Top 50 Biotechnology Startup Investors in Japan (July 2026)

Portfolio highlights

• Diggle — DIGGLE is a service that provides fundamental management accounting management on the cloud called fraud management. It is possible to reduce the mistakes and man-hours of the fraud management task and easily carry out the fraud management task even if it is not an expert in finance or accounting.DIGGLE covers budget creation work and budgetrecord comparison work, especially in the foreman management work. In the budget creation work, the KPI and the budget are automatically created by inputting the target numerical value to the preset parameters utilizing the budget generator function, while the forecast contrasting work is made up of the financial information, non-financial information It is easy to calculate by simply entering the numerical value, and it is possible to carry out calculation of the forecast contrast.
• Luxna Biotech — Luxana Biotech is established to contribute to medical treatment for suffering patients, .
• Link Therapeutics — Link Therapeutics specializes in developing therapeutic methods for targeting autoantibodies and identifying pathogenic autoantibodies.

Portfolio highlights

• CastBio — Castbio specializes in antibody-drug conjugate-based drug discovery research and development. Along with medications, it also creates research reagents, medical equipment, in vitro diagnostic items, and offers drug discovery consulting.
• 3DC — 3DC develops and manufactures a new carbon material, graphene meso sponge (GMS), for electrodes in next-generation batteries, capacitors, fuel cells and other energy storage and generation devices.
• Formas.AI — Formas.AI is a multi-modal, AI-powered design platform specifically built for architects, designers, and educators to generate and visualize creative architectural concepts.

Portfolio highlights

• Tacoms — CAMEL is a service that allows you to easily manage orders from multiple food delivery / takeout services on a single tablet.
• Any Style —
• Smile Robotics — Smile Robotics provides Service Robots in Japan.

Portfolio highlights

• Fermelanta — Fermelanta produces rare plant-based ingredients through microbial fermentation. It engineers a cell to build a biosynthetic pathway of target molecules with gene transfer and disruption.
• Atom — Atom is a humanoid robot built platform. Its bipedal, dual-armed robots are designed not just as industrial tools but as collaborators that expand human capability. By combining advanced Physical AI—environmental perception, judgment, and action planning—with robust robotic hardware, Atom is creating adaptive agents capable of working acrossdiverse settings to augment or, where appropriate, replace human labor. The company positions these robots as a next step in societal evolution: a new class of machines that learn and behave in human-like ways to advance productivity, safety, and quality of life.
• Link Therapeutics — Link Therapeutics specializes in developing therapeutic methods for targeting autoantibodies and identifying pathogenic autoantibodies.

Portfolio highlights

• JiMED — JiMED designs & develops AI based brain-computer interface for implant in ALS patients to improve communication.
• LQUOM — QWAVE offers cryptography communication technology.
• Toregem BioPharma — Toregem BioPharma is a startup from Kyoto University that develops a treatment for congenital adentia. Toregem BioPharma is headquartered in Kyoto, Japan.

Portfolio highlights

• NovAccel — NovAccel operates as a deep tech company, ensure a stable supply of medical radioisotopes.
• Sonire Therapeutics — SONIRE Therapeutics Inc. (SONIRE) is working on a next-generation high-intensity focused ultrasound (HIFU) therapy system that will employ acoustic engineering (ultrasound) technologies developed through cutting-edge academic research. SONIRE has been working on a next-generation high-intensity focused ultrasound (HIFU) treatment system as a noveltherapeutic modality with the goal of giving cancer patients and their families a new future.
• Neusignal Therapeutics — Neusignal Therapeutics is a medical company that develops therapeutic medicines for dementia and psychiatric illnesses.

Portfolio highlights

• CaTe —
• EISHIN — EISHIN is a technology company that specializes in pet tech business, recruitment consulting, website creation, and development services.
• Yokohama Vanilla — Yokohama Vanilla is a Company which operates Yokohama-based gift sweets brand.

Portfolio highlights

• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.
• TXP Medical — TXP Medical build a next-generation medical system through acute care.
• Startbahn — Startbahn develops Startrail, a sustainable and scalable blockchain infrastructure that assures the reliability, authenticity, and traceability of artworks.

