Top 50 Life Science Startup Investors in Japan (June 2026)

Portfolio highlights

• Taian — Taian, which specializes in bridal industry services and software. They also provide ''Concept Marry,'' which allows couples to design invites and seating charts that match their wedding theme, as well as display guest information on Oiwaii.
• Hydro Powtech Japan — Nippon Hydropowtech uses proprietary technology and experience in hydrolysate production to investigate new food applications.
• Mechano Cross — Mechano Cross is a mechanical company that offers mechanochemical organic synthesis technology for solution reactions.

Portfolio highlights

• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.
• VLP Therapeutics — VLP Therapeutics, LLC (VLP) was established in 2012 by seasoned biopharmaceutical veterans with mission to develop innovative medical treatment which transforms traditional vaccine and targeted antibody therapies to address global unmet medical needs. Its vision is to combat the 21st century global public health problems through revolutionary nextgeneration i-αVLP (inserted alpha VLP) Technology. The company is headquartered in Gaithersburg, Maryland
• XFOREST Therapeutics — xFOREST Therapeutics develops a drug discovery platform that targets RNA structures.

Portfolio highlights

• QunaSys — Quantum physics is a relatively new field built since the beginning of the 20th century, but we have used MRI (nuclear magnetic resonance equipment) and lasers used for close examinations in hospitals, and semiconductors mounted on computers. Supports the technology that supports the daily life of people.QunaSys was established to bring out thequantum physics that has been active behind the scenes to the front stage, and to make use of quantum properties to realize technologies that could not be achieved with existing technologies.
• Thinker — Thinker provides sales of proximity sensors and proposed solutions using these products.
• Orbital Lasers — Orbital is a space tech company that provides space debris business to remove debris and a satellite LiDAR business to provide surface data.

Portfolio highlights

• Todoker — Todoker is a baggage delivery convenient service providing company.
• CREO Bioscience — Cleo Bioscience is a Biotechnology company.
• Fabric Tokyo — FABRIC TOKYO is a Japanese startup provides a direct-to-consumer custom-made apparel brand. (former-company name Lifestyle Design Co., Ltd.). It enables customers to save their sizes, idea fabrics, and favorite designs, allowing them to make their original clothing later.FABRIC TOKYO was founded in 2012 by Yuichiro Mori and is based in Tokyo,Japan.

Portfolio highlights

• CastBio — Castbio specializes in antibody-drug conjugate-based drug discovery research and development. Along with medications, it also creates research reagents, medical equipment, in vitro diagnostic items, and offers drug discovery consulting.
• Illumi Medical — Illumi Medical is a manufacturing company that produces medical equipment and devices for the healthcare sector.
• Reborna Biosciences — Reborna Biosciences provides research and development in the field of genetic diseases. The company develops therapeutic options for area of unmet medical needs in genetic rare disease. The company's technology enables low-molecular compounds to target ribonucleic acid. The company provides new disease-modifying drugs for patients sufferingfrom rare genetic diseases including spinal muscular atrophy.

Portfolio highlights

• Metro Weather — Metroweather is a venture from Kyoto University that develops a high-performance Doppler lidar that measures the direction and speed of wind several tens of kilometers away from minute movements of fine particles in the atmosphere. We aim to contribute to the safety of the sky by completing a three-dimensional wind map, which has never beenrealized,based on years of research at the Kyoto University Research Institute for Sustainable Areas.
• Good News — Good News is a staffing agency that provides recruitment, public relations, and human resource management services.
• Okuma Diamond Device — Ookuma Diamond Device Co., Ltd. | Creating a next-generation semiconductor industry from Japan, driven by the mission to support the decommissioning of Fukushima Daiichi Nuclear Power Plant.

Portfolio highlights

• Sagri — Sagri is developing agriculture software for experienced farmers.
• Good News — Good News is a staffing agency that provides recruitment, public relations, and human resource management services.
• Rehabilitation 3.0 — Rehabilitation 3.0 focuses on a preventive medical system that provides AI assessment and tracking on health, exercise, mood, and wellness.

