series A - Focus: Biotechnology, Health Care, Medical BioAdvance actively invests venture capital in therapies, medical devices, research tools, diagnostics and health IT in the Mid-Atlantic region. ## The Column Group - Type: VC Fund - Location: San Francisco, California, United States - Relevant deals: 46 - Stages: Series A, Series B, Series C - Focus: Biotechnology, Health Care, Therapeutics The Column Group (TCG) is a venture ecosystem dedicated to fueling scientific innovation in the life sciences industry. ## Andreessen Horowitz - Type: VC Fund - Location: Menlo Park, California, United States - Relevant deals: 46 - Stages: Series A, Seed, Series B - Focus: Software, Information Technology, Artificial Intelligence Andreessen Horowitz (a16z) is a venture capital firm in Silicon Valley, California, investing in bold founders, innovators, and entrepreneurs building the future through technology. ## KdT Ventures - Type: VC Fund - Location: Austin, Texas, United States - Relevant deals: 44 - Stages: Seed, Series A, Series B - Focus: Biotechnology, Health Care, Medical KdT Ventures is the standard for early-stage frontier science investing. ## Google Ventures - Type: VC Fund - Location: Mountain View, California, United States - Relevant deals: 44 - Stages: Series A, Series B, Seed - Focus: Software, Health Care, Biotechnology GV supports innovative founders moving the world forward. ## Novartis Venture Fund - Type: VC Fund - Location: Basel, Basel-Stadt, Switzerland - Relevant deals: 43 - Stages: Series B, Series A, Series C - Focus: Biotechnology, Health Care, Therapeutics Learn about the approach the Novartis Venture Fund takes to investing in innovative life science companies developing biotechnology and biopharmaceutical therapeutics that address unmet patient needs. ## Lux Capital - Type: VC Fund - Location: New York, New York, United States - Relevant deals: 42 - Stages: Series A, Seed, Series B - Focus: Software, Artificial Intelligence, Health Care Lux Capital manages over $5 billion in assets focused on founding, seed, early-stage, and growth investments at the intersection of technology and the sciences. Lux takes an active role in helping entrepreneurs build successful businesses in high-growth sectors. Its investment team has built over 20 companies from scratch. Lux's investmentstrategy ensures portfolio companies are better connected, have a deeper insight, and command industry leadership faster than their competitors. ## DCVC - Type: VC Fund - Location: San Francisco, California, United States - Relevant deals: 41 - Stages: Seed, Series A, Series B - Focus: Software, Artificial Intelligence, Machine Learning We are deep tech venture capital. ## Connecticut Innovations - Type: VC Fund - Location: Rocky Hill, Connecticut, United States - Relevant deals: 41 - Stages: Seed, Series A - Focus: Health Care, Biotechnology, Software At Connecticut Innovations, we see venture capital the way you see your business. Like no one else. We invest in innovative biotech, IT, and other industries. ## Fifty Years - Type: VC Fund - Location: San Francisco, California, United States - Relevant deals: 41 - Stages: Seed, Series A, Series B - Focus: Biotechnology, Health Care, Artificial Intelligence WE BACK HEROES using technology to solve the world's biggest problems ## Dolby Family Ventures - Type: VC Fund - Location: San Francisco, California, United States - Relevant deals: 40 - Stages: Series A, Seed, Series B - Focus: Biotechnology, Health Care, Therapeutics Investing in early-stage companies solving the biggest science and engineering challenges since 2014. ## Mission BioCapital - Type: VC Fund - Location: Cambridge, Massachusetts, United States - Relevant deals: 40 - Stages: Series A, Series B - Focus: Biotechnology, Health Care, Therapeutics Mission BioCapital is a life science venture capital firm that invests in early-stage companies. The company leadership team has a long history together, investing in and launching dozens of early-stage life science companies. They are located in regions with a rich concentration of research, discovery, and venture capital investment, and they areknown by leaders of portfolio companies for the expertise and deep support they provide. ## Hatteras Venture Partners - Type: VC Fund - Location: Durham, North Carolina, United States - Relevant deals: 39 - Stages: Series A, Series B, Series C - Focus: Health Care, Biotechnology, Medical Hatteras Venture Partners is a venture capital firm based in