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Top 50 Biotechnology VC Funds & Investors in United States (September 2026)

The most active venture capital funds investing in United States Biotechnology startups. This investor list is updated monthly from the Shizune investor database, ranked by number of investments in United States Biotechnology startup companies. Find investors to raise a Seed, Series A or Series B round with Shizune.
Investor Relevant Deals Geography Stage Focus Round Size
ARCH Venture Partners
VC Fund
159 United States, China, United Kingdom Series A, Series B, Series C Biotechnology, Health Care, Therapeutics $8.4M–$230M
Alexandria Venture Investments
VC Fund
128 United States, Canada, France Series A, Series B, Seed Biotechnology, Health Care, Therapeutics $2M–$150M
SOSV
VC Fund
124 United States, India, United Kingdom Seed, Convertible Note, Pre-Seed Biotechnology, Health Care, Software
Alumni Ventures
VC Fund
113 United States, United Kingdom, Canada Seed, Series A, Series B Software, Artificial Intelligence, Information Technology $850k–$75M
OrbiMed
VC Fund
107 United States, China, Israel Series B, Series A, Series C Biotechnology, Health Care, Medical $9.8M–$160M
Atlas Venture
VC Fund
94 United States, United Kingdom, Canada Series A, Series B, Series C Biotechnology, Health Care, Therapeutics $3.6M–$115M
Google Ventures
VC Fund
92 United States, United Kingdom, Israel Series A, Series B, Seed Software, Health Care, Biotechnology $1.2M–$121M
Khosla Ventures
VC Fund
90 United States, India, United Kingdom Series A, Series B, Seed Software, Artificial Intelligence, Health Care $1.9M–$100M
New Enterprise Associates
VC Fund
86 United States, India, United Kingdom Series A, Series B, Series C Software, Health Care, Biotechnology $6M–$103M
RA Capital Management
VC Fund
84 United States, United Kingdom, Canada Series B, Series C, Post-IPO Equity Biotechnology, Health Care, Therapeutics $27M–$275M
Polaris Partners
VC Fund
83 United States, Ireland, Singapore Series B, Series A, Series C Biotechnology, Health Care, Medical $4.6M–$107M
Gaingels
VC Fund
79 United States, Canada, Mexico Seed, Series A, Series B Software, Health Care, Artificial Intelligence $1M–$100M
Third Rock Ventures
VC Fund
78 United States Series A, Series B, Series C Biotechnology, Health Care, Therapeutics $11M–$190M
Versant Ventures
VC Fund
76 United States, Switzerland, Canada Series A, Series B, Series C Biotechnology, Health Care, Medical $5M–$108M
F-Prime
VC Fund
75 United States, United Kingdom, China Series A, Series B, Series C Health Care, Biotechnology, Medical $9.2M–$150M
Andreessen Horowitz
VC Fund
68 United States, United Kingdom, Brazil Series A, Seed, Series B Software, Information Technology, Artificial Intelligence $1.6M–$112M
5AM Ventures
VC Fund
67 United States, Switzerland, United Kingdom Series A, Series B, Series C Biotechnology, Health Care, Therapeutics $13M–$110M
MPM Capital
VC Fund
67 United States, Canada, United Kingdom Series B, Series A, Series C Biotechnology, Health Care, Therapeutics $10M–$116M
Innova Memphis
VC Fund
66 United States, Germany, Argentina Seed, Pre-Seed, Convertible Note Health Care, Medical, Medical Device $25k–$1.5M
Fifty Years
VC Fund
62 United States, Germany, Canada Seed, Series A, Pre-Seed Biotechnology, Health Care, Artificial Intelligence $572k–$40M
Canaan Partners
VC Fund
60 United States, United Kingdom, Israel Series A, Series B, Series C Software, Biotechnology, Health Care $5.5M–$75M
Liquid 2 Ventures
VC Fund
54 United States, Mexico, Canada Seed, Series A, Pre-Seed Software, Artificial Intelligence, Information Technology $125k–$48M
Lux Capital
VC Fund
53 United States, United Kingdom, Canada Series A, Seed, Series B Software, Artificial Intelligence, Health Care $1.8M–$150M
The Column Group
VC Fund
53 United States Series A, Series B, Series C Biotechnology, Health Care, Therapeutics $15M–$120M
DCVC
VC Fund
52 United States, Canada, United Kingdom Seed, Series A, Series B Software, Artificial Intelligence, Machine Learning $1.1M–$130M
BioAdvance
VC Fund
50 United States, Canada Seed, Series A Biotechnology, Health Care, Medical $350k–$40M
KdT Ventures
VC Fund
50 United States, India, Canada Seed, Series A, Series B Biotechnology, Health Care, Medical $2.6M–$175M
Apple Tree Partners
VC Fund
49 United States, Canada, United Kingdom Series A, Series B, Seed Biotechnology, Health Care, Therapeutics $3.5M–$100M
8VC
VC Fund
48 United States, United Kingdom, Canada Series A, Seed, Series B Software, Health Care, Artificial Intelligence $2.5M–$175M
Connecticut Innovations
VC Fund
48 United States, Israel, Canada Seed, Series A Health Care, Biotechnology, Software $150k–$25M
TCA Venture Group
VC Fund
45 United States, Canada, South Africa Seed, Convertible Note, Venture - Series Unknown Health Care, Software, Biotechnology $50k–$8.5M
Pfizer Venture Investments
VC Fund
45 United States, United Kingdom, Switzerland Series B, Series A, Series C Biotechnology, Health Care, Therapeutics $10M–$120M
Omega Funds
VC Fund
45 United States, Switzerland, United Kingdom Series A, Series B, Series C Biotechnology, Health Care, Therapeutics $14M–$208M
Sand Hill Angels
VC Fund
45 United States, Canada, India Seed, Convertible Note, Series A Software, Health Care, Biotechnology $300k–$25M
Deerfield
VC Fund
44 United States, United Kingdom, Canada Series A, Series C, Series B Health Care, Biotechnology, Medical $11M–$114M
Mission BioCapital
VC Fund
44 United States, Switzerland, France Series A, Series B, Venture - Series Unknown Biotechnology, Health Care, Therapeutics $2M–$112M
Novartis Venture Fund
VC Fund
44 United States, Switzerland, United Kingdom Series B, Series A, Series C Biotechnology, Health Care, Therapeutics $5.1M–$120M
Dolby Family Ventures
VC Fund
44 United States, Austria, Germany Series A, Seed, Series B Biotechnology, Health Care, Software $2M–$65M
Founders Fund
VC Fund
44 United States, United Kingdom, Germany Series A, Seed, Series B Software, Health Care, Information Technology $1.7M–$100M
Hatteras Venture Partners
VC Fund
43 United States, Canada Series A, Series B, Series C Health Care, Biotechnology, Medical $2.6M–$88M
Casdin Capital
VC Fund
43 United States, China, France Series B, Series A, Series C Biotechnology, Health Care, Therapeutics $10M–$191M
Lightspeed Venture Partners
VC Fund
42 United States, India, Israel Series A, Series B, Seed Software, Information Technology, Artificial Intelligence $2M–$125M
Life Science Angels
VC Fund
42 United States, Israel, The Netherlands Seed, Series A Biotechnology, Health Care, Medical $1M–$10M
Refactor
VC Fund
42 United States, United Kingdom, New Zealand Seed, Series A, Series B Health Care, Biotechnology, Medical $2.5M–$103M
Northpond Ventures
VC Fund
41 United States, United Kingdom, Canada Series A, Series B, Series C Biotechnology, Health Care, Life Science $13M–$95M
Novo Holdings
VC Fund
41 United States, Denmark, United Kingdom Series A, Series B, Series C Biotechnology, Health Care, Medical $9.5M–$135M
General Catalyst
VC Fund
41 United States, United Kingdom, India Series A, Seed, Series B Software, Artificial Intelligence, Health Care $1.7M–$123M
Flagship Pioneering
VC Fund
41 United States, Canada, United Kingdom Series B, Series C, Series A Biotechnology, Health Care, Medical $6.5M–$230M
Frazier Healthcare Partners
VC Fund
40 United States, Canada, Ireland Series B, Series A, Post-IPO Equity Biotechnology, Health Care, Therapeutics $10M–$200M
Foresite Capital
VC Fund
40 United States, United Kingdom, China Series B, Series C, Series A Biotechnology, Health Care, Therapeutics $17M–$270M
Access all 9202 VC funds in United States Biotechnology startups.

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822 industries, 177 countries. Updated daily. Emails and phones included.