Portfolio highlights

• AI Silk — AI Silk are innovative conductive fibers produced with a dyeing technique. By using natural silk and giving conductivity to the fiber itself, They have succeeded in producing electrodes that reduce some of the risks and challenges of conventional medical electrodes, which can cause discomfort,skin and in vivo inflammation, and measurement failuredue to sweat or other elements. Their brand, AI Silk, is a new material that has strong and diverse application potential, even beyond the health / medical field.
• Logiless — Logiless is a cloud type all-in-one software dedicated to net shop. Since both orders and stocks can be managed together in a logical manner, efficiency of operations can be realized at low cost.
• ARCS — ARCS specializes in developing assisted reproductive medical devices using robotics and artificial intelligence technology.

Portfolio highlights

• Caguuu — Caguuu offers high-quality designer furniture at affordable prices, through e-commerce, eliminating middlemen and store operating costs.
• QREATION — QREATION is a digital intellectual property studio specializing in producing a wide range of popular content that originates primarily from social media platforms. The company focuses on creating high-quality short-form entertainment, including short dramas, comedy sketches, and variety shows.
• ARCS — ARCS specializes in developing assisted reproductive medical devices using robotics and artificial intelligence technology.

Portfolio highlights

• Recho — Recho’s voice AI solutions must offer some unique features. Recho has a mission to "create the future of communication" and provides the VoiceAI platform and its application, Voice Agent.
• Pliant — Pliant makes the latest generation of corporate credit cards that adapt perfectly to business processes and needs.
• Captain Fresh — Captain Fresh is a freshwater fish and seafood supply chain platform. Captain Fresh is a B2B marketplace leveraging technology to deliver the fastest harvest-to-retail in the industry. The company focuses on aggregating the fragmented retail demand across the country and linking them to the small fishermen and farmers throughout the Indian coast.The company was founded in 2019 and is based in Bengaluru, India.

Portfolio highlights

• ElleThermo — elleThermo aims to implement Semiconductor-Sensitised Thermal Cells (STCs), an energy conversion technology that can generate electricity from unused waste heat above room temperature.
• Aeterlink — Aeterlink is a wireless device maker and developer. They applied their technology to fields such as FA, robots, smart houses, and medicine and developed practical level technologies such as elemental technology that can wirelessly supply power.
• Nanofiber Quantum Technologies — Discover how NanoQT builds the foundation for scalable quantum computing with nanofiber cavity-QED technology and high-fidelity quantum connectivity.

Portfolio highlights

• Surv Biopharma — Surv Biopharma develops a drug discovery platform that facilitates research and development of veterinary drugs and pharmaceutical products.
• Metagen Therapeutics — Metagen Therapeutics is a Drug discovery and medical business company which utilizes microbiome science.
• Restore Vision — Restore Vision is a startup based in Japan aiming to develop a visual restoration gene therapy.

Portfolio highlights

• Tres Alchemix — Tres Alchemix is an AI-driven biotechnology company focused on accelerating drug discovery, predicting drug efficacy, and developing novel therapeutic compounds using advanced machine learning and data-driven approaches.
• Pestalozzi Technology — Pestalozzi Technology is a development and provision of educational products in the fields of physical education and club activities.
• Gel-Coat Biomaterials — Gel-Coat Biomaterials is a biotechnology company that develops innovative bio-based materials and new medical technologies.

Portfolio highlights

• digzyme — Digzyme is a research and development platform for creating, discovering, and evaluating new enzyme-catalyzed reactions by bioinformatics.
• Zehitomo — Zehitomo is an Japanese online platform that enables user to hire local service professionals, from photographers to personal trainers.
• MyDearest — MyDearest is a Full dive product planning and development company

Portfolio highlights

• Ashirase — Ashirase is a developer of a walking navigation system for the visually challenged. The company assists visually impaired people in walking independently. This also allows the user to have more attention to spare for audible warnings in their environment. It includes voice input and guidance via a smartphone app. A vibration interface is attachedto their shoes.
• Ken Robotec — Ken Robotec is a construction company that provides labor-saving solutions.
• MaterialGate — MaterialGate focuses on single-molecule dielectrics, developing technologies for devices with better electronic characteristics.

