Top 50 SaaS Startup Investors in Panama (June 2026)

Portfolio highlights

• Aark — Trade crypto perpetuals with up to 1000x leverage, zero gas fees, and an industry-low 0.01% trading fee. Earn payback on losses with VIP rewards. RWA & altcoin perps on Arbitrum. Backed by OKX Ventures.
• Ta-da — We collect, annotate, and label audio, image, video, and text data to power your AI training. From voice and facial recognition to biometrics and object detection, we build tailored datasets for your needs.
• Itheum — As we enter the web3 and metaverse era; Itheum unlocks data silos and generates new value for your data.

Portfolio highlights

• The Arena — A next gen SocialFi app redefining how creators connect, engage, and monetize their content.
• Joystream — Joystream is a block chain-based, decentralized video platform.
• Sigma Computing — Sigma is the only BI analytics tool purpose-built for your cloud data warehouse. Uniquely scalable, with an experience you already know: the spreadsheet.

Portfolio highlights

• SnakeLite — Snake Lite is a classic arcade snake game with a competitive edge and offers offline and online play. It is designed for smooth controls and fast performance.
• Eizper Chain — Eizper Chain is a blockchain action online multiplayer role-playing game that celebrates adventure and arena battle.
• A.A.A C(H+A)RM — AAA C(H+A)RM (Autonomous AI Agents Launchpad & Layer3) is the first AI-first, agent-focused orchestration platform.

Portfolio highlights

• Ignite Tournaments — Ready to take your mobile games to the next level? Join Ignite Tournaments and compete in real money esports tournaments. Download our app now and win big!

Portfolio highlights

• GAMES.GG — Discover 1,500+ games with honest reviews, expert guides, and daily gaming news across PC, console, and mobile. Find your next favorite game on Steam, Epic Games, PlayStation, Xbox, and Nintendo.
• Snackclub — Learn more about play to earn games
• SYNTRA — Syntra is an AI-driven trading infrastructure company focused on disciplined execution, real-time risk management, and transparent market operations in digital asset markets. The company builds systems that monitor market structure, volatility, liquidity, and correlation dynamics, enabling automated decision-making with strict risk controls.Syntra’s infrastructure is designed to prioritize execution quality, capital preservation, and operational transparency over short-term performance optimization.Syntra operates a live execution environment where all system actions are observable in real time, providing an open view into how the trading system behaves across different market conditions. The platform is infrastructure-first, emphasizing robustness, scalability, and controlled growth rather than aggressive user acquisition. The company is currently focused on expanding its execution stack, data pipelines, and risk management framework to support broader market coverage and institutional-grade reliability.

Portfolio highlights

• AEON — AEON is a crypto payment framework designed for AI-driven and real-world transactions. It supports omni-chain payments across ecosystems like EVM, SVM, and TON, enabling seamless cross-chain usage. Its solutions include AI-powered payments, Web3 online and mobile payments, QR/contactless acceptance, and swap pay, all designed to simplifyadoption for users and merchants.
• AlchemyNFT — AlchemyNFT is a non-fungible token (NFT) service.
• Limited — Secure your treasury and scale your business globally with a truly self-custodial account that only you control. No banks. No middlemen.

Portfolio highlights

• Bluwhale — Unlock Web3 Wallet Potential with AI Insights. Supercharge Your Business Growth
• Novastro — Novastro is a Layer 2 chain for RWAs powered by AI that integrates MoveVM and EigenLayer AVS, delivering Ethereum-level security and Move’s scalability to unlock tokenised yield opportunities across RWAs & DeFi protocols.
• BluWhale — BluWhale's mission is to leverage AI and ML to allow game developers to focus on ways to improve the game rather than wrangling and making sense of astronomical amounts of data. BluWhale's smart automation will do the heavy lifting usually reserved for data analysts and data scientists all in the background, and surface actionable insight

Portfolio highlights

• MetaJuice — MetaJuice is building blockchain-driven assets that unlock the value of the metaverse where users can create, earn, own and shape the future. Through meta tokens such as VCORE and VCOIN, and NFTs, MetaJuice will realize its vision; creating a world where everyone can participate and share in its success.
• Ceramic Network — Ceramic Network is a provider of protocols for decentralized and composable data applications. The network decentralizes application databases, making data universally composable and reusable across applications. It consists of three core parts: a highly-scalable, decentralized infrastructure for data availability and consensus, a marketplace ofcommunity-created data models, and a suite of standard APIs for storing, updating, and retrieving data from those models.
• Saltwater Games — Saltwater Games create unique XR games and provide gamers with an platform that prioritises the fun of immersive play and economic longevity via AAA experiences with innovative decentralised ownership.

