Top 50 Health Care Startup Investors in Japan (June 2026)

Portfolio highlights

• Diggle — DIGGLE is a service that provides fundamental management accounting management on the cloud called fraud management. It is possible to reduce the mistakes and man-hours of the fraud management task and easily carry out the fraud management task even if it is not an expert in finance or accounting.DIGGLE covers budget creation work and budgetrecord comparison work, especially in the foreman management work. In the budget creation work, the KPI and the budget are automatically created by inputting the target numerical value to the preset parameters utilizing the budget generator function, while the forecast contrasting work is made up of the financial information, non-financial information It is easy to calculate by simply entering the numerical value, and it is possible to carry out calculation of the forecast contrast.
• Fermelanta — Fermelanta produces rare plant-based ingredients through microbial fermentation. It engineers a cell to build a biosynthetic pathway of target molecules with gene transfer and disruption.
• Japan Culture and Technology — Japan Culture and Technology assists artists and craftspeople in expanding their activities by providing IT support.

Portfolio highlights

• Letara — Letara operates a space technology platform with the intention to serve a logistics network covering the solar system. The company produces hybrid propulsion engines for small spacecraft, promoting groundbreaking advances in space propulsion with high thrust, safe, and inexpensive propulsion system technology.
• Pragtech — Pragtech develops and operates parking lot service software that helps to eliminate payment congestion and reduce operating costs.
• Metro Weather — Metroweather is a venture from Kyoto University that develops a high-performance Doppler lidar that measures the direction and speed of wind several tens of kilometers away from minute movements of fine particles in the atmosphere. We aim to contribute to the safety of the sky by completing a three-dimensional wind map, which has never beenrealized,based on years of research at the Kyoto University Research Institute for Sustainable Areas.

Portfolio highlights

• MOVeLOT — MOVeLOT is an AI company that provides skeletal platform and robot planning, development, and production services.
• Chaintope — Chaintope is specializes in blockchain technology with a focus for FinTech and non-FinTech sectors.
• xCARE — xCARE specializes in the development and commercialization phases of the pharmaceutical and medical device industries.

Portfolio highlights

• CastBio — Castbio specializes in antibody-drug conjugate-based drug discovery research and development. Along with medications, it also creates research reagents, medical equipment, in vitro diagnostic items, and offers drug discovery consulting.
• Illumi Medical — Illumi Medical is a manufacturing company that produces medical equipment and devices for the healthcare sector.
• Reborna Biosciences — Reborna Biosciences provides research and development in the field of genetic diseases. The company develops therapeutic options for area of unmet medical needs in genetic rare disease. The company's technology enables low-molecular compounds to target ribonucleic acid. The company provides new disease-modifying drugs for patients sufferingfrom rare genetic diseases including spinal muscular atrophy.

Portfolio highlights

• Global Vascular —
• Sonire Therapeutics — Sonire Therapeutics provides High-Intensity Focused Ultrasound treatment for cancer.
• Neusignal Therapeutics — Neusignal Therapeutics is a medical company that develops therapeutic medicines for dementia and psychiatric illnesses.

Portfolio highlights

• Menou — MENOU specializes in AI technology and sensing technology. It features a graphical image identification modeler software.
• Castee — Castee provides social collaboration services and also helps with a tool for job requests and overseas projects for creators.
• 3S — 3S is a SaaS developer platform that provides and operates 24-hour home nursing care services through technology.

Portfolio highlights

• Gecipe — Gecipe is a video service for e-sports players.
• Issues — Issues provides development and management of web service issues that solve the problems.
• SecureNavi — SecureNavi offers automation tools for the information security management system. It reduces conventional analogue operations using excel and word. For inquiries, telephone numbers and physical addresses are available on their website.

Portfolio highlights

• Logiless — Logiless is a cloud type all-in-one software dedicated to net shop. Since both orders and stocks can be managed together in a logical manner, efficiency of operations can be realized at low cost.
• LUC — LUC is a provider of the AI ​​x experience analysis platform "TERUS," .
• Turing — Turing develops and manufactures fully autonomous vehicles.

