Top 50 Medical Device Startup Investors in Japan (June 2026)

Portfolio highlights

• CastBio — Castbio specializes in antibody-drug conjugate-based drug discovery research and development. Along with medications, it also creates research reagents, medical equipment, in vitro diagnostic items, and offers drug discovery consulting.
• Illumi Medical — Illumi Medical is a manufacturing company that produces medical equipment and devices for the healthcare sector.
• Reborna Biosciences — Reborna Biosciences provides research and development in the field of genetic diseases. The company develops therapeutic options for area of unmet medical needs in genetic rare disease. The company's technology enables low-molecular compounds to target ribonucleic acid. The company provides new disease-modifying drugs for patients sufferingfrom rare genetic diseases including spinal muscular atrophy.

Portfolio highlights

• Diggle — DIGGLE is a service that provides fundamental management accounting management on the cloud called fraud management. It is possible to reduce the mistakes and man-hours of the fraud management task and easily carry out the fraud management task even if it is not an expert in finance or accounting.DIGGLE covers budget creation work and budgetrecord comparison work, especially in the foreman management work. In the budget creation work, the KPI and the budget are automatically created by inputting the target numerical value to the preset parameters utilizing the budget generator function, while the forecast contrasting work is made up of the financial information, non-financial information It is easy to calculate by simply entering the numerical value, and it is possible to carry out calculation of the forecast contrast.
• Fermelanta — Fermelanta produces rare plant-based ingredients through microbial fermentation. It engineers a cell to build a biosynthetic pathway of target molecules with gene transfer and disruption.
• Japan Culture and Technology — Japan Culture and Technology assists artists and craftspeople in expanding their activities by providing IT support.

Portfolio highlights

• Gecipe — Gecipe is a video service for e-sports players.
• Issues — Issues provides development and management of web service issues that solve the problems.
• SecureNavi — SecureNavi offers automation tools for the information security management system. It reduces conventional analogue operations using excel and word. For inquiries, telephone numbers and physical addresses are available on their website.

Portfolio highlights

• Global Vascular —
• Sonire Therapeutics — Sonire Therapeutics provides High-Intensity Focused Ultrasound treatment for cancer.
• Neusignal Therapeutics — Neusignal Therapeutics is a medical company that develops therapeutic medicines for dementia and psychiatric illnesses.

Portfolio highlights

• ImmunoScape — ImmuniScape discovers and develops novel TCR-based therapeutics against solid tumors
• Metcela — Cells hold endless possibilities. Through science, we will unlock these potentials and harness them to improve the lives of patients worldwide.
• Startbahn — Startbahn develops Startrail, a sustainable and scalable blockchain infrastructure that assures the reliability, authenticity, and traceability of artworks.

Portfolio highlights

• Plott — Plott producing youtube animation platform under Vision “Become a Content holder from YouTube”. In August 2019, the company name was changed from Fabo to Plott. Plott, the new company name, is derived from the plot that you make before writing novels, etc., and the idea that “I want to make content all the time” is put in the company name.
• Sharing Energy — Sharing Energy is providing energy supply and energy management services.
• The Chain Museum — The Chain Museum creates a platform for connecting individuals .

Portfolio highlights

• Menou — MENOU specializes in AI technology and sensing technology. It features a graphical image identification modeler software.
• Castee — Castee provides social collaboration services and also helps with a tool for job requests and overseas projects for creators.
• 3S — 3S is a SaaS developer platform that provides and operates 24-hour home nursing care services through technology.

Portfolio highlights

• Issin — Issin manufactures bath mats that can measure weight and automatically record daily weight changes on your smartphone.
• RoboTruck — RoboTruck develops autonomous driving technologies for huge trucks, as well as practical applications.
• Leading Mark — Leading Mark, a rising human resources startup in Japan. Leading Mark is branching out into mid-career and international hiring. It currently has a one-man team in China working to bring the top Japanese-speaking Chinese students to domestic companies. He also touts his startup’s focus on the average job seeker. “We want to make sure that the usersget the info that he or she needs the most,” he says. Large scale, legacy players can sometimes prioritize the needs of the hiring company, and their commission, over the needs of applicants themselves. This leads to frustration and short-circuited careers.