Portfolio highlights

• Emole — Emole is a platform that connects content creators with viewers through short drama content, offering a variety of engaging stories.
• Loglass — Loglass offers corporate intelligence to enhance business management.
• GenerativeX — GenerativeX provides AI app development, consulting, and generative model development.

Portfolio highlights

• Letara — Letara operates a space technology platform with the intention to serve a logistics network covering the solar system. The company produces hybrid propulsion engines for small spacecraft, promoting groundbreaking advances in space propulsion with high thrust, safe, and inexpensive propulsion system technology.
• Akari Hosho — Akari Hosho provides a group of trusted professionals, including lawyers and judicial scriveners. Akari Hosho provides a guarantee service.
• Black Cat Carnival — Black Cat Carnival Inc. is a communication service development company.

Portfolio highlights

• Fondi — fondi is a completely new English conversation communication service that allows you to live a virtual communal life with the world.
• Taian — Taian, which specializes in bridal industry services and software. They also provide ''Concept Marry,'' which allows couples to design invites and seating charts that match their wedding theme, as well as display guest information on Oiwaii.
• Knowledge Work — Knowledge Work specializes in the development and sales of software for companies.

Portfolio highlights

• Mydawa — MYDAWA is here to ensure that every Kenyan can get quality, secure and affordable medicine and wellness products online
• Helium Health — Helium Health empowers healthcare providers in Africa with digital tools, financing solutions, and data partnerships. Learn more about our innovative solutions.
• Revital Healthcare — Revital Healthcare is a manufacturer of medical devices and disposables for hospitals and other medical laboratories. It offers single-use syringes, needles, re-use prevention syringes and auto-disable syringes which helps in reducing the transmission of HIV and other blood-borne diseases along with infusion sets, blood transfusion sets and bloodcollection tubesThe company was established in 2006 and is headquartered in Kilifi, Kenya.

Portfolio highlights

• ThinkCyte — ThinkCyte provides single-cell analysis for research, diagnostics, and therapeutics with an integrated multidisciplinary approach.
• NodeX — We build open-source embedded software and cloud tools to help developers build secure IoT products, simply. By leveraging decentralized identity and h/w root of trust technology, IoT security platform "UNiD" enables developers to automate device management and easily build secure data pipeline between every devices and the cloud.
• CMerTV — CMer TV is a platform that connects advertisers with newspapers, magazines, and specialized media by video

Portfolio highlights

• Helpfeel — Our vision is to make saving, sharing, and exploring ideas as natural as breathing. On this journey we're humbled to be helping millions around the world from solo makers to university research labs, from gamers to pro designers, and large to small teams like ours.
• HACARUS — We make AI work, where common Big Data aproaches fail. Get explainable results, even from small data amounts. Available on the cloud or as embedded devices.

Portfolio highlights

• 17LIVE — Flip action technology, connect the world together; integrate instant audio and video into life, and create a new generation of action audio and video. No matter where you are, in any corner of the world, you can connect with the world anytime, anywhere through the 17LIVE platform, show your talent and enthusiasm, realize your dreams, and createyour own wonderful life.
• DriveX — DriveX is a consulting firm that helps in creating new businesses using AI solutionst.
• Linkage — Linkage is a Online health support business and Online specific health guidance.

Portfolio highlights

• Fager — Fager is an agriculture firm specializing in promoting decarbonization projects, agricultural carbon production, and sales.
• Shippio — Shippio is a service that enables a wide range of collective international logistics arrangements and management solutions via web.The platform features full-service export and import solutions for various international transportation needs; a special dashboard designated for import and export business, shipment, cost analysis, and invoicemanagement; and documentation support.
• Power Wave — Power Wave seeks a carbon-neutral world using wave technology for wireless power, tackling global warming and fuel depletion.

Portfolio highlights

• OptQC — OptQC commercializes cutting-edge optical quantum computing technologies developed by the Furusawa-Endo Laboratory. Because optical quantum computers are more scalable than superconducting and other quantum computing implementations, OptQC's optical quantum computers should reach this scale. They also have benefits like faster processing andreduced power consumption, which makes optical quantum computers a possible long-term pinnacle of quantum technology.
• Triorb — Triorb is a technology company that specializes in robot mobility development with the help of software and hardware solutions.
• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.

