Top 50 Software Startup Investors in Panama (August 2026)

Portfolio highlights

• Rivalz Network — Join the connectivity infrastructure between AI Agents, DeFAI and Markets.
• The Arena — A next gen SocialFi app redefining how creators connect, engage, and monetize their content.
• Sigma Computing — Sigma is the only BI analytics tool purpose-built for your cloud data warehouse. Uniquely scalable, with an experience you already know: the spreadsheet.

Portfolio highlights

• OP_NET — OPNET is a Bitcoin Layer 1 metaprotocol that enables smart contracts to function directly on the Bitcoin blockchain, without the use of sidechains or Layer 2 solutions.
• Watch.fun — Luxury watch drops. Win a Rolex for as little as $7, drops weekly. Certified by Wristcheck. Backed by @TheSpartanGroup @SolanaVentures @BigBrainVC and more...
• Space — The first leveraged prediction market on @solana

Portfolio highlights

• EBR Systems — EBR aims for outstanding treatment of cardiac rhythm diseases with an innovative leadless therapy.
• Cardiac Dimensions — Cardiac Dimensions, Inc. is a medical device company developing novel interventional tools for the treatment of heart failure and the related condition of mitral valve regurgitation. Our product, the Carillon® Mitral Contour System®, is a groundbreaking, non-surgical device developed to treat functional mitral valve regurgitation. Our system uses acatheter based approach to reshape the mitral valve and reduce mitral regurgitation.
• Ignite Tournaments — Empower content creators to launch custom quest lines, track fan engagement, and manage premium subscription communities.

Portfolio highlights

• PERL.eco — The Planetary Ecosystem Registration Ledger will be a dedicated blockchain for real-world ecological assets through tokenizing carbon credits and biodiversity, NFTs and decentralised (DeFi) rewards.
• A-World — Welcome to Animal World, a battle game based on #BNBCHAIN's super metaverse card tower defense. By setting up a hero tower to destroy monsters.
• NeuronX — The First AI-Driven Lending Protocol on @dfinity

Portfolio highlights

• OpenPad AI — OpenPad - The 1st AI Decentralized Launchpad
• Stabble — stabble is a protocol revolutionizing liquidity pools by introducing protocol-managed and arbitrage pools. This allows stabble to tackle critical inefficiencies prevalent within Solana's decentralized exchanges.
• AI Cross Matrix — AI Cross Matrix is a DeFi platform that makes the crypto economy simple by streamlining the exchange process with useful solutions.

Portfolio highlights

• SnakeLite — 10-min prediction markets on Hyperliquid whale positions, BTC and ETH. Predict up or down. Settle onchain. From the 100M+ download SnakeLite game.
• Sophon — Soph(+) is a tech studio building novel consumer experiences in crypto and ai. we build, own, and ship our own products, starting with pyre.
• A.A.A C(H+A)RM — AAA C(H+A)RM (Autonomous AI Agents Launchpad & Layer3) is the first AI-first, agent-focused orchestration platform.

Portfolio highlights

• MSafe — MSafe offers the most secure, decentralized, scalable Web3 non-custodial, multi-signature solution built on Move, ideal for dApp developers to use for treasury management, token management, smart contract development, blockchain protocol admin control, live on Aptos
• Polysights — Leverage intelligence to optimize your strategy on @Polymarket
• Turtle Club — Aggregated, diligenced, personalized onchain yield management.

Portfolio highlights

• Ignite Tournaments — Empower content creators to launch custom quest lines, track fan engagement, and manage premium subscription communities.

Portfolio highlights

• ShoeFy — ShoeFy is a decentralized project that combines nonfungible tokens (NFTs) and fungible tokens (FTs) on one platform to add new utility layers to NFTs.
• CryptoTanks — CryptoTanks is a play-to-earn platform where every NFT is usable in a gamified DeFi ecosystem. With the tanks, the player earns money and plays games partially owned and operated by their players. Earn tank tokens by playing and use them to decide the future of the game. They offer design and prizes that come with gamified yield farming.
• Astra Guild Ventures — Astra Guild Ventures is one of the world's play-to-earn gaming guilds. Astra Guild Ventures is bridging the gap between players and investors in order to capitalize on the growth of non-traditional games.

Portfolio highlights

• Capx — Capx's mission is to accelerate the flow of capital through the private markets, thereby enhancing global capital allocation. With secondary market and enterprise solutions, Capx combines high-quality collections of opportunities with efficient access for institutions and individual investors.
• DeepSafe — The world's first Cryptographic Random AI Verification Network for trustless verification of any on-chain and off-chain messages.
• aPriori — aPriori is a monad-native MEV infrastructure and liquid staking mechanism developed for parallel executions.

