Top 50 SaaS Startup Investors in Panama (October 2026)

Portfolio highlights

• EBR Systems — EBR aims for outstanding treatment of cardiac rhythm diseases with an innovative leadless therapy.
• Cardiac Dimensions — Cardiac Dimensions, Inc. is a medical device company developing novel interventional tools for the treatment of heart failure and the related condition of mitral valve regurgitation. Our product, the Carillon® Mitral Contour System®, is a groundbreaking, non-surgical device developed to treat functional mitral valve regurgitation. Our system uses acatheter based approach to reshape the mitral valve and reduce mitral regurgitation.
• Ignite Tournaments — Empower content creators to launch custom quest lines, track fan engagement, and manage premium subscription communities.

Portfolio highlights

• Rivalz Network — Join the connectivity infrastructure between AI Agents, DeFAI and Markets.
• The Arena — A next gen SocialFi app redefining how creators connect, engage, and monetize their content.
• Sigma Computing — Sigma is the only BI analytics tool purpose-built for your cloud data warehouse. Uniquely scalable, with an experience you already know: the spreadsheet.

Portfolio highlights

• OP_NET — OPNET is a Bitcoin Layer 1 metaprotocol that enables smart contracts to function directly on the Bitcoin blockchain, without the use of sidechains or Layer 2 solutions.
• Watch.fun — Open boxes, collect watches. Pull a Rolex today. Authenticated by Wristcheck. Backed by @SolanaVentures
• Space — Space is a leveraged prediction market platform built on Solana, designed to reward users for accurate insights while enabling efficient capital flow through competitive forecasting, combining high-performance blockchain infrastructure with advanced market mechanisms to create a transparent, scalable, and engaging environment for decentralizedprediction and informed decision-making.

Portfolio highlights

• A-World — Welcome to Animal World, a battle game based on #BNBCHAIN's super metaverse card tower defense. By setting up a hero tower to destroy monsters.
• NeuronX — The First AI-Driven Lending Protocol on @dfinity
• Vue Protocol — Community-First Layer for AI Memecoins. @solana @pumpdotfun @ton_blockchain Dvo1Fb7FxtUxsLbcQaizftfUT9HtL9P6swaQAScZDeQQ

Portfolio highlights

• OpenPad AI — OpenPad - The 1st AI Decentralized Launchpad
• Stabble — Stabble is the first frictionless exchange protocol on Solana that eliminates financial losses for all DeFi users.
• AI Cross Matrix — AI Cross Matrix is a DeFi platform that makes the crypto economy simple by streamlining the exchange process with useful solutions.

Portfolio highlights

• Neosoul — NeoSoul uses an open architecture with autonomous agents operating under user-defined constraints to link agent intelligence, deterministic capital controls, and verifiable market execution.
• ORO — ORO is an AI-powered DeFi companion that lets users manage, trade, stake, lend, and research crypto assets through natural-language conversations, ORO aims to simplify onchain finance by bringing portfolio management and DeFi actions into one conversational interface.
• GAEA — GAEA is a decentralized artificial intelligence training network and data infrastructure platform focused on building a comprehensive multimodal emotional database.

Portfolio highlights

• Quotr.ai — Quotr.ai is the all-in-one pre-construction engine built to bridge the costly "takeoff-to-transaction" gap for modern subcontractors, contractors and developers. The San Francisco-based platform serves every construction trade by consolidating fragmented workflows into a single workspace. Instead of bouncing between disjointed tools,users can seamlessly transition from advanced AI takeoffs and estimates to competitive bidding, material procurement, and developer proformas. To directly improve project margins, Quotr.ai integrates dynamic material list matching, connecting users with diverse suppliers to source materials cheaper and faster. Quotr.ai enables teams to slash material costs by up to 40% and cut estimation time by 90%, bringing modern, high-ROI software to one of the world's largest industries. Backed by Llama Ventures, Quotr.ai is rapidly becoming the platform of choice for forward-thinking construction firms with a mission to make pre-construction faster, easier, and more accurate.
• AEON — Powering #agenticeconomy #x402 | AEON is settlement layer bridging autonomous AI interactions (A2A & A2M) with real-world value flows. Backed by @yzilabs $AEON
• KOR Protocol — KOR Protocol is a decentralized intellectual property (IP) infrastructure designed to empower creators, protect rights, and enable seamless collaboration and monetization of IP assets across various industries, including music, film, TV, gaming, and art. Backed by notable entities like Animoca Brands, Republic, Niantic, Sfermion, Solana, andprominent creators such as Black Mirror, Disclosure, deadmau5, and Richie Hawtin, KOR leverages blockchain, AI, and DeFi to offer a transparent, efficient, and scalable environment for IP expansion.

