Top 50 Biotechnology VC Funds & Investors in United States (August 2026)

Portfolio highlights

• Synchron — The endovascular brain computer interface.
• Parabilis Medicines — Parabilis Medicines is a biopharmaceutical company in the clinical stage that focuses on developing exceptional medications targeting challenging protein structures previously deemed undruggable. Utilizing more than ten years of exclusive data, innovative laboratory techniques, and algorithms based on AI and physics, the company has introduced anovel category of stabilized, cell-penetrating alpha-helical peptides known as Helicons™. These peptides can modulate intracellular proteins that traditional drug modalities cannot reach.
• LifeMine Therapeutics — LifeMine is a clinical-stage biopharmaceutical company pioneering a bold new approach, Top-Down Drug DiscoveryTM, which leverages evolutionary insights from fungi to unearth next-generation precision medicines.

Portfolio highlights

• MixRift — MIXRIFT - game developers specialized in Mixed Reality
• unspun — From 3D scan to perfect fitting custom jeans. unspun makes each pair of jeans unique to your actual body and design. On a mission to reduce global carbon emissions by 1%. As seen in Fast Company's World Changing Ideas, Time's Best Inventions, and PopSci's Best of What's New. Welcome to the future of apparel.
• Mesa Quantum — Unlock the potential of chip-scale quantum sensing for enhanced Position, Navigation, And Timing capabilities. Explore Mesa Quantum's practical solutions.

Portfolio highlights

• Triveni Bio — Triveni Bio is at the forefront of human genetics, cutting-edge antibody design, and precision medicine, pioneering the identification of new disease targets.
• Vedana Therapeutics — Vedana Therapeutics is a Seattle biotechnology company developing next-generation antibody therapies for migraine prevention.
• CREATE Medicines — Myeloid Therapeutics is an immunology company focused on combining immunologic insights with cutting-edge technologies to harness myeloid cells to eradicate cancer and other diseases. The Company's ATAKTM platform technology can be broadly applied, and it is initially advancing a cell therapy program for T cell lymphoma and a primed monocyteapproach to treat glioblastoma. The ATAK platform is scalable to multiple treatment modalities and other disease areas in collaboration with partners.

Portfolio highlights

• CardiAQ Valve Technologies — CardiAQ Valve Technologies (CVT), a privately held company, is developing innovative approaches to heart valve replacement and is initially focused on transcatheter mitral valve implantation (TMVI).
• Sonendo — Sonendo developing innovative technologies to transform dentistry by Saving Teeth Through Sound Science®. The GentleWave® System shows significant improvements in clinical efficacy and practice efficiency when compared to standard root canal treatment.1,2, 3 Sonendo is the parent company of TDO® Software, the developer of the most widely usedendodontic practice management software in the world, designed to simplify practice workflow. TDO software seamlessly integrates practice management, imaging, social media, referral reporting, CBCT imaging, and offers built-in communication with the GentleWave System.
• Acceleron Pharma — At Merck, we're following the science to tackle some of the world's greatest health threats. Get a glimpse of how we work to improve lives.

Portfolio highlights

• Tabs — Tabs provides AI-powered accounts receivable software to save time analyzing contracts, improve cash flow, and avoid billing errors.
• Enact — Enact is a leading solar energy and solar software company serving homeowners, businesses, and installers. Get a free quote or request a demo today!
• Beam — Smarter employee benefits including dental, vision, life, disability, and supplemental health. Our plans are easy to understand, implement, and use.

Portfolio highlights

• E Ink — E Ink Corp. is a supplier of electronic paper display (EPD) technologies. Products made with E Ink's electronic ink are designed to possess a paper-like high contrast appearance, ultra-low power consumption, and a thin, light form. E Ink's technology is tailored for many consumer and industrial applications including handheld devices,watches, clocks, and public information and promotional signs.
• Songbird — DropCatch.com helps you secure expiring domain names.
• Ethyreal Bio — Ethyreal Bio is an early-stage biotechnology company developing precision, mechanism-driven therapies for thyroid diseases with high unmet medical needs.

Portfolio highlights

• Corvia Medical — Corvia Medical is a medical device company, focuses on developing structural heart devices for the treatment of heart failure. The company develops InterAtrial Shunt Device (IASD), a transcatheter device designed to treat diastolic heart failure (DHF), also known as heart failure with preserved ejection fraction (HFpEF). It was founded in 2009and headquartered in Andover, Massachusetts.
• NinePoint Medical — NinePoint Medical, Inc. is a transformational medical device company developing innovative, real-time, in vivo pathology devices. The company's first goal is to develop a device that enables remote pathology, or telepathology, which would facilitate immediate review of images during diagnostic procedures. This capability could potentiallyprovide physicians with immediately actionable information and eventually allow them to pursue therapeutic remedies at the time of diagnosis. This convergence of access, diagnosis and treatment during one procedure is expected to improve patient experiences and outcomes, improve the efficiency of care and provide important savings to the healthcare system. Headquartered in Cambridge, Mass., NinePoint is backed by Third Rock Ventures and Prospect Venture Partners.
• CytomX Therapeutics — CytomX Therapeutics is a biotechnology company that focuses on developing proteolytically-activated antibodies. Their mission, alone and with the help of partners, is to provide patients with more effective and less toxic therapies for severe illnesses such as cancer and inflammatory diseases.