Portfolio highlights

• Metatheory — Metatheory Inc. is an interactive technology and entertainment company building Web3 games, interactive content, social experiences, and other community-driven adventures. Metatheory’s mission is to inspire imagination by connecting people worldwide through immersive worlds built on cross-generational IP.
• Pagos Solutions — Get real-time payment data detecting issues, trends, and opportunities plus intelligent payment solutions for optimizing payment performance.
• Spaceport Technologies — Accelerating the growth of the next digital economy

Portfolio highlights

• EBR Systems — EBR aims for outstanding treatment of cardiac rhythm diseases with an innovative leadless therapy.
• Cardiac Dimensions — Cardiac Dimensions, Inc. is a medical device company developing novel interventional tools for the treatment of heart failure and the related condition of mitral valve regurgitation. Our product, the Carillon® Mitral Contour System®, is a groundbreaking, non-surgical device developed to treat functional mitral valve regurgitation. Our system uses acatheter based approach to reshape the mitral valve and reduce mitral regurgitation.
• Ignite Tournaments — Ready to take your mobile games to the next level? Join Ignite Tournaments and compete in real money esports tournaments. Download our app now and win big!

Portfolio highlights

• Turtle Club — Turtle aligns incentives between protocols and LPs to offer the best curated incentives in DeFi.
• Momentum — Momentum is a move central liquidity engine with multi-sig treasury management, token vesting, and liquidity provisioning.
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• Treyee — We engineer revolutionary AI products and solutions that redefine enterprise capabilities. Our cutting-edge technology transforms raw data into strategic intelligence, empowering organisations to dominate markets, automate at scale, and unlock unprecedented opportunities. We're building the future where ambitious enterprises lead throughintelligent innovation.

Portfolio highlights

• myco — myco is a content streaming super dApp that smoothly integrates AVOD and SVOD capabilities into a decentralized ecosystem.
• Metametaverse — Discover the future of virtual worlds with our metaverse platform. Explore, create and monetize your own metaverse experiences in a seamless and secure manner. Join the cosmic system of metaverses today.
• Ignite Tournaments — Ready to take your mobile games to the next level? Join Ignite Tournaments and compete in real money esports tournaments. Download our app now and win big!

Portfolio highlights

• GENCY AI — Gency AI is a Web3 platform for privacy-focused, verifiable digital ads using encrypted data and proof-based tracking.
• Voyage — Voyage AI is an AI infrastructure project building the first GEOFi network to make AI-generated content citable.
• Interstate — Interstate is an Ethereum pre-confirmation protocol. It aims to make Ethereum transactions near-instant and allow applications to self-order while maintaining full composability with L1.

Portfolio highlights

• Datagram — Datagram is an AI-driven, decentralized infrastructure platform operating as a DePIN baselayer. The company provides a live, scalable node network for launching custom DePIN networks and real-world decentralized applications, with cost savings over traditional cloud providers.
• Ooga Booga — Multichain Liquidity Aggregator
• Accountable — Accountable is the new standard for real-time financial verification. Prove assets and liabilities privately, powered by the Data Verification Network (DVN).

Portfolio highlights

• Altcoinist — Altcoinist is an interoperable community gating infrastructure that transforms private communities into vibrant on-chain economies by bringing cutting-edge token gating, community staking pools, and enabling new revenue sources for creators and communities.
• TigerBeetle — TigerBeetle operates as a distributed financial accounting database for mission-critical safety and performance.