Portfolio highlights

• JiMED — JiMED designs & develops AI based brain-computer interface for implant in ALS patients to improve communication.
• Grafenary — Graphenary creates unique graphene optical devices using graphene materials with a variety of remarkable features.
• Neusignal Therapeutics — Neusignal Therapeutics is a medical company that develops therapeutic medicines for dementia and psychiatric illnesses.

Portfolio highlights

• CaTe —
• FunPep — FunPep is an Industry-university collaboration bioventure company.
• NEXT NEW WORLD — NEXT NEW WORLD develops and manufactures natural products with low impact on the environment. It uses sustainable Japanese silk to manufacture apparel and cosmetic products.

Portfolio highlights

• LQUOM — QWAVE offers cryptography communication technology.
• Direava —
• Zerodoor HD — Zerodoor HD specializes in digital transformation in constructing industry.

Portfolio highlights

• Ginco — Ginco's goal is to Change the relationship between individuals and assets by making full use of block chain technology. The primary focus of Ginco, its cryptocurrency wallet app, is centered around dApp and the On-Chain function, and the company plans to expand its business in a multifaceted manner while watching trends in the ecosystemdevelopment. In the future, they were told that they have the possibility of developing with DEXs (decentralized exchanges).
• Scohia Pharma — Scohia Pharma is a biotech venture that will have both substantial research and development resources and be nimble enough to make decisions quickly, will strive to improve patient quality of life by providing patients and healthcare professionals with new therapeutic medications for renal, metabolic.
• Arrowsmith — Arrowsmith is committed to unlocking the full potential of bacteriophages to revolutionize the treatment of bacterial infectious diseases. Through transformative science, Arrowsmith strive to create a world free from the pain and fear caused by antimicrobial resistance.

Portfolio highlights

• Ashirase — Ashirase is a developer of a walking navigation system for the visually challenged. The company assists visually impaired people in walking independently. This also allows the user to have more attention to spare for audible warnings in their environment. It includes voice input and guidance via a smartphone app. A vibration interface is attachedto their shoes.
• Ken Robotec — Ken Robotec is a construction company that provides labor-saving solutions.
• MaterialGate — MaterialGate focuses on single-molecule dielectrics, developing technologies for devices with better electronic characteristics.

Portfolio highlights

• Triorb — Triorb is a technology company that specializes in robot mobility development with the help of software and hardware solutions.
• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.
• Solaris — Solaris commercializes, manufactures, and sells soft robotics using pneumatic artificial muscles. Solaris was founded in 2017 and was headquartered in Tokyo, Japan.

Portfolio highlights

• Mui Lab — Mui is an aesthetically-pleasing wooden IoT device connected to a cloud service. By accessing information through natural wood, we can rethink a new type of lifestyle.
• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.
• Fermelanta — Fermelanta produces rare plant-based ingredients through microbial fermentation. It engineers a cell to build a biosynthetic pathway of target molecules with gene transfer and disruption.

Portfolio highlights

• Imiron — Imiron the process and tools used for modeling mathematical behavior in order to comprehend its fundamentals.
• Dioseve — Dioseve is providing novel possibilities for all life.
• CULTA —

Portfolio highlights

• Menou — MENOU specializes in AI technology and sensing technology. It features a graphical image identification modeler software.
• Space BD — Space BD aims to become a one-stop shop to respond to all issues related to industrialization of space, and alleviate the work of businesses that are developing new technologies.
• Neusignal Therapeutics — Neusignal Therapeutics is a medical company that develops therapeutic medicines for dementia and psychiatric illnesses.

Portfolio highlights

• Cake.jp — Cake.jp operates "Cake.jp", a comprehensive cake delivery site.
• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.
• Fabric Tokyo — FABRIC TOKYO is a Japanese startup provides a direct-to-consumer custom-made apparel brand. (former-company name Lifestyle Design Co., Ltd.). It enables customers to save their sizes, idea fabrics, and favorite designs, allowing them to make their original clothing later.FABRIC TOKYO was founded in 2012 by Yuichiro Mori and is based in Tokyo,Japan.