Portfolio highlights

• Wejo — We unlock limitless possibilities with connected vehicle data
• Tier IV — Tier IV is a federated academic startup embracing research and development of intelligent vehicles.Founded in December 2015, Tier IV has led the development of open-source software for self-driving technology, also known as Autoware, and applied it for the proof of concept of last-mile driverless mobility and logistics. Tier IV aspires to achieve“Democratization of Intelligent Vehicles”, where any individuals and organizations can contribute to a grander vision of future intelligent vehicles, leading to a better society in which all the people receive new spatio-temporal values.
• Zego — Zego is a commercial motor insurance provider that powers opportunities for businesses, from entire fleets of vehicles to self-employed drivers and riders. It combines best-in-class technology with sophisticated data sources to offer insurance products that save businesses time and money. Since its inception, Zego has believed that the problemwith traditional insurance is that it holds businesses back. It’s too expensive and time consuming, and it no longer suits businesses who use vehicles to earn money. Zego’s products represent a solution to this problem for businesses based across the UK, Europe and beyond.

Portfolio highlights

• NovAccel — NovAccel operates as a deep tech company, ensure a stable supply of medical radioisotopes.
• Sonire Therapeutics — Sonire Therapeutics provides High-Intensity Focused Ultrasound treatment for cancer.
• Neusignal Therapeutics — Neusignal Therapeutics is a medical company that develops therapeutic medicines for dementia and psychiatric illnesses.

Portfolio highlights

• Blue Laser Fusion — Blue Laser Fusion is a commercial fusion company. Blue Laser Fusion is a laser startup to commercialize laser fusion by inventing its own laser and fusion reactor.
• Alloyed — Alloyed delivers cutting-edge innovation in materials science, additive manufacturing, and advanced metallurgy. Explore our technologies and career opportunities.
• Nanofiber Quantum Technologies — Discover how NanoQT builds the foundation for scalable quantum computing with nanofiber cavity-QED technology and high-fidelity quantum connectivity.

Portfolio highlights

• avatarin — avatarin develops next-generation mobility and human augmentation platforms.
• ALI Technologies — Aerial Lab Industries focuses on research and development of UAV (unmanned miniature aircraft).
• 3D Printing Corporation — 3D Printing Corporation provides 3D printing technology solutions.

Portfolio highlights

• Yukai Engineering — YUKAI Engineering - THE ROBOT COMPANY

Portfolio highlights

• Ubitus — As cloud gaming enablers, Ubitus' GPU virtualization, Streaming technology and hybrid cloud deployment can serve different kinds of solutions for Telco, Game companies to quick enter cloud gaming market. Moreover, Ubitus provide Global distribution and New Media content solution for new media studio and fashion brand to help them distribute rich media contents worldwide.
• Drivezy — Own the Experience, not the Car
• Address — ADDress is a provider of co-living spaces in both urban and rural areas, enabling people to live in a range of luxurious residences at fixed prices.

Portfolio highlights

• Morus — Morus is a university-based biotech startup developing functional food ingredients from silkworms to address global health and nutrition challenges.
• QunaSys — Quantum physics is a relatively new field built since the beginning of the 20th century, but we have used MRI (nuclear magnetic resonance equipment) and lasers used for close examinations in hospitals, and semiconductors mounted on computers. Supports the technology that supports the daily life of people.QunaSys was established to bring out thequantum physics that has been active behind the scenes to the front stage, and to make use of quantum properties to realize technologies that could not be achieved with existing technologies.
• Metagen Therapeutics — Metagen Therapeutics is a Drug discovery and medical business company which utilizes microbiome science.

Portfolio highlights

• Morus — Morus is a university-based biotech startup developing functional food ingredients from silkworms to address global health and nutrition challenges.
• Epicbase — Epicbase is an AI-based automatic voice transcription service based on voice recognition technology.
• Somewhere — Somewhere is engaged in the travel and transportation business.

Portfolio highlights

• Kinish — Kinish is a company leading a revolution in dairy products. To achieve environmentally friendly and delicious dairy products, we are developing a special rice variety that produces milk proteins.
• Kwahuu Ocean — Kwahuu Ocean develops sustainable squid farming systems.
• Spine Chronicle — Spine chronicle is a medical device manufacturing firm that specializes in developing orthopedic medical equipment.

