Top 50 Health Care Angel Investors in Japan (August 2026)

Portfolio highlights

• HANOWA — Hanowa is a matching platform between freelance dental hygienists and dental clinics. It matches dental care workers who want to work in their spare time with dental clinics. It can be used for studying, side jobs, and job change activities.
• Smooth — Smooth is a smart parking service that enables unmanned parking lots.
• Willbox — Willbox is an international logistics company providing an international logistics digital platform for shippers and logistics companies. The company's platform "Giho" connects shippers and logistics companies (transportation, packaging, warehousing, customs clearance, etc.) with a direct contract. It visualizes the three elements of[lead time, money, and safety], which have been regarded as a black box, and supports comparative examination and decision making. Willbox digitizes the packing technique of wooden boxes and steel, mandatory for international logistics, and incorporated them into their system. Their mission is to solve the logistics issues focusing on the large cargo of industrial products.The company was founded in 2019 and is based in Yokohama-shi, Kanagawa.

Portfolio highlights

• Now Do — Now Do provides online growth revolution platform.
• RE — RE specializes in smartphone application design and development.
• Vitalogue Health — Vitalogue Health is a hormone testing service intended to provide access to hormones and medical care. They allow users to self-check the physical condition for pregnancy and how hormones affect it, whether the symptoms are related to menopause, and provide personalized test results, commented on by physicians.

Portfolio highlights

• Onepair — Onepair is a job consulting and recruiting company. Onepair is to co-creating careers by talking about real-world ace with active ace.
• Strainer — Strainer Co., Ltd. is an information distribution platform that conveys corporate information centered on financial data. Although there are not a few media to deliver financial information, the company's strengths are strong to be easily viewed, including financial information of overseas companies.
• LAMILA — LAMILA develops system that improves the creation of retail stores.

Portfolio highlights

• Shiftus — Shiftus is a communication application that can be used in various part-time job sites such as cafes, izakayas, hotels, supermarkets
• Flagellin — Flagellin is a pharmaceutical and medical industry.Development and sales of SaaS that supports sales and marketing of database and analysis services in the pharmaceutical and medical industries
• Giver Take All — Gibber Take All is a Planning, development and management of business sharing platform

Portfolio highlights

• FamiOne — FamiOne is creating a society that will support the future of couples who want to receive children.
• Misaky Tokyo — Marine plant-based, handmade Japanese sweets. These crystal treats are individually handcrafted, the perfect gift idea! Vegan, gluten-free, and additive-free confectionery, with stunning flavors such as Yuzu, Matcha, and Rose. Supporting artisans in their craft. Japanese luxury sweets with a surprise inside.
• Reiwa Travel — Reiwa Travel Company Overview Reiwa Travel is a digital travel agency with the mission to "Design New Travel Experiences." We aim to offer innovative experiences and new societal value in international travel. Since April 2022, we have been offering the international travel booking app 'NEWT'. Our goal is to maximize the digitaltransformation (DX) of booking and management tasks in the travel industry, providing unprecedented “easy, affordable, customizable, and secure” package tours. We are committed to creating social value through the experience of international travel.International Travel Booking App 'NEWT' Service Overview 'NEWT' is an international travel booking app designed to create new travel experiences for new era. It offers an easy booking process, achieves cost-effective pricing, creates customizable trips that meet individual needs, and provides the security that makes travelers feel they made the right choice with NEWT.International Travel Booking App 'NEWT': https://app.adjust.com/iidu9wiWeb version 'NEWT': https://newt.net/

Portfolio highlights

• CUICIN — Quickin is changing the travel experience with the digital transformation.
• HANOWA — Hanowa is a matching platform between freelance dental hygienists and dental clinics. It matches dental care workers who want to work in their spare time with dental clinics. It can be used for studying, side jobs, and job change activities.
• Yondemy — Yondemy is an online platform for children reading books.