Research Triangle Park, NC, with a focus on biopharmaceuticals, medical devices, diagnostics, and related opportunities in human medicine. Founded in 2000, the firm consists of an experienced team with a broad and complementary skill set that is particularly relevant to buildingsuccessful new biomedical companies. The Hatteras Venture Partners team brings operational experience, a successful track record, and a proven ability to enhance the value of the companies in which it invests. With three funds, the firm has more than $120 million under management. ## Frazier Healthcare Partners - Type: VC Fund - Location: Seattle, Washington, United States - Relevant deals: 38 - Stages: Series B, Series A, Post-IPO Equity - Focus: Biotechnology, Health Care, Therapeutics With its purpose-driven culture and deep industry expertise, Frazier Healthcare is the preferred partner to profitable healthcare companies. ## Sofinnova Investments - Type: VC Fund - Location: Menlo Park, California, United States - Relevant deals: 37 - Stages: Series B, Series A, Series C - Focus: Biotechnology, Health Care, Pharmaceutical Sofinnova deploys human and financial capital to turn dreams into drugs. We are a clinical-stage biopharmaceutical venture capital firm with approximately $2B in assets under management and committed capital. ## Northpond Ventures - Type: VC Fund - Location: Bethesda, Maryland, United States - Relevant deals: 37 - Stages: Series A, Series B, Series C - Focus: Biotechnology, Health Care, Life Science Northpond Ventures is a science-driven venture capital firm headquartered in Bethesda, Maryland. Our mission is to build a better tomorrow. Our investments are focused on life sciences, technology, and affiliated industries. ## Pfizer Venture Investments - Type: VC Fund - Location: New York, New York, United States - Relevant deals: 37 - Stages: Series B, Series A, Series C - Focus: Biotechnology, Health Care, Therapeutics Pfizer Venture Investments is a corporate venture capital firm that invests in areas of current or future strategic interest to Pfizer. It aims to remain at the forefront of life science advances. It identifies and invests in emerging companies that are developing transformative medicines and technologies that have the potential to enhance Pfizer’spipeline and shape the future of its industry. ## Civilization Ventures - Type: VC Fund - Location: San Francisco, California, United States - Relevant deals: 36 - Stages: Seed, Series A, Series B - Focus: Biotechnology, Health Care, Medical DIGITAL HEALTH / AI DIGITAL HEALTH / AI GENE / CELL THERAPIES NASDAQ: RCKT GENE / CELL THERAPIES NASDAQ: RCKT GENOMICS / DIAGNOSTICS GENOMICS / DIAGNOSTICS SYNTHETIC ## Novo Holdings - Type: VC Fund - Location: Hellerup, Hovedstaden, Denmark - Relevant deals: 35 - Stages: Series A, Series B, Series C - Focus: Biotechnology, Health Care, Medical Novo Holdings is a world-leading life science investor with a focus on creating long-term value. ## Boston Harbor Angels - Type: VC Fund - Location: Boston, Massachusetts, United States - Relevant deals: 35 - Stages: Angel, Seed, Series A - Focus: Biotechnology, Health Care, Medical Device Boston Harbor Angels is a group of proven business leaders interested in investing a portion of their assets in high growth, early stage companies. The group was formed in February 2004 and since then has made a number of investments in companies in medical devices, IT, consumer products, business products, specialty materials, Internet, aviation,etc. They believe they contribute more than money to the companies they fund and welcome the opportunity to work with entrepreneurs open to take advice, yet having the smarts and determination to make the company successful.Their focus is on early stage companies usually looking to raise $250K to $1.5M, where they can fund a portion of the round and syndicate the deal with other angel groups or early stage venture funds. The stage of the company should be close to commercialization, while the company should have a clear and defensible competitive advantage. They are looking for capital efficient businesses, which can reach profitability with less than $5M of equity investment and provide at least 10X return on the investment within 5 years.They do not invest as a fund - each of their members makes his or her individual investment decision but they collaborate in Due Diligence. They have a deep expertise in the life sciences field where they usually take the position of a lead