Top 50 Blockchain Startup Investors in Spain (September 2026)

Portfolio highlights

• Dolfin — The first agentic sales commission platform. Automate payouts, drive rep motivation, and eliminate the Black Box.
• Inventia Kinetics — Inventia Kinetics specializes in the design, analysis, and manufacture of equipment and assembly tools for electronics sector.
• Telum Therapeutics — Telum Therapeutics is a biotechnology company that develops new treatments for infectious diseases based on the use of lytic enzymes from bacteriophages.

Portfolio highlights

• Tolemy Bio — The AI-native virtual cell platform for therapeutic development and manufacture.
• Charms — Charms AI is an on‑chain mobile application focused on AI characters with persistent memory and user‑facing economies. The platform allows creators to build AI characters that can maintain long‑term conversational context and have their own wallets and tokenized assets, while users interact with, back, and trade around those characters. It sits atthe intersection of AI‑driven interaction, gaming‑style engagement, and blockchain‑based tokenization, with the overall design geared toward converting user attention and interaction into on‑chain economic flows.
• Balance — Balance is a private digital health company based in Spain that operates in the clinics and outpatient healthcare services sector. company's core mission is to provide an integrated, medical, and sustainable approach to treating obesity and overweight conditions. Moving away from traditional restrictive diets, the company leverages asubscription-based telehealth model combined with clinical pharmacology.

Portfolio highlights

• Kintai — Kintai's a lending platform aiming to help small and medium companies with their funding needs. Based on a merchant cash advance model, companies can return their loans on a daily basis with low frictionless amounts.
• Covides — Covides is a prominent Spanish wine cooperative that integrates grape production, vinification, and international commercial distribution for local winegrowers.
• ATTSU — ATTSU is leader manufacturer of industrial steam boilers, thermal oil boilers and superheated water boilers. Available on a wide variety of fuels.

Portfolio highlights

• Numentech — Numen was born to bring to the market products and solutions that guarantee full security at any time, in any environment in addition to safeguard the full operability of ITC. In order to reduce the cybersecurity vulnerability we work from a holistic and resilient perspective. The integrated mix of products and services developed by Numen, coversall levels that make up the ITC dynamic ecosystem: people, policies, organization culture and technology. Numen is the ideal partner for the verification, design, and implementation of global cybersecurity into corporate or domestic frameworks. Our team is our mainstay. We are focused on creating continued opportunities to see our team develop and grow professionally, including them in I+D project to develop new cybersecurity solutions.

Portfolio highlights

• Citring — Citring One, is an innovative juicer with a radically simplified process. Effortless from juicing to cleaning, it is ideal for anyone with a busy lifestyle. Say goodbye to hassle and hello to fresh juice. With Citring One, juicing is as easy as pressing a button.
• Trak — Trak is a software tool for healthcare professional to provide AI-based tele-rehabilitation services like physiotherapy and others.
• Cocircular — Cocircular is a Construction Company.

Portfolio highlights

• UMNAI — UMNAI helps organisations build, deploy and govern explainable AI decision systems for high-impact environments.
• Skarbe — Skarbe has officially wound down operations as of April 2026. Thank you for being part of our story.
• STAMP — STAMP redefines Tax-Free in Europe. Instant VAT exemption for travelers. More sales, transparency, and control for merchants.

Portfolio highlights

• TrueDAO — TrueDAO is a new-generation AI-native decentralized autonomous financial infrastructure. Built on the underlying logic of DAO community co-governance, it leverages smart contracts to construct an on-chain financial system integrating AI algorithm scheduling, staking, and dynamic protection. It optimizes economic parameters and asset strategies inreal time via AI models, delivers low-volatility and sustainable value growth paths for digital assets, and pioneers an innovative paradigm of autonomous finance.
• Cryopets — Pausing biological time with cryosleep for pets
• Share — From subsea cables to last-mile networks, Share coordinates fragmented infrastructure into a single ecosystem.

Portfolio highlights

• Tea-Fi — Tea-Fi is an all-in-one decentralized finance (DeFi) platform that turns complexity into opportunity.
• Finceptor — Become an early investor of Web3's top projects with over 250,000 other backers.
• web3intelligence — Build wealth and trust in the world of crypto with intelligent financial tools, data and infrastructure.

