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Top 50 Biotechnology VC Funds & Investors in United States (October 2026)

The most active venture capital funds investing in United States Biotechnology startups. This investor list is updated monthly from the Shizune investor database, ranked by number of investments in United States Biotechnology startup companies. Find investors to raise a Seed, Series A or Series B round with Shizune.
Investor Relevant Deals Geography Stage Focus Round Size
SOSV
VC Fund
424 United States, China, Canada Seed, Convertible Note, Pre-Seed Biotechnology, Health Care, Software $50k–$5M
SOSV SF & NY (Fka IndieBio)
VC Fund
274 United States, United Kingdom, Canada Seed, Pre-Seed, Convertible Note Biotechnology, Health Care, Medical $50k–$5M
ARCH Venture Partners
VC Fund
163 United States, China, United Kingdom Series A, Series B, Series C Biotechnology, Health Care, Therapeutics $9.1M–$230M
Alexandria Venture Investments
VC Fund
128 United States, Canada, France Series A, Series B, Series C Biotechnology, Health Care, Therapeutics $12M–$150M
Alumni Ventures
VC Fund
113 United States, United Kingdom, Canada Seed, Series A, Series B Software, Artificial Intelligence, Health Care $850k–$75M
OrbiMed
VC Fund
109 United States, China, Israel Series B, Series A, Series C Biotechnology, Health Care, Pharmaceutical $9M–$160M
Atlas Venture
VC Fund
99 United States, United Kingdom, Canada Series A, Series B, Seed Biotechnology, Health Care, Therapeutics $750k–$115M
Google Ventures
VC Fund
93 United States, United Kingdom, Israel Series A, Series B, Seed Software, Health Care, Biotechnology $1.1M–$121M
New Enterprise Associates
VC Fund
90 United States, China, India Series A, Series B, Series C Software, Health Care, Biotechnology $6M–$100M
Khosla Ventures
VC Fund
90 United States, United Kingdom, India Series A, Seed, Series B Artificial Intelligence, Software, Health Care $1.7M–$100M
Polaris Partners
VC Fund
86 United States, Ireland, Singapore Series B, Series A, Series C Health Care, Biotechnology, Medical $4.6M–$105M
RA Capital Management
VC Fund
84 United States, United Kingdom, China Series B, Post-IPO Equity, Series A Biotechnology, Health Care, Therapeutics $20M–$275M
Versant Ventures
VC Fund
79 United States, Switzerland, Canada Series A, Series B, Series C Biotechnology, Health Care, Medical $5M–$107M
Gaingels
VC Fund
79 United States, Canada, United Kingdom Seed, Series A, Venture - Series Unknown Software, Artificial Intelligence, Health Care $72k–$35M
F-Prime
VC Fund
78 United States, China, United Kingdom Series A, Series B, Seed Health Care, Biotechnology, Medical $1.6M–$112M
Third Rock Ventures
VC Fund
78 United States, Japan, Israel Series A, Series B, Series C Biotechnology, Health Care, Therapeutics $11M–$190M
Andreessen Horowitz
VC Fund
70 United States, United Kingdom, Canada Series A, Seed, Series B Software, Artificial Intelligence, Information Technology $1.5M–$120M
5AM Ventures
VC Fund
68 United States, Switzerland, United Kingdom Series A, Series B, Series C Biotechnology, Health Care, Therapeutics $13M–$110M
MPM Capital
VC Fund
67 United States, Canada, United Kingdom Series B, Series A, Series C Biotechnology, Health Care, Therapeutics $10M–$116M
Innova Memphis
VC Fund
66 United States, Germany, Argentina Seed, Pre-Seed, Convertible Note Health Care, Medical, Medical Device $25k–$1.5M
Fifty Years
VC Fund
62 United States, Germany, Canada Seed, Series A, Pre-Seed Biotechnology, Health Care, Artificial Intelligence $572k–$40M
Canaan Partners
VC Fund
61 United States, Israel, United Kingdom Series A, Series B, Seed Software, Biotechnology, Health Care $1.8M–$75M
Lux Capital
VC Fund
58 United States, United Kingdom, Canada Series A, Seed, Series B Software, Artificial Intelligence, Health Care $1.6M–$150M
DCVC
VC Fund
57 United States, United Kingdom, Canada Seed, Series A, Series B Software, Artificial Intelligence, Machine Learning $1M–$130M
Liquid 2 Ventures
VC Fund
54 United States, Mexico, Canada Seed, Pre-Seed, Series A Software, Artificial Intelligence, Information Technology $125k–$48M
The Column Group
VC Fund
53 United States Series A, Series B, Series C Biotechnology, Health Care, Therapeutics $15M–$120M
Connecticut Innovations
VC Fund
51 United States, Israel, Canada Seed, Series A, Series B Health Care, Biotechnology, Software $150k–$75M
KdT Ventures
VC Fund
50 United States, India, Canada Seed, Series A, Series B Biotechnology, Health Care, Medical $2.6M–$175M
BioAdvance
VC Fund
50 United States, Canada Seed, Series A Biotechnology, Health Care, Medical $350k–$40M
Apple Tree Partners
VC Fund
49 United States, Canada, United Kingdom Series A, Series B, Seed Biotechnology, Health Care, Therapeutics $3.5M–$100M
8VC
VC Fund
48 United States, United Kingdom, Canada Seed, Series A, Series B Software, Artificial Intelligence, Health Care $2.5M–$181M
Novartis Venture Fund
VC Fund
47 United States, Switzerland, United Kingdom Series B, Series A, Series C Biotechnology, Health Care, Therapeutics $5.1M–$107M
TCA Venture Group
VC Fund
47 United States, Canada, South Africa Seed, Venture - Series Unknown, Convertible Note Health Care, Software, Biotechnology $50k–$8.5M
Founders Fund
VC Fund
46 United States, United Kingdom, Germany Series A, Seed, Series B Software, Artificial Intelligence, Health Care $1.7M–$100M
Sand Hill Angels
VC Fund
46 United States, Canada, India Seed, Convertible Note, Series A Software, Health Care, Biotechnology $300k–$25M
Deerfield
VC Fund
46 United States, United Kingdom, Canada Series A, Series C, Venture - Series Unknown Health Care, Biotechnology, Medical $3M–$120M
Pfizer Venture Investments
VC Fund
46 United States, United Kingdom, Switzerland Series B, Series A, Series C Biotechnology, Health Care, Therapeutics $12M–$120M
Omega Funds
VC Fund
45 United States, Switzerland, United Kingdom Series A, Series B, Series C Biotechnology, Health Care, Therapeutics $14M–$208M
Mission BioCapital
VC Fund
45 United States, Switzerland, France Series A, Series B, Venture - Series Unknown Biotechnology, Health Care, Therapeutics $2M–$112M
Casdin Capital
VC Fund
45 United States, China, France Series B, Series A, Series C Biotechnology, Health Care, Therapeutics $8.1M–$191M
Dolby Family Ventures
VC Fund
45 United States, Austria, Germany Series A, Seed, Series B Biotechnology, Health Care, Software $2M–$65M
Keiretsu Forum
VC Fund
44 United States, India, Turkey Venture - Series Unknown, Seed, Series A Health Care, Software, Biotechnology $125k–$8.2M
Hatteras Venture Partners
VC Fund
43 United States, Canada Series A, Series B, Series C Health Care, Biotechnology, Medical $2.6M–$88M
Flagship Pioneering
VC Fund
43 United States, Canada, United Kingdom Series B, Series C, Series A Biotechnology, Health Care, Medical $6.6M–$230M
Refactor
VC Fund
43 United States, United Kingdom, New Zealand Seed, Series A, Series B Health Care, Biotechnology, Medical $2.7M–$103M
Lightspeed Venture Partners
VC Fund
43 United States, India, Israel Series A, Seed, Series B Software, Artificial Intelligence, Information Technology $2M–$125M
Life Science Angels
VC Fund
42 United States, Israel, The Netherlands Seed, Series A Biotechnology, Health Care, Medical $1M–$10M
Keiretsu Capital
VC Fund
42 United States, Canada, India Series A, Convertible Note, Seed Health Care, Biotechnology, Software $50k–$12M
Novo Holdings
VC Fund
42 United States, Denmark, United Kingdom Series A, Series B, Series C Biotechnology, Health Care, Medical $9.5M–$135M
General Catalyst
VC Fund
41 United States, India, United Kingdom Seed, Series A, Series B Software, Artificial Intelligence, Health Care $1.6M–$123M
Access all 9357 VC funds in United States Biotechnology startups.

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822 industries, 177 countries. Updated daily. Emails and phones included.

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Investor list

SOSV
VC Fund · Princeton, New Jersey, United States · 424 investments in United States Biotechnology startups

SOSV offers pre-seed capital and follow-on financial support to startups focusing on deep technology and scientific innovation. Founders utilize purpose-built laboratory facilities and engineering spaces to accelerate product development and testing. The firm facilitates connections between entrepreneurs and a network of investors through structured matchmaking events and technology summits.

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Investment focus

  • Industry: Biotechnology, Health Care, Software
  • Stage:Seed, Convertible Note, Pre-Seed
  • Geography: United States, China, Canada

Investor stats

  • Total investments: 3729
  • Round size: Seed $150k–$5M; Pre-Seed $50k–$1.6M; Convertible Note $50k–$3.6M
  • Lead/follow: 37% lead, 63% follow
  • Last fund: Likely still investing — raised $306M in 2023

Portfolio highlights

  • Halla — Halla Intelligence is a digital solution that leverages over 100 billion shopper and product data points to recommend and promote what grocery items.
  • Simply Good Jars — Simply Good Jars is a B-Corp company that delivers healthy meals in reusable + returnable packaging through use of smart refrigerated kiosks placed in offices, transit centers, universities and health-systems. Driven by purpose to change that way people think about consumption, SGJ introduces sustainable business practices into their everydayoperations with a zero-waste goal. For every jar returned back to the company for reuse, they will help feed someone in need and ensure that no packaging materials end up in landfills.
  • Verdex Technologies — Verdex Technologies is an advanced materials platform technology that uses nanofibers to disrupt industries. Verdex doesn't just compete, it innovates and disrupts.
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SOSV SF & NY (Fka IndieBio)
VC Fund · San Francisco, California, United States · 274 investments in United States Biotechnology startups

IndieBio, re-named SOSV SF and SOSV NY in 2026, are two of SOSV’s three deeply resourced facilities for deep tech founders. The third is SOSV's HAX, in Newark, NJ. SOSV is the most active deep tech venture capital firm globally.