Portfolio highlights

• Jizai — Jizai is a provider of artificial intelligence technology, offering AI solutions, software-as-a-service products powered by AI, and robots that utilize AI capabilities for businesses across various industries. The company focuses on generative AI, large language models (LLMs), and robotics, offering customizable AI platforms and automation tools.It also engages in AI consulting and research collaborations.
• Amptalk — Amptalk is a software development firm specializing in operating automatic transcription and analysis of online business negotiations.
• Media Aid — Media Aid is an advertising agency that provides recruitment, marketing, web creation, and SNS management services

Portfolio highlights

• iiba — Iiba is a geospatial platform that specializes in providing location information related to child-rearing.
• Tohakusha — Tohakusha is a creative agency that offers design, production and sale of digital content and EC websites, and content creation services.
• Neighbor — Neighbor is a metaverse game developer that specializes in Fortnite.

Portfolio highlights

• On the Trip — On The Trip is an iOS app that turns your iPhone into an GPS-enabled audio travel guide. It was launched last week and is now available on the iTunes AppStore.
• Amateras Space — Amateras Space is a startup driven by the mission to “expand the realm of human activity,” aiming to establish a next-generation spacesuit business by developing advanced, practical technologies that enable humans to work, explore, and thrive in space and other extreme environments.
• RIMM Sustainability — RIMM Sustainability provides a SaaS platform that enables companies of all sizes to optimise their sustainability management effort. It builds tools for sustainability management, reporting and optimisation.

Portfolio highlights

• 3Sunny — 3Sunny is a company which helps in solve medical care issues so that everyone can feel at ease. The company solves the problems of people in the field while utilizing technology, and create a reliable society that will eventually reach the desired end. 3Sunny was founded in July 2016 and is headquartered in Tokyo, Japan.
• Contrea — MediOS is a cloud-based informed consent (IC) assistance system that assists medical professionals in focusing on essential patient explanations. Many doctors respect explanation time and go out of their way to clarify things so that patients can receive therapy with confidence and peace of mind.
• HerLifeLab — HerLifeLab is healthcare consulting company working for women health and empowerment.

Portfolio highlights

• GPx — GPx is a biotech company that revolutionizes remote chronic disease management with bloodless blood tests. It is dedicated to transforming the standard of care of cardiorenal diseases and enabling patients to better understand their condition, much like the continuous glucose monitor has transformed diabetes care.The company was founded in 2020and is based in Boston, Massachusetts.
• AnotherBall — AnotherBall is a blockchain startup that combines entertainment and blockchain.
• SBX Corporation — AI R&D: Deep learning, Machine learning, Automation, Text mining. Development, customization and maintenance of software platforms for drug discovery and life science research.

Portfolio highlights

• MIL — MIL is a marketing company it can be used for a wide range of video marketing such as video commerce , O2O measures , recruitment videos , and landing videos.
• Vivid Garden — vivid garden is an Agriculture company.
• SAMURAI Security — SAMURAI Security is a best support tech company.

Portfolio highlights

• Dofa — Dofa aims to develop services that enrich the way of life and work of human resources that are active mainly in sales.
• Best Beer Japan — Best Beer Japan provides a barrel tracking software for craft beer and barrel sharing. The company was founded in 2018.
• Vitalogue Health — Vitalogue Health is a hormone testing service intended to provide access to hormones and medical care. They allow users to self-check the physical condition for pregnancy and how hormones affect it, whether the symptoms are related to menopause, and provide personalized test results, commented on by physicians.

Portfolio highlights

• JAPAN HEALTHCARE — Japan Healthcare is a healthcare start-up that works on the prevention of musculoskeletal diseases with environmentally-friendly preventive medicine . Japan Healthcare Build a preventive system for musculoskeletal diseases with environmentally-improving preventive medicine.
• Japan Healthcare Info — Japan Healthcase Info locates english-speaking doctors for you and makes appointments
• Legal Technology Japan — Legal Technology is into development of cloud-based research tool called 'Legal Library' using legal books.

Portfolio highlights

• D-Chain — D-Chain offers services related to IT development and production in the Web3 and Web2 fields.
• Rayout — Rayout is a business consulting company that provides creative content development, recruitment videos, and web production services.
• CAREER BIJIN — Career bijin is a total support company.

Portfolio highlights

• AgeWell Japan — Age Well Japan is a conference and festival aimed at understanding Japan's super-aged society and defining new values for the future. The purpose of the gathering is to bring together young people and the elderly to exchange ideas.
• ONE — One is a Japanese startup. It primarily creates and operates consumer apps, some of which have been sold to publicly traded Japanese corporations.This runs the BeReal exchange application "BeMatch."
• Nicoli — Nicoli is a company that creates content and advertisements that increase happy time for parents and children .

