Top 50 Software Startup Investors in Panama (June 2026)

Portfolio highlights

• Aark — Trade crypto perpetuals with up to 1000x leverage, zero gas fees, and an industry-low 0.01% trading fee. Earn payback on losses with VIP rewards. RWA & altcoin perps on Arbitrum. Backed by OKX Ventures.
• Ta-da — We collect, annotate, and label audio, image, video, and text data to power your AI training. From voice and facial recognition to biometrics and object detection, we build tailored datasets for your needs.
• Itheum — As we enter the web3 and metaverse era; Itheum unlocks data silos and generates new value for your data.

Portfolio highlights

• The Arena — A next gen SocialFi app redefining how creators connect, engage, and monetize their content.
• Joystream — Joystream is a block chain-based, decentralized video platform.
• Sigma Computing — Sigma is the only BI analytics tool purpose-built for your cloud data warehouse. Uniquely scalable, with an experience you already know: the spreadsheet.

Portfolio highlights

• Cogni — Cogni is a new digital banking platform that brings you curated brands and experiences while helping manage your spend.
• GAMES.GG — Discover 1,500+ games with honest reviews, expert guides, and daily gaming news across PC, console, and mobile. Find your next favorite game on Steam, Epic Games, PlayStation, Xbox, and Nintendo.
• Snackclub — Learn more about play to earn games

Portfolio highlights

• Treyee — We engineer revolutionary AI products and solutions that redefine enterprise capabilities. Our cutting-edge technology transforms raw data into strategic intelligence, empowering organisations to dominate markets, automate at scale, and unlock unprecedented opportunities. We're building the future where ambitious enterprises lead throughintelligent innovation.

Portfolio highlights

• EBR Systems — EBR aims for outstanding treatment of cardiac rhythm diseases with an innovative leadless therapy.
• Cardiac Dimensions — Cardiac Dimensions, Inc. is a medical device company developing novel interventional tools for the treatment of heart failure and the related condition of mitral valve regurgitation. Our product, the Carillon® Mitral Contour System®, is a groundbreaking, non-surgical device developed to treat functional mitral valve regurgitation. Our system uses acatheter based approach to reshape the mitral valve and reduce mitral regurgitation.
• Ignite Tournaments — Ready to take your mobile games to the next level? Join Ignite Tournaments and compete in real money esports tournaments. Download our app now and win big!

Portfolio highlights

• 0G — The First Decentralized AI Operating System
• DNABLOCK — We enable Web3 creator communities to design and mint NFT collections of truly custom photorealistic 3D avatars, environments and cinema-quality animated content with no code or animation knowledge.
• Ignite Tournaments — Ready to take your mobile games to the next level? Join Ignite Tournaments and compete in real money esports tournaments. Download our app now and win big!

Portfolio highlights

• Ignite Tournaments — Ready to take your mobile games to the next level? Join Ignite Tournaments and compete in real money esports tournaments. Download our app now and win big!

Portfolio highlights

• AEON — AEON is a crypto payment framework designed for AI-driven and real-world transactions. It supports omni-chain payments across ecosystems like EVM, SVM, and TON, enabling seamless cross-chain usage. Its solutions include AI-powered payments, Web3 online and mobile payments, QR/contactless acceptance, and swap pay, all designed to simplifyadoption for users and merchants.
• AlchemyNFT — AlchemyNFT is a non-fungible token (NFT) service.
• Unitas —

Portfolio highlights

• MSafe — MSafe offers the most secure, decentralized, scalable Web3 non-custodial, multi-signature solution built on Move, ideal for dApp developers to use for treasury management, token management, smart contract development, blockchain protocol admin control, live on Aptos
• Momentum — Momentum is a move central liquidity engine with multi-sig treasury management, token vesting, and liquidity provisioning.
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• GENCY AI — Gency AI is a Web3 platform for privacy-focused, verifiable digital ads using encrypted data and proof-based tracking.
• Voyage — Voyage AI is an AI infrastructure project building the first GEOFi network to make AI-generated content citable.
• Interstate — Interstate is an Ethereum pre-confirmation protocol. It aims to make Ethereum transactions near-instant and allow applications to self-order while maintaining full composability with L1.

