Top 50 Health Care Startup Investors in Japan (July 2026)

Portfolio highlights

• Tacoms — CAMEL is a service that allows you to easily manage orders from multiple food delivery / takeout services on a single tablet.
• Any Style —
• Smile Robotics — Smile Robotics provides Service Robots in Japan.

Portfolio highlights

• Fermelanta — Fermelanta produces rare plant-based ingredients through microbial fermentation. It engineers a cell to build a biosynthetic pathway of target molecules with gene transfer and disruption.
• Atom — Atom is a humanoid robot built platform. Its bipedal, dual-armed robots are designed not just as industrial tools but as collaborators that expand human capability. By combining advanced Physical AI—environmental perception, judgment, and action planning—with robust robotic hardware, Atom is creating adaptive agents capable of working acrossdiverse settings to augment or, where appropriate, replace human labor. The company positions these robots as a next step in societal evolution: a new class of machines that learn and behave in human-like ways to advance productivity, safety, and quality of life.
• Link Therapeutics — Link Therapeutics specializes in developing therapeutic methods for targeting autoantibodies and identifying pathogenic autoantibodies.

Portfolio highlights

• Diggle — DIGGLE is a service that provides fundamental management accounting management on the cloud called fraud management. It is possible to reduce the mistakes and man-hours of the fraud management task and easily carry out the fraud management task even if it is not an expert in finance or accounting.DIGGLE covers budget creation work and budgetrecord comparison work, especially in the foreman management work. In the budget creation work, the KPI and the budget are automatically created by inputting the target numerical value to the preset parameters utilizing the budget generator function, while the forecast contrasting work is made up of the financial information, non-financial information It is easy to calculate by simply entering the numerical value, and it is possible to carry out calculation of the forecast contrast.
• Luxna Biotech — Luxana Biotech is established to contribute to medical treatment for suffering patients, .
• Link Therapeutics — Link Therapeutics specializes in developing therapeutic methods for targeting autoantibodies and identifying pathogenic autoantibodies.

Portfolio highlights

• CastBio — Castbio specializes in antibody-drug conjugate-based drug discovery research and development. Along with medications, it also creates research reagents, medical equipment, in vitro diagnostic items, and offers drug discovery consulting.
• 3DC — 3DC develops and manufactures a new carbon material, graphene meso sponge (GMS), for electrodes in next-generation batteries, capacitors, fuel cells and other energy storage and generation devices.
• Formas.AI — Formas.AI is a multi-modal, AI-powered design platform specifically built for architects, designers, and educators to generate and visualize creative architectural concepts.

Portfolio highlights

• NovAccel — NovAccel operates as a deep tech company, ensure a stable supply of medical radioisotopes.
• Sonire Therapeutics — SONIRE Therapeutics Inc. (SONIRE) is working on a next-generation high-intensity focused ultrasound (HIFU) therapy system that will employ acoustic engineering (ultrasound) technologies developed through cutting-edge academic research. SONIRE has been working on a next-generation high-intensity focused ultrasound (HIFU) treatment system as a noveltherapeutic modality with the goal of giving cancer patients and their families a new future.
• Neusignal Therapeutics — Neusignal Therapeutics is a medical company that develops therapeutic medicines for dementia and psychiatric illnesses.

Portfolio highlights

• Cake.jp — Cake.jp operates "Cake.jp", a comprehensive cake delivery site.
• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.
• Fabric Tokyo — FABRIC TOKYO is a Japanese startup provides a direct-to-consumer custom-made apparel brand. (former-company name Lifestyle Design Co., Ltd.). It enables customers to save their sizes, idea fabrics, and favorite designs, allowing them to make their original clothing later.FABRIC TOKYO was founded in 2012 by Yuichiro Mori and is based in Tokyo,Japan.

Portfolio highlights

• CaTe —
• EISHIN — EISHIN is a technology company that specializes in pet tech business, recruitment consulting, website creation, and development services.
• Yokohama Vanilla — Yokohama Vanilla is a Company which operates Yokohama-based gift sweets brand.

