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Top 50 Health Care Startup Investors in Israel in February 2025

Last updated: Feb 2025 A list of 50 angel investors and VC (Venture Capital) funds that invest in Health care startups based in Israel. We rank investors based on the number of investments they made in Health care companies from Israel. We update this investor list every month.

Top 50 Health Care Startup Investors in Israel in February 2025

Investor	Health Care Israel investments
Pontifax	23
OurCrowd	18
Trendlines Group	15
Israel Innovation Authority	14
Accelmed	10
Triventures	9
OrbiMed	9
Vertex Ventures Israel	8
Firstime Venture Capital	8
Kli Capital	7
aMoon Fund	7
Docor International Management	7
Pitango VC	7
Elron Ventures	6
HBL Hadasit Bio Holdings	6
fresh.fund	6
Sarona Ventures	6
Sapir Venture Partners	6
SeedIL Ventures	6
TAU Ventures	5
J-Ventures	5
Integra Holdings	5
Entrée Capital	5
ALIVE Israel HealthTech Fund	5
Johnson & Johnson Robotics and Digital Solutions	5
Clal Biotechnology Industries	5
Agriline	5
Marius Nacht	5
Grove Ventures	5
Arkin Holdings	5
Terra Venture Partners	4
Btomorrow Ventures	4
NextLeap Ventures	4
XTX Ventures	4
Hanaco Venture Capital	4
The Chartered Group	4
New York Ventures	4
Tal Ventures	4
LionBird	4
Takeda Ventures	4
Good Seed Ventures	4
Connecticut Innovations	4
Lightspeed Venture Partners	4
TechWald Holding S.p.A.	3
Chartered Opus	3
PipelBiz.com	3
Aster	3
Israel Biotech Fund	3
Sanara Ventures	3
Ziegler Meditech Equity Partners	3

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Pontifax is a healthcare-dedicated venture capital firm.The fund focuses on innovative bio-pharma opportunities.

Investment focus

Biotechnology, Health Care, Therapeutics
Series A, Series B, Series C
United States, Israel, France

Portfolio highlights

ADCendo — ADCendo ApS is a biotech company dedicated to developing new types of anti-cancer drugs. We focus on antibody-drug conjugates (ADCs) directed at novel targets, that have been found to be overexpressed by several cancer forms, that are all characterized by a significant unmet need for novel treatment.
Adcytherix — Adcytherix is a biopharmaceutical company focused on the development of novel antibody drug conjugates (ADC) to treat high unmet need diseases such as cancer.
Indapta Therapeutics — Indapta Therapeutics is a privately held biotechnology company developing an NK (natural killer) cell therapy platform for the treatment of blood and solid tumor cancers.

Access exclusive venture capital angel investment deals in pre-vetted startup companies. Create your free OurCrowd investor account today!

Investment focus

Software, Artificial Intelligence, Machine Learning
Series B, Series A, Seed
Israel, United States, New Zealand

Portfolio highlights

Lidwave — Lidwave’s deep-tech solution revolutionizes 3D sensing and the verticals relying on it by examining the biggest challenge in LiDAR technology from a new perspective, free of bandwidth limitations.
Kando — Kando is an end-to-end solution that creates continuous awareness of events in the collection system. Kando enables utilities to remotely and continuously improve their operations by providing the following features:• Realtime wastewater quality data across the collection system • Pinpoint sources of pollution • Early warnings of damaging WWTPinfluent quality • Machine learning that evolves with your network • Autonomous sampling units • User fee calculator • Customized pollution alerts • A user-friendly, online interface • Detection of COVID-19 infection rates (New)The combination of these actionable insights results in:• Reduced CAPEX/OPEX • Greater WW reuse capabilities • Improved public health • Cleaner environmentsKando has been deployed in Los Angeles, Milan, Brisbane, and many other cities. To gain a greater understanding of how our system can help your organization, visit our homepage at www.kando.eco.
Blue Tree Technologies Ltd. — Blue Tree’s mission is to develop a sugar reduction platform for industrial applications in the drinks industry.

Trendlines Group invents, discovers, invests in, and incubates innovation-based medical and agrifood technologies. Trendlines invests principally through medical and agrifood incubators in Israel and in Singapore, its in-house innovation center, Trendlines Labs, and its Funds - the Trendlines Agrifood Fund and the Bayer Trendlines Ag InnovationFund.The company was founded in 1993 and is headquartered in Misgav, Israel.

Investment focus

Biotechnology, Health Care, Medical Device
Seed, Funding Round, Series A
Israel, Singapore, United Kingdom

Portfolio highlights

AgriG8 — AgriG8 is an enterprise designed to align, collaborate, de-risk and grow value chains and ecosystems within the agricultural industry.
Peptobiotics — We make agriculture more productive, humane and sustainable by promoting growth and protecting against pathogens using a new new type of antibiotic alternative that does not cause resistance. Our recombinant peptides are synthetic biology products manufactured in a patent pending precision fermentation process. We are launching a range of products across livestock and aquaculture in Asia.
Arcuro Medical — Arcuro develops a new repair system for meniscus tears of the knee. Arcuro’s proprietary SuperBall repair system consists of a knotless, all-suture anchor and innovative delivery system. The company was founded in 2013.

The Israel Innovation Agency, the Innovation Authority, was established in 1965 as the Office of the Chief Scientist of the Ministry of Industry and Trade and was designed as a body that supports R & D conducted in the framework of government research institutes. Industrial development in order to increase industrial exports of high-techproducts. The Chief Scientist focused on reducing the risk by participating in financing the project, which the private companies chose and led.

Investment focus

Health Care, Medical Device, Biotechnology
Grant, Seed, Pre-Seed
Israel, United States, Mali

Portfolio highlights

Lidwave — Lidwave’s deep-tech solution revolutionizes 3D sensing and the verticals relying on it by examining the biggest challenge in LiDAR technology from a new perspective, free of bandwidth limitations.
i-EcoGuard — I-Ecoguard is pioneering sustainable agriculture with cutting-edge nanoparticle technology. Our objective is to improve greenhouse efficiency, plant health, and crop quality.
Eretz Angels — Eretz Angels supports technology startups in Israel's outskirts at the start of their journey.

Accelmed is a venture capital firm that funds private and public medical device companies with significant market potential and proven clinical data.Concentrating on medical device companies that have already reached the revenue stage enables the firm to assist companies in benefiting from its managerial capabilities and financial resources.Together with the management teams of their portfolio companies, the Accelmed can steer the way from the clinical-stage to a profitable business with a clear commercial plan, thereby accelerating the path to a successful exit.In 2009, Mori Arkin and Uri Geiger, the co-founders of Accelmed, established the firm in Herzliya, Tel Aviv.