Portfolio highlights

• DHL — DHL is a division of the German logistics company Deutsche Post DHL that provides international express mail services. Deutsche Post is a large-scale logistics company operating around the world. DHL provides world market services both in sea and air mail.DHL was primarily interested in offshore and inter-continental deliveries, but the successof FedEx prompted its own intra-U.S. expansion starting in 1983. DHL aggressively expanded to countries that could not be served by any other delivery service, including the Soviet Union, Eastern Bloc, Iraq, Iran, China, Vietnam, and North Korea.Deutsche Post then effectively absorbed DHL into its Express division, while expanding the use of the DHL brand to other Deutsche Post divisions, business units and subsidiaries.Originally founded in 1969 to deliver documents between San Francisco and Honolulu, the company expanded its service throughout the world by the late 1970s. DHL was founded in 1969 and is based in Bonn.
• ShoeFy — ShoeFy is a decentralized project that combines nonfungible tokens (NFTs) and fungible tokens (FTs) on one platform to add new utility layers to NFTs.

Portfolio highlights

• Treyee — Engineering AI solutions and products that empower enterprises to achieve results through adaptive business and personal automation

Portfolio highlights

• myco — myco is a content streaming super dApp that smoothly integrates AVOD and SVOD capabilities into a decentralized ecosystem.
• Metametaverse — Discover the future of virtual worlds with our metaverse platform. Explore, create and monetize your own metaverse experiences in a seamless and secure manner. Join the cosmic system of metaverses today.
• Ignite Tournaments — Empower content creators to launch custom quest lines, track fan engagement, and manage premium subscription communities.

Portfolio highlights

• Treyee — Engineering AI solutions and products that empower enterprises to achieve results through adaptive business and personal automation

Portfolio highlights

• 3VO — Bring Your Business On-chain. The easiest way to launch, grow, and own your brand with AI + Web3 tools - all in one simple, social platform.

Portfolio highlights

• GAMES.GG — Discover 1,500+ games with honest reviews, expert guides, and daily gaming news across PC, console, and mobile. Find your next favorite game on Steam, Epic Games, PlayStation, Xbox, and Nintendo.
• Sumer Money — Sumer Money is a cross-chain synthetic assets protocol that enables composable Defi across blockchains.
• SYNTRA — Live AI trading system. Real-time execution, risk-managed positions, public trade feed. Signals, performance, transparency.

Portfolio highlights

• SQR3D — Transform your idea into 3D assets at scale. Smart Contract Automation for 3D Designs with SQR3D.
• Reitio Protocol — We’re creating an effortless way for everyone to create custom metaverse assets visually via an intuitive and codeless templates-based design toolkit, introducing reitio protocol.
• Genesis Shards — Crafting a whole new suite of NFT powered products across multiple blockchains

Portfolio highlights

• Meta Pool — Meta Pool is a multi-chain, liquid staking-based ecosystem with Vote-to-Earn DAO governance.
• Amnis Finance — Stake APT on the best liquid staking protocol on Aptos to receive daily rewards with an attractive APR of 2%.
• Velvet Capital — Trade any crypto onchain - spot and perpetuals across 7 chains with AI-powered routing. Non-custodial DeFi trading terminal + AI trading bot. 100K+ traders.

Portfolio highlights

• Vangrid — Vangrid operates as a decentralized physical infrastructure network.
• Dow Protocol — An E-Commerce Financing RWA Platform on @BNBCHAIN, facilitating assets trusted by the world's largest banks. Lead invested by @mhventures @Maple_block
• Ceramic Network — We've joined @textileio to build the first open intelligence network for AI agents. Follow us there.

Portfolio highlights

• Wizzwoods — 1st pixel farm game integrates interchain capabilities with a SocialFi twist.
• SuperIntent — SuperIntent is a cryptocurrency AI app that streamlines on-chain earning tactics. Developed on a multi-agent framework with abundant yield sources.
• SuperGaming — At SuperGaming, we are putting India on the global gaming map.

Portfolio highlights

• Alphea — ALPHEA is an AI-native execution OS that awakens intelligence across every surface.
• Dow Protocol — An E-Commerce Financing RWA Platform on @BNBCHAIN, facilitating assets trusted by the world's largest banks. Lead invested by @mhventures @Maple_block
• Fortune Protocol — Fortune Protocol brings the age- old tradition of fortune cookies to the modern prediction market.