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Investor list

ARCH Venture Partners
VC Fund · Chicago, Illinois, United States · 159 investments in United States Biotechnology startups

ARCH Venture Partners provides seed / early stage venture capital for technology firms in information technology, life sciences, and physical sciences

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series A, Series B, Series C
  • Geography: United States, China, United Kingdom

Investor stats

  • Total investments: 466
  • Round size: Series A $8.4M–$216M; Series B $14M–$230M; Series C $15M–$167M
  • Lead/follow: 32% lead, 68% follow
  • Last fund: Likely actively investing — fresh fund, raised $3B in 2024

Portfolio highlights

  • Synchron — The endovascular brain computer interface.
  • Parabilis Medicines — Parabilis Medicines is a biopharmaceutical company in the clinical stage that focuses on developing exceptional medications targeting challenging protein structures previously deemed undruggable. Utilizing more than ten years of exclusive data, innovative laboratory techniques, and algorithms based on AI and physics, the company has introduced anovel category of stabilized, cell-penetrating alpha-helical peptides known as Helicons™. These peptides can modulate intracellular proteins that traditional drug modalities cannot reach.
  • Moonwalk Biosciences — By deeply profiling and targeting the epigenetic code, Moonwalk aims to reprogram cells to their healthy state, fundamentally enabling a new approach to how therapies are discovered and developed.
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Alexandria Venture Investments
VC Fund · Pasadena, California, United States · 128 investments in United States Biotechnology startups, 18 in the past 12 months

Alexandria Venture Investments is a venture capital firm that develops work in real estate technology, and healthcare sectors. The company's strategic venture capital platform is Alexandria Venture Investments. Since its inception in 1996, the company has invested in disruptive life science, agrifood tech, and technology companies that aredeveloping transformative new modalities and platforms to meaningfully improve human health.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series A, Series B, Seed
  • Geography: United States, Canada, France

Investor stats

  • Total investments: 297
  • Round size: Seed $2M–$30M; Series A $12M–$100M; Series B $25M–$150M
  • Lead/follow: 8% lead, 92% follow

Portfolio highlights

  • Leal Therapeutics — Leal Therapeutics develops novel therapeutics for patients.
  • Vedana Therapeutics — Vedana Therapeutics is a Seattle biotechnology company developing next-generation antibody therapies for migraine prevention.
  • Khartis Therapeutics — Khartis is a drug discovery company developing oral therapies for patients with immune-mediated and chronic diseases. The company focuses on discovering and developing drug candidates intended to address chronic conditions and immune-mediated diseases.
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SOSV
VC Fund · Princeton, New Jersey, United States · 124 investments in United States Biotechnology startups, 75 in the past 12 months

SOSV is a global, deep tech venture capital firm that operates the HAX and IndieBio startup development programs focused on human and planetary health. SOSV invests $500,000 in startups at their inception as they onboard either HAX or IndieBio for a 4-6 month period designed to accelerate the raise of their next institutional round. SOSV joins thelater rounds of HAX and IndieBio graduates. HAX, based in a 35,000 sq ft facility in Newark, NJ, is equipped with machine tools, 3D printers, chemical, electrical and mechanical engineering labs, as well as on-staff engineering and design experts. SOSV's IndieBio has locations in NYC and San Francisco, both of which offer extensive services and facilities to founders including on-site BSL-2 labs, well equipped lab benches and hoods, and advanced lab equipment, such as chromatography equipment.

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Investment focus

  • Industry: Biotechnology, Health Care, Software
  • Stage:Seed, Convertible Note, Pre-Seed
  • Geography: United States, India, United Kingdom

Investor stats

  • Total investments: 1482
  • Lead/follow: no public data

Portfolio highlights

  • MixRift — MIXRIFT - game developers specialized in Mixed Reality
  • unspun — From 3D scan to perfect fitting custom jeans. unspun makes each pair of jeans unique to your actual body and design. On a mission to reduce global carbon emissions by 1%. As seen in Fast Company's World Changing Ideas, Time's Best Inventions, and PopSci's Best of What's New. Welcome to the future of apparel.
  • Mesa Quantum — Unlock the potential of chip-scale quantum sensing for enhanced Position, Navigation, And Timing capabilities. Explore Mesa Quantum's practical solutions.
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Alumni Ventures
VC Fund · Manchester, New Hampshire, United States · 113 investments in United States Biotechnology startups

Access curated startup investment opportunities and diversified venture capital exposure designed for accredited investors.

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Investment focus

  • Industry: Software, Artificial Intelligence, Information Technology
  • Stage:Seed, Series A, Series B
  • Geography: United States, United Kingdom, Canada

Investor stats

  • Total investments: 2700
  • Round size: Seed $850k–$9.9M; Series A $3.5M–$32M; Series B $8M–$75M
  • Lead/follow: 4% lead, 96% follow
  • Last fund: Likely actively investing — fresh fund, raised $90k in 2026

Portfolio highlights

  • QuadSci — Customer Intelligence AI that predicts churn and growth from product telemetry, CRM data and conversational signals.
  • LOLIWARE — LOLIWARE is rewriting the story of destructive packaging. By harnessing the power of seaweed to replace plastic at scale, LOLIWARE is tapping into its potential to regenerate our ocean and decarbonize our planet.
  • Iambic — Iambic has created a cutting-edge AI-driven platform to tackle the most challenging design problems in drug discovery and address unmet patient need.
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OrbiMed
VC Fund · New York, New York, United States · 107 investments in United States Biotechnology startups

Leading Global Healthcare Platform with Deep Proprietary Resources and Global Industry Coverage.

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Investment focus

  • Industry: Biotechnology, Health Care, Medical
  • Stage:Series B, Series A, Series C
  • Geography: United States, China, Israel

Investor stats

  • Total investments: 738
  • Round size: Series A $9.8M–$140M; Series B $24M–$148M; Series C $19M–$160M
  • Lead/follow: 35% lead, 65% follow
  • Last fund: Likely actively investing — fresh fund, raised $192M in 2026

Portfolio highlights

  • Netmeds — Who we are - India's most convenient online pharmacyNetmeds.com, India Ki Pharmacy, is brought to you by the Dadha & Company – one of India’s most trusted pharmacies, with over 100 years’ experience in dispensing quality medicines. At netmeds.com, we help you look after your own health effortlessly as well as take care of loved oneswherever they may reside in India. You can buy and send medicines from any corner of the country - with just a few clicks of the mouse.
  • Acceleron Pharma — At Merck, we're following the science to tackle some of the world's greatest health threats. Get a glimpse of how we work to improve lives.
  • Affimed — At Affimed, they are committed to improving outcomes for patients with cancer. Their scientific team has been devoted to unlocking the power of the innate immune system for nearly two decades to provide a unqiue approach to fighting cancer. With their unparalleled expertise in innate immunity and innate cell engager-based medicines, they aim toovercome the limitations and challenges faced by current immuno-oncology (I-O) therapies.
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Atlas Venture
VC Fund · Cambridge, Massachusetts, United States · 94 investments in United States Biotechnology startups

Atlas Venture is an early-stage venture capital firm that creates and invests in biotech startup companies led by promising entrepreneurs focusing on life sciences innovation. Its seed-led venture creation strategy rigorously selects and focuses investment on compelling opportunities to build scalable businesses and realize value.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series A, Series B, Series C
  • Geography: United States, United Kingdom, Canada

Investor stats

  • Total investments: 458
  • Round size: Series A $3.6M–$75M; Series B $8M–$115M; Series C $6M–$95M
  • Lead/follow: 29% lead, 71% follow
  • Last fund: Likely actively investing — fresh fund, raised $400M in 2025

Portfolio highlights

  • E Ink — E Ink Corp. is a supplier of electronic paper display (EPD) technologies. Products made with E Ink's electronic ink are designed to possess a paper-like high contrast appearance, ultra-low power consumption, and a thin, light form. E Ink's technology is tailored for many consumer and industrial applications including handheld devices,watches, clocks, and public information and promotional signs.
  • Songbird — DropCatch.com helps you secure expiring domain names.
  • Ethyreal Bio — Ethyreal Bio is an early-stage biotechnology company developing precision, mechanism-driven therapies for thyroid diseases with high unmet medical needs.
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Google Ventures
VC Fund · Mountain View, California, United States · 92 investments in United States Biotechnology startups

GV supports innovative founders moving the world forward.

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Investment focus

  • Industry: Software, Health Care, Biotechnology
  • Stage:Series A, Series B, Seed
  • Geography: United States, United Kingdom, Israel

Investor stats

  • Total investments: 1455
  • Round size: Seed $1.2M–$16M; Series A $6.2M–$100M; Series B $16M–$121M
  • Lead/follow: 31% lead, 69% follow
  • Last fund: May invest from a new fund soon — raised $100M in 2014

Portfolio highlights

  • Tennr — Tennr is a custom AI assistant that accelerates research, answers complex questions, and generates custom reports.
  • Smarterer — Individuals and Fortune 500 companies use Smarterer to help close the gap between the skills they have and the skills they need. Their dynamic assessment engine leverages the freshest crowdsourced tests around, to rapidly pinpoint skill level with a credible score. In November 2014, Pluralsight, the global leader in online learning for serioussoftware developers, IT specialists and creative technologists, acquired Smarterer. As the world's largest curated e-learning library for professionals, the company offers instant access to more than 3,500 courses authored by top experts. Smarterer will continue to power crowdsourced assessments for freelancer marketplaces, e-learning providers and enterprise companies anywhere people need to prove their skills to connect with professional opportunities. The Smarterer community has answered over 56 million during 1.7 million test sessions, across hundreds of tests.
  • EveryONE Medicines — EveryONE Medicines develops nucleic acid therapeutics for pathogenic genetic mutation of patients.
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Khosla Ventures
VC Fund · Menlo Park, California, United States · 90 investments in United States Biotechnology startups

Khosla Ventures is a venture capital firm that invests in early- to late-stage companies across sectors like AI, healthcare, sustainability, and consumer technology. It manages multiple funds, focusing on startups with innovative technologies or business models. The firm primarily targets sectors like AI, climate tech, digital health, and medtech,offering strategic support to help build long-lasting companies.

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Investment focus

  • Industry: Software, Artificial Intelligence, Health Care
  • Stage:Series A, Series B, Seed
  • Geography: United States, India, United Kingdom

Investor stats

  • Total investments: 1437
  • Round size: Seed $1.9M–$25M; Series A $5.5M–$47M; Series B $11M–$100M
  • Lead/follow: 39% lead, 61% follow
  • Last fund: Likely actively investing — fresh fund, raised $31M in 2026

Portfolio highlights

  • Seeo — Daftar akun togel resmi bisa melalui via dana, ovo, gopay, linkaja kami juga menyediakan berbagai link togel terpercaya seperti bo togel hadiah 2d 200rb, bandar togel hadiah 4d 10 juta terpercaya, situs togel resmi dan terpercaya, agen togel terpercaya, daftar bandar togel terbesar dan terpercaya, bandar togel terbesar, situs togel prize 123, bo togel bolak balik dibayar dan banyak lainnya yang kami sediakan untuk pencinta link togel resmi di Indonesia.
  • Phia — Build your closet seamlessly, and find the best prices instantly.
  • Lovable — Build apps, websites, and digital products faster using Lovable's AI-powered platform, no deep coding skills required.
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New Enterprise Associates
VC Fund · Menlo Park, California, United States · 86 investments in United States Biotechnology startups

Foundational partners to ambitious founders at every stage of company-building.