Portfolio highlights

• Caden — Caden is the world's first Zero-Party Data platform. We allow users to own and control their own personal data, make money off it, and share it with trusted consumer brands, while maintaining their privacy.
• AnthologyAI — AnthologyAI is the breakthrough Artificial Intelligence Consumer Insights & Predictions Platform with billions of real-time data sourced directly and ethically from consumers. Access previously unavailable levels of intelligence about retail spending, geolocation, media consumption, travel, ride sharing and more — in realtime, at scale.
• Vero Technologies — Vero Technologies is a Financial Services based company.

Portfolio highlights

• Eywa — Founded in 2021, EYWA helps Web3 projects scale up by enabling them to operate, get listed, and traded on all connected blockchain networks with a single liquidity pool. Additionally, EYWA provides a truly decentralized data protocol for secure messaging.In partnership with Curve Finance, one of the largest decentralized exchanges, EYWA isintroducing a new paradigm of non-algorithmic cross-chain assets aimed at solving the problem of liquidity fragmentation. Their cross-chain protocol stands out as the most decentralized solution in the market.- Received 6 grants from biggest L1/L2 blockchain networks including NEAR Foundation, Aurora, Harmony One, Algorand, Boba Network, and others - Winning hackathons: Ethglobal Marketmake, Polygon’s BUIDL IT hackathon, Metis hackathon
• TG DAO 3.0 — TG DAO 3.0 is TG Ecosystem's launchpad for investing in conventional and crypto startups. All launchpad investors are considered to be co-owners and take part in the decision-making process for the launchpad functions. TG DAO 3.0 is a new crowdfunding blockchain launchpad on the TG Ecosystem that combines decentralized and centralizedinvesting, attracts mechanisms, and provides comprehensive support for startups.
• GoFungibles — GoFungibles is a cross-chain state-of-the-art NFT marketplace equipped with all the existing features of conventional NFT marketplaces but augmented with DeFi and gamified components.

Portfolio highlights

• BBy — BBy connects nursing mothers with couples who can't produce or do not produce enough breast milk to feed their child
• Careerist — Careerist is the connecting bridge between people without tech or coding background and the U.S. tech industry. We quickly train and apply our students for simple well-paid jobs like software testing, while helping them grow into more advanced roles.
• Legistify — Legistify offers AI-powered legal operations software to streamline workflows, manage contracts, track legal cases and improve productivity for enterprise legal teams

Portfolio highlights

• Bujeti — Bujeti is the finance control centre for African businesses. Manage expenses, automate payments, and issue corporate cards for total control and visibility.
• FlexDesk — FlexDesk is creating a new evolution of the flexible workspace model. Remote workers use the platform to discover and book a dedicated desk or private office by the day. FlexDesk unlocks this inventory by partnering with office landlords and coworking operators that have furnished, underutilized space.
• SearchEye — Get tech-driven SEO at scale, speed and a fraction of the cost compared to traditional agencies. Acquire PR Mentions, Digital PR and Content.

Portfolio highlights

• Prime Trust — Prime Trust powers innovation in the digital economy by providing fintech and digital asset innovators with financial infrastructure. Our API is customizable whether you're building a crypto exchange or expanding your business with digital assets.
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• BRKT — Join the fun on BRKT! Make predictions on sports, pop culture, and more!
• Dinari — Discover Equity Boundless - Simplify everything from equity management and options grant to payroll so that you no longer have to worry about compliance, taxes, or vesting schedules no matter where your employees are.
• BitcoinOS — BitcoinOS is a Decentralized Finance company that builds and develops Bitcoin ecosystem.

Portfolio highlights

• Aire — The income assessment platform that leverages first-party data. Access real-time confidence in the stated income of any consumer.
• Questflow — Questflow Labs seeking to give customers with an all-in-one solution for user intent perception and distribution, AI agentic workflow automation, and human-AI cooperation. Questflow Labs is pioneering a novel approach to decentralized AI agentic workflow.
• Flare — Flare equips your team to shut down cybercrime before it escalates. Detect, prioritize, and remediate external cyber threats with automated Threat Exposure Management.

Portfolio highlights

• Munily — Munily, a proptech software, Is redefining security and administration in residential communities by centralizing all communications.
• Shippify — Shippify is an innovative logistics service that connects businesses with a diverse network of drivers & 3PLs to provide same day delivery . Shippify is backed by strategic leading venture capital and angel investors. Currently available in Brasil, Mexico, Chile and Ecuador. The company was founded in 2014.

