Top 50 Web3 Startup Investors in Panama (July 2026)

Portfolio highlights

• Itheum — As we enter the web3 and metaverse era; Itheum unlocks data silos and generates new value for your data.
• OP_NET —
• Watch.fun —

Portfolio highlights

• The Arena — A next gen SocialFi app redefining how creators connect, engage, and monetize their content.
• Joystream — Joystream is a block chain-based, decentralized video platform.
• Sigma Computing — Sigma is the only BI analytics tool purpose-built for your cloud data warehouse. Uniquely scalable, with an experience you already know: the spreadsheet.

Portfolio highlights

• EBR Systems — EBR aims for outstanding treatment of cardiac rhythm diseases with an innovative leadless therapy.
• Cardiac Dimensions — Cardiac Dimensions, Inc. is a medical device company developing novel interventional tools for the treatment of heart failure and the related condition of mitral valve regurgitation. Our product, the Carillon® Mitral Contour System®, is a groundbreaking, non-surgical device developed to treat functional mitral valve regurgitation. Our system uses acatheter based approach to reshape the mitral valve and reduce mitral regurgitation.
• Ignite Tournaments — Ready to take your mobile games to the next level? Join Ignite Tournaments and compete in real money esports tournaments. Download our app now and win big!

Portfolio highlights

• GameFi.org —
• Ceramic Network — Ceramic Network is a provider of protocols for decentralized and composable data applications. The network decentralizes application databases, making data universally composable and reusable across applications. It consists of three core parts: a highly-scalable, decentralized infrastructure for data availability and consensus, a marketplace ofcommunity-created data models, and a suite of standard APIs for storing, updating, and retrieving data from those models.
• AI Pay with Crypto — AI Pay with Crypto is an AI-native financial infrastructure built for the emerging agent economy.APC enables autonomous AI agents to execute payments, settle transactions using programmable stablecoins, and connect directly to real-world merchant networks through QR codes, POS terminals, and other payment channels

Portfolio highlights

• SnakeLite — Snake Lite is a classic arcade snake game with a competitive edge and offers offline and online play. It is designed for smooth controls and fast performance.
• Sophon — Sophon brings the benefits of blockchain to everyday entertainment without the complexity. Discover games, social experiences, and applications that put users first, not technology.
• A.A.A C(H+A)RM — AAA C(H+A)RM (Autonomous AI Agents Launchpad & Layer3) is the first AI-first, agent-focused orchestration platform.

Portfolio highlights

• Wizzwoods — Wizzwoods is an open-world farming strategy game.
• Metatheory — Metatheory Inc. is an interactive technology and entertainment company building Web3 games, interactive content, social experiences, and other community-driven adventures. Metatheory’s mission is to inspire imagination by connecting people worldwide through immersive worlds built on cross-generational IP.
• Spaceport Technologies — Accelerating the growth of the next digital economy

Portfolio highlights

• Ignite Tournaments — Ready to take your mobile games to the next level? Join Ignite Tournaments and compete in real money esports tournaments. Download our app now and win big!

Portfolio highlights

• myco — myco is a content streaming super dApp that smoothly integrates AVOD and SVOD capabilities into a decentralized ecosystem.
• Metametaverse — Discover the future of virtual worlds with our metaverse platform. Explore, create and monetize your own metaverse experiences in a seamless and secure manner. Join the cosmic system of metaverses today.
• Ignite Tournaments — Ready to take your mobile games to the next level? Join Ignite Tournaments and compete in real money esports tournaments. Download our app now and win big!