Investment focus

Health Care, Medical Device, Medical
Funding Round, Series A, Series D
Israel, United States

Portfolio highlights

Revamp Medical — Revamp medical was founded in 2016 with the goal of resolving one of the most urgent unmet needs in Acute Heart Failure patients. Targeting a market of >1M annual admissions in the US with a direct cost of $65B, Revamp is set to deliver an easily adoptable solution using its patented temporary catheter, Doraya™.Revamp has a seasoned team ofprofessionals with a proven track record in leading multiple med-tech startups.
Minerva Surgical — Minerva Surgical develops minimally invasive devices to treat the root causes of Abnormal Uterine Bleeding.
Click Therapeutics — Click Therapeutics develops and commercializes software as medical treatments for people with unmet medical needs. Through cognitive and neurobehavioral mechanisms, Click’s Digital Therapeutics™ enable change within individuals, and are designed to be used independently or in conjunction with biomedical treatments. The Clickometrics® adaptive datascience platform continuously personalizes user experience to optimize engagement and outcomes. Following a groundbreaking clinical trial, Click’s industry-leading smoking cessation program is available nationwide through a wide variety of payers, providers, and employers. Click’s lead prescription program is entering into a multi-center, randomized, controlled, parallel-group, phase III FDA registration trial for the treatment of Major Depressive Disorder in adults.

Triventures is a global, early stage fund that invests in exceptional entrepreneurs. We partner with disruptive ventures with innovative breakthroughs in healthcare and beyond. Our vision is to create a better, healthier future through data driven solutions and cross industry convergence.

Investment focus

Health Care, Medical Device, Medical
Funding Round, Series A, Series B
United States, Israel, Ireland

Portfolio highlights

Grin — Grin is a comprehensive digital orthodontic platform providing teeth straightening for all types of patients with a real local orthodontist. The platform also connects patients with a real orthodontist from the convenience of their smart device. They deliver responsible care from orthodontic specialists in an easily accessible and cost-effectiveway, Grin provides patients quality care that results in an exceptional smile together with all of the modernized convenience that they expect.Grin technology, aligned with a network of local trusted orthodontists, ensures that every patient gets the right care. The platform Grin App and Grin Scope is a patent-pending technology that offers remote monitoring for a variety of orthodontic needs. The Grin experience includes high-quality self-scans with the latest teeth straightening solutions. Practitioners and patients can now use these telemedicine tools to achieve a new, more convenient treatment journey.It was founded by Dr. Adam Schulhof, Pamela Oren-Artzi, and Alon Lipnik in 2019 and is based in New York and Austin.
Cala Health — Cala Health is a bioelectronic medicine company transforming the standard of care for chronic disease. The company's wearable neuromodulation therapies merge innovations in neuroscience and technology to deliver individualized peripheral nerve stimulation. The first indication for Cala Health's wearable therapy is an essential tremor, adisease experienced by more than seven million people and characterized by severe hand tremors. New therapies are under development in neurology, cardiology, and psychiatry. The company is headquartered in the San Francisco Bay Area and backed by leading investors in both healthcare and technology.
TailorMed — Moving Mountains for Patients

Leading Global Healthcare Platform with Deep Proprietary Resources and Global Industry Coverage.

Investment focus

Biotechnology, Health Care, Medical
Series B, Series A, Series C
United States, China, Israel

Portfolio highlights

Aerin Medical — Aerin Medical offers VivAer for nasal airway obstruction treatment and RhinAer for chronic runny nose treatment. Lasting relief when other solutions fall short.
Stairway Medical — Stairway Medical is a developer of implantable brain-computer interface technology.
Helicore Biopharma — Helicore Biopharma is at the forefront of developing cutting-edge treatments for obesity and related disorders.

We partner early with global-minded entrepreneurs seeking to disrupt large markets

Investment focus

Software, Information Technology, Artificial Intelligence
Series B, Series A, Series C
Israel, United States, Canada

Portfolio highlights

Nagish — Nagish captions your phone calls and empowers you to talk using text or voice. It's fast, private, and free.
FireDome — FireDome's innovative wildfire defense system utilizes a two-tiered approach. First, a mechanical launcher rapidly deploys a protective barrier to block the direct path of encroaching wildfires. Second, the system actively and swiftly detects and extinguishes spot fires caused by airborne embers tha
Seal Security — Streamline your open source vulnerability remediation without introducing the risk of breaking changes. Say goodbye to alert fatigue and start patching with Seal Security.

Firstime Ventures is investing in companies who are building a sustainable & accessible future for all.

Investment focus

Software, Machine Learning, Artificial Intelligence
Seed, Series A, Series B
Israel, United States, United Kingdom

Portfolio highlights

Baibys — Baibys is a medical automated platform that provides AI and robotics-based autonomous sperm selection solutions for IVF.
Pixellot — Pixellot is a leading sport media company that offers automatic production solutions for the amateur and semi-professional market. Pixellot’s patented technology streamlines the production workflow by deploying an unmanned multi-camera system that covers the entire field. Advanced algorithms enable dynamic coverage of the flow of play and highlightgeneration. The company streams more than 11,000 live video hours each month to fans, players, and coaches on a variety of platforms. Founded in 2013 by seasoned video and media technology experts, Pixellot has sold over 2,000 systems around the world, deployed with minor leagues, high schools, as well as at youth academies and top league clubs. Pixellot’s partners include ESPN, PlayOn Sports, the US’ biggest high school sports media company and right holder, Sporttotal.tv, Germany’s largest amateur league media platform, global coaching solution provider STATS, SeeUPlay in Mexico and Hockey TV, North America’s largest non-NHL ice hockey streaming platform. The company also works directly with leading clubs such as Bayern Munich, Spain’s Real Sociedad, Dutch AZ Alkmaar and Maccabi Tel-Aviv.
Securithings — Bringing IT Standards to the IoT Space.

Kli Capital is a firm focused on investing in fearless entrepreneurs who are building foundational enterprise technologies and ubiquitous consumer brands. We partner with exceptional founders with unique insights, from inception through all phases of growth.

Investment focus

Health Care, Software, Wellness
Seed, Funding Round, Series A
United States, Israel, Mexico

Portfolio highlights

LexCheck — Transform your contract negotiation process with AI. Review, redline and approve contracts quickly and economically with the power of automation.
VersusGame — VersusGame offers creators and brands the opportunity to cultivate a community with an interactive content solution that rewards knowledge
Cooper — Your parenting lifeline.

aMoon is a leading healthtech & life sciences venture capital firm.

Investment focus

Health Care, Biotechnology, Medical
Series B, Series A, Funding Round
United States, Israel, Switzerland

Portfolio highlights

Lyfegen — Lyfegen is the first of its kind, a company making value-based healthcare contracting for high-cost therapies a reality for all healthcare stakeholders.
PrognomiQ — PrognomiQ is invested in transforming the detection and early treatment of cancer and other complex diseases. Learn more about our test products and careers.
MetaSight Diagnostics — MetaSight Diagnostics, a health technology company, is on a mission to develop affordable and precise liquid biopsy diagnostics for the early detection of a wide range of chronic and acute diseases by leveraging proprietary mass spectrometry technologies (metabolomics, lipidomics, and proteomics).

Docor International B.V. is a fully-owned subsidiary of Crecor B.V. Both Docor and Crecor were formed as wholly-owned subsidiaries of the Van Leer Group Foundation to promote and participate in commercial activities in Israel.