Portfolio highlights

• Splyce Finance — dETF protocol. Permissionless, on-chain index- and yield ETFs.

Portfolio highlights

• 375ai — 375ai is an edge data intelligence network on Solana that provides advanced real-time data collection and analysis to power a smarter, more connected world.
• Moku — Moku is a web3 gaming platform that enables players connect to gaming guilds, NFT casting pages, game strategy communities, and more.
• Skyfire Systems — Skyfire, a financial stack designed to enable autonomous agentic AI commerce, is to establish the first fully autonomous, open agentic AI economy in history.

Portfolio highlights

• Munily — Munily, a proptech software, Is redefining security and administration in residential communities by centralizing all communications.

Portfolio highlights

• Altcoinist — Altcoinist is an interoperable community gating infrastructure that transforms private communities into vibrant on-chain economies by bringing cutting-edge token gating, community staking pools, and enabling new revenue sources for creators and communities.

Portfolio highlights

• Multisynq — Multisynq is a decentralized and low-latency synchronization network.
• The Arena — A next gen SocialFi app redefining how creators connect, engage, and monetize their content.
• Altcoinist — Altcoinist is an interoperable community gating infrastructure that transforms private communities into vibrant on-chain economies by bringing cutting-edge token gating, community staking pools, and enabling new revenue sources for creators and communities.

Portfolio highlights

• XOCIETY — The XOCIETY metaverse is being developed by a well-established team of over 50 developers with decades of experience in the tech and web2 gaming fields.
• The FishVerse — FishVerse combines GameFi, AI, and blockchain technology, allowing players to fish in a dynamic open environment from their own homes.
• NXI — Nexus Interactive gives collective growth and accrued value to its ecosystem.

Portfolio highlights

• Biconomy — Blockchain transactions made simple. Enable Gasless meta-transactions, instant cross-chain transfers, easy layer 2 onboarding & zero failed transactions
• ZAP — ZAP offers a reputation-based token distribution protocol that supports fair rewards for user contributions within the Blast ecosystem. It enables users to participate in various projects through missions and seamless investment options. Additionally, ZAP is expanding its services to other blockchains and developing tools to simplify access toventure-capital-backed projects.
• Velvet Capital — Trade any crypto onchain - spot and perpetuals across 7 chains with AI-powered routing. Non-custodial DeFi trading terminal + AI trading bot. 100K+ traders.

Portfolio highlights

• EclipseFi — EclipseFi is a Cosmos modular multi-chain token issuance platform that seeks to tackle Launchpad's cross-chain user experience and sustainability challenges with features like smart accounts and cross-chain design.
• Term Labs — Fixed rate lending for everyone
• Nexio — Nexio is a bitcoin scaling solution platform that helps to improve cryptocurrency's scalability by using parallelizing Bitcoin rollouts.

Portfolio highlights

• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.
• Xion Finance — Xion Finance is the easiest way to start earning a passive income on your crypto. Earn interest, shop products or yield farm with a novel one click to DeFi protocol. Get Started Today!
• QANplatform [QAN blockchain platform] — QANplatform is the quantum-resistant Layer 1 hybrid blockchain where developers can code web3 solutions in any language on top of the QAN blockchain platform.

Portfolio highlights

• Anoma — A sovereign, proof-of-stake blockchain protocol that enables private, asset-agnostic cash and private bartering among any number of parties.
• Keplr — Introducing the first, and leading, IBC-enabled wallet for Cosmos and beyond
• Datachain — Datachain is a tech company that revolutionizes blockchain interoperability and stablecoin settlement. we aim to make it possible for the world to interact as one network, making it easier to use a variety of services.