Portfolio highlights

• CaTe —
• FunPep — FunPep is an Industry-university collaboration bioventure company.
• NEXT NEW WORLD — NEXT NEW WORLD develops and manufactures natural products with low impact on the environment. It uses sustainable Japanese silk to manufacture apparel and cosmetic products.

Portfolio highlights

• Menou — MENOU specializes in AI technology and sensing technology. It features a graphical image identification modeler software.
• Space BD — Space BD aims to become a one-stop shop to respond to all issues related to industrialization of space, and alleviate the work of businesses that are developing new technologies.
• Neusignal Therapeutics — Neusignal Therapeutics is a medical company that develops therapeutic medicines for dementia and psychiatric illnesses.

Portfolio highlights

• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.
• TXP Medical — TXP Medical build a next-generation medical system through acute care.
• Startbahn — Startbahn develops Startrail, a sustainable and scalable blockchain infrastructure that assures the reliability, authenticity, and traceability of artworks.

Portfolio highlights

• JiMED — JiMED designs & develops AI based brain-computer interface for implant in ALS patients to improve communication.
• Grafenary — Graphenary creates unique graphene optical devices using graphene materials with a variety of remarkable features.
• Neusignal Therapeutics — Neusignal Therapeutics is a medical company that develops therapeutic medicines for dementia and psychiatric illnesses.

Portfolio highlights

• JiMED — JiMED designs & develops AI based brain-computer interface for implant in ALS patients to improve communication.
• LQUOM — QWAVE offers cryptography communication technology.
• Toregem BioPharma — Toregem BioPharma is a startup from Kyoto University that develops a treatment for congenital adentia. Toregem BioPharma is headquartered in Kyoto, Japan.

Portfolio highlights

• Ginco — Ginco's goal is to Change the relationship between individuals and assets by making full use of block chain technology. The primary focus of Ginco, its cryptocurrency wallet app, is centered around dApp and the On-Chain function, and the company plans to expand its business in a multifaceted manner while watching trends in the ecosystemdevelopment. In the future, they were told that they have the possibility of developing with DEXs (decentralized exchanges).
• Scohia Pharma — Scohia Pharma is a biotech venture that will have both substantial research and development resources and be nimble enough to make decisions quickly, will strive to improve patient quality of life by providing patients and healthcare professionals with new therapeutic medications for renal, metabolic.
• Arrowsmith — Arrowsmith is committed to unlocking the full potential of bacteriophages to revolutionize the treatment of bacterial infectious diseases. Through transformative science, Arrowsmith strive to create a world free from the pain and fear caused by antimicrobial resistance.

Portfolio highlights

• Ashirase — Ashirase is a developer of a walking navigation system for the visually challenged. The company assists visually impaired people in walking independently. This also allows the user to have more attention to spare for audible warnings in their environment. It includes voice input and guidance via a smartphone app. A vibration interface is attachedto their shoes.
• Ken Robotec — Ken Robotec is a construction company that provides labor-saving solutions.
• MaterialGate — MaterialGate focuses on single-molecule dielectrics, developing technologies for devices with better electronic characteristics.

Portfolio highlights

• AI Mage —
• Umami United — Umami United is a plant-based food brand with unique focus on Japanese food technologies and traditional ingredients to make delicious and healthy food to unite people at one table. The wide lineups are designed to be vegan-friendly, buddhist friendly, and halal friendly for all.
• Albatross Technology — Albatross Technology is a technology company that develops offshore renewable energy devices and floating offshore wind turbines.