Portfolio highlights

• myco — myco is a content streaming super dApp that smoothly integrates AVOD and SVOD capabilities into a decentralized ecosystem.
• Metametaverse — Discover the future of virtual worlds with our metaverse platform. Explore, create and monetize your own metaverse experiences in a seamless and secure manner. Join the cosmic system of metaverses today.
• Ignite Tournaments — Ready to take your mobile games to the next level? Join Ignite Tournaments and compete in real money esports tournaments. Download our app now and win big!

Portfolio highlights

• SnakeLite — Snake Lite is a classic arcade snake game with a competitive edge and offers offline and online play. It is designed for smooth controls and fast performance.
• Sophon — Sophon brings the benefits of blockchain to everyday entertainment without the complexity. Discover games, social experiences, and applications that put users first, not technology.
• Eizper Chain — Eizper Chain is a blockchain action online multiplayer role-playing game that celebrates adventure and arena battle.

Portfolio highlights

• Metatheory — Metatheory Inc. is an interactive technology and entertainment company building Web3 games, interactive content, social experiences, and other community-driven adventures. Metatheory’s mission is to inspire imagination by connecting people worldwide through immersive worlds built on cross-generational IP.
• Pagos Solutions — Get real-time payment data detecting issues, trends, and opportunities plus intelligent payment solutions for optimizing payment performance.
• Spaceport Technologies — Accelerating the growth of the next digital economy

Portfolio highlights

• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.
• Xion Finance — Xion Finance is the easiest way to start earning a passive income on your crypto. Earn interest, shop products or yield farm with a novel one click to DeFi protocol. Get Started Today!
• QANplatform [QAN blockchain platform] — QANplatform is the quantum-resistant Layer 1 hybrid blockchain where developers can code web3 solutions in any language on top of the QAN blockchain platform.

Portfolio highlights

• EclipseFi — EclipseFi is a Cosmos modular multi-chain token issuance platform that seeks to tackle Launchpad's cross-chain user experience and sustainability challenges with features like smart accounts and cross-chain design.
• Term Labs — Fixed rate lending for everyone
• Nexio — Nexio is a bitcoin scaling solution platform that helps to improve cryptocurrency's scalability by using parallelizing Bitcoin rollouts.

Portfolio highlights

• GenLayer — GenLayer is a platform that focuses on intelligent contracts.
• Spicenet — Spicenet enables universal access to the top DeFi venues across all networks, creating better financial outcomes for all.
• YeagerAI — YeagerAI is a pioneering AI research lab focused on developing technology that promotes sovereignty, transparency, and decentralization.

Portfolio highlights

• Wicrypt — Wicrypt is a dynamic organization that consistently allows its users to get paid by sharing their Wi-Fi.
• Gamic — Gamic is a community communication/collaboration app for gamers, creators, and web3 enthusiasts.The platform combines the advantages of blockchain technology with the conventional web2 community setup, creating a seamless environment where users can interact and enjoy the benefits of web3 advancements. This simplifies the process for web2communities to access and leverage the latest blockchain technology innovations, eliminating the need to navigate across various platforms.Today, the user experience is poor for online communities trying to engage with Web3 products and services because users are required to jump across different platforms. Sharing, trading, or managing Web3 assets on most traditional communication and social apps is hard. Addressing this is crucial because Web3 access means financial freedom and opportunity for many all around the world, especially in Africa. Gamic’s central mission is to encourage blockchain adoption as a means to improve the socio-economic opportunities available to global communities. We enable users to communicate and operate in the same place, with increased security and better monetisation opportunities.
• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.

Portfolio highlights

• Zuki Moba — The First E-Sports Game Empowering Gamers | Zuki Moba
• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.
• Zombie Worldz — Zombie World Z is a metaverse combining VR on the BSC, upgraded and developed based on a successful and established Zombie Idle Defense.

