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Top 15 Medical VC (Venture Capital) Funds in South Africa in May 2026

A list of 15 VC (Venture Capital) funds that invest in Medical startups based in South africa. We rank investors based on the number of investments they made in Medical companies from South africa. We update this investor list every month.

Top 15 Medical VC (Venture Capital) Funds in South Africa in May 2026

Investor Medical South Africa investments
54 Collective 2
HAVAÍC 2
ASISA Enterprise Development Fund 1
WZ Capital 1
Ardent Capital 1
Enza Capital 1
Growth Grid Venture Capital Partners 1
PayPal 1
i-Cubed Capital 1
Jozi Angels 1
PUSH Ventures 1
AngelHub Ventures 1
AAIC Holdings 1
Goodwater Capital 1
JPMorgan Chase & Co. 1

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54 Collective
VC Fund · Johannesburg, NA - South Africa, South Africa

Building and scaling African tech startups with catalytic capital, value-add support and our global network.

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Investment focus

  • Health Care, Information Technology, FinTech
  • Seed, Pre-Seed, Funding Round
  • Kenya, Nigeria, South Africa

Portfolio highlights

  • Billboxx — Manage payables, receivables, financing and banking in one platform.
  • mTek — mTek is a digital online insurance platform that provides an entirely paperless ecosystem for the insurance industry.
  • REasy — Top up locally, pay suppliers globally, and manage international shipments with REasy. Fast, secure, and designed for African businesses expanding worldwide.
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HAVAÍC
VC Fund · Cape Town, NA - South Africa, South Africa

HAVAÍC is an investment and advisory firm that specialises in early-stage, high-growth African businesses with proven concepts and global prospects, offering investment opportunities to sophisticated investors and international venture capital companies with an interest in Africa. As a complementary offering, HAVAÍC provides corporate advisory andcapital raising services to emerging, internationally scalable businesses.

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Investment focus

  • Software, Health Care, FinTech
  • Seed, Funding Round, Series A
  • South Africa, United States, Kenya

Portfolio highlights

  • NjiaPay — Payments-as-a-Service platform that will streamline your operations and elevate your online payments across the African continent.
  • Talk360 — Talk360 is an easy-to-use calling app that helps people make affordable international calls to any mobile and landline number. They believe that reliable communication and digital services must be affordable and accessible to everyone, regardless of someone's background. Especially people in emerging countries in Africa, who often need theseservices the most, do not always have the necessary banking possibilities. To bridge this distance, Talk360 will launch the world's first single checkout platform for Africa. This platform will combine all locally available payment methods and currencies across Africa, together with over 1.25 million cash points of sales, and will eventually be available to other companies as well. This means that 500 million Africans will be able to purchase digital services they never had access to before.
  • Right Now Response — The future of repairs starts soon. Counting down to smarter tracking in 2025! There are perks to working 24/7, 365 days a year... Like launching the future of repairs ahead of schedule!
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ASISA Enterprise Development Fund
VC Fund

ASISA Enterprise Development Fund

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Investment focus

  • Medical, E-Commerce, Health Care
  • Funding Round
  • South Africa

Portfolio highlights

  • RecoMed — Find the best doctors and dentists. Search by location or by speciality, and find the right doctor for you.
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WZ Capital
VC Fund

WZ Capital is a boutique venture capital firm investing in early-stage tech startups.

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Investment focus

  • Medical, Wellness, Health Care
  • Pre-Seed
  • South Africa

Portfolio highlights

  • Contro — Weight Loss TreatmentHealth Coach Support
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Ardent Capital
VC Fund · Bangkok, Krung Thep, Thailand · 7 investments in the past 12 months

Leading Venture Capital & Builder in Southeast Asia | Experts in E-Commerce, B2B, B2C, Fulfilment Startups | Seed, Series A Funding

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Investment focus

  • E-Commerce, Internet, Software
  • Seed, Pre-Seed, Series A
  • Nigeria, Indonesia, Thailand