Portfolio highlights

• Graphite Bio — Graphite Bio is a next-generation gene editing company focused on therapies that harness targeted gene integration to treat or cure serious diseases
• Dayra Therapeutics — Dayra Therapeutics manufactures peptide based medicines.
• Jecure Therapeutics — Jecure Therapeutics is focused on the discovery of innovative therapeutics for the treatment of non-alcoholic steatohepatitis.

Portfolio highlights

• Lob — Lob provides direct mail and address verification APIs that allow businesses to send timely, personalized, automated offline communications to their customers.
• Jibe — ICIMS is a leading talent acquisition platform offering AI-powered applicant tracking, candidate engagement, onboarding, employer branding, and career site software to help organizations hire top talent at scale.
• Partnerware — Partnerware maximizes speed-to-market™ for channel-focused companies with the leading B2B Partner Relationship Management (PRM) solution, delivering measurable channel results in Internet time. As a multi-channel sales approach becomes critical in delivering value-added solutions to the marketplace, the need for PRM has grown dramatically.Partnerware provides distinct benefits for companies looking to leverage the power of indirect - Faster channel execution (from channel recruiting to product launches)- Measurable results from partner programs, channel marketing funds, and partner sales efforts- Increased market responsiveness to leap frog and stay ahead of competition- Easy implementation by deploying Web-based Partner Relationship Management solutions in Internet time

Portfolio highlights

• NeuroPace — The NeuroPace RNS System is the only FDA-approved epilepsy device that delivers personalized treatment by responding to abnormal brain activity and provides EEG data that can help improve patient care.
• Packeteer — Packeteer is a global leader in WAN Application Delivery and WAN Optimization. The company offers an integrated family of appliances and software products. Packeteer is a provider of network software products that enhance mission-critical application performance over enterprise WANs and the Internet. These application-adaptive bandwidth managementsolutions give businesses and service providers per-application control of bandwidth at congested WAN access links.
• Alteon Websystems — Alteon Websystems is a computer network hardware company that provides internet infrastructure solutions enabling e-businesses to meet their increasing demands.  The company’s portfolio of web data center products includes switches, server adapters, and software that are optimized to meet the specific challenges of managing web application trafficand provide high performance network infrastructure solutions.Alteo Websystems was founded in 1996 and is headquartered in San Jose, California.

Portfolio highlights

• Vectra AI — Vectra AI, the cybersecurity AI company that protects modern networks from modern attacks.
• Zebra Medical Vision — NANOX AI enables more accurate risk-adjustment so patients are provided with preventative care paths they need, while improving quality of health services at significantly lower associated costs.
• Blue River Technology — Blue River Technology is a pioneer in the use of computer vision and robotics for agriculture. Founded in 2011 by two Stanford University Alumni, Blue River Technology is bringing crop protection into the digital era with See & Spray machines that precisely observe and treat each plant in a field. By applying herbicides only to weeds thesemachines dramatically reduce the amount of chemicals used, enable farmers the freedom to choose any herbicide that meets their needs, and improve grower economics. Currently, farmers are limited to equipment that applies fertilizer and chemicals inefficiently across an entire field. In contrast, Blue River have developed tractor-towed robots that are able to sense each individual plant and precisely apply the right amount of inputs – all in real time, at tractor speeds.

Portfolio highlights

• Gusto — Gusto develops web-based payroll solution for small- and medium-sized businesses. It operates an online platform that provides payroll, benefits, human resources, and integration services for employers and employees in the United States.Gusto offers health benefits and workers’ compensation benefits that include medical insurance, commuterbenefits, and 401(k) contributions as well as workers’ compensation insurance plans, time tracking, and integration services, and access to employees for processing payroll from web-enabled devices such as smartphones and tablets. It also provides access to employees and contractors to browse their previous pay stubs, review their payroll forms, verify their personal details, and statistics about their pay, tax payments and federal forms filing services, and security and support services.Gusto serves startups, coffee shops, doctors, creative agencies, lawyers, and boutiques. Edward Kim, Joshua Reeves, and Tomer London founded ZenPayRoll in 2011 that became Gusto, with its headquarters in San Francisco in California with an additional office in Denver in Colorado.
• SolveAI —
• Smarterer — Individuals and Fortune 500 companies use Smarterer to help close the gap between the skills they have and the skills they need. Their dynamic assessment engine leverages the freshest crowdsourced tests around, to rapidly pinpoint skill level with a credible score. In November 2014, Pluralsight, the global leader in online learning for serioussoftware developers, IT specialists and creative technologists, acquired Smarterer. As the world's largest curated e-learning library for professionals, the company offers instant access to more than 3,500 courses authored by top experts. Smarterer will continue to power crowdsourced assessments for freelancer marketplaces, e-learning providers and enterprise companies anywhere people need to prove their skills to connect with professional opportunities. The Smarterer community has answered over 56 million during 1.7 million test sessions, across hundreds of tests.

