Top 35 Medical Angel Investors in Japan (August 2026)

Portfolio highlights

• Shiftus — Shiftus is a communication application that can be used in various part-time job sites such as cafes, izakayas, hotels, supermarkets
• Flagellin — Flagellin is a pharmaceutical and medical industry.Development and sales of SaaS that supports sales and marketing of database and analysis services in the pharmaceutical and medical industries
• Giver Take All — Gibber Take All is a Planning, development and management of business sharing platform

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• IWG — IWG is a medical start-up that provides cloud-based solutions for medical resource shortages and work support tools.

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• Spectee — Spectee is a online news agency that specializes in curating and publishing real-time social media UGC video. By using artificial intelligence patented by Spectee, It is able to reduce the time taken to analyze and sort social media news content, giving you faster access to the very latest UGC video. Expect video covering both Japanese andworldwide news from accidents and disasters to lifestyle and entertainment.​ it newsroom is verifying and acquiring licenses of those contents for broadcasters and publishers.
• AutoPhagyGO — AutoPhagyGO offers autophagy solutions for the prevention and treatment of neurodegenerative diseases. Autophagy, the primary mechanism that controls lifespan, is controlled by its numerous aging-related occurrences and diseases may be preventable and treatable. The company uses the findings of the most recent autophagy research to promote healthylongevity.
• Synspective — Synspective provides one-stop-solutions by satellite gathered geospatial data. The core technology was developed by the ImPACT program led by The Cabinet Office, Government of Japan, building small SAR satellites and constellations, allowing frequent observation of areas of interest (AOI). Synspective uses its satellites to produce SAR data which can be provided to both government and commercial clients as-is, as well as transform that data through AI solutions to produce insights and user-friendly information across industries.

Portfolio highlights

• MedPeer — MedPeer operates as a community site for doctors. MedPeer is a recruitment agency collective registration service.MedPeer operation of "MedPeer," a collective intelligence service/ community website for physicians.
• Rehasaku — Rehasaku is a service that uses technology to support both medical professionals, such as physiotherapists and judo rehabilitation practitioners, and patients.

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• Mairu Tech — Mairu tech that enables traveling by private ambulance and welfare taxi more convenient.

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• CUICIN — Quickin is changing the travel experience with the digital transformation.
• HANOWA — Hanowa is a matching platform between freelance dental hygienists and dental clinics. It matches dental care workers who want to work in their spare time with dental clinics. It can be used for studying, side jobs, and job change activities.
• Yondemy — Yondemy is an online platform for children reading books.

Portfolio highlights

• Heartseed — Heartseed is a biotechnology research firm that specializes in the development of purified ventricular cardiomyocytes derived from induced pluripotent stem cells for the treatment of heart failure. The company employs an innovative methodology that involves the creation of cardiomyocyte spheroids, small clusters of heart cells, using stem cells.These spheroids are then surgically implanted into the heart to improve its performance.
• Matsuri Technologies — matsuri technologies is a real estate tech company that provides solutions to support private property rentals. The company's products include m2m Systems, an Airbnb management platform that helps business operators to manage their accounts, communicate with guests, automate check-ins, offer customer service, and more.

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• Dofa — Dofa aims to develop services that enrich the way of life and work of human resources that are active mainly in sales.
• Best Beer Japan — Best Beer Japan provides a barrel tracking software for craft beer and barrel sharing. The company was founded in 2018.
• Vitalogue Health — Vitalogue Health is a hormone testing service intended to provide access to hormones and medical care. They allow users to self-check the physical condition for pregnancy and how hormones affect it, whether the symptoms are related to menopause, and provide personalized test results, commented on by physicians.

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• KURASERU — KURASERU is a Japanese startup company that provides facility matching service for medical social workers and care managers.

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• Mairu Tech — Mairu tech that enables traveling by private ambulance and welfare taxi more convenient.

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• Flyle — Flyle provides a cloud based platform for product management helping customers to improve productivity & creativity in product development.
• Reiwa Travel — Reiwa Travel Company Overview Reiwa Travel is a digital travel agency with the mission to "Design New Travel Experiences." We aim to offer innovative experiences and new societal value in international travel. Since April 2022, we have been offering the international travel booking app 'NEWT'. Our goal is to maximize the digitaltransformation (DX) of booking and management tasks in the travel industry, providing unprecedented “easy, affordable, customizable, and secure” package tours. We are committed to creating social value through the experience of international travel.International Travel Booking App 'NEWT' Service Overview 'NEWT' is an international travel booking app designed to create new travel experiences for new era. It offers an easy booking process, achieves cost-effective pricing, creates customizable trips that meet individual needs, and provides the security that makes travelers feel they made the right choice with NEWT.International Travel Booking App 'NEWT': https://app.adjust.com/iidu9wiWeb version 'NEWT': https://newt.net/
• Linkage — Linkage is a Online health support business and Online specific health guidance.