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Investment focus

  • Industry: Software, Health Care, Biotechnology
  • Stage:Series A, Series B, Series C
  • Geography: United States, India, United Kingdom

Investor stats

  • Total investments: 1983
  • Round size: Series A $6M–$55M; Series B $10M–$90M; Series C $15M–$103M
  • Lead/follow: 38% lead, 62% follow
  • Last fund: Likely still investing — raised $468M in 2024

Portfolio highlights

  • Lot18 — Save on world class wines delivered to your door with Firstleaf's wine club. Get started now and join the more than 1 million wine lovers who have found their perfect wines!
  • Tableau — Tableau is visual analytics software for business intelligence. See and understand any data with Tableau.
  • Apprenda — Apprenda is a software layer that transforms any infrastructure into a policy-driven, hybrid cloud application platform.
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RA Capital Management
VC Fund · Boston, Massachusetts, United States · 84 investments in United States Biotechnology startups

RA Capital Management is an investment advisor based in Boston specializing in the life-sciences and drug development sectors. The company's team has been investing since 2002 and is comprised of professionals with training in biology, chemistry, and medicine and also has industry and business development experience at the executive and boardlevels. The company invests in companies with promising technologies and products.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series B, Series C, Post-IPO Equity
  • Geography: United States, United Kingdom, Canada

Investor stats

  • Total investments: 571
  • Round size: Series B $27M–$151M; Series C $44M–$182M; Post-IPO Equity $35M–$275M
  • Lead/follow: 35% lead, 65% follow
  • Last fund: Likely actively investing — fresh fund, raised $120M in 2025

Portfolio highlights

  • EvodiaBio — EvodiaBio is a bio-industrial firm that creates natural, sustainable scents for the food and beverage industries. Founded in 2021 and is based in Copenhagen, Capital Region.
  • Serapha Bio —
  • Windward Bio — Windward Bio is a clinical-stage, drug development company committed to improving outcomes for people living with serious immunological diseases.
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Access 48,091 investors

822 industries, 177 countries. Updated daily. Emails and phones included.

Browse database — It's Free!
Polaris Partners
VC Fund · Boston, Massachusetts, United States · 83 investments in United States Biotechnology startups

Polaris Partners invests in healthcare and biotechnology companies. Their healthcare portfolio companies' care delivery models include digital health, consumer-centric businesses, patient-provider solutions, data science, and analytics. Their life sciences and biotechnology portfolio companies focus on molecules and platforms, therapeutics,and genomics.

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Investment focus

  • Industry: Biotechnology, Health Care, Medical
  • Stage:Series B, Series A, Series C
  • Geography: United States, Ireland, Singapore

Investor stats

  • Total investments: 539
  • Round size: Series A $4.6M–$92M; Series B $7M–$100M; Series C $10M–$107M
  • Lead/follow: 27% lead, 73% follow
  • Last fund: Likely actively investing — fresh fund, raised $439M in 2025

Portfolio highlights

  • GreenFuel — GreenFuel Technologies Corporation (GFT) was a startup that developed a process of growing algae using emissions from fossil fuel combustion and solar panels, mainly to produce biofuel from algae.
  • Partnerware — Partnerware maximizes speed-to-market™ for channel-focused companies with the leading B2B Partner Relationship Management (PRM) solution, delivering measurable channel results in Internet time. As a multi-channel sales approach becomes critical in delivering value-added solutions to the marketplace, the need for PRM has grown dramatically.Partnerware provides distinct benefits for companies looking to leverage the power of indirect - Faster channel execution (from channel recruiting to product launches)- Measurable results from partner programs, channel marketing funds, and partner sales efforts- Increased market responsiveness to leap frog and stay ahead of competition- Easy implementation by deploying Web-based Partner Relationship Management solutions in Internet time
  • Living Proof — Living Proof was created for the purpose of applying advanced technology to solve the toughest beauty challenges from a completely fresh perspective. They are a team of scientists from outside beauty, led by MIT Institute Professor Dr. Bob Langer, and beauty authorities with a shared vision: to invent efficient formulas based on entirely newmolecules and breakthrough technologies for results you can see from across the room.
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Gaingels
VC Fund · New York, New York, United States · 79 investments in United States Biotechnology startups

Gaingels is a venture investment syndicate in service of the LGBT+ community and its allies, investing in companies with LGBT+ founders and C-suite leaders at all stages of growth, as well as in more established companies resolved on building more inclusive teams, with a global portfolio of 130+ companies and $70M in deployed investment capital todate. The Gaingels network also actively supports its portfolio in identifying and recruiting diverse talent to their C-suite and board leadership teams and fosters a vibrant global community of industry leaders, investors, operators, and entrepreneurs who share a common goal for positive social change through business and successful investments.

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Investment focus

  • Industry: Software, Health Care, Artificial Intelligence
  • Stage:Seed, Series A, Series B
  • Geography: United States, Canada, Mexico

Investor stats

  • Total investments: 1338
  • Round size: Seed $1M–$8.2M; Series A $5M–$35M; Series B $16M–$100M
  • Lead/follow: 1% lead, 99% follow
  • Last fund: Likely actively investing — fresh fund, raised $140k in 2026

Portfolio highlights

  • Catio — Cloud architecture platform enabling companies to excel with cloud native tech stacks, focused on tech stack evaluation, planning, and evolution, with the help of AI.
  • Epirus — Epirus is a high-growth technology company that develops cutting-edge directed energy systems and power management solutions to transform multiple industries.
  • Multiverse Computing — World leaders in quantum computing for the financial industry. The first quantum & quantum-inspired toolbox for finance.
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Third Rock Ventures
VC Fund · Boston, Massachusetts, United States · 78 investments in United States Biotechnology startups

Third Rock Ventures invests in transformational life science companies that show high growth potential and are well-positioned to make a difference in the marketplace. Third Rock Ventures believes in the companies we start and makes significant initial investments, which are frequently supplemented by strategic collaborations, to help our firmsprogress in life-changing medicines, technologies, and diagnostics.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series A, Series B, Series C
  • Geography: United States

Investor stats

  • Total investments: 176
  • Round size: Series A $19M–$110M; Series B $11M–$190M; Series C $20M–$108M
  • Lead/follow: 47% lead, 53% follow
  • Last fund: Likely still investing — raised $1.1B in 2022

Portfolio highlights

  • Corvia Medical — Corvia Medical is a medical device company, focuses on developing structural heart devices for the treatment of heart failure. The company develops InterAtrial Shunt Device (IASD), a transcatheter device designed to treat diastolic heart failure (DHF), also known as heart failure with preserved ejection fraction (HFpEF). It was founded in 2009and headquartered in Andover, Massachusetts.
  • NinePoint Medical — NinePoint Medical, Inc. is a transformational medical device company developing innovative, real-time, in vivo pathology devices. The company's first goal is to develop a device that enables remote pathology, or telepathology, which would facilitate immediate review of images during diagnostic procedures. This capability could potentiallyprovide physicians with immediately actionable information and eventually allow them to pursue therapeutic remedies at the time of diagnosis. This convergence of access, diagnosis and treatment during one procedure is expected to improve patient experiences and outcomes, improve the efficiency of care and provide important savings to the healthcare system. Headquartered in Cambridge, Mass., NinePoint is backed by Third Rock Ventures and Prospect Venture Partners.
  • Jounce Therapeutics — Concentra is a biosciences company.
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Versant Ventures
VC Fund · Menlo Park, California, United States · 76 investments in United States Biotechnology startups

Versant partners with exceptional entrepreneurs to build and fund breakthrough biotechnology companies around the globe.

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Investment focus

  • Industry: Biotechnology, Health Care, Medical
  • Stage:Series A, Series B, Series C
  • Geography: United States, Switzerland, Canada

Investor stats

  • Total investments: 322
  • Round size: Series A $5M–$78M; Series B $12M–$105M; Series C $12M–$108M
  • Lead/follow: 30% lead, 70% follow
  • Last fund: Likely still investing — raised $5M in 2024

Portfolio highlights

  • Inari Medical — Inari Medical is a commercial-stage medical device company focused on developing products to treat and transform the lives of patients suffering from venous diseases. They are focused on treating venous thromboembolism and improving the quality of life of patients suffering from this disease by safely and effectively removing blood clots. It hasdeveloped two minimally-invasive, novel catheter-based mechanical thrombectomy devices that are designed to remove large clots from large vessels and eliminate the need for thrombolytic drugs. The ClotTriever system is 510(k)-cleared by the FDA for thrombectomy in the peripheral vessels and is used to treat patients suffering from deep vein thrombosis. The FlowTriever system is 510(k)-cleared by the FDA for the treatment of pulmonary embolism.The company was founded in 2011 and is headquartered in Irvine, California.
  • Gate Bioscience — Gate Bioscience is developing Molecular Gates, a new frontier in protein elimination. Molecular Gates are small molecule drugs that selectively eliminate harmful extracellular proteins at their origin, inside cells, and prevent them from emerging to cause disease.
  • Dayra Therapeutics — Dayra Therapeutics manufactures peptide based medicines.
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F-Prime
VC Fund · Cambridge, Massachusetts, United States · 75 investments in United States Biotechnology startups

F-Prime Capital is a global venture capital firm investing in healthcare and technology, with a heritage that spans four decades.

