Top 50 Medical Device VC (Venture Capital) Funds in United States in November 2024

Investor	Medical Device United States investments
Innova Memphis	71
SOSV	20
Portfolia	19
Broadview Ventures	19
HealthTech Capital	18
CincyTech	18
MB Venture Partners	16
Good Growth Capital	16
North Coast Ventures	16
Texas HALO Fund	15
Maine Angels	15
Oxford Finance LLC	15
Boston Harbor Angels	15
Arboretum Ventures	15
TEDCO	15
Connecticut Innovations	14
Wavemaker 360	14
Ben Franklin Technology Partners of Southeastern Pennsylvania	13
Khosla Ventures	13
Horizon Technology Finance	13
Versant Ventures	13
U.S. Venture Partners	13
Oxford Bioscience Partners	13
New Enterprise Associates	13
Houston Angel Network	12
Catalyst Health Ventures	12
Wisconsin Investment Partners	12
Canaan Partners	12
Catalyst Health Ventures	12
Delphi Ventures	12
Sand Hill Angels	12
Split Rock Partners	11
Kleiner Perkins	11
St. Louis Arch Angels	11
Gaingels	11
Life Science Angels	11
Tech Coast Angels	11
Three Arch Partners	10
Keiretsu Capital	10
Asset Management Ventures (AMV)	10
Silicon Valley Bank	10
The Vertical Group	10
Virginia Venture Partners	10
Morgenthaler Ventures	10
DeNovo Ventures	10
Rev1 Ventures	10
Keiretsu Forum	10
Shangbay Capital	10
Sante Ventures	10
Third Rock Ventures	10

Founded in 2007 by the Memphis Bioworks Foundation, Innova is a pre-seed, seed and early-stage investor focused on starting and funding high-growth companies in the Biosciences, Technology and AgBio fields across the state of Tennessee. Innova links capital with great ideas to create groundbreaking products and services.At Innova we invest instart-up companies, help them grow, and then assist them in linking with established corporations for licensing, buy-outs or further investments. We provide the synergy of experienced management, market expertise and venture capital to accelerate the development of new products and services into viable business units that can stand on their own and then take their place with a mature market leader, if desired.Whether an innovation is still on the drawing board or stalled in the market place the Innova staff has the expertise, skills, and experience to envision and create a functioning business unit that is prepared to thrive in the market place. Technical know-how, market-proven staffing, and "just-right" funding assure the greatest chance possible for success.

Investment focus

Health Care, Medical, Medical Device
Seed, Pre-Seed, Convertible Note
United States, Argentina, United Kingdom

Portfolio highlights

Rantizo — Fly more acres, deliver better service. The equipment, tools, and expertise you need to be the grower's first call for drone spray services.
iYOTAH Solutions — Take your dairy operation to the next level. Our state of the art platform helps you save time, increase efficiencies and profits and unlock new opportunities.
Glanris — Glanris developed a completely green, non-toxic, filtration media for water purification from an agriculture by-product. This agricultural product is grown around the world, is plentiful, and can be used locally to ensure clean drinking water in developing countries. It also gives local farmers a significant additional income source for a productthat today they are throwing away.This media has been independently tested over the last two years of development and is ready for production.

SOSV is a global, deep tech venture capital firm that operates the HAX and IndieBio startup development programs focused on human and planetary health. SOSV invests $500,000 in startups at their inception as they onboard either HAX or IndieBio for a 4-6 month period designed to accelerate the raise of their next institutional round. SOSV joins thelater rounds of HAX and IndieBio graduates. HAX, based in a 35,000 sq ft facility in Newark, NJ, is equipped with machine tools, 3D printers, chemical, electrical and mechanical engineering labs, as well as on-staff engineering and design experts. SOSV's IndieBio has locations in NYC and San Francisco, both of which offer extensive services and facilities to founders including on-site BSL-2 labs, well equipped lab benches and hoods, and advanced lab equipment, such as chromatography equipment.

Investment focus

Biotechnology, Health Care, Software
Seed, Convertible Note, Pre-Seed
United States, India, United Kingdom

Portfolio highlights

MixRift — MIXRIFT - game developers specialized in Mixed Reality
unspun — From 3D scan to perfect fitting custom jeans. unspun makes each pair of jeans unique to your actual body and design. On a mission to reduce global carbon emissions by 1%. As seen in Fast Company's World Changing Ideas, Time's Best Inventions, and PopSci's Best of What's New. Welcome to the future of apparel.
Mesa Quantum — Unlock the potential of chip-scale quantum sensing for enhanced Position, Navigation, And Timing capabilities. Explore Mesa Quantum's practical solutions.

Investing Funds Designed for Women Backing Innovative Companies We Want in the World - For Returns and Impact

Investment focus

Health Care, Software, Biotechnology
Seed, Series A, Series B
United States, Canada, Argentina

Portfolio highlights

Attn: Grace — Attn: Grace is a sustainable wellness brand designed for women. Starting with bladder leakage, they're creating thoughtful, more sustainable solutions for life’s inconvenient truths, one challenge at a time.
Harvest Thermal — We are manufacturers of the cleanest home energy solution on the market today. We offer a cloud-enabled, ultra-clean heating, cooling and hot water system for residential customers. The brains of the system is our award-winning Harvest Pod that slashes carbon emissions, saves on utility bills, and
Zero Point Five Therapeutics — A drug development company treating soil transmitted helminthiasis (STH) through the FDA as a single dose formulation. STH is a disease impacting poor rural communities of color with poor sewage systems.

Broadview Ventures, Inc. (Broadview) was established in 2008 as a new program conceived by the Leducq family. Through Broadview, the trust will work to accelerate the development of promising technology in cardiovascular and neurovascular disease through targeted investment in and support of early stage technology ventures.The FoundationLeducq, based in Paris, France, is the beneficiary of a charitable trust. In order to further the Foundation Leducq's mission in cardiovascular and neurovascular disease, the trust has made funds available to Broadview to develop a program which will promote early state technology in these fields through investments, licensing agreements and consortium funding arrangements, as well as professional, management and consulting support.With this initiative the trust joins other leaders in the venture philanthropy movement in seeking creative solutions to the problem of what is commonly referred to as the 'translational gap', a significant component of which is a lack of funding at a critical moment in the development of new technology and science.

Investment focus

Health Care, Biotechnology, Medical Device
Series A, Seed, Debt Financing
United States, Canada, Israel

Portfolio highlights

IsomAb — IsomAb evaluate and develop isoform specific antibodies to treat disease.
CroíValve — CroíValve is a developed a safe, effective, easy to use, percutaneous solution for treating all patients with severe Tricuspid Regurgitation
CorFlow Therapeutics AG — CorFlow Therapeutics is a medtech startup that develops proprietary technologies for diagnosis and treatment of microvascular obstructions in heart attack patients. The CorFlow technologies enable interventional cardiologists to diagnose and treat MVO in severe heart attack patients thereby potentially reducing the short- and long-term complicationrates in these patients.