Portfolio highlights

• Superlogic — OneOf is the mass-consumer Web3 company connecting the next 100M non-crypto-native fans to iconic brands, artists, and athletes. OneOf technology enables global brands and enterprises to reimagine commerce, loyalty and engagement, allowing consumers to seamlessly collect or trade digital assets with no prior crypto expertise. Deeply committed to a sustainable and inclusive blockchain future, minting digital assets on OneOf's platform uses up to 2 million times less energy than previous generation proof-of-work networks, and costs up to 99% less in gas fees. A leader in diversity, over 80% of the collections curated by OneOf come from minority or female creators.
• PERPTools — PERPTools combines crypto perpetual trading with activity points and risk-free market predictions.
• Slinky Network — Slinky Network provides an on-chain marketplace and payment protocol that connects AI agents and applications with third-party APIs. The company offers the SlinkyLayer platform, which wraps developer endpoints as discoverable skills and exposes them through an x402 pay-per-execution interface. Each API call triggers a non-custodial on-chainmicropayment, settling in the same request loop using networks such as Base and BNB Chain. Developers set prices, earn a defined revenue share, and receive instant payouts to their wallets without subscriptions or custodial holds. AI agents authenticate via wallet signatures, enabling autonomous, machine-to-machine access and payment without traditional logins or credit cards. The platform also records call ratings on-chain to provide portable, verifiable reputation for services.

Portfolio highlights

• Wizzwoods — 1st pixel farm game integrates interchain capabilities with a SocialFi twist.
• SuperIntent — SuperIntent is a cryptocurrency AI app that streamlines on-chain earning tactics. Developed on a multi-agent framework with abundant yield sources.
• SuperGaming — At SuperGaming, we are putting India on the global gaming map.

Portfolio highlights

• Meta Pool — The liquid staking layer for the onchain economy
• Amnis Finance — Stake APT on the best liquid staking protocol on Aptos to receive daily rewards with an attractive APR of 2%.
• Velvet Capital — Velvet Capital is a DeFi operating system that helps launch and manage on-chain funds and structured products. Velvet Capital offers its users a way to gain exposure to digital assets.

Portfolio highlights

• MSafe — MSafe offers the most secure, decentralized, scalable Web3 non-custodial, multi-signature solution built on Move, ideal for dApp developers to use for treasury management, token management, smart contract development, blockchain protocol admin control, live on Aptos
• Polysights — Leverage intelligence to optimize your strategy on @Polymarket
• Turtle Club — Aggregated, diligenced, personalized onchain yield management.

Portfolio highlights

• SQR3D — Transform your idea into 3D assets at scale. Smart Contract Automation for 3D Designs with SQR3D.
• Reitio Protocol — We’re creating an effortless way for everyone to create custom metaverse assets visually via an intuitive and codeless templates-based design toolkit, introducing reitio protocol.
• Genesis Shards — Crafting a whole new suite of NFT powered products across multiple blockchains

Portfolio highlights

• DHL — DHL is a division of the German logistics company Deutsche Post DHL that provides international express mail services. Deutsche Post is a large-scale logistics company operating around the world. DHL provides world market services both in sea and air mail.DHL was primarily interested in offshore and inter-continental deliveries, but the successof FedEx prompted its own intra-U.S. expansion starting in 1983. DHL aggressively expanded to countries that could not be served by any other delivery service, including the Soviet Union, Eastern Bloc, Iraq, Iran, China, Vietnam, and North Korea.Deutsche Post then effectively absorbed DHL into its Express division, while expanding the use of the DHL brand to other Deutsche Post divisions, business units and subsidiaries.Originally founded in 1969 to deliver documents between San Francisco and Honolulu, the company expanded its service throughout the world by the late 1970s. DHL was founded in 1969 and is based in Bonn.
• ShoeFy — ShoeFy is a decentralized project that combines nonfungible tokens (NFTs) and fungible tokens (FTs) on one platform to add new utility layers to NFTs.