Portfolio highlights

• Biconomy — Blockchain transactions made simple. Enable Gasless meta-transactions, instant cross-chain transfers, easy layer 2 onboarding & zero failed transactions
• ZAP — ZAP offers a reputation-based token distribution protocol that supports fair rewards for user contributions within the Blast ecosystem. It enables users to participate in various projects through missions and seamless investment options. Additionally, ZAP is expanding its services to other blockchains and developing tools to simplify access toventure-capital-backed projects.
• Velvet Capital — Trade any crypto onchain - spot and perpetuals across 7 chains with AI-powered routing. Non-custodial DeFi trading terminal + AI trading bot. 100K+ traders.

Portfolio highlights

• Outer Ring — Enter a vast sci-fi universe where five species fight for dominance. Explore, craft, conquer and own your destiny in Outer Ring MMO.
• Infinity Arena — The place to connect players who love tactical card games or have passionate about collecting valuable and rare NFT cards.
• Ancient Kingdom — Ancient Kingdom is the first ancient martial arts game on the blockchain platform, pioneering the realization of real-time games on the blockchain platform.

Portfolio highlights

• Hybrid — Hybrid is a fintech company that offers a decentralized central AI tool with Web3's ecosystem of AI experts, agents, and data.
• Ajuna Network — Ajuna Network is a decentralized ecosystem for gamers and creators.
• Liquorice — Liquorice is a developer of a DeFi protocol that combines one-sided loan pools with a MEV-free trading engine.

Portfolio highlights

• Hydraverse — Hydraverse is a metaverse dragon fighting game developer, focusing on the development of a PVP dragon fighting game software.
• Outer Ring — Enter a vast sci-fi universe where five species fight for dominance. Explore, craft, conquer and own your destiny in Outer Ring MMO.
• Vee Finance — Bridge the gap between traditional banking and crypto Defi Earn fixed/flexible return on deposited assets

Portfolio highlights

• Zabo — Zabo is an API for connecting to any crypto exchange, wallet, protocol or account. Sign up for access to free API keys at Zabo.com
• Ballet — Ballet Crypto is a companion mobile app, which enables sending of cryptocurrency, checking market value and activating additional currencies. The use of the mobile app is completely optional, as you do not need it to receive and store your cryptocurrency safely.
• Ceramic Network — Ceramic Network is a provider of protocols for decentralized and composable data applications. The network decentralizes application databases, making data universally composable and reusable across applications. It consists of three core parts: a highly-scalable, decentralized infrastructure for data availability and consensus, a marketplace ofcommunity-created data models, and a suite of standard APIs for storing, updating, and retrieving data from those models.

Portfolio highlights

• XOCIETY — The XOCIETY metaverse is being developed by a well-established team of over 50 developers with decades of experience in the tech and web2 gaming fields.
• The FishVerse — FishVerse combines GameFi, AI, and blockchain technology, allowing players to fish in a dynamic open environment from their own homes.
• NXI — Nexus Interactive gives collective growth and accrued value to its ecosystem.

Portfolio highlights

• BullPerks — BullPerks is a community of like-minded individuals who want to leverage their power and invest together in the best projects on equal terms with VCs.
• Hashflow — Tight spreads. Zero slippage. MEV-resistant.
• Joystream — Joystream is a block chain-based, decentralized video platform.

Portfolio highlights

• Pixelverse — Pixelverse is a blockchain-based, pixelated P2E game.
• Mavryk Dynamics — Mavryk Dynamics simplifies trading real-world assets (RWA) and using decentralized finance (DeFi).
• Swarm Network — Swarm Network is a decentralized network for owning, controlling, and monetizing AI agents.

Portfolio highlights

• SolRazr — SolRazr is the first decentralized developer ecosystem for Solana, offering Launchpad, Accelerator, and Developer Tools.
• Exotic Markets — Exotic Markets bring wealth management and structured products out of the bank and in the decentralized finance world. Exotic Markets Maximise the investments with simple and sustainable products.
• Ignite Tournaments — Ready to take your mobile games to the next level? Join Ignite Tournaments and compete in real money esports tournaments. Download our app now and win big!

