Top 50 Health Care Angel Investors in Japan (June 2026)

Portfolio highlights

• M-Box — M-Box provides IT solutions to the pharmaceutical and healthcare industries and operates web services.
• HANOWA — HANAWA is a matching platform between freelance dental hygienists and dental clinics.
• Willbox — Willbox is an international logistics company providing an international logistics digital platform for shippers and logistics companies. The company's platform "Giho" connects shippers and logistics companies (transportation, packaging, warehousing, customs clearance, etc.) with a direct contract. It visualizes the three elements of[lead time, money, and safety], which have been regarded as a black box, and supports comparative examination and decision making. Willbox digitizes the packing technique of wooden boxes and steel, mandatory for international logistics, and incorporated them into their system. Their mission is to solve the logistics issues focusing on the large cargo of industrial products.The company was founded in 2019 and is based in Yokohama-shi, Kanagawa.

Portfolio highlights

• AceRNA Technologies — AceRNA contributes to regenerative medicine and drug discovery through the discovery of novel miRNA functions. It began operation in April 2018, with its headquarters in Kyoto in Japan.
• Epicbase — Epicbase is an AI-based automatic voice transcription service based on voice recognition technology.
• Flagellin — Flagellin is a pharmaceutical and medical industry.Development and sales of SaaS that supports sales and marketing of database and analysis services in the pharmaceutical and medical industries

Portfolio highlights

• GPx — GPx is a biotech company that revolutionizes remote chronic disease management with bloodless blood tests. It is dedicated to transforming the standard of care of cardiorenal diseases and enabling patients to better understand their condition, much like the continuous glucose monitor has transformed diabetes care.The company was founded in 2020and is based in Boston, Massachusetts.
• Epistra — Epistra accelerates research and development in life sciences.
• Activaid — Activaid owns and operates a social data platform for patients with inflammatory bowel disease. It allows patients to support and exchange information within the patient community with the same disease; provide information necessary for new drug development and matching to clinical trials that suits them; and improve medical treatment. YasuakiHasebe founded Activaid in 2018. It has its headquarters in Tokyo in Japan.

Portfolio highlights

• Now Do — Now Do provides online growth revolution platform.
• RE — RE specializes in smartphone application design and development.
• Vitalogue Health — Vitalogue Health offers Canvas, a home-based hormone testing service for women.

Portfolio highlights

• Onepair — Onepair is a job consulting and recruiting company. Onepair is to co-creating careers by talking about real-world ace with active ace.
• Strainer Co., Ltd. — Strainer Co., Ltd. is an information distribution platform that conveys corporate information centered on financial data. Although there are not a few media to deliver financial information, the company's strengths are strong to be easily viewed, including financial information of overseas companies.
• LAMILA — LAMILA develops system that improves the creation of retail stores.

Portfolio highlights

• Cocoach — Cocoach provides online education service.
• Data Viz Lab — Data Viz Lab is a platform that offers data analysis, visualization consulting, and data human resource development support.
• ElevationSpace — ElevationSpace offers high quality & well equipped workspaces giving tenants a nurturing environment .

Portfolio highlights

• JAPAN HEALTHCARE — Japan Healthcare is a healthcare start-up that works on the prevention of musculoskeletal diseases with environmentally-friendly preventive medicine . Japan Healthcare Build a preventive system for musculoskeletal diseases with environmentally-improving preventive medicine.
• Japan Healthcare Info — Japan Healthcase Info locates english-speaking doctors for you and makes appointments
• Legal Technology Japan — Legal Technology is into development of cloud-based research tool called 'Legal Library' using legal books.

Portfolio highlights

• iiba — Iiba is a geospatial platform that specializes in providing location information related to child-rearing.
• Plott — Plott producing youtube animation platform under Vision “Become a Content holder from YouTube”. In August 2019, the company name was changed from Fabo to Plott. Plott, the new company name, is derived from the plot that you make before writing novels, etc., and the idea that “I want to make content all the time” is put in the company name.
• Neighbor — Neighbor is a metaverse game developer that specializes in Fortnite.

Portfolio highlights

• Revorf — Revorf analyzes data and develops AI-related to infectious diseases and healthcare.
• Space Walker — SPACE WALKER specializes in design, manufacture and sale of peripheral components.
• RIMM Sustainability — RIMM Sustainability provides a SaaS platform that enables companies of all sizes to optimise their sustainability management effort. It builds tools for sustainability management, reporting and optimisation.

Portfolio highlights

• Dofa — Dofa aims to develop services that enrich the way of life and work of human resources that are active mainly in sales.
• Best Beer Japan — Best Beer Japan provides a barrel tracking software for craft beer and barrel sharing. The company was founded in 2018.
• Vitalogue Health — Vitalogue Health offers Canvas, a home-based hormone testing service for women.