Portfolio highlights

• ElleThermo — elleThermo aims to implement Semiconductor-Sensitised Thermal Cells (STCs), an energy conversion technology that can generate electricity from unused waste heat above room temperature.
• Aeterlink — Aeterlink is a wireless device maker and developer. They applied their technology to fields such as FA, robots, smart houses, and medicine and developed practical level technologies such as elemental technology that can wirelessly supply power.
• Metagen Therapeutics — Metagen Therapeutics is a Drug discovery and medical business company which utilizes microbiome science.

Portfolio highlights

• Logiless — Logiless is a cloud type all-in-one software dedicated to net shop. Since both orders and stocks can be managed together in a logical manner, efficiency of operations can be realized at low cost.
• LUC — LUC is a provider of the AI ​​x experience analysis platform "TERUS," .
• Turing — Turing develops and manufactures fully autonomous vehicles.

Portfolio highlights

• LQUOM — QWAVE offers cryptography communication technology.
• Captain Fresh — Captain Fresh is a freshwater fish and seafood supply chain platform. Captain Fresh is a B2B marketplace leveraging technology to deliver the fastest harvest-to-retail in the industry. The company focuses on aggregating the fragmented retail demand across the country and linking them to the small fishermen and farmers throughout the Indian coast.The company was founded in 2019 and is based in Bengaluru, India.
• Sonire Therapeutics — Sonire Therapeutics provides High-Intensity Focused Ultrasound treatment for cancer.

Portfolio highlights

• ANSeen — ANSeeN Inc. - X-ray COLOR Imaging
• GAIA BioMedicine — GAIA BioMedicine Inc., a spin-out venture from Kyushu University founded on 2015, is a technology-driven biopharmaceutical company focusing on cellular therapies and immunotherapies mainly for intractable malignancies.
• Jiksak Bioengineering — Jiksak Bioengineering is a biotechnology company. Jiksak Bioengineering provide an efficient screening service using a three-dimensional cell tissue "Nerve Organoid". We will mainly develop screening technologies specifically for neurodegenerative diseases and search for drugs that are effective for amyotrophic lateral sclerosis (ALS).

Portfolio highlights

• Ripcord — Ripcord is a robotics company that combines hardware and software robotics via an integrated SaaS offering. Its focus is on smart robotics digitization, smart content management with AI, and helping enable RPA and business processes.Ripcord is based in Hayward, California, and is backed by leading investors Kleiner Perkins Caufield & Byers,Google Ventures, Lux Ventures, Legend Star, and Apple Co-Founder Steve Wozniak.
• Rapidus — Rapidus is an Electronic component research, development, design, production, and sales that includes semiconductor elements and integrated circuits. Environmentally friendly, energy-saving semiconductors and semiconductor manufacturing technology are being researched and developed. Human resource development and training for the semiconductorsector.
• VALANX Biotech — VALANX Biotech is a site-specific protein conjugation platform to enable fast and cost efficient protein-drug-conjugates development.

Portfolio highlights

• LQUOM — QWAVE offers cryptography communication technology.
• FullDepth — FullDepth is a drone development company.
• AZUL Energy — AZUL Energy provides next-generation energy devices.

Portfolio highlights

• Z-Works — "Z-Works Life Engine" is a cloud-type IoT platform. Collect and analyze the data of the terminal equipped with Z-Wave on the cloud, you can browse various data with the smartphone and remotely control the terminal equipped with Z-Wave.
• NovAccel — NovAccel operates as a deep tech company, ensure a stable supply of medical radioisotopes.
• Sonire Therapeutics — Sonire Therapeutics provides High-Intensity Focused Ultrasound treatment for cancer.

Portfolio highlights

• Josan-shes — Josan shes is web start up that offers nursing service to women and babies.
• ACCEL Stars — ACCEL Stars is a fitness and wellness firm that offers sleep diagnosis and examinations like sleep health, hygiene and medical devices.
• Cellid — Cellid developing the waveguide-architecture display module for AR glasses and high-performance spatial recognition software.

Portfolio highlights

• Airato — Airato specializes in the development of radiation therapy using artificial intelligence technology.
• CELLORB — CELLORB provides player management, sports event planning, and event management services.
• Illumi Medical — Illumi Medical is a manufacturing company that produces medical equipment and devices for the healthcare sector.