Portfolio highlights

  • Laborhack — LaborHack offers a select network of tested and certified carpenters, plumbers, electricians, masons, welders, and other tradespeople. It provides cleaning, plumbing, electrical, and HVAC services.
  • Trade Lenda — With Trade Lenda, get quick finance in Nigeria without collateral.
  • Feather Africa — Feather Africa provides money transaction services, such as enabling users to send and receive money from anyone using the application. It offers withdrawals of cash without ATM cards by sending money to the nearest cash vendors.
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Enza Capital
VC Fund · Nairobi, Nairobi Area, Kenya

Venture investor in high-growth Founders and Teams using technology to solve large and meaningful problems across Africa

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Investment focus

  • Financial Services, Finance, E-Commerce
  • Seed, Funding Round, Series A
  • Kenya, Nigeria, South Africa

Portfolio highlights

  • Yakeey — Yakeey is an end-to-end transactional marketplace that radically simplifies the experience of buying, selling and renting real estate.We leverage on data and technology to connect all real estate market players through a state of the art platform, create a chain of trust and powerful network effects and accelerate transactions.Yakeey is builton a community of real estate advisors, YakeeyPRO, to deliver a continuous professional and tailored service at every step of the transaction.
  • Hub2.Io — Welcome to HUB2, the leading FINTECH startup in interoperability and payment infrastructure in Francophone Africa. We are proud to work with all financial industry players in Africa who need stable and high-performing infrastructure, and contribute to their success.
  • Affinity — Join over 125,000 who trust the Affinity mobile app to manage their banking needs, from savings to payments, as well as instant loans
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Growth Grid Venture Capital Partners
VC Fund

Growth Grid Venture Capital Partners

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Investment focus

  • Medical, Software, E-Commerce
  • Funding Round
  • South Africa

Portfolio highlights

  • RecoMed — Find the best doctors and dentists. Search by location or by speciality, and find the right doctor for you.
  • Digital Cabinet — Digital Cabinet makes your business paperless. Security is the topmost priority for the Digital Cabinet, so save time and money with the Digital Cabinet.
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PayPal
VC Fund · San Jose, California, United States

PayPal has remained at the forefront of the digital payment revolution for more than 20 years. By leveraging technology to make financial services and commerce more convenient, affordable, and secure, the PayPal platform is empowering more than 375 million consumers and merchants in more than 200 markets to join and thrive in the global economy.

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Investment focus

  • Financial Services, FinTech, Marketplace
  • Seed, Grant, Funding Round
  • United States, Ireland, Sweden

Portfolio highlights

  • Fordefi — The MPC wallet platform and Web3 gateway from Fordefi allow institutions to connect to dApps across multiple chains while keeping digital assets secure. Fordefi is the first institutional MPC wallet and security platform designed for decentralised finance. It provides MPC key management, self-service DeFi policy controls, time-of-transaction smartcontract insights, transaction simulation, and risk alerts.
  • Padiepal — Discover the Future of Digital Finance with Padiepal Transforming Digital Finance At Padiepal, we're on a mission to redefine the future of digital finance. With an ever-growing range of innovative services, we cater to the needs of individuals, businesses, and global merchants alike. Our objective is to provide seamless transactions andfinancial solutions that meet the demands of today's fast-paced digital world.Comprehensive Services for Everyone Our offerings are designed to empower users to manage their finances effectively. From dollar virtual accounts to international money transfers, we have services that enhance the user experience. Individuals can enjoy straightforward payment solutions, while businesses can utilize our robust tools to expand their operations globally. By combining technology with financial expertise, Padiepal facilitates smart financial decisions for everyone.Why Choose Padiepal? With a commitment to security and transparency, Padiepal is a trustworthy partner in your financial journey. Our user-friendly interface simplifies engaging with digital finance, making it accessible to all. Moreover, we continuously innovate and adapt our services to remain at the forefront of digital finance trends. Whether you’re a seasoned merchant or just starting your financial journey, Padiepal stands ready to support your goals.
  • CoPilot — CoPilot is pioneering Assisted Commerce for big-ticket purchases – starting with cars. You are the one spending the money - shouldn't you have an expert on your side? We founded CoPilot to make that a reality. For the average car buyer, who is not a car expert or enthusiast, car shopping can be a time consuming, frustrating process that leavespeople feeling alone and disadvantaged. CoPilot is changing this dynamic. Like a trusted friend who is knowledgeable about cars, knows where to look and what to buy, CoPilot provides car shoppers with an expert partner who empowers them to discover the perfect car at the best possible price with ease and confidence.
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i-Cubed Capital
VC Fund · Johannesburg, NA - South Africa, South Africa