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Investment focus

  • Industry: Biotechnology, Health Care, Medical
  • Stage:Seed, Pre-Seed, Convertible Note
  • Geography: United States, United Kingdom, Canada

Investor stats

  • Total investments: 676
  • Round size: Seed $250k–$5M; Pre-Seed $50k–$525k; Convertible Note $150k–$950k
  • Lead/follow: 3% lead, 97% follow

Portfolio highlights

  • FluoSphera — Fluosphera better predicts the effects of molecules through animal-free microphysiological systems, helping you to discover more efficient drugs with less adverse side effects.
  • Giraffe Bio — Giraffe Bio uses AI and biomolecules to optimize metal extraction, increase yield, and reduce environmental impact. Revolutionizing sustainable mining technology.
  • Transition Metal Solutions — Transition harnesses wild microbial communities to recover copper and other critical metals from low-grade mining resources.
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ARCH Venture Partners
VC Fund · Chicago, Illinois, United States · 163 investments in United States Biotechnology startups

ARCH Venture Partners provides seed / early stage venture capital for technology firms in information technology, life sciences, and physical sciences

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series A, Series B, Series C
  • Geography: United States, China, United Kingdom

Investor stats

  • Total investments: 475
  • Round size: Series A $9.1M–$213M; Series B $15M–$230M; Series C $15M–$167M
  • Lead/follow: 32% lead, 68% follow
  • Last fund: Likely still investing — raised $3B in 2024

Portfolio highlights

  • Oratomic — Oratomic is a Pasadena-based quantum computing company building fault-tolerant quantum computers with neutral atoms.
  • Synchron — The endovascular brain computer interface.
  • Soufflé Therapeutics — Soufflé Therapeutics is a biotechnology company specializing in the development of nucleic acid medicines designed for precise delivery and targeting of disease-causing cells. The company's mission is to create potent, precise, and safe medicines that can be tailored for a broad range of diseases by leveraging breakthroughs in genetic medicineand drug delivery technology.
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Alexandria Venture Investments
VC Fund · Pasadena, California, United States · 128 investments in United States Biotechnology startups, 15 in the past 12 months

Alexandria Venture Investments is a venture capital firm that develops work in real estate technology, and healthcare sectors. The company's strategic venture capital platform is Alexandria Venture Investments. Since its inception in 1996, the company has invested in disruptive life science, agrifood tech, and technology companies that are developing transformative new modalities and platforms to meaningfully improve human health.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series A, Series B, Series C
  • Geography: United States, Canada, France

Investor stats

  • Total investments: 298
  • Round size: Series A $12M–$100M; Series B $25M–$150M; Series C $22M–$140M
  • Lead/follow: 8% lead, 92% follow

Portfolio highlights

  • Leal Therapeutics — Leal Therapeutics develops novel therapeutics for patients.
  • BigHat Biosciences — We use machine learning and synthetic biology to design and engineer antibody therapeutics.
  • Khartis Therapeutics — Khartis is a drug discovery company developing oral therapies for patients with immune-mediated and chronic diseases. The company focuses on discovering and developing drug candidates intended to address chronic conditions and immune-mediated diseases.
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Alumni Ventures
VC Fund · Manchester, New Hampshire, United States · 113 investments in United States Biotechnology startups

Access curated startup investment opportunities and diversified venture capital exposure designed for accredited investors.

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Investment focus

  • Industry: Software, Artificial Intelligence, Health Care
  • Stage:Seed, Series A, Series B
  • Geography: United States, United Kingdom, Canada

Investor stats

  • Total investments: 2705
  • Round size: Seed $850k–$9.9M; Series A $3.5M–$32M; Series B $8M–$75M
  • Lead/follow: 4% lead, 96% follow
  • Last fund: Likely actively investing — fresh fund, raised $90k in 2026

Portfolio highlights

  • NextDroid — NextDroid - We're Doing Something Different
  • Hello Patient — Healthcare AI that gets your team off the phone & in front of patients
  • Alva Energy — Alva Energy is a nuclear solution based firm that aids challenges related to nuclear power offering on time delivery of nuclear megawatts.
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OrbiMed
VC Fund · New York, New York, United States · 109 investments in United States Biotechnology startups

Leading Global Healthcare Platform with Deep Proprietary Resources and Global Industry Coverage.

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Investment focus

  • Industry: Biotechnology, Health Care, Pharmaceutical
  • Stage:Series B, Series A, Series C
  • Geography: United States, China, Israel

Investor stats

  • Total investments: 767
  • Round size: Series A $9M–$116M; Series B $23M–$148M; Series C $19M–$160M
  • Lead/follow: 35% lead, 65% follow
  • Last fund: Likely actively investing — fresh fund, raised $192M in 2026

Portfolio highlights

  • Windward Bio — Windward Bio is a clinical-stage, drug development company committed to improving outcomes for people living with serious immunological diseases.
  • InventisBio — InventisBio is a biotech company whose product pipeline includes small molecule drug candidates for targeted therapies in lung cancer, breast cancer and gout. The company is also actively developing drugs that can be combined with other immune-oncology targeted therapies, such as PD-1 antibody, for various cancer indications. The company isco-founded by Dr. Yaolin Wang and other scientists who have previously worked at Merck and Schering-Plough, leading various drug discovery projects in oncology, metabolic and infectious disease areas.
  • Bonovo Orthopedics —
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Atlas Venture
VC Fund · Cambridge, Massachusetts, United States · 99 investments in United States Biotechnology startups

Atlas Venture is an early-stage venture capital firm that creates and invests in biotech startup companies led by promising entrepreneurs focusing on life sciences innovation. Its seed-led venture creation strategy rigorously selects and focuses investment on compelling opportunities to build scalable businesses and realize value.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series A, Series B, Seed
  • Geography: United States, United Kingdom, Canada

Investor stats

  • Total investments: 475
  • Round size: Seed $750k–$25M; Series A $4M–$75M; Series B $8M–$115M
  • Lead/follow: 30% lead, 70% follow
  • Last fund: Likely actively investing — fresh fund, raised $400M in 2025

Portfolio highlights

  • E Ink — E Ink Corp. is a supplier of electronic paper display (EPD) technologies. Products made with E Ink's electronic ink are designed to possess a paper-like high contrast appearance, ultra-low power consumption, and a thin, light form. E Ink's technology is tailored for many consumer and industrial applications including handheld devices, watches, clocks, and public information and promotional signs.
  • Songbird — DropCatch.com helps you secure expiring domain names.
  • Ethyreal Bio — Ethyreal Bio is an early-stage biotechnology company developing precision, mechanism-driven therapies for thyroid diseases with high unmet medical needs.
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Google Ventures
VC Fund · Mountain View, California, United States · 93 investments in United States Biotechnology startups

GV supports innovative founders moving the world forward.

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Investment focus

  • Industry: Software, Health Care, Biotechnology
  • Stage:Series A, Series B, Seed
  • Geography: United States, United Kingdom, Israel

Investor stats

  • Total investments: 1518
  • Round size: Seed $1.1M–$15M; Series A $6M–$100M; Series B $15M–$121M
  • Lead/follow: 30% lead, 70% follow
  • Last fund: May invest from a new fund soon — raised $100M in 2014

Portfolio highlights

  • ngmoco — ngmoco ("Next Generation MObile COmpany") is creating and producing games for the iPhone. CEO Neil Young is a former executive from Electronic Arts, where he oversaw the development of several hit titles. Another EA vet and partner at Kleiner Perkins, Bing Gordon, sits on the board. Kleiner is an investor through its iFund.
  • SolveAI —
  • Medallion — Provider credentialing and enrollment reimagined. Accelerate time-to-revenue, stay compliant, and scale provider operations, without adding headcount, through automated credentialing and enrollment.
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New Enterprise Associates
VC Fund · Menlo Park, California, United States · 90 investments in United States Biotechnology startups

Foundational partners to ambitious founders at every stage of company-building.

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Investment focus

  • Industry: Software, Health Care, Biotechnology
  • Stage:Series A, Series B, Series C
  • Geography: United States, China, India

Investor stats

  • Total investments: 2101
  • Round size: Series A $6M–$55M; Series B $10M–$85M; Series C $15M–$100M
  • Lead/follow: 39% lead, 61% follow
  • Last fund: Likely still investing — raised $468M in 2024

Portfolio highlights

  • Zyngenia —
  • Alteon Websystems — Alteon Websystems is a computer network hardware company that provides internet infrastructure solutions enabling e-businesses to meet their increasing demands.  The company’s portfolio of web data center products includes switches, server adapters, and software that are optimized to meet the specific challenges of managing web application trafficand provide high performance network infrastructure solutions.Alteo Websystems was founded in 1996 and is headquartered in San Jose, California.
  • Lithium Technologies — Lithium builds trusted relationships between the world’s best brands and their customers, helping people get answers and share their experiences. Brands like Microsoft, HP, Sephora, Virgin and Barclaycard and customers in more than 34 countries rely on Lithium to help them connect, engage, and understand their total community. With more than 100million monthly visits over all Lithium communities and 750 million online profiles scored by Klout, Lithium has one of the largest digital footprints in the world. Using that data and the company’s software, Lithium customers boost sales, reduce service costs, spark innovation, and build long-term brand loyalty and advocacy.
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Khosla Ventures
VC Fund · Menlo Park, California, United States · 90 investments in United States Biotechnology startups

Khosla Ventures is a venture capital firm that invests in early- to late-stage companies across sectors like AI, healthcare, sustainability, and consumer technology. It manages multiple funds, focusing on startups with innovative technologies or business models. The firm primarily targets sectors like AI, climate tech, digital health, and medtech, offering strategic support to help build long-lasting companies.

