Top 50 Medical Device Startup Investors in Japan (July 2026)

Portfolio highlights

• CastBio — Castbio specializes in antibody-drug conjugate-based drug discovery research and development. Along with medications, it also creates research reagents, medical equipment, in vitro diagnostic items, and offers drug discovery consulting.
• 3DC — 3DC develops and manufactures a new carbon material, graphene meso sponge (GMS), for electrodes in next-generation batteries, capacitors, fuel cells and other energy storage and generation devices.
• Formas.AI — Formas.AI is a multi-modal, AI-powered design platform specifically built for architects, designers, and educators to generate and visualize creative architectural concepts.

Portfolio highlights

• NovAccel — NovAccel operates as a deep tech company, ensure a stable supply of medical radioisotopes.
• Sonire Therapeutics — SONIRE Therapeutics Inc. (SONIRE) is working on a next-generation high-intensity focused ultrasound (HIFU) therapy system that will employ acoustic engineering (ultrasound) technologies developed through cutting-edge academic research. SONIRE has been working on a next-generation high-intensity focused ultrasound (HIFU) treatment system as a noveltherapeutic modality with the goal of giving cancer patients and their families a new future.
• Neusignal Therapeutics — Neusignal Therapeutics is a medical company that develops therapeutic medicines for dementia and psychiatric illnesses.

Portfolio highlights

• ADiXi — Adixi is a tech-driven business that supports the idea that people and technology may work together. It strives to open doors by utilizing cutting-edge technology, such as artificial intelligence, to promote long-term, sustainable corporate and societal progress.
• Diggle — DIGGLE is a service that provides fundamental management accounting management on the cloud called fraud management. It is possible to reduce the mistakes and man-hours of the fraud management task and easily carry out the fraud management task even if it is not an expert in finance or accounting.DIGGLE covers budget creation work and budgetrecord comparison work, especially in the foreman management work. In the budget creation work, the KPI and the budget are automatically created by inputting the target numerical value to the preset parameters utilizing the budget generator function, while the forecast contrasting work is made up of the financial information, non-financial information It is easy to calculate by simply entering the numerical value, and it is possible to carry out calculation of the forecast contrast.
• Luxna Biotech — Luxana Biotech is established to contribute to medical treatment for suffering patients, .

Portfolio highlights

• Menou — MENOU specializes in AI technology and sensing technology. It features a graphical image identification modeler software.
• Space BD — Space BD aims to become a one-stop shop to respond to all issues related to industrialization of space, and alleviate the work of businesses that are developing new technologies.
• Neusignal Therapeutics — Neusignal Therapeutics is a medical company that develops therapeutic medicines for dementia and psychiatric illnesses.

Portfolio highlights

• LQUOM — QWAVE offers cryptography communication technology.
• Direava — Direava is a medical device company that manufactures, sells, leases, and maintains medical equipments along with consulting services.
• Zerodoor HD — Zerodoor HD specializes in digital transformation in constructing industry.

Portfolio highlights

• CaTe —
• EISHIN — EISHIN is a technology company that specializes in pet tech business, recruitment consulting, website creation, and development services.
• Yokohama Vanilla — Yokohama Vanilla is a Company which operates Yokohama-based gift sweets brand.

Portfolio highlights

• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.
• TXP Medical — TXP Medical build a next-generation medical system through acute care.
• Startbahn — Startbahn develops Startrail, a sustainable and scalable blockchain infrastructure that assures the reliability, authenticity, and traceability of artworks.

Portfolio highlights

• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.
• Global Trust Networks — Global Trust Networks is a company that helps foreigners to live in Japan
• Fabric Tokyo — FABRIC TOKYO is a Japanese startup provides a direct-to-consumer custom-made apparel brand. (former-company name Lifestyle Design Co., Ltd.). It enables customers to save their sizes, idea fabrics, and favorite designs, allowing them to make their original clothing later.FABRIC TOKYO was founded in 2012 by Yuichiro Mori and is based in Tokyo,Japan.