Portfolio highlights

• ImmunoScape — ImmuniScape discovers and develops novel TCR-based therapeutics against solid tumors
• Metcela — Cells hold endless possibilities. Through science, we will unlock these potentials and harness them to improve the lives of patients worldwide.
• Startbahn — Startbahn develops Startrail, a sustainable and scalable blockchain infrastructure that assures the reliability, authenticity, and traceability of artworks.

Portfolio highlights

• QunaSys — Quantum physics is a relatively new field built since the beginning of the 20th century, but we have used MRI (nuclear magnetic resonance equipment) and lasers used for close examinations in hospitals, and semiconductors mounted on computers. Supports the technology that supports the daily life of people.QunaSys was established to bring out thequantum physics that has been active behind the scenes to the front stage, and to make use of quantum properties to realize technologies that could not be achieved with existing technologies.
• Luxna Biotech — Luxana Biotech is established to contribute to medical treatment for suffering patients, .
• Celaid Therapeutics — Celaid Therapeutics specializes in manufacturing and sales of regenerative medicine products utilizing human hematopoietic stem cells.

Portfolio highlights

• ElleThermo — elleThermo aims to implement Semiconductor-Sensitised Thermal Cells (STCs), an energy conversion technology that can generate electricity from unused waste heat above room temperature.
• Aeterlink — Aeterlink is a wireless device maker and developer. They applied their technology to fields such as FA, robots, smart houses, and medicine and developed practical level technologies such as elemental technology that can wirelessly supply power.
• Metagen Therapeutics — Metagen Therapeutics is a Drug discovery and medical business company which utilizes microbiome science.

Portfolio highlights

• Plott — Plott producing youtube animation platform under Vision “Become a Content holder from YouTube”. In August 2019, the company name was changed from Fabo to Plott. Plott, the new company name, is derived from the plot that you make before writing novels, etc., and the idea that “I want to make content all the time” is put in the company name.
• Sharing Energy — Sharing Energy is providing energy supply and energy management services.
• The Chain Museum — The Chain Museum creates a platform for connecting individuals .

Portfolio highlights

• Ashirase — Ashirase is a developer of a walking navigation system for the visually challenged. The company assists visually impaired people in walking independently. This also allows the user to have more attention to spare for audible warnings in their environment. It includes voice input and guidance via a smartphone app. A vibration interface is attachedto their shoes.
• Ken Robotec — Ken Robotec is a construction company that provides labor-saving solutions.
• MaterialGate — MaterialGate focuses on single-molecule dielectrics, developing technologies for devices with better electronic characteristics.

Portfolio highlights

• Linqmed — Linqmed is a pharmaceutical company that specializes in the research and development of radiopharmaceuticals for cancer treatment.
• Simple Form — Simple Form provides real-time information on all domestic corporations necessary for financial institutions. We will accelerate the time-consuming and labor-intensive research work of corporations and take on the role of new financial underpinnings.
• Japan Culture and Technology — Japan Culture and Technology assists artists and craftspeople in expanding their activities by providing IT support.

Portfolio highlights

• Yadokari — Yadokari provides various types of Construction & Real Estate related other services.
• FullDepth — FullDepth is a drone development company.
• Peco Free — Peco Free is a school meal pre-order service that is selected using a smartphone.

Portfolio highlights

• Josan-shes — Josan shes is web start up that offers nursing service to women and babies.
• ACCEL Stars — ACCEL Stars is a fitness and wellness firm that offers sleep diagnosis and examinations like sleep health, hygiene and medical devices.
• Cellid — Cellid developing the waveguide-architecture display module for AR glasses and high-performance spatial recognition software.

Portfolio highlights

• LQUOM — QWAVE offers cryptography communication technology.
• Captain Fresh — Captain Fresh is a freshwater fish and seafood supply chain platform. Captain Fresh is a B2B marketplace leveraging technology to deliver the fastest harvest-to-retail in the industry. The company focuses on aggregating the fragmented retail demand across the country and linking them to the small fishermen and farmers throughout the Indian coast.The company was founded in 2019 and is based in Bengaluru, India.
• Sonire Therapeutics — Sonire Therapeutics provides High-Intensity Focused Ultrasound treatment for cancer.