Portfolio highlights

• Arq — Arq is a Spanish quantum technology startup that develops networking hardware for the quantum internet.
• LuxQuanta — Quantum Key Distribution or Quantum Cryptography provides long-term and future-proof data protection.
• Tolemy Bio — The AI-native virtual cell platform for therapeutic development and manufacture.

Portfolio highlights

• 1mpact Revolution — We are providing technological tools, vision and other support that enables social, economic, cultural, environmental change.

Portfolio highlights

• BEONx — Beonprice is one of the Travel Tech companies in Spain, committed to leading the future of revenue strategy. Agility, innovation and organization are the engines of the brand, with the aim of offering profitable innovation and being part of the DNA of each of its customers. Beonprice has developed HQI™, the only index in the hotel market thatmeasures the integral quality of a hotel in order to understand the competitive position and price elasticity of the demand in the market. Beonprice has more than 2,000 customers in more than 30 countries. Its RMS is successfully used by growing hotel chains such Bluebay, Hotelatelier, Iberostar, RIU, Labranda Hotels & Resorts, HM Resorts, Park Royal, Dreamplace, Catalonia, Room Mate, Orchid Hotels and many others.
• Articul8 — The Domain-Specific GenAI Platform, Purpose-Built for Your Data and Mission
• Flora — Flora Fertility is dedicated to empowering the next generation of parents by putting the control of reproductive health outcomes back where they belongs—in your hands. It aims to revolutionize how women's health and family building are approached, making fertility care more accessible, transparent, and personalized. By reimagining thefinancial and medical aspects of family planning, we help you navigate the journey to parenthood with greater confidence, ease, and support, ensuring that your fertility choices align with your personal goals and circumstances.

Portfolio highlights

• Credbull — Credbull manages on-chain private credit funds that provide vital financing solutions to creditworthy small and medium-sized enterprises (SMEs).
• Ink Finance — Ink Finance is the scalability solution for web3 DAOs, protocols and asset managers, enabling them to customize asset management and governance frameworks through a no-code interface, to effectively establish on-chain credit and financial competence. Ink Finance allows a one-stop and frictionless solution for organized financial activities, with scalability and customizability.
• Velvet Capital — Velvet Capital is a DeFi operating system that helps launch and manage on-chain funds and structured products. Velvet Capital offers its users a way to gain exposure to digital assets.

Portfolio highlights

• Rauda AI — Rauda is an artificial intelligence platform specialized in automating customer service with the best customer experience. Take a quantum leap in productivity, reduce costs and improve customer satisfaction with the power of generative artificial intelligence.
• Aino — AI-powered spatial analytics platform for architecture, urban planning and development teams. Site analysis, GIS-free mapping and location intelligence. 400+ cities covered.
• Orbital Paradigm — Orbital Paradigm builds reusable vehicles that carry cargo to space and bring it back. Dedicated missions, any orbit, on your schedule. Based in Madrid.

Portfolio highlights

• Enjinstarter — Web 3.0 Entertainment, Sports, Fashion, Metaverse, Social, Gamefi & Gamified Utility
• Zeitgeist PM — Zeitgeist PM is a blockchain tech to facilitate prediction markets and the futarchy form of governance.
• Genesis Shards — Crafting a whole new suite of NFT powered products across multiple blockchains

Portfolio highlights

• Akave Cloud — The Al-Ready Sovereign Cloud | Own your data. Control your costs. A modern S3-Compatible object storage.
• Hemispheric — Hemispheric develops fundamental AI technologies aimed at deciphering brain activity for innovative applications.
• Synchron — The endovascular brain computer interface.

Portfolio highlights

• Bloom — Moved to @bloomsocial
• Lemon Cash — Lemon Cash is digital wallet with FIAT and crypto capabilities. End to end digital ecosystem for Latin America.
• RISE Chain — RISE is a next-generation Ethereum Layer 2 blockchain designed to redefine blockchain performance by delivering near-instant transaction confirmations at unprecedented scale, all while upholding Ethereum’s foundational principle of decentralization

Portfolio highlights

• Mento Labs — Mento is bringing FX onchain. We provide institutions with access to onchain FX at real-world rates.
• Learn.xyz — Learn.xyz’s is a mixture of Duolingo and Wikipedia, powered by AI, creating bite-sized “Curiosities” which feature slides and a quiz, in mere seconds just from taking in a user’s question. Find the app on iOS and Android.
• Thrive Protocol — Thrive Protocol's vision is to maximize value creation for all people and communities.

