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Top 50 Biotech Startup Investors in Italy in April 2025

Last updated: Apr 2025 A list of 50 angel investors and VC (Venture Capital) funds that invest in Biotech startups based in Italy. We rank investors based on the number of investments they made in Biotech companies from Italy. We update this investor list every month.

Top 50 Biotech Startup Investors in Italy in April 2025

Investor	Biotech Italy investments
Sofinnova Partners	11
Italian Angels for Growth	9
CDP Venture Capital	7
Indaco Venture Partners	7
Vertis	7
LIFTT	6
Principia SGR	6
Innogest Capital	5
Green Arrow Capital	4
A11 Venture	4
Progress Tech Transfer Fund	3
INGENIUM Emilia Romagna	3
Invitalia Ventures	3
Club degli Investitori	3
Claris Ventures	3
Eureka Venture	3
Atlante Ventures	3
Stefano Bernardi	2
Intesa Sanpaolo	2
Kering Ventures	2
Italian Angels for Biotech	2
Barbara Castellano	2
UniCredit	2
StartUp Health	2
3LB Seed Capital Srl	2
Lazio Innova	2
3B Future Health Fund	2
European Investment Bank	2
Banco BPM	2
Panakes Partners	2
European Circular Bioeconomy Fund	2
Enrico Pandian	1
Ambienta	1
Longwood Fund	1
V-Bio Ventures	1
Seroba Life Sciences	1
MPM Capital	1
RECOMEC	1
VI Partners	1
United Ventures	1
Scientifica Venture Capital	1
Elena Paola Lanati	1
Cube Labs	1
Spindial Group	1
EIC Fund	1
Utopia	1
Istituto Nazionale Biostrutture e Biosistemi	1
a\|impact	1
Pi Campus	1
Riso Gallo	1

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Investor list

Sofinnova Partners is a leading European venture capital firm in life sciences, specializing in healthcare and sustainability. Based in Paris, London and Milan, the firm brings together a team of professionals from all over the world with strong scientific, medical and business expertise.

Investment focus

Biotechnology, Health Care, Medical
Series A, Series B, Series C
France, United States, United Kingdom

Portfolio highlights

Bioptimus — Our mission is to build the first universal AI foundation model for biology to fuel breakthrough discoveries and accelerate innovations in biomedicine and beyond.
Latent Labs — Latent Labs is making biology programmable to transform health and sustainability for the benefit of all.We are a frontier AI lab building foundational models that capture the fundamentals of biology. We empower partners with breakthrough generative AI to gain unprecedented control over molecular biology, creating new antibodies, optimizingexisting enzymes, and advancing genetic engineering.Contact us to work with us today.
Berry Street — Nutrition therapy by registered dietitians covered by insurance.

IAG is an angel investor network that offers access to its affiliates to early-stage venture opportunities. Its members to date have deployed over 22 million Euros to support 41 startups in the series seed/series A stage in many verticals, among which: Medtech, SAAS, e-commerce, Fintech, and high tech at large. Every investment opportunityat IAG is vetted by a professional team together with expert members of the group. Once invested, the company receives the support of up to two Investment champions, who bring their expertise to the table and help them succeed.

Investment focus

Software, E-Commerce, Health Care
Seed, Angel, Series A
Italy, United States, United Kingdom

Portfolio highlights

ALKemist Bio — ALKemist Bio provides cell treatment to cancer patients.
Rubedo Life Sciences — Rubedo Life Sciences is the Premier Longevity Company. Rubedo discovers and develops medicines to keep you biologically young.
Restorative Neurotechnologies — Siamo un'azienda di dispositivi medicali certificati per la riabilitazione cognitiva ed il trattamento di disturbi cognitivi post ictus.

CDP Venture Capital Sgr - National Innovation Fund aims to make venture capital a cornerstone of the country's economic development and innovation, creating the conditions for an overall and sustainable growth of the venture capital ecosystem.

Investment focus

Software, Information Technology, Health Care
Seed, Series A, Funding Round
Italy, United States, Germany

Portfolio highlights

Mopso — Discover Mopso's anti money laundering detection system. Visit our website and try a 30 minutes free demo with one of our experts.
Postura Ergonomics — Postura transform workers videos into ergonomic risk assessments for manufacturing companies. Our AI delivers quick, accurate, and scalable analyses, cutting costs and compliance time. ergonomia lavoro ufficio
Genoa Instruments — Genoa Instruments is an innovative startup dedicated to transforming the field of biomedical and health research through advanced super-resolution optical microscopy. Our groundbreaking optical microscope uniquely integrates spatial and temporal super-resolution for structural and functional imaging in living samples with unprecedented detail. Ourmission is to make high-resolution imaging accessible to all, fostering scientific discovery and advancing healthcare research.

VENTURE We invest across all sectors with specific focus on technology and digital The largest independent more About Us Portfolio [...]

Investment focus

Biotechnology, Health Care, Medical
Series A, Series B, Series C
Italy, Switzerland, United States

Portfolio highlights

D-Orbit — End-to-end services for the New Space industry, including platform engineering, launch and deployment, and decommissioning.
MicThera — MicThera focuses on developing microbial-derived therapeutics to provide effective treatments for prostate cancer patients, aiming to find effective solutions for medical companies.
Genespire — Genespire is a biotechnology company focused on the development of transformative gene therapies for patients affected by genetic diseases, particularly primary immunodeficiencies and inherited metabolic diseases.

Vertis is a dynamic and independent investment management company authorised by Bank of Italy. It manages five closed-end funds for qualified investors by participating in research projects, spin-offs, startups and PMI and deals with the investments of the innovative Made in Italy.

Investment focus

Software, Health Care, Biotechnology
Seed, Series A, Funding Round
Italy, United States

Portfolio highlights

Radical Storage — Find your closest luggage storage and enjoy your journey until the very end!
Focoos AI — Focoos reshapes computer vision with ultra-efficient models that drive down costs, automate hardware integration, and ensure peak performance on any device, while promoting sustainability.
TimeFlow — TimeFlow is a software that acts as a B2B marketplace dedicated to the technical and managerial consulting sector.