Portfolio highlights

• Mokable — MOKABLE is a startup introducing a new concept called "eating coffee," aiming to let consumers fully enjoy the flavor of carefully grown coffee beans. Their product uses finely ground whole coffee beans to enhance and maximize the rich aroma and taste of the coffee.
• Syukatsu Labo — Syukatsu Labo is a leading company that solves various problems in an aging society.
• Tensor Energy — Creating the operating system of our zero-carbon, distributed energy future

Portfolio highlights

• OptQC — OptQC commercializes cutting-edge optical quantum computing technologies developed by the Furusawa-Endo Laboratory. Because optical quantum computers are more scalable than superconducting and other quantum computing implementations, OptQC's optical quantum computers should reach this scale. They also have benefits like faster processing andreduced power consumption, which makes optical quantum computers a possible long-term pinnacle of quantum technology.
• Triorb — Triorb is a technology company that specializes in robot mobility development with the help of software and hardware solutions.
• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.

Portfolio highlights

• Chefaa — Chefaa is a GPS-enabled pharmacy benefits platform connecting patients & pharmacies nation-wide to help patients manage all their pharmacy needs. Chefaa uses big data, data ming & machine learning
• Rest Less — Rest Less is the UK's fastest growing digital community for the over 50s. Join for free. Restless offers content, guidance and resources on a range of topics spanning Work and Careers, Volunteering, Learning, Money, Health, Lifestyle and Relationships.
• ChromaCode — ChromaCode is a molecular diagnostics company focusing on bioinformatics. It leverages patented mathematical methods and algorithmic enhancements to enrich signal processing from life science instrumentation. The company uses this to extract new information on biochemistry reactions and substantially increase the performance capabilities of today’sgold-standard biochemical assays at a very low cost.ChromaCode was founded in 2012, ChromaCode is headquartered in Carlsbad, California.

Portfolio highlights

• FR8Labs — FR8Labs offers a practical freight forwarder solution that includes all of the modules required, without the extraneous trappings of overly sophisticated features that may not use but wind up paying for.
• Runchise — Runchise is an integrated restaurant and franchise management system to increase operational efficiency and profit.
• Fresh Factory — Fresh Factory runs a web of hyperlocal cold-chain fulfilment centers in Indonesia.

Portfolio highlights

• Paytner — yup is providing services to support freelance people's funding.The freelance population in Japan has been shown to continue to increase in many Chosa. While working styles are diversified, they are not able to respond to the development of the working environment, and they will develop their business to change the situation where problemssuch as funding, credit, sexual harassment, and power harassment are accumulated.
• Akari Hosho — Akari Hosho provides a group of trusted professionals, including lawyers and judicial scriveners. Akari Hosho provides a guarantee service.
• Black Cat Carnival — Black Cat Carnival Inc. is a communication service development company.

Portfolio highlights

• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.
• VLP Therapeutics — VLP Therapeutics, LLC (VLP) was established in 2012 by seasoned biopharmaceutical veterans with mission to develop innovative medical treatment which transforms traditional vaccine and targeted antibody therapies to address global unmet medical needs. Its vision is to combat the 21st century global public health problems through revolutionary nextgeneration i-αVLP (inserted alpha VLP) Technology. The company is headquartered in Gaithersburg, Maryland
• XFOREST Therapeutics — xFOREST Therapeutics develops a drug discovery platform that targets RNA structures.

Portfolio highlights

• 3DC — 3DC develops and manufactures a new carbon material, graphene meso sponge (GMS), for electrodes in next-generation batteries, capacitors, fuel cells and other energy storage and generation devices.
• THE PHAGE — The phage is a medical device company that focuses on developing AI technology to predict postprandial blood glucose levels.
• Mira Robotics — Mira Robotics is a software based company provide services that can robots in various fields.