Portfolio highlights

• CaTe —
• FunPep — FunPep is an Industry-university collaboration bioventure company.
• NEXT NEW WORLD — NEXT NEW WORLD develops and manufactures natural products with low impact on the environment. It uses sustainable Japanese silk to manufacture apparel and cosmetic products.

Portfolio highlights

• F.MED — F.MED is a manufacturing company that designs and develops robotic microsurgical devices for the healthcare industry.
• Varinos — Varinos is a clinical laboratory contract analysis company that is a partner of medical institutions. Varinos provides genomic testing development and contract analysis services using the latest technology, the next-generation sequencer.
• ElevationSpace — ElevationSpace offers high quality & well equipped workspaces giving tenants a nurturing environment .

Portfolio highlights

• JiMED — JiMED designs & develops AI based brain-computer interface for implant in ALS patients to improve communication.
• Grafenary — Graphenary creates unique graphene optical devices using graphene materials with a variety of remarkable features.
• Neusignal Therapeutics — Neusignal Therapeutics is a medical company that develops therapeutic medicines for dementia and psychiatric illnesses.

Portfolio highlights

• Issin — Issin manufactures bath mats that can measure weight and automatically record daily weight changes on your smartphone.
• RoboTruck — RoboTruck develops autonomous driving technologies for huge trucks, as well as practical applications.
• Leading Mark — Leading Mark, a rising human resources startup in Japan. Leading Mark is branching out into mid-career and international hiring. It currently has a one-man team in China working to bring the top Japanese-speaking Chinese students to domestic companies. He also touts his startup’s focus on the average job seeker. “We want to make sure that the usersget the info that he or she needs the most,” he says. Large scale, legacy players can sometimes prioritize the needs of the hiring company, and their commission, over the needs of applicants themselves. This leads to frustration and short-circuited careers.

Portfolio highlights

• Ripcord — Ripcord is a robotics company that combines hardware and software robotics via an integrated SaaS offering. Its focus is on smart robotics digitization, smart content management with AI, and helping enable RPA and business processes.Ripcord is based in Hayward, California, and is backed by leading investors Kleiner Perkins Caufield & Byers,Google Ventures, Lux Ventures, Legend Star, and Apple Co-Founder Steve Wozniak.
• Rapidus — Rapidus is an Electronic component research, development, design, production, and sales that includes semiconductor elements and integrated circuits. Environmentally friendly, energy-saving semiconductors and semiconductor manufacturing technology are being researched and developed. Human resource development and training for the semiconductorsector.
• VALANX Biotech — VALANX Biotech is a site-specific protein conjugation platform to enable fast and cost efficient protein-drug-conjugates development.

Portfolio highlights

• Molmir — Molmir is a biotech company that conducts research and develops treatments for intractable diseases based on sensing technology.
• EUV Photon — EUV Photon is an irradiation services company that conducts processing, evaluation, and measurement of materials for EUV lights.
• Restore Vision — Restore Vision is a startup based in Japan aiming to develop a visual restoration gene therapy.

Portfolio highlights

• Triorb — Triorb is a technology company that specializes in robot mobility development with the help of software and hardware solutions.
• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.
• Solaris — Solaris commercializes, manufactures, and sells soft robotics using pneumatic artificial muscles. Solaris was founded in 2017 and was headquartered in Tokyo, Japan.

Portfolio highlights

• Yondemy — Yondemy is an online platform for children reading books.
• Yokohama Vanilla — Yokohama Vanilla is a Company which operates Yokohama-based gift sweets brand.
• Zeal Boxing Fitness — Zeal Boxing Fitness combines power of sports with the power of technology to provide a service that allows to enjoy fitness.

Portfolio highlights

• MW — MW is a smart home solution company that develops smart residential physical AI, robotics, and home design services.
• InsightX — InsightX is a technology platform focused on empowering businesses by simplifying complex processes and enabling smarter, more personalized user experiences.
• Neusignal Therapeutics — Neusignal Therapeutics is a medical company that develops therapeutic medicines for dementia and psychiatric illnesses.