Investment focus

Health Care, Biotechnology, Pharmaceutical
Funding Round, Series C, Series A
Israel, United States

Portfolio highlights

Check-Cap — The first and only patient-friendly preparation-free test to detect polyps before they may transform into cancer
Ocon Healthcare — OCON Healthcare innovates, develops, manufactures, and commercializes cutting-edge women’s health products based on our patented IUB™ (Intra Uterine Ball) proprietary platform. The IUB™, made from a super-elastic alloy Nitinol, is an ideal carrier for multiple drugs to the uterus to treat a variety of conditions.In addition to our flagshipproduct, the IUB™ Ballerine®, OCON healthcare is developing an innovative pipeline of products utilizing the IUB™ frame for indications such as abnormal uterine bleeding (AUB), heavy menstrual bleeding (HMS), myomas/fibroids, and infertility.
Raziel Health — Raziel Health’s mission is to bring world-class, disruptively less expensive healthcare to everyone, in the comfort of their home. Its unique, integrated system combines easy-to-use technologies that support positive patient experience, enable timely clinical intervention, and meet individual patient goals while using data analytics to supportwellness and disease management.

Pitango VC is a venture capital firm focused on health-tech (Pitango Health-tech) and growth (Pitango Growth) investments in startups around the world in domains such as vertical SaaS, digital health, deep tech, fintech and insurance technology, devops, generative AI, Web3, and food tech.With two offices in Israel, Pitango currently managesseveral venture funds totaling over $2.8 billion in committed capital. It has invested in more than 250 companies.

Investment focus

Software, Health Care, Information Technology
Series A, Series B, Series C
Israel, United States, China

Portfolio highlights

Homethrive — Homethrive is dedicated to helping families care for their loved ones who are aging or have special needs. Discover how our caregiving solution, Dari, can help you!
Guardoc Health — Streamlining clinical compliance with AI-driven accuracy in charting to meet regulations, enhance patient care, and optimize revenue management.
Quantum Source — Quantum Source is on a clear path to the most powerful, cost-effective, practical photonic quantum computer. Learn more.

Elron Ventures is an early-stage investor committed to turning promising ideas into global industry leaders, with a proven track record of investments and successful M&As worldwide. Elron invests in cyber security and B2B software. Since its establishment in 1962, Elron stands on the forefront of Israeli innovation both as a founder and earlyinvestor in companies across various industries such as Elbit, Medingo, Given Imaging, Cloudyn, Cyber Secdo, and Alcide.

Investment focus

Information Technology, Health Care, Software
Seed, Series A, Funding Round
Israel, United States, China

Portfolio highlights

Creednz — Creednz is a company that provides financial data management system that involves internal financial data sets.
Entitle — Control access to your organizational cloud resources without creating bottlenecks or friction while creating a seamless experience for employees.
Tamnoon — Tamnoon develops a state-of-the-art cloud security platform to empower security teams and manage cloud risks effectively. By harnessing the power of AI combined with human expertise, the company empowers security teams and equips organizations of all sizes with exceptional cloud protection capabilities.

Hadasit Bio-Holdings Ltd. ("HBL") was founded and floated on the Tel Aviv Stock Exchange (TASE : HDST ) and recently on the OTC (OTCBB : HADSY ) in order to allow public participation in the highly promising field of biotechnology.It serves as a precedent in biotech financing - for the first time, public investment is allowed toparticipate in a holding entity including companies based on IP generated by Israel’s foremost medical research center – Hadassah University Hospital ("HU").In addition to the public holdings (54%) – including major Israeli institutional investors, HBL is held by Hadasit (www.hadasit.co.il) (36%) and Consensus Business Group (http://www.consensusbusiness.com) (10%). The traded stock, as a unique investment vehicle, provides investment exposure to a select cluster of 6 biotech companies - all based on inventions developed and owned by HU.HBL is a publicly traded subsidiary of Hadasit Ltd. – the technology transfer company of the Hadassah University Hospital in Jerusalem, Israel. Hadasit was established for the purpose of promoting and commercializing the intellectual property (IP) and R&D capabilities generated by Hadassah, aimed at finding solutions to problems faced by modern medicine.

Investment focus

Biotechnology, Medical, Health Care
Funding Round, Series A, Series B
Israel

Portfolio highlights

ProtAb — ProtAb develops therapeutic agents that modulate cytokine regulation, tipping the balance toward anti-inflammatory signaling pathways in the treatment of autoimmune and inflammatory diseases. Its first product, Prozumab, is a monoclonal antibody with a novel mechanism of action. It is currently in late-stage preclinical development for thetreatment of inflammatory bowel disease or IBD, ulcerative colitis or UC, and rheumatoid arthritis or RA. It operates as a subsidiary of Hadasit Bio-Holdings. HBL is a publicly traded subsidiary of Hadasit, the technology transfer company of the Hadassah University Hospital in Jerusalem in Israel.
KAHR medical — KAHR Medical ("KAHR") is pioneering the development of "third generation biological drugs," a unique class of proprietary fusion-protein molecules with clear and far-reaching advantages. KAHR's technology represents a paradigm shift in protein-based pharmaceuticals that will significantly expand available treatment optionsfor cancer and autoimmune disorders.
Enlivex Therapeutics — Enlivex is a clinical-stage macrophage reprogramming immunotherapy company that targets diseased macrophages in patients with sepsis. The company develops an autologous and allogeneic drug pipeline for the treatment of autoimmune and inflammatory conditions such as Graft versus Host Disease (GvHD), solid organ transplant rejection, Crohn'sDisease, and other autoimmune and inflammatory disorders.The company's revolutionary approach is to induce immune tolerance by injecting apoptotic cells and facilitating their interaction with dendritic cells activates the body's innate, physiologic mechanism for down-regulating inflammation and autoimmunity.Enlivex is an Israeli-based cell immunotherapy company established in October 2005 by Professor Dror Mevorach, a world-renowned expert on clearance of dying (apoptotic) cells.

fresh.fund is an Israeli pre-seed venture capital fund investing in early-stage startups across segments and verticals.We're built to partner with early-stage founders from day one, often as the company's first institutional investors. Our model is refreshingly simple: up to $300,000 in pre-seed funding within <4 weeks and follow-oncapital as necessary.Check out our portfolio here >> https://www.fresh.fund/portfolio. It's never too early to have a conversation about your startup.

Investment focus

Health Care, FinTech, Education
Seed, Pre-Seed, Series A
Israel, United States, Norway

Portfolio highlights

enso — enso offers AI-powered bot bundles to automate your marketing strategy. Perfect for small business owners, our bots handle social media, SEO, lead generation & much more. Start with a 7 days free trial or talk with one of our marketing experts today.
Carbon Blue — Carbon Blue is developing an 'ocean-capture' scalable method for removing CO2 from the atmosphere. The company was founded by Iddo Tsur and Dan Deviri.
Guardoc Health — Streamlining clinical compliance with AI-driven accuracy in charting to meet regulations, enhance patient care, and optimize revenue management.