Portfolio highlights

• Quadient Accounts Receivable by YayPay — YayPay accounts receivable automation software helps businesses collect faster, forecast cash flow accurately, and improve payment process. Automate your AR
• Sharper Sense — Neuromodulation for Clear Senses
• Willow Wealth — Willow Wealth is an alternative investment platform focused on generating income streams for investors. Get exclusive access to private market investments.

Portfolio highlights

• EvodiaBio — EvodiaBio is a bio-industrial firm that creates natural, sustainable scents for the food and beverage industries. Founded in 2021 and is based in Copenhagen, Capital Region.
• Nkarta Therapeutics — Nkarta seeks to improve upon the efficacy of cell therapy, making it more potent, better tolerated and more rapidly available to a broad population of patients with a variety of hematologic and solid tumor malignancies.While T-cell therapy, often known as CAR-T, has proven successful in certain cancer indications, its promise has been limited toa few hematologic malignancies and the side effects can be severe. Natural Killer cells are the immune system’s first responders against diseases and pathogens. Unlike T cells, they have an inherent ability to target tumor cells without genetic alteration, and therefore hold significant promise in the development of potent therapies that can be used more readily for diverse tumor types. Nkarta’s differentiated cell therapy approach is designed to boost and enhance the inherent power of Natural Killer cells to target and destroy tumor cells, while also offering a better tolerated safety profile.
• Kinaset Therapeutics — Kinaset Therapeutics is a therapeutics company that focuses on the advancement of novel drugs in areas of unmet medical needs. The company was founded in 2020 and is headquartered in Medfield, Massachusetts.

Portfolio highlights

• Skye Bioscience — Skye Bioscience is a pharmaceutical company providing new therapeutic outcomes for diseases with significant prevalence and unmet needs. It develops proprietary molecules to treat diseases involving inflammatory, fibrotic, and metabolic conditions.
• Enliven Therapeutics — Enliven Therapeutics is a precision oncology company developing small molecule therapies to extend and improve patient lives.The company's discovery process combines clinically validated biological targets and industry-leading chemistry to address the limitations of existing therapies. This approach allows us to efficiently and effectivelydevelop precision oncology therapeutics that enhance overall patient well-being.Founded in July 2019 by Sam Kintz, MBA, Joe Lyssikatos, PhD, and Anish Patel, PharmD, Enliven Therapeutics is based in Boulder, Colorado.
• Magnetic Insight — Magnetic Insight (MI) introduced magnetic particle imaging into the preclinical diagnostic research market enabling quantitative cell tracking, imaging of vascular function, detecting metastatic tumors, visualizing inflammation, CAR-T cell therapies and initial research into regenerative medicine.

Portfolio highlights

• Sironax — Sironax is a pharmaceuticals company for inflammatory and neuro-degenerative diseases.
• Axle Health — Axle Health provides scheduling and workforce management software to help home healthcare and hospice providers improve their clinician productivity.
• Mersana Therapeutics — Discover how Day One is disrupting the status quo of traditional drug development to bring new medicines to children and adults with cancer.

Portfolio highlights

• HerdDogg — HerdDogg is a global herd health and data science platform. It is a two-part system that helps ranchers track health and proximity data from their herd. The company's device gathers the data captured by the ear tags and reports it directly to the rancher via an app or web database.
• Insignum AgTech — Insignum AgTech develops biotech plants that communicate with producers, alerting them to an illness in its early stages.
• Rescue Forensics — Customer service is our #1 priority. Get a premium domain for your website today. Financing available.

Portfolio highlights

• Orna Therapeutics — Orna Therapeutics is a biotechnology company dedicated to designing and delivering a new class of fully engineered circular RNA (oRNA) therapeutics with the potential to change the way we treat disease. Orna’s proprietary platform combines novel technology to create oRNAs that drive protein expression with validated and unique delivery solutions.
• Aratana Therapeutics — Aratana is uniquely positioned to deliver new, high-quality medicines to address unmet needs in companion animal care. We are committed to bringing world class science to animal health for companion animals and the people who care for them. Our competitive advantage resides in our ability to identify, acquire and develop high-value commercialproducts for companion animals in a cost effective and efficient manner.
• Rhythm Pharmaceuticals — Rhythm Pharmaceuticals is a global biopharmaceutical company committed to transforming the lives of patients with rare neuroendocrine diseases by rapidly advancing care and precision medicines that address the root cause.