A not-only-profit operating investment company, eager to create a bridge between innovative ideas, territory and capital.

Investment focus

Biotechnology, Software, Information Technology
Seed, Funding Round, Series A
Italy, United Kingdom, France

Portfolio highlights

Mediaire — mediaire supports radiologists with AI-based tools for MRI reporting. This enables them to make a more accurate and objective assessment even faster.
MicroLub — MicroLub produces a fat replacement for lower-calorie plant-based diets. It is cutting-edge innovation to the next generation of protein technology, creating exclusive ingredient solutions that significantly minimize molecular friction.
Composite Research — CoRe Research is an start-up, aimed at the study of new product and process solutions in the field of composite materials.

Principia is an Italian Venture Capital firm with over Eur 80M under management. Currently Principia has two funds investing in digital start ups and expansion capital opportunities and in particular cases, we invest also in seed opportunities.

Investment focus

Health Care, Biotechnology, Software
Funding Round, Series A, Seed
Italy, United States, United Kingdom

Portfolio highlights

KLISBio — KLISBio is a medtech company currently developing a variety of regenerative medicine implantable products leveraging the power of silk fibroin to promote an endogenous repair of human soft tissues.
ENTEROME — We are a clinical stage biopharmaceutical company developing novel drugs to transform human health based on our unique ability to de-code molecular interactions in the gut microbiome.
WISE — WISE (Wiringless Implantable Stretchable Electronics) is a start-up company created in 2011 with the mission of producing the new generation of leads for neuromodulation for treatment of chronic pain and Parkinson: unbreakable, less invasive and cheaper.

We are investors in companies that make the difference. We partner with hard-working entrepreneurial visionaries

Investment focus

Health Care, Medical, Medical Device
Funding Round, Series A, Series B
Italy, United States, Spain

Portfolio highlights

GreenBone Ortho — GreenBone Ortho was founded in Faenzato offer advanced and innovative solutions in the field of orthopaedics and bone regeneration, using the Rattan wood.
Renovacor — Renovacor is a preclinical‑stage biopharmaceutical company focused on developing transformative gene therapy‑based treatments for cardiovascular disease.Renovacor’s lead program is a recombinant adeno-associated virus (AAV)‑based gene therapy for patients suffering from dilated cardiomyopathy (DCM) due to mutations in the Bcl2‑associatedathanogene 3 (BAG3) gene.Dilated cardiomyopathy is a condition affecting over 3 million patients in the US and growing steadily. Many patients develop DCM due to ischemic heart disease. Recently subpopulations have been identified that develop DCM due to mutations in specific genes that have been shown to result in the development of DCM. One of these specific genes is the BAG3 gene. The prevalence of disease‑causing BAG3 haploinsufficiency is estimated at approximately 35,000 individuals in the United States, representing an orphan disease by FDA guidelines. It is estimated a similar number of DCM patients with BAG3 mutations exist in Europe. These patients are typically younger and progress to end-stage heart failure sooner than patients with ischemic heart disease. Currently, DCM patients with a BAG3 mutation are treated with standard of care for heart failure. Despite improvements in pharmacotherapy and care, the five‑year survival of a patient with DCM is only 50%. The development of a BAG3 gene replacement therapy for patients with DCM that carry BAG3 mutations could potentially prevent the progression of disease in this otherwise healthy population of young adults.
BetaGlue Technologies — BetaGlue Therapeutics is a life sciences company that delivers radiotherapy from within. Introducing Yntradose, our proprietary product.

Green Arrow Capital is an independent financial group specializing in alternative investments across Europe. They represent a one-of-a-kind platform, capable of connecting the financial system with the real economy through the management of private equity, private debt, infrastructure, and special credit situation funds as well as thematic fundssuch as microfinance and funds of funds that are currently under management. Their team has a successful track record in asset management, investment banking, industry sectors, technology startups, management consulting, renewable energy, and has government and regulatory experience. Their group is mainly composed of investment, asset management, and financial advisory companies. Their aim is to create a solid financial platform to launch and manage investment funds dedicated to alternatives and to the real economy.

Investment focus

Health Care, Biotechnology, Manufacturing
Funding Round, Seed, Series A
Italy, United Kingdom

Portfolio highlights

Cogisen — Cogisen develops artificial intelligence solutions. It offers SENCOGI, an eye-tracking software for smartphones/mobile phones. Chiara Passacantilli and Christiaan Erik Rijnders founded Cogisen in 2009. Its headquarters is in Naples in Italy.
Directa Plus — Directa Plus is a nanotechnology company, manufactures nanoparticles.
Glomeria Therapeutics — Glomeria Therapeutics researches, develops, and markets new medical devices for the treatment of serious diseases in the nephrological area. It offers DesmoPD, peritoneal dialysis connection system; SmartPD, an automated management device for peritoneal dialysis solutions to be instilled in peritoneum; and solutions for peritoneal dialysis.Andrea Zanella founded Glomeria Therapeutics in 2010. Its headquarters is in Chieti in Italy.

A11-Venture investe nel capitale di startup innovative nei settori della robotica, automazione, meccatronica, cleantech, web e IT. Facilita la nascita e lo sviluppo di business innovativi globali per il futuro dell'economia locale. Contribuisce a costruire aziende, lavoro qualificato, brevetti, innovazione capaci di rilanciare e riportareinvestimenti e risorse sul territorio. I soci di A11 Venture credono fermamente nell’innovazione grazie a ciò è possibile crescere per linee esterne diversificando i propri investimenti, grazie ad un portafoglio di imprese, con una forte risk mitigation derivante dalla gestione professionale di tutti processi: scouting, team building, investimenti, management degli investimenti, accelerazione e disinvestimento.