Portfolio highlights

• RepScan — RepScan is an eliminate the negative that the Internet says about you. Rapid negative reputation detection and removal technology.
• YPLASMA — At YPlasma, we are pioneers at the development of cutting-edge plasma actuators.
• Pack2Earth — Pack2Earth, S.L. is a company that specializes in developing new, sustainable materials for the food sector and other industries.

Portfolio highlights

• Buildpeer — Buildpeer is a project management software for construction fields. The company was founded by Mauricio Valdes in 2021 and is headquartered in Garza García, Nuevo Leon, Mexico.
• Hotelverse — Hotelverse allows customers search over hotels on their platform and book rooms as per their requirements.
• Savana — Electronic Health Records reuse, with Clinical Natural Language Processing.

Portfolio highlights

• Energiot — Energiot specialized engineering service in energy harvesting, self-powered devices, wireless sensor networks.
• DYNAMICS VR — Dynamics VR provides rehab software for clinics to tackle musculoskeletal pain and movement impairments caused by brain trauma.
• DARWIN Biomed — Biomedical Engineering

Portfolio highlights

• Flipflow — At Flipflow, we offer brands, manufacturers, and retailers an accurate, actionable, real-time snapshot of their products, competitors, and the market to facilitate informed business decisions. We gather millions of data points daily from retailers in markets worldwide. This data is processed, structured, and delivered as real-time actionableinsights through a flexible and powerful Business Intelligence (BI) suite. Our suite incorporates automations and AI-powered analytics, providing prescription capabilities that guide different teams within retail companies to make optimal business decisions. This approach not only offers a more holistic perspective for key decisions but also enhances day-to-day reaction capabilities.
• Kalipso — Kalipso automates regulatory compliance with smart mapping and policy update tools.
• Centinel — The accounting engine for modern finance teams.

Portfolio highlights

• Portal — Build next-generation cell engineering and drug discovery workflows with Portal mechanoporation for broad intracellular delivery across cells and cargoes.
• Superapp — Build iOS, Mac and Apple Watch swift native apps and games with AI. One click to App Store & ASO. Join Superapp Discord https://t.co/klNe8391Vw
• Portal AI — Personal AI agent that actually knows who you are

Portfolio highlights

• Zecrey — Zecrey is a digital asset privacy protocol provider, based on the application of the Sigma protocol.
• Vee Finance — Bridge the gap between traditional banking and crypto Defi Earn fixed/flexible return on deposited assets
• The Unfettered — The Unfettered is a blockchain PC game.

Portfolio highlights

• Sogni AI — Unleash creativity with the Sogni Supernet: a purpose-built DePIN protocol for Creative AI. Empowering Creative AI apps with unmatched speed and scale.
• Bondex — Join Bondex, a Web3 network with 4M+ users. Monetize connections, build your reputation, and earn $BDXN rewards. Advance your career or discover top talent now.
• Folks Finance — Folks Finance is a permissionless DeFi lending platform where users can lend and borrow crypto across chains, access loans, and manage digital assets in one unified liquidity protocol.

Portfolio highlights

• Outer Ring — Outer Ring is a play-to-earn MMORPG (Massively Multiplayer Online Role-Playing Game) video game in the science fiction and fantasy universe. The game model is freemium, i.e., the player can access and play from the very first moment without paying anything and can obtain benefits by earning achievements.
• 8 Securities — 8 Securities offered mobile-only investing, a robo-advisory service, a social trading platform, and zero-commission brokerage. Through the platform, members will be able to follow the investment portfolios of top-performing members of the community and learn what they are buying, selling, and holding. They will also see where their own performanceranks.

