Top 50 Life Science Startup Investors in Japan (July 2026)

Portfolio highlights

• Caguuu — Caguuu offers high-quality designer furniture at affordable prices, through e-commerce, eliminating middlemen and store operating costs.
• Diggle — DIGGLE is a service that provides fundamental management accounting management on the cloud called fraud management. It is possible to reduce the mistakes and man-hours of the fraud management task and easily carry out the fraud management task even if it is not an expert in finance or accounting.DIGGLE covers budget creation work and budgetrecord comparison work, especially in the foreman management work. In the budget creation work, the KPI and the budget are automatically created by inputting the target numerical value to the preset parameters utilizing the budget generator function, while the forecast contrasting work is made up of the financial information, non-financial information It is easy to calculate by simply entering the numerical value, and it is possible to carry out calculation of the forecast contrast.
• Instalimb — Instalimb is the world's first 3D printing prosthesis business.

Portfolio highlights

• Etaily — Etaily provides e-commerce and retail solutions in the Philippines, enabling brands with end-to-end services, from store management to fulfillment.
• Fermelanta — Fermelanta produces rare plant-based ingredients through microbial fermentation. It engineers a cell to build a biosynthetic pathway of target molecules with gene transfer and disruption.
• Neusignal Therapeutics — Neusignal Therapeutics is a medical company that develops therapeutic medicines for dementia and psychiatric illnesses.

Portfolio highlights

• Welyco — Welyco is an information technology company.We operate smart restaurant "solto". Utilize IT to realize efficient and diverse restaurant management.
• Reborna Biosciences — Reborna Biosciences provides research and development in the field of genetic diseases. The company develops therapeutic options for area of unmet medical needs in genetic rare disease. The company's technology enables low-molecular compounds to target ribonucleic acid. The company provides new disease-modifying drugs for patients sufferingfrom rare genetic diseases including spinal muscular atrophy.
• Fabric Tokyo — FABRIC TOKYO is a Japanese startup provides a direct-to-consumer custom-made apparel brand. (former-company name Lifestyle Design Co., Ltd.). It enables customers to save their sizes, idea fabrics, and favorite designs, allowing them to make their original clothing later.FABRIC TOKYO was founded in 2012 by Yuichiro Mori and is based in Tokyo,Japan.

Portfolio highlights

• Imiron — Imiron the process and tools used for modeling mathematical behavior in order to comprehend its fundamentals.
• Dioseve — Dioseve is providing novel possibilities for all life.
• CULTA —

Portfolio highlights

• Alxtal — Alxtal is a tech company who optimize the development, design, and manufacturing processes of the manufacturing industry with IT and AI.
• Direava —
• Zerodoor HD — Zerodoor HD specializes in digital transformation in constructing industry.

Portfolio highlights

• Mui Lab — Mui is an aesthetically-pleasing wooden IoT device connected to a cloud service. By accessing information through natural wood, we can rethink a new type of lifestyle.
• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.
• Fermelanta — Fermelanta produces rare plant-based ingredients through microbial fermentation. It engineers a cell to build a biosynthetic pathway of target molecules with gene transfer and disruption.

Portfolio highlights

• LQUOM — QWAVE offers cryptography communication technology.
• Orbital Lasers — Orbital is a space tech company that provides space debris business to remove debris and a satellite LiDAR business to provide surface data.
• Toregem BioPharma — Toregem BioPharma is a startup from Kyoto University that develops a treatment for congenital adentia. Toregem BioPharma is headquartered in Kyoto, Japan.

Portfolio highlights

• CastBio — Castbio specializes in antibody-drug conjugate-based drug discovery research and development. Along with medications, it also creates research reagents, medical equipment, in vitro diagnostic items, and offers drug discovery consulting.
• 3DC — 3DC develops and manufactures a new carbon material, graphene meso sponge (GMS), for electrodes in next-generation batteries, capacitors, fuel cells and other energy storage and generation devices.
• Formas.AI — Formas.AI is a multi-modal, AI-powered design platform specifically built for architects, designers, and educators to generate and visualize creative architectural concepts.