Portfolio highlights

• Dmail — Dmail Network is a decentralized mailbox that provides a safe and private environment for users' communication, storage, tokens, and NFTs. The company was founded by Mittal S. and Lucas L. in 2021.
• OMNIA Protocol — OMNIA Protocol offers a secure and private infrastructure for accessing blockchain technology. It provides high availability RPC endpoints for Ethereum, ensuring users can connect to the blockchain without being traced or monitored. The company focuses on delivering a compliant environment for handling personal data, including blockchain addressesand transactional information. OMNIA Protocol aims to democratize access to blockchain infrastructure, challenging the current concentration of this access among a few corporations. It supports various blockchains, including Bitcoin, Binance, Avalanche, Polygon, Arbitrum, and Optimism, through its platform, offering secure Arbitrum RPC Nodes features.
• Cumulus Encrypted Storage System (CESS) — CESS revolutionizes AI, DeSci, RWA, Enterprise, and more with secure, transparent, and traceable data solutions. Delivering AI computing and data infrastructure, CESS enables data privacy and sovereignty with a focus on AI Agent applications and frameworks.

Portfolio highlights

• Sidus Heroes — gaming company
• Zombie Worldz — Zombie World Z is a metaverse combining VR on the BSC, upgraded and developed based on a successful and established Zombie Idle Defense.
• CryptoVsZombie — CryptoVsZombie is the ultimate crypto tower defence in which players are required to multitask in both offensive and defensive modes.

Portfolio highlights

• LiquidOps — LiquidOps is a lending and borrowing protocol that providers users the ability to earn interest on their Arweave and AO assets. As well as borrowers the ability to use that lent liquidity in various decentralised applications.
• RiskLayer — RiskLayer is an economic security middleware for DeFi and providing services and validating Creating positive feedback loops.
• GoPlus Security — GoPlus offers holistic AI and Web3 security. Leveraging AI-powered audits and APIs, we safeguard assets and operations across the blockchain and AI landscapes.

Portfolio highlights

• Polygen — Polygen provides a breath of fresh air in the world of blockchain launchpads. Current solutions all foster innovation on a specific blockchain, but they also look and operate the same. Fueling innovation in this industry requires the removal of all intermediaries and gatekeepers. Additionally, there is a need for more transparency, automatedprocesses, and post-launch support.
• Planet Sandbox — Planet Sandbox is the third-person NFT sandbox game that powers players with limitless building tools to customize their own worlds and design game modes. It allows players to build and own arenas to fight other players in different game modes using their own NFT weapons and accessories.
• Ignite Tournaments — Ready to take your mobile games to the next level? Join Ignite Tournaments and compete in real money esports tournaments. Download our app now and win big!

Portfolio highlights

• Wicrypt — Wicrypt is a dynamic organization that consistently allows its users to get paid by sharing their Wi-Fi.
• Gamic — Gamic is a community communication/collaboration app for gamers, creators, and web3 enthusiasts.The platform combines the advantages of blockchain technology with the conventional web2 community setup, creating a seamless environment where users can interact and enjoy the benefits of web3 advancements. This simplifies the process for web2communities to access and leverage the latest blockchain technology innovations, eliminating the need to navigate across various platforms.Today, the user experience is poor for online communities trying to engage with Web3 products and services because users are required to jump across different platforms. Sharing, trading, or managing Web3 assets on most traditional communication and social apps is hard. Addressing this is crucial because Web3 access means financial freedom and opportunity for many all around the world, especially in Africa. Gamic’s central mission is to encourage blockchain adoption as a means to improve the socio-economic opportunities available to global communities. We enable users to communicate and operate in the same place, with increased security and better monetisation opportunities.
• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.

Portfolio highlights

• Spicenet — Spicenet enables universal access to the top DeFi venues across all networks, creating better financial outcomes for all.
• Real Finance — Real Finance is driven by the mission to revolutionize the financial landscape by integrating real-world assets with blockchain technology, creating a more transparent, secure, and efficient ecosystem that bridges traditional finance with decentralized innovation, enhances asset liquidity, and unlocks new opportunities for global investors.
• WorkQuest — About WorkQuest WorkQuest is a decentralized employment and workforce automation protocol enabling employers and workers to collaborate through smart contracts, stablecoin payments, AI matching engines, and on-chain reputation scoring. The platform transforms global employment into a transparent, verifiable, and borderless digital labor economy.

