Top 50 Software VC Funds & Investors in Panama (August 2026)

Portfolio highlights

• Rivalz Network — Join the connectivity infrastructure between AI Agents, DeFAI and Markets.
• The Arena — A next gen SocialFi app redefining how creators connect, engage, and monetize their content.
• Sigma Computing — Sigma is the only BI analytics tool purpose-built for your cloud data warehouse. Uniquely scalable, with an experience you already know: the spreadsheet.

Portfolio highlights

• EBR Systems — EBR aims for outstanding treatment of cardiac rhythm diseases with an innovative leadless therapy.
• Cardiac Dimensions — Cardiac Dimensions, Inc. is a medical device company developing novel interventional tools for the treatment of heart failure and the related condition of mitral valve regurgitation. Our product, the Carillon® Mitral Contour System®, is a groundbreaking, non-surgical device developed to treat functional mitral valve regurgitation. Our system uses acatheter based approach to reshape the mitral valve and reduce mitral regurgitation.
• Ignite Tournaments — Empower content creators to launch custom quest lines, track fan engagement, and manage premium subscription communities.

Portfolio highlights

• OpenPad AI — OpenPad - The 1st AI Decentralized Launchpad
• Stabble — stabble is a protocol revolutionizing liquidity pools by introducing protocol-managed and arbitrage pools. This allows stabble to tackle critical inefficiencies prevalent within Solana's decentralized exchanges.
• AI Cross Matrix — AI Cross Matrix is a DeFi platform that makes the crypto economy simple by streamlining the exchange process with useful solutions.

Portfolio highlights

• OP_NET — OPNET is a Bitcoin Layer 1 metaprotocol that enables smart contracts to function directly on the Bitcoin blockchain, without the use of sidechains or Layer 2 solutions.
• Watch.fun — Luxury watch drops. Win a Rolex for as little as $7, drops weekly. Certified by Wristcheck. Backed by @TheSpartanGroup @SolanaVentures @BigBrainVC and more...
• Space — The first leveraged prediction market on @solana

Portfolio highlights

• PERL.eco — The Planetary Ecosystem Registration Ledger will be a dedicated blockchain for real-world ecological assets through tokenizing carbon credits and biodiversity, NFTs and decentralised (DeFi) rewards.
• A-World — Welcome to Animal World, a battle game based on #BNBCHAIN's super metaverse card tower defense. By setting up a hero tower to destroy monsters.
• NeuronX — The First AI-Driven Lending Protocol on @dfinity

Portfolio highlights

• Capx — Capx's mission is to accelerate the flow of capital through the private markets, thereby enhancing global capital allocation. With secondary market and enterprise solutions, Capx combines high-quality collections of opportunities with efficient access for institutions and individual investors.
• DeepSafe — The world's first Cryptographic Random AI Verification Network for trustless verification of any on-chain and off-chain messages.
• aPriori — aPriori is a monad-native MEV infrastructure and liquid staking mechanism developed for parallel executions.

Portfolio highlights

• Meta Pool — Meta Pool is a multi-chain, liquid staking-based ecosystem with Vote-to-Earn DAO governance.
• Amnis Finance — Stake APT on the best liquid staking protocol on Aptos to receive daily rewards with an attractive APR of 2%.
• Velvet Capital — Trade any crypto onchain - spot and perpetuals across 7 chains with AI-powered routing. Non-custodial DeFi trading terminal + AI trading bot. 100K+ traders.

Portfolio highlights

• Wizzwoods — 1st pixel farm game integrates interchain capabilities with a SocialFi twist.
• SuperIntent — SuperIntent is a cryptocurrency AI app that streamlines on-chain earning tactics. Developed on a multi-agent framework with abundant yield sources.
• SuperGaming — At SuperGaming, we are putting India on the global gaming map.