Portfolio highlights

• Godot — Godot's mission is to “inspire personal and societal growth through human augmentation”. As part of this mission, we are developing a Behavior Intelligence Platform (BIP) that helps enterprises improve UX, CX, and EX by visualizing human behavior principles and making it easy for anyone to implement insights from behavioral science. Thisplatform leverages evidence from behavioral sciences and advanced AI technologies. Our technology has already proven successful in health insurance industries, resulting in significant improvements in customer retention and satisfaction. Our team comprises experts in AI, behavioral science, and industry-specific applications, bringing a wealth of experience and knowledge to our solutions. Together, we are committed to creating a society where everyone can enjoy a healthy and fulfilling life, true to themselves, with the support of Godot's innovative technologies.
• SecureNavi — SecureNavi offers automation tools for the information security management system. It reduces conventional analogue operations using excel and word. For inquiries, telephone numbers and physical addresses are available on their website.
• Mirai no Genba — Mirai no Genba is an IT company that offers AI form creation, input assist, data analytics,and visualization services.

Portfolio highlights

• Banzai — Leverage Banzai's event solutions to transform your bored registrants into paying customers. Learn more about Reach and Demio today.
• Siftery — Siftery is a database of sorts where companies list their software stacks. Siftery compares companies with similar stacks and looks for differences to make some recommendations.
• Zehitomo — Zehitomo is an Japanese online platform that enables user to hire local service professionals, from photographers to personal trainers.

Portfolio highlights

• Kinish — Kinish is a company leading a revolution in dairy products. To achieve environmentally friendly and delicious dairy products, we are developing a special rice variety that produces milk proteins.
• Kwahuu Ocean — Kwahuu Ocean develops sustainable squid farming systems.
• Spine Chronicle — Spine chronicle is a medical device manufacturing firm that specializes in developing orthopedic medical equipment.

Portfolio highlights

• Nexta — Nexta manufactures site, issues such as analog management, personalization of operations & labor shortages are becoming more serious.
• Logo Labo — Logo Labo provides branding and marketing services, including brand development, formulation, IT-based branding and marketing support.
• MUSE — MUSE is a robotics company that provides robotic solutions for retail stores to support in-store operations.

Portfolio highlights

• Sapyen — We take the fear out of infertility for men. Test for it at home, without stepping out to the hospital and get personalised health recommendations to improve sperm health and increase your chances of conceiving.
• Superflex — Elevate your workflow with Superflex, the ultimate Figma-to-code solution. Our AI instantly converts Figma and Image designs into pixel-perfect, production-ready code that meets your standards and boosts team efficiency.
• One Key Access — One Key Access is an interface to the world of couriers to enable 24/7 frictionless deliveries.

Portfolio highlights

• A-SEEDS — A-SEEDS, an innovative biotech company sprouted from Shinshu University, is dedicated to pioneering advanced treatments for life-threatening cancers. Harnessing the potential of non-viral genetic engineering, our cutting-edge immune cell therapy opens up new horizons of hope for patients seeking effective and transformative solutions.
• AMI — AMI Corp is engaged in medical consulting, medical device development and writing.
• Do. Sukasu — Do. Sukasu is a software company that specializes in the development of visual space perception ability for brain science approaches.

Portfolio highlights

• Z-Works — "Z-Works Life Engine" is a cloud-type IoT platform. Collect and analyze the data of the terminal equipped with Z-Wave on the cloud, you can browse various data with the smartphone and remotely control the terminal equipped with Z-Wave.
• NovAccel — NovAccel operates as a deep tech company, ensure a stable supply of medical radioisotopes.
• Sonire Therapeutics — Sonire Therapeutics provides High-Intensity Focused Ultrasound treatment for cancer.

Portfolio highlights

• Autify — AI software testing company aimed at solving the challenges associated with automation testing. We are passionate about making software testing faster and easier, empowering companies to release faster and keep their applications stable.
• Nekonome — Nekonome creates a game platform with global character designs, in-game updates, and regular events, providing a personalized gaming experience based on data.
• AVA Intelligence — AVA Intelligence is a Internet service development company.

Portfolio highlights

• Fivot — Fivot is a financial company that provides venture capital, financing, credit, money lending, and prepaid payment services.
• Plainer — Plainer is an IT company that provides software development, data management, and SaaS solutions.
• CraftBank — CraftBank, Inc. is the start-up that operates online matching platform between constructors with having relations with 22k specialty constructors (10% coverage in the market). The company was succeeded in Management BuyOut in April 2021.