Portfolio highlights

• Anaguma — Anaguma handles business development based on the philosophy of helping people with a sustainable structure. The company's business objective is to eliminate concerns about purchases and reservations, and it delivers before-sales social networks. It also provides matching services exclusively for housekeepers' personal contracts. Thecompany also offers influencer marketing services with a focus on removing waste completely from advertising and realizing a world in which good products can be sold regardless of advertising costs.Anaguma was founded in January 2016 and is headquartered in Tokyo, Japan.
• Ageless — Ageless is a staffing agency that provides human resources-related services primarily to middle-aged and senior citizens.
• Forest — Forest Co., Ltd. operates as an e-commerce aggregator, seeks to identify sustainable, high-quality products and brands that embrace the spirit of Japan and help them grow and enter the global market by using the power of technology.

Portfolio highlights

• KAUCHE — KAUCHE is a social commerce app. They provide services for online and mail-order retail shops. Their customers' inquiries are addressed through phone, email, and online applications.
• Shippio — Shippio is a service that enables a wide range of collective international logistics arrangements and management solutions via web.The platform features full-service export and import solutions for various international transportation needs; a special dashboard designated for import and export business, shipment, cost analysis, and invoicemanagement; and documentation support.
• NaLaLys — NaLaLys is a business consulting firm that provides management, distribution, research, and consulting services.

Portfolio highlights

• HACARUS — We make AI work, where common Big Data aproaches fail. Get explainable results, even from small data amounts. Available on the cloud or as embedded devices.
• HekaBio — HekaBio connects world-leading healthcare innovations to unmet medical needs in the Asia Pacific, with broad category development expertise in pharma, medical device, in-vitro diagnostics, digital health, and cell & gene therapies.
• Jiksak Bioengineering — Jiksak Bioengineering is a biotechnology company. Jiksak Bioengineering provide an efficient screening service using a three-dimensional cell tissue "Nerve Organoid". We will mainly develop screening technologies specifically for neurodegenerative diseases and search for drugs that are effective for amyotrophic lateral sclerosis (ALS).

Portfolio highlights

• HOLO BIO — HOLO BIO is a research and technology firm that employs biological breeding techniques to address the food challenges faced by humanity.

Portfolio highlights

• Amptalk — Amptalk is a software development firm specializing in operating automatic transcription and analysis of online business negotiations.
• Grafenary — Graphenary creates unique graphene optical devices using graphene materials with a variety of remarkable features.
• NanoFrontier — NanoFrontier continues to market technologies that are widely available and incredibly inexpensive.

Portfolio highlights

• Resource Chemical — Resource Chemical develops CO2 into high-performance plastics that do not pollute the environment. The company's headquarters are in Berkeley, California.
• Albatross Technology — Albatross Technology is a technology company that develops offshore renewable energy devices and floating offshore wind turbines.
• TKG Therapeutics — Tokyo Nucleic Acid Synthesis is a pharmaceutical company that focuses on developing nucleic acid drugs using new-age medical technology.

Portfolio highlights

• Medii — Medii provides a physician sharing service for hospitals.
• digzyme — Digzyme is a research and development platform for creating, discovering, and evaluating new enzyme-catalyzed reactions by bioinformatics.
• viviane — viviane is running Japan's best video streaming guide, 1Screen.

Portfolio highlights

• Mined — Mined is a marketplace that provides online lessons in various subjects for elementary school students. Mind develops and operation of education-related services.
• PartnerProp — PartnerProp is a PRM tool with outstanding potential and a wide variety of capabilities that resolves all partner business difficulties.
• Takumi Giken Kogyo — Takumi Giken Kogyo is a price technology developer to help parts manufacturers quickly identify acceptable product prices. Takumi Giken Kogyo assists in estimate calculation and product function through AI drawing search and repeat project determination function, enabling manufacturers with flexible customization of product functions based oncustomer requirements.