Portfolio highlights

• LQUOM — QWAVE offers cryptography communication technology.
• FullDepth — FullDepth is a drone development company.
• Physiologas Technologies — Physiologas Technologies is a manufacturing company that designs and develops medical equipment for the healthcare industry.

Portfolio highlights

• BiPSEE — BiPSEE is a medical XR company that provides treatment support for children for the purpose of nurturing a sense of self-efficacy. They also deploy AR and VR animation with one button dentistry and medicine, whether outpatient or hospitalized in various situations your child's anxiety and pain relieve. It aims to reduce anxiety and pain inchildren in a wide range of medical fields such as dentistry, pediatrics, and dermatology.BiPSEE is abs ed in Tokyo, Japan.
• SEQUENTIAL — 5,971 Followers, 1,054 Following, 268 Posts - See Instagram photos and videos from Sequential Skin (@sequential.skin)
• ALT Sports Data — Real Time Alternative Sports Betting Data.

Portfolio highlights

• NovAccel — NovAccel operates as a deep tech company, ensure a stable supply of medical radioisotopes.
• AstroX — AstroX is a private space startup company that develops satellite launch vehicles for space development. It utilizes the rockoon method for developing launch vehicles and small rockets to help clients easily use space.
• Sonire Therapeutics — SONIRE Therapeutics Inc. (SONIRE) is working on a next-generation high-intensity focused ultrasound (HIFU) therapy system that will employ acoustic engineering (ultrasound) technologies developed through cutting-edge academic research. SONIRE has been working on a next-generation high-intensity focused ultrasound (HIFU) treatment system as a noveltherapeutic modality with the goal of giving cancer patients and their families a new future.

Portfolio highlights

• CELLORB — CELLORB provides player management, sports event planning, and event management services.
• L&F — L&F is a real estate company that develops rental portals and tools for vacant houses, family trusts, and rental property management.
• Illumi Medical — Illumi Medical is a manufacturing company that produces medical equipment and devices for the healthcare sector.

Portfolio highlights

• Tacoms — CAMEL is a service that allows you to easily manage orders from multiple food delivery / takeout services on a single tablet.
• Any Style —
• Smile Robotics — Smile Robotics provides Service Robots in Japan.

Portfolio highlights

• ANSeen — ANSeeN Inc. - X-ray COLOR Imaging
• GAIA BioMedicine — GAIA BioMedicine Inc., a spin-out venture from Kyushu University founded on 2015, is a technology-driven biopharmaceutical company focusing on cellular therapies and immunotherapies mainly for intractable malignancies.
• Jiksak Bioengineering — Jiksak Bioengineering is a biotechnology company. Jiksak Bioengineering provide an efficient screening service using a three-dimensional cell tissue "Nerve Organoid". We will mainly develop screening technologies specifically for neurodegenerative diseases and search for drugs that are effective for amyotrophic lateral sclerosis (ALS).

Portfolio highlights

• Imiron — Imiron the process and tools used for modeling mathematical behavior in order to comprehend its fundamentals.
• Dioseve — Dioseve is providing novel possibilities for all life.
• BEAM Technologies — BEAM Technologies, focuses on developing optical semiconductor devices using special light to offer clean solutions to ecosystem-related problems.

Portfolio highlights

• BitBiome — BitBiome is a microbiome analysis company that aims to discover and understand disease-linked microorganisms. Its, single-cell whole-genome analysis platform specifically targets microbes and can be used on uncultured, raw samples, providing unprecedented strain-level quantitative and functional insights.THe company was founded in 2018 and isbased in Japan.
• TopoLogic — TopoLogic designs and manufactures heat flow sensors, thermoelectric conversion devices, and topological and novel spintronics materials.
• Global Equipment Services — As a strategic partner to developers of multi-sector products, Averna provides innovative automated testing tool and quality assurance solutions.

Portfolio highlights

• Molmir — Molmir is a biotech company that conducts research and develops treatments for intractable diseases based on sensing technology.
• ASEMtech — ASEMtech is a technology company that specializes in research, development, sales, and leasing of medical equipment via the ASEM method.
• Greenase — greenase is a manufacturer and seller of processed agricultural products.