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Investment focus

  • Industry: Artificial Intelligence, Software, Health Care
  • Stage:Series A, Seed, Series B
  • Geography: United States, United Kingdom, India

Investor stats

  • Total investments: 1510
  • Round size: Seed $1.7M–$23M; Series A $5.5M–$47M; Series B $11M–$100M
  • Lead/follow: 39% lead, 61% follow
  • Last fund: Likely actively investing — fresh fund, raised $31M in 2026

Portfolio highlights

  • Synchron — The endovascular brain computer interface.
  • LanzaTech — LanzaTech offers a technology platform that transforms industrial waste gases such as carbon monoxide and carbon dioxide into valuable chemical intermediates and fuels through microbial gas fermentation. The company’s process captures emissions from heavy-industry sources and uses specialized microbes to convert those gases into ethanol, which is then refined into materials such as monoethylene glycol for packaging, solvents, proteins, and sustainable aviation fuels. LanzaTech integrates its bioconversion system with industrial emitters, enabling the reuse of carbon streams that would otherwise be released into the atmosphere, and supplies downstream manufacturers in sectors including packaging, textiles, and aviation with fossil-alternative feedstocks.
  • littleBits Electronics — LittleBits is an open source library of over 60 electronic modules that snap together with magnets allows users to view, download, and share designs and make their own Bits through the use of prototypes. Deluxe kit, Smart home kit, Arduino coding kit, Synth kit, hardware development kit, and workshop set are some of the electronics learning modulesprovided by littleBits.LittleBits was launched by Ayah Bdeir in 2011 and is operated from New York, United States.
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Access 48,091 investors

822 industries, 177 countries. Updated daily. Emails and phones included.

Browse database — It's Free!
Polaris Partners
VC Fund · Boston, Massachusetts, United States · 86 investments in United States Biotechnology startups

Polaris Partners invests in healthcare and biotechnology companies. Their healthcare portfolio companies' care delivery models include digital health, consumer-centric businesses, patient-provider solutions, data science, and analytics. Their life sciences and biotechnology portfolio companies focus on molecules and platforms, therapeutics, and genomics.

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Investment focus

  • Industry: Health Care, Biotechnology, Medical
  • Stage:Series B, Series A, Series C
  • Geography: United States, Ireland, Singapore

Investor stats

  • Total investments: 553
  • Round size: Series A $4.6M–$82M; Series B $7.5M–$100M; Series C $10M–$105M
  • Lead/follow: 28% lead, 72% follow
  • Last fund: Likely actively investing — fresh fund, raised $439M in 2025

Portfolio highlights

  • ice — Ice.com is one of the leading e-commerce website that sells diamonds, engagement rings, watches, earrings and all other types of jewelry. It raised $47 million from Polaris Venture Partners and Ignition Partners. The online retailer opened its doors in 1999 and has grown to annual sales of $83.4 million.
  • RetireOne — The outsourced insurance desk of choice for RIAs features low-cost, zero commission annuities for fee-only fiduciaries that are simple + transparent.
  • Cushcraft Corp. — Cushcraft Corp. designs, develops, manufactures, and distributes antennas and other passive radio frequency (RF) products for broadband wireless, communications, and data connectivity solutions.
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RA Capital Management
VC Fund · Boston, Massachusetts, United States · 84 investments in United States Biotechnology startups

RA Capital Management is an investment advisor based in Boston specializing in the life-sciences and drug development sectors. The company's team has been investing since 2002 and is comprised of professionals with training in biology, chemistry, and medicine and also has industry and business development experience at the executive and boardlevels. The company invests in companies with promising technologies and products.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series B, Post-IPO Equity, Series A
  • Geography: United States, United Kingdom, China

Investor stats

  • Total investments: 578
  • Round size: Series A $20M–$128M; Series B $27M–$151M; Post-IPO Equity $35M–$275M
  • Lead/follow: 35% lead, 65% follow
  • Last fund: Likely actively investing — fresh fund, raised $120M in 2025

Portfolio highlights

  • Serapha Bio —
  • Windward Bio — Windward Bio is a clinical-stage, drug development company committed to improving outcomes for people living with serious immunological diseases.
  • Lisata Therapeutics — Lisata is a clinical-stage pharmaceutical company dedicated to improving lives through the discovery, development, and commercialization of innovative medicines.
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Versant Ventures
VC Fund · Menlo Park, California, United States · 79 investments in United States Biotechnology startups

Versant partners with exceptional entrepreneurs to build and fund breakthrough biotechnology companies around the globe.

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Investment focus

  • Industry: Biotechnology, Health Care, Medical
  • Stage:Series A, Series B, Series C
  • Geography: United States, Switzerland, Canada

Investor stats

  • Total investments: 334
  • Round size: Series A $5M–$78M; Series B $12M–$105M; Series C $12M–$107M
  • Lead/follow: 31% lead, 69% follow
  • Last fund: Likely still investing — raised $5M in 2024

Portfolio highlights

  • Inari Medical — Inari Medical is a commercial-stage medical device company focused on developing products to treat and transform the lives of patients suffering from venous diseases. They are focused on treating venous thromboembolism and improving the quality of life of patients suffering from this disease by safely and effectively removing blood clots. It hasdeveloped two minimally-invasive, novel catheter-based mechanical thrombectomy devices that are designed to remove large clots from large vessels and eliminate the need for thrombolytic drugs. The ClotTriever system is 510(k)-cleared by the FDA for thrombectomy in the peripheral vessels and is used to treat patients suffering from deep vein thrombosis. The FlowTriever system is 510(k)-cleared by the FDA for the treatment of pulmonary embolism.The company was founded in 2011 and is headquartered in Irvine, California.
  • Gate Bioscience — Gate Bioscience is developing Molecular Gates, a new frontier in protein elimination. Molecular Gates are small molecule drugs that selectively eliminate harmful extracellular proteins at their origin, inside cells, and prevent them from emerging to cause disease.
  • Dayra Therapeutics — Dayra Therapeutics manufactures peptide based medicines.
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Gaingels
VC Fund · New York, New York, United States · 79 investments in United States Biotechnology startups, 76 in the past 12 months

Gaingels is a venture investment syndicate in service of the LGBT+ community and its allies, investing in companies with LGBT+ founders and C-suite leaders at all stages of growth, as well as in more established companies resolved on building more inclusive teams, with a global portfolio of 130+ companies and $70M in deployed investment capital to date.  The Gaingels network also actively supports its portfolio in identifying and recruiting diverse talent to their C-suite and board leadership teams and fosters a vibrant global community of industry leaders, investors, operators, and entrepreneurs who share a common goal for positive social change through business and successful investments.

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Investment focus

  • Industry: Software, Artificial Intelligence, Health Care
  • Stage:Seed, Series A, Venture - Series Unknown
  • Geography: United States, Canada, United Kingdom

Investor stats

  • Total investments: 1354
  • Round size: Seed $1M–$8.1M; Series A $5M–$35M; Venture - Series Unknown $72k–$13M
  • Lead/follow: 1% lead, 99% follow
  • Last fund: Likely actively investing — fresh fund, raised $140k in 2026

Portfolio highlights

  • Allara — Allara is your all-in-one virtual care team for hormonal, metabolic & gynecological conditions such as PCOS and Endometriosis.
  • North.cloud — Automate your enterprise-grade cloud finance with zero effort. Our AI reduces your cloud bill by 50% without any risk, contracts, or technical work.
  • Uvi — Uvi provides infrastructure that serves as a context and reasoning layer for enterprise AI agents. The platform resolves internal corporate vocabulary, tracks dependencies, and reconstructs the decision-making intent scattered across disparate systems like Jira, GitHub, and Slack. By unifying data fragments into an integrated knowledge network, it enables AI tools to process query objectives accurately while enforcing existing user access permissions at the retrieval stage.
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F-Prime
VC Fund · Cambridge, Massachusetts, United States · 78 investments in United States Biotechnology startups

F-Prime Capital is a global venture capital firm investing in healthcare and technology, with a heritage that spans four decades.

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Investment focus

  • Industry: Health Care, Biotechnology, Medical
  • Stage:Series A, Series B, Seed
  • Geography: United States, China, United Kingdom

Investor stats

  • Total investments: 548
  • Round size: Seed $1.6M–$20M; Series A $8M–$87M; Series B $15M–$112M
  • Lead/follow: 25% lead, 75% follow

Portfolio highlights

  • Innovent Biologics — Innovent Biologics, Inc. is a privately held biopharmaceutical company that is dedicated to the development and manufacturing of monoclonal antibodies to be marketed in China and elsewhere around the world. Innovent is funded by the venture arm of Fidelity, which is a major investment firm in the US, Lilly Ventures, and Suzhou bioBay. Theregistered capital is 30Million US Dollars. The founders and senior management team of Innovent have over 70 years of combined work experience in the discovery, development and manufacture of biologics in the US, Europe and worldwide and were involved in the launch of such products as Bexxar, Conbercept, Natrecor, Oncorine, Recombivax HB, and others.
  • Mersana Therapeutics — Discover how Day One is disrupting the status quo of traditional drug development to bring new medicines to children and adults with cancer.
  • PlasmaGen Biosciences — PlasmaGen BioSciences is an Indian Bio-pharmaceutical organization specializing exclusively in Plasma Protein Therapy.Headquartered in Bangalore- India, PlasmaGen has been making every effort in the domain of Plasma product Industry and has become an Imperative one stop destination for the medical fraternity for most of the plasma products need.They have a basket of plasma products and the widest range of immunoglobulins in India catering to the requisites of various realms viz. Haematology, Oncology, Immunology, Paediatrics, Rheumatology, Dermatology and Neurology.
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Third Rock Ventures
VC Fund · Boston, Massachusetts, United States · 78 investments in United States Biotechnology startups

Third Rock Ventures invests in transformational life science companies that show high growth potential and are well-positioned to make a difference in the marketplace. Third Rock Ventures believes in the companies we start and makes significant initial investments, which are frequently supplemented by strategic collaborations, to help our firms progress in life-changing medicines, technologies, and diagnostics.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series A, Series B, Series C
  • Geography: United States, Japan, Israel

Investor stats

  • Total investments: 179
  • Round size: Series A $19M–$110M; Series B $11M–$190M; Series C $20M–$108M
  • Lead/follow: 46% lead, 54% follow
  • Last fund: Likely still investing — raised $1.1B in 2022

Portfolio highlights

  • CytomX Therapeutics — CytomX Therapeutics is a biotechnology company that focuses on developing proteolytically-activated antibodies. Their mission, alone and with the help of partners, is to provide patients with more effective and less toxic therapies for severe illnesses such as cancer and inflammatory diseases.
  • Jounce Therapeutics — Concentra is a biosciences company.
  • Lisata Therapeutics — Lisata is a clinical-stage pharmaceutical company dedicated to improving lives through the discovery, development, and commercialization of innovative medicines.
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Andreessen Horowitz
VC Fund · Menlo Park, California, United States · 70 investments in United States Biotechnology startups

Andreessen Horowitz (a16z) is a venture capital firm in Silicon Valley, California, investing in bold founders, innovators, and entrepreneurs building the future through technology.