i-Cubed Capital provide a bouquet of funds for clients, ranging from unit trusts to investment funds for retiremen, including savings plans with tax incentives.i-Cubed provide a bouquet of funds for clients, ranging from unit trusts to investment funds for retirement, including savings plans with tax incentives. We assess fund managerperformances by reviewing fact sheets and provide our clients with a variety of options to meet their investment objectives.

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Investment focus

  • Medical, Wellness, Health Care
  • Pre-Seed
  • South Africa

Portfolio highlights

  • Contro — Weight Loss TreatmentHealth Coach Support
  • Yebo Fresh — Yebofresh is a new online shopping service, delivering popular groceries straight into areas that are generally unserved by most formal retailers. Our unique business model and partnerships with manufacturers allow us to deliver top quality products and A-brands at extremely competitive prices. Yebofresh serves Imizamo Yethu, Langa, Khayelitsha,Mfuleni and Gugulethu and following recent seed funding, is rapidly expanding across the greater Cape Town area.
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Jozi Angels
VC Fund · Johannesburg, NA - South Africa, South Africa

Jozi Angels is an angel network based in Johannesburg, South Africa. We exist to grow the startup ecosystem and facilitate the growth of innovative startups.

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Investment focus

  • B2B, Medical, Wellness
  • Pre-Seed
  • South Africa

Portfolio highlights

  • Jobox — Jobox is a student recruitment platform, built to connect employers, students and graduate career offices. Our focus is to improve graduate employability by ensuring all students have the skills they need to enter, stay in, and progress in the world of work.Jobox’s ecosystem provides employers with access to the best diverse & youthfultalent, students with more employment opportunities and universities with data-driven insights aimed at driving graduate employability forward.
  • Contro — Weight Loss TreatmentHealth Coach Support
  • TUNL — Ship globally with ease. TUNL offers affordable, transparent international shipping built for South African brands. Up to 91% cheaper. No surprises.
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PUSH Ventures
VC Fund · Vienna, Wien, Austria · 3 investments in the past 12 months

We are an early-stage Venture Capital Firm investing in outstanding teams with convincing products and high growth potential.

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Investment focus

  • Software, Apps, Health Care
  • Seed, Funding Round, Series A
  • Austria, United States, Germany

Portfolio highlights

  • FERNRIDE — Fernride enables automated, sustainable logistics by combining the skills of remote drivers with autonomous technologies.
  • Valutico — Valutico is the world‘s leading provider of web-based company valuation tools.Started in 2014 by a team of enthusiastic Corporate Finance professionals and web developers, the concept was born out of frustration with the status-quo in Corporate Finance practice: That professional company valuations used to be the domain of only the mostsophisticated of investors.At Valutico, it has been their mission from the outset to offer cutting-edge valuation tools to a much wider audience. Today they empower everybody to perform company valuations that meet and exceed the standards of even the leading investment banks and advisory firms.The company today is headquartered in Vienna/Austria and has an additional office in Frankfurt/Germany.
  • Ohana — Ohana helps you to protect your child in the digital world. Limit screentime, get insights & guidance, block apps & websites and filter inappropriate content.
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AngelHub Ventures
VC Fund · Stellenbosch, NA - South Africa, South Africa

Operating out of Stellenbosch in South Africa and backed by two family offices Angelhub Ventures's team is passionate about early stage investments in (South) Africa. Being entrepreneurial ourselves, we thoroughly understand the challenges and changes our founders face – which is why we back them in any way we can. Most importantly, we believein building great businesses and we are in it for the long haul.