Portfolio highlights

• MIL — MIL is a marketing company it can be used for a wide range of video marketing such as video commerce , O2O measures , recruitment videos , and landing videos.
• Vivid Garden — vivid garden is an Agriculture company.
• SAMURAI Security —

Portfolio highlights

• CUICIN — Quickin is changing the travel experience with the digital transformation.
• HANOWA — HANAWA is a matching platform between freelance dental hygienists and dental clinics.
• Magic Shields — Magic Shields is a manufacturer and seller of floors, nursing care, and welfare products.

Portfolio highlights

• Manabie — Manabie is an Education Technology start-up company on a mission to provide a new style of online & offline merged learning around the world. We provide students with everything they need for efficient learning; high-quality learning materials, great learning environments, personal coaches and more! We believe that our new method of learning,integrating online and offline will dramatically innovate the way students learn.
• Enechain — enechain provides liquidity in Japan’s energy market by brokering OTC transactions of energy.
• Media Aid — Media Aid is an advertising agency that provides recruitment, marketing, web creation, and SNS management services

Portfolio highlights

• AgeWell Japan — Age Well Japan is a conference and festival aimed at understanding Japan's super-aged society and defining new values for the future. The purpose of the gathering is to bring together young people and the elderly to exchange ideas.
• Towing — Towing is an agricultural company that provides farming, manufacturing, and recycling services.

Portfolio highlights

• Kaimak — Kaymak is a recruitment platform that focuses on creating a recruitment website, planning a recruitment strategy, and managing candidates.
• Recipio — Recipio is an receipt management platform specialized in providing digital receipt solution. Their innovative digital receipt solution and breakthrough receipt-scanning technology.
• Mairu Tech — Mairu tech that enables traveling by private ambulance and welfare taxi more convenient.

Portfolio highlights

• LacuS — LacuS is a food technology company, develops and sells complete nutrition ice cream, provides nutritious food option for people of all ages.

Portfolio highlights

• xCura — xCura alleviating pain and anxiety of people with the help of technology and product therapy VR.

Portfolio highlights

• Spine Chronicle — Spine chronicle is a medical device manufacturing firm that specializes in developing orthopedic medical equipment.

Portfolio highlights

• FiT — FiT encourages the use of information technology in fitness to address industrial concerns. We will build a highly sustainable fitness facility using a business model that allows consumers to easily use the gym without being burdened by price or procedures, while also allowing owners to build a very successful business with low running costs.
• Aoyama Arts — Aoyama Arts is an architecture and consulting company that develops design offices and supports land search and financing plans.
• Fabric Tokyo — FABRIC TOKYO is a Japanese startup provides a direct-to-consumer custom-made apparel brand. (former-company name Lifestyle Design Co., Ltd.). It enables customers to save their sizes, idea fabrics, and favorite designs, allowing them to make their original clothing later.FABRIC TOKYO was founded in 2012 by Yuichiro Mori and is based in Tokyo,Japan.

Portfolio highlights

• Ranimaru — Ranimaru is pet service providing company that offers pet sitting, care of your pet dog in events, professional course about pet sitting.

Portfolio highlights

• Heartseed — Heartseed has set a mission to “open the door to heart disease treatment with regenerative medicine” and is working toward the day-to-day clinical application of myocardial regenerative medicine.
• Matsuri Technologies — matsuri technologies is a real estate tech company that provides solutions to support private property rentals. The company's products include m2m Systems, an Airbnb management platform that helps business operators to manage their accounts, communicate with guests, automate check-ins, offer customer service, and more.

Portfolio highlights

• BionicM — BionicM develops high-performance robot prostheses that enhance mobility for people with disabilities.BionicM has been conducting research on innovative technologies since 2015 at the University of Tokyo's Information Systems Engineering Laboratory (JSK) under the guidance of Professor Inaba and utilizing the world's most advancedrobotics research. In 2016, we were adopted by the Japan Science and Technology Agency as part of "Program for Creating STart-ups from Advanced Research and Technology" (START), and in 2018, the company was established as a joint-stock company.

Portfolio highlights

• BionicM — BionicM develops high-performance robot prostheses that enhance mobility for people with disabilities.BionicM has been conducting research on innovative technologies since 2015 at the University of Tokyo's Information Systems Engineering Laboratory (JSK) under the guidance of Professor Inaba and utilizing the world's most advancedrobotics research. In 2016, we were adopted by the Japan Science and Technology Agency as part of "Program for Creating STart-ups from Advanced Research and Technology" (START), and in 2018, the company was established as a joint-stock company.
• Dots for — Welcome to Dots for Inc.
• Kisui Tech — Kisui Tech is an agricultural AI robotics company that help farmers for farming.

