Top 15 Medical Device Startup Investors in South Africa (November 2026)

Portfolio highlights

• Jem — We give employers the ability to send company-wide communications, deliver payslips, manage leave & give employees access to their earnings, via WhatsApp.
• Immobazyme — Immobazyme provides pioneering the biotechnology industry. Using innovative technologies, along with an environmentally responsible outlook.the company aims to develop an analytical laboratory platform as well as serve the industrial sector through the production of high-value products by organic synthesis and environmental remediationtechnologies.
• Happy Pay — Happy Pay is a credit scoring system developing company. The company integrates an autonomous artificial intelligence technology system with the merchant's platform to increase their average basket size and customer conversion metrics, providing users with buy now, and pay later services.

Portfolio highlights

• CubeSpace — Industry-leading modular attitude determination and control (ADCS) products and solutions. Laser-focused on our customers' success. Your global ADCS partner.
• Jem — We give employers the ability to send company-wide communications, deliver payslips, manage leave & give employees access to their earnings, via WhatsApp.
• Happy Pay — Happy Pay is a credit scoring system developing company. The company integrates an autonomous artificial intelligence technology system with the merchant's platform to increase their average basket size and customer conversion metrics, providing users with buy now, and pay later services.

Portfolio highlights

• Vesper — Vesper is an electrical and electronic manufacturing company that specializes in microphones, piezoelectric, and audio. The company is driven by a mission is to deliver voice-powered products to every market, around the world. Vesper was founded in 2009 and headquartered in Boston, Massachusetts.
• Medrhythms — Pioneering Next-Generation Digital Therapeutics to Improve Walking  
• Noise — Buy latest Noise smart watches, wireless earbuds, BT neckband earphones, wireless headphones, speakers and smart watch accessories online at best prices in India.

Portfolio highlights

• Yeah — Yeah is a financial technology company that offers payment processing services while building a credit profile for the banked and unbanked.
• REasy — Top up locally, pay suppliers globally, and manage international shipments with REasy. Fast, secure, and designed for African businesses expanding worldwide.
• Konnect — Konnect provides a cross borders payment solution intended to simplify complex financial flows allowing companies of any scale and size to send and receive payments in a practical, secure, and low-cost way.

Portfolio highlights

• NjiaPay — Payments-as-a-Service platform that will streamline your operations and elevate your online payments across the African continent.
• SwiftVee — SwiftVEE is a livestock trading mobile app. They support live webcast livestock auctions and silent auctions. Their platform facilitates the discovery and viewing of livestock auctions.They provide webcast advertising, online auctions, and online livestock insurance services and data products for financial institutions.
• Tanda — As a Tanda Agent, you can sell Kenya's favorite digital products, and grow your duka while you're at it

Portfolio highlights

• Ann-Connect — Ann-Connect is an EdTech SaaS for learning, teaching, exams and assessments rolled into an all-in-one education platform.Founded in 2021 by Bonginkosi Mabaso, Nexa was born from a real problem: students missing exams and learning opportunities because of unreliable internet. Our mission is simple: make online education accessible to everystudent, regardless of connectivity or background. Today, Nexa is trusted by universities, training institutions, and professional bodies across South Africa, with partnerships that give access to more than 450,000 learners. One workspace. All your education tools: - Nexa ExamCore: Offline exam tool where students can access, write, and submit online exams even without internet. - Nexa Invigilator: Invigilation tool designed to monitor for online exams. - Nexa Invigilator Venue-based – Proctoring for physical/venue-based exams for schools, corporates & teams. - Nexa Room – Low-bandwidth video conferencing just like MS Teams but designed for teaching and learning, with AI-driven student engagement tracking. - Integrations – Seamless connection with Learning Management Systems (LMS), plagiarism checkers, and other education tools — all in one place. Recognised with awards from TIA, ABSA, and the Royal Academy of Engineering (UK), Nexa is shaping the future of global education by making it inclusive, resilient, and accessible everywhere. Ready to experience THE platform for inclusive learning? Visit ann-connect.com and join us in building education without limits.
• Aviro Health — We believe that empowering and supporting people to manage their own health benefits everybody.We built the Aviro Pocket Clinic to support self-care and provide access to services. We give people what they need to perform important health checks like regular HIV self-testing and connect them to experts and services who can offer hands-on and supported care when needed.
• All Weather Roads Engineering — All Weather Roads Engineering is a building material manufacturing firm also offering supply of construction material.

Portfolio highlights

• Susu — Susu is a dynamic and innovative company that offers a wide range of health services for families in the African diaspora. Susu provides a complete offer on Preventive care, Medical treatments, Management of chronic diseases, and Authentic drugs.
• Kasha — Health products and household goods you want, delivered to where you are.
• Fincart — Fincart is a leading shipping platform in Egypt, connecting your business with top courier services, automating operations, and helping you scale your eCommerce logistics.

Portfolio highlights

• THINKMD — THINKMD develops next-generation clinical assessment and data analytics platforms that transform point-of-care medicine by putting medically validated clinical assessment capability into the hands of non-healthcare professionals. This technology allows for the decentralization of healthcare delivery into communities and homes by pairing clinicalknowledge and Bayesian/pattern recognition algorithms with simple to use mobile technology. Its goal is to reinvent the healthcare delivery paradigm, reduce costs, and improve outcomes by improving healthcare access and care-seeking behavior while building a public health knowledge database.
• Understanding Zoe — One calm home that remembers for you, for a whole life. Built in Australia for neurodivergent adults and families. Try free for 7 days.
• Neuraworx Medical Technology — Neuraworx Medical Technology is a neurotechnology company developing first-in-class bioelectronic solutions for brain health.