Portfolio highlights

• AEON — Powering #agenticeconomy #x402 | AEON is settlement layer bridging autonomous AI interactions (A2A & A2M) with real-world value flows. Backed by @yzilabs $AEON
• KOR Protocol — KOR Protocol is a decentralized intellectual property (IP) infrastructure designed to empower creators, protect rights, and enable seamless collaboration and monetization of IP assets across various industries, including music, film, TV, gaming, and art. Backed by notable entities like Animoca Brands, Republic, Niantic, Sfermion, Solana, andprominent creators such as Black Mirror, Disclosure, deadmau5, and Richie Hawtin, KOR leverages blockchain, AI, and DeFi to offer a transparent, efficient, and scalable environment for IP expansion.
• Limited — Secure your treasury and scale your business globally with a truly self-custodial account that only you control. No banks. No middlemen.

Portfolio highlights

• DHL — DHL is a division of the German logistics company Deutsche Post DHL that provides international express mail services. Deutsche Post is a large-scale logistics company operating around the world. DHL provides world market services both in sea and air mail.DHL was primarily interested in offshore and inter-continental deliveries, but the successof FedEx prompted its own intra-U.S. expansion starting in 1983. DHL aggressively expanded to countries that could not be served by any other delivery service, including the Soviet Union, Eastern Bloc, Iraq, Iran, China, Vietnam, and North Korea.Deutsche Post then effectively absorbed DHL into its Express division, while expanding the use of the DHL brand to other Deutsche Post divisions, business units and subsidiaries.Originally founded in 1969 to deliver documents between San Francisco and Honolulu, the company expanded its service throughout the world by the late 1970s. DHL was founded in 1969 and is based in Bonn.
• ShoeFy — ShoeFy is a decentralized project that combines nonfungible tokens (NFTs) and fungible tokens (FTs) on one platform to add new utility layers to NFTs.

Portfolio highlights

• myco — myco is a content streaming super dApp that smoothly integrates AVOD and SVOD capabilities into a decentralized ecosystem.
• Metametaverse — Discover the future of virtual worlds with our metaverse platform. Explore, create and monetize your own metaverse experiences in a seamless and secure manner. Join the cosmic system of metaverses today.
• Ignite Tournaments — Empower content creators to launch custom quest lines, track fan engagement, and manage premium subscription communities.

Portfolio highlights

• SQR3D — Transform your idea into 3D assets at scale. Smart Contract Automation for 3D Designs with SQR3D.
• Reitio Protocol — We’re creating an effortless way for everyone to create custom metaverse assets visually via an intuitive and codeless templates-based design toolkit, introducing reitio protocol.
• Genesis Shards — Crafting a whole new suite of NFT powered products across multiple blockchains

Portfolio highlights

• SnakeLite — 10-min prediction markets on Hyperliquid whale positions, BTC and ETH. Predict up or down. Settle onchain. From the 100M+ download SnakeLite game.
• Sophon — Soph(+) is a tech studio building novel consumer experiences in crypto and ai. we build, own, and ship our own products, starting with pyre.
• A.A.A C(H+A)RM — AAA C(H+A)RM (Autonomous AI Agents Launchpad & Layer3) is the first AI-first, agent-focused orchestration platform.

Portfolio highlights

• MSafe — MSafe offers the most secure, decentralized, scalable Web3 non-custodial, multi-signature solution built on Move, ideal for dApp developers to use for treasury management, token management, smart contract development, blockchain protocol admin control, live on Aptos
• Polysights — Leverage intelligence to optimize your strategy on @Polymarket
• Turtle Club — Aggregated, diligenced, personalized onchain yield management.

Portfolio highlights

• Alphea — ALPHEA is an AI-native execution OS that awakens intelligence across every surface.
• Dow Protocol — An E-Commerce Financing RWA Platform on @BNBCHAIN, facilitating assets trusted by the world's largest banks. Lead invested by @mhventures @Maple_block
• Fortune Protocol — Fortune Protocol brings the age- old tradition of fortune cookies to the modern prediction market.

Portfolio highlights

• Vangrid — Vangrid operates as a decentralized physical infrastructure network.
• Dow Protocol — An E-Commerce Financing RWA Platform on @BNBCHAIN, facilitating assets trusted by the world's largest banks. Lead invested by @mhventures @Maple_block
• Ceramic Network — We've joined @textileio to build the first open intelligence network for AI agents. Follow us there.