Private angel investors and corporate venture ecosystem investing in healthtech, digital health and other healthcare technologies startups

Investment focus

Health Care, Medical Device, Medical
Seed, Series A, Convertible Note
United States

Portfolio highlights

SafKan Health — OtoSet® by SafKan Health is the first FDA Cleared automated ear cleaning device for the 35 million Americans affected by impacted earwax - the leading cause of conductive hearing loss.
GT Metabolic Solutions — GT Metabolic Solutions has developed minimally-invasive incisionless bypass technology for bariatric, metabolic and digestive surgery.
Wavely Diagnostics — Wavely Diagnostics is pioneering the future of remote digital diagnostics and enabling telehealth growth by leveraging smartphone technology to address pediatric care.

CincyTech is one of the Midwest's most active seed funds, investing in disruptive human health and technology companies in Ohio.

Investment focus

Software, Health Care, Biotechnology
Seed, Series A, Series B
United States

Portfolio highlights

Amify — We help brands selling on Amazon maximize sales and profitability by providing complete strategy, management and operational services.
Invirsa — Invirsa is developing a unique, broad platform based on a naturally occurring small molecule (INV-102) that has demonstrated enhanced immune response to infection. INV-102 not only reduces viral infection, and potentially bacterial replication, it also reduces inflammation, while enhancing the bodies wound healing response. Invirsa'stechnology is first being developed in the ophthalmology and pulmonary space.Invirsa’s technology has the potential to be a first line therapy for common infectious diseases, whether it's the 100 million viral pulmonary infections or the 5 million infectious conjunctivitis cases that occur every year in the US alone.
Voxel — Voxel utilizes advanced mathematics and artificial intelligence to rapidly generate functionally graded meta-materials for high performance applications through additive manufacturing. We provides performance leaps in the defence, automotive, aerospace, medical, industrial, and other demanding areas and unlock new capabilities for our customers.

MB Venture Partners in Memphis, TN provides venture capital for life sciences: medical device, biotechnology companies, products for musculoskeletal diseases

Investment focus

Health Care, Medical, Medical Device
Seed, Series B, Series C
United States, Israel

Portfolio highlights

Cast21 — The future of orthopedic technology has arrived. Cast21 braces are designed for your active lifestyle.
SweetBio — SweetBio is a Memphis, Tennessee based medical device company specializing in bioengineering honey-incorporated materials for wound care.
Lineus Medical — Lineus Medical is a medical device company focused on reducing IV complications for patients and providers all over the world.

Good Growth Capital is an early-stage venture capital firm known for its expertise in finding, assessing and cultivating complex science and technology.

Investment focus

Health Care, Information Technology, Biotechnology
Seed, Series A, Convertible Note
United States, France, Israel

Portfolio highlights

Liminal — Advanced battery inspection and metrology with ultrasound and machine learning
VenoStent — VenoStent is a clinical-stage tissue engineering company that’s developed tunable, bioabsorbable smart polymer wraps in order to fundamentally transform the 5 million vascular surgeries performed each year.
Aralez Bio — Aromatic noncanonical amino acids that are made using biocatalysis. Single step, enzyme synthesis makes hundreds of tryptophan and other amino acid analogs!

North Coast Ventures (formerly North Coast Angel Fund) is comprised of four contributed capital funds with a focus on early-stage technology investments. Our membership consists of a number of Ohio's leading investors, entrepreneurs, and business leaders who are dedicated to accelerating early-stage ventures.North Coast Ventures members playan active role by generating deal flow, serving on due diligence teams, working with portfolio companies, or serving on the Investment Screening and Executive Committees. Through this involvement, our goal is to provide a supportive environment for our portfolio companies and ultimately enhance the performance of our Fund.Northeast Ohio has a long tradition of active and successful angel investing, but until recently, the success of this crucial form of funding has hinged on the efforts of a relatively small number of individual investors. As the region’s first professionally managed angel fund, North Coast Angel Fund works to improve the early-stage funding environment for both entrepreneurs and investors.

Investment focus

Health Care, Software, Medical Device
Series A, Seed, Funding Round
United States

Portfolio highlights

Narratize — Our generative AI software helps innovative enterprises quickly produce impactful, accurate, compelling communications and deliverables by distilling their ideas and expertise.
Redi.Health — Redi.Health is a healthcare technology company that develops health management platforms for patients. The company aims to connect patients with chronic diseases to patient support programs. These programs are created in partnership with pharmaceutical manufacturers and are always free to the patient.
OnStation — Productivity app for roadway workers and that provides instant jobsite location, access to plans and design, and a team chat platform.

Early Stage Venture Investments

Investment focus

Health Care, Medical Device, Software
Seed, Convertible Note, Series A
United States, Canada, Hungary

Portfolio highlights

Flourish Collective — FlourishFund is a digital platform that empowers and supports new and expecting families. The platform consists of two parts: a marketplace with evidence-based goods and vetted maternal wellness services and a funding mechanism for friends and families to contribute to a positive birth and parenting journey.
Drusolv Therapeutics — Drusolv Therapeutics is a clinical-stage drug company developing a novel, high-dose statin for early intervention in age-related macular degeneration. Their product ocustatin is aimed at patients who are still in the intermediate stage of the disease and currently have very limited options to prevent progression to late-stage vision loss. Ocustatinwas developed at Harvard University and has been validated in a very successful proof-of-concept clinical trial that showed a 75% reduction in progression to late-stage blindness. John Edwards, the founder and CEO of Drusolv, is a serial entrepreneur with extensive experience in AMD.
Vartega — Vartega is a technology development company specializing in the carbon fiber-reinforced plastic recycling process. We have developed alternative technology, processes, and equipment to provide low-cost carbon fiber for use in mass market applications.

Maine Angels they make investments with entrepreneurs with an emphasis on businesses.

Investment focus

Software, Health Care, Biotechnology
Seed, Funding Round, Series A
United States

Portfolio highlights

HighByte — Architect your digital transformation with proven Industrial DataOps software from HighByte. Let's make your industrial data useful.
TOP the organic project — 100% Organic Cotton Period Care. Organic Tampons, Pads, First Period Kit & Bulk Period Products. Women-owned, eco-friendly, plant-based and sustainable. With every subscription, TOP gives back to women in need.
Pumpspotting — connect over breastfeeding, milk, motherhood, and the best places to nurse and pump. nurse, pump, nourish, connect.

Providing Flexible and Creative Financial Solutions to Middle Market Companies.

Investment focus

Biotechnology, Health Care, Medical
Debt Financing, Post-IPO Debt, Series B
United States, United Kingdom, Canada

Portfolio highlights

Amino — Amino's digital healthcare guidance platform provides a fast, easy way to find a doctor, book appointments, and access health benefits.
Headspace — Live a healthier, happier, more well-rested life in just a few minutes a day with the Headspace app.
Pearl Street Dental Management — Pearl Street Dental Management supports non-clinical operations. They provide centralized services such as human resources, payroll, accounting, bookkeeping, finance, lending, facilities management, and information technology services. They address inquiries through online applications, phone calls, and emails.