Portfolio highlights

• AEON — Powering #agenticeconomy #x402 | AEON is settlement layer bridging autonomous AI interactions (A2A & A2M) with real-world value flows. Backed by @yzilabs $AEON
• KOR Protocol — KOR Protocol is a decentralized intellectual property (IP) infrastructure designed to empower creators, protect rights, and enable seamless collaboration and monetization of IP assets across various industries, including music, film, TV, gaming, and art. Backed by notable entities like Animoca Brands, Republic, Niantic, Sfermion, Solana, andprominent creators such as Black Mirror, Disclosure, deadmau5, and Richie Hawtin, KOR leverages blockchain, AI, and DeFi to offer a transparent, efficient, and scalable environment for IP expansion.
• Limited — Secure your treasury and scale your business globally with a truly self-custodial account that only you control. No banks. No middlemen.

Portfolio highlights

• Outer Ring — Enter a vast sci-fi universe where five species fight for dominance. Explore, craft, conquer and own your destiny in Outer Ring MMO.
• Infinity Arena — The place to connect players who love tactical card games or have passionate about collecting valuable and rare NFT cards.
• Ancient Kingdom — Ancient Kingdom is the first ancient martial arts game on the blockchain platform, pioneering the realization of real-time games on the blockchain platform.

Portfolio highlights

• Fjord Foundry — Fjord enables teams the ability to openly and fairly generate liquidity by connecting inspired projects with passionate supporters via Liquidity Bootstrapping Pools.
• Zaros Finance — Zaros is a protocol that provides efficient liquidity, boosts staking rewards from LSTs, and aims to become the preferred liquidity hub for on-chain derivatives.
• Layer Social Labs — A home for global companionship and endless entertainment. Post More, Play More, Earn More.

Portfolio highlights

• Wicrypt — Wicrypt is a dynamic organization that consistently allows its users to get paid by sharing their Wi-Fi.
• Gamic — Africa's biggest gaming guild.
• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.

Portfolio highlights

• Munily — Munily, a proptech software, Is redefining security and administration in residential communities by centralizing all communications.

Portfolio highlights

• Zecrey — Zecrey is a digital asset privacy protocol provider, based on the application of the Sigma protocol.
• Vee Finance — Bridge the gap between traditional banking and crypto Defi Earn fixed/flexible return on deposited assets
• The Unfettered — The Unfettered is a blockchain PC game.

Portfolio highlights

• Hitcard — Hitcard is a trendy card culture brand that uses technology to upgrade card-like consumer products.
• Stems Labs — community and platform for collaborative creativity
• MetaverseGo — MetaverseGo is a web 3.0 app that offers easy access to Play-and-Earn Games, Guilds, NFTs, and Decentralized Applications allowing users to own assets, connect with industry players, and use their earnings across multiple payment platforms.

Portfolio highlights

• Kuri — Kuri is a healthtech company that uses AI for revenue cycle management services at hospitals, laboratories, and clinics.
• Seeri — Easy, affordable, and comprehensive: personalized catalog, sales tracking, credit, inventory management, and more, all in one place.
• 4.screen — The Driver Interaction Platform. Connect with drivers in real-time to deliver personalized and targeted campaigns.

Portfolio highlights

• Kapkap — Kapkap is a web3 platform that uses AI for attention based value distribution in gaming.
• SuperIntent — SuperIntent is a cryptocurrency AI app that streamlines on-chain earning tactics. Developed on a multi-agent framework with abundant yield sources.
• Inference Labs — AI hyperscale on decentralized networks - We provide certainty for on-chain AI

Portfolio highlights

• Munily — Munily, a proptech software, Is redefining security and administration in residential communities by centralizing all communications.
• Shippify — Shippify is an innovative logistics service that connects businesses with a diverse network of drivers & 3PLs to provide same day delivery . Shippify is backed by strategic leading venture capital and angel investors. Currently available in Brasil, Mexico, Chile and Ecuador. The company was founded in 2014.

Portfolio highlights

• Capx — Capx's mission is to accelerate the flow of capital through the private markets, thereby enhancing global capital allocation. With secondary market and enterprise solutions, Capx combines high-quality collections of opportunities with efficient access for institutions and individual investors.
• Noodles Finance — The no-brainer trading platform for Sui.
• YOAKE Entertainment — YOAKE Entertainment is a music studio that specializes in the planning, production, and development of entertainment content.