Portfolio highlights

• AgeWell Japan — Age Well Japan is a conference and festival aimed at understanding Japan's super-aged society and defining new values for the future. The purpose of the gathering is to bring together young people and the elderly to exchange ideas.

Portfolio highlights

• SARAH — SARAH has been working on the planning and operation of the gourmet community app "SARAH", which operates a menu gourmet site "SARAH" that allows you to search for items you want to eat from menu-based posts.
• MTU — MTU offers medical security cloud services to medical organizations and delivers IT support, including the recent cyber harm to medical institutions, both online and offline.

Portfolio highlights

• Spine Chronicle — Spine chronicle is a medical device manufacturing firm that specializes in developing orthopedic medical equipment.

Portfolio highlights

• Pleap — Pleap is a medical engineering company specializing in the development of AI and IoT-based technology solutions tailored for medical institutions. The company's product offerings include "medimo" which is an AI tool that automatically creates medical record manuscripts from medical audio.
• AGRI SMILE — AGRI SMILE is a platform that focuses on sharing agricultural technology.
• Conoris Technologies — Conoris Technologies is a staffing agency that offers security check support services for companies.

Portfolio highlights

• Astroscale — Astroscale is one of the few companies in the world proposing to aid in the removal of orbital debris through the provision of End of Life (EOL) and Active Debris Removal (ADR) services. In addition to providing a technical solution, Astroscale is helping to define the business case for this service and are working with national space agencies,international institutions, non-profit organizations, insurance companies and satellite operators to develop norms, regulations and incentives that contribute to the responsible use of space.
• SMS — The corporate website of SMS Co., Ltd. We disclose a wide range of information, including company overview, investor relations, and sustainability.

Portfolio highlights

• Mairu Tech — Mairu tech that enables traveling by private ambulance and welfare taxi more convenient.

Portfolio highlights

• Pleap — Pleap is a medical engineering company specializing in the development of AI and IoT-based technology solutions tailored for medical institutions. The company's product offerings include "medimo" which is an AI tool that automatically creates medical record manuscripts from medical audio.
• Ostance — Ostance is a group that moves the world in all kinds of entertainment.
• Conoris Technologies — Conoris Technologies is a staffing agency that offers security check support services for companies.

Portfolio highlights

• Sorcerer — Sorcerer builds weather balloons that fly for over six months, collecting 1000x more data per dollar and reaching previously inaccessible regions
• Oway — Join thousands that ship freight instantly with Oway's rideshare freight platform and save up to 50% on your shipping. Pickups in just 1 hour, delivered overnight with insurance and tracking included on all shipments.
• Vybe — Vybe is a software company that provides pre-built integrations and AI tools for users to develop and launch internal AI-powered apps.

Portfolio highlights

• Mairu Tech — Mairu tech that enables traveling by private ambulance and welfare taxi more convenient.

Portfolio highlights

• Agatyca — Agatyca is an IT company that develops customized solutions to optimize payment system processes for organizations.

Portfolio highlights

• Neith — Neith is a apparel manufacturer, seller and a whoelseller of water absorbing bralette, lingerie and shorts for women.
• WARC — WARC provides hands-on support for business management departments as well as mergers and acquisition advisory services.
• Vitalogue Health — Vitalogue Health offers Canvas, a home-based hormone testing service for women.

Portfolio highlights

• KURASERU — KURASERU is a Japanese startup company that provides facility matching service for medical social workers and care managers.

Portfolio highlights

• Emol — emol is an application that records emotions and talks with AI robots.emol provide personalized mental and productivity training based on mental data to promote employee well-being and increase employee engagement.

Portfolio highlights

• Zeigo — Zeigo by Schneider Electric provides sustainability software for efficient carbon reduction and supply chain decarbonization, aiming for a carbon-free future.
• RootWave — RootWave is an electronics company that develops tools that kill weeds it enables farmers to control weeds on their farm. Its technology is an alternative substitute for herbicides and other weed control chemicals. The company was founded in 2012 and headquartered in Warwickshire, United Kingdom.
• Sniffer Robotics — Comprehensive methane emissions detection and quantification, advanced imagery and analytics; Sniffer Robotics provides advanced solutions that benefit the environment.