Portfolio highlights

• Portal to Bitcoin — The only custody-less interoperability protocol for Bitcoin. Swap native BTC, Ordinals, Runes with L2s and L1s
• Acta Finance — Acta Finance develops a complete DeFi ecosystem, EVM compatible, able to deploy and integrate EVM compatible networks.
• Monarch Wallet — As part of this journey, we will discontinue our wallet services effective July 1, 2024.

Portfolio highlights

• Dataiku — Dataiku is the Platform for AI Success that unites people, orchestration, and governance to turn AI investments into measurable business outcomes.
• TraceLink — TraceLink is the only network creation platform company that builds integrated business ecosystems with multienterprise applications - the true foundation for digitalization - delivering customer-centric agility and resiliency for end-to-end supply networks and leveraging the collective intelligence of entire industries.Delivering end-to-endsupply chain solutions, TraceLink's Opus Platform enables speed of innovation and implementation with an open partner model for no-code and low-code development of solutions and applications.With headquarters in Massachusetts, TraceLink has six global offices through North America, South America, Europe, and Asia.
• Nuvemshop — Nuvemshop provides entrepreneurs and SMBs with the tools to set up, manage, and promote their online business easily from any device.With the suite of tools around payments, shipping, inventory management, and marketing provided by the company, owners are enabled to participate in the e-commerce market, ramp up their sales, reduce costs, andprovide their end customers with a shopping experience.In 2011, co-founders Alejandro Alfonso, Santiago Sosa, Jose Abuchaem, Martin Palombo, and Alejandro Vazquez established Nuvemshop in 2011.

Portfolio highlights

• NEAR — NEAR is the unified commerce layer for unlocking asset liquidity and empowering agents to autonomously transact.
• TG DAO 3.0 — TG DAO 3.0 is TG Ecosystem's launchpad for investing in conventional and crypto startups. All launchpad investors are considered to be co-owners and take part in the decision-making process for the launchpad functions. TG DAO 3.0 is a new crowdfunding blockchain launchpad on the TG Ecosystem that combines decentralized and centralizedinvesting, attracts mechanisms, and provides comprehensive support for startups.
• Shiden Network — Shiden Network is a multi-chain decentralized application layer on Kusama Network. Kusama Relaychain does not support smart contract functionality by design - Kusama Network needs a smart contract layer. This is where Shiden Network comes in. Shiden supports Ethereum Virtual Machine, WebAssembly, and Layer2 solutions from day one. The platform supports various applications like DeFi, NFTs and more.

Portfolio highlights

• Polygen — Polygen provides a breath of fresh air in the world of blockchain launchpads. Current solutions all foster innovation on a specific blockchain, but they also look and operate the same. Fueling innovation in this industry requires the removal of all intermediaries and gatekeepers. Additionally, there is a need for more transparency, automatedprocesses, and post-launch support.
• Planet Sandbox — Planet Sandbox is the third-person NFT sandbox game that powers players with limitless building tools to customize their own worlds and design game modes. It allows players to build and own arenas to fight other players in different game modes using their own NFT weapons and accessories.
• Ignite Tournaments — Ready to take your mobile games to the next level? Join Ignite Tournaments and compete in real money esports tournaments. Download our app now and win big!

Portfolio highlights

• Demole — Demole is a play to earn NFT gamification platform.
• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.
• Radom — A Decentralised Network for Coordination of Cloud Applications and Connected Assets

Portfolio highlights

• IndiGG — IndiGG is an NFT based play-to-earn game in the web3 frontier. IndiGG is the India sub-decentralized autonomous organization(subDAO) of YGG.
• XY Finance — XY Finance is a leading cross-chain bridge aggregator that operates on 17+ EVM chains including zkSync, Linea, Arbitrum & Optimism, making bridging as easy as possible.
• Party Icons — Party Icons is a web3 mobile gaming platform. Its mission is to blend the social glue of party games with the intensity of extraction shooters.

