Top 45 Blockchain VC Funds & Investors in Panama (October 2026)

Portfolio highlights

• OP_NET — OPNET is a Bitcoin Layer 1 metaprotocol that enables smart contracts to function directly on the Bitcoin blockchain, without the use of sidechains or Layer 2 solutions.
• Watch.fun — Open boxes, collect watches. Pull a Rolex today. Authenticated by Wristcheck. Backed by @SolanaVentures
• Space — Space is a leveraged prediction market platform built on Solana, designed to reward users for accurate insights while enabling efficient capital flow through competitive forecasting, combining high-performance blockchain infrastructure with advanced market mechanisms to create a transparent, scalable, and engaging environment for decentralizedprediction and informed decision-making.

Portfolio highlights

• Rivalz Network — Join the connectivity infrastructure between AI Agents, DeFAI and Markets.
• The Arena — A next gen SocialFi app redefining how creators connect, engage, and monetize their content.
• Sigma Computing — Sigma is the only BI analytics tool purpose-built for your cloud data warehouse. Uniquely scalable, with an experience you already know: the spreadsheet.

Portfolio highlights

• EBR Systems — EBR aims for outstanding treatment of cardiac rhythm diseases with an innovative leadless therapy.
• Cardiac Dimensions — Cardiac Dimensions, Inc. is a medical device company developing novel interventional tools for the treatment of heart failure and the related condition of mitral valve regurgitation. Our product, the Carillon® Mitral Contour System®, is a groundbreaking, non-surgical device developed to treat functional mitral valve regurgitation. Our system uses acatheter based approach to reshape the mitral valve and reduce mitral regurgitation.
• Ignite Tournaments — Empower content creators to launch custom quest lines, track fan engagement, and manage premium subscription communities.

Portfolio highlights

• Superlogic — OneOf is the mass-consumer Web3 company connecting the next 100M non-crypto-native fans to iconic brands, artists, and athletes. OneOf technology enables global brands and enterprises to reimagine commerce, loyalty and engagement, allowing consumers to seamlessly collect or trade digital assets with no prior crypto expertise. Deeply committed to a sustainable and inclusive blockchain future, minting digital assets on OneOf's platform uses up to 2 million times less energy than previous generation proof-of-work networks, and costs up to 99% less in gas fees. A leader in diversity, over 80% of the collections curated by OneOf come from minority or female creators.
• PERPTools — PERPTools combines crypto perpetual trading with activity points and risk-free market predictions.
• Slinky Network — Slinky Network provides an on-chain marketplace and payment protocol that connects AI agents and applications with third-party APIs. The company offers the SlinkyLayer platform, which wraps developer endpoints as discoverable skills and exposes them through an x402 pay-per-execution interface. Each API call triggers a non-custodial on-chainmicropayment, settling in the same request loop using networks such as Base and BNB Chain. Developers set prices, earn a defined revenue share, and receive instant payouts to their wallets without subscriptions or custodial holds. AI agents authenticate via wallet signatures, enabling autonomous, machine-to-machine access and payment without traditional logins or credit cards. The platform also records call ratings on-chain to provide portable, verifiable reputation for services.

Portfolio highlights

• GAMES.GG — Discover 1,500+ games with honest reviews, expert guides, and daily gaming news across PC, console, and mobile. Find your next favorite game on Steam, Epic Games, PlayStation, Xbox, and Nintendo.
• Sumer Money — Sumer Money is a cross-chain synthetic assets protocol that enables composable Defi across blockchains.
• SYNTRA — Live AI trading system. Real-time execution, risk-managed positions, public trade feed. Signals, performance, transparency.

Portfolio highlights

• myco — myco is a content streaming super dApp that smoothly integrates AVOD and SVOD capabilities into a decentralized ecosystem.
• Metametaverse — Discover the future of virtual worlds with our metaverse platform. Explore, create and monetize your own metaverse experiences in a seamless and secure manner. Join the cosmic system of metaverses today.
• Ignite Tournaments — Empower content creators to launch custom quest lines, track fan engagement, and manage premium subscription communities.