Portfolio highlights

• Mux — Mux helps teams ship high-performance and cost-effective video in minutes, not months. Build better video into anything from websites to platforms to AI workflows.
• Slack — Slack is a cloud-based communication and collaboration platform for teams. It allows users to exchange messages, share files, and integrate with various business tools and services. Slack is commonly used across various industries, from tech startups to large enterprises.
• Bigscreen — Founded by Darshan Shankar in 2014, Bigscreen is a venture-backed startup creating an immersive virtual reality platform that aims to revolutionize the way people work, play, hangout, and collaborate.Use cases of Bigscreen include both entertainment and productivity. Users love using Bigscreen as a "VR movie theater" to watch movies andTV shows. It's also used to play videogames, browse the web, and hangout with friends. It's can also be used for productivity as a tool for remote teams to collaborate together in virtual offices.Since the beta launch in March 2016, Bigscreen has become one of the most popular and highest rated VR apps on the Oculus Store and has an incredible 93% positive rating on Steam. Power users spend 20-30 hours per week in Bigscreen, making it one of the most widely used "killer apps" in the industry.Bigscreen is now the most popular non-gaming VR application in the world.Bigscreen is a fully distributed remote company with employees based around the world in the US & UK.

Portfolio highlights

• withco — Rebuilding main street, one share at a time.
• Journey Live — Journey is shifting the way modern companies prioritize mental health. Our proactive, inclusive tools engage every employee, every day.
• GroundWork — GroundWork delivers Unified Monitoring for Real™ with an open software platform for shockingly easy integrations and customized visualizations of cloud, virtualization, network, application, server, and storage data.GroundWork Monitor is available in free (Core) and subscription versions with support (Enterprise).GroundWork was founded in 2004 andis headquartered in San Francisco, California with partners in Asia Pacific, Europe and South America.

Portfolio highlights

• Immune Design — Immune Design Corp. (IDC) uses breakthrough technology to develop safe and effective vaccines and therapeutics, with emphasis on the prevention and treatment of infectious disease. This goal is being achieved through dedicated research aimed towards a greater understanding of the immune system, and by developing a new generation of immune-basedproducts for the pharmaceutical industry. IDC is passionate about its mission to alleviate human suffering and pursues this goal with high energy and an unsurpassed standard of excellence
• Carmot Therapeutics — Breakthrough science. One moment, one day, one person at a time.
• Constellation Pharmaceuticals — Constellation Pharmaceuticals is the first biopharmaceutical company dedicated to the development of novel therapeutics in the emerging field of Epigenetics, a new field of science which is focused on selective regulators of epigenetic function, which are critical to controlling gene expression.

Portfolio highlights

• Toonimo — Toonimo humanize the web user experience with an engaging and personalized step-by-step interactive walkthrough
• Kyruus Health — Kyruus Health is the leading care access platform on a mission to connect people to the right care.
• Cajal Neuroscience — Cajal Neuroscience is a drug discovery company focused on neurodegenerative disease.

Portfolio highlights

• Zag Bio — Zag Bio is harnessing the immune system in a whole new way by targeting the thymus to change treatment possibilities for millions of patients with autoimmune diseases.
• Skeletalis — Skeletalis is a biotechnology startup focused on developing next-generation precision medicines for musculoskeletal diseases, primarily osteoporosis.
• Tacit Therapeutics — New broadly-applicable and non-immunogenic RNA gene therapy that can treat thousands of devastating illnesses.

Portfolio highlights

• Gridware — Using remote telemetry and edge AI, Gridware wildfire prevention technology powers a grid that is smarter and more reliable than ever before.
• Onepot.ai — Search 2.7 billion make-on-demand analogs from onepot CORE, get a quote, and we synthesize and QC them in our US-based lab. AI-powered custom synthesis CRO.
• Adaption Labs — Adaptation creates AI systems that adjust to changing real-world circumstances.

Portfolio highlights

• Latus Bio — Latus Bio focuses on developing innovative gene therapy candidates using precision delivery to enhance the lives of patients. Latus identified proprietary AAV capsids for clinical use. The company plans to administer low doses of its product candidates, aiming to improve clinical safety and manufacturing.
• Overwatch Health — Overwatch Health offers an AI-assisted virtual rehab for cardiac and pulmonary patients.
• Palvella Therapeutics — Palvella Therapeutics is committed to developing safe and effective therapies that specifically target the root cause of genetic skin diseases.

Portfolio highlights

• eBrevia — Analyze contracts at scale, extract key data, and identify risk with eBrevia. Draft and redline agreements in Microsoft Word with DraftPro.
• Mobile Sense — The traditional diagnostic market is being transformed by advances in high performance wearables. This seismic shift led by consumer products which are uncovering new patients who previously went undetected, but still require a detailed diagnosis. Mobile Sense™ is building foundational technology that enables this transformation throughoff-the-chest wearables for long term management of cardiac arrhythmias. Developed over 7 years with $4.2M in grant funding and $1.3M in seed funding, Mobile Sense™ has a platform for differentiated wearables. Our embedded algorithms coupled with non-adhesive, wireless & waterproof sensors provides high fidelity continuous ECG and PPG recordings. The automatic monitoring provides 24/7, 365 days/yr continuous detection and classification of dangerous heart arrhythmias.
• LegiTime Technologies — LegiTime Technologies, Inc. provides LegiText, a subscription-based SMS solution that offers message authentication, categorization, and archiving based on demonstration of legitimacy technology. It also provides LegiTrac that locates and tracks devices, as well as back up and stores data in a central location; and LegiAlert that offers messagebroadcasts and alerts, creates groups and contact lists, and integrates contact information with existing back office data systems. The company serves enterprises and educational institutions, as well as consumer, finance and banking, and healthcare industries. LegiTime Technologies, Inc. was founded in 2005 and is based in Farmington, Connecticut.