Portfolio highlights

• CaTe —
• FunPep — FunPep is an Industry-university collaboration bioventure company.
• Triorb — Triorb is a technology company that specializes in robot mobility development with the help of software and hardware solutions.

Portfolio highlights

• Menou — MENOU specializes in AI technology and sensing technology. It features a graphical image identification modeler software.
• Restore Vision — Restore Vision is a startup based in Japan aiming to develop a visual restoration gene therapy.
• Movus Technologies — Movus Technologies Indonesia is automotive company that provides car ownership rental services.

Portfolio highlights

• CaTe —
• Alxtal — Alxtal is a tech company who optimize the development, design, and manufacturing processes of the manufacturing industry with IT and AI.
• EISHIN — EISHIN is a technology company that specializes in pet tech business, recruitment consulting, website creation, and development services.

Portfolio highlights

• Molmir — Molmir is a biotech company that conducts research and develops treatments for intractable diseases based on sensing technology.
• LEP —
• Akari Hosho — Akari Hosho provides a group of trusted professionals, including lawyers and judicial scriveners. Akari Hosho provides a guarantee service.

Portfolio highlights

• Recerqa — Recerqa is a supply chain management SaaS that utilizes advanced development technology and AI to improve the purchasing, inventory, and sales management experiences.
• Mign — Mign offers a generative AI-related SaaS solutions for the construction and real estate fields.
• Henry — Henry develops and provides a cloud-based electronic medical record and receipt system for small and medium-sized hospitals.

Portfolio highlights

• Triorb — Triorb is a technology company that specializes in robot mobility development with the help of software and hardware solutions.
• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.
• Solaris — Solaris commercializes, manufactures, and sells soft robotics using pneumatic artificial muscles. Solaris was founded in 2017 and was headquartered in Tokyo, Japan.

Portfolio highlights

• Eco-Pork — Eco-Pork is a co-creation solution farm that supports farmers' food productivity improvement. It is connecting the pig and technology, pork ( Pork ) new business ecosystems ( Ecosystem By building a), in the pork growing demand around the world, to get the most out of the food supply capacity is finite.
• Grafenary — Graphenary creates unique graphene optical devices using graphene materials with a variety of remarkable features.
• Orbital Lasers — Orbital is a space tech company that provides space debris business to remove debris and a satellite LiDAR business to provide surface data.

Portfolio highlights

• Tacoms — CAMEL is a service that allows you to easily manage orders from multiple food delivery / takeout services on a single tablet.
• Any Style —
• Smile Robotics — Smile Robotics provides Service Robots in Japan.

Portfolio highlights

• Pestalozzi Technology — Pestalozzi Technology is a development and provision of educational products in the fields of physical education and club activities.
• Gel-Coat Biomaterials — Gel-Coat Biomaterials is a biotechnology company that develops innovative bio-based materials and new medical technologies.
• CoreTissue BioEngineering — CoreTissue BioEngineering is a development of an artificial ligament for reconstruction of the anterior cruciate ligament in Japan.

Portfolio highlights

• Akari Hosho — Akari Hosho provides a group of trusted professionals, including lawyers and judicial scriveners. Akari Hosho provides a guarantee service.
• Black Cat Carnival — Black Cat Carnival Inc. is a communication service development company.
• Carbon CryoCapture — Carbon CryoCapture specializes in the carbon dioxide separation systems aimed at creating economically viable, energy-efficient, and genuinely sustainable CO2 separation and recovery technologies. The company is dedicated to deploying cost-effective, efficient systems for CO2 capture that integrate smoothly with current infrastructures, all whileenhancing energy consumption and production. This enables clients to attain zero emissions throughout the development and application of resources.

Portfolio highlights

• NovAccel — NovAccel operates as a deep tech company, ensure a stable supply of medical radioisotopes.
• AstroX — AstroX is a private space startup company that develops satellite launch vehicles for space development. It utilizes the rockoon method for developing launch vehicles and small rockets to help clients easily use space.
• Sonire Therapeutics — Sonire Therapeutics provides High-Intensity Focused Ultrasound treatment for cancer.

