Top 40 Enterprise Startup Investors in Puerto Rico (September 2026)

Portfolio highlights

• Luminoah — Discover Luminoah Flow, the world's smallest enteral nutrition delivery system designed for your active lifestyle. Empower your nutrition journey today.
• Cloverleaf AI — Cloverleaf AI turns 1.5 million government meetings into early buying signals, so you reach buyers before the RFP. Government sales intelligence for B2G sellers.
• Apira Technologies — Apira Technologies provides a persona platform that enables users to pilot photorealistic avatars and scenes over desktop video conference systems and streaming platforms.

Portfolio highlights

• Wirelane — Driven by the mission "We empower people to move towards a clean future", Wirelane has been designing sustainable mobility since 2016 and is developing innovative complete solutions for the construction, operation, and marketing of charging infrastructure. Wirelane provides its customers with all the necessary service modules, rangingfrom cutting-edge charging technology to a digital management and billing platform, as well as comprehensive installation and operation services.
• Flashcookie — Flashcookie is an on-demand merchandise for independent artists based in Buenos Aires, Argentina.
• Solve Therapeutics — Solve Therapeutics is a biopharmaceutical company that develops Antibody Drug Conjugate and Bispecific Therapeutics. The company was founded in 2021 and is headquartered in Belmont, California.

Portfolio highlights

• Toteat — Headquarters located at Vitacura 2771, of. 504, Las Condes, Santiago de Chile
• Kiwi — Kiwi is a leading platform that helps Latinos living in the US, who may have limited credit data and access to capital, build credit history through unsecured lines of credit and alternative credit builder programs. As the fastest-growing minority segment in the US, the Latino market is expected to reach over 100 million in the next few decades.Our mission is to empower Latinos by providing tools and resources to establish credit, access capital and save money.
• BackChannel — BackChannel is an online B2B platform for inventory transactions and for buying and selling online goods.

Portfolio highlights

• Kashable — Kashable is on a mission to help employees handle unexpected expenses and tackle high-interest debt. Our platform provides financial wellness solutions that help employees to preserve retirement savings, improve their credit scores, and navigate financial hardships responsibly. Plus, Kashable provides employees access to free Financial Literacy resources to help plan for the future.
• Aura Financial — Aura is a technology-powered, Community Development Financial Institution that provides fair, affordable loans to working families in America. Aura's mission is to build financially healthy low-income communities, by providing empowering financial services to underbanked and unbanked.Aura uses its proprietary scoring algorithms to review andapprove credit applications and offers free credit scores and personalized expense management guidance to borrowers, allowing the working population to access loans in a simplified manner.Aura was founded in 2014 and is headquartered in San Francisco, California, USA.
• Revolution Money — Revolution Money is a financial services company with the goal of disrupting incumbent credit companies and PayPal. Revolution Money's credit card, the RevolutionCard, differs from other credit cards by using PIN-activation, rather than signatures This allows the card to be printed without any personally identifying information, which thecompany claims helps to reduce identity theft. The card transactions are also processed on an internet-based system, allowing the company to drastically reduce its processing fees. Revolution Money's other main service is MoneyExchange, which pretty much does what one would think -- let users transfer money between one another -- but, uniquely, a MoneyExchange account holders can use a Revolution Money Debit/ATM card so money can be accessed at stores or withdrawn from ATMs. Transfers between Revolution Money account holders are free.Revolution Money is partially owned by Revolution, LLC, an investment firm and holding company owned by AOL-founder Steve Case. The company's board also boasts an impressive number of financial luminaries, including Lawrence Summers, former US Secretary of the Treasury; Franklin Raines, former CEO of Fannie Mae; Russell Hogg, former President and CEO of MasterCard; David Pottruck, former CEO of Charles Schwab; and David Golden, former Vice Chairman of JPMorgan.