Portfolio highlights

• Quotr.ai — Quotr.ai is the all-in-one pre-construction engine built to bridge the costly "takeoff-to-transaction" gap for modern subcontractors, contractors and developers. The San Francisco-based platform serves every construction trade by consolidating fragmented workflows into a single workspace. Instead of bouncing between disjointed tools,users can seamlessly transition from advanced AI takeoffs and estimates to competitive bidding, material procurement, and developer proformas. To directly improve project margins, Quotr.ai integrates dynamic material list matching, connecting users with diverse suppliers to source materials cheaper and faster. Quotr.ai enables teams to slash material costs by up to 40% and cut estimation time by 90%, bringing modern, high-ROI software to one of the world's largest industries. Backed by Llama Ventures, Quotr.ai is rapidly becoming the platform of choice for forward-thinking construction firms with a mission to make pre-construction faster, easier, and more accurate.
• AEON — Powering #agenticeconomy #x402 | AEON is settlement layer bridging autonomous AI interactions (A2A & A2M) with real-world value flows. Backed by @yzilabs $AEON
• KOR Protocol — KOR Protocol is a decentralized intellectual property (IP) infrastructure designed to empower creators, protect rights, and enable seamless collaboration and monetization of IP assets across various industries, including music, film, TV, gaming, and art. Backed by notable entities like Animoca Brands, Republic, Niantic, Sfermion, Solana, andprominent creators such as Black Mirror, Disclosure, deadmau5, and Richie Hawtin, KOR leverages blockchain, AI, and DeFi to offer a transparent, efficient, and scalable environment for IP expansion.

Portfolio highlights

• Wizzwoods — 1st pixel farm game integrates interchain capabilities with a SocialFi twist.
• SuperIntent — SuperIntent is a cryptocurrency AI app that streamlines on-chain earning tactics. Developed on a multi-agent framework with abundant yield sources.
• SuperGaming — At SuperGaming, we are putting India on the global gaming map.

Portfolio highlights

• SnakeLite — 10-min prediction markets on Hyperliquid whale positions, BTC and ETH. Predict up or down. Settle onchain. From the 100M+ download SnakeLite game.
• Sophon — Soph(+) is a tech studio building novel consumer experiences in crypto and ai. we build, own, and ship our own products, starting with pyre.
• A.A.A C(H+A)RM — AAA C(H+A)RM (Autonomous AI Agents Launchpad & Layer3) is the first AI-first, agent-focused orchestration platform.

Portfolio highlights

• Alphea — ALPHEA is an AI-native execution OS that awakens intelligence across every surface.
• ForU AI — ForU AI operates as a real-world AI agent.
• Voran — Voran is a decentralized computing platform that develops an AI compute and intelligence ecosystem.

Portfolio highlights

• 375ai — 375ai is an edge data intelligence network on Solana that provides advanced real-time data collection and analysis to power a smarter, more connected world.
• XTAO — Publicly traded Bittensor company. Bridging TradFi and TAO. (TSXV: XTAO.U | OTC: XTAIF)
• Agentum — Agentum provides an autonomous economic layer built on the BNB Chain that enables AI agents to transact trustlessly with one another without human intervention. The protocol utilizes a combination of TEE confidential computing, zkVM verifiable evaluation, and specialized ERC standards to ensure secure task execution, portable agent reputations, andautomated escrow settlements. By aligning economic incentives at the protocol layer, it ensures that honest machine-to-machine commerce always carries higher payoffs than deceptive practices.

Portfolio highlights

• TITAN — Titan provides users with the best swap price by searching through Solana’s on-chain liquidity through trusted sources. It then deploys revolutionary routing algorithms based on cutting-edge mathematics to determine the best price a user can get when trading any token.
• assisterr — Enterprise-grade Specialized AI Agents for Business. Assisterr AI Lab builds domain-specific SLMs and AI Agents. Agent Tokenization as a Service (ATaaS) for AI startups.
• Splyce Finance — Liquidity for real assets. Yield for everyone else.

Portfolio highlights

• Zcash — Zcash offers total payment confidentiality, while still maintaining a decentralized network using a public blockchain. Unlike Bitcoin, Zcash transactions automatically hide the sender, recipient, and value of all transactions on the blockchain. Only those with the correct view key can see the contents. Users have complete control and can opt-in toprovide others with their view key at their discretion.Zcash transactions do not depend on the cooperation of other parties. Additionally, full nodes in the Zcash network only need to store a small persistent state.
• Grass — Affiliated with @grass
• Trasia Labs — Trasia is an Asia-first trading platform built on @HyperliquidX. Mobile app will be live soon. Trade Asia with Trasia.

Portfolio highlights

• Raven — Raven is a proprietary high-frequency algorithmic trading firm specializing in CeFi market making and DeFi liquidity provision.
• Jeeves Inc. — Pay for anything, anywhere, in your local currency. No fees. No interest. No personal guarantees. Mobile-first, built with your team in mind.
• Catchback Cards — Catchback Cards offers a platform for buying, selling, storing, and auctioning collectibles with pack opening and card-backed loan services.