Portfolio highlights

• 3VO — 3VO - The New Way We InternetIt’s the ultimate platform for creators and their communities, combining AI Agent Swarms, tokenized economies, and gamified engagement to transform how you connect with your audience.KEY FEATURES:AI Agents As CharactersCreate AI companions to automate content, manage pages, and interact with followers. Hireagents from a marketplace of unique AI personalities.Token Creation and TradingIssue and trade Meme Coins and Fan Tokens with real-world utility on ETH, BNB, and Base blockchains.Customizable PagesBuild unique pages using no-code templates to offer token-gated experiences, merch shops, social quests, events and more.Gamified EngagementUse 3VO Quests to reward followers with badges, cards, and tokens, boosting engagement and loyalty.Web3 InfrastructureEnjoy a built-in wallet with FIAT ramps, in-chat transfers, and a marketplace for seamless transactions and direct sales.4 products out: 3VO Web (https://app.3vo.me/)3VOgram - a TG mini-app (https://t.me/Official_3VOgram_bot)3VO Mobile (https://play.google.com/store/apps/details?id=me.threevo.client)3VO Mystery Box - precursor to 3VO Quest on 3VO Web (https://t.me/mysteryBox3voBot)PARTNERS & BACKERS:HyperGPT, Corum8 Ventures, GAINS Associates, IBC Group, Cookie3, Kima Network, Redbelly Network, SuperVerse, Verida Network, E-money Network, Skillful AI, BioFi Global (Finnovant), ChainGPT, Ultrade, SKALE, ICP and many more.

Portfolio highlights

• Nicegram —
• Hana Network — Hana Network is a software development company that develops and manages cryptocurrency and blockchain transactions.
• Cluster Protocol — Cluster Protocol is the co-ordination layer for AI agents, a carnot engine fueling the AI economy making sure the AI developers are monetized for their AI models and users get an unified seamless experience to build that next AI app/ agent within a virtual disposable environment facilitating the creation of modular, self-evolving AI agents.

Portfolio highlights

• AEON — AEON is a crypto payment framework designed for AI-driven and real-world transactions. It supports omni-chain payments across ecosystems like EVM, SVM, and TON, enabling seamless cross-chain usage. Its solutions include AI-powered payments, Web3 online and mobile payments, QR/contactless acceptance, and swap pay, all designed to simplifyadoption for users and merchants.
• AlchemyNFT — AlchemyNFT is a non-fungible token (NFT) service.
• Limited — Secure your treasury and scale your business globally with a truly self-custodial account that only you control. No banks. No middlemen.

Portfolio highlights

• GAMES.GG — Discover 1,500+ games with honest reviews, expert guides, and daily gaming news across PC, console, and mobile. Find your next favorite game on Steam, Epic Games, PlayStation, Xbox, and Nintendo.
• Sumer Money — Sumer Money is a cross-chain synthetic assets protocol that enables composable Defi across blockchains.
• SYNTRA — Syntra is an AI-driven trading infrastructure company focused on disciplined execution, real-time risk management, and transparent market operations in digital asset markets. The company builds systems that monitor market structure, volatility, liquidity, and correlation dynamics, enabling automated decision-making with strict risk controls.Syntra’s infrastructure is designed to prioritize execution quality, capital preservation, and operational transparency over short-term performance optimization.Syntra operates a live execution environment where all system actions are observable in real time, providing an open view into how the trading system behaves across different market conditions. The platform is infrastructure-first, emphasizing robustness, scalability, and controlled growth rather than aggressive user acquisition. The company is currently focused on expanding its execution stack, data pipelines, and risk management framework to support broader market coverage and institutional-grade reliability.

Portfolio highlights

• Himedi — Himedi is an information technology company that provides hospital reservation service.
• Una Brands — Ready to sell your e-commerce business? We'll make the process fair, fast, and fuss-free. Continue to profit as we grow your brand.
• Boostsecurity.io — Boostsecurity.io is a computer software company that assists software developers to discover cybersecurity-related issues. It was founded in 2020 and its headquarters is located in Montreal, Quebec.

Portfolio highlights

• D3 — D3 - DNS Domains for Web3
• Share — Share XYZ is an information technology service provider
• Forta Protocol000 — Powered by the most advanced AI detection model, Forta Firewall integrates with protocols and rollups to prevent over 99% of hacks.

Portfolio highlights

• Enso Finance — Social trading redefined. Create Alpha strategies, share and compete with your friends, community or DAO. Discover and create open defi strategies page.
• Mevvy Network — Mevvy Network enables seamless MEV on any chain, reducing the barrier of entry for searchers.
• Tools For Humanity — Tools for Humanity is a technology company building for humans in the age of AI.