Portfolio highlights

• HUNTY — HUNTY is a platform that help people find jobs by connecting them with world class mentors who prepare them for the job search process. And people only pay when they get hired.
• Simetrik — Automate repetitive data reconciliation processes without any coding knowledge
• numia — numia (formerly Debmedia) is a B2B SaaS platform that helps industries manage customer journeys by seamlessly integrating online and offline experiences. By combining AI automation with human interaction, numia assists companies—including leading banks, insurance firms, telcos, healthcare providers, and retailers—to boost sales, optimize customerengagement, and enhance customer satisfaction.

Portfolio highlights

• TACMIND — Tacmind is an AI platform that helps companies understand how AI models perceive, describe, and recommend their brand. It analyzes how large language models and other AI technologies speak about a brand, detecting tone, emotion, and narrative. Tacmind provides insights that allow companies to see their brand's presence and reputation inAI-driven environments, benchmark against competitors, and optimize their brand assets and messages specifically for how AI systems view them. This helps companies influence and improve the narrative AI models generate about their brand to better control brand perception and increase visibility in AI-assisted searches and recommendations. Tacmind’s tools give companies a strategic advantage in the evolving landscape where AI plays a significant role in shaping consumer decisions and brand discovery.​
• Apartool — housing supplier with accommodation for staff
• Ezra AI Labs — Helping recruiting teams quickly screen and rank hundreds of applicants through customizable voice AI interviews.

Portfolio highlights

• Splitfy — Splitfy is the perfect app to collect money from your plans Group.
• Viterbit — Viterbit is a technology start-up that offers a Recruitment and Selection Software (ATS). Just what your company needs to go one step further with the talent it hires. The greatest strength organizations have are the people who work in them, so our team is committed to helping you attract the talent you need.
• Agroptima — Agroptima is a farmer-centric mobile-based farm management software that makes farms more profitable and easy to manage.We power farmers with software and data that lets them easily manage their farms from their smartphone and increase their profitability. Agroptima’s goal is to automate data collection by integrating its software with sensorsand other sources of vital data to farmers.We're building the future of agriculture. Challenged? Join our team!

Portfolio highlights

• HUBUC — A single API-platform that allows any business to embed financial services capabilities into their products. 
e.g Uber can issue branded credit cards for all Uber drivers and Walmart provides customers a simple way to better manage and control their everyday finances, with no regulatory burden or compliance requirements in a few weeks.
• Steryon — OT Cybersecurity | Cyber-Physical Systems | Risk Management | Critical Infrastructure Security | Vulnerability Remediation OT | AI in Cybersecurity |
• ZenRows — ZenRows is a next-generation Web Scraping API & Data Extraction tool that automatically turns HTMLs into structured data.

Portfolio highlights

• Zeemcoin — Great prices on a large selection of domains. Find the pefect domain for your new startup.

Portfolio highlights

• Internxt — Here at Internxt, we're helping shape an Internet that truly respects you. Our first service, Internxt Drive, is a free & fully private cloud storage service and is part of our disruptive cloud infrastructure. Distributed, Trustless. Switch for free.

Portfolio highlights

• Ordzaar — Ordinal Launchpad using the latest and greatest tech Bitcoin has to offer.
• Tren Finance — Tren Finance: a secure DeFi liquidity protocol offering seamless asset swaps, yield opportunities, and cross-chain compatibility through automated smart contracts, redefining liquidity for users and institutions.
• BLIFE Protocol — Bringing Web3 to Bitcoin with the backing of Animoca Brands. Merged with @Portalcoin

Portfolio highlights

• Runa — Runa provides solutions to increase conversions and maximize profits in real-time on online merchants' Websites. In 2008, more than $21 billion was spent on online marketing to drive traffic to online merchant Websites with mechanisms such as display ads, search optimization, lead generation, and affiliate marketing. However, conversion ratesof visitors to actual sales on the Website averaged only 2-3%. Over 97% of Website visitors dropped off without making a purchase. Runa allows online merchants to more than double the conversion rate of visitors. A one percentage point increase in conversions from visitors to sales among all the existing online merchants is equivalent to them spending approximately an additional $7 billion on online advertising at current efficiencies.
• Outer Ring — Outer Ring is a play-to-earn MMORPG (Massively Multiplayer Online Role-Playing Game) video game in the science fiction and fantasy universe. The game model is freemium, i.e., the player can access and play from the very first moment without paying anything and can obtain benefits by earning achievements.