Portfolio highlights

• Deck Bio — Deck Bio develops T cell engagers that recognize multiple cancer signals, expanding the reach of immunotherapy to treat tumors that other therapies miss.
• EpiBiologics — EpiBiologics develops first-in-class antibody based targeted therapies against membrane and extracellular proteins that drive underlying disease biology.
• Beech Biotech — Beech Biotech is utilizing cutting-edge biology to develop innovative therapies for preeclampsia and other pregnancy-related issues. This business extends pregnancy and lessens the effects of premature birth.

Portfolio highlights

• Bionano Genomics — Discover how Bionano is striving to elevate health and wellness for all through optical genome mapping (OGM) solutions that transform the way the world sees the genome.
• Protego Biopharma — Protego Biopharma develops therapeutics based on the clear human genetic link, excellent human safety profile, proof-of-principle efficacy. The company was founded in 2011 and is headquartered in San Diego, California.
• Twentyeight-Seven Therapeutics — Maxslot88 merupakan link situs slot gacor gampang menang jackpot maxwin hari ini sebagai daftar apk slot88 terpercaya dengan server thailand resmi, memberikan pengalaman bermain slot online yang aman dan menghibur bagi semua klien.

Portfolio highlights

• Ascidian Therapeutics — Ascidian Therapeutics is a biotechnology company intended for medical use in medical and clinical gene therapy.
• Red Queen Therapeutics — Staying ahead of viral threats with new innovations in antiviral therapy
• Deep Apple Therapeutics — Deep Apple Therapeutics is discovering new small-molecule therapeutics with unprecedented speed and exceptional acumen.

Portfolio highlights

• Culture Biosciences — Culture Biosciences provides a platform of cloud-connected bioreactors, software tools, and process development services that support upstream bioprocess development for biotech and biopharma applications. The company’s offerings include remote experiment design, monitoring, and data analysis through an integrated cloud software interface pairedwith single-use bioreactors for microbial fermentation and cell culture experimentation. Its services encompass clone and strain screening, process optimization, characterization, and bioprocess modeling to help scientific teams refine and scale their workflows. Clients access real-time data and analytics to inform decisions and collaborate across teams using the platform’s tools. Culture Biosciences’s technology is used to advance development of therapeutics, synthetic biology products, and related bioprocesses. Culture Biosciences was founded in 2016 and is headquartered in San Francisco, California.
• Mestag Therapeutics — Driving fibroblast-immune conversations in cancer and inflammatory diseases.
• EnPlusOne Biosciences — EnPlusOne Biosciences provides innovative solutions for emerging RNA therapeutics.

Portfolio highlights

• Sabanto — Sabanto brings autonomy to agriculture with retrofit kits that transform existing tractors into fully autonomous machines. Boost efficiency, reduce labor, and farm 24/7 with the Sabanto Autonomy System. Book a demo today.
• CH4 Global — CH4 Global is an aquaculture solutions provider dedicated to urgently impacting climate change at scale. Lead by a world-class team of senior business builders, scientists and entrepreneurs, the company is initially leveraging proven science and technology for growing seaweed into innovative new livestock supplement that reduces methane produced bycows by up to 90%. Among early investors are a select group of prominent family offices and private investors. CH4 Global have also received non-dilutive capital support from government organizations from around the world. CH4 Global is a Delaware corporation based in Henderson, NV.
• Tradeshift — Tradeshift is a supply chain network, Tradeshift is a market leader in e-invoicing and accounts payable automation and an innovator in supplier financing and B2B marketplaces.

Portfolio highlights

• Exciva — EXCIVA GmbH is a privately held biotech company focused on development of clinical stage therapeutics for various indications in neuropsychiatry.
• Transition Metal Solutions — Transition harnesses wild microbial communities to recover copper and other critical metals from low-grade mining resources.
• MindImmune Therapeutics — Breaking through barriers to new therapeutics for brain disease.

Portfolio highlights

• Ixchelsis — Ixchelsis Ltd is a clinical-stage biotechnology company developing an oxytocin receptor antagonist (IX-01) for the treatment of premature ejaculation (PE). IX-01 is a clinical stage asset that has the potential to be the best in class pharmacological approach for the treatment of PE. To date IX-01 has completed a Phase 1 single ascending dose studyin healthy male volunteers and is currently being progressed through to clinical proof of concept (POC). Ixchelsis is funded by TVM Life Sciences Ventures VII and is lead by an excellent Management team with extensive experience in pharmaceutical R&D, particularly in the male sexual health therapeutic area.
• Flare Therapeutics — Flare Therapeutics is a biotechnology company opening up a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders, Flare’s team has uncovered ‘switch sites,’ druggable regions that are key targets fortranscription factor regulation to address mutations that cause disease. Its drug discovery to target switch sites has rapidly advanced, resulting in an emerging pipeline of drug programs that address well-validated transcription factors, initially focused on precision oncology with future potential in neurology, rare genetic disorders, immunology, and inflammation.
• Flexion Therapeutics — Flexion Therapeutics advances drug candidates through clinical proof of concept and beyond, in partnership with pharmaceutical and biotechnology companies. By providing expertise and sharing risk, Flexion effectively expands the portfolios of its partners.