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Investment focus

  • Industry: Health Care, Biotechnology, Medical
  • Stage:Series A, Series B, Series C
  • Geography: United States, United Kingdom, China

Investor stats

  • Total investments: 532
  • Round size: Series A $9.2M–$87M; Series B $15M–$112M; Series C $20M–$150M
  • Lead/follow: 25% lead, 75% follow

Portfolio highlights

  • Lemon Cash — Lemon Cash is digital wallet with FIAT and crypto capabilities. End to end digital ecosystem for Latin America.
  • PlasmaGen Biosciences — PlasmaGen BioSciences is an Indian Bio-pharmaceutical organization specializing exclusively in Plasma Protein Therapy.Headquartered in Bangalore- India, PlasmaGen has been making every effort in the domain of Plasma product Industry and has become an Imperative one stop destination for the medical fraternity for most of the plasma products need.They have a basket of plasma products and the widest range of immunoglobulins in India catering to the requisites of various realms viz. Haematology, Oncology, Immunology, Paediatrics, Rheumatology, Dermatology and Neurology.
  • Ultragenyx Pharmaceutical — Ultragenyx is focused on developing first-ever approved treatments for rare and ultrarare diseases and moving the rare disease community forward.
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Andreessen Horowitz
VC Fund · Menlo Park, California, United States · 68 investments in United States Biotechnology startups

Andreessen Horowitz (a16z) is a venture capital firm in Silicon Valley, California, investing in bold founders, innovators, and entrepreneurs building the future through technology.

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Investment focus

  • Industry: Software, Information Technology, Artificial Intelligence
  • Stage:Series A, Seed, Series B
  • Geography: United States, United Kingdom, Brazil

Investor stats

  • Total investments: 2063
  • Round size: Seed $1.6M–$16M; Series A $9M–$55M; Series B $17M–$112M
  • Lead/follow: 49% lead, 51% follow
  • Last fund: Likely actively investing — fresh fund, raised $1.2B in 2026

Portfolio highlights

  • Tennr — Tennr is a custom AI assistant that accelerates research, answers complex questions, and generates custom reports.
  • Sardine — Solve risk, compliance, and payments with one powerful API.
  • Socket — Socket fights vulnerabilities and provides visibility, defense-in-depth, and proactive supply chain protection for JavaScript, Python, and Go dependencies.
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5AM Ventures
VC Fund · Menlo Park, California, United States · 67 investments in United States Biotechnology startups

5AM Ventures is a venture capital firm that offers seed- and early-stage investments to its clients. The company’s client portfolio consists of firms in the biopharmaceutical, life sciences, medical technology, and research instrument industries. 5AM Ventures was founded in 2002 by John Diekman and Andrew Schwab and is based in California.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series A, Series B, Series C
  • Geography: United States, Switzerland, United Kingdom

Investor stats

  • Total investments: 195
  • Round size: Series A $13M–$70M; Series B $15M–$110M; Series C $14M–$105M
  • Lead/follow: 37% lead, 63% follow
  • Last fund: Likely still investing — raised $450M in 2022

Portfolio highlights

  • Mendra — Mendra is a biopharmaceutical company that uses AI to accelerate clinical development and commercialization of breakthrough medicines for diseases with high unmet need.
  • Skye Bioscience — We are focused on unlocking new therapeutic pathways for metabolic health. | Nasdaq: SKYE
  • ALX Oncology — ALX Oncology is a preclinical stage biotechnology company developing innovative immuno-oncology therapies for cancer. It is an independent, private biotechnology company.The founding of Alexo Therapeutics was based upon technology invented by Aaron Ring, K. Christopher Garcia, Kipp Weiskopf, Aron Levin, and Irving Weissman at Stanford University.This discovery involves soluble versions of signal regulatory protein-α (SIRPα) that have been engineered to bind CD47 with significantly greater affinity than natural SIRPα.1.
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MPM Capital
VC Fund · Cambridge, Massachusetts, United States · 67 investments in United States Biotechnology startups

Powering Breakthroughs in Life Sciences

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series B, Series A, Series C
  • Geography: United States, Canada, United Kingdom

Investor stats

  • Total investments: 239
  • Round size: Series A $10M–$80M; Series B $20M–$116M; Series C $12M–$109M
  • Lead/follow: 35% lead, 65% follow
  • Last fund: Likely still investing — raised $850M in 2021

Portfolio highlights

  • Orna Therapeutics — Orna Therapeutics is a biotechnology company dedicated to designing and delivering a new class of fully engineered circular RNA (oRNA) therapeutics with the potential to change the way we treat disease. Orna’s proprietary platform combines novel technology to create oRNAs that drive protein expression with validated and unique delivery solutions.
  • Aratana Therapeutics — Aratana is uniquely positioned to deliver new, high-quality medicines to address unmet needs in companion animal care. We are committed to bringing world class science to animal health for companion animals and the people who care for them. Our competitive advantage resides in our ability to identify, acquire and develop high-value commercialproducts for companion animals in a cost effective and efficient manner.
  • Rhythm Pharmaceuticals — Rhythm Pharmaceuticals is a global biopharmaceutical company committed to transforming the lives of patients with rare neuroendocrine diseases by rapidly advancing care and precision medicines that address the root cause.
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Innova Memphis
VC Fund · Memphis, Tennessee, United States · 66 investments in United States Biotechnology startups

Founded in 2007 by the Memphis Bioworks Foundation, Innova is a pre-seed, seed and early-stage investor focused on starting and funding high-growth companies in the Biosciences, Technology and AgBio fields across the state of Tennessee. Innova links capital with great ideas to create groundbreaking products and services.At Innova we invest instart-up companies, help them grow, and then assist them in linking with established corporations for licensing, buy-outs or further investments. We provide the synergy of experienced management, market expertise and venture capital to accelerate the development of new products and services into viable business units that can stand on their own and then take their place with a mature market leader, if desired.Whether an innovation is still on the drawing board or stalled in the market place the Innova staff has the expertise, skills, and experience to envision and create a functioning business unit that is prepared to thrive in the market place. Technical know-how, market-proven staffing, and "just-right" funding assure the greatest chance possible for success.

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Investment focus

  • Industry: Health Care, Medical, Medical Device
  • Stage:Seed, Pre-Seed, Convertible Note
  • Geography: United States, Germany, Argentina

Investor stats

  • Total investments: 284
  • Round size: Seed $25k–$1.5M; Pre-Seed $25k–$1.3M; Convertible Note $48k–$1.4M
  • Lead/follow: 26% lead, 74% follow
  • Last fund: Likely still investing — raised $40M in 2023

Portfolio highlights

  • HerdDogg — HerdDogg is a global herd health and data science platform. It is a two-part system that helps ranchers track health and proximity data from their herd. The company's device gathers the data captured by the ear tags and reports it directly to the rancher via an app or web database.
  • Insignum AgTech — Insignum AgTech develops biotech plants that communicate with producers, alerting them to an illness in its early stages.
  • Soiltech Wireless — Soiltech Wireless is a developer of ag-tech solutions to design electronic devices for agricultural professionals. Its product provides real-time data to drive efficiency and optimize quality. It also provides actionable data without installation hassles and creates scalable monitoring solutions for farmers.The company was founded in 2019 and isheadquartered in Rupert, Idaho.
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Fifty Years
VC Fund · San Francisco, California, United States · 62 investments in United States Biotechnology startups, 6 in the past 12 months

WE BACK HEROES using technology to solve the world's biggest problems

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Investment focus

  • Industry: Biotechnology, Health Care, Artificial Intelligence
  • Stage:Seed, Series A, Pre-Seed
  • Geography: United States, Germany, Canada

Investor stats

  • Total investments: 213
  • Round size: Seed $2M–$13M; Pre-Seed $572k–$3.3M; Series A $8.5M–$40M
  • Lead/follow: 17% lead, 83% follow
  • Last fund: Likely still investing — raised $90M in 2021

Portfolio highlights

  • Onepot.ai — Search 2.7 billion make-on-demand analogs from onepot CORE, get a quote, and we synthesize and QC them in our US-based lab. AI-powered custom synthesis.
  • Wafer — Wafer is an AI optimization platform that automatically accelerates AI models by generating efficient custom GPU kernels.
  • Adaption Labs — Adaptation creates AI systems that adjust to changing real-world circumstances.
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Canaan Partners
VC Fund · Menlo Park, California, United States · 60 investments in United States Biotechnology startups

Canaan is an early stage venture capital firm that invests in entrepreneurs with visionary ideas. With $5B under management, a diversified fund and over 190 exits to date, Canaan has invested in some of the world's leading technology and healthcare companies over the past 30 years. Canaan’s focus areas include fintech, enterprise/cloud,marketplaces, frontier tech, biopharma, digital health, and medtech.

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Investment focus

  • Industry: Software, Biotechnology, Health Care
  • Stage:Series A, Series B, Series C
  • Geography: United States, United Kingdom, Israel

Investor stats

  • Total investments: 770
  • Round size: Series A $5.5M–$45M; Series B $8M–$75M; Series C $8M–$60M
  • Lead/follow: 32% lead, 68% follow
  • Last fund: Likely still investing — raised $100M in 2024

Portfolio highlights

  • withco — Rebuilding main street, one share at a time.
  • Hermeus — Hermeus is developing hypersonic aircraft to connect the world faster than ever before.
  • GroundWork — GroundWork delivers Unified Monitoring for Real™ with an open software platform for shockingly easy integrations and customized visualizations of cloud, virtualization, network, application, server, and storage data.GroundWork Monitor is available in free (Core) and subscription versions with support (Enterprise).GroundWork was founded in 2004 andis headquartered in San Francisco, California with partners in Asia Pacific, Europe and South America.
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Liquid 2 Ventures
VC Fund · San Francisco, California, United States · 54 investments in United States Biotechnology startups

Liquid2 Ventures provides technology startups with seed-stage investments and is based in San Francisco, California. The firm was founded in 2015 by Joe Montana, Mike Miller, and Michael Ma.