Investment focus

Biotechnology, Medical Device, Health Care
Seed, Pre-Seed, Series A
Italy, United States

Portfolio highlights

Reefilla — Reefilla EV charging services: recharge your car anywhere, anytime
Endostart — Endostart development and manufacturing of a new generation medical devices for gastrointestinal endoscopy.
Neuron Guard — Neuron Guard, recognized as the best European startup in HEALTH category (Startup Europe Awards - SEUA 2017), is developing a life-saving medical device that aims to become the standard of care for Targeted Temperature Management (TTM) therapy. Every 7 seconds around the world a person suffers of Acute Brain Damage because of CardiovascularDiseases (CVD) and Traumatic Brain Injury (TBI). They are the most costly and prevalent killers in the last 15 years (15 million deaths by CVD in 2015), and the leading cause of disability (the global incidence rate of TBI is 200 per 100k people per year). WHO estimated a global expenditure of $ 330 billion in 2015, but it is going to increase sharply: $ 4 trillion in 2025 - including premature death, disability, and health care costs - just for CVD in LMICs. Temperature is a vital body parameter. It regulates all cellular functions so its management is essential for the good outcome of patients in several medical conditions such as cardiac arrest, stroke, traumatic brain injury, neuro and cardiac surgery, epilepsy, migraine and oncology. Regulating body temperature at a desired level makes all other treatments more effective. The most modern medical approach is the target temperature management, where physicians try to maintain the most favourable temperature for the patient for up to 24-36 hours, preventing excessive warming (fever) or cooling.Our device is a targeted temperature management system composed by a THERAPEUTIC COLLAR POWERED BY A SMART CONTROL UNIT (the size of a small briefcase). The collar transforms the neck into a natural heat exchanger exploiting several physiological and anatomical characteristics of the human body. It is quicker to act on brain tissue but can also function as total body temperature adjusting device if required. A disposable protective shield makes cleaning the collar after each use simple while featuring an optimal safety profile both in term of pathogens and allergens. The control unit collects all the data of the treatment and transmits them to the Emergency Response System. Our mission is to improve the safety of patients on the roadside, at home or in the workplace, and to reduce the costs of chronic care. In fact, Neuron Guard aims to be the only device that can be used in every circumstance, inside and outside the hospital, and allow the user to fully manage the temperature of the patient warming and cooling as necessary. Our vision is to have a Neuron Guard kit in every public place just like the Automatic External Defibrillator (AED) to empower bystanders to immediately react in case of emergency. Under this perspective our device becomes a connected-intelligent platform that takes care of the patient, connects the scene with the Emergency Response System transmitting vital data to improve the readiness and effectiveness of professional intervention.The device is patented in Italy, USA and China. We have made several prototypes in collaboration with Italian and English companies, such as Tecno Elettra Impianti and TWI, tested it in laboratory and published the experimental results on the NeuroCritical Care Journal. We have also conducted a GAP Analysis with another English consulting firm (CDP) and we are testing the human prototype internally. We are seeking to raise 2.5M€ to complete the pre-industrialization, with design and construction of the human device for the pilot trial, finalized the regulatory clearance and launch it into the market in 2019.

Investment fund specialized in sustainable technologies from universities and public research organizations, start-ups, spin-offs, and entrepreneurs.

Investment focus

Biotechnology, Water, Manufacturing
Series A, Seed, Funding Round
Italy, Ireland, United Kingdom

Portfolio highlights

WembraneX — WembraneX's goal is to make wastewater treatment facilities more cost-effective by introducing a new class of anti-fouling and anti-biofouling membranes.
Naturbeads — Naturbeads creates biodegradable, sustainable and cost competitive cellulose microbeads to replace currently used microplastics.
Valuematic — Valuematic realizza soluzioni per il trattamento e gestione dei dati favorendo il miglioramento nei processi organizzativi e informativi di aziende ed enti.

INGENIUM Emilia Romagna was started with EUR 5.30 million by the Emilia Romagna region and EUR 1.7 million from fund managers. Managed by META Investment, the nine-year fund operated through the temporary acquisition of minority stakes in high-opportunity technological companies. It is now fully invested.

Investment focus

Medical, Health Care, Privacy
Seed, Angel, Funding Round
Italy

Portfolio highlights

CellPly — Cellply is a life-science company focused on developing next-generation analytical tools enabling a deep characterization of cancer immunotherapies, cell therapies and cell-based biotherapeutics. The company aims to support the development of novel cancer immunotherapies by accelerating R&D, automating the quality control and advancing theability to monitor the clinical response to these treatments.Through the use of proprietary microfluidic technologies with Co-Culture Array technology, highly-automated analytical instruments and AI-powered image and data analytics, Cellply products define the function of the immune system one cell at a time, combining functional data with other multiplex data and providing unprecedented single-cell analytical solutions.
GreenBone Ortho — GreenBone Ortho was founded in Faenzato offer advanced and innovative solutions in the field of orthopaedics and bone regeneration, using the Rattan wood.
Angiodroid — Angiodroid srl, a medical technology company, focuses on hemodynamics, vascular surgery, and interventional radiology. It offers an automatic injection system for carbon dioxide angiography. Its products include carbon dioxide injector that is used as a contrast medium for pheriperal interventional angiography; and a single use kit, which iscomposed of French catheters and a custom connection line. The company is based in San Lazzaro di Savena, Italy.