Portfolio highlights

• Tarveda Therapeutics — Developing Pentarins to make a difference in the treatment of patients with solid tumor malignancies
• Tarsa Therapeutics — Tarsa Therapeutics is developing an oral formulation of calcitonin, a peptide hormone for the treatment of osteoporosis that slows the rate of bone destruction.
• Nkarta Therapeutics — Nkarta seeks to improve upon the efficacy of cell therapy, making it more potent, better tolerated and more rapidly available to a broad population of patients with a variety of hematologic and solid tumor malignancies.While T-cell therapy, often known as CAR-T, has proven successful in certain cancer indications, its promise has been limited toa few hematologic malignancies and the side effects can be severe. Natural Killer cells are the immune system’s first responders against diseases and pathogens. Unlike T cells, they have an inherent ability to target tumor cells without genetic alteration, and therefore hold significant promise in the development of potent therapies that can be used more readily for diverse tumor types. Nkarta’s differentiated cell therapy approach is designed to boost and enhance the inherent power of Natural Killer cells to target and destroy tumor cells, while also offering a better tolerated safety profile.

Portfolio highlights

• Attenua — 100% satisfaction guaranteed. Hassle-free shopping. We help you find the right domain name.
• Andrew Alliance — OneLab is laboratory software to design and execute liquid handling protocols. Pipette+ for manual liquid handling pipetting and Andrew+ the pipetting robot
• Chord Therapeutics — Chord Therapeutics is a clinical stage pharmaceutical company developing drugs for patients with rare, life-threatening and severely disabling diseases. We are advancing our lead drug candidate CRD1 under orphan drug designation for the treatment of neuromyelitis optica spectrum disorders (NMOSD) and myasthenia gravis (MG).

Portfolio highlights

• Ribometrix — The Next Frontier of Drug Discovery
• G1 Therapeutics — G1 Therapeutics is a clinical-stage company developing novel cancer therapies. It was founded in 2008 by Drs. Norman Sharpless and Kwok-Kin Wong to capitalize on discoveries made and patented by Dr. Sharpless’ lab at the University of North Carolina at Chapel Hill, and subsequently licensed to G1 Therapeutics. Trilaciclib is an investigationaltherapy designed to improve outcomes for people with cancer who are treated with chemotherapy. G1 is also advancing rintodestrant, a potential best-in-class oral selective estrogen receptor degrader, or SERD, for the treatment of ER+ breast cancer.
• Viamet Pharmaceuticals — Viamet Pharmaceuticals discovers and develops "best-in-class" inhibitors of validated metalloenzymes via an innovative and proprietary metal-binding approach, their Metallophileâ„¢ Technology. Viamet's disruptive Metallophileâ„¢ technology is based on their world-class expertise in bioinorganic chemistry and metalloenzymes and allowsthem to identify validated targets with high therapeutic and commercial potential; leverage existing metalloenzyme inhibitors as the basis for Viamet's best-in-class analogs; and rapidly and cost-effectively generate best-in-class, patentable, small molecule compounds by optimizing the metal-binding component of existing inhibitors.

Portfolio highlights

• Expedition Medicines — Defining a new era in drug discovery where chemistry rewrites the rules of biology to engage any protein target.
• Foghorn Therapeutics — Foghorn Therapeutics is developing therapies based on a system that directs which genes our cells express, and when, where, and in what order.By manipulating this system with our unique Gene Traffic ControlTM platform, Foghorn will change how genes turn “on” and “off.” Unlike approaches that edit genes, this novel way of thinking will alter whatour DNA has in store for us—and rewrite destiny for millions of people living with disease.With Gene Traffic ControlTM Foghorn is pioneering a new, major class of drug targets to develop unprecedented therapies for cancer and other serious diseases. We have already validated multiple targets, are in the process of developing drug candidates in multiple types of cancer and are beginning to explore other diseases.
• Serif Bio­med­i­cines — Serif Biomedicines is pioneering Modified DNA as a new type of biotechnology. Serif combines nucleic acid chemistry, synthetic biology, delivery technology, and artificial intelligence to develop programmable, scalable, long-lasting, and redosable DNA therapies.

Portfolio highlights

• Cebix — Cebix is focused on the development of chronic replacement therapy based on human proinsulin C-peptide for the treatment of type 1 diabetic neuropathy. The role of C-peptide will also be explored in type 1 diabetic nephropathy and retinopathy.
• Merus — Merus is a biotechnology company that discovers and develops new treatments for cancer patients. The company utilizes its proprietary Multiclonics Platform technology to advance its clinical pipeline of medicines. Merus conducts scientific research and clinical trials focused on developing novel treatments.
• Dauntless Pharmaceuticals — Dauntless Pharmaceuticals is a therapeutics company that focuses on the development of drugs. The traditional biotech company holds numerous assets at various stages of development, and its investors, management, labs, and staff collectively share an interest in all company assets. It was founded in 2015 and headquartered in San Diego,California.