Portfolio highlights

• Clear — Clear, Inc. operates sake subscription service “SAKELIFE".
• Cub McPaws — Buy comfortably fashionable kids clothes (4 - 12 years) online in India from Cub Mcpaws at best prices. Gorgeous dresses, jumpsuits, t-shirts, shirts & bottom wear for boys and girls | Free Shipping | COD
• Smartround — Smartround is a specialized finance management platform for startups and their investors. For start-ups, for entrepreneurs who are not familiar with finance, simply enter the necessary information according to the guide, prepare appropriate financing round, and prepare a function that can simulate and execute a capital increase. Support informationsharing and communication with shareholders even after the capital increase.

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• Ashirase — Ashirase is a developer of a walking navigation system for the visually challenged. The company assists visually impaired people in walking independently. This also allows the user to have more attention to spare for audible warnings in their environment. It includes voice input and guidance via a smartphone app. A vibration interface is attachedto their shoes.

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• Neith — Neith is a apparel manufacturer, seller and a whoelseller of water absorbing bralette, lingerie and shorts for women.
• WARC — WARC provides hands-on support for business management departments as well as mergers and acquisition advisory services.
• Vitalogue Health — Vitalogue Health is a hormone testing service intended to provide access to hormones and medical care. They allow users to self-check the physical condition for pregnancy and how hormones affect it, whether the symptoms are related to menopause, and provide personalized test results, commented on by physicians.

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• Jinba — Helping regulated enterprises build and ship production-level AI agents as fast as startups.
• Didit — Website: https://didit.me/ Whitepaper: https://whitepaper.didit.me/ Technical docs: https://docs.didit.me/ Didit App: https://didit.me/download Business console: https://business.didit.me How can we offer free KYC:https://didit.me/blog/how-we-are-able-to-provide-free-kyc-forever Didit vs Worldcoin: https://didit.me/blog/didit-vs-worldcoin
• Wayco — Wayco offers AI software that automates client intake and case workflows for law firms using voice and referral intelligence processing.

Portfolio highlights

• 3Sunny — 3Sunny is a company which helps in solve medical care issues so that everyone can feel at ease. The company solves the problems of people in the field while utilizing technology, and create a reliable society that will eventually reach the desired end. 3Sunny was founded in July 2016 and is headquartered in Tokyo, Japan.
• Contrea — MediOS is a cloud-based informed consent (IC) assistance system that assists medical professionals in focusing on essential patient explanations. Many doctors respect explanation time and go out of their way to clarify things so that patients can receive therapy with confidence and peace of mind.
• HerLifeLab — HerLifeLab is healthcare consulting company working for women health and empowerment.

Portfolio highlights

• HANOWA — Hanowa is a matching platform between freelance dental hygienists and dental clinics. It matches dental care workers who want to work in their spare time with dental clinics. It can be used for studying, side jobs, and job change activities.
• Smooth — Smooth is a smart parking service that enables unmanned parking lots.
• Willbox — Willbox is an international logistics company providing an international logistics digital platform for shippers and logistics companies. The company's platform "Giho" connects shippers and logistics companies (transportation, packaging, warehousing, customs clearance, etc.) with a direct contract. It visualizes the three elements of[lead time, money, and safety], which have been regarded as a black box, and supports comparative examination and decision making. Willbox digitizes the packing technique of wooden boxes and steel, mandatory for international logistics, and incorporated them into their system. Their mission is to solve the logistics issues focusing on the large cargo of industrial products.The company was founded in 2019 and is based in Yokohama-shi, Kanagawa.

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• Pleap — Pleap is a medical engineering company specializing in the development of AI and IoT-based technology solutions tailored for medical institutions. The company's product offerings include "medimo" which is an AI tool that automatically creates medical record manuscripts from medical audio.
• Ostance — Ostance is a group that moves the world in all kinds of entertainment.
• Conoris Technologies — Conoris Technologies is a staffing agency that offers security check support services for companies.

Portfolio highlights

• Plusmedi — Plusmedi is the developer of MyHospital, a medical care and management app offering personal health record (PHR) solutions. The app aims to help users by reducing the time they spend at the hospital or doctor's office. MyHospital also includes features like bill payment, medication management, and online paperwork.

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• ookami — Ookami provides Player, a sport media application. It is a startup that creates new value of sports by harmonizing individuals and IT technology. The company offers technology solutions, with a particular focus in financial services software, application and communication software, software as a service, and online social networking services.
• Mign — Mign offers a generative AI-related SaaS solutions for the construction and real estate fields.
• CAREER BIJIN — Career bijin is a total support company.

Portfolio highlights

• Pleap — Pleap is a medical engineering company specializing in the development of AI and IoT-based technology solutions tailored for medical institutions. The company's product offerings include "medimo" which is an AI tool that automatically creates medical record manuscripts from medical audio.
• Terrafarm — Terrafarm is a Tokyo-based agritech and aerospace start-up that develops fully automated, space-ready plant factory modules designed to operate in extreme environments.
• Conoris Technologies — Conoris Technologies is a staffing agency that offers security check support services for companies.