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Investment focus

  • Industry: Software, Artificial Intelligence, Information Technology
  • Stage:Series A, Seed, Series B
  • Geography: United States, United Kingdom, Canada

Investor stats

  • Total investments: 2145
  • Round size: Seed $1.5M–$16M; Series A $9M–$55M; Series B $17M–$120M
  • Lead/follow: 49% lead, 51% follow
  • Last fund: Likely actively investing — fresh fund, raised $1.2B in 2026

Portfolio highlights

  • Tennr — Tennr is a custom AI assistant that accelerates research, answers complex questions, and generates custom reports.
  • Stoïk — Stoïk is a cyber insurance company that integrates cybersecurity software with insurance protection, helping businesses manage their cyber risks effectively. Stoïk empowers brokers by offering clients comprehensive insurance policies and protection against cyber risks. Its mission is to equip brokers with the tools to help their clients insure andsafeguard against cyber threats.Stoïk's unique product simplifies the underwriting process using automated tests, replacing traditional questionnaires. It also provides continuous risk prevention through integrated cybersecurity tools and ensures swift, effective incident response with an in-house team of crisis management experts.
  • Supersonik — Supersonik provides an AI-powered platform for SaaS companies to offer 24/7 interactive product demos, enabling prospects to explore and personalize demos instantly without scheduling or manual intervention.
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5AM Ventures
VC Fund · Menlo Park, California, United States · 68 investments in United States Biotechnology startups

5AM Ventures is a venture capital firm that offers seed- and early-stage investments to its clients. The company’s client portfolio consists of firms in the biopharmaceutical, life sciences, medical technology, and research instrument industries. 5AM Ventures was founded in 2002 by John Diekman and Andrew Schwab and is based in California.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series A, Series B, Series C
  • Geography: United States, Switzerland, United Kingdom

Investor stats

  • Total investments: 198
  • Round size: Series A $13M–$70M; Series B $15M–$110M; Series C $14M–$105M
  • Lead/follow: 37% lead, 63% follow
  • Last fund: Likely still investing — raised $450M in 2022

Portfolio highlights

  • Relypsa — Relypsa, Inc. is a privately-held, development stage biopharmaceutical company leading the discovery and development of novel non-absorbed polymeric drugs for important applications in cardiovascular and renal disease. Relypsa's lead product candidate is RLY5016, a non-absorbed potassium binder for the management of hyperkalemia. Relypsa isdedicated to discover additional product candidates through use of its proprietary polymer platform.
  • Skye Bioscience — We are a biopharmaceutical company focused on the development of proprietary cannabinoid derivatives for the treatment of glaucoma and other diseases with significant unmet medical needs. Our innovative approach to drug development combines strong science with the drive to find solutions where the need is the greatest.
  • ALX Oncology — ALX Oncology is a preclinical stage biotechnology company developing innovative immuno-oncology therapies for cancer. It is an independent, private biotechnology company.The founding of Alexo Therapeutics was based upon technology invented by Aaron Ring, K. Christopher Garcia, Kipp Weiskopf, Aron Levin, and Irving Weissman at Stanford University.This discovery involves soluble versions of signal regulatory protein-α (SIRPα) that have been engineered to bind CD47 with significantly greater affinity than natural SIRPα.1.
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MPM Capital
VC Fund · Cambridge, Massachusetts, United States · 67 investments in United States Biotechnology startups

Powering Breakthroughs in Life Sciences

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series B, Series A, Series C
  • Geography: United States, Canada, United Kingdom

Investor stats

  • Total investments: 241
  • Round size: Series A $10M–$80M; Series B $20M–$116M; Series C $12M–$109M
  • Lead/follow: 35% lead, 65% follow
  • Last fund: Likely still investing — raised $850M in 2021

Portfolio highlights

  • Orna Therapeutics — Orna Therapeutics is a biotechnology company dedicated to designing and delivering a new class of fully engineered circular RNA (oRNA) therapeutics with the potential to change the way we treat disease. Orna’s proprietary platform combines novel technology to create oRNAs that drive protein expression with validated and unique delivery solutions.
  • Aratana Therapeutics — Aratana is uniquely positioned to deliver new, high-quality medicines to address unmet needs in companion animal care. We are committed to bringing world class science to animal health for companion animals and the people who care for them. Our competitive advantage resides in our ability to identify, acquire and develop high-value commercialproducts for companion animals in a cost effective and efficient manner.
  • Rhythm Pharmaceuticals — Rhythm Pharmaceuticals is a global biopharmaceutical company committed to transforming the lives of patients with rare neuroendocrine diseases by rapidly advancing care and precision medicines that address the root cause.
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Innova Memphis
VC Fund · Memphis, Tennessee, United States · 66 investments in United States Biotechnology startups

Innova operates an early-stage venture capital fund specifically targeting the agricultural technology and farm management sectors. The firm provides pre-seed, seed, and series-A financial deployments alongside strategic scaling guidance to startups addressing agricultural biological inputs, automated labor robotics, on-farm data capture systems, and decision-support analytics. Its value proposition centers on supplying crucial initial institutional check liquidity to founders to build economically transformative tools that optimize farmer profitability and backend operation workflows. At Innova we invest in start-up companies, help them grow, and then assist them in linking with established corporations for licensing, buy-outs or further investments. We provide the synergy of experienced management, market expertise and venture capital to accelerate the development of new products and services into viable business units that can stand on their own and then take their place with a mature market leader, if desired. Whether an innovation is still on the drawing board or stalled in the market place the Innova staff has the expertise, skills, and experience to envision and create a functioning business unit that is prepared to thrive in the market place. Technical know-how, market-proven staffing, and "just-right" funding assure the greatest chance possible for success.

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Investment focus

  • Industry: Health Care, Medical, Medical Device
  • Stage:Seed, Pre-Seed, Convertible Note
  • Geography: United States, Germany, Argentina

Investor stats

  • Total investments: 292
  • Round size: Seed $25k–$1.5M; Pre-Seed $25k–$1.3M; Convertible Note $48k–$1.4M
  • Lead/follow: 25% lead, 75% follow
  • Last fund: Likely still investing — raised $40M in 2023

Portfolio highlights

  • HerdDogg — HerdDogg is a global herd health and data science platform. It is a two-part system that helps ranchers track health and proximity data from their herd. The company's device gathers the data captured by the ear tags and reports it directly to the rancher via an app or web database.
  • Insignum AgTech — Insignum AgTech develops biotech plants that communicate with producers, alerting them to an illness in its early stages.
  • Soiltech Wireless — Soiltech Wireless is a developer of ag-tech solutions to design electronic devices for agricultural professionals. Its product provides real-time data to drive efficiency and optimize quality. It also provides actionable data without installation hassles and creates scalable monitoring solutions for farmers.The company was founded in 2019 and isheadquartered in Rupert, Idaho.
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Fifty Years
VC Fund · San Francisco, California, United States · 62 investments in United States Biotechnology startups, 6 in the past 12 months

WE BACK HEROES using technology to solve the world's biggest problems

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Investment focus

  • Industry: Biotechnology, Health Care, Artificial Intelligence
  • Stage:Seed, Series A, Pre-Seed
  • Geography: United States, Germany, Canada

Investor stats

  • Total investments: 216
  • Round size: Seed $2M–$13M; Pre-Seed $572k–$3.3M; Series A $8.5M–$40M
  • Lead/follow: 17% lead, 83% follow
  • Last fund: Likely still investing — raised $90M in 2021

Portfolio highlights

  • Wafer — Wafer is an AI optimization platform that automatically accelerates AI models by generating efficient custom GPU kernels.
  • Adaption Labs — Adaption is building adaptive intelligence that continually learns. Efficient, evolving AI for any industry or language.
  • Multiply Labs — Multiply Labs develops robotic systems that manufacture small-batch drugs. Current pharma production methods are manual, slow, and costly. We believe that the only way to scale them is with cloud-controlled robots.
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Canaan Partners
VC Fund · Menlo Park, California, United States · 61 investments in United States Biotechnology startups

Canaan is an early stage venture capital firm that invests in entrepreneurs with visionary ideas. With $5B under management, a diversified fund and over 190 exits to date, Canaan has invested in some of the world's leading technology and healthcare companies over the past 30 years. Canaan’s focus areas include fintech, enterprise/cloud, marketplaces, frontier tech, biopharma, digital health, and medtech.

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Investment focus

  • Industry: Software, Biotechnology, Health Care
  • Stage:Series A, Series B, Seed
  • Geography: United States, Israel, United Kingdom

Investor stats

  • Total investments: 786
  • Round size: Seed $1.8M–$10M; Series A $5.5M–$45M; Series B $8M–$75M
  • Lead/follow: 33% lead, 67% follow
  • Last fund: Likely still investing — raised $100M in 2024

Portfolio highlights

  • p°Motion — p°Motion provides precision biomechanics and intelligent data science to decode human physical tracking data. The core business model leverages body angle mechanics to pinpoint joint constraints, motion strains, and continuous postural imbalances before they result in injuries. This system delivers tailored, sport-specific corrective programming designed to maximize physical recovery, increase overall output, and build personal physical longevity.
  • Diligent Robotics — We build robots like Moxi that assist hospital staff with routine activities so they can focus on caring for patients.
  • GroundWork — GroundWork delivers Unified Monitoring for Real™ with an open software platform for shockingly easy integrations and customized visualizations of cloud, virtualization, network, application, server, and storage data.GroundWork Monitor is available in free (Core) and subscription versions with support (Enterprise).GroundWork was founded in 2004 andis headquartered in San Francisco, California with partners in Asia Pacific, Europe and South America.
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Lux Capital
VC Fund · New York, New York, United States · 58 investments in United States Biotechnology startups

Lux Capital focuses on sectors such as artificial intelligence, biotechnology, advanced materials, space, and energy, backing businesses that apply scientific research to commercial applications. It provides capital alongside strategic input on product development, company building, and long-term positioning. The firm works with technical founders and research-driven teams to translate complex innovations into scalable businesses. It evaluates opportunities based on the underlying science, potential for industry impact, and feasibility of execution over extended time horizons.

