Top 10 CleanTech VC (Venture Capital) Funds in Italy in April 2025

Last updated: Apr 2025 A list of 10 VC (Venture Capital) funds that invest in Cleantech startups based in Italy. We rank investors based on the number of investments they made in Cleantech companies from Italy. We update this investor list every month.

Top 10 CleanTech VC (Venture Capital) Funds in Italy in April 2025

Investor	CleanTech Italy investments
Cassa Depositi e Prestiti	6
CDP Venture Capital	4
Eureka Venture	1
Club degli Investitori	1
LIFTT	1
Novum Capital Partners	1
Lazio Innova	1
Key Capital	1
A11 Venture	1
NextEnergy Capital	1

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Investor list

The Cassa Depositi e Prestiti Group is the national promotional institution that has supported the Italian economy since 1850

Investment focus

Health Care, Manufacturing, CleanTech
Pre-Seed, Post-IPO Debt, Debt Financing
Italy, Spain

Portfolio highlights

Arxax — Arxax is a cleantech company paving the way towards a more sustainable future by revolutionizing refueling in road transport.Through our passion for a cleaner, greener world we have developed a smart network of green refueling stations powered by our proprietary suite of connected technology solutions. Our suite of products uses data signalsfrom existing IoT hardware devices such as truck telematics, sensors, Outdoor Payment Terminals and smartphones to bring access to low and zero carbon fuels at optimally located refuelling stations, competitive pricing and full refuelling visibility to our customers.
MrCall — Un assistente digitale dedicato al tuo business, che risponde quando non puoi, raccoglie i messaggi e li trascrive in una mail, un SMS o un messaggio Whatsapp.Configurabile e attivo sul telefono in due passaggi. Senza cambiare operatore, senza installare nuovi software, senza nuovi centralini.Nessun investimento o costo di attivazionerichiesto.
TimeFlow — TimeFlow is a software that acts as a B2B marketplace dedicated to the technical and managerial consulting sector.

CDP Venture Capital Sgr - National Innovation Fund aims to make venture capital a cornerstone of the country's economic development and innovation, creating the conditions for an overall and sustainable growth of the venture capital ecosystem.

Investment focus

Software, Information Technology, Health Care
Seed, Series A, Funding Round
Italy, United States, Germany

Portfolio highlights

Mopso — Discover Mopso's anti money laundering detection system. Visit our website and try a 30 minutes free demo with one of our experts.
Postura Ergonomics — Postura transform workers videos into ergonomic risk assessments for manufacturing companies. Our AI delivers quick, accurate, and scalable analyses, cutting costs and compliance time. ergonomia lavoro ufficio
Genoa Instruments — Genoa Instruments is an innovative startup dedicated to transforming the field of biomedical and health research through advanced super-resolution optical microscopy. Our groundbreaking optical microscope uniquely integrates spatial and temporal super-resolution for structural and functional imaging in living samples with unprecedented detail. Ourmission is to make high-resolution imaging accessible to all, fostering scientific discovery and advancing healthcare research.

Eureka! is the first independent Italian venture capital Asset Management company exclusively focused on deep tech investments

Investment focus

Nanotechnology, Renewable Energy, Medical Device
Funding Round, Seed, Pre-Seed
Italy

Portfolio highlights

Planckian — Charging the future by powering energy with science We explore frontiers of energy science by developing quantum...
INTA Systems — Nanotech and artificial intelligence for biomolecular analysis
BeDimensional — New Material Solution

Club degli Investitori (Investors Club) is a network of investors and business angels that invest on early-stage SMEs and startups. The community of 300+ Members (entrepreneurs, CEOs, executive managers) actively scouts for investing opportunities on SMEs & startups and invests with a minimum ticket of €200k. The Club supports business byinvesting capital and by leveraging the Members' network and experience.Club degli Investitori is supported by Unicredit and KPMG Italy.