Portfolio highlights

• Naorai — Naorai is a food and beverage firm that manufactures wine, beer, spirits, and non-alcoholic beverages.
• Dioseve — Dioseve is providing novel possibilities for all life.
• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.

Portfolio highlights

• MW — MW is a smart home solution company that develops smart residential physical AI, robotics, and home design services.
• InsightX — InsightX is a technology platform focused on empowering businesses by simplifying complex processes and enabling smarter, more personalized user experiences.
• Neusignal Therapeutics — Neusignal Therapeutics is a medical company that develops therapeutic medicines for dementia and psychiatric illnesses.

Portfolio highlights

• JiMED — JiMED designs & develops AI based brain-computer interface for implant in ALS patients to improve communication.
• Molmir — Molmir is a biotech company that conducts research and develops treatments for intractable diseases based on sensing technology.
• LEP —

Portfolio highlights

• Ripcord — Ripcord is a robotics company that combines hardware and software robotics via an integrated SaaS offering. Its focus is on smart robotics digitization, smart content management with AI, and helping enable RPA and business processes.Ripcord is based in Hayward, California, and is backed by leading investors Kleiner Perkins Caufield & Byers,Google Ventures, Lux Ventures, Legend Star, and Apple Co-Founder Steve Wozniak.
• Rapidus — Rapidus is an Electronic component research, development, design, production, and sales that includes semiconductor elements and integrated circuits. Environmentally friendly, energy-saving semiconductors and semiconductor manufacturing technology are being researched and developed. Human resource development and training for the semiconductorsector.
• VALANX Biotech — VALANX Biotech is a site-specific protein conjugation platform to enable fast and cost efficient protein-drug-conjugates development.

Portfolio highlights

• Akari Hosho — Akari Hosho provides a group of trusted professionals, including lawyers and judicial scriveners. Akari Hosho provides a guarantee service.
• Black Cat Carnival — Black Cat Carnival Inc. is a communication service development company.
• Pixie Dust Technologies — Pixie Dust Technologies is a developer of computational technologies, including its ultrasonic phased array system with which one can generate force in mid-air; transport things in mid-air without touching anything; target and deliver different sounds from person to person in a crowd; direct guide-dogs; and even apply this in agricultural farming.

Portfolio highlights

• Ababa — Ababa provides recruitment and employment solutions.
• CraftBank — CraftBank, Inc. is the start-up that operates online matching platform between constructors with having relations with 22k specialty constructors (10% coverage in the market). The company was succeeded in Management BuyOut in April 2021.
• Josh Collaboration — Josh Collaboration is a software company that provides mailing, fax transmission, and partner management services.

Portfolio highlights

• Grooves — grooves has been providing #1 Web applications for the recruiters as the web community to build to meet with each other for new business opportunities and possible partnerships in Japan since 2004. Now,there are more than 3,000 companies customers in Asiapacific.
• Turing — Turing develops and manufactures fully autonomous vehicles.
• Atom — Atom is a humanoid robot built platform. Its bipedal, dual-armed robots are designed not just as industrial tools but as collaborators that expand human capability. By combining advanced Physical AI—environmental perception, judgment, and action planning—with robust robotic hardware, Atom is creating adaptive agents capable of working acrossdiverse settings to augment or, where appropriate, replace human labor. The company positions these robots as a next step in societal evolution: a new class of machines that learn and behave in human-like ways to advance productivity, safety, and quality of life.

Portfolio highlights

• Kupando — Kupando is a biopharmaceutical company that develops agonists to stimulates innate immunity.
• Glycomine — We are developing a PMM2-CDG substrate replacement therapy. GLM101 is a mannose-1 phosphate treatment.
• Restore Vision — Restore Vision is a startup based in Japan aiming to develop a visual restoration gene therapy.

Portfolio highlights

• Recerqa — Recerqa is a supply chain management SaaS that utilizes advanced development technology and AI to improve the purchasing, inventory, and sales management experiences.
• Mign — Mign offers a generative AI-related SaaS solutions for the construction and real estate fields.
• Henry — Henry develops and provides a cloud-based electronic medical record and receipt system for small and medium-sized hospitals.

