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Top 10 Medical Device Startup Investors in South Africa in September 2025

Last updated: Sep 2025 A list of 10 angel investors and VC (Venture Capital) funds that invest in Medical device startups based in South africa. We rank investors based on the number of investments they made in Medical device companies from South africa. We update this investor list every month.

Top 10 Medical Device Startup Investors in South Africa in September 2025

Investor	Medical Device South Africa investments
54 Collective	2
HAVAÍC	2
Futuregrowth Asset Management	2
Bose Ventures	2
Bill & Melinda Gates Foundation	1
The ASISA ESD Fund	1
SAB Foundation	1
Verge HealthTech Fund	1
Technology Innovation Agency	1
Sphere Holdings	1

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Investor list

Building and scaling African tech startups with catalytic capital, value-add support and our global network.

Investment focus

Health Care, Information Technology, FinTech
Seed, Pre-Seed, Funding Round
Kenya, Nigeria, South Africa

Portfolio highlights

Billboxx — Empowering SMEs to pay and get paid on time, every time.
Yeah — Yeah is a financial technology company that offers payment processing services while building a credit profile for the banked and unbanked.
Konnect — Konnect provides a cross borders payment solution intended to simplify complex financial flows allowing companies of any scale and size to send and receive payments in a practical, secure, and low-cost way.

HAVAÍC is an investment and advisory firm that specialises in early-stage, high-growth African businesses with proven concepts and global prospects, offering investment opportunities to sophisticated investors and international venture capital companies with an interest in Africa. As a complementary offering, HAVAÍC provides corporate advisory andcapital raising services to emerging, internationally scalable businesses.

Investment focus

Software, Health Care, FinTech
Seed, Funding Round, Series A
South Africa, United States, Kenya

Portfolio highlights

NjiaPay — Payments-as-a-Service platform that will streamline your operations and elevate your online payments across the African continent.
Talk360 — Talk360 is an easy-to-use calling app that helps people make affordable international calls to any mobile and landline number. They believe that reliable communication and digital services must be affordable and accessible to everyone, regardless of someone's background. Especially people in emerging countries in Africa, who often need theseservices the most, do not always have the necessary banking possibilities. To bridge this distance, Talk360 will launch the world's first single checkout platform for Africa. This platform will combine all locally available payment methods and currencies across Africa, together with over 1.25 million cash points of sales, and will eventually be available to other companies as well. This means that 500 million Africans will be able to purchase digital services they never had access to before.
Right Now Response — The future of repairs starts soon. Counting down to smarter tracking in 2025! There are perks to working 24/7, 365 days a year... Like launching the future of repairs ahead of schedule!

Futuregrowth manages the full range of fixed interest and developmental impact funds on behalf of our clients. We are committed to managing and investing our clients' funds in a responsible manner.

Investment focus

Software, Logistics, Medical Device
Seed, Series B, Funding Round
South Africa, France, United States

Portfolio highlights

Tripplo — Tripplo is a platform to automate and optimise operations for transporters, cargo owners and cargo brokers.
Pineapple — In short, Pineapple see the traditional insurance model, user journey and products as lacking and set out to remedy these by doing the following: 1) Changing the business model to align incentives, show people how premiums are used and award members leftover premium back 2) Making insuring as easy as snapping a picture where AI does the rest andcover is issued in under 60 seconds 3) Allowing per-item insurance and new product innovation to address cover not currently offered or accessible to manyPineapple launched in South Africa in 2018 with their "My Stuff" per-item insurance and have since launched their auto offering "My Ride". They have also partnered with Travelers in the US and have white-labeled their platform in the US.
Sourcefin — Explore Sourcefin's purchase order funding and invoice discounting solutions. Achieve financial stability with Sourcefin's expert services.

Bose Ventures is looking for startups that are pushing the envelope of AR to help build some of these new experiences. They are investing in startups that are developing apps, services, and technology that leverage and extend the Bose AR platform. If you are one of these innovative startups

Investment focus

Software, Artificial Intelligence, Music
Funding Round, Series B, Series A
United States, India, Denmark

Portfolio highlights

Vesper — Vesper is an electrical and electronic manufacturing company that specializes in microphones, piezoelectric, and audio. The company is driven by a mission is to deliver voice-powered products to every market, around the world. Vesper was founded in 2009 and headquartered in Boston, Massachusetts.
Medrhythms — Pioneering Next-Generation Digital Therapeutics to Improve Walking  
Noise — Buy latest Noise smart watches, wireless earbuds, BT neckband earphones, wireless headphones, speakers and smart watch accessories online at best prices in India.

We are a nonprofit fighting poverty, disease, and inequity around the world

Investment focus

Biotechnology, Health Care, Medical
Grant, Series A, Series B
United States, United Kingdom, India

Portfolio highlights

Synvect — Synvect is a CRISPR-based mosquito control solution that leverages the power of biology to eradicate disease and nuisance. Its solutions are eco-friendly, cost-efficient, and effective.
SeamlessHR — Africa's Leading HR & Payroll Software - Empowering African Businesses for Productivity and Profitability Through Technology.
Leinco Technologies — Leinco Technologies focuses on monoclonal antibodies and protein specialists for diagnostics, therapeutics, flow cytometry, and other research areas. Their innovative products and services augment the early discovery process in life science research, diagnostics, and groundbreaking development of protein therapeutics.

An Invetsment Fund.