Boston Harbor Angels is a group of proven business leaders interested in investing a portion of their assets in high growth, early stage companies. The group was formed in February 2004 and since then has made a number of investments in companies in medical devices, IT, consumer products, business products, specialty materials, Internet, aviation,etc. They believe they contribute more than money to the companies they fund and welcome the opportunity to work with entrepreneurs open to take advice, yet having the smarts and determination to make the company successful.Their focus is on early stage companies usually looking to raise $250K to $1.5M, where they can fund a portion of the round and syndicate the deal with other angel groups or early stage venture funds. The stage of the company should be close to commercialization, while the company should have a clear and defensible competitive advantage. They are looking for capital efficient businesses, which can reach profitability with less than $5M of equity investment and provide at least 10X return on the investment within 5 years.They do not invest as a fund - each of their members makes his or her individual investment decision but they collaborate in Due Diligence. They have a deep expertise in the life sciences field where they usually take the position of a lead investor, but are open to any opportunities that can make a strong business case. In some cases they prefer to be the follow on investor if they cannot identify a person with strong expertise within their group.The groupâ€™s strategy is directed by an executive committee which consists of 8 people elected by the group: Wayne Griffith (chairman), Bill McPhee, Henry Kay, Jay Schwartz (membership director), Steve Andress, Peter Miller, Don Freeman and Mic Williams (president and founder). The groupâ€™s day-to-day operations are managed by Boris Batchvarov (managing director).They receive 20-30 business summaries each month, out of which they select 8 companies to make a personal presentation to their screening committee. The screening committee consists of volunteers from the group. The presentations are 10 min long followed by 10 min Q&A. 4 of the companies are invited to present to the whole group, with the idea to get the people interested and decide to perform a Due Diligence with the companies before making an investment.

Investment focus

Biotechnology, Health Care, Medical Device
Angel, Seed, Series A
United States, Canada, India

Portfolio highlights

Zylö Therapeutics — Patented technology that enables, for topicals, sustained release, increased druggability, a Patchless Patch concept, and enhanced targeting of pores and follicles
Xeno Biosciences — Xeno Biosciences operates as a biopharmaceutical company pioneering a novel class of therapeutics to address large unmet needs in metabolic diseases. Lead program, XEN-101, is a first-in-class, oral formulation designed to shift the gut microbiome to the weight-loss associated state induced by Roux-en-Y Gastric Bypass (RYGB) surgery.It wasfounded in 2015 and is headquartered in Somerville, Massachusetts.
Astrocyte Pharmaceuticals — Astrocyte Pharmaceuticals Inc. is a privately held drug development company dedicated to accelerating the recovery and well-being of brain injury patients. The company is committed to proving the neuroprotective benefits of selective astrocyte activation, and advancing breakthrough therapeutic agents for treating brain injury resulting from stroke,TBI, concussion, and neurodegenerative disorders such as Alzheimer’s disease.

For over 20 years we have been a successful healthcare venture capital firm rooted in the Midwest. Check out our portfolio companies.

Investment focus

Health Care, Biotechnology, Medical
Series B, Series A, Series C
United States, Canada

Portfolio highlights

RareCyte — Rarecyte provides precision medicine solutions focused on multiplexed analysis of cells and tissue with applications in both research and clinical diagnostics.
AtaCor Medical — AtaCor Medical - Designing innovative solutions to deliver temporary, interim, and permanent cardiac pacing when, and where it matters most.
Orasis Pharmaceuticals — Discover how Orasis Pharmaceuticals is reshaping vision possibilities with innovative treatments for presbyopia.

TEDCO was created by the Maryland State Legislature in 1998 to facilitate the transfer and commercialization of technology from Maryland’s research universities and federal labs into the marketplace and to assist in the creation and growth of technology-based businesses in all regions of the State. TEDCO is an independent organization thatstrives to be Maryland’s lead source for entrepreneurial business assistance and seed funding for the development of startup companies in Maryland’s innovation economy. In Maryland and beyond, TEDCO is a resource of mentoring, funding and networking for entrepreneurs and start-ups that need guidance as they bring innovative concepts to market. TEDCO is more than an early stage funding resource. It is the hub of Maryland’s entrepreneurial network where startups find mentors, organizational assistance, facilities for daily operations, and a roadmap for success.

Investment focus

Health Care, Software, Biotechnology
Seed, Grant, Pre-Seed
United States, Canada

Portfolio highlights

Relai.ai — Rely on RELAI agents for your AI reliability needs, from model evaluation and debugging to leveraging state-of-the-art system-level and user-facing safeguards.
JuneBrain — JuneBrain's network of tele-health device and AI software products are intentionally designed to work together and optimize remote assessment and monitoring of neurological diseases.
Sybal Corp — Proof of Governance, Patented Enterprise solution designed to measure Policy Effectiveness in real-time and establish immutable record of governance wellness. Governance, Digital Governance, Corporate Governance, Policy, Operational Excellence, GRC

At Connecticut Innovations, we see venture capital the way you see your business. Like no one else. We invest in innovative biotech, IT, and other industries.

Investment focus

Health Care, Biotechnology, Software
Seed, Series A, Funding Round
United States, Israel, Canada

Portfolio highlights

AmpUp — Commercial electric vehicle (EV) charging network solutions made simple for everyone. Easily manage and analyze EV charging data from a single dashboard.
Oxylus Energy — Oxylus Energy provides new carbon utilization technology for the generation of e-fuels It strives to make CO2 capture and conversion competitive, scalable, and circular for a decarbonized future.
Air Company — We are a carbon utilization company working with industries to create planetary change, taking Earth's excess CO2 and converting it into carbon-negative alcohols and fuels.

Wavemaker Three-Sixty Health is the leading U.S. early-stage (Seed and following on at the Series A) venture capital fund focused 100% on healthcare. Launched in 2018, Wavemaker 360 invested into the most promising healthcare startups in North America, with LPs from every sector of the US healthcare system. We are SEEDING HEALTHCARE'STOMORROW. We invest in healthcare disruptors and entrepreneurs that see how the industry is transforming itself and want to make a big difference.

Investment focus

Health Care, Medical, Medical Device
Seed, Series A, Funding Round
United States, United Kingdom, Canada

Portfolio highlights

Feeling Great — Feeling Great is a mental wellness app that offers a revolutionary AI-powered chatbot and interactive learning program, which have been developed based on the groundbreaking work of David Burns, MD and his T.E.A.M. approach to cognitive behavioral therapy.
Marigold Health — Marigold Health is an anonymous social network where people with mental health and substance use conditions support each other.
Materna Medical — Materna Medical empowers women to protect and restore their pelvic health.

We’re (not just) investors.We’re (more than) advisors.We’re (beyond) connectors.Ben Franklin Technology Partners combines the best practices of early stage investing with a higher purpose – to lead the region’s technology community to new heights, creating jobs and transforming lives. For over 30 years, Ben has been the leading seedstage capital provider for the region’s technology sectors, investing over $170 million in more than 1,750 regional technology companies, many of which have gone on to become industry leaders. Ben Franklin has also launched university/industry partnerships that accelerate scientific discoveries to commercialization, and has seeded regional initiatives that strengthen our entrepreneurial community.