Portfolio highlights

• Piazza — PIAZZA deploy the regional platform PIAZZA.
• FullDepth — FullDepth is a drone development company.
• Gaudi Clinical — Gaudi Clinical is a health care firm that engages in regenerative medicine outsourcing and cell processing contract establishments.

Portfolio highlights

• Issin — Issin manufactures bath mats that can measure weight and automatically record daily weight changes on your smartphone.
• RoboTruck — RoboTruck develops autonomous driving technologies for huge trucks, as well as practical applications.
• Leading Mark — Leading Mark, a rising human resources startup in Japan. Leading Mark is branching out into mid-career and international hiring. It currently has a one-man team in China working to bring the top Japanese-speaking Chinese students to domestic companies. He also touts his startup’s focus on the average job seeker. “We want to make sure that the usersget the info that he or she needs the most,” he says. Large scale, legacy players can sometimes prioritize the needs of the hiring company, and their commission, over the needs of applicants themselves. This leads to frustration and short-circuited careers.

Portfolio highlights

• Airato — Airato specializes in the development of radiation therapy using artificial intelligence technology.
• CELLORB — CELLORB provides player management, sports event planning, and event management services.
• Illumi Medical — Illumi Medical is a manufacturing company that produces medical equipment and devices for the healthcare sector.

Portfolio highlights

• Logomix — Logomix Inc is a mammalian cellular genome architect startup. Logomix proprietary platform, Geno-Writing™, technology integrates large-scale (Mb) human genome-writing technologies and providing genetically architected versatile human cells and/or downsized cells and microbes for drug development and cell & gene therapy area.Majority ofthe cell engineering companies are currently focused on optimization of gene clusters by automatic high throughput system however, Logomix’s Geno-Writing™ provides the required tools for dealing with mammalian or complex genomes. Logomix works with partners by providing new biology-based solutions to co-create business and social values on Geno-Writing™ platform Current Focus Area includes: 1. Human Health & Therapeutics 2. Biomaterials & Chemicals 3. Agriculture & EnvironmentLogomix has 11 ongoing collaborative research partnerships. Currently Logomix is specifically looking for industry partners to address unmet needs in neurodegenerative disease areas.
• CMerTV — CMer TV is a platform that connects advertisers with newspapers, magazines, and specialized media by video
• Link Therapeutics — Link Therapeutics specializes in developing therapeutic methods for targeting autoantibodies and identifying pathogenic autoantibodies.

Portfolio highlights

• MOVeLOT — MOVeLOT is an AI company that provides skeletal platform and robot planning, development, and production services.
• Kisui Tech — Kisui Tech is an agricultural AI robotics company that help farmers for farming.
• LYMPHOGENiX — LYMPHOGENiX is the pioneer company for lymphatic vessels regeneration. Our proprietary technology revitalizes the function of lymphatic vessels, making us experts in treating various health conditions. Our treatment is also great for skin-aging, obesity, Alzheimer's diseases and infertility. We believe in helping our clients improve their vitality and energy, one treatment at a time.

Portfolio highlights

• LIFESCAPES — LIFESCAPES is a research and manufacturer of brain-computer interface equipment.
• Metcela — Cells hold endless possibilities. Through science, we will unlock these potentials and harness them to improve the lives of patients worldwide.
• Hirosaki Lifescience Innovation — Hirosaki Lifescience Innovation is engaged in the development, manufacture, and sale of regenerative medicine products.

Portfolio highlights

• LEP —
• SecureNavi — SecureNavi offers automation tools for the information security management system. It reduces conventional analogue operations using excel and word. For inquiries, telephone numbers and physical addresses are available on their website.
• Akari Hosho — Akari Hosho provides a group of trusted professionals, including lawyers and judicial scriveners. Akari Hosho provides a guarantee service.