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Investment focus

  • Industry: Software, Artificial Intelligence, Information Technology
  • Stage:Seed, Series A, Pre-Seed
  • Geography: United States, Mexico, Canada

Investor stats

  • Total investments: 1234
  • Round size: Seed $1.1M–$9.1M; Pre-Seed $125k–$2.7M; Series A $6M–$48M
  • Lead/follow: 1% lead, 99% follow
  • Last fund: Likely actively investing — fresh fund, raised $12M in 2026

Portfolio highlights

  • Albedo — Aerial quality imagery - from space.
  • Vulcan — Frontier AI for government, law, and policy | backed by @ycombinator @generalcatalyst @cubitcapital
  • Attention — Attention is building an AI co-pilot designed to automate repetitive, multi-app desktop tasks.
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Lux Capital
VC Fund · New York, New York, United States · 53 investments in United States Biotechnology startups

Lux Capital manages over $5 billion in assets focused on founding, seed, early-stage, and growth investments at the intersection of technology and the sciences. Lux takes an active role in helping entrepreneurs build successful businesses in high-growth sectors. Its investment team has built over 20 companies from scratch. Lux's investmentstrategy ensures portfolio companies are better connected, have a deeper insight, and command industry leadership faster than their competitors.

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Investment focus

  • Industry: Software, Artificial Intelligence, Health Care
  • Stage:Series A, Seed, Series B
  • Geography: United States, United Kingdom, Canada

Investor stats

  • Total investments: 687
  • Round size: Seed $1.8M–$25M; Series A $7.3M–$90M; Series B $13M–$150M
  • Lead/follow: 29% lead, 71% follow
  • Last fund: Likely actively investing — fresh fund, raised $10M in 2026

Portfolio highlights

  • Adimab — Premier Human Antibody Discovery and Optimization
  • Toonimo — Toonimo humanize the web user experience with an engaging and personalized step-by-step interactive walkthrough
  • Cajal Neuroscience — Cajal Neuroscience is a drug discovery company focused on neurodegenerative disease.
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The Column Group
VC Fund · San Francisco, California, United States · 53 investments in United States Biotechnology startups

The Column Group (TCG) is a venture ecosystem dedicated to fueling scientific innovation in the life sciences industry.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series A, Series B, Series C
  • Geography: United States

Investor stats

  • Total investments: 161
  • Round size: Series A $15M–$102M; Series B $22M–$120M; Series C $37M–$120M
  • Lead/follow: 37% lead, 63% follow
  • Last fund: Likely still investing — raised $100M in 2024

Portfolio highlights

  • Nura Bio — Nura Bio revolutionizes the treatment of neurological diseases with novel, life-changing neuroprotective medicines. Nura Bio was conceived in 2018 by The Column Group and its scientific founders.
  • InduPro — InduPro is a biotechnology company that specializes in protein therapeutics and cell-surface platform technologies.
  • Immune Design — Immune Design Corp. (IDC) uses breakthrough technology to develop safe and effective vaccines and therapeutics, with emphasis on the prevention and treatment of infectious disease. This goal is being achieved through dedicated research aimed towards a greater understanding of the immune system, and by developing a new generation of immune-basedproducts for the pharmaceutical industry. IDC is passionate about its mission to alleviate human suffering and pursues this goal with high energy and an unsurpassed standard of excellence
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DCVC
VC Fund · San Francisco, California, United States · 52 investments in United States Biotechnology startups

We are deep tech venture capital.

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Investment focus

  • Industry: Software, Artificial Intelligence, Machine Learning
  • Stage:Seed, Series A, Series B
  • Geography: United States, Canada, United Kingdom

Investor stats

  • Total investments: 487
  • Round size: Seed $1.1M–$9.1M; Series A $5.8M–$45M; Series B $15M–$130M
  • Lead/follow: 24% lead, 76% follow
  • Last fund: Likely actively investing — fresh fund, raised $5M in 2026

Portfolio highlights

  • CH4 Global — CH4 Global is an aquaculture solutions provider dedicated to urgently impacting climate change at scale. Lead by a world-class team of senior business builders, scientists and entrepreneurs, the company is initially leveraging proven science and technology for growing seaweed into innovative new livestock supplement that reduces methane produced bycows by up to 90%. Among early investors are a select group of prominent family offices and private investors. CH4 Global have also received non-dilutive capital support from government organizations from around the world. CH4 Global is a Delaware corporation based in Henderson, NV.
  • Regent — We build all-electric, passenger-carrying, wing-in-ground-effect vehicles to service coastal routes with technology available today.
  • Callosum — Callosum - Co-evolving chips & intelligence
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BioAdvance
VC Fund · Philadelphia, Pennsylvania, United States · 50 investments in United States Biotechnology startups

BioAdvance actively invests venture capital in therapies, medical devices, research tools, diagnostics and health IT in the Mid-Atlantic region.

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Investment focus

  • Industry: Biotechnology, Health Care, Medical
  • Stage:Seed, Series A
  • Geography: United States, Canada

Investor stats

  • Total investments: 125
  • Round size: Seed $350k–$3M; Series A $3M–$40M
  • Lead/follow: 14% lead, 86% follow
  • Last fund: May invest from a new fund soon — raised $20M in 2002

Portfolio highlights

  • Latus Bio — Latus Bio focuses on developing innovative gene therapy candidates using precision delivery to enhance the lives of patients. Latus identified proprietary AAV capsids for clinical use. The company plans to administer low doses of its product candidates, aiming to improve clinical safety and manufacturing.
  • Overwatch Health — Overwatch Health offers an AI-assisted virtual rehab for cardiac and pulmonary patients.
  • Palvella Therapeutics — Palvella Therapeutics is committed to developing safe and effective therapies that specifically target the root cause of genetic skin diseases.
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KdT Ventures
VC Fund · Austin, Texas, United States · 50 investments in United States Biotechnology startups

KdT Ventures is the standard for early-stage frontier science investing.

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Investment focus

  • Industry: Biotechnology, Health Care, Medical
  • Stage:Seed, Series A, Series B
  • Geography: United States, India, Canada

Investor stats

  • Total investments: 96
  • Round size: Seed $2.6M–$13M; Series A $9M–$70M; Series B $25M–$175M
  • Lead/follow: 9% lead, 91% follow
  • Last fund: Likely actively investing — fresh fund, raised $4.9M in 2026

Portfolio highlights

  • Zag Bio — Zag Bio is harnessing the immune system in a whole new way by targeting the thymus to change treatment possibilities for millions of patients with autoimmune diseases.
  • Skeletalis — Skeletalis is a biotechnology startup focused on developing next-generation precision medicines for musculoskeletal diseases, primarily osteoporosis.
  • Tacit Therapeutics — New broadly-applicable and non-immunogenic RNA gene therapy that can treat thousands of devastating illnesses.
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Apple Tree Partners
VC Fund · New York, New York, United States · 49 investments in United States Biotechnology startups

ATP, a global leader in life sciences venture capital, is developing the next generation of transformative biotechnology companies. ATP creates science-based companies starting with assets at various stages: from working with scientists on pre-IP ideas, to spinouts from existing company pipelines. The firm provides flexible capital, strategicinsight, and operational resources to build sustainable, research-driven enterprises. ATP invests in its portfolio companies from seed stage through IPO and beyond and supports their management teams in strategic transactions and synergistic business combinations.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series A, Series B, Seed
  • Geography: United States, Canada, United Kingdom

Investor stats

  • Total investments: 99
  • Round size: Seed $3.5M–$8M; Series A $15M–$75M; Series B $29M–$100M
  • Lead/follow: 64% lead, 36% follow
  • Last fund: May invest from a new fund soon — raised $1B in 2020

Portfolio highlights

  • Ascidian Therapeutics — Ascidian Therapeutics is a biotechnology company intended for medical use in medical and clinical gene therapy.
  • Red Queen Therapeutics — Staying ahead of viral threats with new innovations in antiviral therapy
  • Deep Apple Therapeutics — Deep Apple Therapeutics is discovering new small-molecule therapeutics with unprecedented speed and exceptional acumen.
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8VC
VC Fund · San Francisco, California, United States · 48 investments in United States Biotechnology startups

8VC is a technology and life sciences investment firm that partners with founders to develop transformational technologies. The firm focuses on creating long-term economic and societal value through its investments across various sectors, including healthcare and logistics.

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Investment focus

  • Industry: Software, Health Care, Artificial Intelligence
  • Stage:Series A, Seed, Series B
  • Geography: United States, United Kingdom, Canada

Investor stats

  • Total investments: 666
  • Round size: Seed $2.5M–$13M; Series A $7.7M–$55M; Series B $17M–$175M
  • Lead/follow: 33% lead, 67% follow
  • Last fund: Likely actively investing — fresh fund, raised $45M in 2026

Portfolio highlights

  • Saronic — Providing the most advanced and capable autonomous vessels in the maritime domain.
  • Lumber — Lumber automates scheduling, time tracking, payroll, and more for building contractors. Discover effortless construction workforce management software today.
  • Flywheel.io — Flywheel is a medical image management system that streamlines imaging data aggregation, harmonization, management and analysis at scale.
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Connecticut Innovations
VC Fund · Rocky Hill, Connecticut, United States · 48 investments in United States Biotechnology startups

At Connecticut Innovations, we see venture capital the way you see your business. Like no one else. We invest in innovative biotech, IT, and other industries.