Investment focus

Health Care, E-Commerce, Information Technology
Seed, Series A, Series B
Italy, Switzerland, United Kingdom

Portfolio highlights

Stema — It serves as a platform for hiring engineers
Approxima — Approxima medical is developing a novel treatment for patients with tricuspid valve regurgitation
Lymphatica Medtech — Lymphatica Medtech is a medical device development company developing a minimally invasive solution for chronic lymphedema.Lymphedema is the chronic swelling that generally occurs in the arms or the legs.Lymphedema is most commonly caused by the removal of or the damage to the lymph nodes as a part of cancer treatment. It results from ablockage in the lymphatic system, which is part of the immune system. The blockage prevents the lymphatic system from draining excess fluids, and the fluid buildup leads to swelling, infections, and pain.Unfortunately, there is no cure for lymphedema. It can be managed with early diagnosis and diligent care of the affected limb, through daily compression, bandages, and manual drainage sessions. From the moment of the diagnosis, the life of lymphedema patients changes forever.Cancer and cancer-related interventions (i.e. surgery, radiotherapy) are frequent causes of lymphedema occurring both in the upper and lower limbs. Breast cancer survivors are at high risk for developing lymphedema, as well as patients treated for melanoma, pelvic and head and neck cancer or other cancer treatments that require lymph node dissection. Physical trauma can also result in lymphedema, a major cause of lymphatic disease among wounded veterans.Lymphedema is associated with significantly impaired quality of life, skin changes, increased risk of infection and in rare cases lymphedema itself may undergo malignant transformation.Lymphatica offers a permanent solution that will allow patients to regain their normal lifestyle.

A not-only-profit operating investment company, eager to create a bridge between innovative ideas, territory and capital.

Investment focus

Biotechnology, Software, Information Technology
Seed, Funding Round, Series A
Italy, United Kingdom, France

Portfolio highlights

Mediaire — mediaire supports radiologists with AI-based tools for MRI reporting. This enables them to make a more accurate and objective assessment even faster.
MicroLub — MicroLub produces a fat replacement for lower-calorie plant-based diets. It is cutting-edge innovation to the next generation of protein technology, creating exclusive ingredient solutions that significantly minimize molecular friction.
Composite Research — CoRe Research is an start-up, aimed at the study of new product and process solutions in the field of composite materials.

Novum Capital Partners is a Swiss multi-family office.

Investment focus

Energy, CleanTech, Smart Cities
Seed, Series B
Italy

Portfolio highlights

Wiseair — Wiseair's mission is to enable everyone in the world to breathe clean air. We believe that a problem you can't measure is a problem you can't solve, so we work to enable municipalities, citizens and businesses to measure and learn about air quality, creating actionable, solution-oriented data and information, and generatingawareness.
Energy Dome — Energy Dome | Groundbreaking Long Duration Energy Storage. Using CO2 against climate change. Our Technology enables to store renewable energy efficiently.

Lazio Innova is a venture capital firm with its headquarters in Rome in Italy. The firm provides services in areas such as credit support and guarantees, interventions in risk capital, internationalization services, promotion of business networks and services for the creation and enterprise development.

Investment focus

Software, Health Care, Artificial Intelligence
Seed, Pre-Seed, Grant
Italy, United Kingdom

Portfolio highlights

Joinrs — We developed an artificial intelligence model able to read job offers for you and show you the ones that best match your profile.
Medicud — Medicud develops a device for treating wounds with negative pressure dressing.
Ticketoo — Ticketoo: compra e vendi biglietti fan-to-fan in modo sicuro

We are a venture incubator that wants to exploit the extraordinary human capital of the new digital entrepreneurship. From design to ready-to-market, up looking for new partners and capital, we create value along the entire continuum of mentoring: direct investment , skills qualified and specialized network support the growth of new businesses oftomorrow. With our deal flow , we are able to select innovative ideas with high potential with a business model that minimizes the investment risk and guarantee the success on the market.

Investment focus

Internet, Apps, E-Commerce
Seed, Pre-Seed, Series A
Italy, United States, Philippines

Portfolio highlights

Pixies — Pixies is a Startup that design solutions for Autonomous Cities and a more sustainable future of our planet. Merging Urban Design, Robotics and AI, we believe that urban spaces can now become able to take care of themselves.
Alokino Gelato — Alokino Gelato produces plant-based and preservative-less artisanal ice creams.
Wopta Assicurazioni — Wopta Assicurazioni is the first Italian phygital insurtech which, thanks to a digital platform and a network of tied specialist throughout the country, was created to protect artisans, SMEs and freelances from everyday risks.