Portfolio highlights

• Elaly — Elaly Technology makes life better for people around the world.We aim to make the value of money and the experience gained from it flatter.As many people as possible will use technology to realize a happier life, independent of the money economy.
• SOELU — SOELU is an online yoga studio where you can take lessons from popular instructors at home for women only. Even if you can't attend yoga classes, the instructor will guide you through the screen, so you can continue online at home!

Portfolio highlights

• Plusmedi — Plusmedi is the developer of MyHospital, a medical care and management app offering personal health record (PHR) solutions. The app aims to help users by reducing the time they spend at the hospital or doctor's office. MyHospital also includes features like bill payment, medication management, and online paperwork.

Portfolio highlights

• Emol — emol is an application that records emotions and talks with AI robots.emol provide personalized mental and productivity training based on mental data to promote employee well-being and increase employee engagement.
• IVA — IVA ensures the safety of the market towards the threat of counterfeit goods.

Portfolio highlights

• SOELU — SOELU is an online yoga studio where you can take lessons from popular instructors at home for women only. Even if you can't attend yoga classes, the instructor will guide you through the screen, so you can continue online at home!

Portfolio highlights

• Villio — Villio provides talent experience SaaS which helps companies with human resource development and recruitment of talented engineers.
• Back Dooor — Back Dooor is an app that provides 1on1 chatting services with favorite player of the users.
• SPeak — SPeak is an IT services firm that operates web content and matching platforms for global talents. It operates JPort Match, which is involved in direct recruiting services. It is a global career platform for budding new talents.

Portfolio highlights

• MI-6 — MI-6 is a research, development, consulting, and project management for material development using IT. We will promote materials informatics in the field of material development with our technological capabilities and a wealth of project knowledge that challenge the world's most advanced technologies .
• ELESTYLE — ELESTYLE are promoting mobile payments and providing high value-added services for users to realize a cashless society.
• Luup — Luup is Japan's #1 e-scooter and e-bike sharing service provider. Luup currently operates in Tokyo, Osaka, Kyoto, and Yokohama, while planning to expand to other cities all over Japan. The service is based on a high-density port network, where anyone can rent and return to their original fleets.

Portfolio highlights

• Quatre — Quatre is a planning, operation and sales of all real promotion platform air catalog.
• KURASERU — KURASERU is a Japanese startup company that provides facility matching service for medical social workers and care managers.

Portfolio highlights

• Ashirase — Ashirase is a developer of a walking navigation system for the visually challenged. The company assists visually impaired people in walking independently. This also allows the user to have more attention to spare for audible warnings in their environment. It includes voice input and guidance via a smartphone app. A vibration interface is attachedto their shoes.

Portfolio highlights

• Newsta — Newsta provides valuable information regarding child-related disabilities, sicknesses, and childcare leave via an in-house consultation app.

Portfolio highlights

• Mairu Tech — Mairu tech that enables traveling by private ambulance and welfare taxi more convenient.

Portfolio highlights

• AgeWell Japan — Age Well Japan is a conference and festival aimed at understanding Japan's super-aged society and defining new values for the future. The purpose of the gathering is to bring together young people and the elderly to exchange ideas.

Portfolio highlights

• FiT — FiT encourages the use of information technology in fitness to address industrial concerns. We will build a highly sustainable fitness facility using a business model that allows consumers to easily use the gym without being burdened by price or procedures, while also allowing owners to build a very successful business with low running costs.
• Aoyama Arts — Aoyama Arts is an architecture and consulting company that develops design offices and supports land search and financing plans.
• Fabric Tokyo — FABRIC TOKYO is a Japanese startup provides a direct-to-consumer custom-made apparel brand. (former-company name Lifestyle Design Co., Ltd.). It enables customers to save their sizes, idea fabrics, and favorite designs, allowing them to make their original clothing later.FABRIC TOKYO was founded in 2012 by Yuichiro Mori and is based in Tokyo,Japan.

Portfolio highlights

• Emol — emol is an application that records emotions and talks with AI robots.emol provide personalized mental and productivity training based on mental data to promote employee well-being and increase employee engagement.
• BoostIO — MAISIN&CO makes meetings efficient. MAISIN&CO was founded in 2014.