Portfolio highlights

• CUDIS — The Olympian-trusted wearable coach for wellness, recovery & anti-aging. Join 250k+ global members to optimize your wellness today.
• ZAR — Accelerating stablecoin adoption for the next billion users living in countries with unstable money (backed by @a16zcrypto, @dragonflyvc, @coinbase, @vaneck_us)
• Ranger Finance — DeFi's command center. https://t.co/jq6FwIX0Xm

Portfolio highlights

• TipLink — TipLink helps send crypto with a link. Someone with crypto can create a account and send that link to anyone over any platform. It’s like buying a gift card, connect the client's crypto wallet of choice and create a account by depositing how much they want to send.
• Momentum — Building a global financial OS for the tokenized future // Backed by @SuiNetwork @Coinbase @Circle @Jump_ @OKX_Ventures // https://t.co/2dKR0MTrPq
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• Neosoul — NeoSoul uses an open architecture with autonomous agents operating under user-defined constraints to link agent intelligence, deterministic capital controls, and verifiable market execution.
• ORO — ORO is an AI-powered DeFi companion that lets users manage, trade, stake, lend, and research crypto assets through natural-language conversations, ORO aims to simplify onchain finance by bringing portfolio management and DeFi actions into one conversational interface.
• GAEA — GAEA is a decentralized artificial intelligence training network and data infrastructure platform focused on building a comprehensive multimodal emotional database.

Portfolio highlights

• The Arena — A next gen SocialFi app redefining how creators connect, engage, and monetize their content.
• Shipsi — Shipsi empowers any retailer with the ability to offer an easy “instant shipping” option on their checkout page—without worrying about logistics. They use existing infrastructure and last-mile delivery networks to help customers order now AND get it now. Shipsi was founded in 2017 and is headquartered in Austin, TX.
• Splyce Finance — Liquidity for real assets. Yield for everyone else.

Portfolio highlights

• Hitcard — Hitcard is a trendy card culture brand that uses technology to upgrade card-like consumer products.
• Stems Labs — community and platform for collaborative creativity
• MetaverseGo — MetaverseGo is a web 3.0 app that offers easy access to Play-and-Earn Games, Guilds, NFTs, and Decentralized Applications allowing users to own assets, connect with industry players, and use their earnings across multiple payment platforms.

Portfolio highlights

• Kapkap — Kapkap is a web3 platform that uses AI for attention based value distribution in gaming.
• SuperIntent — SuperIntent is a cryptocurrency AI app that streamlines on-chain earning tactics. Developed on a multi-agent framework with abundant yield sources.
• Inference Labs — AI hyperscale on decentralized networks - We provide certainty for on-chain AI

Portfolio highlights

• Composable Corp — Composable Corp is a blockchain financial application developer.
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• 5ire — 5ire is a blockchain network that brings sustainability, technology, and Innovation to build the 5th industrial revolution (5IR). The mission of the 5ire ecosystem is to embed the for-benefit paradigm at the heart of the blockchain, highly incentivize practices that align with the United Nations Sustainable Development Goals (SDGs), facilitate thetransition from the 4IR to 5IR and accelerate the implementation of the UN 2030 Agenda for Sustainable Development. The company's primary offering is 5ireChain, a layer one, sustainability-driven 5th generation blockchain that ensures adherence to the philosophy of 5IR, creating a net positive impact on the planet and serving humanity.
• Polygen — Polygen provides a breath of fresh air in the world of blockchain launchpads. Current solutions all foster innovation on a specific blockchain, but they also look and operate the same. Fueling innovation in this industry requires the removal of all intermediaries and gatekeepers. Additionally, there is a need for more transparency, automatedprocesses, and post-launch support.
• Ignite Tournaments — Empower content creators to launch custom quest lines, track fan engagement, and manage premium subscription communities.

Portfolio highlights

• OX.FUN — Trade Bitcoin, Ethereum and trending altcoin derivatives on the most FUN exchange around. Join OX.FUN today and earn up to 200% yield. Moo.
• AINN Layer2 — AINN Layer2 is a decentralized Bitcoin Layer2 network development.It promotes large-scale AI applications
• Sanctum — Stake SOL and earn optimized LST returns from JupSOL, bbSOL, and more, and launch your own custom LST and Solana validator.

Portfolio highlights

• Datagram — Datagram is an AI-driven, decentralized infrastructure platform operating as a DePIN baselayer. The company provides a live, scalable node network for launching custom DePIN networks and real-world decentralized applications, with cost savings over traditional cloud providers.
• Ooga Booga — Multichain Liquidity Aggregator
• Accountable — Accountable is the new standard for real-time financial verification. Prove assets and liabilities privately, powered by the Data Verification Network (DVN).