Portfolio highlights

• BullPerks — BullPerks is a community of like-minded individuals who want to leverage their power and invest together in the best projects on equal terms with VCs.
• Hashflow — Tight spreads. Zero slippage. MEV-resistant.
• Joystream — Joystream is a block chain-based, decentralized video platform.

Portfolio highlights

• PERL.eco — The Planetary Ecosystem Registration Ledger will be a dedicated blockchain for real-world ecological assets through tokenizing carbon credits and biodiversity, NFTs and decentralised (DeFi) rewards.
• Meter.io — Meter.io is a base layer hybrid consensus protocol built to address the volatility, scaling and interoperability problems in the existing cryptocurrencies.
• Injective — Explore Injective: the high-performance blockchain powering decentralized finance, governance, and next-gen Web3 apps with unmatched speed and scale.

Portfolio highlights

• Rise Of Defenders — Rise of Defenders is a very interesting Metaverse NFT game, you can use your creativity and tactical thinking to become an excellent player and receive extremely attractive rewards.
• Amyl Therapeutics — Amyl Therapeutics is a preclinical stage biotechnology company. Amyl Therapeutics uses a novel mechanism to bind to the amyloid fold of toxic protein aggregates of various types, including antibody light chain (AL) or transthyretin (TTR) aggregates, which accumulate in peripheral organs to cause systemic amyloidosis diseases, but also amyloid-β(Aβ), Tau, and α-synuclein aggregates, which accumulate in the brain to cause Alzheimer's and Parkinson's diseases.

Portfolio highlights

• Elusiv — Elusiv offers compliance in mind with next-generation privacy solutions for a better Web3.
• TipLink — TipLink helps send crypto with a link. Someone with crypto can create a account and send that link to anyone over any platform. It’s like buying a gift card, connect the client's crypto wallet of choice and create a account by depositing how much they want to send.
• Blueberry Protocol — Access premium DeFi opportunities, tokenized yield strategies, and comprehensive tools for the Hyperevm onchain ecosystem.

Portfolio highlights

• BRKT — Join the fun on BRKT! Make predictions on sports, pop culture, and more!
• Gata — Gata uses data technology to develop superintelligence and to ensure its alignment with human objectives.
• Algebra.Finance — Algebra.Finance is the Financial Services.

Portfolio highlights

• Altcoinist — Altcoinist is an interoperable community gating infrastructure that transforms private communities into vibrant on-chain economies by bringing cutting-edge token gating, community staking pools, and enabling new revenue sources for creators and communities.

Portfolio highlights

• Crowdz — Make accounts receivables a thing of the past with a competitive invoice auction for selling your invoices with invoice financing
• Glamplus — Glamplus is a SAAS-enabled beauty marketplace for salons and spas in the SMB segment. Glamplus customized to suit salon,s needs. Glamplus offers Hassle-free digital appointment tracking, invoicing, customer engagement, revenue management & much more.
• Klaar — Klaar eliminates the stress and bias of performance management with timely AI-powered insights that help teams identify areas for improvement, make data-driven decisions, and ultimately drive better performance & careers.

Portfolio highlights

• Highstreet — Highstreet is a commerce-centric metaverse accessible on browsers and native PC VR. With veterans from VR, Defi, fine art, and hype markets, the mission of Highstreet is to bridge the gap between reality and the digital world and redefine how financial products should be consumed and sold on the market. Players are able to form parties to explore avast new world on the Highstreet interface, own and expand their virtual reality estates, and buy tokenized products from their favorite brands.
• Nyan Heroes — Nyan Heroes is an immersive NFT based shooter of futuristic revolutions, cats in robots, evil corporations.
• Hexagon Wireless — Hexagon Wireless is a provider of decentralized wireless technology.

Portfolio highlights

• Pixelverse — Pixelverse is a blockchain-based, pixelated P2E game.
• Mavryk Dynamics — Mavryk Dynamics simplifies trading real-world assets (RWA) and using decentralized finance (DeFi).
• Swarm Network — Swarm Network is a decentralized network for owning, controlling, and monetizing AI agents.

Portfolio highlights

• Ignite Tournaments — Ready to take your mobile games to the next level? Join Ignite Tournaments and compete in real money esports tournaments. Download our app now and win big!