Investment focus

FinTech, Internet, InsurTech
Seed, Series B, Series A
South Africa

Portfolio highlights

I-G3N — I-G3N is a South African developer of lithium-ion batteries. The company’s core market is on stationary storage in conjunction with Solar PV and focuses on superior products and on the incorporation of the latest technologies to battery functionality. One of the key focus areas is on exporting to the SADC region and the rest of Africa, asextraordinary opportunities exist on the rest of the continent, especially in the development of mini and micro-grids to impact development.
Pineapple — In short, Pineapple see the traditional insurance model, user journey and products as lacking and set out to remedy these by doing the following: 1) Changing the business model to align incentives, show people how premiums are used and award members leftover premium back 2) Making insuring as easy as snapping a picture where AI does the rest andcover is issued in under 60 seconds 3) Allowing per-item insurance and new product innovation to address cover not currently offered or accessible to manyPineapple launched in South Africa in 2018 with their "My Stuff" per-item insurance and have since launched their auto offering "My Ride". They have also partnered with Travelers in the US and have white-labeled their platform in the US.
Aviro Health — We believe that empowering and supporting people to manage their own health benefits everybody.We built the Aviro Pocket Clinic to support self-care and provide access to services. We give people what they need to perform important health checks like regular HIV self-testing and connect them to experts and services who can offer hands-on and supported care when needed.

The SAB Foundation invests in entrepreneurs and social innovation. Its priority focus in on businesses and innovations that benefit women and youth, people in rural areas and people living with a disability.

Investment focus

Health Care, Manufacturing, Medical Device
Funding Round
South Africa

Portfolio highlights

LIQID Medical — Glaucoma Implants in South Africa. Liqid Medical is a medical device company focusing on addressing the need for effective, long-rerm solutions for glaucoma treatment.

We make early investments in global healthcare technology companies that address prevention, disease management and health system efficiency that are relevant to emerging AsiaWe believe that innovation can happen anywhere, from the streets of Dhaka to the labs of Oxford, however without the right support network, these solutions might notscale, or find the best world-changing application. This is where we can help.

Investment focus

Health Care, Medical Device, Medical
Seed, Pre-Seed, Series A
Estonia, Singapore, United Kingdom

Portfolio highlights

Prosoma — Prosoma was born out a need to provide more comprehensive care for cancer patients. We have found a fundamental lack of access to psychological care for patients who not only have to face a life-altering disease and treatment, but also crucially have a different set of needs than other psychological patients. Barriers to accessing psychologicalcare often include low numbers of therapists and clinicians in the area, financial or geographical limitations, and the general wellbeing of patients preventing them from attending meetings. All of these issues can be solved by modern technology.By using VR as part of, or when necessary, an alternative to traditional psychological treatment, we can reach patients that would otherwise be left without any support. They can use our tool at home or in the clinics whilst undergoing pharmacological treatment and chemotherapy.We hope to provide patients with a tool that will help them manage stress, cope with the burden of cancer, and eventually improve their quality of life.
Lifeyear — Digital-first heart care. At scale.
CareLoop Health — CareLoop, an innovation emerging from the University of Manchester, furnishes patients with digital support resources while simultaneously providing healthcare professionals with the means to monitor and track patient symptoms.

TIA is an initiative of the Department of Science & Technology (DST) in South Africa, to enable and support technological innovation.

Investment focus

Information Technology, Renewable Energy, Health Care
Grant, Seed, Pre-Seed
South Africa

Portfolio highlights

Jobox — Jobox is a student recruitment platform, built to connect employers, students and graduate career offices. Our focus is to improve graduate employability by ensuring all students have the skills they need to enter, stay in, and progress in the world of work.Jobox’s ecosystem provides employers with access to the best diverse & youthfultalent, students with more employment opportunities and universities with data-driven insights aimed at driving graduate employability forward.
Aviro Health — We believe that empowering and supporting people to manage their own health benefits everybody.We built the Aviro Pocket Clinic to support self-care and provide access to services. We give people what they need to perform important health checks like regular HIV self-testing and connect them to experts and services who can offer hands-on and supported care when needed.
Ownedby Technologies — Ownedby is an interactive asset management solution for business and household assets, focused on appliances and devices, giving these unique identity that is traceable online, yet linked to and controlled by owners.

Founded in 2003, Sphere is a high performing investment holding company driven to create value for funders, shareholders and business partners. With a solid track record shaped over a decade, They actively seek out investment partnerships with high quality privately owned businesses across a range of strategic sectors.Their success is drivenby an experienced team, Their own capital, a disciplined investment process, and broad business networks. Passionate about partnerships, They commit for the long term and actively work with Their portfolio companies to build great businesses.Majority black controlled and managed and boasting 71% black ownership, including 31% women ownership, Sphere has the necessary credentials to advance the broad based Black Economic Empowerment goals of South African businesses. As the focus turns to the rest of the continent, They actively support Their investments in their pan-African ambitions.Their strong belief in the principles of broad based empowerment means that approximately 15% of the shares in Sphere are held by charitable organisations. Over the years, more than five million worthy beneficiaries in nine provinces across South Africa have benefited from Their track record of delivery.

Investment focus

Software, Web Apps, Health Care
Series A
South Africa

Portfolio highlights

hearX Group — hearX is an award-winning start-up with the mission of providing affordable access to hearing healthcare using smart digital solutions. With a strong research and engineering background, we aim to democratize and decentralize hearing care, obliterating the traditional audiology model and market, which was never built to scale, instead providinghearing care to millions by leveraging our smart tech, big data and artificial intelligence expertise.The hearX Group four categories of solutions: Lead Generation and Remote Care solutions, Clinical solutions, Preventative Solutions as well as Direct to Consumer intervention solutions.We have had more than 1 000 000 tests and screenings done using our products across 39 countries. Our innovative solutions are as accurate, but faster, cheaper and easier to use than traditional methods. We pride ourselves in offering a fully managed service, providing an entirely new way to overcome traditional barriers to the detection and diagnosis of disabling hearing loss.

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