Investment focus

Health Care, Software, Information Technology
Seed, Grant, Debt Financing
United States

Portfolio highlights

GrowFlux — GrowFlux, Inc. they offers a ecosystem of commercial scale wireless lighting controls, cloud services, and cloud connected agricultural sensors.
SFA Therapeutics — SFA Therapeutics is a development-stage bio-pharmaceutical startup company focused on a new advancement in the treatment of chronic inflammatory disease - the use of microbiome-derived metabolites as drugs.
Avisi Technologies — Avisi Technologies is developing a nanotechnology-enabled defense against blindness from glaucoma.

Khosla Ventures invests in companies that are bold, early and impactful. The firm was started in 2004 by Vinod Khosla, co-founder of Sun Microsystems, to provide venture assistance to entrepreneurs. Headquartered in Menlo Park, Calif., Khosla Ventures invests in a range of areas including AI, climate, sustainability, enterprise, consumer, fintech,digital health, medtech and diagnostics, therapeutics and frontier technology.

Investment focus

Software, Health Care, Artificial Intelligence
Series A, Series B, Seed
United States, India, United Kingdom

Portfolio highlights

LuxWall — LuxWall is accelerating the global transition to net zero by upgrading windows and glass into transparent insulation for buildings.
RedoxBlox — RedoxBlox offers thermochemical energy storage technology for natural gas power plant operators. It helps power plant operators drastically reduce carbon and nitrogen oxides emissions, its solution integrates with the existing natural gas power plant infrastructure, minimizes impact on plant total capital costs, increases grid resiliency andsafety, and is recyclable, non-toxic, and non-combustible, enabling industries with renewables grid through the deployment of large-scale long-duration energy storage.The company was founded in 2020 and is based in East Lansing, Michigan.
Mooncake Labs — Mooncake Labs is building the modern lakehouse for every developer and application. We are an open source studio based in SF.

Horizon is a venture lending platform that offers structured debt products to life science and technology companies. Its team of investment and operations professionals has been providing debt capital to some of the most exciting companies for decades. The members of the Horizon team have, collectively, originated and invested more than $5 billionin venture loans to thousands of companies.The company was founded in 2003 and is headquartered in Farmington, Connecticut.

Investment focus

Health Care, Biotechnology, Medical Device
Debt Financing, Post-IPO Debt, Funding Round
United States, Canada, India

Portfolio highlights

Unagi Scooters — Unagi is an electric scooter startup that aims to liberate people from the tyranny of transportation frustrations—the costs, inconveniences, the carbon emissions. So we built the ideal personal liberation device.
Evelo Biosciences — Evelo Biosciences is dedicated to improving the lives of patients globally through the development of a new modality of medicines – monoclonal microbials. Monoclonal microbials are orally delivered medicines that modulate systemic immunology and biology through direct interactions with human cells in the gut. These new medicines are broadlyapplicable across many diseases – including autoimmune, immunoinflammatory, metabolic, neurological, neuroinflammatory diseases and cancer. Monoclonal microbials have the potential to fundamentally change traditional models of drug discovery and development. By finding and selecting naturally occurring monoclonal microbials with defined therapeutic effects, Evelo can improve the speed, cost and success of drug discovery and development. Evelo’s platform enables pharmacological intervention at all stages of disease with naturally occurring, safe and effective monoclonal microbials. Evelo Biosciences was conceived and created within VentureLabs®, Flagship Pioneering’s institutional innovation foundry, and launched by Flagship in 2015.
Viken Detection — Viken Detection is a research and technology development company focusing on X-ray physics and the design of analytical devices. The company's devices provide security imaging and material identification, which help to protect the public from terrorism and other dangerous dangers, allowing law enforcement and safety inspection agencies toremain vigilant and avoid drug trafficking.Viken was founded in 2013 and is headquartered in Newton, Massachusetts, United States.

Versant partners with exceptional entrepreneurs to build and fund breakthrough biotechnology companies around the globe.

Investment focus

Biotechnology, Health Care, Medical
Series A, Series B, Series C
United States, Switzerland, Canada

Portfolio highlights

858 Therapeutics — 858 Therapeutics is a stealth company specializing in the area of healthcare services, pharmaceutical, and biotechnology. The company was founded in 2019 and is headquartered in San Diego, California, USA.
Borealis Biosciences — Borealis Biosciences was founded on the premise that a convergence of scientific and translational breakthroughs is enabling the field of RNA medicines to treat kidney diseases and beyond. The company is backed by founding investor Versant Ventures and Novartis AG, and has a strategic collaboration with the pharma.
Bright Peak Therapeutics — Bright Peak is a biotech company that develops a portfolio of immunotherapies for the treatment of cancer and autoimmune diseases. At Bright Peak, they are creating innovative cytokine therapeutics that are uniquely engineered to precisely control and expand desired biological properties.

U.S. Venture Partners (USVP) is a venture capital partnership, helping entrepreneurs transform their ideas and efforts into world-changing companies. The firm focuses on early-stage ventures in information technology and health care, where innovation is unbridled and has led to the creation of economic wealth and millions of jobs over the pastthirty-plus years of the firm's existence. Areas of particular interest to our investment professionals include enterprise software, IT security, consumer internet, mobile, and e-commerce, healthcare, and IT-enabled healthcare services. The USVP team consists of former entrepreneurs, technologists, corporate executives, financial professionals, and industry domain experts.

Investment focus

Software, Health Care, Information Technology
Series B, Series C, Series A
United States, Israel, Canada

Portfolio highlights

Stream Security — Empowering organizations to code and deploy configurations faster and safer, from plan to production.
Sepio — Sepio provides full asset visibility. Sepio's Asset Risk Management sees, assesses and mitigates risk for all known and shadow IT assets.
Sparrow Pharmaceuticals — Sparrow Pharmaceuticals is an emerging clinical-stage biopharmaceutical company developing novel, targeted therapies for disorders of corticosteroid excess.