Founded in 2019, Sarona Ventures is a venture capital firm based in Tel Aviv, Israel. The firm is a "people-first" investor, seeking founding teams with strong execution capabilities. The firm's investment scope focuses on enterprise software, and most of their deals concentrate on building the future of business with AI, helpingcompanies operate more efficiently, save money, and drive revenue.

Investment focus

Software, Information Technology, Machine Learning
Seed, Pre-Seed, Series A
Israel, United States, United Kingdom

Portfolio highlights

Visitt.io — Come to Visitt and see why CRE & multifamily property management, tenant experience and building operation teams all love our easy to use tools & tenant apps
Yuzu Health — Powering innovative health plans
Crowded — Banking for Greek Life that allows you to seamlessly pay dues, P2P transfers, deposits, and make payments with your virtual debit card. Tailored tools for events, ticketing, chat organizational management and more.

Early Stage VC

Investment focus

Software, Biotechnology, Machine Learning
Seed, Pre-Seed, Series A
Israel, United States, United Kingdom

Portfolio highlights

Enzymit — Enzymit's platform technology can build molecular machines that enable never before seen chemistry aiming to solve humanity's greatest challenges
Lidwave — Lidwave’s deep-tech solution revolutionizes 3D sensing and the verticals relying on it by examining the biggest challenge in LiDAR technology from a new perspective, free of bandwidth limitations.
DeepCure — DeepCure is a Boston-based therapeutics company that harnesses advanced AI, physics-based tools and automation to discover novel small molecules for challenging targets. DeepCure currently has a lead asset in IND-enabling studies and other programs focused on drugging intractable targets that have t

SeedIL Ventures is a seed stage investment fund focusing on Israeli related companies in any sector except medtech/biotech and heavy Hardware. After investment, SeedIL is committed to ensuring that portfolio companies reach their full potential by providing on-going coaching and connections through its extensive network, including the Limitedpartner's connections and intelligence.

Investment focus

Artificial Intelligence, Software, Big Data
Seed, Series A, Pre-Seed
Israel, United Kingdom, Australia

Portfolio highlights

Wisor — Propelling the supply chain industry into the digital age Wisor is a plug & play solution that provides a global automated quoting solution that allows freight forwarders to generate quotes and communicate with clients automatically Get a demo What took days now takes minutes Wisor is specifically designed to support and simplify the complexity of generating quotes
BlinqIO — BlinqIO developed an autonomous AI-operated virtual tester (BVT) - the BVT receives as input test scenarios, takes decisions how to perform the tests and creates in the background test automation code.
Treetoscope — The first and only commercial device that senses the internal water flow of a plant and directly measures its water consumption and real-time irrigation needs. without extrapolations based on indirect sensing technologies.Treetoscope offers a SaaS irrigation management platform, based on direct plant sensing technology. We tackle one of the mostcrucial challenges farmers face today: water scarcity and irrigation optimization. Our groundbreaking ag-tech enables the unprecedented measurement of real-time actual water use of trees (based on our patented single probe Sap Flow sensor). Through the Treetoscope solution, growers gain great value as a result of the affordability, scalability, and ease of deployment of our technology.

TAU Ventures is an early-stage focused venture capital fund affiliated with Tel Aviv University, investing in the next generation of impactful home-grown technology companies. At the heart of the start-up nation, TAU Ventures invests the first capital into startups and is dedicated to helping them transform their ideas into global businesses.TAU Ventures cultivates an innovation ecosystem by combining the resources and global network of Tel Aviv University, strong industry connections, and a supportive home-base for founders. Together with its world-leading team of experienced mentors, TAU Ventures empowers startups in their critical, early steps. At its 1000 sq meter co-working office space located in Tel Aviv, the team works shoulder to shoulder with their portfolio companies, nurturing their growth by drawing on the strength of its innovation ecosystem on a daily basis.

Investment focus

Software, Artificial Intelligence, Information Technology
Seed, Pre-Seed, Series A
Israel, United States

Portfolio highlights

Cerby — Collaborate without chaos. Cerby helps your team be productive while protecting your brand. Secure unmanageable applications. Only with Cerby.
Momentick — Momentick's advanced algorithms unlock the power of satellite imagery to measure, monitor and reduce GHG emissions. Our on-demand emissions intelligence delivers the technology industries and regulatory bodies need to autonomously detect & monitor emissions on a global scale.
Kerna Labs — Developing better genetic medicines, built with AI.

J- Ventures is a Silicon Valley based group of VC funds with over $60m under management. Backed by 400+ leading Investors ( 140+ Serial founders, 100+ VCs, 170+ Fortune 500 Executives) as LPs. Our active-LP venture fund brings the power of this connected & intellectual capital to add real value to the companies we invest in and create aremarkable difference by helping our founders grow and scale to markets quicker. Based in Silicon Valley with investors from 15 communities - Tel Aviv, NYC, LA, London, Miami, Boston, and more. Since 2016 the group made over 50 investments, 4 unicorns and over 10 exits.

Investment focus

Software, Health Care, Machine Learning
Series A, Seed, Pre-Seed
United States, Israel

Portfolio highlights

Kardome — Kardome offers a real-time software suite that can be inserted in a variety of processing environments. The company engages a real-time software beamformer to improve speech signals from several speakers. It offers high-quality sound output without the need to shout or position the users mouths close to the microphone. The company developssolutions such as voice controlled devices, hands-free speakerphones, tablets and cellphones, and conference call devices.Kardome was founded on 2018 and is headquartered in Mazor, Hamerkaz, Israel.
Monogoto — IoT Connectivity Management Platform: Monogoto Provides Global Cellular Connectivity & Private LTE Solutions As a Service. Click to Learn More
Epic Cleantec — Epic Cleantec provides sustainable onsite wastewater reuse solutions for the built environment

Our expert team is the first to examine and evaluate the Hebrew University's biomedical breakthroughs. We then capitalize decades of experience - transforming the inventions into pioneering companies. Our golden eggs Ayana Pharma A late stage company with

Investment focus

Biotechnology, Pharmaceutical, Life Science
Seed, Series B, Series F
Israel

Portfolio highlights

BacoCure — BacoCure is developing a novel bacterial product for local therapy of non-muscle invasive bladder cancer (NMIBC) patients.
Splisense — Splisense is develops antisense oligonucleotide based therapies to target genetic diseases caused by splicing mutations. The company has developed a compound to cure the lung disease in cystic fibrosis patients carrying a specific splicing mutation. It is also developing a targeted modulation approach to correct the splicing pattern of CFTRtranscripts according to the specific mutation carried.
Rebiotic Rx — Develops nanotechnology-based antibiotics with the focus on resistant bacteria

We're a team of former serial founders managing over $1.25B across a number of funds, with offices in Tel Aviv, London, and New York.

Investment focus

Software, FinTech, Financial Services
Seed, Series A, Series B
Israel, United States, United Kingdom

Portfolio highlights

Obligo — Rid yourself from the burden of security deposits and go deposit-free. Landlords paid instantly on claims, while tenants repay in installments.
PointFive — PointFive provides ongoing cloud cost savings by providing deeper detection and collaborative repair solutions that fit smoothly into teams' normal operations.
Archy — SaaS Practice Management Software for Dental Practices

ALIVE Israel HealthTech Fund is a pioneer mid-to-late stage HealthTech fund leveraging an exclusive ecosystem.