Portfolio highlights

• OxCan — Enabling curative cancer treatment through early detection
• Foresight Diagnostics — We develop innovative diagnostics to advance decision-making in oncology drug development and patient care.
• Rinascera Therapeutics — Rinascera Therapeutics develops transformative therapies for rare genetic skin diseases, including RIN-001 for Gorlin Syndrome and RIN-002 for Dystrophic Epidermolysis Bullosa (DEB).

Portfolio highlights

• Simpata — Simpata Inc is a software company that provides its clients with internet-based application services of employee human resources.
• Zeltiq Aesthetics — Learn about the CoolSculpting cryolipolysis procedure.
• Iolyx Therapeutics — Iolyx Therapeutics is a biotechnology research and healthcare service provider for ocular diseases.

Portfolio highlights

• Datalogix — Datalogix® is the industry-recognized leader at connecting digital media and offline purchasing data. We help more than half of the top 100 consumer marketers increase the effectiveness and measurability of their advertising. DLX Platform®, encompasses over $1 trillion in consumer spending and powers campaigns for more than 75% of online mediacompanies. DLX ROI® is rapidly becoming the industry standard for measuring offline sales lift for digital media. Datalogix also offers predictive analytics for Direct Mail, and integrated media solutions via the DLX Net. Our expertise spans the major consumer segments, including Retail, CPG, Automotive, Telecom, Travel and Financial Services. We are based in Colorado, with offices in New York City, San Francisco, Boston, Chicago, Detroit, and London.
• Legora — By streamlining and simplifying legal workflows, we empower elite law firms and legal professionals to work more efficiently and effectively. Enabling them to focus on higher-value tasks and deliver exceptional results for their clients.
• Ramp — Join thousands of forward-thinking businesses using Ramp to control spend, save time, and automate busywork.

Portfolio highlights

• Modumetal — Modumetal has enabled a revolutionary new class of nanolaminated materials with broad application in structural, corrosion and high temperature performance of coatings, bulk materials and partsModumetal is based on the interaction of different materials at their interfaces. By laminating metals, Modumetal creates a new way to influence materialproperties. By growing metal using low-cost electrochemical methods, Modumetal enables a whole new class of applications of these materials.Modumetal is currently producing nanolaminated alloys for applications in construction, energy and aerospace markets.
• Quantcast — We are taking an entirely new approach to advertising on the open internet.
• Numeric — Hundreds of teams streamline reconciliations, organize their close, and leverage AI for flux analysis and reporting with Numeric.

Portfolio highlights

• ATDev — ATDev builds robotic mobility and assistive technology for elderly and disabled people, from the RAMMP mobility platform to the Reflex rehab knee brace.
• Journey Live — Journey is shifting the way modern companies prioritize mental health. Our proactive, inclusive tools engage every employee, every day.
• Trio Pharmaceuticals — Trio Pharmaceuticals is a cancer therapeutics company that develops dual-action drugs for immunogenic tumors. These drugs directly stop tumor growth and selectively stop immunosuppression in the tumor without targeting the current immune checkpoint pathways. The company was founded in 2018 and is headquartered in San Diego, California.

Portfolio highlights

• EnClear Therapies — EnClear Therapies is a Cambridge (USA) based life sciences company developing a device-based therapy to aid in the treatment of neurodegenerative disease and delivery and monitoring of cerebrospinal fluid (CSF). EnClear’s proprietary therapeutic platform focuses on removing toxic proteins from the CSF. The company’s first products will targetimproving the lives of patients with Amyotrophic Lateral Sclerosis (ALS) and Progressive Supranuclear Palsy (PSP).
• Ember LifeSciences — Ember LifeSciences is a healthcare technology company that develops cold chain solutions to support the safe transport of temperature-sensitive medicines, vaccines, and biologics using proprietary temperature control systems. The company’s core offering includes the Ember Cube. This self-refrigerated and cloud-connected shipping container providescontinuous temperature monitoring, GPS tracking, and real-time data reporting to maintain drug efficacy during transit. Ember LifeSciences leverages its engineering expertise in thermal management and digital monitoring to develop modular shipping solutions that can replace traditional single-use cold chain packaging, thereby reducing waste. It works with pharmaceutical distributors, specialty pharmacies, and laboratories by enabling visibility and control over critical environmental conditions throughout distribution. The company continues to develop next-generation versions of its devices, incorporating improved insulation and configurable features to support broader supply chain use cases.
• Mindset Medical — Medical Mindset is your health companion. It is a platform for you to track your health and wellness.