Portfolio highlights

• ShoeFy — ShoeFy is a decentralized project that combines nonfungible tokens (NFTs) and fungible tokens (FTs) on one platform to add new utility layers to NFTs.
• CryptoTanks — CryptoTanks is a play-to-earn platform where every NFT is usable in a gamified DeFi ecosystem. With the tanks, the player earns money and plays games partially owned and operated by their players. Earn tank tokens by playing and use them to decide the future of the game. They offer design and prizes that come with gamified yield farming.
• Astra Guild Ventures — Astra Guild Ventures is one of the world's play-to-earn gaming guilds. Astra Guild Ventures is bridging the gap between players and investors in order to capitalize on the growth of non-traditional games.

Portfolio highlights

• Treyee — Engineering AI solutions and products that empower enterprises to achieve results through adaptive business and personal automation

Portfolio highlights

• 3VO — Bring Your Business On-chain. The easiest way to launch, grow, and own your brand with AI + Web3 tools - all in one simple, social platform.

Portfolio highlights

• Treyee — Engineering AI solutions and products that empower enterprises to achieve results through adaptive business and personal automation

Portfolio highlights

• SnakeLite — 10-min prediction markets on Hyperliquid whale positions, BTC and ETH. Predict up or down. Settle onchain. From the 100M+ download SnakeLite game.
• Sophon — Soph(+) is a tech studio building novel consumer experiences in crypto and ai. we build, own, and ship our own products, starting with pyre.
• A.A.A C(H+A)RM — AAA C(H+A)RM (Autonomous AI Agents Launchpad & Layer3) is the first AI-first, agent-focused orchestration platform.

Portfolio highlights

• Capx — Capx's mission is to accelerate the flow of capital through the private markets, thereby enhancing global capital allocation. With secondary market and enterprise solutions, Capx combines high-quality collections of opportunities with efficient access for institutions and individual investors.
• DeepSafe — The world's first Cryptographic Random AI Verification Network for trustless verification of any on-chain and off-chain messages.
• aPriori — aPriori is a monad-native MEV infrastructure and liquid staking mechanism developed for parallel executions.

Portfolio highlights

• GAMES.GG — Discover 1,500+ games with honest reviews, expert guides, and daily gaming news across PC, console, and mobile. Find your next favorite game on Steam, Epic Games, PlayStation, Xbox, and Nintendo.
• Sumer Money — Sumer Money is a cross-chain synthetic assets protocol that enables composable Defi across blockchains.
• SYNTRA — Live AI trading system. Real-time execution, risk-managed positions, public trade feed. Signals, performance, transparency.

Portfolio highlights

• Bluwhale — Unlock Web3 Wallet Potential with AI Insights. Supercharge Your Business Growth
• BluWhale — Premium domain available for acquisition.
• Sorted Wallet — Sorted Wallet simplifies crypto transactions for feature phones in emerging markets.

Portfolio highlights

• Ignite Tournaments — Empower content creators to launch custom quest lines, track fan engagement, and manage premium subscription communities.

Portfolio highlights

• myco — myco is a content streaming super dApp that smoothly integrates AVOD and SVOD capabilities into a decentralized ecosystem.
• Metametaverse — Discover the future of virtual worlds with our metaverse platform. Explore, create and monetize your own metaverse experiences in a seamless and secure manner. Join the cosmic system of metaverses today.
• Ignite Tournaments — Empower content creators to launch custom quest lines, track fan engagement, and manage premium subscription communities.