Portfolio highlights

• Akari Hosho — Akari Hosho provides a group of trusted professionals, including lawyers and judicial scriveners. Akari Hosho provides a guarantee service.
• Black Cat Carnival — Black Cat Carnival Inc. is a communication service development company.
• Pixie Dust Technologies — Pixie Dust Technologies is a developer of computational technologies, including its ultrasonic phased array system with which one can generate force in mid-air; transport things in mid-air without touching anything; target and deliver different sounds from person to person in a crowd; direct guide-dogs; and even apply this in agricultural farming.

Portfolio highlights

• REVORN — REVORN is a fragrance AI and DX research and development company. They develop products such as odor sensors that can respond to odor issues and needs. They provide consultation at a range of levels, from identifying issues to developing solutions.
• Helical Fusion — Helical Fusion is a startup company that aims to commercialize fusion energy using magnetic confinement of high-temperature plasmas.
• Illumi Medical — Illumi Medical is a manufacturing company that produces medical equipment and devices for the healthcare sector.

Portfolio highlights

• SecureNavi — SecureNavi offers automation tools for the information security management system. It reduces conventional analogue operations using excel and word. For inquiries, telephone numbers and physical addresses are available on their website.
• Kokoro Mill — Kokoro Mill is a manufacturing company that designs medical devices to analyze autonomic nervous system activity and arrhythmias.
• NEXTAGE — Nextage is an Agri-tech company that offers wasabi cultivation in a container.

Portfolio highlights

• IVRy — Ivry offers cloud based telephonic answering service.
• Solafune — Solafune is a data science competition platform that leverage satellite and geospatial data.
• H2 — H2 Corporation offers an automation solution called "AI Estimation" for estimating tasks.

Portfolio highlights

• ASEMtech — ASEMtech is a technology company that specializes in research, development, sales, and leasing of medical equipment via the ASEM method.

Portfolio highlights

• 3DC — 3DC develops and manufactures a new carbon material, graphene meso sponge (GMS), for electrodes in next-generation batteries, capacitors, fuel cells and other energy storage and generation devices.
• THE PHAGE — The phage is a medical device company that focuses on developing AI technology to predict postprandial blood glucose levels.
• Mira Robotics — Mira Robotics is a software based company provide services that can robots in various fields.

Portfolio highlights

• MOVeLOT — MOVeLOT is an AI company that provides skeletal platform and robot planning, development, and production services.
• Kisui Tech — Kisui Tech is an agricultural AI robotics company that help farmers for farming.
• LYMPHOGENiX — LYMPHOGENiX is the pioneer company for lymphatic vessels regeneration. Our proprietary technology revitalizes the function of lymphatic vessels, making us experts in treating various health conditions. Our treatment is also great for skin-aging, obesity, Alzheimer's diseases and infertility. We believe in helping our clients improve their vitality and energy, one treatment at a time.

Portfolio highlights

• Unocoin — Unocoin a cryptocurrency exchange in India, offers seamless trading of Bitcoin & other cryptos. With 2M users Since 2013. Join India's trusted crypto platform.
• Kava Labs — Kava is a lightning-fast Layer-1 blockchain that combines the two most used permissionless execution environments into a single, scalable, developer-optimized network.
• Triple W Japan — Triple W develops DFree, the first wearable device for incontinence that can track the progression of bladder movements using a non-invasive ultrasonic sensor. The device will help elderly and disabled people who suffer from incontinence by notifying when they will need to go to the bathroom. DFree is now widely marketed in Asia and Europe and usedin over 500 senior care facilities. Triple W has offices in Japan, France, and the US.

Portfolio highlights

• Neubond — Neubond develops wearable devices for stroke mobility rehabilitation. These devices provide autonomous assistance and therapy during daily activities, integrating rehabilitation into the patient's daily life regardless of their motor capabilities. Neubond's solutions are designed to be intuitive and effective, aiming to improve thequality of life for individuals undergoing rehabilitation.
• Pestalozzi Technology — Pestalozzi Technology is a development and provision of educational products in the fields of physical education and club activities.
• Gel-Coat Biomaterials — Gel-Coat Biomaterials is a biotechnology company that develops innovative bio-based materials and new medical technologies.