Portfolio highlights

• Moi — Moi Corporation was founded to deliver on the promise of the Twitcasting social live streaming platform. We developed Twitcasting to enable people to stream and share live video anytime, anywhere - connecting the world in real-time. TwitCasting provides a live streaming social platform that enables real-time chat between broacasters andviewers, through apps or desktop. Users can follow their favorite broadcasters and receive notifications when new a new live stream is about to start. Broadcasters can save and publish their live streams for later viewing.In early 2014 we added "Collabo" to Twitcasting, enabling as many as 6 users to broadcast together, in a single display. Viewers can join a broadcast that is already streaming live and broadcast together. It is the first app to support multi-device broadcasting in a single stream on mobile and PC. Our user base has doubled every year, and hit 7.5 million in September, 2014. While the largest part of our base is in Asia, users in US, Brazil, Mexico and other Latin American countries are now growing rapidly. About 70% of our users are under 25 years old, & approximately 95% of broadcasters shoot on mobile. 
• Wonderplanet — Wonderplanet designs and develops native language applications and games for smart phones and tablets. The company was founded in 2012 and is based in Nagoya, Japan.
• EneCoat Technologies — EneCoat Technologies is working on materials development for perovskite solar cells and the commercialization of modules.EneCoat Technologies will create the future of energy through thin-film solar cells with the aims of protecting the environment and effectively utilizing natural energy sources.

Portfolio highlights

• Naorai — Naorai is a food and beverage firm that manufactures wine, beer, spirits, and non-alcoholic beverages.
• Dioseve — Dioseve is providing novel possibilities for all life.
• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.

Portfolio highlights

• LQUOM — QWAVE offers cryptography communication technology.
• Direava — Direava is a medical device company that manufactures, sells, leases, and maintains medical equipments along with consulting services.
• Zerodoor HD — Zerodoor HD specializes in digital transformation in constructing industry.

Portfolio highlights

• MW — MW is a smart home solution company that develops smart residential physical AI, robotics, and home design services.
• InsightX — InsightX is a technology platform focused on empowering businesses by simplifying complex processes and enabling smarter, more personalized user experiences.
• Neusignal Therapeutics — Neusignal Therapeutics is a medical company that develops therapeutic medicines for dementia and psychiatric illnesses.

Portfolio highlights

• Eko — Turning workplaces into places where all employees can thrive.
• FitHappy — FitHappy is a behavioral & medical-based wellness app to solve diet problems for good.
• Bioma — Media Desa Terkini

Portfolio highlights

• Triorb — Triorb is a technology company that specializes in robot mobility development with the help of software and hardware solutions.
• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.
• Solaris — Solaris commercializes, manufactures, and sells soft robotics using pneumatic artificial muscles. Solaris was founded in 2017 and was headquartered in Tokyo, Japan.

Portfolio highlights

• Yondemy — Yondemy is an online platform for children reading books.
• Yokohama Vanilla — Yokohama Vanilla is a Company which operates Yokohama-based gift sweets brand.
• Zeal Boxing Fitness — Zeal Boxing Fitness combines power of sports with the power of technology to provide a service that allows to enjoy fitness.

Portfolio highlights

• PayJoy — Looking for a phone or a cash loan? PayJoy gives you credit with few requirements and in minutes. No late fees charged.
• Airhouse — Airhouse is the first all-in-one logistics platform for modern direct-to-consumer ecommerce companies. Launch a complex fulfillment operation in seconds.
• Diligent Robotics — We build robots like Moxi that assist hospital staff with routine activities so they can focus on caring for patients.

Portfolio highlights

• Akari Hosho — Akari Hosho provides a group of trusted professionals, including lawyers and judicial scriveners. Akari Hosho provides a guarantee service.
• Black Cat Carnival — Black Cat Carnival Inc. is a communication service development company.
• Pixie Dust Technologies — Pixie Dust Technologies is a developer of computational technologies, including its ultrasonic phased array system with which one can generate force in mid-air; transport things in mid-air without touching anything; target and deliver different sounds from person to person in a crowd; direct guide-dogs; and even apply this in agricultural farming.

Portfolio highlights

• Agentio — Agentio's patent-pending ad platform empowers marketers to finally unlock scalable, creator-led advertising. Programmatically buy the highest quality creator and influencer ad reads to deliver unprecedented efficiency and performance.
• Codis.io — COD LEGAL BLOG CONTACT US Areas We Serve California Florida TEXAS Ohio Trusted Insights on Birth Injury and Medical Negligence Law COD LEGAL BLOG is a dedicated legal information platform created to help readers understand complex legal matters in a clear and structured way. Click here to learn more. The legal system can often feel
• Quantflo — Options market intelligence and structured trade planning for Indian markets.