Invitalia Ventures SGR manages the “Italia Venture Fund I”, a 87€/Ml sized co-investment fund that invests in early stage operations in Italy. They co-invest up to a maximum of 70% in round A (€ 0.5ML - € 1.5ML) in high growth sectors. Invitalia Ventures, with its network of co-investors not only provides risk capital, but also know-how and anetwork for business development. Main LPs includes the Ministery of Economic Development, the European Investment Bank, Cisco Group, the Sardinian Banking Foundation and Metec Group.They are looking for visionary entrepreneurs who share their passion for innovation. Growth is their mission!!For more information please contact us at info@invitaliaventures.it or visit our website: www.invitaliaventures.it

Investment focus

Software, Medical, Health Care
Series A, Funding Round, Seed
Italy, United States, United Kingdom

Portfolio highlights

Ecomate — The ESG Rating platform for every company
BigProfiles — A deep understanding of customers let a company tailor marketing campaigns and CRM strategies, but companies have only basic data about customers (e.g. gender or age). External data sources like Social Networks, Public Registries and Socio-Demographic data contain rich information about billions of people, like job titles, levels of education,interests and habits.BigProfiles is a Customer Intelligence SAAS that leverages external information about persons to enrich customer profiling: it can profile a company's customers with previously unknown information about them. Thanks to its Identity Resolution algorithm (the result of a PHD), it identifies a person’s information scattered among external sources.Through this technology, BigProfiles provides customer base analytics and behavior predictions: using Artificial Intelligence on enriched profiles allows to predict churn, fraud and willingness to buy.
Codemotion — Codemotion is the ecosystem devoted to innovation, focused on developers and coding, open to all programming languages and technologies. Pioneering spirits, it scout the future to deliver a first class experience to our people. Codemotion is one of the biggest tech-conferences in Europe, with an international network of 30.000 developers and 350speakers coming from all over the world and from the most important IT realities.Codemotion draw in its main conferences, thousands of attendees eager to discuss about hottest topics: it tailor for them disruptive proposals ranging from mobile to UX, develops, cloud, big data, gamedev, security, methods, languages, web, Internet of things. Codemotion is also a startup, providing a bunch of services and activities, for personal and business customers.

Club degli Investitori (Investors Club) is a network of investors and business angels that invest on early-stage SMEs and startups. The community of 300+ Members (entrepreneurs, CEOs, executive managers) actively scouts for investing opportunities on SMEs & startups and invests with a minimum ticket of €200k. The Club supports business byinvesting capital and by leveraging the Members' network and experience.Club degli Investitori is supported by Unicredit and KPMG Italy.

Investment focus

Health Care, E-Commerce, Information Technology
Seed, Series A, Series B
Italy, Switzerland, United Kingdom

Portfolio highlights

Stema — It serves as a platform for hiring engineers
Approxima — Approxima medical is developing a novel treatment for patients with tricuspid valve regurgitation
Lymphatica Medtech — Lymphatica Medtech is a medical device development company developing a minimally invasive solution for chronic lymphedema.Lymphedema is the chronic swelling that generally occurs in the arms or the legs.Lymphedema is most commonly caused by the removal of or the damage to the lymph nodes as a part of cancer treatment. It results from ablockage in the lymphatic system, which is part of the immune system. The blockage prevents the lymphatic system from draining excess fluids, and the fluid buildup leads to swelling, infections, and pain.Unfortunately, there is no cure for lymphedema. It can be managed with early diagnosis and diligent care of the affected limb, through daily compression, bandages, and manual drainage sessions. From the moment of the diagnosis, the life of lymphedema patients changes forever.Cancer and cancer-related interventions (i.e. surgery, radiotherapy) are frequent causes of lymphedema occurring both in the upper and lower limbs. Breast cancer survivors are at high risk for developing lymphedema, as well as patients treated for melanoma, pelvic and head and neck cancer or other cancer treatments that require lymph node dissection. Physical trauma can also result in lymphedema, a major cause of lymphatic disease among wounded veterans.Lymphedema is associated with significantly impaired quality of life, skin changes, increased risk of infection and in rare cases lymphedema itself may undergo malignant transformation.Lymphatica offers a permanent solution that will allow patients to regain their normal lifestyle.

Claris Ventures is a venture capital firm supporting the best scientists in building successful life sciences companies that will impact people's lives

Investment focus

Biotechnology, Health Care, Therapeutics
Seed, Series A, Series B
Italy, United Kingdom

Portfolio highlights

NeoPhore — NeoPhore targets the dynamics of cancer neoantigen evolution and makes effective medicines that will become a key part of the next-generation of cancer immunotherapies.
ALKemist Bio — ALKemist Bio provides cell treatment to cancer patients.
Repron Therapeutics — Repron Therapeutics provides treatments for solid tumor cases where radical excision is not possible and metastasis or recurrence is extremely likely.

Eureka! is the first independent Italian venture capital Asset Management company exclusively focused on deep tech investments

Investment focus

Nanotechnology, Renewable Energy, Medical Device
Funding Round, Seed, Pre-Seed
Italy

Portfolio highlights

Planckian — Charging the future by powering energy with science We explore frontiers of energy science by developing quantum...
INTA Systems — Nanotech and artificial intelligence for biomolecular analysis
BeDimensional — New Material Solution

Atlante Ventures is a leading Italian VC fund, operated by IMI Fondi Chiusi SGR, part of Intesa Sanpaolo Group.

Investment focus

Software, Biotechnology, Hardware
Funding Round, Seed, Series A
Italy, United States, Israel

Portfolio highlights

treet — Treet helps brands launch fully-branded recommerce sites where customers can buy & sell items from each other.
Newronika — Newronika restores brain and body functions with innovative technologies. We translate our deep knowledge on biosignal decoding into clinical practice, with the aim of improving treatments, health, and wellness. With our revolutionary brain devices, the patient receives the right stimulation at the right moment, thus becoming able to perform normaldaily activities and improve quality of life. Newronika is the spin-off company of two leading research institutions in Italy, the Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Hospital and the University of Milan. Newronika comprises a multidisciplinary team formed from Neuroscience research groups and involves scientists with expertise in neurophysiology, neurology, biomedical engineering, neuropsychology, bioinformatics, and biotechnologies.
WISE — WISE (Wiringless Implantable Stretchable Electronics) is a start-up company created in 2011 with the mission of producing the new generation of leads for neuromodulation for treatment of chronic pain and Parkinson: unbreakable, less invasive and cheaper.

Stefano Bernardi is the Investment Director, Climate at Fondazione ENEA Tech.