Portfolio highlights

• Sidus Heroes — gaming company
• Zombie Worldz — Zombie World Z is a metaverse combining VR on the BSC, upgraded and developed based on a successful and established Zombie Idle Defense.
• CryptoVsZombie — CryptoVsZombie is the ultimate crypto tower defence in which players are required to multitask in both offensive and defensive modes.

Portfolio highlights

• Munily — Munily, a proptech software, Is redefining security and administration in residential communities by centralizing all communications.
• Shippify — Shippify is an innovative logistics service that connects businesses with a diverse network of drivers & 3PLs to provide same day delivery . Shippify is backed by strategic leading venture capital and angel investors. Currently available in Brasil, Mexico, Chile and Ecuador. The company was founded in 2014.

Portfolio highlights

• Amnis Finance — Stake APT on the best liquid staking protocol on Aptos to receive daily rewards with an attractive APR of 3%.
• Velvet Capital — Trade any crypto onchain - spot and perpetuals across 7 chains with AI-powered routing. Non-custodial DeFi trading terminal + AI trading bot. 100K+ traders.
• NXI — Nexus Interactive gives collective growth and accrued value to its ecosystem.

Portfolio highlights

• Dmail — Dmail Network is a decentralized mailbox that provides a safe and private environment for users' communication, storage, tokens, and NFTs. The company was founded by Mittal S. and Lucas L. in 2021.
• OMNIA Protocol — OMNIA Protocol offers a secure and private infrastructure for accessing blockchain technology. It provides high availability RPC endpoints for Ethereum, ensuring users can connect to the blockchain without being traced or monitored. The company focuses on delivering a compliant environment for handling personal data, including blockchain addressesand transactional information. OMNIA Protocol aims to democratize access to blockchain infrastructure, challenging the current concentration of this access among a few corporations. It supports various blockchains, including Bitcoin, Binance, Avalanche, Polygon, Arbitrum, and Optimism, through its platform, offering secure Arbitrum RPC Nodes features.
• Cumulus Encrypted Storage System (CESS) — CESS revolutionizes AI, DeSci, RWA, Enterprise, and more with secure, transparent, and traceable data solutions. Delivering AI computing and data infrastructure, CESS enables data privacy and sovereignty with a focus on AI Agent applications and frameworks.

Portfolio highlights

• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.
• Amyl Therapeutics — Amyl Therapeutics is a preclinical stage biotechnology company. Amyl Therapeutics uses a novel mechanism to bind to the amyloid fold of toxic protein aggregates of various types, including antibody light chain (AL) or transthyretin (TTR) aggregates, which accumulate in peripheral organs to cause systemic amyloidosis diseases, but also amyloid-β(Aβ), Tau, and α-synuclein aggregates, which accumulate in the brain to cause Alzheimer's and Parkinson's diseases.

Portfolio highlights

• PERL.eco — The Planetary Ecosystem Registration Ledger will be a dedicated blockchain for real-world ecological assets through tokenizing carbon credits and biodiversity, NFTs and decentralised (DeFi) rewards.
• Meter.io — Meter.io is a base layer hybrid consensus protocol built to address the volatility, scaling and interoperability problems in the existing cryptocurrencies.
• Injective — Explore Injective: the high-performance blockchain powering decentralized finance, governance, and next-gen Web3 apps with unmatched speed and scale.

Portfolio highlights

• Munily — Munily, a proptech software, Is redefining security and administration in residential communities by centralizing all communications.

Portfolio highlights

• Bluwhale — Unlock Web3 Wallet Potential with AI Insights. Supercharge Your Business Growth
• Novastro — Novastro is a Layer 2 chain for RWAs powered by AI that integrates MoveVM and EigenLayer AVS, delivering Ethereum-level security and Move’s scalability to unlock tokenised yield opportunities across RWAs & DeFi protocols.
• BluWhale — BluWhale's mission is to leverage AI and ML to allow game developers to focus on ways to improve the game rather than wrangling and making sense of astronomical amounts of data. BluWhale's smart automation will do the heavy lifting usually reserved for data analysts and data scientists all in the background, and surface actionable insight