Portfolio highlights

• GAMES.GG — Discover 1,500+ games with honest reviews, expert guides, and daily gaming news across PC, console, and mobile. Find your next favorite game on Steam, Epic Games, PlayStation, Xbox, and Nintendo.
• Sumer Money — Sumer Money is a cross-chain synthetic assets protocol that enables composable Defi across blockchains.
• SYNTRA — Live AI trading system. Real-time execution, risk-managed positions, public trade feed. Signals, performance, transparency.

Portfolio highlights

• ShoeFy — ShoeFy is a decentralized project that combines nonfungible tokens (NFTs) and fungible tokens (FTs) on one platform to add new utility layers to NFTs.
• CryptoTanks — CryptoTanks is a play-to-earn platform where every NFT is usable in a gamified DeFi ecosystem. With the tanks, the player earns money and plays games partially owned and operated by their players. Earn tank tokens by playing and use them to decide the future of the game. They offer design and prizes that come with gamified yield farming.
• Astra Guild Ventures — Astra Guild Ventures is one of the world's play-to-earn gaming guilds. Astra Guild Ventures is bridging the gap between players and investors in order to capitalize on the growth of non-traditional games.

Portfolio highlights

• Himedi — Himedi is an information technology company that provides hospital reservation service.
• FINN — At finn our mission is to make mobility fun and sustainable: We help everyone who loves driving their own car but refuses the struggle, commitment and intransparent costs associated with car ownership. We achieve this by offering all-inclusive, immediately available, monthly car-subscriptions. Best thing, yet: While you drive we plant trees asevery journey is CO2 compensated.
• Una Brands — Ready to sell your e-commerce business? We'll make the process fair, fast, and fuss-free. Continue to profit as we grow your brand.

Portfolio highlights

• 5ire — 5ire is a blockchain network that brings sustainability, technology, and Innovation to build the 5th industrial revolution (5IR). The mission of the 5ire ecosystem is to embed the for-benefit paradigm at the heart of the blockchain, highly incentivize practices that align with the United Nations Sustainable Development Goals (SDGs), facilitate thetransition from the 4IR to 5IR and accelerate the implementation of the UN 2030 Agenda for Sustainable Development. The company's primary offering is 5ireChain, a layer one, sustainability-driven 5th generation blockchain that ensures adherence to the philosophy of 5IR, creating a net positive impact on the planet and serving humanity.
• Polygen — Polygen provides a breath of fresh air in the world of blockchain launchpads. Current solutions all foster innovation on a specific blockchain, but they also look and operate the same. Fueling innovation in this industry requires the removal of all intermediaries and gatekeepers. Additionally, there is a need for more transparency, automatedprocesses, and post-launch support.
• Ignite Tournaments — Empower content creators to launch custom quest lines, track fan engagement, and manage premium subscription communities.

Portfolio highlights

• TipLink — TipLink helps send crypto with a link. Someone with crypto can create a account and send that link to anyone over any platform. It’s like buying a gift card, connect the client's crypto wallet of choice and create a account by depositing how much they want to send.
• Momentum — Momentum is a move central liquidity engine with multi-sig treasury management, token vesting, and liquidity provisioning.
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• GAMES.GG — Discover 1,500+ games with honest reviews, expert guides, and daily gaming news across PC, console, and mobile. Find your next favorite game on Steam, Epic Games, PlayStation, Xbox, and Nintendo.
• Flappy Bird — Flappy Bird Foundation is to uphold the Flappy Bird intellectual property and further the Flappy Bird heritage. The Foundation accurately restores our vintage and nostalgic gameplay while adding new features to give back to the worldwide fan base that started the craze.
• Community Labs — Community Labs is a software development company and venture studio focused on accelerating developer tools, use cases, and adoption of Arweave and AO.