Portfolio highlights

• Depinsim — DepinSim is a blockchain-based eSIM platform that lets users access global mobile data and earn rewards.
• Superset —
• ZenChain — ZenChain is a Layer-1 blockchain focused on secure, EVM-compatible smart contracts and cross-chain interoperability.

Portfolio highlights

• Portal to Bitcoin — The only custody-less interoperability protocol for Bitcoin. Swap native BTC, Ordinals, Runes with L2s and L1s
• Acta Finance — Acta Finance develops a complete DeFi ecosystem, EVM compatible, able to deploy and integrate EVM compatible networks.
• Monarch Wallet — As part of this journey, we will discontinue our wallet services effective July 1, 2024.

Portfolio highlights

• Polygen — Polygen provides a breath of fresh air in the world of blockchain launchpads. Current solutions all foster innovation on a specific blockchain, but they also look and operate the same. Fueling innovation in this industry requires the removal of all intermediaries and gatekeepers. Additionally, there is a need for more transparency, automatedprocesses, and post-launch support.
• Planet Sandbox — Planet Sandbox is the third-person NFT sandbox game that powers players with limitless building tools to customize their own worlds and design game modes. It allows players to build and own arenas to fight other players in different game modes using their own NFT weapons and accessories.
• Ignite Tournaments — Ready to take your mobile games to the next level? Join Ignite Tournaments and compete in real money esports tournaments. Download our app now and win big!

Portfolio highlights

• VAST.app —
• Mavryk Dynamics — Mavryk Dynamics simplifies trading real-world assets (RWA) and using decentralized finance (DeFi).
• Swarm Network — Swarm Network is a decentralized network for owning, controlling, and monetizing AI agents.

Portfolio highlights

• Fjord Foundry — Fjord enables teams the ability to openly and fairly generate liquidity by connecting inspired projects with passionate supporters via Liquidity Bootstrapping Pools.
• Zaros Finance — Zaros is a protocol that provides efficient liquidity, boosts staking rewards from LSTs, and aims to become the preferred liquidity hub for on-chain derivatives.
• Layer Social Labs — A home for global companionship and endless entertainment. Post More, Play More, Earn More.

Portfolio highlights

• Kapkap — Kapkap is a web3 platform that uses AI for attention based value distribution in gaming.
• SuperIntent —
• Inference Labs — AI hyperscale on decentralized networks - We provide certainty for on-chain AI

Portfolio highlights

• BullPerks — BullPerks is a community of like-minded individuals who want to leverage their power and invest together in the best projects on equal terms with VCs.
• Hashflow — Tight spreads. Zero slippage. MEV-resistant.
• Joystream — Joystream is a block chain-based, decentralized video platform.

Portfolio highlights

• Nuva Labs — Tokenize, manage, and distribute RWAs on-chain. Compliant issuance, vault structuring, and DeFi distribution, built for asset issuers and managers.
• Prime Trust — Prime Trust powers innovation in the digital economy by providing fintech and digital asset innovators with financial infrastructure. Our API is customizable whether you're building a crypto exchange or expanding your business with digital assets.
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• Capx — Capx's mission is to accelerate the flow of capital through the private markets, thereby enhancing global capital allocation. With secondary market and enterprise solutions, Capx combines high-quality collections of opportunities with efficient access for institutions and individual investors.
• Noodles Finance — The no-brainer trading platform for Sui.
• YOAKE Entertainment — YOAKE Entertainment is a music studio that specializes in the planning, production, and development of entertainment content.

Portfolio highlights

• AHAlife — AHAlife is a fashion-based e-commerce platform connecting designers, brands, and publishers to individuals. The company's mission is to connect the best the world has to offer with discerning individuals from around the world. It is a discovery shopping destination for curated lifestyle products that span design, technology, fashion, media,food, beauty, and travel. Its platform sits at the intersection of content, commerce, and curation.
• OpenGamma — Join the leading firms using OpenGamma's derivatives margin analytics to improve their capital efficiency.
• Lolly Wolly Doodle — Lolly Wolly Doodle is passionate about providing families across the country with beautiful, high-quality and affordable apparel and accessories. It believes deeply in the importance of American manufacturing and are proud to manufacture over 50% of their items entirely in their Lexington factory.