Investment focus

Biotechnology, Software, Artificial Intelligence
Seed, Pre-Seed, Funding Round
United Kingdom, Italy, France

Portfolio highlights

Freatic — Building the monetization layer for your alpha
CaSRevolution — A novel disease-modifying approach against neurodegeneration
Automated Architecture — A global ecosystem of automated micro-factories, to deliver sustainable, affordable and beautiful architecture to millions of people.

Intesa Sanpaolo is a banking group that specializes in wealth management, protection, advisory, and digital orientation. Their products and services include accounts, cards, loans, mortgages, insurance, digital payments, retirement planning, investments, and consulting.

Investment focus

Financial Services, FinTech, Renewable Energy
Debt Financing, Post-IPO Debt, Series A
Italy, United Kingdom, United States

Portfolio highlights

La Doria — La Doria is a producer and sells tomato derivatives, ready sauces, preserved legumes, fruit juices, and beverage products. They offer products that include boiled legumes, baked beans, red kidney beans, carrots, ready-made soups and stews, and canned pasta in tomato sauce.
MODIFI — Explore digital trade finance and B2B payment solutions that empower your business to grow globally.
Aldar Properties — The company has developed some of Abu Dhabi’s most iconic and complex projects, from the Formula 1 facilities on Yas Island to the thriving new Shams Abu Dhabi community on Reem Island. Its property portfolio is diversified and balanced, with residential communities accounting for around half of assets, retail property representing a third, and theremainder split between commercial and hospitality.

Kering Ventures is the venture investment arm of the Kering Group, acquiring minority holdings in startups.

Investment focus

Biotechnology, Interior Design
Series A
Italy

Portfolio highlights

MOGU — By employing one of its finest technologies, mycelium, Mogu delivers responsible products for interior design. Mycelium design with Mogu.
SQIM — SQIM is a biotechnological based agency.

Angel group focuses on biotech

Investment focus

Health Care, Biotechnology, Pharmaceutical
Seed
Italy

Portfolio highlights

MgShell — MgShell offers intraocular devices for the treatment of age-related macular degeneration and other ocular diseases. Their technology is the only technical solution capable of replicating current clinical practice with a single injection and releasing the same therapeutic drug doses at predetermined periods, autonomously and without surgicalprocedures.
CaSRevolution — A novel disease-modifying approach against neurodegeneration
Metis Precision Medicine — Metis Precision Medicine is a B-Corp founded with the vision of bringing powerful cancer therapies to patients in need. Metis owns the intellectual property of a suite of anti-Met monoclonal antibodies (mAbs), with different and unique mechanisms of action, and is currently seeking investors, biotech or pharmaceutical companies interested inacquiring the relevant platform technology on a global basis.

Laura Iris Ferro

Investment focus

Health Care, Biotechnology, Medical Device
Pre-Seed, Funding Round
Italy

Portfolio highlights

Newronika — Newronika restores brain and body functions with innovative technologies. We translate our deep knowledge on biosignal decoding into clinical practice, with the aim of improving treatments, health, and wellness. With our revolutionary brain devices, the patient receives the right stimulation at the right moment, thus becoming able to perform normaldaily activities and improve quality of life. Newronika is the spin-off company of two leading research institutions in Italy, the Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Hospital and the University of Milan. Newronika comprises a multidisciplinary team formed from Neuroscience research groups and involves scientists with expertise in neurophysiology, neurology, biomedical engineering, neuropsychology, bioinformatics, and biotechnologies.
Bio4Dreams — Il primo incubatore italiano certificato di startup innovative in fase very early stage, a capitale totalmente privato, dedicato alle Scienze della Vita.
CorFlow Therapeutics AG — CorFlow Therapeutics is a medtech startup that develops proprietary technologies for diagnosis and treatment of microvascular obstructions in heart attack patients. The CorFlow technologies enable interventional cardiologists to diagnose and treat MVO in severe heart attack patients thereby potentially reducing the short- and long-term complicationrates in these patients.

UniCredit (formerly UniCredito) is an Italian global banking and financial services company. Its network spanning 50 markets in 20 countries, with more than 9,000 branches and over 148,000 employees. Its strategic position in Western and Eastern Europe gives the group one of the region's highest market shares.

Investment focus

Energy, Manufacturing, Financial Services
Debt Financing, Post-IPO Debt, Funding Round
Italy, Germany, Sweden

Portfolio highlights

La Doria — La Doria is a producer and sells tomato derivatives, ready sauces, preserved legumes, fruit juices, and beverage products. They offer products that include boiled legumes, baked beans, red kidney beans, carrots, ready-made soups and stews, and canned pasta in tomato sauce.
Unifiber — Unifiber is a broadband service company that focuses on the creation of passive access fiber optic networks.
ambrogio transporti — ambrogio transporti is a intermodal transportation company.

Organizing and investing in a global army of entrepreneurs committed to achieving health moonshots

Investment focus

Health Care, Wellness, Medical
Seed, Funding Round, Pre-Seed
United States, Canada, United Kingdom

Portfolio highlights

AvoMD — AvoMD is reimagining clinical decision support with interactive point-of-care software, available standalone and via EHR integrations, and seamless content building tools.
Pear Suite — Pear Suite empowers community health workers with technology, education, and community, helping them do their best work and serve their communities.
Hidoc Consult — Hidoc Consult: Boost your well-being with free consultations, 24/7 access to quality healthcare, complete privacy, user-friendly, and a trusted network of HCPs

3LB Seed Capital is not an alternative to start-ups incubators and accelerators, rather acts as a complementary reality that helps to enhance your project in terms of attractiveness for the investor and venture capital market.As investors they are the first willing to know if your project has what it takes to grow successfully. If they areconvinced of your potential, they are ready to bet on you, by joining you and helping you to develop your project.3LB Seed Capital does not provide a percentage of equity in exchange for accompanying activities, but relies exclusively on a premium at the time of its first direct investment in your company.