Portfolio highlights

• JiMED — JiMED designs & develops AI based brain-computer interface for implant in ALS patients to improve communication.
• LQUOM — QWAVE offers cryptography communication technology.
• Toregem BioPharma — Toregem BioPharma is a startup from Kyoto University that develops a treatment for congenital adentia. Toregem BioPharma is headquartered in Kyoto, Japan.

Portfolio highlights

• CaTe —
• OOYOO — OOYOO Co., Ltd. is a DeepTech venture that combines international entrepreneurial spirit, and a 'Made In Japan' excellence, to bring the latest innovations in clean technology to society for a smarter, cleaner, and more mobile world.
• KG Motors — KG Motors is an automotive firm that manufactures electric vehicles that can be moved comfortably and safely by one person.

Portfolio highlights

• JiMED — JiMED designs & develops AI based brain-computer interface for implant in ALS patients to improve communication.
• Cosomil — Cosomil develops early diagnostic drugs for diseases and provides research and development support to healthcare companies.
• Physiologas Technologies — Physiologas Technologies is a manufacturing company that designs and develops medical equipment for the healthcare industry.

Portfolio highlights

• LIFESCAPES — LIFESCAPES is a research and manufacturer of brain-computer interface equipment.
• Metcela — Cells hold endless possibilities. Through science, we will unlock these potentials and harness them to improve the lives of patients worldwide.
• Hirosaki Lifescience Innovation — Hirosaki Lifescience Innovation is engaged in the development, manufacture, and sale of regenerative medicine products.

Portfolio highlights

• NodeX — We build open-source embedded software and cloud tools to help developers build secure IoT products, simply. By leveraging decentralized identity and h/w root of trust technology, IoT security platform "UNiD" enables developers to automate device management and easily build secure data pipeline between every devices and the cloud.
• Simplex Quantum — Simplex Quantum conducts research and development of AI-based solutions in the healthcare field and operates the SQ-bar service.It also offers the Shinden-kun, a portable device that can analyze the measured electrocardiographic information with AI and detect heartbeat turbulence.It was established on October 3, 2014 and headquartered inTakanawa, Minato-ku.
• Link Therapeutics — Link Therapeutics specializes in developing therapeutic methods for targeting autoantibodies and identifying pathogenic autoantibodies.

Portfolio highlights

• Grafto —
• xCARE — xCARE specializes in the development and commercialization phases of the pharmaceutical and medical device industries.
• Yellow Blue — Yellow Blue develops and operates "Blue One," a next-generation AI translation service designed for professionals.

Portfolio highlights

• Fermelanta — Fermelanta produces rare plant-based ingredients through microbial fermentation. It engineers a cell to build a biosynthetic pathway of target molecules with gene transfer and disruption.
• Atom — Atom is a humanoid robot built platform. Its bipedal, dual-armed robots are designed not just as industrial tools but as collaborators that expand human capability. By combining advanced Physical AI—environmental perception, judgment, and action planning—with robust robotic hardware, Atom is creating adaptive agents capable of working acrossdiverse settings to augment or, where appropriate, replace human labor. The company positions these robots as a next step in societal evolution: a new class of machines that learn and behave in human-like ways to advance productivity, safety, and quality of life.
• Link Therapeutics — Link Therapeutics specializes in developing therapeutic methods for targeting autoantibodies and identifying pathogenic autoantibodies.

Portfolio highlights

• Deja — Modern Rituals & Natural Products from the Ancient Science of Ayurveda
• Enoki Inc — Multiplayer-enabled tools for developers. Enoki has 18 repositories available. Follow their code on GitHub.
• Homethings — Single-use plastic is bonkers. Homethings makes cleaning products that make sense. No more shipping water in plastic bottles. We send non toxic cleaning tabs so that you can refill over and over again using your tap.