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Investment focus

Health Care, Biotechnology, Pharmaceutical
Series B, Series C, Series A
United States, Germany, Switzerland

Portfolio highlights

Paperspace — Ceres, Inc. (Ceres) is an agricultural biotechnology company selling seeds to produce renewable biomass feedstocks. The Company’s large-scale commercial products are sweet sorghum varieties that can be used as a drop-in feedstock to extend the operating season of Brazilian sugarcane-to-ethanol mills. Its products include sweet sorghum, high biomasssorghum, switchgrass, miscanthus and row crops. Its energy crops can also be used for the production of second-generation biofuels and bio-based chemicals, including cellulosic ethanol, butanol, jet fuel, diesel-like molecules and gasoline-like molecules, from non-food biomass. Baseload utility scale electric power can also be generated from the biomass feedstocks grown from its seeds. Ceres has sold switchgrass and high biomass sorghum seeds in the United States under its Blade Energy Crops (Blade) brand. In January 2010, the Company incorporated a subsidiary, Ceres Sementes do Brasil Ltda.
CardioFocus — CardioFocus is a biotechnology company that focuses on the advancement of ablation treatments for cardiac disorders. The company specializes in providing electrophysiologists with innovative and effective tools that bring new levels of precision and control to the treatment of atrial fibrillation that focuses on developing, manufacturing, andinvestigating disposable fiber optic catheters for the visualization of the cardiac anatomy and the treatment of cardiac arrhythmias.CardioFocus was founded in 1990 and is headquartered in Marlborough, Massachusetts.
Yolia Health — Yolia Health developed The True Vision Treatment or TVT, the 'Invisalign' for the eyes. A non-invasive treatment to correct vision problems like presbyopia without surgery. TVT is self-administered by the patient in his or her own home. It employs a combination of customized contact lenses (TVT Contacts) and specially formulatedeye drops (TVT Eye Drops). After only 5 days of treatment with TVT patients are able to stop using the TVT Contacts, TVT Eye Drops and their reading glasses for up to 12 months at a time before re-treatment with TVT is needed. What is even greater than correcting for presbyopia non-invasively, is correcting both eyes without compromising any distance vision. On the contrary, Yolia's treatment improves both near and distance vision, a unique feature no single other alternative can provide. ** Looking for sophisticated investors and key industry partners.

Foundational partners to ambitious founders at every stage of company-building.

Investment focus

Software, Health Care, Biotechnology
Series B, Series A, Series C
United States, India, China

Portfolio highlights

Sana — Sana is an AI company building the next generation of knowledge tools. Designed and engineered in Stockholm, Sweden.
Outrider — Autonomous yard operations have set a new standard. Yard automation transforms yard operations into an efficient, safe, and sustainable solution.
Pathos — Pathos is a clinical-stage biotechnology company focused on re-engineering drug development with the power of advanced AI technologies.

The Houston Angel Network (HAN) is a nonprofit organization dedicated to developing the innovation ecosystem in Houston, Texas by supporting founders and startups with financial resources and mentorship.

Investment focus

Health Care, Software, Information Technology
Seed, Funding Round, Series A
United States, Canada, United Kingdom

Portfolio highlights

Prana Thoracic — A minimally invasive, lung-sparing device that will provide physicians and patients with the certainty they need to move forward with treatment.
Materna Medical — Materna Medical empowers women to protect and restore their pelvic health.
Amplified Sciences — Providing innovative diagnostic tests that enable earlier detection, risk stratification and monitoring of challenging diseases.

Catalyst Health Ventures is an early-stage venture capital firm targeting technology solutions applied within the health care and life science industries. At the core of this strategy is a committed, hands-on approach to working with management and syndicate partners to build successful companies. Their disciplined investment process leverages bothintellectual and financial capital to originate deals, cultivate opportunities, and realize the full potential of emerging ventures in the health care and life science marketplace. We seek to invest in companies addressing major global unmet clinical needs in areas such as oncology, cardiovascular disease, obesity, and women’s health. We invest in pioneering and proprietary technological solutions fundamentally designed to reduce treatment costs and improve patient outcomes. By investing in solutions which have a technological foundation of engineering and development such as medical devices, diagnostic tools and instrumentation and consumer healthcare, we minimize the risks related to uncertain scientific experimentation.

Investment focus

Health Care, Medical Device, Medical
Series B, Series A, Series C
United States

Portfolio highlights

AtaCor Medical — AtaCor Medical - Designing innovative solutions to deliver temporary, interim, and permanent cardiac pacing when, and where it matters most.
Venova Medical — Venova Medical, Inc. is a privately held company addressing the challenges associated with providing optimal vascular access for patients that need hemodialysis.
Brixton Biosciences — Brixton Biosciences is a biotechnology company currently operating in stealth mode.

Wisconsin Investment Partners is an Angel Investment Group in Madison, Wisconsin founded in 2000 with 20 members. Membership has grown to 50+ members in recent years, bringing significant knowledge and experience.

Investment focus

Health Care, Biotechnology, Medical
Funding Round, Seed, Series A
United States, Canada, United Kingdom

Portfolio highlights

Flyte — Flyte promotes cellular healing in pelvic floor muscles for lasting results. Flyte is fast, proven, safe, pelvic floor therapy for bladder control.
BeeReaders — ## Build Setup
Midwest Games — Midwest Games is a video game publisher focused on creating opportunities for the abundant talent across the Midwest and other underrepresented regions.

Canaan is an early stage venture capital firm that invests in entrepreneurs with visionary ideas. With $5B under management, a diversified fund and over 190 exits to date, Canaan has invested in some of the world's leading technology and healthcare companies over the past 30 years. Canaan’s focus areas include fintech, enterprise/cloud,marketplaces, frontier tech, biopharma, digital health, and medtech.

Investment focus

Software, Biotechnology, Health Care
Series A, Series B, Series C
United States, United Kingdom, Israel

Portfolio highlights

Glooko — Glooko's digital health and connected care solutions improve health outcomes for people with diabetes and related chronic conditions.
AttoTude — AttoTude is a pioneer in the creation of novel connection technology for AI and hyperscale data center applications. The company is developing a distinctive technology for high-speed data networking that will overcome the constraints of current interconnect systems, including considerable increases in bandwidth, power dissipation, reliability, andcost.
Safire Technology Group — SAFIRE, our patented li-ion shear thickening battery electrolyte additive stops explosion/fire through an instantaneous liquid-to-solid transformation upon mechanical impact, and imparts ballistic protection -- all inherent in the electrolyte chemistry.

Catalyst Health Ventures is an early-stage venture capital firm targeting technology solutions applied within the health care and life science industries. At the core of this strategy is a committed, hands-on approach to working with management and syndicate partners to build successful companies. Their disciplined investment process leverages bothintellectual and financial capital to originate deals, cultivate opportunities, and realize the full potential of emerging ventures in the health care and life science marketplace. We seek to invest in companies addressing major global unmet clinical needs in areas such as oncology, cardiovascular disease, obesity, and women’s health. We invest in pioneering and proprietary technological solutions fundamentally designed to reduce treatment costs and improve patient outcomes. By investing in solutions which have a technological foundation of engineering and development such as medical devices, diagnostic tools and instrumentation and consumer healthcare, we minimize the risks related to uncertain scientific experimentation.

Investment focus

Health Care, Medical Device, Medical
Series A, Series B, Series C
United States

Portfolio highlights

Epitel — Epilog is an unobtrusive wearable seizure detection system that records long-term EEG, anywhere. It gives people living with epilepsy peace of mind with a much-needed tool to better understand and manage their seizures.
Avive Solutions — Check out Avive Solutions, the manufacturers of a brand new AED machine - portable defibrillator - that's FDA approved!
PanTher Therapeutics — PanTher Therapeutics is on a mission to revolutionize cancer care with a proprietary treatment platform designed to enhance therapeutic response with minimal side effects. PanTher’s highly adaptable platform empowers oncologists to treat patients with life-threatening cancer by unlocking a drug’s full potential through direct, sustained treatmentat the tumor site. This distinctive targeting capability uniquely positions PanTher to take on the deadliest and most difficult to treat cancers with a lead investigational candidate in pancreatic cancer.