Portfolio highlights

• Delabs Games — At Delabs Games, we want to create fun games that last a thousand years.
• PublicAI — PublicAI is a Web3 distributed AI training network that helps people to earn rewards by contributing data work.
• Power Protocol — The ecosystem for blockchain entertainment. Fueled by $POWER. Launch Partner: @Fableborne Power Up Your Play

Portfolio highlights

• Demole — Demole is a play to earn NFT gamification platform.
• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.
• Radom — A Decentralised Network for Coordination of Cloud Applications and Connected Assets

Portfolio highlights

• Datagram — Datagram is an AI-driven, decentralized infrastructure platform operating as a DePIN baselayer. The company provides a live, scalable node network for launching custom DePIN networks and real-world decentralized applications, with cost savings over traditional cloud providers.
• Ooga Booga — Multichain Liquidity Aggregator
• Accountable — Accountable is the new standard for real-time financial verification. Prove assets and liabilities privately, powered by the Data Verification Network (DVN).

Portfolio highlights

• Aire — The income assessment platform that leverages first-party data. Access real-time confidence in the stated income of any consumer.
• Questflow — Questflow Labs seeking to give customers with an all-in-one solution for user intent perception and distribution, AI agentic workflow automation, and human-AI cooperation. Questflow Labs is pioneering a novel approach to decentralized AI agentic workflow.
• Flare — Flare equips your team to shut down cybercrime before it escalates. Detect, prioritize, and remediate external cyber threats with automated Threat Exposure Management.

Portfolio highlights

• BRKT — Join the fun on BRKT! Make predictions on sports, pop culture, and more!
• GAIB — GAIB is the economic foundation for the future of artificial intelligence and computers. GAIB is a crypto-AI platform under development that tokenize GPUs, making AI computing—the processing power required to train and run AI models—more accessible.
• Yala — Yala operates a multi-token system and unlocks a thriving and interconnected DeFi ecosystem on Bitcoin​.

Portfolio highlights

• BRKT — Join the fun on BRKT! Make predictions on sports, pop culture, and more!
• RedStone — RedStone delivers frequently updated, reliable and diverse data for your dApp and smart contracts.

Portfolio highlights

• Elusiv — Elusiv offers compliance in mind with next-generation privacy solutions for a better Web3.
• TipLink — TipLink helps send crypto with a link. Someone with crypto can create a account and send that link to anyone over any platform. It’s like buying a gift card, connect the client's crypto wallet of choice and create a account by depositing how much they want to send.
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• NEAR — NEAR is the unified commerce layer for unlocking asset liquidity and empowering agents to autonomously transact.
• TG DAO 3.0 — TG DAO 3.0 is TG Ecosystem's launchpad for investing in conventional and crypto startups. All launchpad investors are considered to be co-owners and take part in the decision-making process for the launchpad functions. TG DAO 3.0 is a new crowdfunding blockchain launchpad on the TG Ecosystem that combines decentralized and centralizedinvesting, attracts mechanisms, and provides comprehensive support for startups.
• Shiden Network — Shiden Network is a multi-chain decentralized application layer on Kusama Network. Kusama Relaychain does not support smart contract functionality by design - Kusama Network needs a smart contract layer. This is where Shiden Network comes in. Shiden supports Ethereum Virtual Machine, WebAssembly, and Layer2 solutions from day one. The platform supports various applications like DeFi, NFTs and more.

Portfolio highlights

• AHAlife — AHAlife is a fashion-based e-commerce platform connecting designers, brands, and publishers to individuals. The company's mission is to connect the best the world has to offer with discerning individuals from around the world. It is a discovery shopping destination for curated lifestyle products that span design, technology, fashion, media,food, beauty, and travel. Its platform sits at the intersection of content, commerce, and curation.
• Greenphire — Greenphire is the leading provider of global financial lifecycle management solutions for clinical trials, delivering the most complete data and workflow automation from budgeting through analysis to drive unprecedented business insight and smarter trials.Since 2008, we have continued to set the standard for regulated global payment workflowautomation in clinical trials. The choice of industry leaders worldwide, Greenphire delivers proven performance, resulting in more efficient and more successful trials.
• Meteor Entertainment — Meteor Entertainment engages in developing and publishing video games. The company was incorporated in 2011 and is based in Seattle, Washington.

Portfolio highlights

• Zabo — Zabo is an API for connecting to any crypto exchange, wallet, protocol or account. Sign up for access to free API keys at Zabo.com
• Joystream — Joystream is a block chain-based, decentralized video platform.
• Ceramic Network — Ceramic Network is a provider of protocols for decentralized and composable data applications. The network decentralizes application databases, making data universally composable and reusable across applications. It consists of three core parts: a highly-scalable, decentralized infrastructure for data availability and consensus, a marketplace ofcommunity-created data models, and a suite of standard APIs for storing, updating, and retrieving data from those models.