Portfolio highlights

• Qredo — Qredo is a cross-chain protocol for asset managers and traders active in the digital asset markets. Using our institution-grade, layer 2 infrastructure, investors can now hold all their crypto assets securely in one place, with unlocked access to a wide range of liquidity venues and DeFi yield opportunities.
• AuDIGENT — AuDIGENT is an audience intelligence platform that provides brands with actionable data, analytics and insights that optimize the targeting, engagement and ROI of online, mobile and social video ads while opening up new revenue streams for artists and other social influencers. AuDIGENT's platform allows brands to discover, monitor and targetaudiences that drive media performance. AuDIGENT's platform empowers artists and influencers to tap into the tools and technology needed to monetize their social influence and fan engagement. AuDIGENT's executives, data scientists, developers and operations team are in New York, Philadelphia and London. For more information visit AuDIGENT.com
• Tea — Learn more about the tea protocol and how to unlock the rewards for previous and future open-source software contributions.

Portfolio highlights

• CASIMIR —
• illumicell AI — illumicell AI combines patented AI algorithms and proprietary microscopy technology to test 50x faster, 20x more effectively, empowering every healthcare provider at the point of care – not just fertility clinics – with accessible, scalable fertility diagnostics.
• SignalRank — SignalRank Corporation is a FinTech company in the Venture space. It focuses on the seed stage asset class and uses data analytics to allocate capital to the best seed fund managers for their top performing companies. GPRank and CompanyRank are two proprietary algorithms it leverages to automate capital allocation. The company invests from balancesheet. Its customers are seed stage investors with outstanding companies in their portfolio.

Portfolio highlights

• GooseFX — GooseFX is your premier destination for everything
• Neftify — Neftify is a blockchain powered platform for crowd sourcing game assets and loaning them to players.
• Banksea Finance — Banksea Finance is an AI-powered NFT Oracle and NFT Pool-based Lending platform.

Portfolio highlights

• XRADERS — Powering informed decision making for investors XRADERS
• Root Protocol — ISME is building an operating system with the composition of an intent-centric aggregator of digital identity, virtual accounts, social graphs, and more to enable unified access to Web3.
• TON Strategy Company — VERB Technology Company is a software-as-a-Service, or SaaS, applications platform developer. Its platform is comprised of sales enablement business software products marketed on a subscription basis. The applications are available in both mobile and desktop versions. It includes verbCRM, Customer Relationship Management application, verbLEARN,Learning Management System application, and verbLIVE, its Live Broadcast Video Webinar application.

Portfolio highlights

• 3DOS — 3DOS operates as a peer-to-peer manufacturing network. It allows brands, influencers, artists, or inventors to take a design to product in hours, by protecting royalties and allowing those products to be made on demand globally via a 3d manufacturing network.
• InstaSecure — InstaSecure develops a security platform designed to protect cloud assets. It allows users to quickly build a data perimeter to prevent attacks from misconfigurations, compromised credentials, and
 future unknown threats.
• FaradaIC Sensors — FaradaIC Sensors is to commoditize gas sensors and provide flexible gas sensing at a cheap cost for the expanding market of IoT applications.

Portfolio highlights

• Variational — Go long or short with leverage on memecoins, DEX pairs, pre-launch tokens, points markets, and more.
• Hyperdrive — The liquidity layer for RWAs. Scaling lending by eliminating the need for oracles, AMMs, and external liquidators.
• Open Campus — The Open Campus is a community-driven protocol that leverages the power of blockchain and invites all to build the future of education by putting the power of learning back in the hands of educators, students, and the community.

Portfolio highlights

• Neosoul — NeoSoul uses an open architecture with autonomous agents operating under user-defined constraints to link agent intelligence, deterministic capital controls, and verifiable market execution.
• ORO — ORO is an AI-powered DeFi companion that lets users manage, trade, stake, lend, and research crypto assets through natural-language conversations, ORO aims to simplify onchain finance by bringing portfolio management and DeFi actions into one conversational interface.
• GAEA — GAEA is a decentralized artificial intelligence training network and data infrastructure platform focused on building a comprehensive multimodal emotional database.