Delphi Ventures leverages years of experience, passion, & expertise to advance new technologies and build market leading biotechnology companies.

Investment focus

Health Care, Biotechnology, Medical Device
Series C, Series B, Series D
United States, Canada, Denmark

Portfolio highlights

MyShell — The first AI consumer layer - build, share, and own AI Apps.
Pixelmon — Collect, Evolve & Battle alongside your Pixelmon in our Multiplayer Open World Adventure and Monster Combat Arena.
Arrow Markets — Arrow markets is a first-of-its-kind hybrid web3 options platform, optimized for user experience (UX). Arrow pricing and hedging is implemented through a network of market makers, while settlement, ownership and transfers are handled on the Avalanche C-chain. The Arrow options trading UX is the product of three years of research, user interviews and design iteration, providing a simple entry point for new traders and an intuitive flow for pros.

For over two decades, Sand Hill Angels has worked openly and collaboratively with venture capital funds, other angel organizations, and the Bay Area ecosystem that fosters the growth of technology startups.

Investment focus

Health Care, Software, Biotechnology
Seed, Series B, Series A
United States, Canada, Japan

Portfolio highlights

Pulzaid — Platform for hybrid specialty care
GaeaStar — The zero waste clay cup. GaeaStar is an engineering company developing sustainable multiple use products and technology.
PrivacyHawk — PrivacyHawk is a Personal Data Protection service that makes opting out, unsubscribing, and deleting your data from thousands of companies easy.

Split Rock Partners invests in emerging healthcare, software and Internet services companies in the Upper Midwest and West Coast. They are an early-stage venture capital firm that was founded in June 2004 by the former healthcare and software investment teams of St. Paul Venture Capital (SPVC). The Split Rock team managed over $1 billion of venturecapital during our tenure at SPVC, and continues to manage the SPVC healthcare and software portfolio. In May of 2008, they raised $300 million in the second Split Rock Partners fund, the successor to their inaugural $275 million fund raised in April 2005.The Split Rock team believes that it takes great people to translate promising ideas into compelling businesses. They are grounded in a fundamental respect for entrepreneurs and the rare combination of elements required when pioneering new markets. They start by looking for entrepreneurs with the passion, vision, and skills to build leading companies. They then work with entrepreneurs collaboratively, building partnerships based on integrity and mutual respect. The Split Rock team complements management expertise with over 80 years of venture investing and entrepreneurial management experience. They are proud of the strong relationships they have built with talented entrepreneurs and co-investors throughout their history and look forward to building on that tradition.

Investment focus

Health Care, Medical Device, Medical
Series A, Series B, Series C
United States, France

Portfolio highlights

Gravia — More benefits. Fewer asterisks. We are a health benefits company on a mission to build a health plan that everyone can love.
EBR Systems — EBR aims for outstanding treatment of cardiac rhythm diseases with an innovative leadless therapy.
Gravie — More benefits. Fewer asterisks. We are a health benefits company on a mission to build a health plan that everyone can love.

Kleiner Perkins is an American venture capital firm headquartered on Sand Hill Road in Menlo Park in Silicon Valley.

Investment focus

Software, Health Care, Information Technology
Series B, Series A, Series C
United States, China, United Kingdom

Portfolio highlights

Nooks — Working with your team should be enjoyable & energizing. Nooks is the virtual office for your team to skip the fatiguing meetings and bring back impromptu collaboration & casual conversations.
Browserbase — Browserbase is a comprehensive platform for developers to host, administer, and monitor headless browsers in the cloud.
Infinitus Systems — Infinitus Systems offers Voice Robotic Process Automation (VoiceRPA) software for businesses in the healthcare industry.

The St. Louis Arch Angels is a network of accredited investors who fund early-stage businesses across the St. Louis region.

Investment focus

Biotechnology, Health Care, Medical Device
Seed, Series A, Funding Round
United States, Argentina

Portfolio highlights

Peptyde Bio — Peptyde Bio is an Agtech startup positioned to become the go-to supplier of new AMPs.
SentiAR — SentiAR is digital health, software device company adding a new dimension to clinical practice in interventional procedures. Spun out of Washington University, we are developing the first 3D visualization platform using real-time holography of the patient's anatomy and catheter location, "floating" over the patients, with a goal toprovide the clinician and patient a faster, safer delivery of care.SentiAR’s mission is to transform the experience for both patient and clinician in interventional procedures with a 3D augmented reality platform featuring real-time holographic visualization of the patient’s actual anatomy, “floating” over the patient.The visualization is fully controllable “hands-free” by the clinician, providing an ergonomic breakthrough for the treatment and analysis of cardiac arrhythmias within an interventional catheter lab environment. SentiAR is developing the platform for eventual FDA submission.
Maximum Fidelity Surgical Simulations — The most realistic surgical and trauma simulations for surgeons, forward field operators, medics and medical device development.

Gaingels is a leading venture investment syndicate in support of diversity, inclusive of the LGBTQIA+ community and allies in the venture capital space.

Investment focus

Software, Health Care, Artificial Intelligence
Seed, Series A, Series B
United States, Canada, Mexico

Portfolio highlights

MealMe — MealMe: We compare services for delivery pickup and groceries to ensure that we are the fastest food delivery app, the cheapest food delivery app, and the food delivery app with the largest selection.
Further — Further is on a mission to empower first-time home buyers to achieve their dream of homeownership with confidence and ease. We simplify the complex home buying process through innovative tools and personalized guidance, ensuring that buyers are well-prepared every step of the way. Our platform offers financial planning, tailored insights, andresources designed to make homeownership more accessible. At Further, we believe that with the right support, anyone can realize their goal of owning a home. Join us as we help make the path to homeownership clear and attainable for all.
Wildfire Systems — We are the only white-label cashback and shopping rewards loyalty platform that helps companies monetize e-commerce everywhere.

Life Science Angels, Inc. (LSA) is the premier angel investment group focused solely on healthcare investing, including medical devices, diagnostics, pharmaceuticals, biotechnology, and digital health.

Investment focus

Biotechnology, Health Care, Medical
Funding Round, Seed, Series A
United States, Israel, The Netherlands

Portfolio highlights

Neurava — Neurava has developed wearable diagnostics for epilepsy patients including those at risk of SUDEP. The company specializes in the fields of medical device manufacturing, healthcare, and health diagnostics.
InnoSIGN — We are passionate to bring to market our OncoSIGNal pathway activity profiling technology contributing to a better understanding of disease mechanisms in oncology. OncoSIGNal enables next generation precision medicine by translating molecular data into functional cell behavior.
Avisi Technologies — Avisi Technologies is developing a nanotechnology-enabled defense against blindness from glaucoma.