Portfolio highlights

• Nstock — Nstock is specialized in developing SAAS based applications for ecosystem.
• STRACT — STRACT is a web platform that provides online platform, dating app, knowledge sharing cloud platform, and casual entertainment services.
• PartnerSuccess — PartnerSuccess develops and provides SaaS tools that automate the collaboration between manufacturers and distributors.

Portfolio highlights

• RebuilderAI — A new way to bring imagination into the real world
• Pickleball One — Pickleball one is to become an enabler of the pickleball industry , spreading the joy of "Fun as one" to the world.
• Digital Entertainment Asset — DEA is an Entertainment Solution Company that continues to propose next-generation solutions to challenges through Web3, gaming mechanisms, and the utilization of DePIN.

Portfolio highlights

• Bloomo Securities — Bloomo Investment is a software company that specializes in the development of smart and fun investment apps.
• Spiral.AI — Spiral.AI offers services for large language models, AI language model platform, and customization features for ChatGPT for businesses.
• OWNY — Manage capital, investors and treasury

Portfolio highlights

• Pictoria — Pictoria produce total events for entertainment.They handle a wide range of events, from talk events to events using advanced technologies such as 3D motion capture.
• Forward — Forward is a SaaS-based startup that offers recruitment agency services.
• Illumi Medical — Illumi Medical is a manufacturing company that produces medical equipment and devices for the healthcare sector.

Portfolio highlights

• Sazo — Sazo specializes in constructing a global e-commerce and logistics network with AI.
• Pragtech — Pragtech develops and operates parking lot service software that helps to eliminate payment congestion and reduce operating costs.
• Shinsekai Technologies — SHINSEKAI Technologies focuses on supporting companies, enabling them to advance their services to Web3 and NFT technologies.

Portfolio highlights

• SOUNDRAW — Your personal AI music generator.
• Inter Holding — Inter delivers solutions for global difficulties using vacuum technology, which uses a particular check valve to maintain a 99.5% vacuum rate.
• Better Place — Better place vision is to create a world in which kind people can continue to be kind, as well as a society in which people can work in their own way without worrying about money.

Portfolio highlights

• Hacobu — Hacobu offers an integrated solution "MOVO (MOVO)" centering on the operation management system utilizing in-vehicle terminals. Connect with carriers and shipping companies sending luggage using an easy-to-use online mechanism. To provide tools to support the management of the shipping company. Through these, it becomes a platform toaccumulate distribution data of various companies, aiming at overall optimization of physical distribution system. That is, "to optimize carrying". That is Hacobu 's mission.
• TeraWatt Technology — Electrifying all for the sustainable future
• Metagen Therapeutics — Metagen Therapeutics is a Drug discovery and medical business company which utilizes microbiome science.

Portfolio highlights

• Airato — Airato specializes in the development of radiation therapy using artificial intelligence technology.
• Robofull — Robofull is a manufacturing firm that specializes in the design and sale of automation equipment for factories to solve the labor shortage.
• Illumi Medical — Illumi Medical is a manufacturing company that produces medical equipment and devices for the healthcare sector.

Portfolio highlights

• Sagri — Sagri is developing agriculture software for experienced farmers.
• Good News — Good News is a staffing agency that provides recruitment, public relations, and human resource management services.
• Rehabilitation 3.0 — Rehabilitation 3.0 focuses on a preventive medical system that provides AI assessment and tracking on health, exercise, mood, and wellness.

Portfolio highlights

• Molmir — Molmir is a biotech company that conducts research and develops treatments for intractable diseases based on sensing technology.
• Photo Electron Soul — Photo electron Soul mission is to innovate the world of "seeing (fine observation)" and "creating (fine processing)" through the development of photocathode electron beam technology.　The photocathode electron beam technology developed by our company will produce next generation electron beams with high performance andversatility (pulse structure, low dispersion, large current). By renewing the electron beam, which is a key device for industrial equipment such as electron microscopes, semiconductor device manufacturing / inspection equipment, and metal 3D printers, it is possible to realize fine observation, fine processing, high throughput, etc. Breakthroughs in a wide range of fields such as science, materials, and electronics.
• Restore Vision — Restore Vision is a startup based in Japan aiming to develop a visual restoration gene therapy.