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Investment focus

  • Industry: Software, Artificial Intelligence, Health Care
  • Stage:Series A, Seed, Series B
  • Geography: United States, United Kingdom, Canada

Investor stats

  • Total investments: 706
  • Round size: Seed $1.6M–$25M; Series A $7M–$90M; Series B $13M–$150M
  • Lead/follow: 28% lead, 72% follow
  • Last fund: Likely actively investing — fresh fund, raised $10M in 2026

Portfolio highlights

  • Adimab — Premier Human Antibody Discovery and Optimization
  • Modal Labs — Modal develops machine learning software to help run code in the cloud. The software enables users to run or deploy machine learning models, massively parallel compute jobs, task queues, web apps, and more. It also writes the code to launch hundreds of custom containers and runs scripts in the cloud faster than on the local machine.
  • Cajal Neuroscience — Cajal Neuroscience is a drug discovery company focused on neurodegenerative disease.
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DCVC
VC Fund · San Francisco, California, United States · 57 investments in United States Biotechnology startups

We are deep tech venture capital.

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Investment focus

  • Industry: Software, Artificial Intelligence, Machine Learning
  • Stage:Seed, Series A, Series B
  • Geography: United States, United Kingdom, Canada

Investor stats

  • Total investments: 519
  • Round size: Seed $1M–$9.1M; Series A $6M–$50M; Series B $15M–$130M
  • Lead/follow: 23% lead, 77% follow
  • Last fund: Likely actively investing — fresh fund, raised $5M in 2026

Portfolio highlights

  • CH4 Global — CH4 Global is an aquaculture solutions provider dedicated to urgently impacting climate change at scale. Lead by a world-class team of senior business builders, scientists and entrepreneurs, the company is initially leveraging proven science and technology for growing seaweed into innovative new livestock supplement that reduces methane produced bycows by up to 90%. Among early investors are a select group of prominent family offices and private investors. CH4 Global have also received non-dilutive capital support from government organizations from around the world. CH4 Global is a Delaware corporation based in Henderson, NV.
  • TypeSafe AI — TypeSafe AI develops artificial intelligence models and software tools designed to support automated decision-making within applications and business workflows. Its primary product, Jev, is a System One Model that processes structured questions and returns typed decisions accompanied by probability scores and confidence estimates. These outputs help software systems perform tasks such as classification, scoring, routing, content evaluation, and customer service operations. TypeSafe AI provides an application programming interface and a web-based console that enable developers and organizations to integrate Jev into their existing systems. Its technology uses a training approach called Reinforcement Learning for Calibrated Decisions, which focuses on producing decisions that software can interpret and apply directly. The platform also supports configurable confidence thresholds, allowing applications to automate actions when confidence meets defined criteria or direct uncertain cases for human review. Through these capabilities, TypeSafe AI focuses on making AI-driven decisions usable in structured, programmatic workflows.
  • Universal Quantum — Universal Quantum is building quantum computers to tackle real-world problems that would take today’s fastest supercomputers billions of years to solve.
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Liquid 2 Ventures
VC Fund · San Francisco, California, United States · 54 investments in United States Biotechnology startups

Liquid 2 Ventures is a venture capital firm that invests in early-stage startups, primarily at the pre-seed and seed stages. It provides capital, founder guidance, operational support, and access to a network of entrepreneurs, investors, and industry contacts.

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Investment focus

  • Industry: Software, Artificial Intelligence, Information Technology
  • Stage:Seed, Pre-Seed, Series A
  • Geography: United States, Mexico, Canada

Investor stats

  • Total investments: 1249
  • Round size: Seed $1.1M–$9.1M; Pre-Seed $125k–$2.7M; Series A $6M–$48M
  • Lead/follow: 1% lead, 99% follow
  • Last fund: Likely actively investing — fresh fund, raised $12M in 2026

Portfolio highlights

  • Albedo — Aerial quality imagery - from space.
  • Hilt — Govern data movement in real time. Kernel-level telemetry and anomaly detection built for environments where traditional security tools fall short.
  • Eden — Eden unifies medical imaging operations with clinical AI: PACS, teleradiology, AI-assisted diagnosis and structured reporting, deployed across 2,600+ imaging departments.
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The Column Group
VC Fund · San Francisco, California, United States · 53 investments in United States Biotechnology startups, 12 in the past 12 months

The Column Group (TCG) is a venture ecosystem dedicated to fueling scientific innovation in the life sciences industry.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series A, Series B, Series C
  • Geography: United States

Investor stats

  • Total investments: 165
  • Round size: Series A $15M–$102M; Series B $22M–$120M; Series C $37M–$120M
  • Lead/follow: 38% lead, 62% follow
  • Last fund: Likely still investing — raised $100M in 2024

Portfolio highlights

  • Kallyope — At TriGemX Bio, we are leveraging unique insights into neural signaling pathways and developing innovative medicines for the treatment of migraine.
  • InduPro — InduPro is a biotechnology company that specializes in protein therapeutics and cell-surface platform technologies.
  • Circle Pharma — Circle Pharma is an early-stage biotechnology company applying proprietary computational design algorithms and innovative chemistry to develop cell-permeable macrocycle peptide therapeutics against important clinical targets. It does this through an iterative, rational design process that deploys large virtual libraries of conformationally diversemacrocycle scaffolds selected for inherent permeability. The company was founded by Matt Jacobson and Scott Lokey in 2012 and is headed by David J. Earp.
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Connecticut Innovations
VC Fund · Rocky Hill, Connecticut, United States · 51 investments in United States Biotechnology startups

At Connecticut Innovations, we see venture capital the way you see your business. Like no one else. We invest in innovative biotech, IT, and other industries.

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Investment focus

  • Industry: Health Care, Biotechnology, Software
  • Stage:Seed, Series A, Series B
  • Geography: United States, Israel, Canada

Investor stats

  • Total investments: 315
  • Round size: Seed $150k–$5.3M; Series A $1.8M–$25M; Series B $1.8M–$75M
  • Lead/follow: 30% lead, 70% follow
  • Last fund: Likely still investing — raised $50M in 2023

Portfolio highlights

  • CloudSEK — CloudSEK leverages contextual AI to predict and prevent cyber threats. Keep your organisation safe and secure.
  • NovaTract Surgical — NovaTract Surgical is a development stage company, intends to develop medical devices to address the rapidly growing field of Single Incision Laparoscopic Surgery (SILS) and Natural Orifice Transluminal Endoscopic Surgery (NOTES). The company was incorporated in 2010 and is based in Guilford, Connecticut.
  • Axerion Therapeutics — Axerion Therapeutics, Inc. is a private Connecticut-based biotechnology company focused on developing innovative therapeutics for neurological diseases and injuries with significant unmet medical need, including Alzheimer’s disease and spinal cord injury.Axerion was established in New Haven to develop and commercialize intellectual propertylicensed from Dr. Stephen Strittmatter’s laboratory at Yale University. Axerion’s proprietary technology platforms include blockers of ß-amyloid (Aß) oligomers binding to Prion Proteins (PrP) on the cell surface of neurons as a novel therapeutic target for Alzheimer’s disease and Nogo Receptor decoy protein for recovery of neurological function in spinal cord injury and other neurological diseases.
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KdT Ventures
VC Fund · Austin, Texas, United States · 50 investments in United States Biotechnology startups

KdT Ventures is the standard for early-stage frontier science investing.

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Investment focus

  • Industry: Biotechnology, Health Care, Medical
  • Stage:Seed, Series A, Series B
  • Geography: United States, India, Canada

Investor stats

  • Total investments: 96
  • Round size: Seed $2.6M–$13M; Series A $9M–$70M; Series B $25M–$175M
  • Lead/follow: 9% lead, 91% follow
  • Last fund: Likely actively investing — fresh fund, raised $4.9M in 2026

Portfolio highlights

  • Zag Bio — Zag Bio is harnessing the immune system in a whole new way by targeting the thymus to change treatment possibilities for millions of patients with autoimmune diseases.
  • Skeletalis — Skeletalis is a biotechnology startup focused on developing next-generation precision medicines for musculoskeletal diseases, primarily osteoporosis.
  • Tacit Therapeutics — Tacit Therapeutics created RNA-targeting treatments for devastating diseases. By repurposing pre-existing components of human cells, we have created the first broadly applicable and inherently non-immunogenic means to repair mutated genes. The company was founded in 2021 and is based in South San Francisco, California.
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BioAdvance
VC Fund · Philadelphia, Pennsylvania, United States · 50 investments in United States Biotechnology startups

BioAdvance actively invests venture capital in therapies, medical devices, research tools, diagnostics and health IT in the Mid-Atlantic region.

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Investment focus

  • Industry: Biotechnology, Health Care, Medical
  • Stage:Seed, Series A
  • Geography: United States, Canada

Investor stats

  • Total investments: 127
  • Round size: Seed $350k–$3M; Series A $1.5M–$40M
  • Lead/follow: 13% lead, 87% follow
  • Last fund: May invest from a new fund soon — raised $20M in 2002

Portfolio highlights

  • Latus Bio — Latus Bio focuses on developing innovative gene therapy candidates using precision delivery to enhance the lives of patients. Latus identified proprietary AAV capsids for clinical use. The company plans to administer low doses of its product candidates, aiming to improve clinical safety and manufacturing.
  • Overwatch Health — Overwatch Health offers an AI-assisted virtual rehab for cardiac and pulmonary patients.
  • Palvella Therapeutics — Palvella Therapeutics is a biopharmaceutical company focused on developing and commercializing novel therapies to treat patients living with serious, rare skin diseases and vascular anomalies for which there are no FDA-approved therapies.
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Apple Tree Partners
VC Fund · New York, New York, United States · 49 investments in United States Biotechnology startups

ATP, a global leader in life sciences venture capital, is developing the next generation of transformative biotechnology companies. ATP creates science-based companies starting with assets at various stages: from working with scientists on pre-IP ideas, to spinouts from existing company pipelines. The firm provides flexible capital, strategic insight, and operational resources to build sustainable, research-driven enterprises. ATP invests in its portfolio companies from seed stage through IPO and beyond and supports their management teams in strategic transactions and synergistic business combinations.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series A, Series B, Seed
  • Geography: United States, Canada, United Kingdom

Investor stats

  • Total investments: 100
  • Round size: Seed $3.5M–$8M; Series A $15M–$75M; Series B $29M–$100M
  • Lead/follow: 63% lead, 37% follow
  • Last fund: May invest from a new fund soon — raised $1B in 2020

Portfolio highlights

  • Ascidian Therapeutics — Ascidian Therapeutics is a biotechnology company intended for medical use in medical and clinical gene therapy.
  • Red Queen Therapeutics — Staying ahead of viral threats with new innovations in antiviral therapy
  • Deep Apple Therapeutics — Deep Apple Therapeutics is discovering new small-molecule therapeutics with unprecedented speed and exceptional acumen.
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8VC
VC Fund · San Francisco, California, United States · 48 investments in United States Biotechnology startups

8VC focuses its investment activities on industries such as life sciences, healthcare, logistics, manufacturing, enterprise software, and defense. Its portfolio support model aids founders in scaling transformational technologies intended to create long-term economic and societal value. The firm actively finances breakthroughs ranging from medical innovations and zero-emission transit models to security compliance and infrastructure automation.