Portfolio highlights

• Meta Pool — The liquid staking layer for the onchain economy
• Amnis Finance — Stake APT on the best liquid staking protocol on Aptos to receive daily rewards with an attractive APR of 2%.
• Velvet Capital — Velvet Capital is a DeFi operating system that helps launch and manage on-chain funds and structured products. Velvet Capital offers its users a way to gain exposure to digital assets.

Portfolio highlights

• Pixelverse — We build Telegram games with memecoins communities. Play here: https://t.co/NH6j76YaZy Powered by $PIXFI
• Mavryk Dynamics — Real assets, Real people, Real solutions. Building a smarter, more secure future. Blockchain, Done Better. Building @MavrykNetwork & @MavenFinanceDAO.
• Swarm Network — Agentic infra for the future $TRUTH NEW: Build your Future agent teams in beta

Portfolio highlights

• 3VO — Bring Your Business On-chain. The easiest way to launch, grow, and own your brand with AI + Web3 tools - all in one simple, social platform.
• BlockJoy — Easily deploy and manage enterprise-scale blockchain nodes on any infrastructure for up to 80% less than the cloud.
• Nook — Nook is a personal knowledge base that helps capture, organize, and intelligently resurface what you need to know and do throughout your day. Get early access.

Portfolio highlights

• Rhuna — One white-label stack for payments, ticketing, access, and data across live entertainment.
• Entravel — Market leading hotel distribution API & room mapping. Agentic interface for AI agents. Turnkey hotel booking white labels for businesses.
• Cork Protocol — Cork's new DeFi primitive, Depeg Swaps allows investors to hedge and trade the risk of their pegged asset (LST/LRTs, Stablecoins, RWAs).

Portfolio highlights

• Latitude — Latitude is working on a global payments system that links stablecoin-based settlement with local currency payout systems.
• Splyce Finance — Liquidity for real assets. Yield for everyone else.
• Catchback Cards — Catchback Cards offers a platform for buying, selling, storing, and auctioning collectibles with pack opening and card-backed loan services.

Portfolio highlights

• BAYZ — NFT Gaming Startup | Esports & Content Community HUB | #PlayToEarn
• UNXD — UNXD is a curated NFT marketplace for the best of digital luxury and culture. Featuring NFTs from Dolce&Gabbana, Jacob & Co., and more.
• Mon Studios — An indie game development studio

Portfolio highlights

• Ooga Booga — Multichain Liquidity Aggregator
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• Nuva Labs — Tokenize, manage, and distribute RWAs on-chain. Compliant issuance, vault structuring, and DeFi distribution, built for asset issuers and managers.
• Prime Trust — Prime Trust powers innovation in the digital economy by providing fintech and digital asset innovators with financial infrastructure. Our API is customizable whether you're building a crypto exchange or expanding your business with digital assets.
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• MSafe — MSafe offers the most secure, decentralized, scalable Web3 non-custodial, multi-signature solution built on Move, ideal for dApp developers to use for treasury management, token management, smart contract development, blockchain protocol admin control, live on Aptos
• Polysights — Leverage intelligence to optimize your strategy on @Polymarket
• Turtle Club — Aggregated, diligenced, personalized onchain yield management.

Portfolio highlights

• Delabs Games — At Delabs Games, we want to create fun games that last a thousand years.
• PublicAI — PublicAI is a Web3 distributed AI training network that helps people to earn rewards by contributing data work.
• Power Protocol — The ecosystem for blockchain entertainment. Fueled by $POWER. Launch Partner: @Fableborne Power Up Your Play

Portfolio highlights

• Credora — The best online casino UAE platforms reviewed here. Explore the most trusted Arabic casino sites & read expert tips to help maximise your success.
• Sei Labs — Accelerating the Future The Fastest Layer 1 Blockchain
• Composable Corp — Composable Corp is a blockchain financial application developer.