Portfolio highlights

• Somatix — A fully comprehensive monitoring solution with unique smartband technology. Solutions for SNFs, senior living, healthcare systems, and smoking cessation.
• Girihlet — Girihlet is a provider of rapid and accurate deep sequencing services with a unique focus on developing novel technologies. Girihlet currently specializes in inexpensively sequencing and analyzing mtDNA and T cell receptors using novel, bias-free methods in order to harness their power as biomarkers for diagnostics in a variety of disorders.
• Omni — Omni provides Healthy Vegan Dog Food in the UK, made by vets to be a nutritionally complete meal for your dog. Feed your dog all the goodness of plants backed by science.

Portfolio highlights

• Normunity — We create medicines that free normal immunity to defeat cancer using proprietary platforms that uncover novel immuno-oncology mechanisms.
• Gossamer Bio — Gossamer Bio is a San Diego-based company focused on the discovery and development of novel and differentiated therapeutic products, to address high unmet needs amongst various targeted patient populations. Founded by the former Receptos executive team, Gossamer Bio’s strategy will be to leverage an asset-rich in-licensing environment, with a focuson areas of high unmet need, utilizing a team with a strong track record of execution in immunology, inflammation, fibrosis and oncology.
• Graphite Bio — Graphite Bio is a next-generation gene editing company focused on therapies that harness targeted gene integration to treat or cure serious diseases

Portfolio highlights

• Pila Energy — Energy Independence for Everyone.
• The Biological Computing — Biological Black Box integrates biological neurons with artificial neural networks to develop a living computer.
• Berkeley Yeast — Better yeast for better beer. Make cleaner tasting beer with ultra low diacetyl strains, brew non alcoholic beer that tastes more like actual beer, or unlock bright grapefruit and passionfruit notes with the cleanest thiol yeast.

Portfolio highlights

• Gelmedix — Gelmedix is a developer of a biomaterial platform to improve drug delivery for complicated ophthalmic treatment. The company's platform offers a single non-invasive gel patch that can be used as a drug-eluting sealant with tissue adhesion, tunable drug elution, and biocompatibility properties, thereby enabling healthcare providers to reducethe usage of drops which cause inconvenience to patients.
• Zylö Therapeutics — Patented technology that enables, for topicals, sustained release, increased druggability, a Patchless Patch concept, and enhanced targeting of pores and follicles
• Astrocyte Pharmaceuticals — Astrocyte Pharmaceuticals Inc. is a privately held drug development company dedicated to accelerating the recovery and well-being of brain injury patients. The company is committed to proving the neuroprotective benefits of selective astrocyte activation, and advancing breakthrough therapeutic agents for treating brain injury resulting from stroke,TBI, concussion, and neurodegenerative disorders such as Alzheimer’s disease.

Portfolio highlights

• Saronic — Providing the most advanced and capable autonomous vessels in the maritime domain.
• Ushur — Ushur is a cloud-based automation platform that automates service workflows in both the backend process and conversational interfaces.The company develops intelligent automation solutions that include, Ushur Virtual Customer Assistant, smart technology that automates proactive member, claimant, agent, or broker communications across virtually anychannel, reaching out to customers, understanding what they need, and automatically taking the next steps; Ushur SmartMail, a software that allows insurers to process high-volumes of the customer, agent and broker email automatically, allowing carriers to respond faster and efficiently; Ushur Flowbuilder, the web-based no-code builder allows claims, broker services, and customer support teams to build, deploy and track rich digital engagements that improve business agility and the customer experience while minimizing the burden on IT. By leveraging the company's Robotic Process Automation (RPA) and Language Intelligence Service Architecture (LISA), insurance companies can accelerating capital and time-intensive processes like claims, customer support, billing, and enrollment to digitally transform service workflows.
• Flywheel.io — Flywheel is a data management and analysis platform built specifically for scientists and the researcher's workflow. They empower research momentum by focusing on data and medical image capture, content management, scientific computation, and collaboration. With reproducible research in mind, they combine open-source methods from topuniversities, a modern web user interface, and an extensible compute engine based on containerization technology. The result is a software platform to accelerate discovery and help researchers do science, not IT.Flywheel accelerates new scientific discoveries in life-science, biotech, and academic imaging research through cloud-scale collaboration. As a result, imaging researchers are able to avoid innovation bottlenecks, and accelerate discovery by doing more science, and less IT.

Portfolio highlights

• Adlai Nortye — Adlai Nortye is a global clinical-stage biopharmaceutical company focused on innovative oncology drugs, with its R&D and global clinical operation centers in both China and the United States. With a strategic emphasis on oncology, it has built a global pipeline through collaborations and internal discoveries with more than 10 drug candidates indevelopment.
• City Therapeutics — Leading the next-generation of RNAi trigger molecule engineering to develop a pipeline of disruptive medicines.
• Flare Therapeutics — Flare Therapeutics is a biotechnology company opening up a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders, Flare’s team has uncovered ‘switch sites,’ druggable regions that are key targets fortranscription factor regulation to address mutations that cause disease. Its drug discovery to target switch sites has rapidly advanced, resulting in an emerging pipeline of drug programs that address well-validated transcription factors, initially focused on precision oncology with future potential in neurology, rare genetic disorders, immunology, and inflammation.