Portfolio highlights

• GENCY AI — Gency AI is a Web3 platform for privacy-focused, verifiable digital ads using encrypted data and proof-based tracking.
• Voyage — Voyage AI is an AI infrastructure project building the first GEOFi network to make AI-generated content citable.
• Interstate — Interstate is an Ethereum pre-confirmation protocol. It aims to make Ethereum transactions near-instant and allow applications to self-order while maintaining full composability with L1.

Portfolio highlights

• TITAN — Titan provides users with the best swap price by searching through Solana’s on-chain liquidity through trusted sources. It then deploys revolutionary routing algorithms based on cutting-edge mathematics to determine the best price a user can get when trading any token.
• assisterr — Enterprise-grade Specialized AI Agents for Business. Assisterr AI Lab builds domain-specific SLMs and AI Agents. Agent Tokenization as a Service (ATaaS) for AI startups.
• Splyce Finance — dETF protocol. Permissionless, on-chain index- and yield ETFs.

Portfolio highlights

• TBook — TBook is a full-stack, chain-agnostic infrastructure layer designed for the digital workforce.
• Splyce Finance — dETF protocol. Permissionless, on-chain index- and yield ETFs.
• Noodles Finance — The no-brainer trading platform for Sui.

Portfolio highlights

• Hemi Labs — Hemi (https://hemi.xyz) is a modular protocol that integrates Bitcoin and Ethereum to amplify and extend the core capabilities of the two leading blockchain networks. This offers a novel perspective on blockchain interoperability and scaling by approaching Bitcoin and Ethereum as components of a single supernetwork. The result providessecurity that exceeds that of Bitcoin (“superfinality”) and new levels of blockchain programmability, portability, and potential. Hemi was co-founded by Jeff Garzik (former Bitcoin core developer) and Max Sanchez (inventor of the Proof-of-Proof consensus protocol), and is surrounded by a team of renowned blockchain engineers, strategic partners and investors.
• Sapien — Sapien offers Data Labelling Services with RLHF to fine-tune your LLMs potential. Improve model performance with better data to improve outcomes. Consult us now!
• Movement Labs — Movement Labs is on a mission to create a global community of Move Builders, working together to improve decentralized network user experience.

Portfolio highlights

• Nexio — Nexio is a bitcoin scaling solution platform that helps to improve cryptocurrency's scalability by using parallelizing Bitcoin rollouts.
• Turtle Club — Turtle aligns incentives between protocols and LPs to offer the best curated incentives in DeFi.
• Neutral Trade — Neutral Trade, an on-chain multi-strategy hedge fund platform, offers innovative delta-neutral trading and liquidity provisioning strategies to deliver consistent, risk-adjusted returns.

Portfolio highlights

• 375ai — 375ai is an edge data intelligence network on Solana that provides advanced real-time data collection and analysis to power a smarter, more connected world.
• XTAO — XTAO's objective is to accelerate the development and use of decentralized AI.
• Spaceport Technologies — Accelerating the growth of the next digital economy

Portfolio highlights

• Nudos — B2B platform that enables companies to manage the equipping of hybrid workers distributed over the world. From the Onboarding (devices procurement anywhere) to the offboarding (recovery and storaged of devices), and everything in between. The company was founded in 2022 and headquartered in Mexico City , Mexico.
• Ebombo — Somos la empresa de organizacion de eventos corporativos en Mexico y Peru. Conferencias, team building, lanzamientos y mas. Cotiza tu evento hoy!
• Lineup — Lineup is a lead scoring SaaS for growth teams.