Portfolio highlights

• Eywa — Founded in 2021, EYWA helps Web3 projects scale up by enabling them to operate, get listed, and traded on all connected blockchain networks with a single liquidity pool. Additionally, EYWA provides a truly decentralized data protocol for secure messaging.In partnership with Curve Finance, one of the largest decentralized exchanges, EYWA isintroducing a new paradigm of non-algorithmic cross-chain assets aimed at solving the problem of liquidity fragmentation. Their cross-chain protocol stands out as the most decentralized solution in the market.- Received 6 grants from biggest L1/L2 blockchain networks including NEAR Foundation, Aurora, Harmony One, Algorand, Boba Network, and others - Winning hackathons: Ethglobal Marketmake, Polygon’s BUIDL IT hackathon, Metis hackathon
• TG DAO 3.0 — TG DAO 3.0 is TG Ecosystem's launchpad for investing in conventional and crypto startups. All launchpad investors are considered to be co-owners and take part in the decision-making process for the launchpad functions. TG DAO 3.0 is a new crowdfunding blockchain launchpad on the TG Ecosystem that combines decentralized and centralizedinvesting, attracts mechanisms, and provides comprehensive support for startups.
• GoFungibles — GoFungibles is a cross-chain state-of-the-art NFT marketplace equipped with all the existing features of conventional NFT marketplaces but augmented with DeFi and gamified components.

Portfolio highlights

• DeHR — DeHR develops a talent marketplace with intuitive communication and onboarding tools to effectively connect recruiters and job candidates.
• Step Hero — Step Hero ecosystem combines NFT gaming and deFi. An engaging role-playing game with a fantasy theme, a cross-chained NFT marketplace, NFT collectibles, and the HERO token make up the ecosystem. Additionally, they offer a social network experience with a welcoming neighborhood.
• Himo World — Himo World is a match-3 deck building NFT. It features Free-to-Play, Create-to-Earn & Compete-to-Earn, including Rogue-like PvE & exciting PvP with Tournaments

Portfolio highlights

• Hito — Make crypto accessible and safe for all humans founder @mishabunte
• Kaiko — Kaiko provides real-time and historical cryptocurrency trade data, order books, and aggregated prices through a cryptocurrency API, downloadable CSV files, and a livestream WebSocket. We cover 100+ crypto exchanges and 35,000+ trading pairs for Bitcoin, Ethereum, and altcoins.
• Diameter Pay — Diameter Pay is a financial service company that provides financial inclusion, fintech, blockchain, and social entrepreneurship services.

Portfolio highlights

• StripChain — StripChain unifies all the blockchains
• Nest Wallet — A Wallet Built for Traders
• Switchboard — Switchboard allows builders to unlock the power of solana by creating high-performance data feeds from any API. They will bring data on-chain that will enable developers to unlock the future of decentralized applications. They enable the SOL community to push any form of data on-chain.

Portfolio highlights

• Fluxco — One spec in, competitive bids from 150+ global OEMs back in days. Procurement, leasing, service and warranty from one accountable partner.
• Sequen — Sequen is user behavior by design.
• FINN — At finn our mission is to make mobility fun and sustainable: We help everyone who loves driving their own car but refuses the struggle, commitment and intransparent costs associated with car ownership. We achieve this by offering all-inclusive, immediately available, monthly car-subscriptions. Best thing, yet: While you drive we plant trees asevery journey is CO2 compensated.

Portfolio highlights

• TBook — The first embedded RWA liquidity layer that brings institutional-grade tokenized yield into user-facing apps
• XStable — XStable is a decentralized trading platform that specializes in tangible assets.
• Splyce Finance — Liquidity for real assets. Yield for everyone else.

Portfolio highlights

• NEAR — NEAR is the open infrastructure powering the agent economy. NEAR unifies liquidity across 35+ chains, keeps execution and inference confidential, and scales to over 1 million TPS.
• LABS Group — Amazon138 Tidak peduli latar belakang, usia, atau pengalaman. Ada pintu yang selalu terbuka untukmu di sini. Dan di balik pintu itu, ada petualangan yang menunggumu.
• TG DAO 3.0 — TG DAO 3.0 is TG Ecosystem's launchpad for investing in conventional and crypto startups. All launchpad investors are considered to be co-owners and take part in the decision-making process for the launchpad functions. TG DAO 3.0 is a new crowdfunding blockchain launchpad on the TG Ecosystem that combines decentralized and centralizedinvesting, attracts mechanisms, and provides comprehensive support for startups.

Portfolio highlights

• ZHIYOU MEDIA — ZHIYOU MEDIA is a film and television company that specializes in film investment, production, IP incubation, and theater distribution.
• Splyce Finance — Liquidity for real assets. Yield for everyone else.

Portfolio highlights

• 3VO — Bring Your Business On-chain. The easiest way to launch, grow, and own your brand with AI + Web3 tools - all in one simple, social platform.

Portfolio highlights

• Splendor Labs — Splendor Labs is an AI platform which is built for clarity, control, and compounding progress.