Portfolio highlights

• OX.FUN — Trade Bitcoin, Ethereum and trending altcoin derivatives on the most FUN exchange around. Join OX.FUN today and earn up to 200% yield. Moo.
• AINN Layer2 — AINN Layer2 is a decentralized Bitcoin Layer2 network development.It promotes large-scale AI applications
• Sanctum — Stake SOL and earn optimized LST returns from JupSOL, bbSOL, and more, and launch your own custom LST and Solana validator.

Portfolio highlights

• Kapkap — Kapkap is a web3 platform that uses AI for attention based value distribution in gaming.
• SuperIntent — SuperIntent is a cryptocurrency AI app that streamlines on-chain earning tactics. Developed on a multi-agent framework with abundant yield sources.
• Inference Labs — AI hyperscale on decentralized networks - We provide certainty for on-chain AI

Portfolio highlights

• CESS — CESS is a blockchain-based, decentralized Layer-1 infrastructure that integrates distributed storage, a high-speed content delivery network.
• Dmail — Dmail Network is a decentralized mailbox that provides a safe and private environment for users' communication, storage, tokens, and NFTs. The company was founded by Mittal S. and Lucas L. in 2021.
• Cumulus Encrypted Storage System (CESS) — CESS revolutionizes AI, DeSci, RWA, Enterprise, and more with secure, transparent, and traceable data solutions. Delivering AI computing and data infrastructure, CESS enables data privacy and sovereignty with a focus on AI Agent applications and frameworks.

Portfolio highlights

• Spicenet — Spicenet is a hyper-fast Layer 2 (L2) trading solution, engineered as a custom application rollup to deliver ultra-fast, reliable, and efficient transaction processing for seamless trading experiences.
• Real Finance — Real Finance is driven by the mission to revolutionize the financial landscape by integrating real-world assets with blockchain technology, creating a more transparent, secure, and efficient ecosystem that bridges traditional finance with decentralized innovation, enhances asset liquidity, and unlocks new opportunities for global investors.
• WorkQuest — About WorkQuest WorkQuest is a decentralized employment and workforce automation protocol enabling employers and workers to collaborate through smart contracts, stablecoin payments, AI matching engines, and on-chain reputation scoring. The platform transforms global employment into a transparent, verifiable, and borderless digital labor economy.

Portfolio highlights

• Yellow — Yellow is a financial services provider of software, analytics, and investments in blockchain startups.
• KIP Protocol — KIP Protocol is a decentralised AI framework unlocking digital property rights of Knowledge Assets in the AI-powered future.
• Alliance Games — Build Beyond Limits. Multiplayer for the Next, Decentralized Era.

Portfolio highlights

• TronBank.Pro — TronBank is a Tron energy leasing and TRX staking protocol
• TradingRazor — TradingRazor is an AI-native trading decision and market intelligence platform engineered specifically for multi-chain cryptocurrency and decentralized finance (DeFi) markets. Rather than acting as an asset custodian or execution venue, the system serves as a predictive analytics layer that tracks fragmented on-chain capital flows, cross-marketdata, and emerging arbitrage opportunities.
• Block Security Arena — Block Security Arena is a next-generation Web3 security learning platform that leverages AI-powered quizzes, immersive hands-on Capture The Flag (CTF) challenges, and expert-led video courses to help developers, security researchers, and blockchain enthusiasts build real-world skills in identifying, understanding, and mitigating smart contract andblockchain security vulnerabilities.

Portfolio highlights

• Demole — Demole is a play to earn NFT gamification platform.
• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.
• Radom — A Decentralised Network for Coordination of Cloud Applications and Connected Assets

Portfolio highlights

• Wicrypt — Wicrypt is a dynamic organization that consistently allows its users to get paid by sharing their Wi-Fi.
• Gamic — Africa's biggest gaming guild.
• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.