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Investment focus

  • Software, Information Technology, Education
  • Seed, Series A
  • South Africa, Mexico, Colombia

Portfolio highlights

  • Syscap — Syscap is a financial technology company that offers cutting-edge solutions to financial institutions to have a better administration and management of their funding sources. It connects the leaders of financial and real estate institutions with their funders. For institutions, the company ensures the optimization of their funding source managementprocesses, but also the strengthening of the relationship with their funders. To funders, Syscap guarantees the transparency and timely monitoring of its funds for the safety and growth of its resources.
  • Godochurch — GoDoChurch is a cloud-based church administration software which is designed to assist Christian churches and ministries with managing members, Sunday services, events, communications, and more. The system is made up of a base package, covering messaging, news, ministries, lists, church roles, services, events, and growth paths, with additionalmodules for managing follow-ups, groups, and Kids church.
  • Velocity — Velocity is a micro fulfillment dark store that delivers through digital channels.
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AAIC Holdings
VC Fund · Singapore, Central Region, Singapore

AAIC Holdingsis engages in nurturing investments in emerging countries, consulting and M&A, management outsourcing and human capital.

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Investment focus

  • Health Care, Medical, Apps
  • Seed, Series A, Funding Round
  • Togo, Nigeria, South Africa

Portfolio highlights

  • Gozem — Gozem is a transport technology platform for Francophone West and Central Africa.
  • CrowdForce — We empower businesses to drive mass adoption of digital, and financial services to underserved population in their communities.
  • RelianceHMO — RelianceHMO is solving this problem by providing affordable and reliable insurance packages for the average African. Reliance makes health insurance in Africa cheaper and easier to access by combining Telemedicine with data science.
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Goodwater Capital
VC Fund · Burlingame, California, United States · 67 investments in the past 12 months

Goodwater empowers exceptional entrepreneurs everywhere to change the world for the better. They believe consumer technology is a force on earth, shaping culture and transforming the global economy at unprecedented speed and scale. They invest in promising entrepreneurs to solve pressing problems. As a combined force, Goodwater companies are aglobal force for change, poised to measurably improve billions of lives.

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Investment focus

  • FinTech, Financial Services, E-Commerce
  • Seed, Series A, Series B
  • United States, India, South Korea

Portfolio highlights

  • Vendah — Social commerce platform democratizing the e-commerce in LATAM through local entrepreneurs
  • Zepto — India's fastest grocery delivery service.
  • TANGGapp — Send money to the Philippines with the best exchange rates! Money transfers are received in minutes. Get full transparency on your transaction - no FX markups or secret costs. Download TANGapp today and get started!
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JPMorgan Chase & Co.
VC Fund · New York, New York, United States · 2 investments in the past 12 months

JPMorgan Chase & Co. provides innovative financial solutions for consumers, small businesses, corporations, governments, and institutions. The firm is serving customers, helping small businesses, or putting its skills to work with partners, they strive to identify issues and propose solutions that will propel the future and strengthen both itsclients and communities.

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Investment focus

  • FinTech, Financial Services, Enterprise Software
  • Debt Financing, Seed, Grant
  • United States, Brazil, United Kingdom

Portfolio highlights

  • CoreWeave — CoreWeave provides flexible compute services and products to empower innovators. The company provides GPU accelerated compute solutions to the CGI and machine learning industries. Backed by quality hardware and systems management infrastructure, CoreWeave is built to help clients scale and adapt to evolving compute requirements at industry leadingeconomics.
  • 10X Banking — Put the world's most powerful and comprehensive cloud native banking platform at the core of your bank.
  • InCorp Chain — Bridging Corporates Adoption Towards Crypto Through $ICNX
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