Portfolio highlights

• Mui Lab — Mui is an aesthetically-pleasing wooden IoT device connected to a cloud service. By accessing information through natural wood, we can rethink a new type of lifestyle.
• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.
• Fermelanta — Fermelanta produces rare plant-based ingredients through microbial fermentation. It engineers a cell to build a biosynthetic pathway of target molecules with gene transfer and disruption.

Portfolio highlights

• Grafenary — Graphenary creates unique graphene optical devices using graphene materials with a variety of remarkable features.
• SecureNavi — SecureNavi offers automation tools for the information security management system. It reduces conventional analogue operations using excel and word. For inquiries, telephone numbers and physical addresses are available on their website.
• NanoFrontier — NanoFrontier continues to market technologies that are widely available and incredibly inexpensive.

Portfolio highlights

• Kinish — Kinish is a company leading a revolution in dairy products. To achieve environmentally friendly and delicious dairy products, we are developing a special rice variety that produces milk proteins.
• Kwahuu Ocean — Kwahuu Ocean develops sustainable squid farming systems.
• Spine Chronicle — Spine chronicle is a medical device manufacturing firm that specializes in developing orthopedic medical equipment.

Portfolio highlights

• AMI — AMI Corp is engaged in medical consulting, medical device development and writing.
• Do. Sukasu — Do. Sukasu is a software company that specializes in the development of visual space perception ability for brain science approaches.
• HEAL-lll — HEAL-lll is a multifaceted firm that merges healthcare, technology, and gamification to promote individual and organizational well-being.

Portfolio highlights

• 3DC — 3DC develops and manufactures a new carbon material, graphene meso sponge (GMS), for electrodes in next-generation batteries, capacitors, fuel cells and other energy storage and generation devices.
• THE PHAGE — The phage is a medical device company that focuses on developing AI technology to predict postprandial blood glucose levels.
• Mira Robotics — Mira Robotics is a software based company provide services that can robots in various fields.

Portfolio highlights

• Kikuvi — Kikuvi develops an AI-driven interview agent that automates question design, execution, and analysis. It eliminates the effort of listening, allowing users to focus their time on decision-making and creativity.
• Mign — Mign offers a generative AI-related SaaS solutions for the construction and real estate fields.
• Innovative Space Carrier — Innovative Space Carrier is a aerospace company that offers space transportation systems, planning, drafting and technology strategies.

Portfolio highlights

• Recerqa — Recerqa is a supply chain management SaaS that utilizes advanced development technology and AI to improve the purchasing, inventory, and sales management experiences.
• Mign — Mign offers a generative AI-related SaaS solutions for the construction and real estate fields.
• Henry — Henry develops and provides a cloud-based electronic medical record and receipt system for small and medium-sized hospitals.

Portfolio highlights

• NovAccel — NovAccel operates as a deep tech company, ensure a stable supply of medical radioisotopes.
• AstroX — AstroX is a private space startup company that develops satellite launch vehicles for space development. It utilizes the rockoon method for developing launch vehicles and small rockets to help clients easily use space.
• Sonire Therapeutics — SONIRE Therapeutics Inc. (SONIRE) is working on a next-generation high-intensity focused ultrasound (HIFU) therapy system that will employ acoustic engineering (ultrasound) technologies developed through cutting-edge academic research. SONIRE has been working on a next-generation high-intensity focused ultrasound (HIFU) treatment system as a noveltherapeutic modality with the goal of giving cancer patients and their families a new future.

Portfolio highlights

• PIMTO — PIMTO Corporation is a technology company that provides digital solutions for location and facility management. Through its PIMT-0 service, it supports airports, stations, commercial facilities, hotels, factories, and public organizations in improving operations, profitability, and customer satisfaction. The company also focuses on addressingsocial challenges such as overtourism, regional revitalization, remote work creation, and improving access to essential services.
• Kakutoku — Nitlon Inc. provides crowdsourcing management services. The company was founded by Seiya Mitsuda on February 02, and is headquartered in Beppu, Japan.
• AlarmBox — AlarmBox develops services that make use of professional knowledge of technology and corporate screening, and changes common sense of risk management of enterprise.

