Top 15 Medical Device Startup Investors in South Africa (August 2026)

Portfolio highlights

• CubeSpace — Industry-leading modular attitude determination and control (ADCS) products and solutions. Laser-focused on our customers' success. Your global ADCS partner.
• SweepSouth — Book a home cleaning online from your mobile, tablet or computer. SweepSouth connects you with a cleaner in minutes. Cleaners are experienced, reliable, efficient and insured.
• Happy Pay — Happy Pay is a credit scoring system developing company. The company integrates an autonomous artificial intelligence technology system with the merchant's platform to increase their average basket size and customer conversion metrics, providing users with buy now, and pay later services.

Portfolio highlights

• Vesper — Vesper is an electrical and electronic manufacturing company that specializes in microphones, piezoelectric, and audio. The company is driven by a mission is to deliver voice-powered products to every market, around the world. Vesper was founded in 2009 and headquartered in Boston, Massachusetts.
• Medrhythms — Pioneering Next-Generation Digital Therapeutics to Improve Walking  
• Noise — Buy latest Noise smart watches, wireless earbuds, BT neckband earphones, wireless headphones, speakers and smart watch accessories online at best prices in India.

Portfolio highlights

• LipaLater — LipaLater is a lending marketplace that provides postpaid payments at e-commerce stores. They are making technology affordable for you. Get the electronic of your choice today and pay for it in comfortable monthly installments.
• REasy — Top up locally, pay suppliers globally, and manage international shipments with REasy. Fast, secure, and designed for African businesses expanding worldwide.
• Konnect — Konnect provides a cross borders payment solution intended to simplify complex financial flows allowing companies of any scale and size to send and receive payments in a practical, secure, and low-cost way.

Portfolio highlights

• Immobazyme — Immobazyme provides pioneering the biotechnology industry. Using innovative technologies, along with an environmentally responsible outlook.the company aims to develop an analytical laboratory platform as well as serve the industrial sector through the production of high-value products by organic synthesis and environmental remediationtechnologies.
• Happy Pay — Happy Pay is a credit scoring system developing company. The company integrates an autonomous artificial intelligence technology system with the merchant's platform to increase their average basket size and customer conversion metrics, providing users with buy now, and pay later services.
• MariHealth Solutions (RF) (PTY) LTD — Proteomics-powered analytics for aquaculture. We quantify 3,000+ proteins per sample to deliver deep biological insights for fish health, nutrition, and farming.

Portfolio highlights

• MPost — MPost means Mobile Post office.It enables any mobile phone user to have his or her phone act like a mobile post office. It allows you to make your mobile number be a formal postal address. With it, you get access to Postal Services through your mobile phone.
• AURA — A South African cloud-based security and safety startup .
• Digital Cabinet — Digital Cabinet makes your business paperless. Security is the topmost priority for the Digital Cabinet, so save time and money with the Digital Cabinet.

Portfolio highlights

• hearX Group — hearX is an award-winning start-up with the mission of providing affordable access to hearing healthcare using smart digital solutions. With a strong research and engineering background, we aim to democratize and decentralize hearing care, obliterating the traditional audiology model and market, which was never built to scale, instead providinghearing care to millions by leveraging our smart tech, big data and artificial intelligence expertise.The hearX Group four categories of solutions: Lead Generation and Remote Care solutions, Clinical solutions, Preventative Solutions as well as Direct to Consumer intervention solutions.We have had more than 1 000 000 tests and screenings done using our products across 39 countries. Our innovative solutions are as accurate, but faster, cheaper and easier to use than traditional methods. We pride ourselves in offering a fully managed service, providing an entirely new way to overcome traditional barriers to the detection and diagnosis of disabling hearing loss.

Portfolio highlights

• Aviro Health — We believe that empowering and supporting people to manage their own health benefits everybody.We built the Aviro Pocket Clinic to support self-care and provide access to services. We give people what they need to perform important health checks like regular HIV self-testing and connect them to experts and services who can offer hands-on and supported care when needed.
• Sensor Networks — Sensor Networks helps insurance companies improve risk mitigation, enhance loss management and better engage with customers through smart sensors. We've created Sensor Desk, an Internet of Things (IoT) platform that controls and manages a range of internally developed and third-party-connected sensors. Our focus is to predict and prevent lossor damage insurance claims, improve operational efficiency and reduce costs for end users.
• Creslow Energy Solutions — Creslow Energy Solutions is a manufacturer of sustainable energy storage technologies.

Portfolio highlights

• Syked — Emotional support has never been this convenient; with sessions in the comfort of your own home it's like having your therapist in the palm of your hand.
• Respo — Respo is a provider of comprehensive emergency response solutions, leveraging innovative technology and strategic partnerships to deliver timely and response.
• The Marking App — The Marking App provides a data-free application that automatically marks handwritten school assessments while also automating school administration.

Portfolio highlights

• Ctrack — Ctrack is the vehicle tracking provider with more than 24 years' experience of developing effective fleet solutions. Ctrack is a part of DigiCore Holdings, a global company listed on the Johannesburg Stock Exchange, whose advanced Ctrack technology is fitted to almost 430,000 vehicles operating in 32 countries across 5 continents.
• Peach Payments — Get Peach as your Payment Gateway and Grow your ecommerce. Process online payments with Visa, Mastercard, Debit Orders, EFT payments, and subscriptions. Plugins for Wix, Shopify, WooCommerce.
• Barracuda Holdings — Barracuda Holdings (Pty) Ltd. is an owner-driven company established in 2010 by the founding partners, each of whom has over 20 years of experience. Barracuda Holdings provides manufacturing expertise across multiple sectors, including Automotive accessories, diagnostic tools, and fleet management.