Portfolio highlights

• Delabs Games — At Delabs Games, we want to create fun games that last a thousand years.
• PublicAI — PublicAI is a Web3 distributed AI training network that helps people to earn rewards by contributing data work.
• Power Protocol — Power Protocol is an infrastructure layer that drives the single, cohesive blockchain entertainment ecosystem.

Portfolio highlights

• Splyce Finance — dETF protocol. Permissionless, on-chain index- and yield ETFs.

Portfolio highlights

• Hitcard — Hitcard is a trendy card culture brand that uses technology to upgrade card-like consumer products.
• Stems Labs — community and platform for collaborative creativity
• MetaverseGo — MetaverseGo is a web 3.0 app that offers easy access to Play-and-Earn Games, Guilds, NFTs, and Decentralized Applications allowing users to own assets, connect with industry players, and use their earnings across multiple payment platforms.

Portfolio highlights

• Latitude — Latitude is working on a global payments system that links stablecoin-based settlement with local currency payout systems.
• Solmate — Brera Holdings PLC is an Irish holding company focused on growing social impact football (American soccer) through the development of a global portfolio of emerging football clubs with increased opportunities to win tournament prizes, gain sponsorships, and provide other professional football and related consulting services. The Company intends tobuild on the legacy and brand of Brera FC, the Company's first football club acquisition. Brera FC, also known as "The Third Team of Milan".
• Splyce Finance — dETF protocol. Permissionless, on-chain index- and yield ETFs.

Portfolio highlights

• Play AI — The Orchestration Layer for Crypto x AI
• Metagood — Tokenization as a Service for Modern Capital Markets
• VOYA Games —

Portfolio highlights

• NEAR — NEAR is the unified commerce layer for unlocking asset liquidity and empowering agents to autonomously transact.
• TG DAO 3.0 — TG DAO 3.0 is TG Ecosystem's launchpad for investing in conventional and crypto startups. All launchpad investors are considered to be co-owners and take part in the decision-making process for the launchpad functions. TG DAO 3.0 is a new crowdfunding blockchain launchpad on the TG Ecosystem that combines decentralized and centralizedinvesting, attracts mechanisms, and provides comprehensive support for startups.
• Shiden Network — Shiden Network is a multi-chain decentralized application layer on Kusama Network. Kusama Relaychain does not support smart contract functionality by design - Kusama Network needs a smart contract layer. This is where Shiden Network comes in. Shiden supports Ethereum Virtual Machine, WebAssembly, and Layer2 solutions from day one. The platform supports various applications like DeFi, NFTs and more.

Portfolio highlights

• Datagram — Datagram is an AI-driven, decentralized infrastructure platform operating as a DePIN baselayer. The company provides a live, scalable node network for launching custom DePIN networks and real-world decentralized applications, with cost savings over traditional cloud providers.
• Ooga Booga — Multichain Liquidity Aggregator
• Accountable — Accountable is the new standard for real-time financial verification. Prove assets and liabilities privately, powered by the Data Verification Network (DVN).

Portfolio highlights

• MSafe — MSafe offers the most secure, decentralized, scalable Web3 non-custodial, multi-signature solution built on Move, ideal for dApp developers to use for treasury management, token management, smart contract development, blockchain protocol admin control, live on Aptos
• Turtle Club — Turtle aligns incentives between protocols and LPs to offer the best curated incentives in DeFi.
• Momentum — Momentum is a move central liquidity engine with multi-sig treasury management, token vesting, and liquidity provisioning.