Investment focus

Health Care, Medical, Biotechnology
Series A, Funding Round, Series B
Israel, United States

Portfolio highlights

Vessi Medical — Vessi Medical is developing an innovative, IP protected cryo spray for hollow & humid organs, a new approach in the treatment of Non Muscle Invasive Bladder Cancer (NMIBC).
Append Medical — A novel transcatheter LAA elimination system
Gina Life — At Nevia bio, we are focused on women's health. Our mission is to use innovative technologies to provide early detection of diseases through vaginal secretions analysis, enabled by Nevia's Machine Learning Platform.

Healthcare innovation wherever it originates.

Investment focus

Biotechnology, Health Care, Medical
Series A, Series B, Series C
United States, Israel, United Kingdom

Portfolio highlights

Moon Surgical — Create the OR of the future, one that is sustainable, efficient, and digitalized.
Artera — Discover the power of Personalized Precision Medicine & AI Cancer Therapy with Artera. Transforming cancer therapy through innovation.
ONL Therapeutics — ONL Therapeutics develops innovative therapeutics to protect and improve the vision of patients with a range of retinal diseases and conditions.

Clal Biotechnology Industries is a leading Israeli life sciences investment company traded on the Tel Aviv Stock Exchange (TASE: CBI).

Investment focus

Biotechnology, Health Care, Medical
Series A, Funding Round, Series B
Israel, United States

Portfolio highlights

Sight Diagnostics — Combining AI and breakthrough hardware to bring lab-quality CBC results to the doctor's office.
Cadent Therapeutics — Cadent Therapeutics is a precision neuroscience company developing novel medicines that tune and modulate brain rhythms to restore cognitive and motor function in patients with serious neurological disease. The company leverages its precision neuroscience approach combining target specificity, patient selection, drug design and optimization, andnovel quantitative endpoints to create first-in-class molecules to treat movement and cognitive disorders.It was founded in 2010 and headquartered in Cambridge, Massachusetts.
Elicio Therapeutics — Elicio ground-breaking Amphiphile technology is engineering potent vaccines and immunotherapies to defeat an array of aggressive cancers.

Agriline is the investment vehicle owned by a trust of which Trendlines' controlling shareholder Vincent Tchenguiz.

Investment focus

Health Care, Medical Device, Medical
Seed, Funding Round, Series A
Israel

Portfolio highlights

Phytolon — Phytolon revolutionizes the way food colors are produce, by Leveraging a novel and sustainable technology for production of healthy food colors in high quality at low costs. Phytolon's mission is to exploit scientific advancement promote human health and environmental sustainability
Vessi Medical — Vessi Medical is developing an innovative, IP protected cryo spray for hollow & humid organs, a new approach in the treatment of Non Muscle Invasive Bladder Cancer (NMIBC).
SetBone Medical — SetBone Medical develops a new bone cement for the treatment of VCF and primarily caused by osteoporosis.

Marius Nacht, one of Check Point’s founders, has served as Chairman of our board of directors since 2015. Nacht has also served as one of our directors since we were incorporated in 1993. From 1999 through 2005, Nacht held Senior Vice President roles at Check Point. Nacht earned a B.S. (cum laude) in Physics and Mathematics from the HebrewUniversity of Jerusalem in 1983, and an M.S. in Electrical Engineering and Communication Systems from Tel Aviv University in 1987.

Investment focus

Artificial Intelligence, Machine Learning, Health Care
Series A, Funding Round, Seed
Israel, United States, Germany

Portfolio highlights

CPTx — At CPTx, we develop new treatment paradigms across outsized medical challenges, with an initial focus on infectious diseases. The flexibility and precision of CPTx's platform supports multivalent drug development, which is crucial for addressing complex disease states involving multiple binding sites, such as viruses, cancer, and autoimmune diseases.
Wisdo Health — Wisdo is an AI-powered Social Health platform harnessing the power of data and meaningful connections to improve health.
WaveBL — WAVE BL lets you digitally issue, transfer, sign, endorse and surrender trade documents while cutting costs and eliminating fraud.

Grove Ventures is a leading early-stage venture capital fund in Israel. It partners early with exceptional Israeli founders who believe th...

Investment focus

Artificial Intelligence, Machine Learning, Software
Seed, Series A, Series B
Israel, United States

Portfolio highlights

Enzymit — Enzymit's platform technology can build molecular machines that enable never before seen chemistry aiming to solve humanity's greatest challenges
Wing Cloud — Wing Cloud tames cloud complexity through a unified programming and operational model that works across all providers and services.
Quantum Source — Quantum Source is on a clear path to the most powerful, cost-effective, practical photonic quantum computer. Learn more.

Explore Arkin Capital: A leading multi-asset manager driving strategic investments across health, technology, equity, real estate and more

Investment focus

Biotechnology, Health Care, Therapeutics
Series A, Series B, Funding Round
Israel, United States, Switzerland

Portfolio highlights

Phytolon — Phytolon revolutionizes the way food colors are produce, by Leveraging a novel and sustainable technology for production of healthy food colors in high quality at low costs. Phytolon's mission is to exploit scientific advancement promote human health and environmental sustainability
Honeycomb — Honeycomb (fka Agilius) is the only place where you can buy a condo/apartment building master policy online in less than 3 minutes at a fraction of the cost! Instant, free, no hassle quotes, online everything and up to 40% savings. With all that we're bringing simplicity and transparency to the real estate insurance space for condoassociations (HOAs), building owners, property managers, and developers everywhere. This is what we do. This is all we do.
Nocion Therapeutics — Nocion Therapeutics is a developer of novel pharmaceuticals intended to treat the conditions arising from neurogenic inflammation. The company is developing "nocions" which are a new kind of therapy that selectively affects actively firing nociceptors, enabling patients to provide targeted, robust and sustained relief for the treatment ofserious conditions including cough, itch, pain and inflammation.

We are an early stage venture capital firm dedicated to partnering with inspiring entrepreneurs to build breakthrough companies

Investment focus

Software, Information Technology, Health Care
Seed, Series A, Series B
Israel, United States

Portfolio highlights

FieldIn — Fieldin delivers risk mitigation for high value crops, helping farmers stay competitive against shrinking prices and profits.
Arugga AI Farming — Arugga develops ground robots to treat and monitor individual plants in the greenhouse. We are proud to be the first company to commercialize a robot that successfully replicates (bumblebee) buzz pollination in tomato greenhouses.
Intuition Robotics — The AI care companion robot for older adults

Btomorrow Ventures (BTV) is the corporate venturing unit of BAT. BAT is building A Better Tomorrow by reducing the health impact of its business by transforming into a truly consumer-centric multi-category CPG company. We are dedicated to partnering with ambitious and passionate entrepreneurs to realise their vision by providing a platform toenhance innovation and accelerate growth.