Portfolio highlights

• Pineapple — In short, Pineapple see the traditional insurance model, user journey and products as lacking and set out to remedy these by doing the following: 1) Changing the business model to align incentives, show people how premiums are used and award members leftover premium back 2) Making insuring as easy as snapping a picture where AI does the rest andcover is issued in under 60 seconds 3) Allowing per-item insurance and new product innovation to address cover not currently offered or accessible to manyPineapple launched in South Africa in 2018 with their "My Stuff" per-item insurance and have since launched their auto offering "My Ride". They have also partnered with Travelers in the US and have white-labeled their platform in the US.
• Aviro Health — We believe that empowering and supporting people to manage their own health benefits everybody.We built the Aviro Pocket Clinic to support self-care and provide access to services. We give people what they need to perform important health checks like regular HIV self-testing and connect them to experts and services who can offer hands-on and supported care when needed.
• Ngobese And Associates — Ngobese And Associates is a Financial Services providing firm offering brokeraging, advisory and intermediary services.

Portfolio highlights

• Ann-Connect — Ann-Connect is an EdTech SaaS for learning, teaching, exams and assessments rolled into an all-in-one education platform.Founded in 2021 by Bonginkosi Mabaso, Nexa was born from a real problem: students missing exams and learning opportunities because of unreliable internet. Our mission is simple: make online education accessible to everystudent, regardless of connectivity or background. Today, Nexa is trusted by universities, training institutions, and professional bodies across South Africa, with partnerships that give access to more than 450,000 learners. One workspace. All your education tools: - Nexa ExamCore: Offline exam tool where students can access, write, and submit online exams even without internet. - Nexa Invigilator: Invigilation tool designed to monitor for online exams. - Nexa Invigilator Venue-based – Proctoring for physical/venue-based exams for schools, corporates & teams. - Nexa Room – Low-bandwidth video conferencing just like MS Teams but designed for teaching and learning, with AI-driven student engagement tracking. - Integrations – Seamless connection with Learning Management Systems (LMS), plagiarism checkers, and other education tools — all in one place. Recognised with awards from TIA, ABSA, and the Royal Academy of Engineering (UK), Nexa is shaping the future of global education by making it inclusive, resilient, and accessible everywhere. Ready to experience THE platform for inclusive learning? Visit ann-connect.com and join us in building education without limits.
• Aviro Health — We believe that empowering and supporting people to manage their own health benefits everybody.We built the Aviro Pocket Clinic to support self-care and provide access to services. We give people what they need to perform important health checks like regular HIV self-testing and connect them to experts and services who can offer hands-on and supported care when needed.
• All Weather Roads Engineering — All Weather Roads Engineering is a building material manufacturing firm also offering supply of construction material.

Portfolio highlights

• Zoundream — The Future of Infant Care
• Understanding Zoe — One calm home that remembers for you and grows with your family. Built in Australia for families raising neurodivergent children. Try free for 7 days.
• Neuraworx Medical Technology — Neuraworx Medical Technology is a neurotechnology company developing first-in-class bioelectronic solutions for brain health.

Portfolio highlights

• Zazu — Zazu is a neobank for African SMEs, offering seamless banking tools, cash flow automation, and real-time insights. Zazu simplifies finance management in one all-in-one solution.
• Fincart — Fincart is a leading shipping platform in Egypt, connecting your business with top courier services, automating operations, and helping you scale your eCommerce logistics.
• Udu Technologies — Udu Technologies is an AI infrastructure company that offers GPU systems, AI platform integration, and technical support services.

Portfolio highlights

• Susu — Susu is a dynamic and innovative company that offers a wide range of health services for families in the African diaspora. Susu provides a complete offer on Preventive care, Medical treatments, Management of chronic diseases, and Authentic drugs.
• Kasha — Health products and household goods you want, delivered to where you are.
• Fincart — Fincart is a leading shipping platform in Egypt, connecting your business with top courier services, automating operations, and helping you scale your eCommerce logistics.

Portfolio highlights

• Immunocore — Immunocore is focused on the discovery and development of novel T cell receptor-based drugs to treat diseases with a high unmet need, including cancer and viral disease. The company’s expertise in engineering T Cell Receptors (TCRs) and linking them to an antibody fragment (scFv) known as anti-CD3, has led to its first product candidate, IMCgp100,entering clinical trials in patients with metastatic melanoma. The proprietary T Cell Receptor technology platform is well validated and can easily be manufactured for clinical and commercial supply in microbial systems. Immunocore is a biotechnology company that specializes in the development of TCR bispecific immunotherapies.
• SeamlessHR — Africa's Leading HR & Payroll Software - Empowering African Businesses for Productivity and Profitability Through Technology.
• BioNTech — BioNTech is a next-generation immunotherapy company pioneering novel therapies for cancer and other serious diseases. It contains several classes of drugs, including mRNA-based drugs to encode antigens, neoantigens, cytokines, and antibodies; cell therapies; bispecific antibodies; and antibody-drug conjugates.