Investment focus

E-Commerce, Software, Information Technology
Seed, Pre-Seed, Series A
Italy, United States, United Kingdom

Portfolio highlights

YoAgents — Yo Agents nasce dalla unione delle competenze di ogni singolo founder messe a fattor comune per creare un sales hub innovativo.
Botsociety — Your conversational design suite. Design and prototype your next chatbot or voice assistant. Create a mockup of your project on Messenger, Slack, Google Assistant, Alexa and more. The next generation design solution for chatbots and voice.
Metis Precision Medicine — Metis Precision Medicine is a B-Corp founded with the vision of bringing powerful cancer therapies to patients in need. Metis owns the intellectual property of a suite of anti-Met monoclonal antibodies (mAbs), with different and unique mechanisms of action, and is currently seeking investors, biotech or pharmaceutical companies interested inacquiring the relevant platform technology on a global basis.

Lazio Innova is a venture capital firm with its headquarters in Rome in Italy. The firm provides services in areas such as credit support and guarantees, interventions in risk capital, internationalization services, promotion of business networks and services for the creation and enterprise development.

Investment focus

Software, Health Care, Artificial Intelligence
Seed, Pre-Seed, Grant
Italy, United Kingdom

Portfolio highlights

Joinrs — We developed an artificial intelligence model able to read job offers for you and show you the ones that best match your profile.
Medicud — Medicud develops a device for treating wounds with negative pressure dressing.
Ticketoo — Ticketoo: compra e vendi biglietti fan-to-fan in modo sicuro

Helsinn Investment Fund S.A. is a Luxembourg fund focused on early-stage investments in areas of high unmet patient need.

Investment focus

Biotechnology, Therapeutics, Medical
Series B, Series A, Funding Round
United States, Italy, United Kingdom

Portfolio highlights

NeoPhore — NeoPhore targets the dynamics of cancer neoantigen evolution and makes effective medicines that will become a key part of the next-generation of cancer immunotherapies.
Fore Biotherapeutics — We are a precision oncology company pioneering the development of cancer therapies guided by our proprietary functional genomics.
On Target Laboratories — ON TARGET LABORATORIES discovers and develops fluorescent markers to target and illuminate cancer during surgery so it can be removed more completely.

The European Investment Bank (EIB) offers lending, borrowing, and treasury services primarily within the European Union. It provides project loans for public and private sectors, loans to banks and intermediaries, structured finance products, guarantees, and securitization instruments for debts. Additionally, EIB offers equity and fund investmentproducts, including infrastructure and environmental funds, as well as venture capital funds. EIB also supports microfinance and risk-sharing finance for research and innovation and provides technical expertise for sustainable energy projects. Its services include infrastructure advisory, urban development support, guarantees for transport infrastructure, and funding for public-private partnerships and small- to medium-sized enterprises. The bank serves various sectors, including transportation, energy, health, education, and agriculture.

Investment focus

Biotechnology, Health Care, Energy
Debt Financing, Post-IPO Debt, Funding Round
Germany, France, The Netherlands

Portfolio highlights

Amadix — Amadix develops and commercializes breakthrough discoveries in cancer diagnosis with a clear commercial rationale, addressing unmet medical needs in oncology. After analytical validation and demonstration of clinical validity and utility through international multicentre studies, the products will be commercialized worldwide.The most advancedproduct developed by Amadix is Colofast, an innovative non-invasive screening signature for colorectal cancer (CRC) and advanced adenoma diagnosis in blood designed to solve a significant health priority: the high mortality rate due to colon cancer worldwide (around half of the diagnosed patients).Amadix team consist of industry veterans with robust expertise in the Oncology Diagnostic area. They are a top level management team with international experience in cancer diagnostics, the pharmaceutical industry, the biotechnology sector and intellectual property. Amadix also has independent board members with international profiles and many years of experience in oncology and diagnostics, who advise the management team on strategy, commercialization and business development in Europe and the US.
Greenlight Biosciences — Next Generation Crop Protection
Azienda Comprensoriale Acquedottistica — ACA Spa is an integrated water service company.

Scopri i servizi bancari e finanziari di Banco BPM: conti, mutui, carte, prestiti, assicurazioni, trading e tanto altro. Per privati e imprese.

Investment focus

Manufacturing, Product Design, Energy
Debt Financing, Post-IPO Debt, Pre-Seed
Italy, United States, Spain

Portfolio highlights

Maire Tecnimont — We are enablers of innovation, working alongside businesses to develop sustainable technologies and design integrated solutions that inspire energy transition.
Enel Green Power — Enel Green Power is the company that deals with renewable energy from every perspective: from direct sales through PPA, to commitment at the forefront with its plants worldwide.
Garofalo Health Care — Garofalo Health Care SpA is a major group in Italy in the authorized private healthcare sector and the only Italian firm listed on the Star division of the Italian Stock Exchange in the healthcare industry.

Panakès Partners is a Venture Capital firm, based in Milan, which invests in the most ambitious companies and teams, developing revolutionary technologies and products, in the field of life sciences, aiming to improve the lives of people around the world. Panakès, founded in 2015 by Fabrizio Landi, Alessio Beverina and Diana Saraceni, has 250million under management.

Investment focus

Health Care, Medical, Medical Device
Series B, Series A, Seed
Italy, Switzerland, United Kingdom

Portfolio highlights

Relief — RELIEF s.r.l. aims at introducing on the market miniaturized devices for the treatment of urinary incontinence. In particular, the company proposes a technology that is simple, highly innovative, unisex, effective, low-cost and acceptable from the patient viewpoint.
Approxima — Approxima medical is developing a novel treatment for patients with tricuspid valve regurgitation
Neuromod Devices — Neuromod is a medical device company formed to advance the science of bi-modal neuromodulation.We are committed to delivering treatments that significantly reduce the suffering of underserved patient populations who live with chronic and debilitating conditions globally. Our goal is to design products that empower patients to take control oftheir own treatment, delivering targeted therapies that integrate seamlessly into a modern lifestyle.Neuromod has developed and patented a bi-modal neuromodulation technology that it is evaluating for neurological disorders including chronic tinnitus, a condition affecting 10% of the adult population and commonly known as 'ringing in the ears'.