Portfolio highlights

• OP_NET — OPNET is a Bitcoin Layer 1 metaprotocol that enables smart contracts to function directly on the Bitcoin blockchain, without the use of sidechains or Layer 2 solutions.
• Modveon — The verified operating system for the modern nation state. Digital identity. Trusted communities. Sovereign financial rails. AI-native services.
• BridgePort — Crypto institutional middleware for off-exchange settlement. BridgePort's coordination layer connects exchanges and custodians for trading firm interoperability

Portfolio highlights

• Magma — Native liquid staking and MEV, powered by the fastest block engine in crypto. Earn yield and points, live on @Monad Mainnet.
• Rover — Bitcoin Liquid Staking on @BotanixLabs
• Neptune Protocol — Neptune Protocol is a decentralized lending platform. It enhances capital efficiency by enabling customers to obtain liquidity in a secure manner.

Portfolio highlights

• AEON — Powering #agenticeconomy #x402 | AEON is settlement layer bridging autonomous AI interactions (A2A & A2M) with real-world value flows. Backed by @yzilabs $AEON
• Slinky Network — Slinky Network provides an on-chain marketplace and payment protocol that connects AI agents and applications with third-party APIs. The company offers the SlinkyLayer platform, which wraps developer endpoints as discoverable skills and exposes them through an x402 pay-per-execution interface. Each API call triggers a non-custodial on-chainmicropayment, settling in the same request loop using networks such as Base and BNB Chain. Developers set prices, earn a defined revenue share, and receive instant payouts to their wallets without subscriptions or custodial holds. AI agents authenticate via wallet signatures, enabling autonomous, machine-to-machine access and payment without traditional logins or credit cards. The platform also records call ratings on-chain to provide portable, verifiable reputation for services.
• Shanghai Molian Technology — Shanghai Molian Technology is an intelligent agent communication infrastructure platform

Portfolio highlights

• Chomp — Chomp is a social network platform that focuses on on question-and-answer with prediction-based systems.
• Techdollar — Techdollar operates a private credit platform that originates and underwrites loans secured against private company equity. The service enables late-stage startup founders, employees, and institutional investors to unlock liquidity from their shares without triggering a taxable sale or losing long-term upside.
• ARO Network — ARO Network is a decentralized edge cloud platform focusing on power peer-to-peer content delivery.

Portfolio highlights

• Tea — Learn more about the tea protocol and how to unlock the rewards for previous and future open-source software contributions.
• Web3Auth — Web3Auth is simple, non-custodial auth infrastructure that enables Web3 wallets and applications to provide seamless user logins for both mainstream and native Web3 users.
• NexGen Cloud — Discover NexGen Cloud's innovative AI cloud solutions designed for seamless scalability, high performance and robust security. Lead AI innovation with NexGen Cloud.

Portfolio highlights

• Sepana — Sepana develops search technologies designed to make it easy for people, communities, applications, and protocols to discover Web3 content. Founded in 2021, Sepana's API allows developers to build search-as-a-service functionality directly into their apps.
• Mauve — Fully Compliant, Non-Custodial Exchange
• Center — Start point for your next NFT app.

Portfolio highlights

• Nada — Finance, Invest and Bank your real estate.
• DigiBuild — Automate your construction supply chain with AI.
• Upright — Meet Upright, the good for you go-to. Our first product is a category-defining high-protein, allergen-free Instant Oatmilk in three creamy, delicious flavors: original, vanilla, and chocolate. Each tasty cup of our oatmilk packs the same key nutrients as dairy, without the unwanted allergens or environmental impact.

Portfolio highlights

• Abartys Health — abartysHealth provides simple, smart and secure healthcare data management solutions for life sciences companies, health plans and patients
• San Jorge Children & Women's Hospital — San Jorge Children & Women's Hospital provides health care to children and women and enables excellent services to all patients.