Portfolio highlights

• Bloomo Securities — Bloomo Investment is a software company that specializes in the development of smart and fun investment apps.
• Spiral.AI — Spiral.AI offers services for large language models, AI language model platform, and customization features for ChatGPT for businesses.
• OWNY — Manage capital, investors and treasury

Portfolio highlights

• F.MED — F.MED is a manufacturing company that designs and develops robotic microsurgical devices for the healthcare industry.
• Triorb — Triorb is a technology company that specializes in robot mobility development with the help of software and hardware solutions.
• ElevationSpace — ElevationSpace offers high quality & well equipped workspaces giving tenants a nurturing environment .

Portfolio highlights

• JiMED — JiMED designs & develops AI based brain-computer interface for implant in ALS patients to improve communication.
• Cosomil — Cosomil develops early diagnostic drugs for diseases and provides research and development support to healthcare companies.
• Horizon Illumination Lab Optics —

Portfolio highlights

• Autify — AI software testing company aimed at solving the challenges associated with automation testing. We are passionate about making software testing faster and easier, empowering companies to release faster and keep their applications stable.
• Nekonome — Nekonome creates a game platform with global character designs, in-game updates, and regular events, providing a personalized gaming experience based on data.
• AVA Intelligence — AVA Intelligence is a Internet service development company.

Portfolio highlights

• LEP —
• SecureNavi — SecureNavi offers automation tools for the information security management system. It reduces conventional analogue operations using excel and word. For inquiries, telephone numbers and physical addresses are available on their website.
• Akari Hosho — Akari Hosho provides a group of trusted professionals, including lawyers and judicial scriveners. Akari Hosho provides a guarantee service.

Portfolio highlights

• Linqmed — Linqmed is a pharmaceutical company that specializes in the research and development of radiopharmaceuticals for cancer treatment.
• Simple Form — Simple Form provides real-time information on all domestic corporations necessary for financial institutions. We will accelerate the time-consuming and labor-intensive research work of corporations and take on the role of new financial underpinnings.
• Japan Culture and Technology — Japan Culture and Technology assists artists and craftspeople in expanding their activities by providing IT support.

Portfolio highlights

• SOUNDRAW — Your personal AI music generator.
• Inter Holding — Inter delivers solutions for global difficulties using vacuum technology, which uses a particular check valve to maintain a 99.5% vacuum rate.
• Better Place — Better place vision is to create a world in which kind people can continue to be kind, as well as a society in which people can work in their own way without worrying about money.

Portfolio highlights

• Alivas — Alivas is a medical company that develops new therapeutic medical devices for refractory constipation. It is a joint venture between Stanford University and the University of Tokyo with the Japan Biodesign program for innovative medical device creation. The company was founded in 2017 and is based in Hongo, Tokyo in Japan.
• SentiAR — SentiAR is digital health, software device company adding a new dimension to clinical practice in interventional procedures. Spun out of Washington University, we are developing the first 3D visualization platform using real-time holography of the patient's anatomy and catheter location, "floating" over the patients, with a goal toprovide the clinician and patient a faster, safer delivery of care.SentiAR’s mission is to transform the experience for both patient and clinician in interventional procedures with a 3D augmented reality platform featuring real-time holographic visualization of the patient’s actual anatomy, “floating” over the patient.The visualization is fully controllable “hands-free” by the clinician, providing an ergonomic breakthrough for the treatment and analysis of cardiac arrhythmias within an interventional catheter lab environment. SentiAR is developing the platform for eventual FDA submission.
• Avisi Technologies — Avisi Technologies is developing a nanotechnology-enabled defense against blindness from glaucoma.

Portfolio highlights

• Emole — Emole is a platform that connects content creators with viewers through short drama content, offering a variety of engaging stories.
• Utoniq — Utoniq service allows them to collect the works of the artists they support digitally in the form of trading cards. Trading cards will be collected as proof of support for the creators. It is a brand-new trading card service that is both enjoyable to collect and enjoyable to exchange. They provide a service lineup in order to continually increasefan engagement. They can make flexible proposals based on the needs of artists, creators, influencers, anime characters, and so on.
• Domuz — Domuz is a firm that wants to utilize technology and design to create a lifestyle that makes potted plants and flowers more comfortable.

