Top 30 Software Startup Investors in Puerto Rico in May 2026

Portfolio highlights

• Quibble — Price Optimization and Revenue Management Software and Consulting For Vacation Rentals & Alternative Accommodations - We created Quibble to address the gap in the market between the simple rules-based software applications currently available and a truly science-based optimization. Quibble bundles our software with a full service offering togive our clients complete Pricing Ease of Mind. With many years of revenue management experience in the travel and hospitality industries, we know the pains and uncertainty revenue management brings. At Quibble, we aim to increase your revenue performance by engineering and implementing your custom pricing strategy while developing long-lasting partnerships.

Portfolio highlights

• Cropify — Eliminating subjective testing from the classification process using AI and machine learning. Cropify.io
• Flint — Introducing a new battery technology designed for sustainable energy solutions. Explore our innovation and its impact on the future of energy.
• Cellivate Technology — Startup, with proprietary platform technologies and products that enable cellular meat companies to accelerate the growth of cells

Portfolio highlights

• Hyperion — Join the Hyperion waitlist today to access the only bank account your business will ever need.

Portfolio highlights

• Rhuna — Rhuna is an AI and blockchain platform that transforms event management with NFT ticketing and token rewards.
• Lympid — We believe that anyone should have access to the amazing opportunities found on the blockchain, from DeFi protocols (aave, compound, yearn…) to Crypto Indexes, there's so much to discover! At Lympid you will be able to do it all easily in the same app, and directly through EUR.
• BRC20.com — BRC20.com is a decentralized finance infrastructure that incorporates features allowing users to engage in the cryptocurrency market.

Portfolio highlights

• IMUA — IMUA is a Layer 1 blockchain that provides shared security by combining decentralized security from well-known blockchains.
• Exocore — Exocore is the layer one blockchain for aggregated security.
• Doppler Finance — Doppler Finance is a yield-earning platform that unlock earning opportunities within the XRPL ecosystem

Portfolio highlights

• Everlyn — Everlyn is a Web3 video AI model that generates a decentralized infrastructure layer for autonomous video.
• Voyage — Voyage AI is an AI infrastructure project building the first GEOFi network to make AI-generated content citable.
• Cold River Games — Crystalfall is an upcoming free online action RPG with customizable skills and an endless endgame, set in a steampunk world.

Portfolio highlights

• GAM3S.GG — Discover 1,500+ games with honest reviews, expert guides, and daily gaming news across PC, console, and mobile. Find your next favorite game on Steam, Epic Games, PlayStation, Xbox, and Nintendo.
• CARV — CARV enables AI Beings to live, evolve, and govern as sovereign intelligences on-chain; not as tools, but as beings that act, learn, and lead.
• Nest Wallet — A Wallet Built for Traders

Portfolio highlights

• ARO Network — ARO Network is a decentralized edge cloud platform focusing on power peer-to-peer content delivery.
• Silhouette Exchange — Silhouette is a privacy-focused decentralized trading protocol integrated with the Hyperliquid ecosystem.
• Impossible Cloud Network — Impossible Cloud Network (ICN) is the foundational layer for the next-generation internet — a decentralized, composable cloud infrastructure serving AI, Web3, and enterprise applications. Unlike siloed DePIN projects or centralized incumbents, ICN delivers a high-performance, permissionless platform integrating storage, compute, and networking.With $31M in total funding, enterprise-grade architecture, 1,000+ B2B clients, and 28,000+ hypernodes sold, ICN is uniquely positioned to outcompete traditional cloud services and power the future of decentralized infrastructure. ICN is community-owned, performance-optimized, and regulation-aligned — bridging real-world adoption with blockchain innovation.

Portfolio highlights

• Axal — Earn competitive returns on your crypto with institutional-grade DeFi strategies, non-custodial security, and seamless user experience.
• Hemi Labs — Hemi (https://hemi.xyz) is a modular protocol that integrates Bitcoin and Ethereum to amplify and extend the core capabilities of the two leading blockchain networks. This offers a novel perspective on blockchain interoperability and scaling by approaching Bitcoin and Ethereum as components of a single supernetwork. The result providessecurity that exceeds that of Bitcoin (“superfinality”) and new levels of blockchain programmability, portability, and potential. Hemi was co-founded by Jeff Garzik (former Bitcoin core developer) and Max Sanchez (inventor of the Proof-of-Proof consensus protocol), and is surrounded by a team of renowned blockchain engineers, strategic partners and investors.
• Nexio — Nexio is a bitcoin scaling solution platform that helps to improve cryptocurrency's scalability by using parallelizing Bitcoin rollouts.