Portfolio highlights

• Grafenary — Graphenary creates unique graphene optical devices using graphene materials with a variety of remarkable features.
• SecureNavi — SecureNavi offers automation tools for the information security management system. It reduces conventional analogue operations using excel and word. For inquiries, telephone numbers and physical addresses are available on their website.
• NanoFrontier — NanoFrontier continues to market technologies that are widely available and incredibly inexpensive.

Portfolio highlights

• BitBiome — BitBiome is a microbiome analysis company that aims to discover and understand disease-linked microorganisms. Its, single-cell whole-genome analysis platform specifically targets microbes and can be used on uncultured, raw samples, providing unprecedented strain-level quantitative and functional insights.THe company was founded in 2018 and isbased in Japan.
• TopoLogic — TopoLogic designs and manufactures heat flow sensors, thermoelectric conversion devices, and topological and novel spintronics materials.
• Global Equipment Services — As a strategic partner to developers of multi-sector products, Averna provides innovative automated testing tool and quality assurance solutions.

Portfolio highlights

• Eco-Pork — Eco-Pork is a co-creation solution farm that supports farmers' food productivity improvement. It is connecting the pig and technology, pork ( Pork ) new business ecosystems ( Ecosystem By building a), in the pork growing demand around the world, to get the most out of the food supply capacity is finite.
• Equmenopolis — Equmenopolis is an information services company that specializes in conversational AI agent platforms and application developments.
• Surv Biopharma — Surv Biopharma develops a drug discovery platform that facilitates research and development of veterinary drugs and pharmaceutical products.

Portfolio highlights

• SODEN — SODEN is a technology company that develops and sells electric vehicle chargers and their management software.
• Voicetep —
• Kick Space Technologies —

Portfolio highlights

• Ashirase — Ashirase is a developer of a walking navigation system for the visually challenged. The company assists visually impaired people in walking independently. This also allows the user to have more attention to spare for audible warnings in their environment. It includes voice input and guidance via a smartphone app. A vibration interface is attachedto their shoes.
• Ken Robotec — Ken Robotec is a construction company that provides labor-saving solutions.
• MaterialGate — MaterialGate focuses on single-molecule dielectrics, developing technologies for devices with better electronic characteristics.

Portfolio highlights

• FELIQS — FELIQS is a preclinical-stage start-up company established based on the robust science from molecular pathobiology, department of pharmaceutical science, Kyushu university.
• ATOMica — ATOMica is a co-working space and business management company for conference rooms, event venues, circles, and schools. The company uses coworking spaces as HUBs to provide services that maximize individuals' power. It can be used for a variety of purposes, including coworking space, shared office space, meetings, events, and web seminars. Itis also possible to use it only once. They plan and run local communities that bring together a diverse range of people, including students, workers, businesses, universities, and governments.
• OPTEMO — OPTEMO develops and supplies sales technology that allows businesses and customers to connect through a website.

Portfolio highlights

• F.MED — F.MED is a manufacturing company that designs and develops robotic microsurgical devices for the healthcare industry.
• BioPhenoMA — BioPhenoMA develops an AI-powered platform for detecting ultra-trace proteins that helps accelerate new drug discovery phases.
• Spiral — Spiral is a game changer in providing autonomous drone solutions for indoor environments, most notably during non-GPS situations.

Portfolio highlights

• GooPass — GooPass is a subscription-based camera equipment rental platform that offers users cameras, interchangeable lenses, and drones. It also allows users to buy or rent photography equipment by reserving it online.
• Tenchijin — Tenchijin is optimiz human civilization using space big data.
• ORENDA WORLD — ORENDA focuses on developing high-definition 3D simulation systems that apply gamification and real-time rendering technology.