Portfolio highlights

• Eywa — Founded in 2021, EYWA helps Web3 projects scale up by enabling them to operate, get listed, and traded on all connected blockchain networks with a single liquidity pool. Additionally, EYWA provides a truly decentralized data protocol for secure messaging.In partnership with Curve Finance, one of the largest decentralized exchanges, EYWA isintroducing a new paradigm of non-algorithmic cross-chain assets aimed at solving the problem of liquidity fragmentation. Their cross-chain protocol stands out as the most decentralized solution in the market.- Received 6 grants from biggest L1/L2 blockchain networks including NEAR Foundation, Aurora, Harmony One, Algorand, Boba Network, and others - Winning hackathons: Ethglobal Marketmake, Polygon’s BUIDL IT hackathon, Metis hackathon
• TG DAO 3.0 — TG DAO 3.0 is TG Ecosystem's launchpad for investing in conventional and crypto startups. All launchpad investors are considered to be co-owners and take part in the decision-making process for the launchpad functions. TG DAO 3.0 is a new crowdfunding blockchain launchpad on the TG Ecosystem that combines decentralized and centralizedinvesting, attracts mechanisms, and provides comprehensive support for startups.
• GoFungibles — GoFungibles is a cross-chain state-of-the-art NFT marketplace equipped with all the existing features of conventional NFT marketplaces but augmented with DeFi and gamified components.

Portfolio highlights

• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• Kuri — Kuri is a healthtech company that uses AI for revenue cycle management services at hospitals, laboratories, and clinics.
• Yuno — A fast checkout that integrates your company to the payments and fraud ecosystem.
• Bia Energy — Bia Energy engages in energy marketing.

Portfolio highlights

• Anoma — A sovereign, proof-of-stake blockchain protocol that enables private, asset-agnostic cash and private bartering among any number of parties.
• Keplr — Introducing the first, and leading, IBC-enabled wallet for Cosmos and beyond
• Datachain — Datachain is a tech company that revolutionizes blockchain interoperability and stablecoin settlement. we aim to make it possible for the world to interact as one network, making it easier to use a variety of services.

Portfolio highlights

• 375ai — 375ai is an edge data intelligence network on Solana that provides advanced real-time data collection and analysis to power a smarter, more connected world.
• Beam — Beam enables you to send and receive payments with speed, efficiency, and security like never before.
• Spaceport Technologies — Accelerating the growth of the next digital economy

Portfolio highlights

• Double — Double is a software platform that helps users to build, automate, and analyze investment portfolio for retail investors.
• Mentra — Mentra is a wearable technology company that develops smart glasses based on augmented reality and AI interface technologies.
• Volition — Volition is the largest marketplace of industrial components, built just for hardware teams. We make it easy to find and purchase off-the-shelf parts.

Portfolio highlights

• GAMES.GG — Discover 1,500+ games with honest reviews, expert guides, and daily gaming news across PC, console, and mobile. Find your next favorite game on Steam, Epic Games, PlayStation, Xbox, and Nintendo.
• Flappy Bird — Flappy Bird Foundation is to uphold the Flappy Bird intellectual property and further the Flappy Bird heritage. The Foundation accurately restores our vintage and nostalgic gameplay while adding new features to give back to the worldwide fan base that started the craze.
• Community Labs — Community Labs is a software development company and venture studio focused on accelerating developer tools, use cases, and adoption of Arweave and AO.

Portfolio highlights

• Fjord Foundry — Fjord enables teams the ability to openly and fairly generate liquidity by connecting inspired projects with passionate supporters via Liquidity Bootstrapping Pools.
• Zaros Finance — Zaros is a protocol that provides efficient liquidity, boosts staking rewards from LSTs, and aims to become the preferred liquidity hub for on-chain derivatives.
• Layer Social Labs — A home for global companionship and endless entertainment. Post More, Play More, Earn More.

Portfolio highlights

• Ignite Tournaments — Ready to take your mobile games to the next level? Join Ignite Tournaments and compete in real money esports tournaments. Download our app now and win big!