Investment focus

Health Care, Wellness, Food and Beverage
Series A, Seed, Series B
United States, United Kingdom, India

Portfolio highlights

Tru — Obsessively formulated by fusing flavor with function, each of our tasty innovations perform when you need it most. From the time you wake up until the second your head hits the pillow, we elevate every moment one sip at a time.
Awake Chocolate — AWAKE Chocolate combines delicious milk chocolate.
PHILTER Labs — Philter Labs presents an innovative smoke filter for E-Cig, Vape Pen, & CBD Pen. Filters smoke from entering shared space while you still enjoy the experience.

NextLeap Ventures offers investors the opportunity to invest in early stage, Israeli high-tech startups, selected through its unique, highly vetted process.

Investment focus

Software, Machine Learning, Health Care
Seed, Series A, Funding Round
Israel, United States

Portfolio highlights

Carrar — A complete thermal management solution for electric vehicles dissipating heat faster and more efficiently than ever before. Thermal management for ev batteries.
Cybord — Electronics components' quality, reliability, and highest level of traceability by leveraging visual AI and BigData
Enzymit — Enzymit's platform technology can build molecular machines that enable never before seen chemistry aiming to solve humanity's greatest challenges

XTX Ventures is the venture capital arm of XTX Markets. XTX Markets is a leading, innovation-driven algorithmic trading firm.XTX Ventures focuses on early stage startups (Seed to Series A) applying machine learning and leverages XTX Markets’ deep expertise in ML and financial technology to help grow and enhance those businesses. We are geographyand industry agnostic.

Investment focus

Artificial Intelligence, Software, Machine Learning
Series A, Seed, Funding Round
United Kingdom, United States, Israel

Portfolio highlights

iGent — iGent AI focus on integrating advanced AI capabilities into the software development process.
Verax AI — Seeks to be the leading provider of enterprise-grade trust solutions for Generative AI, enabling companies worldwide to build or adopt any Generative AI agent with confidence
Prior Labs — Prior Labs is developing innovative foundation models that understand spreadsheets and databases.

Hanaco Ventures backs early-stage technology companies with visionary and passionate entrepreneurs. Hanaco was founded by Alon Lifshitz, Lior Prosor, and Pasha Romanovski in 2017 and is headquartered in Tel Aviv, Israel.

Investment focus

Software, Financial Services, Cyber Security
Series A, Seed, Series C
United States, Israel, United Kingdom

Portfolio highlights

Amount — Amount enables growth for financial institutions with a suite of products and services that deliver a seamless digital and mobile customer experience.
Route — Track Everything You Order in the Route App. Get shipping notifications and real-time status updates on any delivery.
ZEST Security — ZEST is the AI-powered risk resolution platform that's redefining cloud risk remediation for security and DevOps teams.

The Chartered Group is an investment platform.

Investment focus

Biopharma, Agriculture, Health Care
Funding Round, Series A, Private Equity
Israel

Portfolio highlights

Zsquare — Zsquare has developed the only scalable endoscopic platform capable of transmitting high resolution images in flexible, single-use endoscopes, through polymeric fibers of any shape or size. Zsquare’s imaging technology outperforms existing technologies by delivering higher quality visualizations through smaller diameters than those found inreusable endoscopy systems.Zsquare’s polymeric fiber enables the housing of inexpensive optics with no electronics in a single-use shell, and expensive components in a detachable, reusable imaging core. This platform feature allows the use of a single core with various interchangeable shells which offer differing capabilities for different indications, facilitating any type of endoscopy procedure at a lower costs per-use.
Pepticom Ltd. — Pepticom is a privately held AI company with headquarters in Israel committed to offering AI peptide drug discovery solutions for a better and healthier world. It is the leader in the emerging peptide drugs software solutions, AI and prediction tools that allow research centers, pharma and agriculture companies to accelerate innovative moleculesdiscovery while reducing time, costs and risks. Pepticom operates in various markets; past successful discoveries include peptide molecules related to metabolic diseases and Immuno-modulators.

New York Ventures is dedicated to encouraging innovation and fueling economic growth in communities across the State. This venture capital investment arm of Empire State Development is one of New York State's business resources and innovation investments, including the Governor's START-UP NY program, Innovation Hot Spots, the RegionalEconomic Development Councils, the Centers of Advanced Technology and Centers of Excellence networks, and the SUNY 2020 Initiative.

Investment focus

Health Care, Biotechnology, Software
Seed, Series A, Series B
United States, Canada, Israel

Portfolio highlights

ZeroMark — ZeroMark is a defense product company building technology to ensure safety and precision when using kinetic and non lethal weapons.
Cell BioEngines — Cell BioEngines, Inc., is a clinical-stage biotech company focused on curing cancer by developing ”off-the-shelf” allogenic cell therapies. The company leverages its proprietary Stem-SPACE platform technology to produce clinical grade cells at scale.
Resource Monitor — Resource Monitor is a modern water monitoring and management system. Our smart water system helps you save water and money.

TAL Ventures (TAL) is an Israel based Venture Capital group with deep ties to the Israel high-tech ecosystem.

Investment focus

Software, Artificial Intelligence, SaaS
Seed, Series A, Series B
Israel, United States, Cyprus

Portfolio highlights

BlinqIO — BlinqIO developed an autonomous AI-operated virtual tester (BVT) - the BVT receives as input test scenarios, takes decisions how to perform the tests and creates in the background test automation code.
Fairgen — Data-centric approach to debiasing machine learning models and artificial intelligence algorithms.
With (Coing) — Connect residents and foster engagement with a centralized community calendar that brings all city events into one easy-to-access platform

LionBird is a Tel Aviv- and Chicago-based venture capital firm investing in early-stage software companies operating in the healthcare, commerce, and enterprise sectors. Founded in 2012, LionBird has developed an investment strategy around early-stage startups that leverages online technology to re-imagine traditional offline business processes andmodels.

Investment focus

Health Care, Software, Artificial Intelligence
Seed, Series A, Series B
United States, Israel, India

Portfolio highlights

OneStep — OneStep offers providers the ultimate digital physical therapy solution that enables remote therapeutic monitoring and boosts clinical outcomes.
Jimini Health — Jimini’s mission is to radically improve the efficacy of mental health care across the world. Jimini has developed a novel care model that combines teletherapy sessions with personalized AI support. With Jimini, your therapy care team includes your licensed clinician and Sage, your always-available AI therapy assistant, who work together to helpyou achieve your goals.Founded in 2023 by a team of seasoned AI and biotech entrepreneurs, health tech veterans, and psychology researchers, Jimini puts science and tech first, using safe, purpose-built patient-facing technology that works exclusively under clinical oversight and high safety standards.World leaders in psychology designed Jimini’s care model to ensure that every part of the patient's journey is clinically beneficial. Jimini does not believe that LLMs should replace clinicians; rather, AI will help therapists deliver higher-quality care and focus on the most complex parts of their job. Jimini’s care model is first and foremost led by excellent clinicians.Jimini is committed to improving mental health quality and creating radically better, more modern, and clinically efficacious mental health experiences for patients.
PatientPartner — PatientPartner provides a digital health platform offering real-time patient mentorship, driving engagement and adherence for pharma, med-tech, and healthcare providers.