Portfolio highlights

• Tea — Learn more about the tea protocol and how to unlock the rewards for previous and future open-source software contributions.

Portfolio highlights

• Tea — Learn more about the tea protocol and how to unlock the rewards for previous and future open-source software contributions.

Portfolio highlights

• Techdollar — Techdollar operates a private credit platform that originates and underwrites loans secured against private company equity. The service enables late-stage startup founders, employees, and institutional investors to unlock liquidity from their shares without triggering a taxable sale or losing long-term upside.
• Optimum — The Universal Data Acceleration Network | Powered by RLNC
• Doppler Finance — Rebuilding Capital Markets for the Tokenized Era.

Portfolio highlights

• Key Media — Key Media is an events and niche publishing company.
• Veridic Solutions — Veridic is a leading developer of cloud-based software. We combine talented minds with learning and innovation to solve the most complex issues. Our cloud certified engineers are uniquely positioned to serve your cloud projects
• Mobile Vascular Physicians — Mobile Vascular Physicians is a concierge vascular and interventional service (commonly called 'Special Procedures'), with a concentration in lower extremity venous and arterial disease.

Portfolio highlights

• IMUA — Follow us @imua
• Orb Labs — We make any transaction gasless and bridgeless, restore fungibility and fluidity of stablecoin, and connect onchain accounts with the offchain world.
• Flare Network — Flare is a full-stack layer 1 solution designed for data intensive use cases.

Portfolio highlights

• Novastro — Building the PayFi layer for stablecoin-powered payments, settlement, and real onchain financial utility.
• Shiba Inu Coin — Shiba Inu Coin is an Internet Publishing Company.
• Router Protocol — Router Protocol is a Cross Chain Bridge. Currently live on Ethereum, Polygon, and more. Building an interoperable cross chain future of the blockchain ecosystem.

Portfolio highlights

• RED Atlas — RED Atlas offers a platform that gives real estate data and insight to people working in the property market. It provides tools that let professionals find detailed information about individual properties and trends in the market. Atlas Professional is a product on the site that gives real-time property data, news, and analytics for brokers,investors, and agents. The platform lets users search property records and generate reports that help in planning and decision-making. It makes it possible for people to filter property information and create lists that fit specific needs. The service also supports sharing property details in formats that others can review.
• Alife — Alife is building technology for both clinics and patients.
• Druid Software — Druid are the leading provider of Private 5G Networks, Private 4G Networks and LTE Private Networks with their Private Core Network Platform Raemis.

Portfolio highlights

• Tea — Learn more about the tea protocol and how to unlock the rewards for previous and future open-source software contributions.

Portfolio highlights

• Murmuratto — Get 1% Better Everyday. Workflow software that drives Innovation + Operational Excellence for manufacturing and regulated industries.
• Seis Dedos Studio — Estudio Seis Dedos is a creative studio that specializes in developing ideas through various design and digital services. Their expertise includes web development, editorial design, corporate identity, animation, illustration, online advertising, and digital marketing. They work on projects such as websites, eCommerce platforms, brand identity, andinfographics for clients like Hómini Studio, IPJ, Centro Latinoamericano de Juventud, and Estudio Ferrer Napoleone. Overall, they offer comprehensive creative solutions to help brands build their visual presence and marketing strategies.
• Inmigración Virtual — Virtual Immigration is a law firm that offers immigration services in the United States and Puerto Rico, both virtually and in person. Its purpose is to provide accessible and secure assistance to people from all over the world interested in obtaining immigration relief in the U.S.

Portfolio highlights

• Wizzwoods — 1st pixel farm game integrates interchain capabilities with a SocialFi twist.
• SuperIntent — SuperIntent is a cryptocurrency AI app that streamlines on-chain earning tactics. Developed on a multi-agent framework with abundant yield sources.
• SuperGaming — At SuperGaming, we are putting India on the global gaming map.