Portfolio highlights

• Vestwell — Vestwell is a digital savings platform redefining the way workplace plans are powered today.
• Lemon Cash — Lemon Cash is digital wallet with FIAT and crypto capabilities. End to end digital ecosystem for Latin America.
• Checkmate Pharmaceuticals — Empowering the immune system to beat back cancer

Portfolio highlights

• Neumo — Neumo is a musical education-based firm that offers pitch measurement courses, programs, consulting, and tests.
• RevolKa — RevolKa manufactures bio-products pharmaceuticals intended to serve the healthcare sector.
• Neros Technologies — Neros is vertically integrating production of unmanned defense systems in the United States, securing the autonomous supply chain. Are you with us?

Portfolio highlights

• BaseLaunch — We partner with scientists and entrepreneurs to help launch and grow exceptional biotech ventures, developing cutting-edge therapeutics.
• Beacon Biosignals — AI + EEG to change the way patients are treated for disorders of the brain.
• Innovent Biologics — Innovent Biologics, Inc. is a privately held biopharmaceutical company that is dedicated to the development and manufacturing of monoclonal antibodies to be marketed in China and elsewhere around the world. Innovent is funded by the venture arm of Fidelity, which is a major investment firm in the US, Lilly Ventures, and Suzhou bioBay. Theregistered capital is 30Million US Dollars. The founders and senior management team of Innovent have over 70 years of combined work experience in the discovery, development and manufacture of biologics in the US, Europe and worldwide and were involved in the launch of such products as Bexxar, Conbercept, Natrecor, Oncorine, Recombivax HB, and others.

Portfolio highlights

• 3DC — 3DC develops and manufactures a new carbon material, graphene meso sponge (GMS), for electrodes in next-generation batteries, capacitors, fuel cells and other energy storage and generation devices.
• THE PHAGE — The phage is a medical device company that focuses on developing AI technology to predict postprandial blood glucose levels.
• Mira Robotics — Mira Robotics is a software based company provide services that can robots in various fields.

Portfolio highlights

• Spaceflux — As satellites become increasingly vital, Spaceflux tackles the growing challenges of orbital congestion and debris that put them at risk. Thanks to our proprietary global network of optical sensors, we provide data-driven space situational awareness services from LEO to Cislunar.
• Alloyed — Alloyed delivers cutting-edge innovation in materials science, additive manufacturing, and advanced metallurgy. Explore our technologies and career opportunities.
• UnaBiz — Based in Singapore, Taiwan and Japan, UnaBiz delivers end-to-end customised IoT solutions worldwide. Simple, cost-efficient & low maintenance

Portfolio highlights

• NovAccel — NovAccel operates as a deep tech company, ensure a stable supply of medical radioisotopes.
• AstroX — AstroX is a private space startup company that develops satellite launch vehicles for space development. It utilizes the rockoon method for developing launch vehicles and small rockets to help clients easily use space.
• Sonire Therapeutics — SONIRE Therapeutics Inc. (SONIRE) is working on a next-generation high-intensity focused ultrasound (HIFU) therapy system that will employ acoustic engineering (ultrasound) technologies developed through cutting-edge academic research. SONIRE has been working on a next-generation high-intensity focused ultrasound (HIFU) treatment system as a noveltherapeutic modality with the goal of giving cancer patients and their families a new future.

Portfolio highlights

• BitBiome — BitBiome is a microbiome analysis company that aims to discover and understand disease-linked microorganisms. Its, single-cell whole-genome analysis platform specifically targets microbes and can be used on uncultured, raw samples, providing unprecedented strain-level quantitative and functional insights.THe company was founded in 2018 and isbased in Japan.
• TopoLogic — TopoLogic designs and manufactures heat flow sensors, thermoelectric conversion devices, and topological and novel spintronics materials.
• Global Equipment Services — As a strategic partner to developers of multi-sector products, Averna provides innovative automated testing tool and quality assurance solutions.