Portfolio highlights

• Fivot — Fivot is a financial company that provides venture capital, financing, credit, money lending, and prepaid payment services.
• digzyme — Digzyme is a research and development platform for creating, discovering, and evaluating new enzyme-catalyzed reactions by bioinformatics.
• Zehitomo — Zehitomo is an Japanese online platform that enables user to hire local service professionals, from photographers to personal trainers.

Portfolio highlights

• ACCIONA — At ACCIONA we offer sustainable solutions to the most urgent challenges facing the planet, such as global warming, energy needs and water shortages
• Kyoto Fusioneering — Kyoto Fusioneering is a research & development, design, and manufacture of parts related to fusion reactors.
• Hunter Point Capital — Hunter Point Capital is an independent investment firm seeking to provide innovative capital solutions to alternative asset managers across the globe.

Portfolio highlights

• Letara — Letara operates a space technology platform with the intention to serve a logistics network covering the solar system. The company produces hybrid propulsion engines for small spacecraft, promoting groundbreaking advances in space propulsion with high thrust, safe, and inexpensive propulsion system technology.
• Pragtech — Pragtech develops and operates parking lot service software that helps to eliminate payment congestion and reduce operating costs.
• Metro Weather — Metroweather is a venture from Kyoto University that develops a high-performance Doppler lidar that measures the direction and speed of wind several tens of kilometers away from minute movements of fine particles in the atmosphere. We aim to contribute to the safety of the sky by completing a three-dimensional wind map, which has never beenrealized,based on years of research at the Kyoto University Research Institute for Sustainable Areas.

Portfolio highlights

• LiftBase — LiftBase is revolutionizing the recruiting structure using AI and social data.
• MoonJapan — MoonJapan is an educational impact startup that offers a variety of programs and thorough assistance.
• Nagisa — Nagisa develops smartphone applications to facilitate free group chats, calls, and photo and movie sharing services. It was launched in 2010 by Yoshiyuki Yokoyama and is based in Tokyo, Japan.

Portfolio highlights

• Magnax — Magnax develops yokeless axial flux electric motors for eMobility and Aerospace
• Robocore — Robocore is the leading developer of application for robotic platform.
• India Chip — India Chip is formed to manufacture and designed for a capacity of 20,000 wafers per month and can produce 36 million display driver chips.

Portfolio highlights

• Unocoin — Unocoin a cryptocurrency exchange in India, offers seamless trading of Bitcoin & other cryptos. With 2M users Since 2013. Join India's trusted crypto platform.
• Kava Labs — Kava is a lightning-fast Layer-1 blockchain that combines the two most used permissionless execution environments into a single, scalable, developer-optimized network.
• Triple W Japan — Triple W develops DFree, the first wearable device for incontinence that can track the progression of bladder movements using a non-invasive ultrasonic sensor. The device will help elderly and disabled people who suffer from incontinence by notifying when they will need to go to the bathroom. DFree is now widely marketed in Asia and Europe and usedin over 500 senior care facilities. Triple W has offices in Japan, France, and the US.

Portfolio highlights

• Pestalozzi Technology — Pestalozzi Technology is a development and provision of educational products in the fields of physical education and club activities.
• Gel-Coat Biomaterials — Gel-Coat Biomaterials is a biotechnology company that develops innovative bio-based materials and new medical technologies.
• CoreTissue BioEngineering — CoreTissue BioEngineering is a development of an artificial ligament for reconstruction of the anterior cruciate ligament in Japan.

Portfolio highlights

• QunaSys — Quantum physics is a relatively new field built since the beginning of the 20th century, but we have used MRI (nuclear magnetic resonance equipment) and lasers used for close examinations in hospitals, and semiconductors mounted on computers. Supports the technology that supports the daily life of people.QunaSys was established to bring out thequantum physics that has been active behind the scenes to the front stage, and to make use of quantum properties to realize technologies that could not be achieved with existing technologies.
• Luxna Biotech — Luxana Biotech is established to contribute to medical treatment for suffering patients, .
• Celaid Therapeutics — Celaid Therapeutics specializes in manufacturing and sales of regenerative medicine products utilizing human hematopoietic stem cells.

