Top 10 CleanTech VC (Venture Capital) Funds in Italy in September 2025

Last updated: Sep 2025 A list of 10 VC (Venture Capital) funds that invest in Cleantech startups based in Italy. We rank investors based on the number of investments they made in Cleantech companies from Italy. We update this investor list every month.

Top 10 CleanTech VC (Venture Capital) Funds in Italy in September 2025

Investor	CleanTech Italy investments
Cassa Depositi e Prestiti	6
CDP Venture Capital	5
NextEnergy Capital	1
Novum Capital Partners	1
Key Capital	1
A11 Venture	1
Club degli Investitori	1
EUREKA! Venture SGR	1
Lazio Innova	1
LIFTT	1

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Investor list

The Cassa Depositi e Prestiti Group is the national promotional institution that has supported the Italian economy since 1850

Investment focus

Health Care, Manufacturing, CleanTech
Pre-Seed, Post-IPO Debt, Debt Financing
Italy, Spain

Portfolio highlights

BKN301 — Scopri tutti i servizi dedicati a privati, aziende ed esercenti. Accedi all'area riservata.
NextChem — NextChem is the green chemistry subsidiary of Maire Tecnimont, an Italian multinational company specializing in engineering, technology, and energy. NextChem focuses on the energy transition by developing and deploying innovative solutions for sustainable industrial processes. It aims to accelerate decarbonization and promote the circular economythrough advanced technologies.
TimeFlow — TimeFlow is a software that acts as a B2B marketplace dedicated to the technical and managerial consulting sector.

CDP Venture Capital Sgr - National Innovation Fund aims to make venture capital a cornerstone of the country's economic development and innovation, creating the conditions for an overall and sustainable growth of the venture capital ecosystem.

Investment focus

Software, Information Technology, Health Care
Seed, Series A, Funding Round
Italy, United States, United Kingdom

Portfolio highlights

Soplaya — Soplaya is a B2B food company connecting chefs and farmers to build a diverse, sustainable, and efficient food system.By providing data and transparency to an opaque supply chain, we help chefs to simplify purchases, get a wider selection of products and save money and farmers to increase their margins and get easy access to the market.We lovequality food as much as technology and automation. We are rebels: we love transparency and how the internet is capable of bringing the long tail to the market. We're excited about the fact that the restaurant supply chain hasn't basically changed since 40 years, and was technology reluctant for a long time, but restaurants necessities changed dramatically in the last 3 years.We’re becoming the standard layer for restaurant purchasing across Europe, by bringing transparency and simplicity in the procurement phase, increasing order frequency, promoting lean inventory and food waste reduction.
lit — Con lit puoi monitorare, quando e dove vuoi, i tuoi consumi energetici, riducendoli fino al 22%, avendo informazioni in real time sui tuoi elettrodomestici.
Tulum Energy — Discover how Tulum Energy harnesses methane pyrolysis technology to transform machinery and produce substantial volumes of clean hydrogen, driving innovation and sustainability in the energy sector.

NextEnergy Capital is an investment management business founded in 2007, Their head office are in London, United Kingdom. NextEnergy Capital focus on the renewable energy sector with a presence in Italy and South Africa. NextEnergy Capital believes in the sustainable energy investment opportunity and plans to selectively add on other businesses.

Investment focus

CleanTech, GreenTech, Recycling
Pre-Seed
Italy

Portfolio highlights

BUFAGA — Aiutiamo le aziende a diventare realmente sostenibili attraverso dispositivi smart in grado di rimuovere l'inquinamento e di raccogliere ed analizzare dati.

Novum Capital Partners is a Swiss multi-family office.

Investment focus

Energy, CleanTech, Smart Cities
Seed, Series B
Italy

Portfolio highlights

Wiseair — Wiseair's mission is to enable everyone in the world to breathe clean air. We believe that a problem you can't measure is a problem you can't solve, so we work to enable municipalities, citizens and businesses to measure and learn about air quality, creating actionable, solution-oriented data and information, and generatingawareness.
Energy Dome — Energy Dome | Groundbreaking Long Duration Energy Storage. Using CO2 against climate change. Our Technology enables to store renewable energy efficiently.

We are a venture incubator that wants to exploit the extraordinary human capital of the new digital entrepreneurship. From design to ready-to-market, up looking for new partners and capital, we create value along the entire continuum of mentoring: direct investment , skills qualified and specialized network support the growth of new businesses oftomorrow. With our deal flow , we are able to select innovative ideas with high potential with a business model that minimizes the investment risk and guarantee the success on the market.

Investment focus

Internet, Apps, E-Commerce
Seed, Pre-Seed, Series A
Italy, United States, Philippines

Portfolio highlights

Pixies — Pixies is a Startup that design solutions for Autonomous Cities and a more sustainable future of our planet. Merging Urban Design, Robotics and AI, we believe that urban spaces can now become able to take care of themselves.
Alokino Gelato — Nikmati permainan slot gacor hari ini di situs gacor kangtoto, hanya dengan deposit 1000, 5000 ataupun depo 5k sudah bisa merasakan maxwin tak terbatas di slot online dengan deposit via dana tanpa potongan sedikitpun.
Wopta Assicurazioni — Wopta Assicurazioni is the first Italian phygital insurtech which, thanks to a digital platform and a network of tied specialist throughout the country, was created to protect artisans, SMEs and freelances from everyday risks.