Portfolio highlights

• JiMED — JiMED designs & develops AI based brain-computer interface for implant in ALS patients to improve communication.
• Cosomil — Cosomil develops early diagnostic drugs for diseases and provides research and development support to healthcare companies.
• Physiologas Technologies — Physiologas Technologies is a manufacturing company that designs and develops medical equipment for the healthcare industry.

Portfolio highlights

• Phamily — Full-service care transformation powered by 10+ years of experience, a dedicated clinical workforce, and our AI-enabled platform.
• BitBiome — BitBiome is a microbiome analysis company that aims to discover and understand disease-linked microorganisms. Its, single-cell whole-genome analysis platform specifically targets microbes and can be used on uncultured, raw samples, providing unprecedented strain-level quantitative and functional insights.THe company was founded in 2018 and isbased in Japan.
• PopChill — PopChill generates an online marketplace for second-hand trade, enabling users to share their fashion styles and sell idle items.

Portfolio highlights

• Nexta — Nexta manufactures site, issues such as analog management, personalization of operations & labor shortages are becoming more serious.
• OOYOO — OOYOO Co., Ltd. is a DeepTech venture that combines international entrepreneurial spirit, and a 'Made In Japan' excellence, to bring the latest innovations in clean technology to society for a smarter, cleaner, and more mobile world.
• Toregem BioPharma — Toregem BioPharma is a startup from Kyoto University that develops a treatment for congenital adentia. Toregem BioPharma is headquartered in Kyoto, Japan.

Portfolio highlights

• Agentio — Agentio's patent-pending ad platform empowers marketers to finally unlock scalable, creator-led advertising. Programmatically buy the highest quality creator and influencer ad reads to deliver unprecedented efficiency and performance.
• Codis.io — COD LEGAL BLOG CONTACT US Areas We Serve California Florida TEXAS Ohio Trusted Insights on Birth Injury and Medical Negligence Law COD LEGAL BLOG is a dedicated legal information platform created to help readers understand complex legal matters in a clear and structured way. Click here to learn more. The legal system can often feel
• Quantflo — Options market intelligence and structured trade planning for Indian markets.

Portfolio highlights

• Neubond — Neubond develops wearable devices for stroke mobility rehabilitation. These devices provide autonomous assistance and therapy during daily activities, integrating rehabilitation into the patient's daily life regardless of their motor capabilities. Neubond's solutions are designed to be intuitive and effective, aiming to improve thequality of life for individuals undergoing rehabilitation.
• Pestalozzi Technology — Pestalozzi Technology is a development and provision of educational products in the fields of physical education and club activities.
• Gel-Coat Biomaterials — Gel-Coat Biomaterials is a biotechnology company that develops innovative bio-based materials and new medical technologies.

Portfolio highlights

• Integra Therapeutics — Integra Therapeutics is a developer of next generation of gene editing tools to cure diseases.
• Accipiter Biosciences — Accipiter Biosciences is a biotechnology company.
• Harness Therapeutics — Transine Therapeutics is a private biotechnology company focused on the development of a novel class of therapeutic RNAs that can upregulate protein expression with an unprecedented level of control and specificity: the SINEUPs®. The company's pioneering technology is expected to offer an entirely unique mechanism of action for currentlyhard-to-treat diseases by massively extending the druggable proteome and allowing it to address diseases that have been beyond the reach of small molecules, conventional biologics, or gene therapies.

Portfolio highlights

• AMI — AMI Corp is engaged in medical consulting, medical device development and writing.
• Do. Sukasu — Do. Sukasu is a software company that specializes in the development of visual space perception ability for brain science approaches.
• HEAL-lll — HEAL-lll is a multifaceted firm that merges healthcare, technology, and gamification to promote individual and organizational well-being.

Portfolio highlights

• TSK Corporation —
• IKOU — IKOU is an inclusive brand for babies and children that creates products valued by all users. The company's featured products include portable seats, bibs, and children's clothing products along with online services.
• Metro Weather — Metroweather is a venture from Kyoto University that develops a high-performance Doppler lidar that measures the direction and speed of wind several tens of kilometers away from minute movements of fine particles in the atmosphere. We aim to contribute to the safety of the sky by completing a three-dimensional wind map, which has never beenrealized,based on years of research at the Kyoto University Research Institute for Sustainable Areas.