Portfolio highlights

• KOMPEITO — Office de Yasai is an online platform that enables users to order and get vegetables delivered to their offices. The platform’s operations are based in Tokyo, Japan.
• Towing — Towing is an agricultural company that provides farming, manufacturing, and recycling services.
• Metro Weather — Metroweather is a venture from Kyoto University that develops a high-performance Doppler lidar that measures the direction and speed of wind several tens of kilometers away from minute movements of fine particles in the atmosphere. We aim to contribute to the safety of the sky by completing a three-dimensional wind map, which has never beenrealized,based on years of research at the Kyoto University Research Institute for Sustainable Areas.

Portfolio highlights

• Alumnote — The alumni association management software developed by Alumnote allows schools to manage their alumni associations online. The focus of the company is to undertake loyalty building and marketing for potential donors such as graduates and provides digital tools, and supports the execution of donation acquisition.
• Equmenopolis — Equmenopolis is an information services company that specializes in conversational AI agent platforms and application developments.
• Mechano Cross — Mechano Cross is a mechanical company that offers mechanochemical organic synthesis technology for solution reactions.

Portfolio highlights

• Cizucu — Cizucu is a stock photo community that helps creators and brands to create photos.
• HOLO BIO — HOLO BIO is a research and technology firm that employs biological breeding techniques to address the food challenges faced by humanity.
• RadioNano Therapeutics — RadioNano Therapeutics is developing innovative drugs for Boron Neutron Capture Therapy (BNCT), a type of radiation therapy that utilizes the nuclear reaction between thermal neutrons and boron-10 (¹⁰B) to destroy cancer cells by releasing alpha particles and lithium nuclei.

Portfolio highlights

• Tryeting — TRYETING provides an AI platform that integrates various types of software. One of the strengths of the company is materials informatics, a field that applies the techniques of informatics, such as AI and big data, to materials. This approach can significantly speed the development of new materials.
• TopoLogic — TopoLogic designs and manufactures heat flow sensors, thermoelectric conversion devices, and topological and novel spintronics materials.
• Sotas — Sotas provides services to chemical trading companies and bridges the gap between raw material producers and consumers.

Portfolio highlights

• FELIQS — FELIQS is a preclinical-stage start-up company established based on the robust science from molecular pathobiology, department of pharmaceutical science, Kyushu university.
• ATOMica — ATOMica is a co-working space and business management company for conference rooms, event venues, circles, and schools. The company uses coworking spaces as HUBs to provide services that maximize individuals' power. It can be used for a variety of purposes, including coworking space, shared office space, meetings, events, and web seminars. Itis also possible to use it only once. They plan and run local communities that bring together a diverse range of people, including students, workers, businesses, universities, and governments.
• OPTEMO — OPTEMO develops and supplies sales technology that allows businesses and customers to connect through a website.

Portfolio highlights

• AceRNA Technologies — AceRNA contributes to regenerative medicine and drug discovery through the discovery of novel miRNA functions. It began operation in April 2018, with its headquarters in Kyoto in Japan.
• Epicbase — Epicbase is an AI-based automatic voice transcription service based on voice recognition technology.
• Go Visions — Go Visions engages in the edutainment tech for children and human resources services.

Portfolio highlights

• F.MED — F.MED is a manufacturing company that designs and develops robotic microsurgical devices for the healthcare industry.
• BioPhenoMA — BioPhenoMA develops an AI-powered platform for detecting ultra-trace proteins that helps accelerate new drug discovery phases.
• Spiral — Spiral is a game changer in providing autonomous drone solutions for indoor environments, most notably during non-GPS situations.

Portfolio highlights

• GooPass — GooPass is a subscription-based camera equipment rental platform that offers users cameras, interchangeable lenses, and drones. It also allows users to buy or rent photography equipment by reserving it online.
• Tenchijin — Tenchijin is optimiz human civilization using space big data.
• ORENDA WORLD — ORENDA focuses on developing high-definition 3D simulation systems that apply gamification and real-time rendering technology.

Portfolio highlights

• Modalis Therapeutics — Modalis Therapeutics Corporation is an biotech company focusing on developing transformative therapeutics for unmet medical needs using its proprietary technologies on CRISPR and protein engineering platforms. The company has a strong foundation on intellectual property licensed from the University of Tokyo.
• DiscGenics — DiscGenics is focused on developing regenerative therapies that alleviate pain and restore function in patients with degenerative diseases of the spine.