Portfolio highlights

• AgeWell Japan — Age Well Japan is a conference and festival aimed at understanding Japan's super-aged society and defining new values for the future. The purpose of the gathering is to bring together young people and the elderly to exchange ideas.
• ONE — One is a Japanese startup. It primarily creates and operates consumer apps, some of which have been sold to publicly traded Japanese corporations.This runs the BeReal exchange application "BeMatch."
• Nicoli — Nicoli is a company that creates content and advertisements that increase happy time for parents and children .

Portfolio highlights

• Opt Fit — Opt Fit is a fitness industry that provides fitness, wellness and health-care services.
• FiT — FiT encourages the use of information technology in fitness to address industrial concerns. We will build a highly sustainable fitness facility using a business model that allows consumers to easily use the gym without being burdened by price or procedures, while also allowing owners to build a very successful business with low running costs.
• Voxela — Voxels is an AI powered platform on a mission to reinvent caregiving by making incident detection intelligent and actionable.

Portfolio highlights

• AgeWell Japan — Age Well Japan is a conference and festival aimed at understanding Japan's super-aged society and defining new values for the future. The purpose of the gathering is to bring together young people and the elderly to exchange ideas.

Portfolio highlights

• SARAH — SARAH has been working on the planning and operation of the gourmet community app "SARAH", which operates a menu gourmet site "SARAH" that allows you to search for items you want to eat from menu-based posts.
• MTU — MTU offers medical security cloud services to medical organizations and delivers IT support, including the recent cyber harm to medical institutions, both online and offline.

Portfolio highlights

• Spine Chronicle — Spine chronicle is a medical device manufacturing firm that specializes in developing orthopedic medical equipment.

Portfolio highlights

• Pleap — Pleap is a medical engineering company specializing in the development of AI and IoT-based technology solutions tailored for medical institutions. The company's product offerings include "medimo" which is an AI tool that automatically creates medical record manuscripts from medical audio.
• AGRI SMILE — AGRI SMILE is a platform that focuses on sharing agricultural technology.
• Conoris Technologies — Conoris Technologies is a staffing agency that offers security check support services for companies.

Portfolio highlights

• Astroscale — Astroscale is one of the few companies in the world proposing to aid in the removal of orbital debris through the provision of End of Life (EOL) and Active Debris Removal (ADR) services. In addition to providing a technical solution, Astroscale is helping to define the business case for this service and are working with national space agencies,international institutions, non-profit organizations, insurance companies and satellite operators to develop norms, regulations and incentives that contribute to the responsible use of space.
• SMS — The corporate website of SMS Co., Ltd. We disclose a wide range of information, including company overview, investor relations, and sustainability.

Portfolio highlights

• Pleap — Pleap is a medical engineering company specializing in the development of AI and IoT-based technology solutions tailored for medical institutions. The company's product offerings include "medimo" which is an AI tool that automatically creates medical record manuscripts from medical audio.
• Ostance — Ostance is a group that moves the world in all kinds of entertainment.
• Conoris Technologies — Conoris Technologies is a staffing agency that offers security check support services for companies.

Portfolio highlights

• Mairu Tech — Mairu tech that enables traveling by private ambulance and welfare taxi more convenient.

Portfolio highlights

• MIL — MIL is a marketing company it can be used for a wide range of video marketing such as video commerce , O2O measures , recruitment videos , and landing videos.
• Now Do — Now Do provides online growth revolution platform.
• SAURUS JAPAN —

Portfolio highlights

• Mairu Tech — Mairu tech that enables traveling by private ambulance and welfare taxi more convenient.

Portfolio highlights

• Agatyca — Agatyca is an IT company that develops customized solutions to optimize payment system processes for organizations.

Portfolio highlights

• Sorcerer — Sorcerer builds weather balloons that fly for over six months, collecting 1000x more data per dollar and reaching previously inaccessible regions
• Oway — Join thousands that ship freight instantly with Oway's rideshare freight platform and save up to 50% on your shipping. Pickups in just 1 hour, delivered overnight with insurance and tracking included on all shipments.
• Vybe — Vybe is a software company that provides pre-built integrations and AI tools for users to develop and launch internal AI-powered apps.

Portfolio highlights

• Neith — Neith is a apparel manufacturer, seller and a whoelseller of water absorbing bralette, lingerie and shorts for women.
• WARC — WARC provides hands-on support for business management departments as well as mergers and acquisition advisory services.
• Vitalogue Health — Vitalogue Health offers Canvas, a home-based hormone testing service for women.