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Investment focus

  • Industry: Health Care, Biotechnology, Software
  • Stage:Seed, Series A
  • Geography: United States, Israel, Canada

Investor stats

  • Total investments: 295
  • Round size: Seed $150k–$5.3M; Series A $2.1M–$25M
  • Lead/follow: 31% lead, 69% follow
  • Last fund: Likely still investing — raised $50M in 2023

Portfolio highlights

  • eBrevia — Analyze contracts at scale, extract key data, and identify risk with eBrevia. Draft and redline agreements in Microsoft Word with DraftPro.
  • CloudSEK — CloudSEK leverages contextual AI to predict and prevent cyber threats. Keep your organisation safe and secure.
  • Fitscript — FDA Recognized Fitness Programs for Diabetes, GLP-1 Therapy and Weight Management
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TCA Venture Group
VC Fund · Newport Beach, California, United States · 45 investments in United States Biotechnology startups

TCA Venture Group is the largest angel investor group in the United States, possessing more than 300 members in five networks in Los Angeles, Orange County, San Diego, Central Coast, and the Inland Empire. Its members provide funding and guidance to more early-stage, high-growth companies in Southern California than any other investment group.Members invest in companies in a wide range of industries, including the life sciences, biotech, IT, services, retail, Internet, financial, software, media, consumer products, and tech startups. TCA as a whole gives companies more than just capital; they also provide counsel, mentoring, and access to an extensive network of potential investors, customers, strategic partners, and management talent. Tech Coast Angels has been ranked by CB Insights to be among the Top 20 Angel Groups in the US; TCA was also ranked as #1 for Network Centrality, meaning we have more connections than anyone! If you are in the game-changing business, we are here to help.

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Investment focus

  • Industry: Health Care, Software, Biotechnology
  • Stage:Seed, Convertible Note, Venture - Series Unknown
  • Geography: United States, Canada, South Africa

Investor stats

  • Total investments: 367
  • Round size: Seed $600k–$3.8M; Convertible Note $50k–$7M; Venture - Series Unknown $400k–$8.5M
  • Lead/follow: 9% lead, 91% follow
  • Last fund: May invest from a new fund soon — last raise in 2015

Portfolio highlights

  • EdgeX — Edokonta builds software that allows hospitals to track mobile equipment, such as IV pumps and ultrasounds. The company was founded in 2018 and based in San Diego, California.
  • Nested Knowledge — Nested Knowledge is designing an interface that allows you to examine the data from a comprehensive literature review on research questions of interest. The interactive, nested features facilitate therapeutic comparisons, assist with research organization, and allow physicians to compare nuances across patient characteristics and outcomes.
  • Major Medical Devices — Major Medical Devices develops next-generation vascular devices for endovascular repair and related surgical procedures.
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Pfizer Venture Investments
VC Fund · New York, New York, United States · 45 investments in United States Biotechnology startups

Pfizer Venture Investments is a corporate venture capital firm that invests in areas of current or future strategic interest to Pfizer. It aims to remain at the forefront of life science advances. It identifies and invests in emerging companies that are developing transformative medicines and technologies that have the potential to enhance Pfizer’spipeline and shape the future of its industry.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series B, Series A, Series C
  • Geography: United States, United Kingdom, Switzerland

Investor stats

  • Total investments: 188
  • Round size: Series A $10M–$100M; Series B $20M–$120M; Series C $15M–$102M
  • Lead/follow: 27% lead, 73% follow
  • Last fund: May invest from a new fund soon — raised $600M in 2018

Portfolio highlights

  • Flare Therapeutics — Flare Therapeutics is a biotechnology company opening up a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders, Flare’s team has uncovered ‘switch sites,’ druggable regions that are key targets fortranscription factor regulation to address mutations that cause disease. Its drug discovery to target switch sites has rapidly advanced, resulting in an emerging pipeline of drug programs that address well-validated transcription factors, initially focused on precision oncology with future potential in neurology, rare genetic disorders, immunology, and inflammation.
  • Flexion Therapeutics — Flexion Therapeutics advances drug candidates through clinical proof of concept and beyond, in partnership with pharmaceutical and biotechnology companies. By providing expertise and sharing risk, Flexion effectively expands the portfolios of its partners.
  • TwoStep Therapeutics — TwoStep Therapeutics is developing novel tumor-targeting therapeutics for solid tumors.
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Omega Funds
VC Fund · Boston, Massachusetts, United States · 45 investments in United States Biotechnology startups

We aim to invest in exceptional founders and entrepreneurs and impactful products and platforms across multiple therapeutic areas.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series A, Series B, Series C
  • Geography: United States, Switzerland, United Kingdom

Investor stats

  • Total investments: 169
  • Round size: Series A $16M–$200M; Series B $38M–$165M; Series C $14M–$208M
  • Lead/follow: 28% lead, 72% follow
  • Last fund: Likely still investing — raised $470M in 2023

Portfolio highlights

  • Ousia Pharma — Ousia Pharma is paving the way for novel therapeutic strategies using peptide-drug-conjugates
  • Windward Bio — Windward Bio is a clinical-stage, drug development company committed to improving outcomes for people living with serious immunological diseases.
  • Protego Biopharma — Protego Biopharma develops therapeutics based on the clear human genetic link, excellent human safety profile, proof-of-principle efficacy. The company was founded in 2011 and is headquartered in San Diego, California.
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Sand Hill Angels
VC Fund · Mountain View, California, United States · 45 investments in United States Biotechnology startups

For over two decades, Sand Hill Angels has worked openly and collaboratively with venture capital funds, other angel organizations, and the Bay Area ecosystem that fosters the growth of technology startups.

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Investment focus

  • Industry: Software, Health Care, Biotechnology
  • Stage:Seed, Convertible Note, Series A
  • Geography: United States, Canada, India

Investor stats

  • Total investments: 590
  • Round size: Seed $940k–$6.2M; Series A $1.6M–$20M; Convertible Note $300k–$25M
  • Lead/follow: 2% lead, 98% follow

Portfolio highlights

  • PlusPlus — PlusPlus provides a learning and development SaaS platform for technical professionals. It automates the management of onboarding, workshops, and tech-talks at scale. With PlusPlus, companies attract and develop employees.
  • Clean Power Finance — Clean Power Finance (CPF) is building an online business-to-business marketplace to drive the mass-market adoption of solar. The company connects providers of capital who are committed to investing in residential solar with qualified solar marketers, installers and distributors who need residential solar finance products to differentiate and growtheir businesses. CPF raises 100 percent third-party‐owned project finance funds from institutional investors such as Morgan Stanley and Google, working with the investors to structure and launch the funds with managed risk and return profiles. CPF then markets the funds as solar leases and power purchase agreements (PPAs) to qualified solar professionals, including Paramount Solar and Real Goods Solar (Nasdaq: RSOL), through its licensed online solar sales platform, CPF Tools. CPF Tools is software-as-a-service that simplifies complex sales, quoting, proposal and finance processes and minimizes the “soft costs” of selling solar.CPF’s fund investors earn favorable returns on stable investments on the resulting portfolios of residential distributed generation projects. The company’s solar professional partners gain access to solar leases and power purchase agreements (PPAs) that they can brand and sell to homeowners who want the benefits of solar without the cost and hassle of owning and maintaining a system.CPF manages approximately half a billion dollars of capacity on behalf of fund investors, and supports more than 100 solar professional customers who currently use the CPF Market to sell residential solar finance products to homeowners in CA, CO, HI, MA and NJ. Thousands of solar professionals in all 50 states have extensively used CPF Tools to quote and design solar systems.
  • Magnetic Insight — Magnetic Insight (MI) introduced magnetic particle imaging into the preclinical diagnostic research market enabling quantitative cell tracking, imaging of vascular function, detecting metastatic tumors, visualizing inflammation, CAR-T cell therapies and initial research into regenerative medicine.
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Deerfield
VC Fund · New York, New York, United States · 44 investments in United States Biotechnology startups

Deerfield is an investment firm dedicated to advancing healthcare through investment, intelligence, and philanthropy. We work across the healthcare ecosystem, connecting people, capital, ideas, and technology in new and often unexpected ways.

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Investment focus

  • Industry: Health Care, Biotechnology, Medical
  • Stage:Series A, Series C, Series B
  • Geography: United States, United Kingdom, Canada

Investor stats

  • Total investments: 283
  • Round size: Series A $11M–$67M; Series B $30M–$114M; Series C $20M–$110M
  • Lead/follow: 42% lead, 58% follow
  • Last fund: Likely actively investing — fresh fund, raised $600M in 2025

Portfolio highlights

  • Neomorph — We engineer neomorphic protein surfaces to unlock targeted protein degradation.
  • Axon Therapies — Axon is pioneering a frontline therapy that leverages Splanchnic Ablation for Volume Management (SAVM) to treat a root cause of heart failure.
  • SHINE Technologies — Discover SHINE Technologies' innovative approach to fusion technology, producing medical isotopes, recycling nuclear waste, and generating energy.
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Mission BioCapital
VC Fund · Cambridge, Massachusetts, United States · 44 investments in United States Biotechnology startups, 8 in the past 12 months

Mission BioCapital is a life science venture capital firm that invests in early-stage companies. The company leadership team has a long history together, investing in and launching dozens of early-stage life science companies. They are located in regions with a rich concentration of research, discovery, and venture capital investment, and they areknown by leaders of portfolio companies for the expertise and deep support they provide.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series A, Series B, Venture - Series Unknown
  • Geography: United States, Switzerland, France

Investor stats

  • Total investments: 95
  • Round size: Series A $4.2M–$80M; Series B $21M–$112M; Venture - Series Unknown $2M–$70M
  • Lead/follow: 22% lead, 78% follow
  • Last fund: Likely still investing — raised $275M in 2021

Portfolio highlights

  • Deck Bio — Deck Bio develops T cell engagers that recognize multiple cancer signals, expanding the reach of immunotherapy to treat tumors that other therapies miss.
  • Beech Biotech — Beech Biotech is utilizing cutting-edge biology to develop innovative therapies for preeclampsia and other pregnancy-related issues. This business extends pregnancy and lessens the effects of premature birth.
  • Cloverleaf Bio — Cloverleaf Bio | Developing a new class of RNA therapeutics to revolutionize cancer therapy.
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Novartis Venture Fund
VC Fund · Basel, Basel-Stadt, Switzerland · 44 investments in United States Biotechnology startups

Learn about the approach the Novartis Venture Fund takes to investing in innovative life science companies developing biotechnology and biopharmaceutical therapeutics that address unmet patient needs.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series B, Series A, Series C
  • Geography: United States, Switzerland, United Kingdom

Investor stats

  • Total investments: 230
  • Round size: Series A $5.1M–$85M; Series B $11M–$120M; Series C $9M–$75M
  • Lead/follow: 25% lead, 75% follow
  • Last fund: May invest from a new fund soon — raised $200M in 2009

Portfolio highlights

  • Visiogen — Visiogen, Inc. is an ophthalmic medical device company specializing in the development of new vision alternatives for patients with cataracts, with and without presbyopia. As part of this mission, Visiogen created the Synchrony dual optic accommodating *intraocular lens (IOL)* for use in the surgical treatment of these conditions.The device isdesigned to provide patients with near, intermediate and distance vision in a seamless continuum without the need for glasses or contact lenses. To eliminate lens handling during surgery, the Synchrony dual optic IOL is provided in a pre-loaded injector. This patented technology has been approved in Europe with a CE Mark designation and is currently undergoing clinical trials in the United States.
  • Protego Biopharma — Protego Biopharma develops therapeutics based on the clear human genetic link, excellent human safety profile, proof-of-principle efficacy. The company was founded in 2011 and is headquartered in San Diego, California.
  • Rein Therapeutics — Rein Therapeutics is advancing a novel pipeline of first-in-class medicines to address unmet medical needs in orphan pulmonary and fibrosis indications.
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Dolby Family Ventures
VC Fund · San Francisco, California, United States · 44 investments in United States Biotechnology startups

Investing in early-stage companies solving the biggest science and engineering challenges since 2014.