Portfolio highlights

• CELLORB — CELLORB provides player management, sports event planning, and event management services.
• L&F — L&F is a real estate company that develops rental portals and tools for vacant houses, family trusts, and rental property management.
• Illumi Medical — Illumi Medical is a manufacturing company that produces medical equipment and devices for the healthcare sector.

Portfolio highlights

• NodeX — We build open-source embedded software and cloud tools to help developers build secure IoT products, simply. By leveraging decentralized identity and h/w root of trust technology, IoT security platform "UNiD" enables developers to automate device management and easily build secure data pipeline between every devices and the cloud.
• Simplex Quantum — Simplex Quantum conducts research and development of AI-based solutions in the healthcare field and operates the SQ-bar service.It also offers the Shinden-kun, a portable device that can analyze the measured electrocardiographic information with AI and detect heartbeat turbulence.It was established on October 3, 2014 and headquartered inTakanawa, Minato-ku.
• Link Therapeutics — Link Therapeutics specializes in developing therapeutic methods for targeting autoantibodies and identifying pathogenic autoantibodies.

Portfolio highlights

• Issin — Issin manufactures bath mats that can measure weight and automatically record daily weight changes on your smartphone.
• RoboTruck — RoboTruck develops autonomous driving technologies for huge trucks, as well as practical applications.
• Leading Mark — Leading Mark, a rising human resources startup in Japan. Leading Mark is branching out into mid-career and international hiring. It currently has a one-man team in China working to bring the top Japanese-speaking Chinese students to domestic companies. He also touts his startup’s focus on the average job seeker. “We want to make sure that the usersget the info that he or she needs the most,” he says. Large scale, legacy players can sometimes prioritize the needs of the hiring company, and their commission, over the needs of applicants themselves. This leads to frustration and short-circuited careers.

Portfolio highlights

• Dwilar — Dwilar is a proptech company that provides AI-powered leasing solutions tailored for international buyers seeking property. Their platform enables users to design flexible lease agreements with the option to own, allowing for property customization and renovation during the lease period. By avoiding dollar-denominated loans, it minimizes currencyexchange risks and offers a streamlined and personalized path to property acquisition.
• Synflux — Synflux is a fashion lab comprising of fashion designers, software engineers & architects focused on fashion industry.
• EF Polymer — EF Polymer Private Limited providing 100% Organic and fully Biodegradable Super Absorbent Polymer cum Fertilizer to reduce Water and Fertilizer requirement for your plant. Let's grow organically.

Portfolio highlights

• Balus — Balus provides motion capture, Unity systems, and AR live permanent venues.The company provides character content infrastructure using real-time animation, we also support the production of original content. Balus provides the necessary technology for event planning, casting, VR events, recording and creation of production images, real-timemotion capture during live events, real-time transmission, event management, and systems that allow users to participate in the production.
• Pale Blue — Water propulsion systems for sustainable space development
• OPTEMO — OPTEMO develops and supplies sales technology that allows businesses and customers to connect through a website.

Portfolio highlights

• Dioseve — Dioseve is providing novel possibilities for all life.
• Yuimedi — Yuimedi acquires, investigate, analyze medical data and provides accurate solutions.
• Free Standard —

Portfolio highlights

• Koeda — KOEDA is researching and developing medical devices that are safe, painless, and easy to use for acute cholecystitis. KOEDA will transform the management of cholecystitis. So far, endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) has been a notably difficult procedure carried out by skilled doctors at specific advanced centers. Althoughinserting a tube into the gallbladder is less invasive, it is complex, and there may be concerns regarding bile leakage. By combining clinical expertise with precision engineering, KOEDA addresses a clearly defined medical need in a growing global market and is currently moving forward on schedule for regulatory clearance and commercialization.
• Scohia Pharma — Scohia Pharma is a biotech venture that will have both substantial research and development resources and be nimble enough to make decisions quickly, will strive to improve patient quality of life by providing patients and healthcare professionals with new therapeutic medications for renal, metabolic.
• Storyline — Storyline is a company that use technology and design to address social challenges while building a sustainable society.