investor, but are open to any opportunities that can make a strong business case. In some cases they prefer to be the follow on investor if they cannot identify a person with strong expertise within their group.The group’s strategy is directed by an executive committee which consists of 8 people elected by the group: Wayne Griffith (chairman), Bill McPhee, Henry Kay, Jay Schwartz (membership director), Steve Andress, Peter Miller, Don Freeman and Mic Williams (president and founder). The group’s day-to-day operations are managed by Boris Batchvarov (managing director).They receive 20-30 business summaries each month, out of which they select 8 companies to make a personal presentation to their screening committee. The screening committee consists of volunteers from the group. The presentations are 10 min long followed by 10 min Q&A. 4 of the companies are invited to present to the whole group, with the idea to get the people interested and decide to perform a Due Diligence with the companies before making an investment. ## Life Science Angels - Type: VC Fund - Location: Sunnyvale, California, United States - Relevant deals: 35 - Stages: Seed, Series A - Focus: Biotechnology, Health Care, Medical Life Science Angels, Inc. (LSA) is the premier angel investment group focused solely on healthcare investing, including medical devices, diagnostics, pharmaceuticals, biotechnology, and digital health. ## Founders Fund - Type: VC Fund - Location: San Francisco, California, United States - Relevant deals: 34 - Stages: Series A, Seed, Series B - Focus: Software, Health Care, Information Technology Founders Fund is a San Francisco based venture capital firm investing in companies building revolutionary technologies. ## Omega Funds - Type: VC Fund - Location: Boston, Massachusetts, United States - Relevant deals: 34 - Stages: Series A, Series B, Series C - Focus: Biotechnology, Health Care, Therapeutics We aim to invest in exceptional founders and entrepreneurs and impactful products and platforms across multiple therapeutic areas. ## Domain Associates - Type: VC Fund - Location: San Diego, California, United States - Relevant deals: 33 - Stages: Series B, Series C, Series A - Focus: Biotechnology, Health Care, Medical INVESTMENT ADVISORS TO THE FIRST VC FUND DEDICATED TO BIOTECH INVESTMENT MANAGER OF 9 SUBSEQUENT BIOTECH VC FUNDS ## Amgen Ventures - Type: VC Fund - Location: San Francisco, California, United States - Relevant deals: 33 - Stages: Series B, Series A, Series C - Focus: Biotechnology, Health Care, Therapeutics Amgen Ventures is a venture capital investment arm of Amgen Inc. specializing in investments in early and later stage companies. The firm primarily invests in the biotechnology sector with a focus on discovering and developing human therapeutics with a focus on oncology, inflammation, hematology, nephrology, metabolic disorders, neuroscience, andcardiovascular therapeutics. In oncology and hematology it focuses on novel therapeutics including signal transduction, cell cycle, and apoptosis; hematopoiesis including anemia, neutropenia, and stem cell mobilization; and supportive care including mucositis and cachexia. In nephrology the firm focuses on renal failure and hyperparathyroidism. For inflammation the firm focuses on rheumatoid arthritis, psoriasis, systemic lupus erythematosus, inflammatory bowel disease, multiple sclerosis, asthma and COPD, and osteoarthritis. Under cardiovascular, it focuses on acute coronary syndromes, dyslipidemia, and heart failure and under metabolic disorders it focuses on diabetes, metabolic syndrome, and osteoporosis. The focus on neuroscience included pain including neuropathic and inflammatory, alzheimer's disease, parkinson's disease, sleep disorder, cognition, and schizophrenia. In discovery research and technology the firm focuses on early-stage drug discovery collaborations, innovative chemical entity collections, diagnostics and biomarkers, novel antibody platforms, assay biologicals and devices, and target-focused structural biology and computational tools. It primarily invests in the North America, Europe, and the United Kingdom. The firm typically invests between $2 million and $3 million per transaction and may invest up to $10 million per company. It prefers to have an ownership stake of less than 15 % in its portfolio companies. Amgen Ventures was founded in 2004 and is based in San Francisco, California with additional offices in Seattle, Washington; Thousand Oaks, California; and