Portfolio highlights

• MetaMall — Metamall will offer a unique virtual reality experience on the blockchain, allowing users to build, explore, and trade.
• Playermon — Playermoon is an NFT Game where anyone can explore and battle and earn NFTs.
• Vent Finance — The easiest way to research, apply, and purchase early crypto project tokens. Sign up and get started today.

Portfolio highlights

• Outer Ring — Outer Ring is a play-to-earn MMORPG (Massively Multiplayer Online Role-Playing Game) video game in the science fiction and fantasy universe. The game model is freemium, i.e., the player can access and play from the very first moment without paying anything and can obtain benefits by earning achievements.
• Infinity Arena — The place to connect players who love tactical card games or have passionate about collecting valuable and rare NFT cards.
• Ancient Kingdom — Ancient Kingdom is the first ancient martial arts game on the blockchain platform, pioneering the realization of real-time games on the blockchain platform.

Portfolio highlights

• Fermah — Programmable, async compute infra - powering next-gen apps, starting with @flashcastsocial. Find out more: https://t.co/6mWi2fPWpn
• Mythik — Mythik operates as an entertainment company with a vision to bring Eastern mythology, history and folktales.
• NovaNet — NovaNet offers local verifiable computing and privacy protection applications, including AI, decentralized Internet of Things (DePIN), and games.

Portfolio highlights

• Oumla — Secure, scalable blockchain infrastructure for businesses, enterprises, and governments to manage digital assets with ease and compliance.
• KOR Protocol — KOR Protocol is a decentralized intellectual property (IP) infrastructure designed to empower creators, protect rights, and enable seamless collaboration and monetization of IP assets across various industries, including music, film, TV, gaming, and art. Backed by notable entities like Animoca Brands, Republic, Niantic, Sfermion, Solana, andprominent creators such as Black Mirror, Disclosure, deadmau5, and Richie Hawtin, KOR leverages blockchain, AI, and DeFi to offer a transparent, efficient, and scalable environment for IP expansion.
• Forg3t Protocol — Forg3t Protocol provides provable AI unlearning infrastructure for enterprises. It enables verification and auditing of sensitive data removal from AI models. This ensures strong regulatory compliance. Built for secure, transparent AI data management.

Portfolio highlights

• Outer Ring — Outer Ring is a play-to-earn MMORPG (Massively Multiplayer Online Role-Playing Game) video game in the science fiction and fantasy universe. The game model is freemium, i.e., the player can access and play from the very first moment without paying anything and can obtain benefits by earning achievements.
• AAG Ventures — A bold new Saakuru Labs focused on incubating AI-native companies and game studios.

Portfolio highlights

• Tripjoin — Tripjoin brings together those who want to travel but don't have anyone to travel with. Everyone joined with the same goal of meeting new people and experiencing travel in a unique way.
• Uxia — Transform your research with AI-powered user testing, delivering high-quality UX/UI insights for Product Designers and UX Researchers. No recruiting needed.
• Mathew — Mathew is an educational platform that provides AI-powered software for teachers and students.

Portfolio highlights

• Shardeum — Shardeum is an EVM-based, linearly scalable smart contract platform that maintains low gas fees while providing true decentralization and solid security
• Paxo Finance — Supply single-sided liquidity to earn risk-free yield or use leveraged investment vaults to supercharge your DeFi strategies.
• Push Protocol — Push (Previously EPNS) | Communication Protocol of Web3

Portfolio highlights

• Naturr — Nature, which seeks to connect small-scale artisanal food producers from rural areas with urban consumers. Nature platform could serve as an important bridge for promoting local and sustainable food systems, benefiting both rural producers and urban consumers i
• Biotasmart — Plataforma que convierte datos de la microbiota intestinal en recomendaciones nutricionales personalizadas.
• DARWIN Biomed — Biomedical Engineering

Portfolio highlights

• 8Layers — 8Layers is an artificial intelligence platform that offers cloud identity threat detection to organizations
• Barbara — Barbara is the Cybersecure Industrial Edge Platform that enables companies to connect, deploy and scale gateways and edge applications in a few clicks
• iPronics — iPronics develops the innovative concepts of general-purpose integrated programmable photonic systems.