Portfolio highlights

• Exocore — Exocore is the layer one blockchain for aggregated security.
• Digital Harmonic — Digital Harmonic delivers AI-Driven software solutions with media, image and signal processing innovations. We empower commercial, government, and healthcare sectors with cutting-edge AI technology, delivering advanced software solutions to elevate clarity, precision, and mission-critical outcomes.

Portfolio highlights

• Valpas — Valpas is the hygiene protocol that reassures your future guests and keeps your hotel clean from the most uncontrollable: bed bugs
• Retorna — Retorna is an application for online money transfers and payments.
• Moonflow — Mejora tus procesos de cobranzas y ahorra hasta un 75%. Software de Gestion de Cobranzas para Empresas,

Portfolio highlights

• Mytra — Supercharged Industrial Productivity with Bots, Software, and Cells
• Tokemak — Automated DeFi Yield Farming & Liquidity Management
• Coop Records — Coop Records Music

Portfolio highlights

• IMUA — IMUA is a Layer 1 blockchain that provides shared security by combining decentralized security from well-known blockchains.
• Exocore — Exocore is the layer one blockchain for aggregated security.
• Voyage — Voyage AI is an AI infrastructure project building the first GEOFi network to make AI-generated content citable.

Portfolio highlights

• Civil — A starter blog demonstrating what Gatsby can do.
• Trustology — FCA registered & award-winning custodian Trustology safeguards & administers cryptoassets across blockchains, exchanges & DeFi protocols for institutions.
• SharpLink — SharpLink is an online technology company that works with sports leagues, fantasy sports sites, and sports media companies.

Portfolio highlights

• Docker — Docker is a platform designed to help developers build, share, and run container applications. We handle the tedious setup, so you can focus on the code.
• Aleo — Welcome to Aleo. The first platform for fully private applications. Write, run, and host private applications on Aleo. The ultimate toolkit for building private applications is finally here.
• Badger DAO — A community of builders bringing Bitcoin to DeFi

Portfolio highlights

• DoubleZero — DoubleZero is developing a global fiber network intended for high-performance distributed systems and blockchains. It seeks to enhance blockchain performance by establishing a dedicated physical infrastructure layer for communication.
• Pointsville — Empowering businesses to efficiently create, manage and service digital assets and loyalty programs, driving innovation and inclusion.
• Plume Network — Plume is the first modular L2 blockchain for RWAs that simplifies onchain asset deployment while fostering a composable ecosystem through DeFi applications

Portfolio highlights

• Vend Park — Unlock the true value of your parking asset with a fully digital parking access and revenue control system
• Wolf — Get all the tools and expertise you need to launch your own branded on-demand staffing platform, SpaaS and apps.
• Dataplor — Leveraging machine learning, AI, and human capital, dataplor delivers verified international places data to the world's leading companies.

Portfolio highlights

• Transak — Transak offers a simple integration to allow your users to buy more than 100+ cryptocurrencies with credit/debit cards, or bank transfers in more than 120+ countries.
• Agents World — Agents World operates as an web3 AI firm.
• Ooga Booga — Multichain Liquidity Aggregator

Portfolio highlights

• Atomionics — Atomionics is building atomic sensors for navigation and resource exploration. Sensing technology is severely inadequate for a lot of applications navigation and positioning, pinpointing oil and gas reserves, tunnel detection etc. Atomionics builds atomic sensors harnessing quantum mechanical properties of the atoms. This enables measurement ofparameters like gravity, acceleration and rotation with 1000x higher precision and accuracy than the current state of the art, leading to a completely new way of global positioning, and resource exploration.
• Integriculture — Integriculture makes cellular agriculture products to improve sustainability, food security, and reduce public health problems. The company offers a developed patented general-purpose large-scale cell culture system that can culture wide range of cells without external addition of expensive growth factors and provide consumers with affordable cleanmeat.Founded in 2015, Integriculture is headquartered in Tokyo, Japan.
• JumpStart Fertility — Jumpstart Fertility is investigating novel techniques to aid patients in starting or continuing to increase their families, including approaches that address the effects of biological aging on assisted reproduction. We want to increase IVF success rates so that patients need fewer cycles to get a healthy pregnancy. Our research focuses onenhancing egg quality and embryo development in IVF cycles in later age groups, where IVF success rates tend to drop, necessitating repeated rounds under existing standards of care.