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Investment focus

  • Industry: Software, Artificial Intelligence, Health Care
  • Stage:Seed, Series A, Series B
  • Geography: United States, United Kingdom, Canada

Investor stats

  • Total investments: 678
  • Round size: Seed $2.5M–$13M; Series A $7.7M–$55M; Series B $17M–$181M
  • Lead/follow: 32% lead, 68% follow
  • Last fund: Likely actively investing — fresh fund, raised $45M in 2026

Portfolio highlights

  • Harbor — Harbor is a specialized platform designed to provide insurance and risk management for the AI agentic economy. As AI agents increasingly take over autonomous decision-making tasks within enterprise environments, they introduce unique operational, security, and regulatory risks that traditional safety controls are not built to handle.
  • Hello Patient — Healthcare AI that gets your team off the phone & in front of patients
  • Sirona Medical — Sirona Medical is revolutionizing radiology by delivering a cloud-native platform that unifies the worklist, viewer, reporter, archive, and AI into a single, intuitive workspace. Designed specifically for radiologists, Sirona’s platform simplifies complex workflows, enhances productivity, and empowers practitioners to work as fast as they think.Founded in San Francisco, CA, Sirona combines deep expertise in the practice and business of radiology to create purpose-built solutions that address the evolving needs of the field. By streamlining radiology workflows and integrating cutting-edge AI, Sirona enables radiologists to deliver better, faster, and more efficient care.
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Novartis Venture Fund
VC Fund · Basel, Basel-Stadt, Switzerland · 47 investments in United States Biotechnology startups

Learn about the approach the Novartis Venture Fund takes to investing in innovative life science companies developing biotechnology and biopharmaceutical therapeutics that address unmet patient needs.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series B, Series A, Series C
  • Geography: United States, Switzerland, United Kingdom

Investor stats

  • Total investments: 237
  • Round size: Series A $5.1M–$81M; Series B $11M–$107M; Series C $9M–$75M
  • Lead/follow: 25% lead, 75% follow
  • Last fund: May invest from a new fund soon — raised $200M in 2009

Portfolio highlights

  • Kynexis — Kynexis is leading the way in precision medicine, focusing on the treatment of cognitive impairment associated with schizophrenia (CIAS). Explore our innovative approach and our dedication to improving the lives of millions globally.
  • Visiogen — Visiogen, Inc. is an ophthalmic medical device company specializing in the development of new vision alternatives for patients with cataracts, with and without presbyopia. As part of this mission, Visiogen created the Synchrony dual optic accommodating *intraocular lens (IOL)* for use in the surgical treatment of these conditions.The device isdesigned to provide patients with near, intermediate and distance vision in a seamless continuum without the need for glasses or contact lenses. To eliminate lens handling during surgery, the Synchrony dual optic IOL is provided in a pre-loaded injector. This patented technology has been approved in Europe with a CE Mark designation and is currently undergoing clinical trials in the United States.
  • Rein Therapeutics — Rein Therapeutics is advancing a novel pipeline of first-in-class medicines to address unmet medical needs in orphan pulmonary and fibrosis indications.
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TCA Venture Group
VC Fund · Newport Beach, California, United States · 47 investments in United States Biotechnology startups

TCA Venture Group is the largest angel investor group in the United States, possessing more than 300 members in five networks in Los Angeles, Orange County, San Diego, Central Coast, and the Inland Empire. Its members provide funding and guidance to more early-stage, high-growth companies in Southern California than any other investment group. Members invest in companies in a wide range of industries, including the life sciences, biotech, IT, services, retail, Internet, financial, software, media, consumer products, and tech startups. TCA as a whole gives companies more than just capital; they also provide counsel, mentoring, and access to an extensive network of potential investors, customers, strategic partners, and management talent. Tech Coast Angels has been ranked by CB Insights to be among the Top 20 Angel Groups in the US; TCA was also ranked as #1 for Network Centrality, meaning we have more connections than anyone! If you are in the game-changing business, we are here to help.

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Investment focus

  • Industry: Health Care, Software, Biotechnology
  • Stage:Seed, Venture - Series Unknown, Convertible Note
  • Geography: United States, Canada, South Africa

Investor stats

  • Total investments: 396
  • Round size: Seed $525k–$3.8M; Convertible Note $50k–$4.5M; Venture - Series Unknown $400k–$8.5M
  • Lead/follow: 9% lead, 91% follow
  • Last fund: May invest from a new fund soon — last raise in 2015

Portfolio highlights

  • EdgeX — Edokonta builds software that allows hospitals to track mobile equipment, such as IV pumps and ultrasounds. The company was founded in 2018 and based in San Diego, California.
  • Nested Knowledge — Nested Knowledge is designing an interface that allows you to examine the data from a comprehensive literature review on research questions of interest. The interactive, nested features facilitate therapeutic comparisons, assist with research organization, and allow physicians to compare nuances across patient characteristics and outcomes.
  • Major Medical Devices — Major Medical Devices develops next-generation vascular devices for endovascular repair and related surgical procedures.
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Founders Fund
VC Fund · San Francisco, California, United States · 46 investments in United States Biotechnology startups

Founders Fund is a San Francisco based venture capital firm investing in companies building revolutionary technologies.

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Investment focus

  • Industry: Software, Artificial Intelligence, Health Care
  • Stage:Series A, Seed, Series B
  • Geography: United States, United Kingdom, Germany

Investor stats

  • Total investments: 1069
  • Round size: Seed $1.7M–$14M; Series A $5.5M–$50M; Series B $15M–$100M
  • Lead/follow: 33% lead, 67% follow
  • Last fund: Likely actively investing — fresh fund, raised $6B in 2026

Portfolio highlights

  • Quantcast — We are taking an entirely new approach to advertising on the open internet.
  • Anvil — Anvil provides a decentralized finance protocol that enables users and applications to manage collateral and issue credit backed by digital assets. The platform offers a secure vault for holding collateral and tooling for allocating assets into collateral pools. Anvil supports creation and management of onchain letters of credit as fully secured financial guarantees for different applications. Users interact with the protocol through a web interface that connects to their digital wallets and relevant smart contracts. The protocol is intended for organizations and individuals seeking predictable, programmable credit arrangements and collateralized transactions in onchain finance.
  • Ramp — Join thousands of forward-thinking businesses using Ramp to control spend, save time, and automate busywork.
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Sand Hill Angels
VC Fund · Mountain View, California, United States · 46 investments in United States Biotechnology startups

For over two decades, Sand Hill Angels has worked openly and collaboratively with venture capital funds, other angel organizations, and the Bay Area ecosystem that fosters the growth of technology startups.

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Investment focus

  • Industry: Software, Health Care, Biotechnology
  • Stage:Seed, Convertible Note, Series A
  • Geography: United States, Canada, India

Investor stats

  • Total investments: 615
  • Round size: Seed $1M–$6M; Series A $1.6M–$20M; Convertible Note $300k–$25M
  • Lead/follow: 2% lead, 98% follow

Portfolio highlights

  • PlusPlus — PlusPlus provides a learning and development SaaS platform for technical professionals. It automates the management of onboarding, workshops, and tech-talks at scale. With PlusPlus, companies attract and develop employees.
  • Clean Power Finance — Clean Power Finance (CPF) is building an online business-to-business marketplace to drive the mass-market adoption of solar. The company connects providers of capital who are committed to investing in residential solar with qualified solar marketers, installers and distributors who need residential solar finance products to differentiate and growtheir businesses. CPF raises 100 percent third-party‐owned project finance funds from institutional investors such as Morgan Stanley and Google, working with the investors to structure and launch the funds with managed risk and return profiles. CPF then markets the funds as solar leases and power purchase agreements (PPAs) to qualified solar professionals, including Paramount Solar and Real Goods Solar (Nasdaq: RSOL), through its licensed online solar sales platform, CPF Tools. CPF Tools is software-as-a-service that simplifies complex sales, quoting, proposal and finance processes and minimizes the “soft costs” of selling solar.CPF’s fund investors earn favorable returns on stable investments on the resulting portfolios of residential distributed generation projects. The company’s solar professional partners gain access to solar leases and power purchase agreements (PPAs) that they can brand and sell to homeowners who want the benefits of solar without the cost and hassle of owning and maintaining a system.CPF manages approximately half a billion dollars of capacity on behalf of fund investors, and supports more than 100 solar professional customers who currently use the CPF Market to sell residential solar finance products to homeowners in CA, CO, HI, MA and NJ. Thousands of solar professionals in all 50 states have extensively used CPF Tools to quote and design solar systems.
  • Magnetic Insight — Magnetic Insight (MI) introduced magnetic particle imaging into the preclinical diagnostic research market enabling quantitative cell tracking, imaging of vascular function, detecting metastatic tumors, visualizing inflammation, CAR-T cell therapies and initial research into regenerative medicine.
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Deerfield
VC Fund · New York, New York, United States · 46 investments in United States Biotechnology startups

Deerfield is an investment firm dedicated to advancing healthcare through investment, intelligence, and philanthropy. We work across the healthcare ecosystem, connecting people, capital, ideas, and technology in new and often unexpected ways.