Portfolio highlights

• Mydawa — MYDAWA is here to ensure that every Kenyan can get quality, secure and affordable medicine and wellness products online
• Helium Health — Helium Health empowers healthcare providers in Africa with digital tools, financing solutions, and data partnerships. Learn more about our innovative solutions.
• Africa Healthcare Network — Africa Healthcare Network (“AHN”) has established the first dialysis chain across Sub-Saharan Africa, providing high-quality, life-saving dialysis at affordable cost. AHN brings world-class technical expertise combined with developing world practical operating experience to a region in dire need of quality dialysis treatment. Dialysis is alife-saving treatment for patients with Acute Kidney Injury (AKI) and End-Stage Renal Disease (ESRD). The few hospitals that provide treatment operate centers that are slowly deteriorating while charging prohibitive prices. Additionally, the lack of trained professionals and limited capital investment in care for non-communicable diseases in Sub-Saharan Africa, dialysis centers are few and far between, causing patients to endure the high costs for travel to receive care. Those who cannot afford the costs of treatment and travel are resigned to death. Chronic Kidney Disease (CKD) and AKI are on the rise in the region due to strong epidemiologic factors, including increased urbanization leading to lifestyle diseases, other non-communicable diseases, HIV and other infections and toxins. Utilizing our network of executives/partners, we will secure high-quality equipment and train professionals to provide superior care. Our ability to source lowest cost consumables, operational efficiency and scale, will allow us to lower the cost to patients. The net result is increased access, higher quality and lower cost to patients, while maintaining profitability.AHN operates in Rwanda, Tanzania and Kenya.

Portfolio highlights

• TSK Corporation —
• IKOU — IKOU is an inclusive brand for babies and children that creates products valued by all users. The company's featured products include portable seats, bibs, and children's clothing products along with online services.
• Metro Weather — Metroweather is a venture from Kyoto University that develops a high-performance Doppler lidar that measures the direction and speed of wind several tens of kilometers away from minute movements of fine particles in the atmosphere. We aim to contribute to the safety of the sky by completing a three-dimensional wind map, which has never beenrealized,based on years of research at the Kyoto University Research Institute for Sustainable Areas.

Portfolio highlights

• GPx — GPx is a biotech company that revolutionizes remote chronic disease management with bloodless blood tests. It is dedicated to transforming the standard of care of cardiorenal diseases and enabling patients to better understand their condition, much like the continuous glucose monitor has transformed diabetes care.The company was founded in 2020and is based in Boston, Massachusetts.
• Epistra — Epistra accelerates research and development in life sciences.
• Activaid — Activaid owns and operates a social data platform for patients with inflammatory bowel disease. It allows patients to support and exchange information within the patient community with the same disease; provide information necessary for new drug development and matching to clinical trials that suits them; and improve medical treatment. YasuakiHasebe founded Activaid in 2018. It has its headquarters in Tokyo in Japan.

Portfolio highlights

• AMI — AMI Corp is engaged in medical consulting, medical device development and writing.
• Do. Sukasu — Do. Sukasu is a software company that specializes in the development of visual space perception ability for brain science approaches.
• HEAL-lll — HEAL-lll is a multifaceted firm that merges healthcare, technology, and gamification to promote individual and organizational well-being.

Portfolio highlights

• Mono.un — Mono.un provides users with opportunities to meet authors and collaborate on tales and specializes in bringing exciting experiences full of stories of Japanese culture to the world.
• Memory Lab — Memory Lab is a research laboratory that offers AI paper analysis and development solutions.

Portfolio highlights

• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.
• Hacobell — Hacobell is a logistics company that offers services in freight servicing, dispatch, and delivery.
• Power Wave — Power Wave seeks a carbon-neutral world using wave technology for wireless power, tackling global warming and fuel depletion.

Portfolio highlights

• Junten Bio — JUNTEN BIO is a company is to develop new technologies in the field of regenerative medicine.
• Chromocenter — Chromocenter is a next generation biopharmaceuticals Manufacturing company. It uses technologies such as artificial chromosome vectors, mainly for drug discovery such as medical pharmaceuticals
• Noile-Immune Biotech — Neurymune Biotech Co., Ltd. is a national cancer research center specializing in the development of cancer immunotherapies based on CAR-T cell therapy and a venture company from Yamaguchi University. They aim to be a leading company responsible for the next generation in the field of cancer immunotherapy.