Portfolio highlights

• Munily — Munily, a proptech software, Is redefining security and administration in residential communities by centralizing all communications.
• Momint — Momint is the Web3 investment platform of the future. The safest and easiest to use NFT marketplace in the world. Discover the real-world potential of NFTs.
• PropertyScout — PropertyScout is a proptech startup that builds an end-to-end rental and sale platform for owners, agents, buyers, and tenants. The startup is connecting over 1,800 agents and agencies with buyers, renters, and owners, servicing thousands of satisfied customers every month. PropertyScout leverages its database of more than 200,000 properties, itstechnology platform, and its centralized operations to digitize and automate 90% of the real estate transaction. This frees up agents’ time to professionally and efficiently communicate with buyers, renters, owners and co-agents to deliver outstanding service and close transactions faster. Providing a transparent and trusted experience, PropertyScout has quickly become the favorite go-to place for buying, selling, and renting real estate in Thailand, as proven by hundreds of five-star reviews.

Portfolio highlights

• Portal to Bitcoin — The only custody-less interoperability protocol for Bitcoin. Swap native BTC, Ordinals, Runes with L2s and L1s
• NAKA — Elly POS is an irreplaceable all-in-one device with multiple payment methods. Accepting cards, crypto and digital payments. Future-proof, transparent and secure.
• Acta Finance — Acta Finance develops a complete DeFi ecosystem, EVM compatible, able to deploy and integrate EVM compatible networks.

Portfolio highlights

• Starbots — Starbots is Solana's first-ever battle NFT game.
• Linear — Linear allows the user to manage software development and track bugs. Built for speed and efficiency.The founders started Linear from their own frustrations building software projects in successful high-growth companies like Airbnb, Coinbase and Uber. The founders wanted to create the tools that focus us and its team in making progress, not getin the way. Tools that are fast and efficient. Speed and performance were the main things Linear focuses on early on and keep focusing on that.
• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.

Portfolio highlights

• Revomon — CA: 0xaab09b5cd1694d12c8c980306f5e2f5d65b00e1c Join the community here https://t.co/AkzLXfXr8s Backed by @Immutable
• MonoPolist — MonoPolist offers a cross-platform gaming universe with NFT features and rewards players with MONO and MOB tokens.
• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.

Portfolio highlights

• ZAP — ZAP offers a reputation-based token distribution protocol that supports fair rewards for user contributions within the Blast ecosystem. It enables users to participate in various projects through missions and seamless investment options. Additionally, ZAP is expanding its services to other blockchains and developing tools to simplify access toventure-capital-backed projects.
• Galaxis — Galaxis maintains an engagement platform that aims to transform and strengthen the relationship between creators and their communities. The company's platform assists creators by injecting simple NFTs with unique utilities that can expand and alter.
• Velvet Capital — Trade any crypto onchain - spot and perpetuals across 7 chains with AI-powered routing. Non-custodial DeFi trading terminal + AI trading bot. 100K+ traders.

Portfolio highlights

• CESS — CESS is a blockchain-based, decentralized Layer-1 infrastructure that integrates distributed storage, a high-speed content delivery network.
• Dmail — Dmail Network is a decentralized mailbox that provides a safe and private environment for users' communication, storage, tokens, and NFTs. The company was founded by Mittal S. and Lucas L. in 2021.
• Cumulus Encrypted Storage System (CESS) — CESS revolutionizes AI, DeSci, RWA, Enterprise, and more with secure, transparent, and traceable data solutions. Delivering AI computing and data infrastructure, CESS enables data privacy and sovereignty with a focus on AI Agent applications and frameworks.

Portfolio highlights

• Hawksight — Hawksight provides a protocol that optimizes yield on Solana DeFi. It offers a concentrated liquidity yield optimizer with self-custodial and automated market-making strategies. Users can earn optimized yields from Solana's top DeFi protocols and manage their positions in one platform. Hawksight aims to build Solana's largestdecentralized finance yield aggregator protocol.
• Hybrid — Hybrid is a fintech company that offers a decentralized central AI tool with Web3's ecosystem of AI experts, agents, and data.
• Liquorice — We're thrilled to announce our $1.2M pre-seed round, led by @greenfield_cap and with participation from @l2iterative, @polymorphiccap, @HoradrimCapital, and @HASHCIB. Angel investors include founders from @1inch.

Portfolio highlights

• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.
• Amyl Therapeutics — Amyl Therapeutics is a preclinical stage biotechnology company. Amyl Therapeutics uses a novel mechanism to bind to the amyloid fold of toxic protein aggregates of various types, including antibody light chain (AL) or transthyretin (TTR) aggregates, which accumulate in peripheral organs to cause systemic amyloidosis diseases, but also amyloid-β(Aβ), Tau, and α-synuclein aggregates, which accumulate in the brain to cause Alzheimer's and Parkinson's diseases.