Portfolio highlights

• SmarTrial — Activaid owns and operates a social data platform for patients with inflammatory bowel disease. It allows patients to support and exchange information within the patient community with the same disease; provide information necessary for new drug development and matching to clinical trials that suits them; and improve medical treatment. YasuakiHasebe founded Activaid in 2018. It has its headquarters in Tokyo in Japan.
• Genomelink — Genomelink is a platform where people discover more with their DNA data and help businesses build, market and do research with it. The best founders in consumer genomics with real experience in the industry for many years, including M3, Inc. ($13B valued Meditech in Japan), a founding member of the Japanese version of 23andMe, and leadbioinformatician and software engineer at a joint-venture between Illumina and Sony. Raised $4M for Seed Round from Berkeley SkyDeck, SONY, and top-tier Japanese VCs. Supported by Illumina Accelerator, Carlos Bustamante Lab at Stanford University among others.
• MinD in a Device — MinD in a Device Co., Ltd. is a university-launched venture that aims to port human consciousness to devices (machines and computers) in the medium to long term based on long-term research results on consciousness. As the first step toward realization, we will evolve and deepen the "generation model" considered to be the source ofconsciousness, and promote the development of next-generation AI and social implementation.

Portfolio highlights

• Dofa — Dofa aims to develop services that enrich the way of life and work of human resources that are active mainly in sales.
• RIZAP GROUP — RIZAP GROUP is a planning and implementation of medium- and long-term management strategy of the Group, management of business strategy execution support and business activities of Group companies.

Portfolio highlights

• Treinta — Treinta powers 7 million SMBs across the US and Latin America with simple finance, inventory, and sales tools.
• Ferveret — Ferveret develops liquid cooling technology for data centers and other infrastructure. Our company is backed by Y Combinator and MIT Media Lab's E14.
• Kriya AI is now Kalendar AI — Kalendar AI books new revenue on autopilot

Portfolio highlights

• RIZAP — RIZAP is a chain of a private gym that offers fitness training and consulting services.
• Intellect — Intellect is a global mental health benefits company serving 4 million+ members across 100 countries in 120+ languages. Access coaching, therapy, self-care tools, crisis management, L&D programmes, and more.
• Hippo Insurance — Hippo Insurance Services offers a different kind of home insurance, built from the ground up to provide a new standard of care and protection for homeowners. Our goal is to make homes safer and better protected so customers spend less time worrying about the burdens of homeownership and more time enjoying their homes and the life within. Harnessingreal-time data, smart home technology, and a growing suite of home services, we are creating the first integrated home protection platform. Hippo is headquartered in Palo Alto, California with offices in Austin and Dallas, Texas, and insurance products available to more than 80 percent of U.S. homeowners in 37 states. Hippo Insurance Services is a licensed property casualty insurance agent with products underwritten by various insurance companies.

Portfolio highlights

• Elaly — Elaly Technology makes life better for people around the world.We aim to make the value of money and the experience gained from it flatter.As many people as possible will use technology to realize a happier life, independent of the money economy.
• SOELU — SOELU is an online yoga studio where you can take lessons from popular instructors at home for women only. Even if you can't attend yoga classes, the instructor will guide you through the screen, so you can continue online at home!
• DariaMe — DariaMe is a web media planning, development and operation, planning and production of various contents, online consultation service.

Portfolio highlights

• Clear — Clear, Inc. operates sake subscription service “SAKELIFE".
• Cub McPaws — Buy comfortably fashionable kids clothes (4 - 12 years) online in India from Cub Mcpaws at best prices. Gorgeous dresses, jumpsuits, t-shirts, shirts & bottom wear for boys and girls | Free Shipping | COD
• Smartround — Smartround is a specialized finance management platform for startups and their investors. For start-ups, for entrepreneurs who are not familiar with finance, simply enter the necessary information according to the guide, prepare appropriate financing round, and prepare a function that can simulate and execute a capital increase. Support informationsharing and communication with shareholders even after the capital increase.

Portfolio highlights

• HANOWA — Hanowa is a matching platform between freelance dental hygienists and dental clinics. It matches dental care workers who want to work in their spare time with dental clinics. It can be used for studying, side jobs, and job change activities.