Takeda Ventures, Inc. (TVI) is the corporate investment arm of Takeda Pharmaceutical Company Limited (TPC). TVI was founded in 2001 and invests in current and future areas of interest for TPC. They are based alongside Takeda’s R&D sites in Cambridge, MA, and San Diego, CA. As a strategic investor, TVI aims to provide support and guidance toentrepreneurs and early-stage companies driving concepts through clinical proof of concept. They also strive to forge active, collaborative interactions that result in synergies with Takeda's considerable R&D resources. Their goal is to build a portfolio of strategic investments, with an immediate emphasis on oncology, gastroenterology, neuroscience, and rare diseases.

Investment focus

Biotechnology, Health Care, Therapeutics
Series A, Series B, Funding Round
United States, United Kingdom, Israel

Portfolio highlights

Be Biopharma — Be Bio is developing a proprietary class of engineered B cells as medicines that unleash the potential of cell therapies in applications beyond cytotoxicity.
Larkspur Biosciences — Larkspur's strategy focuses on the particular ways in which tumours hijack the immune system by developing precision immunotherapies for molecularly defined patient groups to overcome the bottlenecks that allow the tumour to subvert the immune system.
EvolveImmune Therapeutics — EvolveImmune Therapeutics transforms the discovery and development of novel immunotherapies. By leveraging its proprietary in vivo target discovery platform, EvolveImmune is building a pipeline of novel therapeutic candidates against numerous targets that are expressed on multiple immune cell types. The company’s platform will generatefirst-in-class treatments for unmet needs in oncology and autoimmune diseases.

Good Seed Ventures is a Venture Capital firm that exclusively invests in sustainable food tech.

Investment focus

Food and Beverage, Food Processing, Biotechnology
Seed, Series A, Pre-Seed
Germany, Israel, United States

Portfolio highlights

Lovely Day Foods — We harness the power of plants and cutting-edge technology to crack the egg.
Libre Foods — MEAT, BUT MAKE IT MUSHROOMS. GET READY TO TASTE THE POWER OF FUNGI
Nosh Biofoods — We create nutritional and highly functional proteins from non-GMO fungi. Our proprietary ferementation process is minimal, scalable, and sustainable.

At Connecticut Innovations, we see venture capital the way you see your business. Like no one else. We invest in innovative biotech, IT, and other industries.

Investment focus

Health Care, Biotechnology, Software
Seed, Series A, Funding Round
United States, Israel, Canada

Portfolio highlights

Normunity — We create medicines that free normal immunity to defeat cancer using proprietary platforms that uncover novel immuno-oncology mechanisms.
VeraDermics — VeraDermics Inc. is a dermatology pharmaceutical start-up, makers of WartPatch
Nimbus Power Systems — Nimbus builds a cleaner world through design and integration of zero-emission fuel cell systems for heavy-duty markets.

Lightspeed Venture Partners is a multi-stage venture capital firm focused on accelerating disruptive innovations and trends.

Investment focus

Software, Information Technology, Artificial Intelligence
Series A, Series B, Seed
United States, India, Israel

Portfolio highlights

Tana — Tana is a software development company that reinvents how humans, teams, and computers work together. Tana was founded in 2020 and was headquartered in Oslo, Norway.
Archive — We help brands launch their own secondhand resale marketplace.
Eternal — Eternal provides lifelong athletes with an expert team of health and performance advisors to keep them going in the activities they love for as long as possible.

TechWald Holding S.P.A. - TWH - Operational Holding Company supporting high growth potential early stage companies committed to develop Healthcare Innovation.We have a key strategy focus on MedTech industry and Medical Technologies - medical devices, equipment, digital devices and services -which can provide benefit and value for Patients, Doctors and Healthcare Systems,and reward Shareholders with a sound and ethical profit

Investment focus

Health Care, Medical, Medical Device
Series A, Series B, Series C
Israel, United States

Portfolio highlights

SoniVie — SoniVie's lead product, TIVUS, is an investigational intravascular treatment that can be performed as part of a routine right heart catheterization for patients suffering from pulmonary arterial hypertension (PAH)
SentiAR — SentiAR is digital health, software device company adding a new dimension to clinical practice in interventional procedures. Spun out of Washington University, we are developing the first 3D visualization platform using real-time holography of the patient's anatomy and catheter location, "floating" over the patients, with a goal toprovide the clinician and patient a faster, safer delivery of care.SentiAR’s mission is to transform the experience for both patient and clinician in interventional procedures with a 3D augmented reality platform featuring real-time holographic visualization of the patient’s actual anatomy, “floating” over the patient.The visualization is fully controllable “hands-free” by the clinician, providing an ergonomic breakthrough for the treatment and analysis of cardiac arrhythmias within an interventional catheter lab environment. SentiAR is developing the platform for eventual FDA submission.
Beyeonics — Beyeonics Surgical technologies began operating in 2012, led by a team of Elbit Systems senior engineers with a mission to revolutionize the visualization and information presented during surgery. Future products include visualization systems for other surgical applications as well as solutions for spine surgery, minimal invasive procedures,robotic surgery and use in cardiovascular catheterization labs. Operating from Israel, Beyeonics is working in collaboration with Prof. Anat Lowenstein the Head of Ophthalmic Department and Prof. Adiel Barak the Head of the Retina Department in Tel Aviv Sourasky Medical Center and with Dr. Pravin Dugel managing partner at Retinal Consultants of Arizona.

Chartered Opus offers professional market participants (clients such as asset managers) the opportunity to realise “securitised” concepts/products for their own investment or for their customers.

Investment focus

Wellness, Biotechnology, Manufacturing
Series A
Israel

Portfolio highlights

SolCold — We make the sun cool again - Solcold the new environment solutions
Trobix Bio — Trobix Bio is a company that develops and commercializes antibacterial products. It has developed platform technologies called ActiSense and GOTrap for developing high-quality products that remove the threat of antimicrobial resistance.

PipelBiz enables companies to raise capital from an unlimited number of investors without the need of a prospectus

Investment focus

Software, Health Care, Manufacturing
Funding Round, Equity Crowdfunding, Seed
Israel, United States, United Kingdom

Portfolio highlights

Vootto — Vootto is raising the bar in air purifier technology, engineered to clear the air in your car of 99.9% of airborne contaminants and germs in under 10 minutes. The best part is that you get to pick from a selection of quality scents and choose how to refresh your space. Vootto circulates the air through the scent capsule and actively freshens,unlike passive fresheners that just sit there.Vootto performs better than any other brand because of its innovative air routing system and its unique set of blades that provide the fastest rate of filtration. Not only that, Vootto’s exclusive Active Shield technology traps and destroys bacteria and viruses without releasing harmful byproducts, such as ozone or negative ions. Simply put, Vootto is in a league of its own.
Omnistream — Omnistream offers high-quality and user friendly app that produces professional video and production suit from your smartphone Omnistream empowers content creators, enabling anyone to produce high-quality and real-time video at an affordable and easy to use way
NeuroSense Therapeutics — NeuroSense Therapeutics Ltd., is a clinical-stage biotechnology company, dedicated to the discovery and development of treatments for debilitating neurodegenerative diseases. Its lead product, PrimeC, is a novel oral therapy for the treatment of amyotrophic lateral sclerosis (ALS). The company's preclinical pipeline includes: (1) StabiliC forthe treatment of Parkinson's disease and (2) CogniC for the treatment of Alzheimer's disease. NeuroSense Therapeutics Ltd. was incorporated in 2017 and is headquartered in Herzliya, Israel.