Portfolio highlights

• Molmir — Molmir is a biotech company that conducts research and develops treatments for intractable diseases based on sensing technology.
• EUV Photon — EUV Photon is an irradiation services company that conducts processing, evaluation, and measurement of materials for EUV lights.
• Restore Vision — Restore Vision is a startup based in Japan aiming to develop a visual restoration gene therapy.

Portfolio highlights

• Junten Bio — JUNTEN BIO is a company is to develop new technologies in the field of regenerative medicine.
• Chromocenter — Chromocenter is a next generation biopharmaceuticals Manufacturing company. It uses technologies such as artificial chromosome vectors, mainly for drug discovery such as medical pharmaceuticals
• Noile-Immune Biotech — Neurymune Biotech Co., Ltd. is a national cancer research center specializing in the development of cancer immunotherapies based on CAR-T cell therapy and a venture company from Yamaguchi University. They aim to be a leading company responsible for the next generation in the field of cancer immunotherapy.

Portfolio highlights

• LIGHTz — LIGHTz delivers a technology transfer and information exchange platform leveraging AI.
• Celaid Therapeutics — Celaid Therapeutics specializes in manufacturing and sales of regenerative medicine products utilizing human hematopoietic stem cells.
• Veneno Technologies — Veneno Technologies engages in the research and development of therapeutic disulfide-rich peptides and contribute to advanced medicine.

Portfolio highlights

• GoodData.AI — GoodData is a leading composable data and analytics platform. Build, embed, and scale analytics on demand, with zero vendor lock-in.
• Fuse Universal — Fuse is the learning platform that allows your people to connect with the knowledge and expertise they need to improve their skills and perform.
• Lighthouse — Lighthouse transforms complexity into confidence with actionable insights, business intelligence & pricing solutions that maximize revenue.

Portfolio highlights

• Eco-Pork — Eco-Pork is a co-creation solution farm that supports farmers' food productivity improvement. It is connecting the pig and technology, pork ( Pork ) new business ecosystems ( Ecosystem By building a), in the pork growing demand around the world, to get the most out of the food supply capacity is finite.
• Equmenopolis — Equmenopolis is an information services company that specializes in conversational AI agent platforms and application developments.
• Surv Biopharma — Surv Biopharma develops a drug discovery platform that facilitates research and development of veterinary drugs and pharmaceutical products.

Portfolio highlights

• Flosfia — FLOSFIA is a spin-off from a research of Kyoto University, specializing in film-formation by mist chemical vapor deposition (CVD). Making use of physical properties of gallium oxide (Ga2O3), FLOSFIA has devoted to development of low-loss power devices.
• Hacobell — Hacobell is a logistics company that offers services in freight servicing, dispatch, and delivery.
• Power Wave — Power Wave seeks a carbon-neutral world using wave technology for wireless power, tackling global warming and fuel depletion.

Portfolio highlights

• KG Motors — KG Motors is an automotive firm that manufactures electric vehicles that can be moved comfortably and safely by one person.
• xCARE — xCARE specializes in the development and commercialization phases of the pharmaceutical and medical device industries.
• Pixie Dust Technologies — Pixie Dust Technologies is a developer of computational technologies, including its ultrasonic phased array system with which one can generate force in mid-air; transport things in mid-air without touching anything; target and deliver different sounds from person to person in a crowd; direct guide-dogs; and even apply this in agricultural farming.

Portfolio highlights

• Mobcast group — mobcast is a sports entertainment company that operates a mobile entertainment platform for smartphones and feature phones. It supports customers with social game and social media services. The company was founded in 2009 and is based in Tokyo, Japan. Currently, it operates as a subsidiary of mobcast Inc.
• SmartApp Japan — Smart Apps is a developer of a blockchain services application designed for smartphones. The company's application uses cryptocurrency technology to offer token issuance, initial coin offering and dApps design support, providing a launchpad for start-up blockchain-related businesses.