Cambridge, Massachusetts. ## Gaingels - Type: VC Fund - Location: New York, New York, United States - Relevant deals: 32 - Stages: Seed, Series A, Series B - Focus: Software, Health Care, Artificial Intelligence Gaingels is a venture investment syndicate in service of the LGBT+ community and its allies, investing in companies with LGBT+ founders and C-suite leaders at all stages of growth, as well as in more established companies resolved on building more inclusive teams, with a global portfolio of 130+ companies and $70M in deployed investment capital todate. The Gaingels network also actively supports its portfolio in identifying and recruiting diverse talent to their C-suite and board leadership teams and fosters a vibrant global community of industry leaders, investors, operators, and entrepreneurs who share a common goal for positive social change through business and successful investments. ## Illumina Ventures - Type: VC Fund - Location: Foster City, California, United States - Relevant deals: 32 - Stages: Series A, Series B, Series C - Focus: Biotechnology, Health Care, Medical We invest in companies that are advancing the field of genomics and pioneering new applications in healthcare, agriculture, environmental science, and personal ## Refactor - Type: VC Fund - Location: Burlingame, California, United States - Relevant deals: 32 - Stages: Seed, Series A, Series B - Focus: Health Care, Biotechnology, Medical Refactor Capital is an early-stage venture capital firm that invests in founders solving fundamental human problems. ## Flagship Pioneering - Type: VC Fund - Location: Cambridge, Massachusetts, United States - Relevant deals: 32 - Stages: Series B, Series C, Series A - Focus: Biotechnology, Health Care, Medical We create breakthroughs in human health and sustainability and build bioplatform companies . Companies founded ## Takeda Ventures - Type: VC Fund - Location: San Diego, California, United States - Relevant deals: 31 - Stages: Series A, Series B - Focus: Biotechnology, Health Care, Therapeutics Takeda Ventures, Inc. (TVI) is the corporate investment arm of Takeda Pharmaceutical Company Limited (TPC). TVI was founded in 2001 and invests in current and future areas of interest for TPC. They are based alongside Takeda’s R&D sites in Cambridge, MA, and San Diego, CA. As a strategic investor, TVI aims to provide support and guidance toentrepreneurs and early-stage companies driving concepts through clinical proof of concept. They also strive to forge active, collaborative interactions that result in synergies with Takeda's considerable R&D resources. Their goal is to build a portfolio of strategic investments, with an immediate emphasis on oncology, gastroenterology, neuroscience, and rare diseases. ## North Carolina Biotechnology Center - Type: VC Fund - Location: Alexander, North Carolina, United States - Relevant deals: 31 - Stages: Debt Financing, Grant - Focus: Biotechnology, Health Care, Medical The North Carolina Biotechnology Center is a private, non-profit corporation funded by the N.C. General Assembly to strengthen biotechnology research, business and education statewide. The Center is not a site for laboratory research; it works to support job creation in the biotechnology industry. ## Vivo Capital - Type: VC Fund - Location: Palo Alto, California, United States - Relevant deals: 31 - Stages: Post-IPO Equity, Series B, Series C - Focus: Biotechnology, Health Care, Pharmaceutical The firm is a 25-year-old global investment firm focused on healthcare with approximately $5.8 billion in AUM, which we have invested in over 290 public and private companies worldwide. Headquartered in Palo Alto, California, with offices in Asia. Our team consists of 50 multi-disciplinary professionals, including, physicians, scientists,entrepreneurs, operating executives, and industry experts. The firm operates as a multi-fund investment platform, covering growth equity, private equity including buyout, venture capital, and public equity. Vivo invests broadly in healthcare across all fund strategies, including biotechnology, pharmaceuticals, medical devices, and healthcare services, with a focus on the largest healthcare markets. ## Eli Lilly - Type: VC Fund - Location: Indianapolis, Indiana, United States - Relevant deals: 30 - Stages: Series A, Series B - Focus: Biotechnology, Health Care, Medical Lilly is a medicine company that puts health above all. Learn about our medicines, view condition support, find care, and much more.