Portfolio highlights

• Thyme Care — Thyme Care is a dedicated team of nurses and care experts offering value-based cancer care to help you through all phases of the cancer experience.
• Deon Health — Deon Health is a specialty managed care organization focused on individuals with intellectual and developmental disabilities. The company partners with home- and community-based services providers and health plans through joint ventures and limited-risk arrangements. It offers care coordination platforms, actuarial services, regulatory compliancesupport, and health plan operations. Deon Health integrates Medicaid and Medicare benefits, uses predictive analytics and a risk-stability framework, and connects direct support professionals, families, and clinicians. Its services aim to reduce fragmented care, support caregivers, and improve person-centered outcomes.
• Angle Health — Angle Health provides a technology-enabled health insurance platform to simplify employer-sponsored healthcare benefits.

Portfolio highlights

• Starbots — Starbots is Solana's first-ever battle NFT game.
• Linear — Linear allows the user to manage software development and track bugs. Built for speed and efficiency.The founders started Linear from their own frustrations building software projects in successful high-growth companies like Airbnb, Coinbase and Uber. The founders wanted to create the tools that focus us and its team in making progress, not getin the way. Tools that are fast and efficient. Speed and performance were the main things Linear focuses on early on and keep focusing on that.
• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.

Portfolio highlights

• BRKT — Join the fun on BRKT! Make predictions on sports, pop culture, and more!
• Gata — Gata uses data technology to develop superintelligence and to ensure its alignment with human objectives.
• Algebra.Finance — Algebra.Finance is the Financial Services.

Portfolio highlights

• Altcoinist — Altcoinist is an interoperable community gating infrastructure that transforms private communities into vibrant on-chain economies by bringing cutting-edge token gating, community staking pools, and enabling new revenue sources for creators and communities.

Portfolio highlights

• 54gene — 54gene is a healthcare startup unlocking the African genome to fuel genetic research and development that may lead to new discoveries and benefit all populations.54gene was founded in 2019 by Dr. Abasi Ene-Obong to address the significant gap in the global genomics market: Nearly 90% of genetic material used in pharmaceutical research iscaucasian. Only 2% is African, despite the fact that Africans and people of African ancestry are more genetically diverse than all other world populations combined. As a result, pharmaceutical research and development is lacking the diverse data that may hold the key to medical discoveries and new healthcare solutions.
• Betterhalf — Best matrimony app in India with AI matchmaking. Get compatible life partner from lakhs of genuine, Govt ID and selfie verified profiles of brides & grooms. Download Betterhalf marriage app now!
• SOS Hydration — Rescue yourself from dehydration with SOS, doctor formulated rapid hydration with 80x less sugar than sports drinks and only 3g carbs and 10 calories.

Portfolio highlights

• Ankr — Get faster, more reliable multi-chain development tools
• WOO Network — Discover WOO's ecosystem of centralized and decentralized apps to seize every opportunity in crypto.
• AllianceBlock — AllianceBlock is now Nexera. Follow us on @Nexera_Official

Portfolio highlights

• Pixelverse — We build Telegram games with memecoins communities. Play here: https://t.co/NH6j76YaZy Powered by $PIXFI
• Mavryk Dynamics — Real assets, Real people, Real solutions. Building a smarter, more secure future. Blockchain, Done Better. Building @MavrykNetwork & @MavenFinanceDAO.
• Swarm Network — Agentic infra for the future $TRUTH NEW: Build your Future agent teams in beta

Portfolio highlights

• 5ire — 5ire is a blockchain network that brings sustainability, technology, and Innovation to build the 5th industrial revolution (5IR). The mission of the 5ire ecosystem is to embed the for-benefit paradigm at the heart of the blockchain, highly incentivize practices that align with the United Nations Sustainable Development Goals (SDGs), facilitate thetransition from the 4IR to 5IR and accelerate the implementation of the UN 2030 Agenda for Sustainable Development. The company's primary offering is 5ireChain, a layer one, sustainability-driven 5th generation blockchain that ensures adherence to the philosophy of 5IR, creating a net positive impact on the planet and serving humanity.
• Polygen — Polygen provides a breath of fresh air in the world of blockchain launchpads. Current solutions all foster innovation on a specific blockchain, but they also look and operate the same. Fueling innovation in this industry requires the removal of all intermediaries and gatekeepers. Additionally, there is a need for more transparency, automatedprocesses, and post-launch support.
• Ignite Tournaments — Empower content creators to launch custom quest lines, track fan engagement, and manage premium subscription communities.