Portfolio highlights

• Influur — Access the global creator community instantly and collaborate at scale with our end-to-end solutions.
• Conectamos — Ship with local carriers, more affordable and reliable
• PayMon — PayMon integrates an ERP software with a user-friendly digital wallet for seamless payment processing, top-ups, and much more.

Portfolio highlights

• CELL Studio — A blockchain software development company with a dedicated focus on the BTC ecosystem, committed to advancing the Nervos BTCKB initiative
• Avalon Finance — Institutional Bitcoin-backed lending, borrowing, earning, and liquidity. Fully on-chain and regulatory-compliant.
• Stoneblade Entertainment — Stoneblade Entertainment operates as a publisher of strategy games.

Portfolio highlights

• Ballet — Ballet Crypto is a companion mobile app, which enables sending of cryptocurrency, checking market value and activating additional currencies. The use of the mobile app is completely optional, as you do not need it to receive and store your cryptocurrency safely.
• VirgoCX — We make crypto trading safe, easy, and affordable for Canadians. Buy Bitcoin, Ethereum and 60+ Cryptocurrencies with competitive pricing, Free cash in and out, instant funding, and timely customer service.
• MIDL — MIDL is a digital finance company that offers EVM compatibility, functionality of Ethereum dApps to Bitcoin users.

Portfolio highlights

• IMUA — IMUA is a Layer 1 blockchain that provides shared security by combining decentralized security from well-known blockchains.
• Exocore — Exocore is the layer one blockchain for aggregated security.

Portfolio highlights

• Due — Discover our global payment platform. Powered by open, decentralised and interoperable networks.
• Freename — Register Web3 domains, custom TLDs, or import domains. Secure your digital identity today.
• BIO Protocol — The BIO Protocol (BIO) allows onchain scientific communities to fund, build, and co-own research and products in specific biomedical domains including lifespan, brain health, and rare disorders. BIO, founded by senior VitaDAO members, empowers worldwide communities of scientists, patients, and investors to take science into their own hands andbring solutions to life more effectively than traditional pharmaceutical companies.

Portfolio highlights

• Hyperion — Join the Hyperion waitlist today to access the only bank account your business will ever need.

Portfolio highlights

• Kiwi — Kiwi is a fintech dedicated to helping Latinos build credit history and improve financial literacy.
• Hyperion — Join the Hyperion waitlist today to access the only bank account your business will ever need.
• Ole Insurance Group — Ole Insurance Group focuses on offering protection and well-being products and services through technology. Ole Insurance Group was founded in 2021 and was headquartered in Puerto Rico.

Portfolio highlights

• Kapkap — Kapkap is a web3 platform that uses AI for attention based value distribution in gaming.
• BullPerks — BullPerks is a community of like-minded individuals who want to leverage their power and invest together in the best projects on equal terms with VCs.
• Mythic Protocol — The Central Hub for Mythic Operatives to conduct their operations

Portfolio highlights

• Quibble — Price Optimization and Revenue Management Software and Consulting For Vacation Rentals & Alternative Accommodations - We created Quibble to address the gap in the market between the simple rules-based software applications currently available and a truly science-based optimization. Quibble bundles our software with a full service offering togive our clients complete Pricing Ease of Mind. With many years of revenue management experience in the travel and hospitality industries, we know the pains and uncertainty revenue management brings. At Quibble, we aim to increase your revenue performance by engineering and implementing your custom pricing strategy while developing long-lasting partnerships.
• ClassCalc — Students can use their smartphones instead of using or buying a TI calculator, and teachers can ensure they only use the ClassCalc calculator app in class. We believe students and teachers should have a choice other than the same expensive, difficult to learn and use dedicated-purpose TI calculator they have been forced to use for decades.ClassCalc provides a multi-subject math calculator with scientific, graphing, and matrix functionality in an easy-to-use smartphone app. Teachers are able to lock down the student’s phone to only the ClassCalc app for class time, quizzes, tests… no cheating or outside distractions (social media, texting etc).
• Turno, formerly TurnoverBnB — Find now a local Airbnb cleaning service; automatically schedule your existing cleaners. Integrated with all reservations platforms and channel managers.

Portfolio highlights

• Exocore — Exocore is the layer one blockchain for aggregated security.
• Exabits AI — Exabits' network of GPUs ranges from consumer-grade to H100s, offering the most cost-effective compute because we are obsessed with innovating performance.

Portfolio highlights

• TACEO — TACEO refers to MPC encrypted compute for Web3.
• Due — Discover our global payment platform. Powered by open, decentralised and interoperable networks.
• Freename — Register Web3 domains, custom TLDs, or import domains. Secure your digital identity today.