Portfolio highlights

• Magnax — Magnax develops yokeless axial flux electric motors for eMobility and Aerospace
• Hyperlight — HyperLight unleashes the potential of integrated photonics by developing a proprietary platform based on thin-film lithium niobate (TFLN)
• India Chip — India Chip is formed to manufacture and designed for a capacity of 20,000 wafers per month and can produce 36 million display driver chips.

Portfolio highlights

• PIMTO — PIMTO Corporation is a technology company that provides digital solutions for location and facility management. Through its PIMT-0 service, it supports airports, stations, commercial facilities, hotels, factories, and public organizations in improving operations, profitability, and customer satisfaction. The company also focuses on addressingsocial challenges such as overtourism, regional revitalization, remote work creation, and improving access to essential services.
• Kakutoku — Nitlon Inc. provides crowdsourcing management services. The company was founded by Seiya Mitsuda on February 02, and is headquartered in Beppu, Japan.
• AlarmBox — AlarmBox develops services that make use of professional knowledge of technology and corporate screening, and changes common sense of risk management of enterprise.

Portfolio highlights

• Akari Hosho — Akari Hosho provides a group of trusted professionals, including lawyers and judicial scriveners. Akari Hosho provides a guarantee service.
• Serendip Consulting — Serendip Consulting refers to business portfolio optimization and provision of effective solutions.The Serendip Group operates not only strategic and financial consulting, but also a business company with a focus on manufacturing. Aiming for further growth of the entire group by restructuring the "business portfolio" based on the know-howof nurturing small and medium-sized businesses cultivated over 10 years since its foundation and investment experience, and "modernizing management" by dispatching professional managers You.
• Monozukuri Business Succession Holdings (JMS) — Monozukuri Business Succession Holdings is a specialized corporate investment subsidiary. The platform modernizes mid-sized manufacturing firms facing generational leadership transitions. Strategic institutional banking partnerships protect public shareholder equity from dilution. After acquisition, the firm installs professional management andautomated factory systems. All operational yields consolidate into the parent organization to drive long-term growth.

Portfolio highlights

• Nealle — Nealle offers business development, business planning and consulting services.
• ACCIONA — At ACCIONA we offer sustainable solutions to the most urgent challenges facing the planet, such as global warming, energy needs and water shortages
• Vena Energy — Vena Group delivers renewable energy, battery, and hydrogen solutions across Asia-Pacific. Explore our green innovations driving the low-carbon transition today

Portfolio highlights

• Ginco — Ginco's goal is to Change the relationship between individuals and assets by making full use of block chain technology. The primary focus of Ginco, its cryptocurrency wallet app, is centered around dApp and the On-Chain function, and the company plans to expand its business in a multifaceted manner while watching trends in the ecosystemdevelopment. In the future, they were told that they have the possibility of developing with DEXs (decentralized exchanges).
• Scohia Pharma — Scohia Pharma is a biotech venture that will have both substantial research and development resources and be nimble enough to make decisions quickly, will strive to improve patient quality of life by providing patients and healthcare professionals with new therapeutic medications for renal, metabolic.
• Arrowsmith — Arrowsmith is committed to unlocking the full potential of bacteriophages to revolutionize the treatment of bacterial infectious diseases. Through transformative science, Arrowsmith strive to create a world free from the pain and fear caused by antimicrobial resistance.

Portfolio highlights

• SOUNDRAW — Your personal AI music generator.
• Inter Holding — Inter delivers solutions for global difficulties using vacuum technology, which uses a particular check valve to maintain a 99.5% vacuum rate.
• Better Place — Better place vision is to create a world in which kind people can continue to be kind, as well as a society in which people can work in their own way without worrying about money.

Portfolio highlights

• A-Wave — A-Wave is a manufacturing company that develops and markets medical devices, pharmaceuticals, computer software, and hardware.
• Quali — Quali is dedicated to developing innovative products and solutions that support microsurgery, with the goal of addressing critical challenges in the medical field and improving patient outcomes and overall quality of life.
• Avisi Technologies — Avisi Technologies is developing a nanotechnology-enabled defense against blindness from glaucoma.