Top 15 Biotechnology Angel Investors in Japan (August 2026)

Portfolio highlights

• Mobcast Group — mobcast is a sports entertainment company that operates a mobile entertainment platform for smartphones and feature phones. It supports customers with social game and social media services. The company was founded in 2009 and is based in Tokyo, Japan. Currently, it operates as a subsidiary of mobcast Inc.
• SmartApp Japan — Smart Apps is a developer of a blockchain services application designed for smartphones. The company's application uses cryptocurrency technology to offer token issuance, initial coin offering and dApps design support, providing a launchpad for start-up blockchain-related businesses.

Portfolio highlights

• AlgaleX — AlgaleX is a food technology and biotechnology company that develops AI-powered algae fermentation technology to produce sustainable food ingredients, nutritional compounds, and bioproducts. The company leverages proprietary AI-driven cultivation and fermentation systems to convert underutilized food byproducts into high-value microalgae rich innutrients such as DHA, umami compounds, and other functional ingredients. Its mission is to build a circular bioeconomy by reducing food waste while providing sustainable alternatives to marine- and animal-derived ingredients.The company's core technology is Touji-24, an AI-powered algae cultivation and fermentation control system that automates and optimizes microalgae production. Using proprietary fermentation processes and food byproducts such as awamori lees, AlgaleX cultivates algae that can be used to produce Umamo, a plant-based ingredient combining seafood-like umami flavor with high concentrations of DHA. This approach reduces reliance on wild-caught fish as a source of omega-3 fatty acids while upcycling food industry byproducts into valuable nutritional ingredients.

Portfolio highlights

• MoonJapan — MoonJapan is an educational impact startup that offers a variety of programs and thorough assistance.
• Memory Lab — Memory Lab is a research laboratory that offers AI paper analysis and development solutions.
• ElevationSpace — ElevationSpace offers high quality & well equipped workspaces giving tenants a nurturing environment .

Portfolio highlights

• Monoun — Mono.un provides users with opportunities to meet authors and collaborate on tales and specializes in bringing exciting experiences full of stories of Japanese culture to the world.
• Memory Lab — Memory Lab is a research laboratory that offers AI paper analysis and development solutions.

Portfolio highlights

• AlgaleX — AlgaleX is a food technology and biotechnology company that develops AI-powered algae fermentation technology to produce sustainable food ingredients, nutritional compounds, and bioproducts. The company leverages proprietary AI-driven cultivation and fermentation systems to convert underutilized food byproducts into high-value microalgae rich innutrients such as DHA, umami compounds, and other functional ingredients. Its mission is to build a circular bioeconomy by reducing food waste while providing sustainable alternatives to marine- and animal-derived ingredients.The company's core technology is Touji-24, an AI-powered algae cultivation and fermentation control system that automates and optimizes microalgae production. Using proprietary fermentation processes and food byproducts such as awamori lees, AlgaleX cultivates algae that can be used to produce Umamo, a plant-based ingredient combining seafood-like umami flavor with high concentrations of DHA. This approach reduces reliance on wild-caught fish as a source of omega-3 fatty acids while upcycling food industry byproducts into valuable nutritional ingredients.

Portfolio highlights

• Morus — Morus is a university-based biotech startup developing functional food ingredients from silkworms to address global health and nutrition challenges.
• Epicbase — Epicbase is an AI-based automatic voice transcription service based on voice recognition technology.
• Somewhere — Somewhere is engaged in the travel and transportation business.

Portfolio highlights

• GPx — GPx is a biotech company that revolutionizes remote chronic disease management with bloodless blood tests. It is dedicated to transforming the standard of care of cardiorenal diseases and enabling patients to better understand their condition, much like the continuous glucose monitor has transformed diabetes care.The company was founded in 2020and is based in Boston, Massachusetts.
• AnotherBall — AnotherBall is a blockchain startup that combines entertainment and blockchain.
• SBX Corporation — AI R&D: Deep learning, Machine learning, Automation, Text mining. Development, customization and maintenance of software platforms for drug discovery and life science research.

Portfolio highlights

• Shiftus — Shiftus is a communication application that can be used in various part-time job sites such as cafes, izakayas, hotels, supermarkets
• Flagellin — Flagellin is a pharmaceutical and medical industry.Development and sales of SaaS that supports sales and marketing of database and analysis services in the pharmaceutical and medical industries
• Giver Take All — Gibber Take All is a Planning, development and management of business sharing platform

Portfolio highlights

• Helpfeel — Our vision is to make saving, sharing, and exploring ideas as natural as breathing. On this journey we're humbled to be helping millions around the world from solo makers to university research labs, from gamers to pro designers, and large to small teams like ours.
• HACARUS — We make AI work, where common Big Data aproaches fail. Get explainable results, even from small data amounts. Available on the cloud or as embedded devices.