Tech Coast Angels is the largest angel investor group in the United States, possessing more than 300 members in five networks in Los Angeles, Orange County, San Diego, Central Coast, and the Inland Empire. Its members provide funding and guidance to more early-stage, high-growth companies in Southern California than any other investment group.Members invest in companies in a wide range of industries, including the life sciences, biotech, IT, services, retail, Internet, financial, software, media, consumer products, and tech startups. TCA as a whole gives companies more than just capital; they also provide counsel, mentoring, and access to an extensive network of potential investors, customers, strategic partners, and management talent. Tech Coast Angels has been ranked by CB Insights to be among the Top 20 Angel Groups in the US; TCA was also ranked as #1 for Network Centrality, meaning we have more connections than anyone! If you are in the game-changing business, we are here to help.

Investment focus

Software, Health Care, Biotechnology
Seed, Convertible Note, Funding Round
United States, Canada

Portfolio highlights

Reglagene — Reglagene is a therapeutics company that leverages its expertise in the design and development of brain penetrant medicines to create breakthrough therapies for the safe and effective treatment of brain diseases.
RealSeq Biosciences — We're discovering new biomarkers to advance next-generation diagnostics that provide deeper insights and improve more lives.
Trio Pharmaceuticals — Trio Pharmaceuticals is a cancer therapeutics company that develops dual-action drugs for immunogenic tumors. These drugs directly stop tumor growth and selectively stop immunosuppression in the tumor without targeting the current immune checkpoint pathways. The company was founded in 2018 and is headquartered in San Diego, California.

Three Arch Partners was formed in 1993 to provide young companies with access to relevant clinical and business resources, as well as capital. Three Arch has helped create, build and fund more than 100 important new healthcare companies. These companies have often become the clinical and market leaders in their respective fields, and have generatedstrong returns. The fund focuses on opportunities in medical devices and healthcare services, and less frequently in biotechnology.

Investment focus

Health Care, Biotechnology, Medical Device
Series B, Series C, Funding Round
United States, Belgium

Portfolio highlights

Nevro — We Believe True Innovation Transforms More Lives
Neuronetics — Neuronetics is focused on developing non-invasive therapies for psychiatric and neurological disorders using MRI-strength magnetic field pulses. They are the first and only company to have a non-systemic and non-invasive depression treatment cleared by the FDA for patients who have not benefited from prior antidepressant treatment.
Access Closure — Access Closure, Inc., a medical device company, provides access site management products to address the complex challenge of vascular closure during interventional and diagnostic procedures. The company's products include Mynx delivery system, a vascular closure device that seals the arteriotomy using a water-soluble and extravascular sealant,which expands in the tissue tract by absorbing blood and subcutaneous fluids. Access Closure, Inc. was founded in 2002 and is based in Mountain View, California.

Keiretsu Capital LLC is an affiliate of the World's Leading Angel Network, Keiretsu Forum, and manages funds which enable limited partners to co-invest in the proprietary deal flow of the angel investors.

Investment focus

Health Care, Biotechnology, Medical
Funding Round, Series A, Seed
United States, Canada, India

Portfolio highlights

Clensta — Clensta is a biotechnology start-up to improve the National Hygiene condition whilst addressing the aspect of water conservation. Clensta is an Indian startup and in association with IIT Delhi, works to create innovative healthcare solutions to make hygiene accessible for anyone, anytime, and anywhere. Driven by their aim to create products thatpromote complete cleaning solutions without water.
Healionics — Healionics aims to provide safer, more reliable means of bloodstream access for dialysis in patients with kidney failure.
Another Tomorrow — Conscious Clothing. Education. Action. Another Tomorrow pushes the boundaries of what responsibly grown, and ethically manufactured materials can achieve. Sensual and strong, our collection is designed for living.

AMV is the leading early-stage venture capital firm investing in digital health, technology and life sciences. It has assembled the leading early-stage

Investment focus

Health Care, Biotechnology, Software
Series A, Seed, Series B
United States, Cyprus, Ireland

Portfolio highlights

basys.ai — Basys.ai automates the process of prior authorization and utilization management to improve costs and timeliness for health plans/payers using an AI-based platform. The proprietary platform automates the process of encoding/digitizing the payer policies using machine learning, thus reducing the piloting timeline by up to 9 months.
Autonomize AI — Autonomize AI is a human-centric AI platform that learns from multi-structured clinical and biomedical data and pairs it with human context to aid decision-making and data discovery. They extract contextual information from multi-structured healthcare data, enrich with human know-how, and aid decision-making and data discovery.
Endless Health — We are a one-stop-shop for cardiovascular health. Empower yourself with research-backed info on your heart condition and how to prevent progression. Connect with a certified healthcare professional via video chat, messaging, and goal-setting to stay accountable. Stay in control of your health journey with a single dashboard that combines key dataand behavior tracking. Share with ease.

Silicon Valley Bank is the financial partner of the innovation economy; helping individuals and investors in the innovation ecosystem achieve extraordinary outcomes.

Investment focus

Software, Health Care, Biotechnology
Debt Financing, Series B, Series A
United States, United Kingdom, Canada

Portfolio highlights

Lithios — Lithios is developing systems based on breakthroughs in electrochemistry to selectively capture and release lithium from complex mixtures.
Bugcrowd — Bugcrowd teams with elite security researchers to reduce risk & improve security ROI through our bug bounty, pen testing, & vulnerability disclosure programs.
DataPelago — DataPelago provides big data analytics solutions. They also provide a data analytics platform that offers hardware and software based products. The platform also provides solutions for extracting insights from data of, speed, or structure at performance and cost levels unsurpassed in the industry.

The Vertical Group is a New Jersey-based venture capital firm focused on the fields of medical technology and biotechnology.

Investment focus

Health Care, Medical Device, Medical
Series B, Series C, Funding Round
United States, Israel

Portfolio highlights

Luminopia — Luminopia is the first FDA-approved binocular therapy for amblyopia.
MicroTransponder — MicroTransponder is a medical device company that develops and commercializes neurostimulation devices to treat neurological diseases. Its therapies include paired vagus nerve stimulation system (Paired VNS System) and wireless neurostimulation system for the treatment of chronic pain, post-stroke upper limb mobility issues, and variousneurological indications that enable healthcare practitioners to treat post-stroke upper limb mobility issues.Founded in 2007, MicroTransponder is headquartered in Dallas, Texas.
Route 92 Medical — The official website for Route 92 Medical.

Virginia Venture Partners is a family of seed-stage investment funds placing near-equity and equity investments in Virginia-based technology, life science, and cleantech companies. Virginia Venture Partners invests in companies with a high potential for achieving rapid growth and generating significant economic returns for entrepreneurs,co-investors, and the Commonwealth of Virginia. CIT’s family of funds includes:GAP Fund I is a vintage 2004 fund fully invested in a broad array of seed-stage technology companies. Portfolio.GAP BioLife Fund is a seed fund investing exclusively in life science companies.GAP Tech Fund is a seed fund investing in IT and technology companies.