Portfolio highlights

• Activaid — Activaid owns and operates a social data platform for patients with inflammatory bowel disease. It allows patients to support and exchange information within the patient community with the same disease; provide information necessary for new drug development and matching to clinical trials that suits them; and improve medical treatment. YasuakiHasebe founded Activaid in 2018. It has its headquarters in Tokyo in Japan.
• Genomelink — Genomelink is a platform where people discover more with their DNA data and help businesses build, market and do research with it. The best founders in consumer genomics with real experience in the industry for many years, including M3, Inc. ($13B valued Meditech in Japan), a founding member of the Japanese version of 23andMe, and leadbioinformatician and software engineer at a joint-venture between Illumina and Sony. Raised $4M for Seed Round from Berkeley SkyDeck, SONY, and top-tier Japanese VCs. Supported by Illumina Accelerator, Carlos Bustamante Lab at Stanford University among others.
• MinD in a Device — MinD in a Device Co., Ltd. is a university-launched venture that aims to port human consciousness to devices (machines and computers) in the medium to long term based on long-term research results on consciousness. As the first step toward realization, we will evolve and deepen the "generation model" considered to be the source ofconsciousness, and promote the development of next-generation AI and social implementation.

Portfolio highlights

• emol — emol is an application that records emotions and talks with AI robots.emol provide personalized mental and productivity training based on mental data to promote employee well-being and increase employee engagement.

Portfolio highlights

• Lecto — Lecto provides Saas solutions to eliminate the tedious practices behind financial services
• Luup — Luup is an Internet Company.
• Neighbor — Neighbor is a metaverse game developer that specializes in Fortnite.

Portfolio highlights

• SOELU — SOELU is an online yoga studio where you can take lessons from popular instructors at home for women only. Even if you can't attend yoga classes, the instructor will guide you through the screen, so you can continue online at home!

Portfolio highlights

• Ashirase — Ashirase is a developer of a walking navigation system for the visually challenged. The company assists visually impaired people in walking independently. This also allows the user to have more attention to spare for audible warnings in their environment. It includes voice input and guidance via a smartphone app. A vibration interface is attachedto their shoes.

Portfolio highlights

• Newsta — Newsta provides valuable information regarding child-related disabilities, sicknesses, and childcare leave via an in-house consultation app.

Portfolio highlights

• Mairu Tech — Mairu tech that enables traveling by private ambulance and welfare taxi more convenient.

Portfolio highlights

• AgeWell Japan — Age Well Japan is a conference and festival aimed at understanding Japan's super-aged society and defining new values for the future. The purpose of the gathering is to bring together young people and the elderly to exchange ideas.

Portfolio highlights

• AgeWell Japan — Age Well Japan is a conference and festival aimed at understanding Japan's super-aged society and defining new values for the future. The purpose of the gathering is to bring together young people and the elderly to exchange ideas.

Portfolio highlights

• Favolist5 — Favolist5 is a software company that develops an abbreviated voice SNS based on web3 for personal media.
• Smartround — Smartround is a specialized finance management platform for startups and their investors. For start-ups, for entrepreneurs who are not familiar with finance, simply enter the necessary information according to the guide, prepare appropriate financing round, and prepare a function that can simulate and execute a capital increase. Support informationsharing and communication with shareholders even after the capital increase.
• AnotherBall — AnotherBall is a blockchain startup that combines entertainment and blockchain.

Portfolio highlights

• Cosic — KAREN, operated by ASHBERY, provides 3D interior coordination services according to personal preferences and lifestyle. Features of the service are the simplicity of use and the high quality of KAREN output. This is because users only have to upload photos of their rooms and pick three of their favorite interior photos on KAREN, and they arecommitted to securing the interior coordinator.The company was founded in 2018 and is based in Japan.
• SOELU — SOELU is an online yoga studio where you can take lessons from popular instructors at home for women only. Even if you can't attend yoga classes, the instructor will guide you through the screen, so you can continue online at home!

Portfolio highlights

• KURASERU — KURASERU is a Japanese startup company that provides facility matching service for medical social workers and care managers.

Portfolio highlights

• Zeigo — Zeigo by Schneider Electric provides sustainability software for efficient carbon reduction and supply chain decarbonization, aiming for a carbon-free future.
• RootWave — RootWave is an electronics company that develops tools that kill weeds it enables farmers to control weeds on their farm. Its technology is an alternative substitute for herbicides and other weed control chemicals. The company was founded in 2012 and headquartered in Warwickshire, United Kingdom.
• CoCooking — CoCooking uses food and cooking to create ample opportunity for dialogue and thought, fostering creativity, diversity, and well-being of individuals and communities.