Portfolio highlights

• Imiron — Imiron the process and tools used for modeling mathematical behavior in order to comprehend its fundamentals.
• Dioseve — Dioseve is providing novel possibilities for all life.
• CULTA —

Portfolio highlights

• F.MED — F.MED is a manufacturing company that designs and develops robotic microsurgical devices for the healthcare industry.
• Varinos — Varinos is a clinical laboratory contract analysis company that is a partner of medical institutions. Varinos provides genomic testing development and contract analysis services using the latest technology, the next-generation sequencer.
• ElevationSpace — ElevationSpace offers high quality & well equipped workspaces giving tenants a nurturing environment .

Portfolio highlights

• LIFESCAPES — LIFESCAPES is a research and manufacturer of brain-computer interface equipment.
• Metcela — Cells hold endless possibilities. Through science, we will unlock these potentials and harness them to improve the lives of patients worldwide.
• Hirosaki Lifescience Innovation — Hirosaki Lifescience Innovation is engaged in the development, manufacture, and sale of regenerative medicine products.

Portfolio highlights

• Henry — Henry develops and provides a cloud-based electronic medical record and receipt system for small and medium-sized hospitals.
• Ruten — Ruten is a brain-machine interface company that specializes in reconstructive treatments for infeasible and ineffective conditions.
• Tokenz — Tokenz is your all-in-one platform for global digital payments, cross-border tax compliance, and seamless payouts.

Portfolio highlights

• RebuilderAI — A new way to bring imagination into the real world
• Pickleball One — Pickleball one is to become an enabler of the pickleball industry , spreading the joy of "Fun as one" to the world.
• Digital Entertainment Asset — DEA is an Entertainment Solution Company that continues to propose next-generation solutions to challenges through Web3, gaming mechanisms, and the utilization of DePIN.

Portfolio highlights

• Eco-Pork — Eco-Pork is a co-creation solution farm that supports farmers' food productivity improvement. It is connecting the pig and technology, pork ( Pork ) new business ecosystems ( Ecosystem By building a), in the pork growing demand around the world, to get the most out of the food supply capacity is finite.
• Equmenopolis — Equmenopolis is an information services company that specializes in conversational AI agent platforms and application developments.
• Surv Biopharma — Surv Biopharma develops a drug discovery platform that facilitates research and development of veterinary drugs and pharmaceutical products.

Portfolio highlights

• DT Axis — DT Axis is a digital health firm that focuses on the research, development, and distribution of medical software, namely in the field of digital therapeutics.
• Linqmed — Linqmed is a pharmaceutical company that specializes in the research and development of radiopharmaceuticals for cancer treatment.
• MabGenesis — MabGenesis is a biopharmaceutical company that provides therapeutic monoclonal antibody drugs in human and animal fields.

Portfolio highlights

• Molmir — Molmir is a biotech company that conducts research and develops treatments for intractable diseases based on sensing technology.
• EUV Photon — EUV Photon is an irradiation services company that conducts processing, evaluation, and measurement of materials for EUV lights.
• Restore Vision — Restore Vision is a startup based in Japan aiming to develop a visual restoration gene therapy.

Portfolio highlights

• MOVeLOT — MOVeLOT is an AI company that provides skeletal platform and robot planning, development, and production services.
• Kisui Tech — Kisui Tech is an agricultural AI robotics company that help farmers for farming.
• LYMPHOGENiX — LYMPHOGENiX is the pioneer company for lymphatic vessels regeneration. Our proprietary technology revitalizes the function of lymphatic vessels, making us experts in treating various health conditions. Our treatment is also great for skin-aging, obesity, Alzheimer's diseases and infertility. We believe in helping our clients improve their vitality and energy, one treatment at a time.