Portfolio highlights

• RED Atlas — RED Atlas offers a platform that gives real estate data and insight to people working in the property market. It provides tools that let professionals find detailed information about individual properties and trends in the market. Atlas Professional is a product on the site that gives real-time property data, news, and analytics for brokers,investors, and agents. The platform lets users search property records and generate reports that help in planning and decision-making. It makes it possible for people to filter property information and create lists that fit specific needs. The service also supports sharing property details in formats that others can review.
• Nauta — The context that took decades to build now runs your supply chains 24/7. Nauta's AI agents act on your operational brain so your team decides what matters.

Portfolio highlights

• LYNC — The first consumer centric Layer 2 on Move
• Releap Protocol — Releap Protocol is a decentralized social graph on Sui
• Scallop — Scallop is the pioneering Next Generation peer-to-peer Web3 Decentralized Finance lending Money Market.

Portfolio highlights

• Decent Labs — We are rebuilding trust in technology. Decent Labs is developing a more transparent and equitable society by creating startups at the cross-section of financial technology and digital rights.
• Flowcarbon — Flowcarbon's versatile team merges investment banking, project finance, tax credit and other financial markets expertise to streamline access to creative capital solutions for the world’s most innovative companies in the infrastructure, decarbonization, and other niche sectors. Flowcarbon is headquartered in New York, United States and wasfounded in 2021.
• IntentX — The Future of Decentralized Derivatives

Portfolio highlights

• Digs — Digs is an easy-to-use collaboration software solution for professionals in residential home building that provides more efficient file storage, collaboration, and homeowner handoff for home construction projects. Try Digs for free today!
• Shoutcast Net — Stream from any device & protocol to any device & protocol. Very low latency 3 sec. AutoDJ & restream to Facebook, Twitch, YouTube included. 7 days trial!
• Midsummer Studios — Midsummer Studios is a independent, well-funded and committed to building a new kind of studio.

Portfolio highlights

• IMUA — Follow us @imua
• Wert — Making purchasing of NFTs seamless and not requiring users to have crypto.
• Outland — Criticism and conversations about art, technology, and NFTs

Portfolio highlights

• Docker — Docker is a platform designed to help developers build, share, and run container applications. We handle the tedious setup, so you can focus on the code.
• Aleo — Welcome to Aleo. The first platform for fully private applications. Write, run, and host private applications on Aleo. The ultimate toolkit for building private applications is finally here.
• Badger DAO — A community of builders bringing Bitcoin to DeFi

Portfolio highlights

• Tea — Learn more about the tea protocol and how to unlock the rewards for previous and future open-source software contributions.
• Casper Labs — Casper Labs powers scalable, secure & decentralized blockchain solutions for businesses, with the most flexible and customizable architecture on the market

Portfolio highlights

• IMUA — Follow us @imua
• Exocore — Exocore is the layer one blockchain for aggregated security.
• Voyage — The full stack AI GTM solution. We help your brand grow on autopilot.

Portfolio highlights

• IMUA — Follow us @imua
• Exocore — Exocore is the layer one blockchain for aggregated security.
• Valinor — Institutional capital solutions at the intersection of credit and blockchain

Portfolio highlights

• InsideDesk — Reduce AR days, boost collections, and streamline billing operations with InsideDesk's centralized revenue cycle management platform.
• CWX — CLOUDWERX provides elite engineering resources to accelerate your business.
• Lightworks — Lightworks is a Canadian consulting company that focuses on enterprise AI infrastructure and control systems. The company works with the biggest and most regulated companies in the world to plan, manage, and safeguard AI-powered systems.

Portfolio highlights

• Cookd — Cookd provides step-by-step cooking lessons and kits for kitchen meals.
• Nyayanidhi — Reforming India's Litigation/Judicial System
• Quash — Quash is a developer tool built to automate the bug reporting process by capturing screenshots, recordings, crash logs, and more.