Portfolio highlights

• 3DC — 3DC develops and manufactures a new carbon material, graphene meso sponge (GMS), for electrodes in next-generation batteries, capacitors, fuel cells and other energy storage and generation devices.
• THE PHAGE — The phage is a medical device company that focuses on developing AI technology to predict postprandial blood glucose levels.
• Mira Robotics — Mira Robotics is a software based company provide services that can robots in various fields.

Portfolio highlights

• CaTe —
• ARCS — ARCS specializes in developing assisted reproductive medical devices using robotics and artificial intelligence technology.
• KG Motors — KG Motors is an automotive firm that manufactures electric vehicles that can be moved comfortably and safely by one person.

Portfolio highlights

• Argos — Argos provides the online insurance medical treatment service.
• Brainbuddy — Brainbuddy specializes in sales support, business growth, recruiting, consulting, and training services.
• Helical Fusion — Helical Fusion is a startup company that aims to commercialize fusion energy using magnetic confinement of high-temperature plasmas.

Portfolio highlights

• Ubitus — As cloud gaming enablers, Ubitus' GPU virtualization, Streaming technology and hybrid cloud deployment can serve different kinds of solutions for Telco, Game companies to quick enter cloud gaming market. Moreover, Ubitus provide Global distribution and New Media content solution for new media studio and fashion brand to help them distribute rich media contents worldwide.
• EMobi — EMoBi is a transportation company that provides freight transport, and electric vehicle services with reservation facilities.
• Global Equipment Services — As a strategic partner to developers of multi-sector products, Averna provides innovative automated testing tool and quality assurance solutions.

Portfolio highlights

• ASEMtech — ASEMtech is a technology company that specializes in research, development, sales, and leasing of medical equipment via the ASEM method.

Portfolio highlights

• Molmir — Molmir is a biotech company that conducts research and develops treatments for intractable diseases based on sensing technology.
• ASEMtech — ASEMtech is a technology company that specializes in research, development, sales, and leasing of medical equipment via the ASEM method.
• Greenase — greenase is a manufacturer and seller of processed agricultural products.

Portfolio highlights

• OptQC — OptQC commercializes cutting-edge optical quantum computing technologies developed by the Furusawa-Endo Laboratory. Because optical quantum computers are more scalable than superconducting and other quantum computing implementations, OptQC's optical quantum computers should reach this scale. They also have benefits like faster processing andreduced power consumption, which makes optical quantum computers a possible long-term pinnacle of quantum technology.
• Triorb — Triorb is a technology company that specializes in robot mobility development with the help of software and hardware solutions.
• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.

Portfolio highlights

• Nexta — Nexta manufactures site, issues such as analog management, personalization of operations & labor shortages are becoming more serious.
• Logo Labo — Logo Labo provides branding and marketing services, including brand development, formulation, IT-based branding and marketing support.
• MUSE — MUSE is a robotics company that provides robotic solutions for retail stores to support in-store operations.

Portfolio highlights

• Paytner — yup is providing services to support freelance people's funding.The freelance population in Japan has been shown to continue to increase in many Chosa. While working styles are diversified, they are not able to respond to the development of the working environment, and they will develop their business to change the situation where problemssuch as funding, credit, sexual harassment, and power harassment are accumulated.
• Akari Hosho — Akari Hosho provides a group of trusted professionals, including lawyers and judicial scriveners. Akari Hosho provides a guarantee service.
• Black Cat Carnival — Black Cat Carnival Inc. is a communication service development company.

Portfolio highlights

• Molmir — Molmir is a biotech company that conducts research and develops treatments for intractable diseases based on sensing technology.
• Photo Electron Soul — Photo electron Soul mission is to innovate the world of "seeing (fine observation)" and "creating (fine processing)" through the development of photocathode electron beam technology.　The photocathode electron beam technology developed by our company will produce next generation electron beams with high performance andversatility (pulse structure, low dispersion, large current). By renewing the electron beam, which is a key device for industrial equipment such as electron microscopes, semiconductor device manufacturing / inspection equipment, and metal 3D printers, it is possible to realize fine observation, fine processing, high throughput, etc. Breakthroughs in a wide range of fields such as science, materials, and electronics.
• Restore Vision — Restore Vision is a startup based in Japan aiming to develop a visual restoration gene therapy.