European Circular Bioeconomy Fund invest and partner with entrepreneurs to accelerate late-stage circular bioeconomy companies.

Investment focus

Biotechnology, AgTech, Agriculture
Series B, Series A, Series C
The Netherlands, France, Italy

Portfolio highlights

OroraTech — From safeguarding forests and ecosystems to protecting communities and critical assets, OroraTech's advanced technology and reliable insights address challenges, mitigate risks, and drive meaningful impact.
Elicit Plant — We work with farmers around the world to meet the challenges of climate change and the impact of water scarcity on field crops.
watttron — Watttron invents a revolutionary heating system that can heat up surfaces heterogeneously.Watttron develops an innovative heating technology that can be used in various industrial processes. It is superior to current heating systems in many ways and offers a number of advantages. On the following pages, you will find information about possibleapplications and opportunities.The company is located in the Technologie- und Gründerzentrum Freital – a technology and start-up center on the outskirts of Dresden, the state capital of Saxony.

Enrico Pandian is the Co-Founder and CEO of StartupGym and the Founder of FrescoFrigo. He previously worked at Checkout Technologies as a Co-Founder and President of the Board. Enrico Pandian attended the University of Verona.

Investment focus

E-Commerce, SaaS, Pharmaceutical
Seed, Angel, Pre-Seed
Italy, United States

Portfolio highlights

Quisto — On Quisto, Ho.Re.Ca. retailers can find the best suppliers in their area and purchase 24/7 whatever they need for their business --> www.quisto.it
CaSRevolution — A novel disease-modifying approach against neurodegeneration
Viceversa — Viceversa provides capital to European digital businesses to support companies in sustainable and ethical growth. The company was founded in 2021 and has locations in Milan and Dublin.

Founded in 2007, with offices in Milan, Munich, London and Paris Ambienta is a leading asset manager entirely focused on investments driven by environmental sustainability key drivers, Resource Efficiency and Pollution Control

Investment focus

Manufacturing, Energy, Renewable Energy
Private Equity, Funding Round, Series A
Italy, United Kingdom, Germany

Portfolio highlights

Caprari — Caprari design, production, and distribution of centrifugal pumps and motors for the integrated water cycle.
Nactarome — Nactarome are manufacturer and producer of natural food flavoring components, colours, and ingredients sector.
Maccaferri — Maccaferri provides tailor-made design and development solutions for complex civil, geotechnical and environmental engineering works all around the word.

Longwood creates and invests in science-based companies that develop novel solutions for important medical problems

Investment focus

Biotechnology, Therapeutics, Health Care
Series A, Series B, Series C
United States, United Kingdom, Italy

Portfolio highlights

Evommune — Evommune is taking a tissue-based approach to advance insights and accelerate the development of transformative medicines in inflammatory diseases.
Be Biopharma — Be Bio is developing a proprietary class of engineered B cells as medicines that unleash the potential of cell therapies in applications beyond cytotoxicity.
Progentos Therapeutics — Progentos Therapeutics develops an approach to treat multiple sclerosis that stimulates the body's natural repair mechanisms.

V-Bio Ventures is an independent venture capital firm specialized in building and financing young, innovative life science companies. The fund invests throughout Europe in start-up and early-stage companies with high growth potential focusing on technologies that provide transformational improvements in the biotech, pharmaceutical and agriculturalsectors.

Investment focus

Biotechnology, Health Care, Medical
Series A, Series B, Seed
Belgium, France, United Kingdom

Portfolio highlights

AstriVax — AstriVax aims for initial clinical validation of the platform technology, to develop a broad vaccination pipeline.
Precirix — Developing radio-immunotherapeutic drugs for cancer patients.
Sibylla Biotech — Sibylla Biotech developed small molecule folding interfering degraders (FIDs) that can address a range of therapeutic areas.

Seroba is a leading European life sciences venture capital firm focused on value creation through backing winning innovations in biotech and medtech.

Investment focus

Health Care, Biotechnology, Medical
Series A, Series B, Funding Round
Ireland, United States, United Kingdom

Portfolio highlights

Shorla Pharma — Shorla Pharma is an Irish specialty pharmaceutical company. It is growing portfolio brings accessible, affordable and life-saving treatments to patients, delivering a major contribution to patient care and providing a significant clinical impact.
Vico Therapeutics — Vico Therapeutics is a developer of ribonucleic acid (RNA) modulating therapies for rare neurological disorders. The company discovers, develops, and delivers therapies for CNS disorders. Its initial focus is on SCA which is a subgroup of hereditary ataxia, HD which is a neurodegenerative disorder, and RTT-a neurodevelopmental disorder primarilyaffecting girls that enable clients with providing therapy for it.Vico Therapeutics was founded in 2019 by Luc Dochez, Josh Mandel-Brehm, Judith van Deutekom, and Gail Mandel and it is headquartered in Leiden, The Netherlands.
Artica Therapeutics — Artica Therapeutics specializes in biotechnological research and development for medical devices, pharmaceutical processes, and food.

Powering Breakthroughs in Life Sciences

Investment focus

Biotechnology, Health Care, Pharmaceutical
Series B, Series A, Series C
United States, United Kingdom, Canada

Portfolio highlights

Firefly Bio — Firefly specializes in Degrader Antibody Conjugates (DACs) which combine the unique strengths of ADCs with selective protein degraders.
Umoja Biopharma — Pioneering immunotherapy by reprogramming T cells in vivo to target cancer cells.
Frontier Medicines — Frontier Medicines is boldly advancing science to defeat disease by pioneering innovations in precision-based medicines to target undruggable therapies

RECOMEC operates as a venture capital firm that primarily invests in the healthcare sector.