Portfolio highlights

• Outer Ring — Outer Ring is a play-to-earn MMORPG (Massively Multiplayer Online Role-Playing Game) video game in the science fiction and fantasy universe. The game model is freemium, i.e., the player can access and play from the very first moment without paying anything and can obtain benefits by earning achievements.
• Arker:The legend of ohm — Arker is a nonfungible token (NFT), a play-to-earn game that allows users to earn crypto and trade it for actual money. To fight for the city of Ohm, players must recruit heroes of different classes. As a result, they increase the loot of Arker, a mineral of great value. Fighting against another player allows earning tokens, which can be exchangedfor items, and playing player-versus-environment enables to earn rewards for items.

Portfolio highlights

• Outer Ring — Outer Ring is a play-to-earn MMORPG (Massively Multiplayer Online Role-Playing Game) video game in the science fiction and fantasy universe. The game model is freemium, i.e., the player can access and play from the very first moment without paying anything and can obtain benefits by earning achievements.

Portfolio highlights

• NFTPad — What is NFTPAD.FI NFT gaming. art. DeFi.NFTPad has been founded to aid the growth of the NFT Industry and Ecosystem in a safe and sustainable way. NFTPad allows users to mint NFTs in minutes, auction them or raise liquidity so that they may be traded on AMMs such as PancakeSwap and Uniswap. Launchpad for Blockchain
• DROP — DROP is an entertainment service intended to give a new shape to the music industry. They are defining the future of music ownership, distribution, and publishing via NFT standards, decentralized governance, and automated finance, providing audio creators with a new shape and sustainable future with their innovations.
• Cryptomeda — Own a valuable NFT card collection and start earning profit now! Find out more.

Portfolio highlights

• 1DOC3 — 1doc3 is a e-health platform that connects 490 million of Spanish speaking people with licensed and trusted doctors. Users find personalized answers to their health related questions. Doctors build their online reputation, find new patients and create the biggest health related questions and answers curated database in Spanish. The Platform isavailable via web, App, SMS and USSD, allowing the entire population to have access to a Doctor no matter where they are, or even if they don't have internet access.
• LetsData — LetsData is an AI-power radar against disinformation. LetsData provides real-time media and social media monitoring in over 50 countries, empowering state agencies, businesses, and civil societies to proactively navigate risks and seize opportunities in the face of disinformation.
• Quantum Bridge — Quantum Bridge is a pioneer in Distributed Symmetric Key Exchange (DSKE) technology. It offers quantum-safe cybersecurity products and services. Quantum-safe product and services, Quantum-safe roadmap and quantum-safe solutions implementation.

Portfolio highlights

• Banger — Banger is a blockchain-powered gaming platform that provides its users with an array of earning possibilities. Banger was founded in 2019 and was headquartered in Madrid, Spain.

Portfolio highlights

• Outer Ring — Outer Ring is a play-to-earn MMORPG (Massively Multiplayer Online Role-Playing Game) video game in the science fiction and fantasy universe. The game model is freemium, i.e., the player can access and play from the very first moment without paying anything and can obtain benefits by earning achievements.

Portfolio highlights

• Entravel — Market leading hotel distribution API & room mapping. Agentic interface for AI agents. Turnkey hotel booking white labels for businesses.
• Solana — Solana is the high performance network powering internet capital markets, payments, and crypto applications. Fast. Decentralized. Scalable. Energy efficient. Solana can power thousands of transactions per second.
• TrueNorth — The first Agentic Brokerage - build your own professional trading desk

Portfolio highlights

• RepScan — RepScan is an eliminate the negative that the Internet says about you. Rapid negative reputation detection and removal technology.
• Kimera Technologies — Kimera develops software solutions to understand visual content, extract its useful data and transform it into accessible information.
• Lookiero Outfittery Group — Check out all the roles at LOOKIERO OUTFITTERY GROUP. Get to know the team, see our offices, learn about our values, and discover the benefits of working at LOOKIERO OUTFITTERY GROUP