A11-Venture investe nel capitale di startup innovative nei settori della robotica, automazione, meccatronica, cleantech, web e IT. Facilita la nascita e lo sviluppo di business innovativi globali per il futuro dell'economia locale. Contribuisce a costruire aziende, lavoro qualificato, brevetti, innovazione capaci di rilanciare e riportareinvestimenti e risorse sul territorio. I soci di A11 Venture credono fermamente nell’innovazione grazie a ciò è possibile crescere per linee esterne diversificando i propri investimenti, grazie ad un portafoglio di imprese, con una forte risk mitigation derivante dalla gestione professionale di tutti processi: scouting, team building, investimenti, management degli investimenti, accelerazione e disinvestimento.

Investment focus

Biotechnology, Medical Device, Health Care
Seed, Pre-Seed, Series A
Italy, United States

Portfolio highlights

Reefilla — Reefilla EV charging services: recharge your car anywhere, anytime
Endostart — Endostart development and manufacturing of a new generation medical devices for gastrointestinal endoscopy.
Neuron Guard — Neuron Guard, recognized as the best European startup in HEALTH category (Startup Europe Awards - SEUA 2017), is developing a life-saving medical device that aims to become the standard of care for Targeted Temperature Management (TTM) therapy. Every 7 seconds around the world a person suffers of Acute Brain Damage because of CardiovascularDiseases (CVD) and Traumatic Brain Injury (TBI). They are the most costly and prevalent killers in the last 15 years (15 million deaths by CVD in 2015), and the leading cause of disability (the global incidence rate of TBI is 200 per 100k people per year). WHO estimated a global expenditure of $ 330 billion in 2015, but it is going to increase sharply: $ 4 trillion in 2025 - including premature death, disability, and health care costs - just for CVD in LMICs. Temperature is a vital body parameter. It regulates all cellular functions so its management is essential for the good outcome of patients in several medical conditions such as cardiac arrest, stroke, traumatic brain injury, neuro and cardiac surgery, epilepsy, migraine and oncology. Regulating body temperature at a desired level makes all other treatments more effective. The most modern medical approach is the target temperature management, where physicians try to maintain the most favourable temperature for the patient for up to 24-36 hours, preventing excessive warming (fever) or cooling.Our device is a targeted temperature management system composed by a THERAPEUTIC COLLAR POWERED BY A SMART CONTROL UNIT (the size of a small briefcase). The collar transforms the neck into a natural heat exchanger exploiting several physiological and anatomical characteristics of the human body. It is quicker to act on brain tissue but can also function as total body temperature adjusting device if required. A disposable protective shield makes cleaning the collar after each use simple while featuring an optimal safety profile both in term of pathogens and allergens. The control unit collects all the data of the treatment and transmits them to the Emergency Response System. Our mission is to improve the safety of patients on the roadside, at home or in the workplace, and to reduce the costs of chronic care. In fact, Neuron Guard aims to be the only device that can be used in every circumstance, inside and outside the hospital, and allow the user to fully manage the temperature of the patient warming and cooling as necessary. Our vision is to have a Neuron Guard kit in every public place just like the Automatic External Defibrillator (AED) to empower bystanders to immediately react in case of emergency. Under this perspective our device becomes a connected-intelligent platform that takes care of the patient, connects the scene with the Emergency Response System transmitting vital data to improve the readiness and effectiveness of professional intervention.The device is patented in Italy, USA and China. We have made several prototypes in collaboration with Italian and English companies, such as Tecno Elettra Impianti and TWI, tested it in laboratory and published the experimental results on the NeuroCritical Care Journal. We have also conducted a GAP Analysis with another English consulting firm (CDP) and we are testing the human prototype internally. We are seeking to raise 2.5M€ to complete the pre-industrialization, with design and construction of the human device for the pilot trial, finalized the regulatory clearance and launch it into the market in 2019.

NextEnergy Capital is an investment management business founded in 2007, Their head office are in London, United Kingdom. NextEnergy Capital focus on the renewable energy sector with a presence in Italy and South Africa. NextEnergy Capital believes in the sustainable energy investment opportunity and plans to selectively add on other businesses.