Portfolio highlights

• CoA Nexus — CoA Nexus develops and operates a skillshare matching platform for human resource research and development.
• bestat — bestat is a developer of platforms for 3D data creation, management, and utilization using AI and offers digital twins services.
• Openverse Global — Openverse operates as a Layer 0 hub, providing a foundational framework for decentralized applications and services.

Portfolio highlights

• Alpha Fusion — Alpha Fusion Inc. is a clinical-stage startup committed to transforming cancer treatment through the design and development of powerful and precise radiopharmaceuticals.
• Chitose Group — CHITOSE GROUP is a family of biotechnology companies operating mainly in Southeast Asia and Japan with an aim of leaving mankind with an environment where they can live in abundance for over a thousand years. CHITOSE GROUP is creating new values in the fields of agriculture, medical, food, energy, chemistry and others through “Technologicaldevelopment capabilities in the biotechnology field by constantly promoting economic rationality” and “Business development capabilities for drawing a path towards commercialization by understanding the essence and limitations of biotechnology”.
• WaHa — WaHa's innovative atmospheric water generator creates sustainable water solutions from air. Experience pure water generation with the WaHa Vaporator system.

Portfolio highlights

• Thyas — Thyas Co. Ltd. provides preparations of regenerative immunocell therapy for cancer and infection.
• Regional Fish — Regional Fish provides seed, seedlings, aquaculture methods and fisheries services.
• Space Power Technologies — Space Power Technologies (SPT) was founded in 2019 as Japan's first start-up for “Spatial Transmission Wireless Power Transmission (WPT)”. We will harmonize elemental technologies cultivated through academics with people and society, and solve social issues related to power supply.

Portfolio highlights

• Ripcord — Ripcord is a robotics company that combines hardware and software robotics via an integrated SaaS offering. Its focus is on smart robotics digitization, smart content management with AI, and helping enable RPA and business processes.Ripcord is based in Hayward, California, and is backed by leading investors Kleiner Perkins Caufield & Byers,Google Ventures, Lux Ventures, Legend Star, and Apple Co-Founder Steve Wozniak.
• Rapidus — Rapidus is an Electronic component research, development, design, production, and sales that includes semiconductor elements and integrated circuits. Environmentally friendly, energy-saving semiconductors and semiconductor manufacturing technology are being researched and developed. Human resource development and training for the semiconductorsector.
• VALANX Biotech — VALANX Biotech is a site-specific protein conjugation platform to enable fast and cost efficient protein-drug-conjugates development.

Portfolio highlights

• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.
• TXP Medical — TXP Medical build a next-generation medical system through acute care.
• Startbahn — Startbahn develops Startrail, a sustainable and scalable blockchain infrastructure that assures the reliability, authenticity, and traceability of artworks.

Portfolio highlights

• D-Chain — D-Chain offers services related to IT development and production in the Web3 and Web2 fields.
• Rayout — Rayout is a business consulting company that provides creative content development, recruitment videos, and web production services.
• CAREER BIJIN — Career bijin is a total support company.

Portfolio highlights

• Helpfeel — Our vision is to make saving, sharing, and exploring ideas as natural as breathing. On this journey we're humbled to be helping millions around the world from solo makers to university research labs, from gamers to pro designers, and large to small teams like ours.
• HACARUS — We make AI work, where common Big Data aproaches fail. Get explainable results, even from small data amounts. Available on the cloud or as embedded devices.

Portfolio highlights

• Pulsora — Use Pulsora to centralize and automate ESG metrics collection, measure carbon emissions, prepare reports and disclosures, and track performance.
• Tier IV — Tier IV is a federated academic startup embracing research and development of intelligent vehicles.Founded in December 2015, Tier IV has led the development of open-source software for self-driving technology, also known as Autoware, and applied it for the proof of concept of last-mile driverless mobility and logistics. Tier IV aspires to achieve“Democratization of Intelligent Vehicles”, where any individuals and organizations can contribute to a grander vision of future intelligent vehicles, leading to a better society in which all the people receive new spatio-temporal values.
• Zego — Zego is a commercial motor insurance provider that powers opportunities for businesses, from entire fleets of vehicles to self-employed drivers and riders. It combines best-in-class technology with sophisticated data sources to offer insurance products that save businesses time and money. Since its inception, Zego has believed that the problemwith traditional insurance is that it holds businesses back. It’s too expensive and time consuming, and it no longer suits businesses who use vehicles to earn money. Zego’s products represent a solution to this problem for businesses based across the UK, Europe and beyond.