Portfolio highlights

• BAYZ — NFT Gaming Startup | Esports & Content Community HUB | #PlayToEarn
• UNXD — UNXD is a curated NFT marketplace for the best of digital luxury and culture. Featuring NFTs from Dolce&Gabbana, Jacob & Co., and more.
• Mon Studios — An indie game development studio

Portfolio highlights

• Starbots — Starbots is Solana's first-ever battle NFT game.
• Linear — Linear allows the user to manage software development and track bugs. Built for speed and efficiency.The founders started Linear from their own frustrations building software projects in successful high-growth companies like Airbnb, Coinbase and Uber. The founders wanted to create the tools that focus us and its team in making progress, not getin the way. Tools that are fast and efficient. Speed and performance were the main things Linear focuses on early on and keep focusing on that.
• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.

Portfolio highlights

• Kuri — Kuri is a healthtech company that uses AI for revenue cycle management services at hospitals, laboratories, and clinics.
• Seeri — Easy, affordable, and comprehensive: personalized catalog, sales tracking, credit, inventory management, and more, all in one place.
• 4.screen — The Driver Interaction Platform. Connect with drivers in real-time to deliver personalized and targeted campaigns.

Portfolio highlights

• Pixelverse — We build Telegram games with memecoins communities. Play here: https://t.co/NH6j76YaZy Powered by $PIXFI
• Mavryk Dynamics — Real assets, Real people, Real solutions. Building a smarter, more secure future. Blockchain, Done Better. Building @MavrykNetwork & @MavenFinanceDAO.
• Swarm Network — Agentic infra for the future $TRUTH NEW: Secrets for agents at runtime tryvvault . xyz

Portfolio highlights

• CESS — CESS is a blockchain-based, decentralized Layer-1 infrastructure that integrates distributed storage, a high-speed content delivery network.
• Dmail — Dmail Network is a decentralized mailbox that provides a safe and private environment for users' communication, storage, tokens, and NFTs. The company was founded by Mittal S. and Lucas L. in 2021.
• Cumulus Encrypted Storage System (CESS) — CESS revolutionizes AI, DeSci, RWA, Enterprise, and more with secure, transparent, and traceable data solutions. Delivering AI computing and data infrastructure, CESS enables data privacy and sovereignty with a focus on AI Agent applications and frameworks.

Portfolio highlights

• Revomon — CA: 0xaab09b5cd1694d12c8c980306f5e2f5d65b00e1c Join the community here https://t.co/AkzLXfXr8s Backed by @Immutable
• MonoPolist — MonoPolist offers a cross-platform gaming universe with NFT features and rewards players with MONO and MOB tokens.
• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.

Portfolio highlights

• Ankr — Get faster, more reliable multi-chain development tools
• WOO Network — Discover WOO's ecosystem of centralized and decentralized apps to seize every opportunity in crypto.
• AllianceBlock — AllianceBlock is now Nexera. Follow us on @Nexera_Official

Portfolio highlights

• Momint — Momint is the Web3 investment platform of the future. The safest and easiest to use NFT marketplace in the world. Discover the real-world potential of NFTs.
• Rabbit — At Rabbit, we plan to change how the world shops.Retail has witnessed one revolution before with the introduction of E-Commerce that changed how customers order stuff and the second revolution is here! We are proud to be among the pioneers, a handful of global entrepreneurs that are leading and shaping the retail's second revolutionWe arefunded by amazing VCs that are helping us build the next big thingYou feel it is vague? that's intended as we are still building in stealth. but trust us, it is COOL!
• Beeline Learn — Enjoy Learning Effectively. Beta version is now LIVE!

Portfolio highlights

• 375ai — 375ai is an edge data intelligence network on Solana that provides advanced real-time data collection and analysis to power a smarter, more connected world.
• Beam — Beam enables you to send and receive payments with speed, efficiency, and security like never before.
• XTAO — Publicly traded Bittensor company. Bridging TradFi and TAO. (TSXV: XTAO.U | OTC: XTAIF)

Portfolio highlights

• Spicenet — Spicenet enables universal access to the top DeFi venues across all networks, creating better financial outcomes for all.
• Real Finance — Real Finance is driven by the mission to revolutionize the financial landscape by integrating real-world assets with blockchain technology, creating a more transparent, secure, and efficient ecosystem that bridges traditional finance with decentralized innovation, enhances asset liquidity, and unlocks new opportunities for global investors.
• WorkQuest — About WorkQuest WorkQuest is a decentralized employment and workforce automation protocol enabling employers and workers to collaborate through smart contracts, stablecoin payments, AI matching engines, and on-chain reputation scoring. The platform transforms global employment into a transparent, verifiable, and borderless digital labor economy.