Portfolio highlights

• Ooga Booga — Multichain Liquidity Aggregator
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• Eywa — Founded in 2021, EYWA helps Web3 projects scale up by enabling them to operate, get listed, and traded on all connected blockchain networks with a single liquidity pool. Additionally, EYWA provides a truly decentralized data protocol for secure messaging.In partnership with Curve Finance, one of the largest decentralized exchanges, EYWA isintroducing a new paradigm of non-algorithmic cross-chain assets aimed at solving the problem of liquidity fragmentation. Their cross-chain protocol stands out as the most decentralized solution in the market.- Received 6 grants from biggest L1/L2 blockchain networks including NEAR Foundation, Aurora, Harmony One, Algorand, Boba Network, and others - Winning hackathons: Ethglobal Marketmake, Polygon’s BUIDL IT hackathon, Metis hackathon
• TG DAO 3.0 — TG DAO 3.0 is TG Ecosystem's launchpad for investing in conventional and crypto startups. All launchpad investors are considered to be co-owners and take part in the decision-making process for the launchpad functions. TG DAO 3.0 is a new crowdfunding blockchain launchpad on the TG Ecosystem that combines decentralized and centralizedinvesting, attracts mechanisms, and provides comprehensive support for startups.
• GoFungibles — GoFungibles is a cross-chain state-of-the-art NFT marketplace equipped with all the existing features of conventional NFT marketplaces but augmented with DeFi and gamified components.

Portfolio highlights

• Splendor Labs — Splendor Labs is an AI platform which is built for clarity, control, and compounding progress.

Portfolio highlights

• True Labs — True Labs is an AI-driven, decentralized exchange company.

Portfolio highlights

• Cashlink — The financial technology start-up (Fintech) Cashlink has developed one of Europe's leading Tokenization-as-a-Service solutions. A modular, technological infrastructure enables the legally compliant issuance and management of digital securities for banks and investment platforms as an all-in-one solution. Compared to a traditional security,tokenized financial instruments create significant cost reductions and opportunities for opening up new markets and products, giving issuing companies, banks and investment platforms a sustainable competitive advantage. Renowned companies such as the Frankfurt securities specialist Bankhaus Scheich are already successfully using the Cashlink solution today. Cashlink is an official partner of Deutsche Börse Venture Network and completes its comprehensive range of digital securities by cooperating with experienced and specialized partners such as the globally operating law firm Ashurst. Renowned European investment companies such as the listed FinLab AG and the seed + speed-VC of the Maschmeyer Group are invested in the Fintech. As a founding member of the European forum "International Association for Trusted Blockchain Applications" (INATBA), the Hesse regional group of the Blockchain Bundesverband and the International Token Standardization Association (ITSA), Cashlink is already shaping tomorrow's capital market today.
• Jia — Small businesses drive the economy. They deserve to own a piece of it. Jia gives entrepreneurs anywhere in the world power to control their financial destiny. We provide blockchain-based financing to businesses in emerging markets and reward them with ownership, enabling them to create wealth and prosperity for themselves and their communities.
• Splyce Finance — dETF protocol. Permissionless, on-chain index- and yield ETFs.

Portfolio highlights

• TipLink — TipLink helps send crypto with a link. Someone with crypto can create a account and send that link to anyone over any platform. It’s like buying a gift card, connect the client's crypto wallet of choice and create a account by depositing how much they want to send.
• Momentum — Momentum is a move central liquidity engine with multi-sig treasury management, token vesting, and liquidity provisioning.
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• Mon Studios — An indie game development studio
• Ignite Tournaments — Ready to take your mobile games to the next level? Join Ignite Tournaments and compete in real money esports tournaments. Download our app now and win big!

Portfolio highlights

• Zabo — Zabo is an API for connecting to any crypto exchange, wallet, protocol or account. Sign up for access to free API keys at Zabo.com
• Joystream — Joystream is a block chain-based, decentralized video platform.
• Ceramic Network — Ceramic Network is a provider of protocols for decentralized and composable data applications. The network decentralizes application databases, making data universally composable and reusable across applications. It consists of three core parts: a highly-scalable, decentralized infrastructure for data availability and consensus, a marketplace ofcommunity-created data models, and a suite of standard APIs for storing, updating, and retrieving data from those models.

Portfolio highlights

• Composable Corp — Composable Corp is a blockchain financial application developer.
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• StripChain — Stripchain is an intent-based interoperability standard that enables chain abstraction.
• Nest Wallet — A Wallet Built for Traders
• Switchboard — Switchboard allows builders to unlock the power of solana by creating high-performance data feeds from any API. They will bring data on-chain that will enable developers to unlock the future of decentralized applications. They enable the SOL community to push any form of data on-chain.