Portfolio highlights

• Spaceflux — As satellites become increasingly vital, Spaceflux tackles the growing challenges of orbital congestion and debris that put them at risk. Thanks to our proprietary global network of optical sensors, we provide data-driven space situational awareness services from LEO to Cislunar.
• Alloyed — Alloyed delivers cutting-edge innovation in materials science, additive manufacturing, and advanced metallurgy. Explore our technologies and career opportunities.
• UnaBiz — Based in Singapore, Taiwan and Japan, UnaBiz delivers end-to-end customised IoT solutions worldwide. Simple, cost-efficient & low maintenance

Portfolio highlights

• Medii — Medii provides a physician sharing service for hospitals.
• digzyme — Digzyme is a research and development platform for creating, discovering, and evaluating new enzyme-catalyzed reactions by bioinformatics.
• viviane — viviane is running Japan's best video streaming guide, 1Screen.

Portfolio highlights

• digzyme — Digzyme is a research and development platform for creating, discovering, and evaluating new enzyme-catalyzed reactions by bioinformatics.
• ARCS — ARCS specializes in developing assisted reproductive medical devices using robotics and artificial intelligence technology.
• Metagen Therapeutics — Metagen Therapeutics is a Drug discovery and medical business company which utilizes microbiome science.

Portfolio highlights

• Quants — Quants uses AI qualitative credit technology to provide financing services. The company creates Type 21, an artificial intelligence with a credit screening circuit that runs automatically. HIF aims to provide appropriate funds to corporations and individuals.
• avatarin — avatarin develops next-generation mobility and human augmentation platforms.
• 3D Printing Corporation — 3D Printing Corporation provides 3D printing technology solutions.

Portfolio highlights

• DriveX — DriveX is a consulting firm that helps in creating new businesses using AI solutionst.
• Linkage — Linkage is a Online health support business and Online specific health guidance.
• CI Partners — CI Partners mission is to "eliminate the word 'disability' from this country," and with the message "Everyone is a star."

Portfolio highlights

• NovAccel — NovAccel operates as a deep tech company, ensure a stable supply of medical radioisotopes.
• Storm Therapeutics — Targeting pathways that modify RNA to deliver novel cancer therapeutics.
• Sonire Therapeutics — Sonire Therapeutics provides High-Intensity Focused Ultrasound treatment for cancer.

Portfolio highlights

• HACARUS — We make AI work, where common Big Data aproaches fail. Get explainable results, even from small data amounts. Available on the cloud or as embedded devices.
• HekaBio — HekaBio connects world-leading healthcare innovations to unmet medical needs in the Asia Pacific, with broad category development expertise in pharma, medical device, in-vitro diagnostics, digital health, and cell & gene therapies.
• Jiksak Bioengineering — Jiksak Bioengineering is a biotechnology company. Jiksak Bioengineering provide an efficient screening service using a three-dimensional cell tissue "Nerve Organoid". We will mainly develop screening technologies specifically for neurodegenerative diseases and search for drugs that are effective for amyotrophic lateral sclerosis (ALS).

Portfolio highlights

• AceRNA Technologies — AceRNA contributes to regenerative medicine and drug discovery through the discovery of novel miRNA functions. It began operation in April 2018, with its headquarters in Kyoto in Japan.
• Epicbase — Epicbase is an AI-based automatic voice transcription service based on voice recognition technology.
• Flagellin — Flagellin is a pharmaceutical and medical industry.Development and sales of SaaS that supports sales and marketing of database and analysis services in the pharmaceutical and medical industries