Portfolio highlights

• ZAP — ZAP offers a reputation-based token distribution protocol that supports fair rewards for user contributions within the Blast ecosystem. It enables users to participate in various projects through missions and seamless investment options. Additionally, ZAP is expanding its services to other blockchains and developing tools to simplify access toventure-capital-backed projects.
• Galaxis — Galaxis maintains an engagement platform that aims to transform and strengthen the relationship between creators and their communities. The company's platform assists creators by injecting simple NFTs with unique utilities that can expand and alter.
• Velvet Capital — Trade any crypto onchain - spot and perpetuals across 7 chains with AI-powered routing. Non-custodial DeFi trading terminal + AI trading bot. 100K+ traders.

Portfolio highlights

• OX.FUN — Trade Bitcoin, Ethereum and trending altcoin derivatives on the most FUN exchange around. Join OX.FUN today and earn up to 200% yield. Moo.
• AINN Layer2 — AINN Layer2 is a decentralized Bitcoin Layer2 network development.It promotes large-scale AI applications
• Sanctum — Stake SOL and earn optimized LST returns from JupSOL, bbSOL, and more, and launch your own custom LST and Solana validator.

Portfolio highlights

• Depinsim — The Free Internet Protocol. Earn free mobile data at https://t.co/xm18x6oDwx
• Superset — The Unified Execution Layer for stablecoins, tokenized deposits, and onchain FX. One shared liquidity market, accessible across all chains.
• ZenChain — The first decentalised Bitcoin EVM L1 bringing smart contracts, composability, and true cross-chain liquidity to BTC.

Portfolio highlights

• Demole — Demole is a play to earn NFT gamification platform.
• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.
• Radom — A Decentralised Network for Coordination of Cloud Applications and Connected Assets

Portfolio highlights

• Hawksight — Hawksight provides a protocol that optimizes yield on Solana DeFi. It offers a concentrated liquidity yield optimizer with self-custodial and automated market-making strategies. Users can earn optimized yields from Solana's top DeFi protocols and manage their positions in one platform. Hawksight aims to build Solana's largestdecentralized finance yield aggregator protocol.
• Hybrid — Hybrid is a fintech company that offers a decentralized central AI tool with Web3's ecosystem of AI experts, agents, and data.
• Liquorice — We're thrilled to announce our $1.2M pre-seed round, led by @greenfield_cap and with participation from @l2iterative, @polymorphiccap, @HoradrimCapital, and @HASHCIB. Angel investors include founders from @1inch.

Portfolio highlights

• StripChain — StripChain unifies all the blockchains
• Nest Wallet — A Wallet Built for Traders
• Switchboard — Switchboard allows builders to unlock the power of solana by creating high-performance data feeds from any API. They will bring data on-chain that will enable developers to unlock the future of decentralized applications. They enable the SOL community to push any form of data on-chain.

Portfolio highlights

• XOCIETY — XOCIETY, a POP Shooter with RPG progression Jpn X @XOJPofficial | Powered by @suinetwork @hashed_official @unopnd_Official
• The FishVerse — FishVerse combines GameFi, AI, and blockchain technology, allowing players to fish in a dynamic open environment from their own homes.
• NXI — Nexus Interactive gives collective growth and accrued value to its ecosystem.

Portfolio highlights

• Wicrypt — Wicrypt is a dynamic organization that consistently allows its users to get paid by sharing their Wi-Fi.
• Gamic — Africa's biggest gaming guild.
• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.

Portfolio highlights

• Anoma — Anoma is the distributed operating system that frees builders from blockchain complexity. Build apps that are easy, private, and compatible with any chain.
• Keplr — Introducing the first, and leading, IBC-enabled wallet for Cosmos and beyond
• Datachain — Datachain is a tech company that revolutionizes blockchain interoperability and stablecoin settlement. we aim to make it possible for the world to interact as one network, making it easier to use a variety of services.