A11-Venture investe nel capitale di startup innovative nei settori della robotica, automazione, meccatronica, cleantech, web e IT. Facilita la nascita e lo sviluppo di business innovativi globali per il futuro dell'economia locale. Contribuisce a costruire aziende, lavoro qualificato, brevetti, innovazione capaci di rilanciare e riportareinvestimenti e risorse sul territorio. I soci di A11 Venture credono fermamente nell’innovazione grazie a ciò è possibile crescere per linee esterne diversificando i propri investimenti, grazie ad un portafoglio di imprese, con una forte risk mitigation derivante dalla gestione professionale di tutti processi: scouting, team building, investimenti, management degli investimenti, accelerazione e disinvestimento.

Investment focus

Biotechnology, Medical Device, Health Care
Seed, Pre-Seed, Series A
Italy, United States

Portfolio highlights

Reefilla — Reefilla EV charging services: recharge your car anywhere, anytime
Endostart — Endostart development and manufacturing of a new generation medical devices for gastrointestinal endoscopy.
Neuron Guard — Neuron Guard, recognized as the best European startup in HEALTH category (Startup Europe Awards - SEUA 2017), is developing a life-saving medical device that aims to become the standard of care for Targeted Temperature Management (TTM) therapy. Every 7 seconds around the world a person suffers of Acute Brain Damage because of CardiovascularDiseases (CVD) and Traumatic Brain Injury (TBI). They are the most costly and prevalent killers in the last 15 years (15 million deaths by CVD in 2015), and the leading cause of disability (the global incidence rate of TBI is 200 per 100k people per year). WHO estimated a global expenditure of $ 330 billion in 2015, but it is going to increase sharply: $ 4 trillion in 2025 - including premature death, disability, and health care costs - just for CVD in LMICs. Temperature is a vital body parameter. It regulates all cellular functions so its management is essential for the good outcome of patients in several medical conditions such as cardiac arrest, stroke, traumatic brain injury, neuro and cardiac surgery, epilepsy, migraine and oncology. Regulating body temperature at a desired level makes all other treatments more effective. The most modern medical approach is the target temperature management, where physicians try to maintain the most favourable temperature for the patient for up to 24-36 hours, preventing excessive warming (fever) or cooling.Our device is a targeted temperature management system composed by a THERAPEUTIC COLLAR POWERED BY A SMART CONTROL UNIT (the size of a small briefcase). The collar transforms the neck into a natural heat exchanger exploiting several physiological and anatomical characteristics of the human body. It is quicker to act on brain tissue but can also function as total body temperature adjusting device if required. A disposable protective shield makes cleaning the collar after each use simple while featuring an optimal safety profile both in term of pathogens and allergens. The control unit collects all the data of the treatment and transmits them to the Emergency Response System. Our mission is to improve the safety of patients on the roadside, at home or in the workplace, and to reduce the costs of chronic care. In fact, Neuron Guard aims to be the only device that can be used in every circumstance, inside and outside the hospital, and allow the user to fully manage the temperature of the patient warming and cooling as necessary. Our vision is to have a Neuron Guard kit in every public place just like the Automatic External Defibrillator (AED) to empower bystanders to immediately react in case of emergency. Under this perspective our device becomes a connected-intelligent platform that takes care of the patient, connects the scene with the Emergency Response System transmitting vital data to improve the readiness and effectiveness of professional intervention.The device is patented in Italy, USA and China. We have made several prototypes in collaboration with Italian and English companies, such as Tecno Elettra Impianti and TWI, tested it in laboratory and published the experimental results on the NeuroCritical Care Journal. We have also conducted a GAP Analysis with another English consulting firm (CDP) and we are testing the human prototype internally. We are seeking to raise 2.5M€ to complete the pre-industrialization, with design and construction of the human device for the pilot trial, finalized the regulatory clearance and launch it into the market in 2019.

Club degli Investitori (Investors Club) is a network of investors and business angels that invest on early-stage SMEs and startups. The community of 300+ Members (entrepreneurs, CEOs, executive managers) actively scouts for investing opportunities on SMEs & startups and invests with a minimum ticket of €200k. The Club supports business byinvesting capital and by leveraging the Members' network and experience.Club degli Investitori is supported by Unicredit and KPMG Italy.

Investment focus

Health Care, E-Commerce, Information Technology
Seed, Series A, Series B
Italy, Switzerland, United Kingdom

Portfolio highlights

Stema — It serves as a platform for hiring engineers
Approxima — Approxima medical is developing a novel treatment for patients with tricuspid valve regurgitation
Annaida Technologies — Annaida Technologies has developed a groundbreaking device, EmbryoSpin, that performs microscopic Nuclear Magnetic Resonance (“µNMR”) at a scale 10-fold better than existing technologies.

Eureka! is the first independent Italian venture capital Asset Management company exclusively focused on deep tech investments

Investment focus

Nanotechnology, Renewable Energy, Medical Device
Seed, Funding Round, Pre-Seed
Italy

Portfolio highlights

Novac — Progettiamo supercondensatori da affiancare alle batterie, per incrementare performance ed efficienza dei veicoli elettrici.
WISE — WISE (Wiringless Implantable Stretchable Electronics) is a start-up company created in 2011 with the mission of producing the new generation of leads for neuromodulation for treatment of chronic pain and Parkinson: unbreakable, less invasive and cheaper.
BeDimensional — New Material Solution

Lazio Innova is a venture capital firm with its headquarters in Rome in Italy. The firm provides services in areas such as credit support and guarantees, interventions in risk capital, internationalization services, promotion of business networks and services for the creation and enterprise development.