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Investment focus

  • Industry: Health Care, Biotechnology, Medical
  • Stage:Series A, Series C, Venture - Series Unknown
  • Geography: United States, United Kingdom, Canada

Investor stats

  • Total investments: 294
  • Round size: Series A $11M–$67M; Series C $20M–$110M; Venture - Series Unknown $3M–$120M
  • Lead/follow: 43% lead, 57% follow
  • Last fund: Likely actively investing — fresh fund, raised $600M in 2025

Portfolio highlights

  • Neomorph — We engineer neomorphic protein surfaces to unlock targeted protein degradation.
  • Axon Therapies — Axon is pioneering a frontline therapy that leverages Splanchnic Ablation for Volume Management (SAVM) to treat a root cause of heart failure.
  • SHINE Technologies — Discover SHINE Technologies' innovative approach to fusion technology, producing medical isotopes, recycling nuclear waste, and generating energy.
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Pfizer Venture Investments
VC Fund · New York, New York, United States · 46 investments in United States Biotechnology startups

Pfizer Venture Investments is a corporate venture capital firm that invests in areas of current or future strategic interest to Pfizer. It aims to remain at the forefront of life science advances. It identifies and invests in emerging companies that are developing transformative medicines and technologies that have the potential to enhance Pfizer’s pipeline and shape the future of its industry.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series B, Series A, Series C
  • Geography: United States, United Kingdom, Switzerland

Investor stats

  • Total investments: 188
  • Round size: Series A $12M–$100M; Series B $20M–$120M; Series C $15M–$102M
  • Lead/follow: 27% lead, 73% follow
  • Last fund: May invest from a new fund soon — raised $600M in 2018

Portfolio highlights

  • Flare Therapeutics — Flare Therapeutics is a biotechnology company opening up a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders, Flare’s team has uncovered ‘switch sites,’ druggable regions that are key targets fortranscription factor regulation to address mutations that cause disease. Its drug discovery to target switch sites has rapidly advanced, resulting in an emerging pipeline of drug programs that address well-validated transcription factors, initially focused on precision oncology with future potential in neurology, rare genetic disorders, immunology, and inflammation.
  • Flexion Therapeutics — Flexion Therapeutics advances drug candidates through clinical proof of concept and beyond, in partnership with pharmaceutical and biotechnology companies. By providing expertise and sharing risk, Flexion effectively expands the portfolios of its partners.
  • TwoStep Therapeutics — TwoStep Therapeutics is developing novel tumor-targeting therapeutics for solid tumors.
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Omega Funds
VC Fund · Boston, Massachusetts, United States · 45 investments in United States Biotechnology startups

We aim to invest in exceptional founders and entrepreneurs and impactful products and platforms across multiple therapeutic areas.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series A, Series B, Series C
  • Geography: United States, Switzerland, United Kingdom

Investor stats

  • Total investments: 172
  • Round size: Series A $16M–$200M; Series B $38M–$165M; Series C $14M–$208M
  • Lead/follow: 28% lead, 72% follow
  • Last fund: Likely still investing — raised $470M in 2023

Portfolio highlights

  • Ousia Pharma — Ousia Pharma is paving the way for novel therapeutic strategies using peptide-drug-conjugates
  • Windward Bio — Windward Bio is a clinical-stage, drug development company committed to improving outcomes for people living with serious immunological diseases.
  • Anaconda BioMed — Anaconda Biomed, headquartered in Barcelona, Spain, is among the world's most innovative early stage medical technology companies. The company was founded by Dr. Ofir Arad and Dr. Marc Ribó in 2015, and is developing the ANCD BRAIN™, a novel 3rd Generation Stented Aspiration Thrombectomy System for the treatment of Acute Ischemic Stroke (AIS).
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Mission BioCapital
VC Fund · Cambridge, Massachusetts, United States · 45 investments in United States Biotechnology startups, 9 in the past 12 months

Mission BioCapital is a life science venture capital firm that invests in early-stage companies. The company leadership team has a long history together, investing in and launching dozens of early-stage life science companies. They are located in regions with a rich concentration of research, discovery, and venture capital investment, and they are known by leaders of portfolio companies for the expertise and deep support they provide.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series A, Series B, Venture - Series Unknown
  • Geography: United States, Switzerland, France

Investor stats

  • Total investments: 96
  • Round size: Series A $4.2M–$80M; Series B $21M–$112M; Venture - Series Unknown $2M–$70M
  • Lead/follow: 23% lead, 77% follow
  • Last fund: Likely still investing — raised $275M in 2021

Portfolio highlights

  • Deck Bio — Deck Bio develops T cell engagers that recognize multiple cancer signals, expanding the reach of immunotherapy to treat tumors that other therapies miss.
  • Cloverleaf Bio — Cloverleaf Bio | Developing a new class of RNA therapeutics to revolutionize cancer therapy.
  • Breye Therapeutics — Breye Therapeutics, a Danish-based biopharmaceutical firm in the clinical stages, is working to provide cutting-edge oral treatments for the management of retinal vascular diseases.
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Casdin Capital
VC Fund · New York, New York, United States · 45 investments in United States Biotechnology startups, 8 in the past 12 months

Casdin Capital is a fundamental research investment firm focused on the life sciences and healthcare industry. It manages a long-short equity fund and makes investments in early-stage to late-stage private investments. Casdin was launched in 2012 by founder and CIO Eli Casdin and as of October 2020 has approximately $2.2 billion in assets under management.

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Investment focus

  • Industry: Biotechnology, Health Care, Therapeutics
  • Stage:Series B, Series A, Series C
  • Geography: United States, China, France

Investor stats

  • Total investments: 243
  • Round size: Series A $8.1M–$191M; Series B $32M–$143M; Series C $35M–$175M
  • Lead/follow: 17% lead, 83% follow
  • Last fund: May invest from a new fund soon — raised $30M in 2018

Portfolio highlights

  • Multiply Labs — Multiply Labs develops robotic systems that manufacture small-batch drugs. Current pharma production methods are manual, slow, and costly. We believe that the only way to scale them is with cloud-controlled robots.
  • Flare Therapeutics — Flare Therapeutics is a biotechnology company opening up a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders, Flare’s team has uncovered ‘switch sites,’ druggable regions that are key targets fortranscription factor regulation to address mutations that cause disease. Its drug discovery to target switch sites has rapidly advanced, resulting in an emerging pipeline of drug programs that address well-validated transcription factors, initially focused on precision oncology with future potential in neurology, rare genetic disorders, immunology, and inflammation.
  • Atrium Therapeutics — Atrium Therapeutics is a clinical-stage biotechnology company developing precision RNA medicines for rare genetic cardiomyopathies. It specializes in targeted, non-viral delivery of small interfering RNA (siRNA) directly to heart muscle, building on Avidity Biosciences' Antibody Oligonucleotide Conjugate (AOC) platform to overcome non-specific tissue challenges.
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Dolby Family Ventures
VC Fund · San Francisco, California, United States · 45 investments in United States Biotechnology startups

Investing in early-stage companies solving the biggest science and engineering challenges since 2014.

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Investment focus

  • Industry: Biotechnology, Health Care, Software
  • Stage:Series A, Seed, Series B
  • Geography: United States, Austria, Germany

Investor stats

  • Total investments: 151
  • Round size: Seed $2M–$17M; Series A $6.5M–$50M; Series B $10M–$65M
  • Lead/follow: 9% lead, 91% follow
  • Last fund: May invest from a new fund soon — last raise in 2014

Portfolio highlights

  • Exciva — EXCIVA GmbH is a privately held biotech company focused on development of clinical stage therapeutics for various indications in neuropsychiatry.
  • Molten Salt Solutions — Molten Salt Solutions: Lithium Isotope Enrichment for Advanced Nuclear Power
  • Acta Pharmaceuticals — Acta Pharmaceuticals is a biotechnology company focused on developing new therapies for early intervention and prevention of Alzheimer's disease.
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Keiretsu Forum
VC Fund · San Francisco, California, United States · 44 investments in United States Biotechnology startups

Keiretsu Forum is a global angel investor network with more than 2,500 accredited investor members throughout 47 chapters on 3 continents.

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Investment focus

  • Industry: Health Care, Software, Biotechnology
  • Stage:Venture - Series Unknown, Seed, Series A
  • Geography: United States, India, Turkey

Investor stats

  • Total investments: 566
  • Round size: Seed $125k–$3M; Series A $285k–$8.2M; Venture - Series Unknown $125k–$6.8M
  • Lead/follow: 6% lead, 94% follow
  • Last fund: May invest from a new fund soon — raised $10M in 2015

Portfolio highlights

  • Bliss — Skip long waitlists and expensive therapy. Book licensed online therapists in multiple languages with culturally informed care.
  • BatteryPool — BatteryPool offers battery charging solutions for EV fleets and commercial vehicles.
  • Apriority Financial — In a system built for lenders, Apriority works for borrowers: no hidden lender fees, continuous rate monitoring, and we never sell your data.
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Hatteras Venture Partners
VC Fund · Durham, North Carolina, United States · 43 investments in United States Biotechnology startups, 9 in the past 12 months

Hatteras Venture Partners is a venture capital firm based in Research Triangle Park, NC, with a focus on biopharmaceuticals, medical devices, diagnostics, and related opportunities in human medicine. Founded in 2000, the firm consists of an experienced team with a broad and complementary skill set that is particularly relevant to buildingsuccessful new biomedical companies. The Hatteras Venture Partners team brings operational experience, a successful track record, and a proven ability to enhance the value of the companies in which it invests. With three funds, the firm has more than $120 million under management.