Portfolio highlights

• Outer Ring — Enter a vast sci-fi universe where five species fight for dominance. Explore, craft, conquer and own your destiny in Outer Ring MMO.
• Infinity Arena — The place to connect players who love tactical card games or have passionate about collecting valuable and rare NFT cards.
• Ancient Kingdom — Ancient Kingdom is the first ancient martial arts game on the blockchain platform, pioneering the realization of real-time games on the blockchain platform.

Portfolio highlights

• AHAlife — AHAlife is a fashion-based e-commerce platform connecting designers, brands, and publishers to individuals. The company's mission is to connect the best the world has to offer with discerning individuals from around the world. It is a discovery shopping destination for curated lifestyle products that span design, technology, fashion, media,food, beauty, and travel. Its platform sits at the intersection of content, commerce, and curation.
• Lolly Wolly Doodle — Lolly Wolly Doodle is passionate about providing families across the country with beautiful, high-quality and affordable apparel and accessories. It believes deeply in the importance of American manufacturing and are proud to manufacture over 50% of their items entirely in their Lexington factory.
• Meteor Entertainment — Meteor Entertainment engages in developing and publishing video games. The company was incorporated in 2011 and is based in Seattle, Washington.

Portfolio highlights

• Delabs Games — At Delabs Games, we want to create fun games that last a thousand years.
• PublicAI — PublicAI is a Web3 distributed AI training network that helps people to earn rewards by contributing data work.
• Power Protocol — The ecosystem for blockchain entertainment. Fueled by $POWER. Launch Partner: @Fableborne Power Up Your Play

Portfolio highlights

• TronBank.Pro — TronBank is a Tron energy leasing and TRX staking protocol
• TradingRazor — TradingRazor is an AI-native trading decision and market intelligence platform engineered specifically for multi-chain cryptocurrency and decentralized finance (DeFi) markets. Rather than acting as an asset custodian or execution venue, the system serves as a predictive analytics layer that tracks fragmented on-chain capital flows, cross-marketdata, and emerging arbitrage opportunities.
• Block Security Arena — Block Security Arena is a next-generation Web3 security learning platform that leverages AI-powered quizzes, immersive hands-on Capture The Flag (CTF) challenges, and expert-led video courses to help developers, security researchers, and blockchain enthusiasts build real-world skills in identifying, understanding, and mitigating smart contract andblockchain security vulnerabilities.

Portfolio highlights

• BRKT — Join the fun on BRKT! Make predictions on sports, pop culture, and more!
• GAIB — GAIB is the economic foundation for the future of artificial intelligence and computers. GAIB is a crypto-AI platform under development that tokenize GPUs, making AI computing—the processing power required to train and run AI models—more accessible.
• Yala — Yala operates a multi-token system and unlocks a thriving and interconnected DeFi ecosystem on Bitcoin​.

Portfolio highlights

• Datagram — Datagram is an AI-driven, decentralized infrastructure platform operating as a DePIN baselayer. The company provides a live, scalable node network for launching custom DePIN networks and real-world decentralized applications, with cost savings over traditional cloud providers.
• Ooga Booga — Multichain Liquidity Aggregator
• Accountable — Accountable is the new standard for real-time financial verification. Prove assets and liabilities privately, powered by the Data Verification Network (DVN).

Portfolio highlights

• BRKT — Join the fun on BRKT! Make predictions on sports, pop culture, and more!
• Dinari — Discover Equity Boundless - Simplify everything from equity management and options grant to payroll so that you no longer have to worry about compliance, taxes, or vesting schedules no matter where your employees are.
• BitcoinOS — BitcoinOS is a Decentralized Finance company that builds and develops Bitcoin ecosystem.

Portfolio highlights

• BRKT — Join the fun on BRKT! Make predictions on sports, pop culture, and more!
• RedStone — RedStone delivers frequently updated, reliable and diverse data for your dApp and smart contracts.

Portfolio highlights

• Splyce Finance — dETF protocol. Permissionless, on-chain index- and yield ETFs.