Investment focus

Medical, Health Care, Biotechnology
Funding Round
Italy

Portfolio highlights

CellPly — Cellply is a life-science company focused on developing next-generation analytical tools enabling a deep characterization of cancer immunotherapies, cell therapies and cell-based biotherapeutics. The company aims to support the development of novel cancer immunotherapies by accelerating R&D, automating the quality control and advancing theability to monitor the clinical response to these treatments.Through the use of proprietary microfluidic technologies with Co-Culture Array technology, highly-automated analytical instruments and AI-powered image and data analytics, Cellply products define the function of the immune system one cell at a time, combining functional data with other multiplex data and providing unprecedented single-cell analytical solutions.

VI Partners are Venture Capitalists successfully financing outstanding teams and innovations in the Healthcare and Technology space since 20 years.

Investment focus

Health Care, Biotechnology, Medical Device
Series A, Series B, Series C
Switzerland, Germany, United States

Portfolio highlights

Xeltis — Xeltis is pioneering a restorative approach in cardiovascular therapy.
LeaseTeq — LeaseTeq bietet Privat- sowie Unternehmenskunden das erste komplett digitale Leasingangebot.
Unique — Try Unique Finance GPT to increase productivity by automating manual workload through AI and ChatGPT solutions.

We are an independent Venture Capitalfirm supporting visionary entrepreneurs toreinvent industries through technology.

Investment focus

Software, FinTech, Information Technology
Series A, Seed, Funding Round
Italy, United States, United Kingdom

Portfolio highlights

Exein — Exein provides the most advanced IoT security solution to protect your devices and containers. Protect your IoT devices in real time and at scale.
Avaneidi — Discover Avaneidi's enterprise storage solutions. Designed in Italy with a 'security by design' approach for unparalleled security and reliability.
IdentifAI — IdentifAI pioneers discerning human-AI creations, bolstering authenticity with advanced models. Determine if an image come from AI or from human!

Scientifica Venture Capital offers private equity and venture capital investment services for Italy based startups and firms.

Investment focus

Medical, Biotechnology, Manufacturing
Seed, Private Equity
Italy

Portfolio highlights

Relicta — Relicta solution is a water-soluble bioplastic material obtained from fish processing waste and suitable for packaging solutions.
OhmSpace — OhmSpace provides the satellite market with reliable resistojets.
QuantaBrain — QuantaBrain purpose is to accelerate the diagnosis of psychiatric and neurodevelopmental diseases by applying artificial intelligence.

Elena Paola Lanati

Investment focus

Biotechnology, Manufacturing, Nanotechnology
Seed
Italy

Portfolio highlights

Diamante — Diamante is a company that develops and manufactures autoimmune disease diagnosis devices using nanomaterials. It exploits plants as bioreactors for the sustainable production of nanoparticles based on modified plant viruses that are used in developing new tools. Diamante was founded in 2016 and is headquartered in Verona, Italy.

We enable innovation

Investment focus

Wellness, Health Care, Biotechnology
Corporate Round
Italy

Portfolio highlights

Adamas Biotech — More than a decade of basic research in the field of botanical function-specific antioxidants. The nutraceutical solutions proposed to stem from a patented protected technology.

Spindial Group

Investment focus

Medical, Health Care, Biotechnology
Funding Round
Italy

Portfolio highlights

Glomeria Therapeutics — Glomeria Therapeutics researches, develops, and markets new medical devices for the treatment of serious diseases in the nephrological area. It offers DesmoPD, peritoneal dialysis connection system; SmartPD, an automated management device for peritoneal dialysis solutions to be instilled in peritoneum; and solutions for peritoneal dialysis.Andrea Zanella founded Glomeria Therapeutics in 2010. Its headquarters is in Chieti in Italy.

start-ups, SMEs, technology, co-investment

Investment focus

Biotechnology, Health Care, Information Technology
Pre-Seed, Seed, Funding Round
Germany, The Netherlands, Austria

Portfolio highlights

Filuta AI — Operationalized Composite Artificial Intelligence
Resistell AG — Resistell is a antibiotic resistance test.
iThera Medical — Explore optoacoustic imaging technology for non-invasive in vivo visualization and quantification of disease-related tissue biomarkers.

Utopia is a venture capital firm that is dedicated to life sciences.Utopia SIS is an investment company specializing in healthcare and biomedical research, promoted and owned by the Golinelli Foundation.Utopia was established with the aim of bridging this gap, through investments in high-potential start-ups operating in the Life Sciencessector.

Investment focus

Health Care, Biotechnology, Pharmaceutical
Seed
Italy

Portfolio highlights

CaSRevolution — A novel disease-modifying approach against neurodegeneration

Istituto Nazionale Biostrutture e Biosistemi is a platform for biostructures and biosystems that represent the intersection and the synthesis between the life sciences and physical sciences.

Investment focus

Wellness, Health Care, Biotechnology
Corporate Round
Italy

Portfolio highlights

Adamas Biotech — More than a decade of basic research in the field of botanical function-specific antioxidants. The nutraceutical solutions proposed to stem from a patented protected technology.

a|impact invests in the prevailing form of equity or quasi-equity, focusing our operations mainly on companies.

Investment focus

Medical, Health Care, Biotechnology
Seed
Italy

Portfolio highlights

GenomeUp — GenomeUp is an AI platform (SaaS) to enabling doctors and clinical institutions to diagnose and treat rare genetic diseases in less than 24h. GenomeUp is involved in international research projects and clinical trials in partnership with universities and research centers.

Pi Campus is a startup district and a venture fund that invests in talent. We provide startups with money, mentorship and the best work environment for growth.

Investment focus

Software, Mobile, Biotechnology
Seed, Pre-Seed, Funding Round
Italy, United States, United Kingdom

Portfolio highlights

Loquis — La prima piattaforma per ascoltare e raccontare il mondo tramite podcast geolocalizzati
Fondo — Fondo is an all-in-one accounting platform for startups. We'll handle your bookkeeping, tax, and tax credits so you can focus on building your startup.
Intron Health — Intron is the future of clinical documentation with real-time clinical speech-to-text for 200+ African accents, easing the transition to digitized care.