Portfolio highlights

• Jizai — Jizai is a provider of artificial intelligence technology, offering AI solutions, software-as-a-service products powered by AI, and robots that utilize AI capabilities for businesses across various industries. The company focuses on generative AI, large language models (LLMs), and robotics, offering customizable AI platforms and automation tools.It also engages in AI consulting and research collaborations.
• MemoriaPet — Memoria Pet operated by Next Paradigm 2 Co., Ltd. Creates full-color 3D-printed pet figurines from a single uploaded photo. Uses AI to generate 3D models, followed by full-color 3D printing.
• Tsunagari AI — Tsunagari specializes in developing and providing AI-powered consultation services tailored for local governments, aiming to enhance administrative efficiency, support citizen engagement, and streamline public service delivery.

Portfolio highlights

• SmarTrial — Activaid owns and operates a social data platform for patients with inflammatory bowel disease. It allows patients to support and exchange information within the patient community with the same disease; provide information necessary for new drug development and matching to clinical trials that suits them; and improve medical treatment. YasuakiHasebe founded Activaid in 2018. It has its headquarters in Tokyo in Japan.
• Genomelink — Genomelink is a platform where people discover more with their DNA data and help businesses build, market and do research with it. The best founders in consumer genomics with real experience in the industry for many years, including M3, Inc. ($13B valued Meditech in Japan), a founding member of the Japanese version of 23andMe, and leadbioinformatician and software engineer at a joint-venture between Illumina and Sony. Raised $4M for Seed Round from Berkeley SkyDeck, SONY, and top-tier Japanese VCs. Supported by Illumina Accelerator, Carlos Bustamante Lab at Stanford University among others.
• MinD in a Device — MinD in a Device Co., Ltd. is a university-launched venture that aims to port human consciousness to devices (machines and computers) in the medium to long term based on long-term research results on consciousness. As the first step toward realization, we will evolve and deepen the "generation model" considered to be the source ofconsciousness, and promote the development of next-generation AI and social implementation.

Portfolio highlights

• digzyme — Digzyme develops new enzymatic processes using bioinformatics. The company automates various stages of analysis related to the development of enzymes and bioprocesses using their core bioinformatics technology and further optimize using accumulated data.
• Varinos — Varinos is a clinical laboratory contract analysis company that is a partner of medical institutions. Varinos provides genomic testing development and contract analysis services using the latest technology, the next-generation sequencer.
• Metagen Therapeutics — Metagen Therapeutics (MGTx) is a clinical-stage company operating Japan’s first GMP-compliant manufacturing platform for fecal microbiota transplantation (FMT) therapies. The company combines proprietary paired metagenomic datasets with AI/ML-driven donor-recipient matching to advance precision microbiome medicine across ulcerative colitis,immuno-oncology, and neurodegenerative disease. Headquartered in Tsuruoka, Japan, MGTx leverages a cross-border regulatory strategy spanning PMDA and FDA pathways, positioning it as a platform bridging Japanese clinical innovation with global market access.

Portfolio highlights

• Logomix — Logomix Inc is a mammalian cellular genome architect startup. Logomix proprietary platform, Geno-Writing™, technology integrates large-scale (Mb) human genome-writing technologies and providing genetically architected versatile human cells and/or downsized cells and microbes for drug development and cell & gene therapy area.Majority ofthe cell engineering companies are currently focused on optimization of gene clusters by automatic high throughput system however, Logomix’s Geno-Writing™ provides the required tools for dealing with mammalian or complex genomes. Logomix works with partners by providing new biology-based solutions to co-create business and social values on Geno-Writing™ platform Current Focus Area includes: 1. Human Health & Therapeutics 2. Biomaterials & Chemicals 3. Agriculture & EnvironmentLogomix has 11 ongoing collaborative research partnerships. Currently Logomix is specifically looking for industry partners to address unmet needs in neurodegenerative disease areas.

Portfolio highlights

• Heartseed — Heartseed is a biotechnology research firm that specializes in the development of purified ventricular cardiomyocytes derived from induced pluripotent stem cells for the treatment of heart failure. The company employs an innovative methodology that involves the creation of cardiomyocyte spheroids, small clusters of heart cells, using stem cells.These spheroids are then surgically implanted into the heart to improve its performance.
• Matsuri Technologies — matsuri technologies is a real estate tech company that provides solutions to support private property rentals. The company's products include m2m Systems, an Airbnb management platform that helps business operators to manage their accounts, communicate with guests, automate check-ins, offer customer service, and more.

Portfolio highlights

• D-Chain — D-Chain offers services related to IT development and production in the Web3 and Web2 fields.
• Rayout — Rayout is a business consulting company that provides creative content development, recruitment videos, and web production services.
• CAREER BIJIN — Career bijin is a total support company.