Investment focus

Software, Health Care, SaaS
Seed, Funding Round, Series A
United States, Canada, France

Portfolio highlights

Syntrillo — Stroke is the leading cause of long-term disability worldwide, but it doesn’t have to be. We know that with the right kind of care, 8 out of 10 strokes could be prevented. Through a combination of digital health and AI, we are making expert-level care accessible to millions of at-risk patients. Our team of neurologists, rehabilitation experts, andpsychologists have made it our mission to improve your brain health and protect against stroke.
Bricklayer.ai — Bricklayer AI is the first automated AI security team. Run better, faster, more efficient security operations with AI agents alongside humans.
Thumbprint Furniture — Thumbprint is dedicated to simplifying the commercial furniture design and specification process.

Morgenthaler Ventures has been in the venture capital business for more than 45 years, steadily investing through every market cycle. Select past and present portfolio companies in the IT space include: Evernote, Lending Club, Siri, MuleSoft, Practice Fusion, Adara Media, Check, Doximity, PeopleMatter, Socrata, NuoDB, Jaspersoft, VoltageSecurity, Rhythm NewMedia, Nominum, Wize Commerce (NexTag) and back in the day, Apple.

Investment focus

Health Care, Biotechnology, Medical
Series B, Series A, Funding Round
United States, Canada, France

Portfolio highlights

Moximed — Moximed Inc. is dedicated to improving the standard of care for patients with osteoarthritis, and is investigating therapies to treat a number of affected joints. The lead product, the KineSpring® Knee Implant System, is designed for patients with knee osteoarthritis.
SetPoint Medical — SetPoint Medical is pioneering bioelectronic medicine to develop a safe and cost-effective approach for treatment of chronic autoimmune diseases.
Relievant Medsystems — Relievant's mission is to provide patients with low risk therapy that can alleviate their back pain.

DeNovo Ventures was formed in 2000 by seasoned investors and experienced medical device entrepreneurs who sought to share the lessons learned from a history of successful investing and building successful companies. They believed that their unique combination of skills and perspectives could help entrepreneurs to build companies which would havesignificant clinical impact and generate superior returns. Seven years later, this belief continues to hold true, demonstrated by investment success in selected medical device and biotechnology companies. With $650 million under management, De Novo has made more than 40 investments in medical devices and biotechnology across three funds. They invest in all stages of enterprise development and growth â€“ from early stage to late stage. The unique background of leading companies as entrepreneurs and operating executives from start to exit enables us to advise entrepreneurs and management teams over the full life cycle of the company.

Investment focus

Health Care, Medical Device, Biotechnology
Series B, Series D, Series C
United States

Portfolio highlights

Avedro — Glaukos works relentlessly to create and deliver transformative therapies for patients struggling with glaucoma, corneal disorders, and retinal diseases.
Milo — Milo is a group action communicator, sophisticated wireless networking, audio processing & powerful hardware in a carefully crafted design.
Spinal Kinetics — The artificial disc replacement device from Orthofix is changing the lives of people suffering from spinal pain. Learn about this motion-saving product.

Rev1 Ventures provides seed stage venture capital funding in Columbus, Ohio along with startup services, space, mentoring, and connections. Learn more!

Investment focus

Software, Health Care, Information Technology
Seed, Series A, Funding Round
United States, Germany

Portfolio highlights

HubiFi — SaaS Financial Automation & Analysis for High Transaction Businesses
Myoptechs — Myoptechs, a pediatric ophthalmic medical device startup in the clinical stage, has made advancements in its fund-raising and clinical research program. The company creates innovative soft contact lenses and spectacles that reduce the growth of myopia while offering incredibly clear vision.
Power to Hydrogen — Power to Hydrogen (P2H2) is simplifying hydrogen. Our technology enables a brighter energy future by solving the technical and economic challenges that come with producing hydrogen. Our AEM-based, electrolysis technology produces high pressure, high efficiency hydrogen from renewable energy with lower cost materials thancompeting electrolyzers. This technology can reduce the total cost of hydrogen to enable clean transportation, store energy efficiently, and decarbonize industrial processes. In addition to low-cost, high-pressure hydrogen production, the technology can produce high-pressure oxygen and be used reversibly to produce electricity. Both services can create additional revenue streams to make the total cost of hydrogen $1/kg.

Keiretsu Forum is a global angel investor network with more than 2,500 accredited investor members throughout 47 chapters on 3 continents.

Investment focus

Health Care, Software, Biotechnology
Funding Round, Seed, Series A
United States, India, Turkey

Portfolio highlights

ALM Ortho — ALM Ortho, a Patient Matched Device Solutions Company
Unibloom World — Unify targets with operational projects, make scenario simulations with cost impact in real time, compare new ideas, optimise actions and turn it into actionable projects with clear financial, regulations and business impact. Release burden from Sustainability Teams!
AutoNxt Automation — Discover the future of sustainable farming with Autonxt Automations electric tractors and self-driving technology. Explore our innovative solutions today.

ShangBay Capital is a venture capital company that brings best-in-class investments mainly in the U.S. medical devices technology, as well as biotech, and mobile healthcare sectors through early-stage venture equity participation

Investment focus

Health Care, Medical Device, Biotechnology
Series A, Series B, Series C
United States, China, Canada

Portfolio highlights

Venova Medical — Venova Medical, Inc. is a privately held company addressing the challenges associated with providing optimal vascular access for patients that need hemodialysis.
Avation Medical — Avation Medical is an innovative advanced neuromodulation & digital health company pioneering wearable neuromodulation therapies.
Laplace Interventional — Laplace developing Transcatheter Tricuspid Valve Technology to offer an increase in life expectancy and an improvement to the quality of life to worldwide patients with tricuspid regurgitation.

Privately Held Companies

Investment focus

Health Care, Biotechnology, Medical
Series A, Series B, Series C
United States, Canada, New Zealand

Portfolio highlights

Endogenex — DyaMX is an early stage medical device company focused on the treatment of Type 2 Diabetes
Solu Therapeutics — Solu Therapeutics is a precision-medicine-focused company developing therapeutics to eliminate disease-driving cells.
Reprieve Cardiovascular — Reprieve Cardiovascular is bringing intelligence to decongestion management to safely accelerate fluid removal for heart failure patients.

Third Rock Ventures is a leading healthcare venture firm focused on advancing disruptive areas of science and medicine to deliver breakthroughs to patients.

Investment focus

Biotechnology, Health Care, Therapeutics
Series A, Series B, Series C
United States

Portfolio highlights

Marea Therapeutics — Marea Therapeutics is a clinical-stage biotechnology firm that uses the most recent advancements in human genetics to create first-in-class, next-generation medications for cardiometabolic illnesses.
Candid Therapeutics — Candid Therapeutics is a biotechnology company that focuses on the treatment of a range of immunological conditions.
Seaport Therapeutics — Seaport Therapeutics operates as a clinical stage biopharmaceutical company.