Aster is a Venture Capital firm with offices in 4 major innovation hubs: Paris, London, Tel Aviv and San Francisco. Since 2000, they have partnered with more than 60 teams of entrepreneurs that are transforming markets with disruptive offers and technologies. They are always open to exploring new ideas related to mobility, energy and industrysectors that they have been covering until now. They invest in all stages, with a preference for the early phase.They are more than investors and they intend to act as an ally for entrepreneurs by connecting them to a valuable ecosystem of experts, influencers and business leaders. From marketing to executive talent, their commitment to the growth of their portfolio companies as well as the entire venture ecosystem also involves the commitment of their dedicated Operations team, their innovation strategy consulting firm (Aster Fab) and a crowdfunding branch to further expand opportunities (Aster Crowd).Some of their success stories include Solairedirect (acquired by Engie in 2015), Digital Lumens (acquired by Osram in 2017) and Avantium (IPOed in 2017).

Investment focus

Software, Energy, Manufacturing
Series A, Funding Round, Series B
France, United States, United Kingdom

Portfolio highlights

Otoqi — Otoqi is a vehicle delivery platform that develops connected services and logistics solutions for the automotive professionals.
Neural Concept — Neural Concept is the first AI software for enhanced engineering. Leverage your historical CAD and CAE data to drastically shorten and improve your design cycles.
LevelTen Energy — LevelTen Energy provides transaction infrastructure for buyers, sellers, advisors, and financiers in the renewable energy economy.

Israel Biotech Fund – Building the future of Israeli BiotechIsrael Biotech Fund seeks high value returns by identifying and maximizing the success of therapeutic assets of Israel-based biotech companies.Based in Rehovot, Israel’s main Biotech hub, we invest exclusively in Biotech companies developing drugs at or near clinical stages.Ourpartners include two top-tier international pharmaceuticals companies, institutional investors, family offices and high net worth individuals.Our key asset is a unique team of 25 Venture Advisors, comprised of renowned industry leaders and professionals who, together with the fund’s managing partners, provide our portfolio companies with hands-on guidance and support.We don’t just invest in promising companies – we have the ability, experience and network required to identify the best opportunities and partner with our portfolio companies to help them go the distance.We provide our portfolio companies with the necessary resources for long-term sustainable growth. This approach enhances their value and the investor’s long-term capital appreciation, while strengthening Israel’s Biotech industry which increases investment opportunities.The biotechnology industry in Israel is growing with enormous potential and we are determined to realize its full potential and real value.

Investment focus

Biotechnology, Pharmaceutical, Health Care
Series B, Series A, Series C
Israel, United States

Portfolio highlights

MediWound — MediWound is a biopharmaceutical company that develops, manufactures and commercializes novel, cost effective, bio-therapeutic solutions for tissue repair and regeneration.
Splisense — Splisense is develops antisense oligonucleotide based therapies to target genetic diseases caused by splicing mutations. The company has developed a compound to cure the lung disease in cystic fibrosis patients carrying a specific splicing mutation. It is also developing a targeted modulation approach to correct the splicing pattern of CFTRtranscripts according to the specific mutation carried.
Vensica Medical — Currently, after surgical removal of tumors found in the bladder, a drug is instilled into the bladder via a catheter. This treatment method is inefficient and ineffective: Urinary bladder cancer has the highest recurrence rates among all types of cancer (70%).Using Vensica’s device, the drug will be instilled in a quick, pain-free proceduresubsequent to the delivery of ultrasound to the urinary bladder. Ultrasound improves the uptake of the drug and its penetration into the bladder wall and is expected to improve the treatment and reduce recurrence rates.

Sanara Ventures is an innovation-investment platform, elevating outstanding healthcare-technology companies, from early-stage to global market maturity. At Sanara, They share a vision of an integrated continuum of care supported by accessible advanced healthcare solutions for people around the world.

Investment focus

Health Care, Medical, Medical Device
Seed, Series A, Funding Round
Israel

Portfolio highlights

QTflow Ltd. — A Micro Air Pump Technology: The Future of Thermal Management
CVAid Medical — CVAid Medical develops an innovative AI based stroke detection technological platform.
TailorMed — Moving Mountains for Patients

Ziegler is a privately held investment bank, capital markets and proprietary investments firm.

Investment focus

Health Care, Biotechnology, Mobile
Series C, Series E, Series F
United States, Israel

Portfolio highlights

Aposense — Aposense (formerly NST) is a clinical-stage molecular imaging and drug development company, with a pipeline of products based on its patented platform technology for targeting apoptosis (programmed cell death) in vivo. The company translating the science of Apoptosis (programmed cell death) into personalized patient care in multiple diseasecategories, including oncology, cardiology, and neurology. Targeting of this important biological process in-vivo opens opportunities for real-time clinical imaging of disease activity and targeted therapy.Aposense specializing in the development of novel drugs and utilizing membrane electrical forces for trans-membrane of macromolecule drugs, mainly siRNA. It also developed rationally-designed molecular nano-motors (MNMs), being novel small-molecule chemical entities and its translation into kinetic energy for movement within the hydrophobic membrane core.Aposense was founded in 1996 and is headquartered in Petah Tiqva, HaMerkaz, Israel.
MAKO Surgical — MAKO Surgical is a medical device company, markets its advanced robotic arm solution, joint specific applications for the knee and hip, and orthopedic implants for orthopedic procedures in the United States and internationally. The company offers MAKOplasty, a restorative surgical solution that enables orthopedic surgeons to treat patient specificosteoarthritic disease. It also provides robotic arm interactive orthopedic system (RIO) consisting of a tactile robotic arm utilizing an integrated bone cutting instrument; and a patient specific visualization component, which offers pre-operative and intra-operative guidance to the orthopedic surgeon, enabling tissue sparing bone removal, and accurate implant insertion and alignment.In 2011, The company was named the No.1 on the Technology Fast 500 as the fastest growing technology company by Deloitte and received the CSSEC Award for loyal, customer-focused staff members presented by the Technology Services Industry Association and ACE Award (Achievement in Customer Excellence) from MarketTools and Fast Tech Award as one of the 25 fastest growing technology companies in South Florida by South Florida Business Journal.MAKO Surgical was founded in 2004 and is headquartered in Florida, USA.
MobileAccess Networks — Corning Everon Network Solutions offer in-building cellular solutions to meet a broad array of design scenarios and mitigate RF propagation challenges.

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