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Investment focus

  • Industry: Biotechnology, Health Care, Software
  • Stage:Series A, Seed, Series B
  • Geography: United States, Austria, Germany

Investor stats

  • Total investments: 150
  • Round size: Seed $2M–$9.4M; Series A $6.5M–$50M; Series B $10M–$65M
  • Lead/follow: 9% lead, 91% follow
  • Last fund: May invest from a new fund soon — last raise in 2014

Portfolio highlights

  • Exciva — EXCIVA GmbH is a privately held biotech company focused on development of clinical stage therapeutics for various indications in neuropsychiatry.
  • Transition Metal Solutions — Transition harnesses wild microbial communities to recover copper and other critical metals from low-grade mining resources.
  • Molten Salt Solutions — Molten Salt Solutions: Lithium Isotope Enrichment for Advanced Nuclear Power
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Founders Fund
VC Fund · San Francisco, California, United States · 44 investments in United States Biotechnology startups

Founders Fund is a San Francisco based venture capital firm investing in companies building revolutionary technologies.

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Investment focus

  • Industry: Software, Health Care, Information Technology
  • Stage:Series A, Seed, Series B
  • Geography: United States, United Kingdom, Germany

Investor stats

  • Total investments: 1033
  • Round size: Seed $1.7M–$14M; Series A $5.5M–$50M; Series B $15M–$100M
  • Lead/follow: 33% lead, 67% follow
  • Last fund: Likely actively investing — fresh fund, raised $6B in 2026

Portfolio highlights

  • Ubyx — Ubyx is a clearing system that allows anyone,
  • SwishX — Indias First Employee Savings Platform
  • Valinor Enterprises — Valinor is a new kind of defense and government tech company. We build and buy mission-critical technologies to fill the gaps others ignore.
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Hatteras Venture Partners
VC Fund · Durham, North Carolina, United States · 43 investments in United States Biotechnology startups, 9 in the past 12 months

Hatteras Venture Partners is a venture capital firm based in Research Triangle Park, NC, with a focus on biopharmaceuticals, medical devices, diagnostics, and related opportunities in human medicine. Founded in 2000, the firm consists of an experienced team with a broad and complementary skill set that is particularly relevant to buildingsuccessful new biomedical companies. The Hatteras Venture Partners team brings operational experience, a successful track record, and a proven ability to enhance the value of the companies in which it invests. With three funds, the firm has more than $120 million under management.

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Investment focus

  • Industry: Health Care, Biotechnology, Medical
  • Stage:Series A, Series B, Series C
  • Geography: United States, Canada

Investor stats

  • Total investments: 141
  • Round size: Series A $2.6M–$50M; Series B $5M–$82M; Series C $8M–$88M
  • Lead/follow: 37% lead, 63% follow
  • Last fund: Likely still investing — raised $30M in 2023

Portfolio highlights

  • RapidPulse — Explore RapidPulse for innovative stroke treatments and technologies. Book appointments or learn about our team and clinical trials.
  • 410 Medical — 410 Medical has developed a simple, intuitive solution that allows a single healthcare provider to rapidly deliver fluid to critically ill patients, improving care, and saving lives. Their device allows fast set-up, improves resuscitation speed, minimizes provider fatigue, and frees providers to address other patient care issues simultaneously.This solution is particularly useful in pre-hospital settings and the emergency department and where speed is critical and resources may be limited.It was founded in 2013 and headquartered in Durham, North Carolina.
  • Ladder Health — Ladder Health offers virtual pediatric therapy and support for early childhood developmental delays, including speech and physical therapy.
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Casdin Capital
VC Fund · New York, New York, United States · 43 investments in United States Biotechnology startups, 6 in the past 12 months

Casdin Capital is a fundamental research investment firm focused on the life sciences and healthcare industry. It manages a long-short equity fund and makes investments in early-stage to late-stage private investments. Casdin was launched in 2012 by founder and CIO Eli Casdin and as of October 2020 has approximately $2.2 billion in assets undermanagement.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series B, Series A, Series C
  • Geography: United States, China, France

Investor stats

  • Total investments: 238
  • Round size: Series A $10M–$191M; Series B $34M–$143M; Series C $35M–$175M
  • Lead/follow: 17% lead, 83% follow
  • Last fund: May invest from a new fund soon — raised $30M in 2018

Portfolio highlights

  • Adlai Nortye — Adlai Nortye is a global clinical-stage biopharmaceutical company focused on innovative oncology drugs, with its R&D and global clinical operation centers in both China and the United States. With a strategic emphasis on oncology, it has built a global pipeline through collaborations and internal discoveries with more than 10 drug candidates indevelopment.
  • City Therapeutics — Leading the next-generation of RNAi trigger molecule engineering to develop a pipeline of disruptive medicines.
  • Flare Therapeutics — Flare Therapeutics is a biotechnology company opening up a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders, Flare’s team has uncovered ‘switch sites,’ druggable regions that are key targets fortranscription factor regulation to address mutations that cause disease. Its drug discovery to target switch sites has rapidly advanced, resulting in an emerging pipeline of drug programs that address well-validated transcription factors, initially focused on precision oncology with future potential in neurology, rare genetic disorders, immunology, and inflammation.
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Lightspeed Venture Partners
VC Fund · Menlo Park, California, United States · 42 investments in United States Biotechnology startups

Lightspeed Venture Partners is a multi-stage venture capital firm focused on accelerating disruptive innovations and trends.

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Investment focus

  • Industry: Software, Information Technology, Artificial Intelligence
  • Stage:Series A, Series B, Seed
  • Geography: United States, India, Israel

Investor stats

  • Total investments: 2368
  • Round size: Seed $2M–$27M; Series A $7M–$85M; Series B $15M–$125M
  • Lead/follow: 40% lead, 60% follow
  • Last fund: Likely actively investing — fresh fund, raised $600M in 2025

Portfolio highlights

  • Fiddler Labs — Monitor, observe, analyze, and explain your machine learning models in production with Fiddler AI. Maximize ML model performance with our Model Performance Management Platform that simply plugs in.
  • Fresh Nation — Fresh Nation is an enterprise-level B2B wholesale marketplace and management platform for the retail grocery industry, operationalizing local and specialty food assortments for the nation’s largest retailers and distributors. Fresh Nation’s proprietary Virtual Supply Chain™ platform simplifies the complexity of working with thousands of smallvendors, saving time and cutting costs. Incorporating a vendor and product rich CRM, interactive supplier portal, order management suite, accounting and invoicing tools, and flexible EDI/API integrations, Fresh Nation is becoming the grocery industry standard for enterprise specialty food management.
  • Ricursive Intelligence — We develop frontier AI methods to reinvent chip development, collapsing traditional design timelines, closing the loop between AI and the hardware that fuels it, and enabling a Cambrian explosion of custom silicon.
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Life Science Angels
VC Fund · Sunnyvale, California, United States · 42 investments in United States Biotechnology startups

Life Science Angels, Inc. (LSA) is the premier angel investment group focused solely on healthcare investing, including medical devices, diagnostics, pharmaceuticals, biotechnology, and digital health.

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Investment focus

  • Industry: Biotechnology, Health Care, Medical
  • Stage:Seed, Series A
  • Geography: United States, Israel, The Netherlands

Investor stats

  • Total investments: 95
  • Round size: Seed $1M–$4M; Series A $1.3M–$10M
  • Lead/follow: 8% lead, 92% follow

Portfolio highlights

  • ATDev — ATDev builds robotic mobility and assistive technology for older adults and people with disabilities
  • Journey Live — Journey is shifting the way modern companies prioritize mental health. Our proactive, inclusive tools engage every employee, every day.
  • Trio Pharmaceuticals — Trio Pharmaceuticals is a cancer therapeutics company that develops dual-action drugs for immunogenic tumors. These drugs directly stop tumor growth and selectively stop immunosuppression in the tumor without targeting the current immune checkpoint pathways. The company was founded in 2018 and is headquartered in San Diego, California.
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Refactor
VC Fund · Burlingame, California, United States · 42 investments in United States Biotechnology startups

Refactor is a seed-stage hard tech venture firm. Solo GP Zal Bilimoria writes $1-2M checks into founders building in aerospace, energy, bio, health, nuclear, defense, advanced manufacturing, and critical materials. Better Call Zal.