Portfolio highlights

• Quatre — Quatre is a planning, operation and sales of all real promotion platform air catalog.
• KURASERU — KURASERU is a Japanese startup company that provides facility matching service for medical social workers and care managers.

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• Neith — Neith is a apparel manufacturer, seller and a whoelseller of water absorbing bralette, lingerie and shorts for women.
• WARC — WARC provides hands-on support for business management departments as well as mergers and acquisition advisory services.
• Vitalogue Health — Vitalogue Health is a hormone testing service intended to provide access to hormones and medical care. They allow users to self-check the physical condition for pregnancy and how hormones affect it, whether the symptoms are related to menopause, and provide personalized test results, commented on by physicians.

Portfolio highlights

• SARAH — SARAH has been working on the planning and operation of the gourmet community app "SARAH", which operates a menu gourmet site "SARAH" that allows you to search for items you want to eat from menu-based posts.
• MTU — MTU offers medical security cloud services to medical organizations and delivers IT support, including the recent cyber harm to medical institutions, both online and offline.

Portfolio highlights

• SmarTrial — Activaid owns and operates a social data platform for patients with inflammatory bowel disease. It allows patients to support and exchange information within the patient community with the same disease; provide information necessary for new drug development and matching to clinical trials that suits them; and improve medical treatment. YasuakiHasebe founded Activaid in 2018. It has its headquarters in Tokyo in Japan.
• Genomelink — Genomelink is a platform where people discover more with their DNA data and help businesses build, market and do research with it. The best founders in consumer genomics with real experience in the industry for many years, including M3, Inc. ($13B valued Meditech in Japan), a founding member of the Japanese version of 23andMe, and leadbioinformatician and software engineer at a joint-venture between Illumina and Sony. Raised $4M for Seed Round from Berkeley SkyDeck, SONY, and top-tier Japanese VCs. Supported by Illumina Accelerator, Carlos Bustamante Lab at Stanford University among others.
• MinD in a Device — MinD in a Device Co., Ltd. is a university-launched venture that aims to port human consciousness to devices (machines and computers) in the medium to long term based on long-term research results on consciousness. As the first step toward realization, we will evolve and deepen the "generation model" considered to be the source ofconsciousness, and promote the development of next-generation AI and social implementation.

Portfolio highlights

• Kaimak — Kaymak is a recruitment platform that focuses on creating a recruitment website, planning a recruitment strategy, and managing candidates.
• Nose ID — Nose ID is a mobile application designed to monitor and protect pet dogs in the vicinity.
• Mairu Tech — Mairu tech that enables traveling by private ambulance and welfare taxi more convenient.

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• Agatyca — Agatyca is an IT company that develops customized solutions to optimize payment system processes for organizations.

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• Next Innovation — Next Innovation is an online consulting provider for health care.
• Next Innovation — Next Innovation is an investment firm that focuses on the education sector.

Portfolio highlights

• MedPeer — MedPeer operates as a community site for doctors. MedPeer is a recruitment agency collective registration service.MedPeer operation of "MedPeer," a collective intelligence service/ community website for physicians.

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• Mairu Tech — Mairu tech that enables traveling by private ambulance and welfare taxi more convenient.

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• Aiwell — Aiwell is a medical and health company that provides health information and the provision of health promotion and prevention services.

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• Now Do — Now Do provides online growth revolution platform.
• RE — RE specializes in smartphone application design and development.
• Vitalogue Health — Vitalogue Health is a hormone testing service intended to provide access to hormones and medical care. They allow users to self-check the physical condition for pregnancy and how hormones affect it, whether the symptoms are related to menopause, and provide personalized test results, commented on by physicians.

Portfolio highlights

• Helpfeel — Our vision is to make saving, sharing, and exploring ideas as natural as breathing. On this journey we're humbled to be helping millions around the world from solo makers to university research labs, from gamers to pro designers, and large to small teams like ours.
• HACARUS — We make AI work, where common Big Data aproaches fail. Get explainable results, even from small data amounts. Available on the cloud or as embedded devices.

Portfolio highlights

• Mederi — Mederi keeps creating services that encourage mental and physical harmony while pursuing safety and peace of mind. The company offers a social safety net that fully supports female employees' health concerns.
• StoryHub — StoryHub is a powerful all-in-one AI editing assistant designed to help users create high-quality content quickly, efficiently, and at a significantly lower cost. Whether you're drafting blog posts, polishing articles, scripting videos, or refining marketing copy, StoryHub streamlines the entire content creation process with intelligent tools

Portfolio highlights

• GPx — GPx is a biotech company that revolutionizes remote chronic disease management with bloodless blood tests. It is dedicated to transforming the standard of care of cardiorenal diseases and enabling patients to better understand their condition, much like the continuous glucose monitor has transformed diabetes care.The company was founded in 2020and is based in Boston, Massachusetts.
• AnotherBall — AnotherBall is a blockchain startup that combines entertainment and blockchain.
• SBX Corporation — AI R&D: Deep learning, Machine learning, Automation, Text mining. Development, customization and maintenance of software platforms for drug discovery and life science research.