Portfolio highlights

• Ctrack — Ctrack is the vehicle tracking provider with more than 24 years' experience of developing effective fleet solutions. Ctrack is a part of DigiCore Holdings, a global company listed on the Johannesburg Stock Exchange, whose advanced Ctrack technology is fitted to almost 430,000 vehicles operating in 32 countries across 5 continents.
• Peach Payments — Get Peach as your Payment Gateway and Grow your ecommerce. Process online payments with Visa, Mastercard, Debit Orders, EFT payments, and subscriptions. Plugins for Wix, Shopify, WooCommerce.
• Barracuda Holdings — Barracuda Holdings (Pty) Ltd. is an owner-driven company established in 2010 by the founding partners, each of whom has over 20 years of experience. Barracuda Holdings provides manufacturing expertise across multiple sectors, including Automotive accessories, diagnostic tools, and fleet management.

Portfolio highlights

• Zazu — Manza is an all-in-one financial platform for African SMEs, helping businesses manage payments, automate cash flow, and access real-time financial insights from one simple dashboard.
• Fincart — Fincart is a leading shipping platform in Egypt, connecting your business with top courier services, automating operations, and helping you scale your eCommerce logistics.
• Udu Technologies — Explore GPU cloud and hardware through AGH Cloud, UduTech's flagship product, and AI advisory for teams in the United States, Africa, the Caribbean and beyond.

Portfolio highlights

• DaltonTx — Dalton brings your scientists, AI agents and every experimental result into one system that learns. Built in London for pharma, biotech and CRO discovery teams.
• SeamlessHR — Africa's Leading HR & Payroll Software - Empowering African Businesses for Productivity and Profitability Through Technology.
• Blue Lake Biotechnology — Blue Lake Biotechnology is a startup company that focuses on developing a human vaccine using a novel viral vector. Its goal is to develop PIV5-based vaccines for human disease with an initial focus on the respiratory syncytial virus, as well as obtain the FDA’s approval for a phase I trial.The company is located in Athens, Georgia, and wasfounded in 2019 by Biao He.

Portfolio highlights

• Pineapple — In short, Pineapple see the traditional insurance model, user journey and products as lacking and set out to remedy these by doing the following: 1) Changing the business model to align incentives, show people how premiums are used and award members leftover premium back 2) Making insuring as easy as snapping a picture where AI does the rest andcover is issued in under 60 seconds 3) Allowing per-item insurance and new product innovation to address cover not currently offered or accessible to manyPineapple launched in South Africa in 2018 with their "My Stuff" per-item insurance and have since launched their auto offering "My Ride". They have also partnered with Travelers in the US and have white-labeled their platform in the US.
• Aviro Health — We believe that empowering and supporting people to manage their own health benefits everybody.We built the Aviro Pocket Clinic to support self-care and provide access to services. We give people what they need to perform important health checks like regular HIV self-testing and connect them to experts and services who can offer hands-on and supported care when needed.
• Ngobese And Associates — Ngobese And Associates is a Financial Services providing firm offering brokeraging, advisory and intermediary services.

Portfolio highlights

• Aviro Health — We believe that empowering and supporting people to manage their own health benefits everybody.We built the Aviro Pocket Clinic to support self-care and provide access to services. We give people what they need to perform important health checks like regular HIV self-testing and connect them to experts and services who can offer hands-on and supported care when needed.
• Sensor Networks — Sensor Networks helps insurance companies improve risk mitigation, enhance loss management and better engage with customers through smart sensors. We've created Sensor Desk, an Internet of Things (IoT) platform that controls and manages a range of internally developed and third-party-connected sensors. Our focus is to predict and prevent lossor damage insurance claims, improve operational efficiency and reduce costs for end users.
• Creslow Energy Solutions — Creslow Energy Solutions is a manufacturer of sustainable energy storage technologies.

Portfolio highlights

• wamly — Wamly is the recruitment software, It has given us time back to focus on transformational work.
• Cue — Cue is one customer service platform for live chat, chatbots and broadcasts across WhatsApp, Messenger, web chat, email and many other digital channels.
• Optique Optometrists — Optique Optometrists provides comprehensive eye care services, including eye tests, prescription glasses, and contact lenses. The company offers affordable eye care solutions and has multiple branches across South Africa. Customers can book appointments online and access a wide range of eyewear options. Optique Optometrists focuses on deliveringquality vision care and ensuring customer satisfaction through professional services and convenient booking options.

Portfolio highlights

• Respo — Respo technology as a catalyst for positive change highlights the potential for innovation to improve lives and foster community. Respo focuses on ethical development and the importance of user-centered design, ensuring that advancements benefit society.
• The Marking App — The Marking App provides a data-free application that automatically marks handwritten school assessments while also automating school administration.
• Word Of Mouth — Word of Mouth is a South African social enterprise (NPC), with a digital marketplace for informal economy workers to connect and trade with local customer from their community.