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Investment focus

  • Industry: Health Care, Biotechnology, Medical
  • Stage:Series A, Series B, Series C
  • Geography: United States, Canada

Investor stats

  • Total investments: 142
  • Round size: Series A $2.6M–$50M; Series B $5M–$82M; Series C $8M–$88M
  • Lead/follow: 37% lead, 63% follow
  • Last fund: Likely still investing — raised $30M in 2023

Portfolio highlights

  • RapidPulse — Explore RapidPulse for innovative stroke treatments and technologies. Book appointments or learn about our team and clinical trials.
  • 410 Medical — 410 Medical has developed a simple, intuitive solution that allows a single healthcare provider to rapidly deliver fluid to critically ill patients, improving care, and saving lives. Their device allows fast set-up, improves resuscitation speed, minimizes provider fatigue, and frees providers to address other patient care issues simultaneously.This solution is particularly useful in pre-hospital settings and the emergency department and where speed is critical and resources may be limited.It was founded in 2013 and headquartered in Durham, North Carolina.
  • Ladder Health — Expert speech, occupational, physical, and feeding therapy for children, right from home, with flexible virtual visits and a plan that fits real life.
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Flagship Pioneering
VC Fund · Cambridge, Massachusetts, United States · 43 investments in United States Biotechnology startups

We create breakthroughs in human health and sustainability and build bioplatform companies . Companies founded

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Investment focus

  • Industry: Biotechnology, Health Care, Medical
  • Stage:Series B, Series C, Series A
  • Geography: United States, Canada, United Kingdom

Investor stats

  • Total investments: 257
  • Round size: Series A $6.6M–$75M; Series B $11M–$230M; Series C $12M–$123M
  • Lead/follow: 47% lead, 53% follow
  • Last fund: Likely still investing — raised $2.6B in 2024

Portfolio highlights

  • ZoomInfo — ZoomInfo is the #1 GTM Platform: Marketing and sales AI plus the best B2B data. All-in-one lead generation, prospecting, market intelligence , and ABM software.
  • iris labs — Iris Labs is an AI company focused on improving human wellbeing through personalized AI experiences for self-awareness, and personal growth.
  • Serif Bio­med­i­cines — Serif Biomedicines is pioneering Modified DNA as a new type of biotechnology. Serif combines nucleic acid chemistry, synthetic biology, delivery technology, and artificial intelligence to develop programmable, scalable, long-lasting, and redosable DNA therapies.
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Refactor
VC Fund · Burlingame, California, United States · 43 investments in United States Biotechnology startups

Refactor is a seed-stage hard tech venture firm. Solo GP Zal Bilimoria writes $1-2M checks into founders building in aerospace, energy, bio, health, nuclear, defense, advanced manufacturing, and critical materials. Better Call Zal.

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Investment focus

  • Industry: Health Care, Biotechnology, Medical
  • Stage:Seed, Series A, Series B
  • Geography: United States, United Kingdom, New Zealand

Investor stats

  • Total investments: 120
  • Round size: Seed $2.7M–$11M; Series A $8M–$34M; Series B $16M–$103M
  • Lead/follow: 18% lead, 82% follow
  • Last fund: Likely actively investing — fresh fund, raised $50M in 2026

Portfolio highlights

  • Pilgrim — Pioneering a biologically enhanced future for humanity.
  • Onyx Bio — Onyx traces multiomic patient trajectories across immune health, aging, and disease, built for precision medicine.
  • The Biological Computing — Biological Black Box integrates biological neurons with artificial neural networks to develop a living computer.
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Lightspeed Venture Partners
VC Fund · Menlo Park, California, United States · 43 investments in United States Biotechnology startups

Lightspeed Venture Partners is a multi-stage venture capital firm focused on accelerating disruptive innovations and trends.

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Investment focus

  • Industry: Software, Artificial Intelligence, Information Technology
  • Stage:Series A, Seed, Series B
  • Geography: United States, India, Israel

Investor stats

  • Total investments: 2448
  • Round size: Seed $2M–$26M; Series A $7M–$85M; Series B $15M–$125M
  • Lead/follow: 40% lead, 60% follow
  • Last fund: Likely actively investing — fresh fund, raised $600M in 2025

Portfolio highlights

  • Tennr — Tennr is a custom AI assistant that accelerates research, answers complex questions, and generates custom reports.
  • Whizzo — Whizzo specializes in materials science-driven manufacturing of engineered fashion and technical textiles. Our expertise lies in creating and executing innovative textile blends tailored for applications across automotive, agriculture, medical textiles, and engineered fashion.
  • Zaria Systems — Zaria provides loan servicing and collateral management infrastructure for banks, private credit firms, fintech lenders, and digital asset lenders. Its platform supports primary servicing and auditable collateral management for structured finance and digital asset-backed lending. The company combines these functions within a single platform for institutional lending operations.
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Life Science Angels
VC Fund · Sunnyvale, California, United States · 42 investments in United States Biotechnology startups

Life Science Angels, Inc. (LSA) is the premier angel investment group focused solely on healthcare investing, including medical devices, diagnostics, pharmaceuticals, biotechnology, and digital health.

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Investment focus

  • Industry: Biotechnology, Health Care, Medical
  • Stage:Seed, Series A
  • Geography: United States, Israel, The Netherlands

Investor stats

  • Total investments: 95
  • Round size: Seed $1M–$4M; Series A $1.3M–$10M
  • Lead/follow: 8% lead, 92% follow

Portfolio highlights

  • ATDev — ATDev builds robotic mobility and assistive technology for older adults and people with disabilities
  • Journey Live — Journey is shifting the way modern companies prioritize mental health. Our proactive, inclusive tools engage every employee, every day.
  • Trio Pharmaceuticals — Trio Pharmaceuticals is a cancer therapeutics company that develops dual-action drugs for immunogenic tumors. These drugs directly stop tumor growth and selectively stop immunosuppression in the tumor without targeting the current immune checkpoint pathways. The company was founded in 2018 and is headquartered in San Diego, California.
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Keiretsu Capital
VC Fund · Seattle, Washington, United States · 42 investments in United States Biotechnology startups

Keiretsu Capital LLC is an affiliate of the World's Leading Angel Network, Keiretsu Forum, and manages funds which enable limited partners to co-invest in the proprietary deal flow of the angel investors.

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Investment focus

  • Industry: Health Care, Biotechnology, Software
  • Stage:Series A, Convertible Note, Seed
  • Geography: United States, Canada, India

Investor stats

  • Total investments: 287
  • Round size: Seed $400k–$2.5M; Series A $811k–$12M; Convertible Note $50k–$3M
  • Lead/follow: 1% lead, 99% follow
  • Last fund: Likely still investing — raised $3.7M in 2022

Portfolio highlights

  • MiClient — Miclient are deal closure platform which was founded by experienced sales leaders who recognized the need for a new generation of complicated quote configuration, contract signing, renewal & payment collection at one place for SMEs, Lead Management System, B2B SaaS, CRM software, CPQ (Configure- Price- Quote)
  • Healionics — Healionics aims to provide safer, more reliable means of bloodstream access for dialysis in patients with kidney failure.
  • NuvOx Therapeutics — NuvOx Pharma is a clinical stage biotech company developing an innovative platform of oxygen therapeutics to treat life-threatening diseases where hypoxia plays a role.
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Novo Holdings
VC Fund · Hellerup, Hovedstaden, Denmark · 42 investments in United States Biotechnology startups

Novo Holdings is a world-leading life science investor with a focus on creating long-term value.

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Investment focus

  • Industry: Biotechnology, Health Care, Medical
  • Stage:Series A, Series B, Series C
  • Geography: United States, Denmark, United Kingdom

Investor stats

  • Total investments: 409
  • Round size: Series A $9.5M–$133M; Series B $15M–$135M; Series C $30M–$118M
  • Lead/follow: 40% lead, 60% follow
  • Last fund: May invest from a new fund soon — raised $165M in 2018

Portfolio highlights

  • IVERIC bio — IVERIC bio is a science-driven biopharmaceutical company focused on the discovery and development of novel treatment options for retinal diseases with significant unmet medical needs. The Company is currently developing both therapeutic product candidates for age-related retinal diseases and gene therapy product candidates for orphan inheritedretinal diseases.
  • Windward Bio — Windward Bio is a clinical-stage, drug development company committed to improving outcomes for people living with serious immunological diseases.
  • SCHOTT Poonawalla — SCHOTT Poonawalla is a manufacturer of pharmaceutical containers, made of neutral glass tubing. The company provides parenteral packaging systems crafted from tubular glass, serving the pharmaceutical industry with a broad range of products including vials, pre-fillable syringes, ampoules, and cartridges.
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General Catalyst
VC Fund · Cambridge, Massachusetts, United States · 41 investments in United States Biotechnology startups

Investing in powerful, positive change that endures

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Investment focus

  • Industry: Software, Artificial Intelligence, Health Care
  • Stage:Seed, Series A, Series B
  • Geography: United States, India, United Kingdom

Investor stats

  • Total investments: 2303
  • Round size: Seed $1.6M–$18M; Series A $6.7M–$75M; Series B $14M–$123M
  • Lead/follow: 46% lead, 54% follow
  • Last fund: Likely actively investing — fund raised in 2026

Portfolio highlights

  • Lemonade — Lemonade operates as a full-stack insurance company powered by AI and behavioral economics and driven by social good. It is a licensed insurance carrier, offering homeowners and renters insurance. Lemonade replaces brokers and bureaucracy with bots and machine learning, delivering zero paperwork and instant everything. The company uses artificialintelligence and behavioral economics to set rates for the homes and renters it insures. Lemonade was founded in Tel Aviv, Israel, in 2015 and is headquartered in New York, NY, United States.
  • Datalogix — Datalogix® is the industry-recognized leader at connecting digital media and offline purchasing data. We help more than half of the top 100 consumer marketers increase the effectiveness and measurability of their advertising. DLX Platform®, encompasses over $1 trillion in consumer spending and powers campaigns for more than 75% of online mediacompanies. DLX ROI® is rapidly becoming the industry standard for measuring offline sales lift for digital media. Datalogix also offers predictive analytics for Direct Mail, and integrated media solutions via the DLX Net. Our expertise spans the major consumer segments, including Retail, CPG, Automotive, Telecom, Travel and Financial Services. We are based in Colorado, with offices in New York City, San Francisco, Boston, Chicago, Detroit, and London.
  • Ayr Energy — Ayr Energy designs, engineers, manufactures, and supplies power transformers, distribution transformers, switchgear, and circuit breakers.
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Biotechnology VC funding in United States at a glance

Stats across 20k deals from 9.4k investors.

9.4k
investors
in United States Biotechnology startups
20k
deals
in United States Biotechnology startups
$9.5M
median round
in United States Biotechnology startups
44%
lead investors
lead at least one round
18%
Grant
most common funding stage

Access all 9357 VC funds in United States Biotechnology startups.

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