Top 10 Medical Device Startup Investors in South Africa in May 2026

Portfolio highlights

• Vesper — Vesper is an electrical and electronic manufacturing company that specializes in microphones, piezoelectric, and audio. The company is driven by a mission is to deliver voice-powered products to every market, around the world. Vesper was founded in 2009 and headquartered in Boston, Massachusetts.
• Medrhythms — Pioneering Next-Generation Digital Therapeutics to Improve Walking  
• Noise — Buy latest Noise smart watches, wireless earbuds, BT neckband earphones, wireless headphones, speakers and smart watch accessories online at best prices in India.

Portfolio highlights

• Billboxx — Manage payables, receivables, financing and banking in one platform.
• mTek — mTek is a digital online insurance platform that provides an entirely paperless ecosystem for the insurance industry.
• REasy — Top up locally, pay suppliers globally, and manage international shipments with REasy. Fast, secure, and designed for African businesses expanding worldwide.

Portfolio highlights

• NjiaPay — Payments-as-a-Service platform that will streamline your operations and elevate your online payments across the African continent.
• Talk360 — Talk360 is an easy-to-use calling app that helps people make affordable international calls to any mobile and landline number. They believe that reliable communication and digital services must be affordable and accessible to everyone, regardless of someone's background. Especially people in emerging countries in Africa, who often need theseservices the most, do not always have the necessary banking possibilities. To bridge this distance, Talk360 will launch the world's first single checkout platform for Africa. This platform will combine all locally available payment methods and currencies across Africa, together with over 1.25 million cash points of sales, and will eventually be available to other companies as well. This means that 500 million Africans will be able to purchase digital services they never had access to before.
• Right Now Response — The future of repairs starts soon. Counting down to smarter tracking in 2025! There are perks to working 24/7, 365 days a year... Like launching the future of repairs ahead of schedule!

Portfolio highlights

• Tripplo — Tripplo is a platform to automate and optimise operations for transporters, cargo owners and cargo brokers.
• Pineapple — In short, Pineapple see the traditional insurance model, user journey and products as lacking and set out to remedy these by doing the following: 1) Changing the business model to align incentives, show people how premiums are used and award members leftover premium back 2) Making insuring as easy as snapping a picture where AI does the rest andcover is issued in under 60 seconds 3) Allowing per-item insurance and new product innovation to address cover not currently offered or accessible to manyPineapple launched in South Africa in 2018 with their "My Stuff" per-item insurance and have since launched their auto offering "My Ride". They have also partnered with Travelers in the US and have white-labeled their platform in the US.
• Sourcefin — Quick PO funding & invoice discounting with expert support. Get funded in 48 hours. No hidden fees. We've helped 1000s of SA SMMEs. Apply now.

Portfolio highlights

• Ensoma — Ensoma is expanding the reach of the curative power of genomic medicine by pioneering a next-generation in vivo approach using its Engenious™ vectors. Ensoma’s vectors are designed to deliver a diverse range of gene modification technologies without the need for stem cell collection or prior myeloablative conditioning (e.g., chemotherapy). As aresult, Ensoma’s therapies can be delivered as a single injection in a diverse range of settings, including outpatient and settings where access to sophisticated healthcare systems may be limited.
• Aspen Pharmacare — Aspen is a global specialty and branded multinational pharmaceutical company with a presence in both emerging and developed markets
• NILO Therapeutics — A neuronal circuit regulates the immune system. We're targeting it to treat autoimmune and inflammatory diseases.

Portfolio highlights

• I-G3N — I-G3N is a South African developer of lithium-ion batteries. The company’s core market is on stationary storage in conjunction with Solar PV and focuses on superior products and on the incorporation of the latest technologies to battery functionality. One of the key focus areas is on exporting to the SADC region and the rest of Africa, asextraordinary opportunities exist on the rest of the continent, especially in the development of mini and micro-grids to impact development.
• Pineapple — In short, Pineapple see the traditional insurance model, user journey and products as lacking and set out to remedy these by doing the following: 1) Changing the business model to align incentives, show people how premiums are used and award members leftover premium back 2) Making insuring as easy as snapping a picture where AI does the rest andcover is issued in under 60 seconds 3) Allowing per-item insurance and new product innovation to address cover not currently offered or accessible to manyPineapple launched in South Africa in 2018 with their "My Stuff" per-item insurance and have since launched their auto offering "My Ride". They have also partnered with Travelers in the US and have white-labeled their platform in the US.
• Aviro Health — We believe that empowering and supporting people to manage their own health benefits everybody.We built the Aviro Pocket Clinic to support self-care and provide access to services. We give people what they need to perform important health checks like regular HIV self-testing and connect them to experts and services who can offer hands-on and supported care when needed.

Portfolio highlights

• LIQID Medical — Glaucoma Implants in South Africa. Liqid Medical is a medical device company focusing on addressing the need for effective, long-rerm solutions for glaucoma treatment.

Portfolio highlights

• Susu — Susu is a dynamic and innovative company that offers a wide range of health services for families in the African diaspora. Susu provides a complete offer on Preventive care, Medical treatments, Management of chronic diseases, and Authentic drugs.
• Kasha — Health products and household goods you want, delivered to where you are.
• Zuri Health — .ts-banner-image-1:hover .overlay{background-color:#ffffff} .ts-banner-image-2:hover .overlay{background-color:#ffffff} Popular categories Pharmacy Doctor at home Covid Labs & Diagonstics Wellness Telemed Show all Our Services PharmacyBuy both OTC and prescription medication and have it delivered to your doorstepLabs & DiagnosticsBook labs and Diagnostic tests and get your samples collected from the comfort of your home, hotel

Portfolio highlights

• Affinity — Affinity is a financial solutions company that provides financial inclusion, advisory, and literacy services.
• ToumAI Analytics — ToumAI Analytics is a software development company providing voice analytics, real-time analytics, and reporting services.
• PBR Life Sciences — A cloud-based real-world, non-observational pharmacy sell-out data

Portfolio highlights

• Prosoma — Prosoma was born out a need to provide more comprehensive care for cancer patients. We have found a fundamental lack of access to psychological care for patients who not only have to face a life-altering disease and treatment, but also crucially have a different set of needs than other psychological patients. Barriers to accessing psychologicalcare often include low numbers of therapists and clinicians in the area, financial or geographical limitations, and the general wellbeing of patients preventing them from attending meetings. All of these issues can be solved by modern technology.By using VR as part of, or when necessary, an alternative to traditional psychological treatment, we can reach patients that would otherwise be left without any support. They can use our tool at home or in the clinics whilst undergoing pharmacological treatment and chemotherapy.We hope to provide patients with a tool that will help them manage stress, cope with the burden of cancer, and eventually improve their quality of life.
• Lifeyear — Digital-first heart care. At scale.
• CareLoop Health — CareLoop, an innovation emerging from the University of Manchester, furnishes patients with digital support resources while simultaneously providing healthcare professionals with the means to monitor and track patient symptoms.