Portfolio highlights

• LIFESCAPES — LIFESCAPES is a research and manufacturer of brain-computer interface equipment.
• Metcela — Cells hold endless possibilities. Through science, we will unlock these potentials and harness them to improve the lives of patients worldwide.
• Hirosaki Lifescience Innovation — Hirosaki Lifescience Innovation is engaged in the development, manufacture, and sale of regenerative medicine products.

Portfolio highlights

• MOVeLOT — MOVeLOT is an AI company that provides skeletal platform and robot planning, development, and production services.
• Kisui Tech — Kisui Tech is an agricultural AI robotics company that help farmers for farming.
• LYMPHOGENiX — LYMPHOGENiX is the pioneer company for lymphatic vessels regeneration. Our proprietary technology revitalizes the function of lymphatic vessels, making us experts in treating various health conditions. Our treatment is also great for skin-aging, obesity, Alzheimer's diseases and infertility. We believe in helping our clients improve their vitality and energy, one treatment at a time.

Portfolio highlights

• Logomix — Logomix Inc is a mammalian cellular genome architect startup. Logomix proprietary platform, Geno-Writing™, technology integrates large-scale (Mb) human genome-writing technologies and providing genetically architected versatile human cells and/or downsized cells and microbes for drug development and cell & gene therapy area.Majority ofthe cell engineering companies are currently focused on optimization of gene clusters by automatic high throughput system however, Logomix’s Geno-Writing™ provides the required tools for dealing with mammalian or complex genomes. Logomix works with partners by providing new biology-based solutions to co-create business and social values on Geno-Writing™ platform Current Focus Area includes: 1. Human Health & Therapeutics 2. Biomaterials & Chemicals 3. Agriculture & EnvironmentLogomix has 11 ongoing collaborative research partnerships. Currently Logomix is specifically looking for industry partners to address unmet needs in neurodegenerative disease areas.
• CMerTV — CMer TV is a platform that connects advertisers with newspapers, magazines, and specialized media by video
• Link Therapeutics — Link Therapeutics specializes in developing therapeutic methods for targeting autoantibodies and identifying pathogenic autoantibodies.

Portfolio highlights

• YOUTRUST — YOUTRUST is a startup to operate YOUTRUST a referral recruitment platform for side-job change.
• Henry — Henry develops and provides a cloud-based electronic medical record and receipt system for small and medium-sized hospitals.
• Logomix — Logomix Inc is a mammalian cellular genome architect startup. Logomix proprietary platform, Geno-Writing™, technology integrates large-scale (Mb) human genome-writing technologies and providing genetically architected versatile human cells and/or downsized cells and microbes for drug development and cell & gene therapy area.Majority ofthe cell engineering companies are currently focused on optimization of gene clusters by automatic high throughput system however, Logomix’s Geno-Writing™ provides the required tools for dealing with mammalian or complex genomes. Logomix works with partners by providing new biology-based solutions to co-create business and social values on Geno-Writing™ platform Current Focus Area includes: 1. Human Health & Therapeutics 2. Biomaterials & Chemicals 3. Agriculture & EnvironmentLogomix has 11 ongoing collaborative research partnerships. Currently Logomix is specifically looking for industry partners to address unmet needs in neurodegenerative disease areas.

Portfolio highlights

• 400F — 400F develops services to solve problems related to people's lives and assets. It was founded in 2017 and is headquartered in Tokyo.
• Issin — Issin manufactures bath mats that can measure weight and automatically record daily weight changes on your smartphone.
• KAERU — KAERU offers financial and payment services to make shopping more convenient.

Portfolio highlights

• Fools — Fools is a footwear manufacturing company.
• EF Polymer — EF Polymer Private Limited providing 100% Organic and fully Biodegradable Super Absorbent Polymer cum Fertilizer to reduce Water and Fertilizer requirement for your plant. Let's grow organically.
• ACCEL Stars — ACCEL Stars is a fitness and wellness firm that offers sleep diagnosis and examinations like sleep health, hygiene and medical devices.