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Investment focus

  • Industry: Health Care, Biotechnology, Medical
  • Stage:Seed, Series A, Series B
  • Geography: United States, United Kingdom, New Zealand

Investor stats

  • Total investments: 118
  • Round size: Seed $2.5M–$11M; Series A $8M–$34M; Series B $16M–$103M
  • Lead/follow: 19% lead, 81% follow
  • Last fund: Likely actively investing — fresh fund, raised $50M in 2026

Portfolio highlights

  • Pila Energy — Energy Independence for Everyone.
  • The Biological Computing — Biological Black Box integrates biological neurons with artificial neural networks to develop a living computer.
  • Berkeley Yeast — Better yeast for better beer. Make cleaner tasting beer with ultra low diacetyl strains, brew non alcoholic beer that tastes more like actual beer, or unlock bright grapefruit and passionfruit notes with the cleanest thiol yeast.
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Northpond Ventures
VC Fund · Bethesda, Maryland, United States · 41 investments in United States Biotechnology startups

Northpond Ventures is a science-driven venture capital firm headquartered in Bethesda, Maryland. Our mission is to build a better tomorrow. Our investments are focused on life sciences, technology, and affiliated industries.

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Investment focus

  • Industry: Biotechnology, Health Care, Life Science
  • Stage:Series A, Series B, Series C
  • Geography: United States, United Kingdom, Canada

Investor stats

  • Total investments: 151
  • Round size: Series A $13M–$65M; Series B $15M–$95M; Series C $23M–$85M
  • Lead/follow: 59% lead, 41% follow

Portfolio highlights

  • Faro AI — The AI Platform for Clinical Development
  • Culture Biosciences — Culture Biosciences provides a platform of cloud-connected bioreactors, software tools, and process development services that support upstream bioprocess development for biotech and biopharma applications. The company’s offerings include remote experiment design, monitoring, and data analysis through an integrated cloud software interface pairedwith single-use bioreactors for microbial fermentation and cell culture experimentation. Its services encompass clone and strain screening, process optimization, characterization, and bioprocess modeling to help scientific teams refine and scale their workflows. Clients access real-time data and analytics to inform decisions and collaborate across teams using the platform’s tools. Culture Biosciences’s technology is used to advance development of therapeutics, synthetic biology products, and related bioprocesses. Culture Biosciences was founded in 2016 and is headquartered in San Francisco, California.
  • EnPlusOne Biosciences — EnPlusOne Biosciences provides innovative solutions for emerging RNA therapeutics.
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Novo Holdings
VC Fund · Hellerup, Hovedstaden, Denmark · 41 investments in United States Biotechnology startups

Novo Holdings is a world-leading life science investor with a focus on creating long-term value.

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Investment focus

  • Industry: Biotechnology, Health Care, Medical
  • Stage:Series A, Series B, Series C
  • Geography: United States, Denmark, United Kingdom

Investor stats

  • Total investments: 398
  • Round size: Series A $9.5M–$133M; Series B $15M–$135M; Series C $30M–$118M
  • Lead/follow: 39% lead, 61% follow
  • Last fund: May invest from a new fund soon — raised $165M in 2018

Portfolio highlights

  • Santaris Pharma — Spearheading RNA molecule research since 2003, our site in Copenhagen is focused on leading chemistry for targeting any type of transcribed RNA using short synthetic single-strand oligonucleotides. Here, our experts in the field pioneered our core technology platform of locked nucleic acids (LNA) and antisense oligonucleotides (ASO).
  • PTC Therapeutics — Translating Science. Transforming Lives.
  • SCHOTT Poonawalla — SCHOTT Poonawalla is a manufacturer of pharmaceutical containers, made of neutral glass tubing. The company provides parenteral packaging systems crafted from tubular glass, serving the pharmaceutical industry with a broad range of products including vials, pre-fillable syringes, ampoules, and cartridges.
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General Catalyst
VC Fund · Cambridge, Massachusetts, United States · 41 investments in United States Biotechnology startups

Investing in powerful, positive change that endures

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Investment focus

  • Industry: Software, Artificial Intelligence, Health Care
  • Stage:Series A, Seed, Series B
  • Geography: United States, United Kingdom, India

Investor stats

  • Total investments: 2248
  • Round size: Seed $1.7M–$18M; Series A $6.9M–$75M; Series B $14M–$123M
  • Lead/follow: 46% lead, 54% follow
  • Last fund: Likely actively investing — fund raised in 2026

Portfolio highlights

  • Envoy Global — 25 years. 180+ countries. 2,000+ corporate clients. Envoy combines legal expertise and technology to simplify global immigration management.
  • Kouper Health — The transitions-of-care platform ensuring patients receive timely access to follow-up care.
  • Manas AI — Disrupting drug development & finding cures faster.
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Flagship Pioneering
VC Fund · Cambridge, Massachusetts, United States · 41 investments in United States Biotechnology startups

We create breakthroughs in human health and sustainability and build bioplatform companies . Companies founded

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Investment focus

  • Industry: Biotechnology, Health Care, Medical
  • Stage:Series B, Series C, Series A
  • Geography: United States, Canada, United Kingdom

Investor stats

  • Total investments: 252
  • Round size: Series A $6.5M–$88M; Series B $11M–$230M; Series C $12M–$123M
  • Lead/follow: 46% lead, 54% follow
  • Last fund: Likely still investing — raised $2.6B in 2024

Portfolio highlights

  • ZoomInfo — ZoomInfo provides access to more direct dials and email addresses than any other B2B contact provider. Verified professional and business profiles come fully loaded with detailed information about prospects, including web mentions, employment history, and direct access to colleagues, people can engage ideal buyer personas and accounts in a moremeaningful way. ZoomInfo uses its diverse portfolio of proprietary technology, a community of 300,000+ users, and third-party integrations to collect, organize, validate, and publish a comprehensive directory of business data in the marketplace.ZoomInfo's mission is to provide every company with a 360-degree view of their ideal customer, empowering each phase of their go-to-market strategy, and driving their ability to hit their number. ZoomInfo was founded in 2000 and is headquartered in Waltham, Massachusetts.
  • Foghorn Therapeutics — Foghorn Therapeutics is developing therapies based on a system that directs which genes our cells express, and when, where, and in what order.By manipulating this system with our unique Gene Traffic ControlTM platform, Foghorn will change how genes turn “on” and “off.” Unlike approaches that edit genes, this novel way of thinking will alter whatour DNA has in store for us—and rewrite destiny for millions of people living with disease.With Gene Traffic ControlTM Foghorn is pioneering a new, major class of drug targets to develop unprecedented therapies for cancer and other serious diseases. We have already validated multiple targets, are in the process of developing drug candidates in multiple types of cancer and are beginning to explore other diseases.
  • Serif Bio­med­i­cines — Serif Biomedicines is pioneering Modified DNA as a new type of biotechnology. Serif combines nucleic acid chemistry, synthetic biology, delivery technology, and artificial intelligence to develop programmable, scalable, long-lasting, and redosable DNA therapies.
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Frazier Healthcare Partners
VC Fund · Seattle, Washington, United States · 40 investments in United States Biotechnology startups

With its purpose-driven culture and deep industry expertise, the Frazier Growth Buyout team is the preferred partner to profitable healthcare companies.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series B, Series A, Post-IPO Equity
  • Geography: United States, Canada, Ireland

Investor stats

  • Total investments: 181
  • Round size: Series A $10M–$73M; Series B $10M–$110M; Post-IPO Equity $15M–$200M
  • Lead/follow: 27% lead, 73% follow
  • Last fund: Likely actively investing — fresh fund, raised $2.3B in 2024

Portfolio highlights

  • Simpata — Simpata Inc is a software company that provides its clients with internet-based application services of employee human resources.
  • Nuon Therapeutics — Nuon Therapeutics is focused on the development and commercialization of new therapies in inflammation and neurological diseases, including rheumatoid arthritis (RA), multiple sclerosis (MS) and neuropathic pain.
  • Zeltiq Aesthetics — Learn about the CoolSculpting cryolipolysis procedure.
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Foresite Capital
VC Fund · San Francisco, California, United States · 40 investments in United States Biotechnology startups

We are a multi-stage investment firm, investing in companies that leverage biology and big data to transform healthcare.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series B, Series C, Series A
  • Geography: United States, United Kingdom, China

Investor stats

  • Total investments: 223
  • Round size: Series A $17M–$165M; Series B $25M–$140M; Series C $37M–$270M
  • Lead/follow: 29% lead, 71% follow
  • Last fund: Likely still investing — raised $900M in 2024

Portfolio highlights

  • Korsana Biosciences — Korsana Biosciences develops THETA-enabled antibody therapies for neurodegenerative diseases. The company focuses on shuttled monoclonal antibodies that cross the blood-brain barrier to reach central nervous system targets. Its lead program, KRSA-028, is an investigational anti-amyloid beta antibody for Alzheimer’s disease that uses a transferrinreceptor-based shuttle and Fc engineering to improve brain delivery and dosing. Korsana is also advancing additional THETA-based programs for undisclosed neurodegenerative indications.
  • Parabilis Medicines — Parabilis Medicines is a biopharmaceutical company in the clinical stage that focuses on developing exceptional medications targeting challenging protein structures previously deemed undruggable. Utilizing more than ten years of exclusive data, innovative laboratory techniques, and algorithms based on AI and physics, the company has introduced anovel category of stabilized, cell-penetrating alpha-helical peptides known as Helicons™. These peptides can modulate intracellular proteins that traditional drug modalities cannot reach.
  • Aeovian Pharmaceuticals — Aeovian is a San Francisco based biopharmaceutical company developing novel and highly selective therapeutics modulating mTORC1 pathway.
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Biotechnology VC funding in United States at a glance

Stats across 20k deals from 9.2k investors.

9.2k
investors
in United States Biotechnology startups
20k
deals
in United States Biotechnology startups
$10M
median round
in United States Biotechnology startups
44%
lead investors
lead at least one round
17%
Grant
most common funding stage

Access all 9202 VC funds in United States Biotechnology startups.

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