Portfolio highlights

• BAYZ — NFT Gaming Startup | Esports & Content Community HUB | #PlayToEarn
• UNXD — UNXD is a curated NFT marketplace for the best of digital luxury and culture. Featuring NFTs from Dolce&Gabbana, Jacob & Co., and more.
• Mon Studios — An indie game development studio

Portfolio highlights

• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.
• Xion Finance — Xion Finance is the easiest way to start earning a passive income on your crypto. Earn interest, shop products or yield farm with a novel one click to DeFi protocol. Get Started Today!
• QANplatform [QAN blockchain platform] — QANplatform is the quantum-resistant Layer 1 hybrid blockchain where developers can code web3 solutions in any language on top of the QAN blockchain platform.

Portfolio highlights

• GAMES.GG — Discover 1,500+ games with honest reviews, expert guides, and daily gaming news across PC, console, and mobile. Find your next favorite game on Steam, Epic Games, PlayStation, Xbox, and Nintendo.
• Flappy Bird — Flappy Bird Foundation is to uphold the Flappy Bird intellectual property and further the Flappy Bird heritage. The Foundation accurately restores our vintage and nostalgic gameplay while adding new features to give back to the worldwide fan base that started the craze.
• Community Labs — Community Labs is a software development company and venture studio focused on accelerating developer tools, use cases, and adoption of Arweave and AO.

Portfolio highlights

• Altcoinist — Altcoinist is an interoperable community gating infrastructure that transforms private communities into vibrant on-chain economies by bringing cutting-edge token gating, community staking pools, and enabling new revenue sources for creators and communities.

Portfolio highlights

• Elusiv — Elusiv offers compliance in mind with next-generation privacy solutions for a better Web3.
• TipLink — TipLink helps send crypto with a link. Someone with crypto can create a account and send that link to anyone over any platform. It’s like buying a gift card, connect the client's crypto wallet of choice and create a account by depositing how much they want to send.
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• Nexio — Making Bitcoin Productive
• Turtle Club — Aggregated, diligenced, personalized onchain yield management.
• Neutral Trade — Quant Strategies Marketplace backed by @yzilabs @incubator @drwtrading | Official Links: https://t.co/LducMMG0ly

Portfolio highlights

• Altcoinist — Altcoinist is an interoperable community gating infrastructure that transforms private communities into vibrant on-chain economies by bringing cutting-edge token gating, community staking pools, and enabling new revenue sources for creators and communities.

Portfolio highlights

• Composable Corp — Composable Corp is a blockchain financial application developer.
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• Pivo — Pivo is an all-in-one financial services platform for businesses in the supply chain. Set up accounts, access credit and manage your finances in one simple application.
• StackAI — Stack AI supercharges businesses. Deploy AI-powered applications in minutes, automate processes, and skyrocket productivity by connecting LLMs to data sources using Stack AI's no-code platform. Export your work with user-centric interfaces (chatbots and forms) and developer-friendly APIs.
• Kapital — Kapital empowers SMBs with a tech-banking platform giving visibility and control of their treasury, and their employees

Portfolio highlights

• Caden — Caden is the world's first Zero-Party Data platform. We allow users to own and control their own personal data, make money off it, and share it with trusted consumer brands, while maintaining their privacy.
• Dashy Dash — Dashy Dash is a free community powered tool that makes it easy to manage invoices, discover new products & compare prices to help you save money.
• Vero Technologies — Vero Technologies is a Financial Services based company.

Portfolio highlights

• PACT — PACT designs Elegant materials produced in tune with the planet earth. It create revolutionary, sustainable biomaterials using the earth's resources, including collagen, herbal extracts, oils, and minerals.
• Rove — Claim your spot on the waitlist for the first ever travel credit card for Gen Z.
• Magrathea — Magrathea Metals is a mining company that unlocks centuries of growth in human civilization by reducing the socioenvironmental impacts.