Top 50 Web3 Startup Investors in Cayman Islands (September 2026)

Portfolio highlights

• Ruvo — Cacao is a fintech platform that allows Brazilians to receive, store, spend, and withdraw USD instantly.
• Coop Records — Coop Records investing in next generation of music enabled by Web3.
• Limitless Labs — Trade on future outcomes with Limitless, a prediction market for crypto prices, sports matches, politics, and major world events.

Portfolio highlights

• Kontigo — We help underbanked gig workers in Latam build credit and access group financing where small groups of family or friends lend and save money together. Users can validate their income from multiple sources such as gig apps, catalog sales, and open finance (Uber, Rappi, Didi, Indriver, Avon, and all major banks). After verifying the income wedirectly offer them group savings and group loans, without leaving WhatsApp, their primary messaging app.
• Subzero Labs — Subzero Labs is developing Rialo, a developer-first Layer 1 blockchain built for internet-scale decentralized applications.
• Ceramic Network — We've joined @textileio to build the first open intelligence network for AI agents. Follow us there.

Portfolio highlights

• EarnOS — EarnOS is the fully remote company that provides Global Ad & Payments Platform powered by Web3.
• KOR Protocol — KOR Protocol is a decentralized intellectual property (IP) infrastructure designed to empower creators, protect rights, and enable seamless collaboration and monetization of IP assets across various industries, including music, film, TV, gaming, and art. Backed by notable entities like Animoca Brands, Republic, Niantic, Sfermion, Solana, andprominent creators such as Black Mirror, Disclosure, deadmau5, and Richie Hawtin, KOR leverages blockchain, AI, and DeFi to offer a transparent, efficient, and scalable environment for IP expansion.
• Freehand — AI Teams for Complex Spend Management

Portfolio highlights

• Morpho Labs — Morpho is an open credit network that connects lenders and borrowers to the best possible opportunities worldwide.
• Velocity — Velocity provides a unified platform for efficiently moving and managing funds across both traditional banks and blockchains.
• Silicon Data — Revolutionize compute markets through unparalleled data transparency, financial product innovation and market intelligence

Portfolio highlights

• BULK Trade — One Exchange Infinite Markets
• Pave Bank — The world's first multi-asset and programmable bank
• Nova Markets — The next billion-dollar market starts here. Powered by @HyperliquidX

Portfolio highlights

• Utexo — Instant, private USDT payments on Bitcoin. Move stablecoins the way you move money.
• Wave — Wave is a US blockchain SUI ecosystem that offers DeFi and GameFi products.
• Domin Network — Pioneering the Future of Multi Chain E-Commerce, backed by @animocabrands https://t.co/16gnnhOcLy

Portfolio highlights

• ARX — Secure chips, onchain. Creators of @useburner @offlinecashco @kongiscash.
• Squads — Collaborative infrastructure for web3 native teams
• Ceramic Network — We've joined @textileio to build the first open intelligence network for AI agents. Follow us there.

Portfolio highlights

• Cowboy Snake — Cowboy Snake is the TvT play-to-earn game inspired by snake on the blockchain. Cowboy Snake is a product of OrenCT Ltd.
• Formless — Formless enables gamers, NFT enthusiasts and digital collectors to find their favourite game while helping games find their targeted fans.
• Clear Protocol — Clear Protocol, Inc. is a healthcare IT company. Our product, Clear Protocol, is Software-as-a-service for hospitals, clinics, and medical offices.

Portfolio highlights

• TurboFlow — Trading, made simple. Everyone gets a seat at TurboFlow.
• World Foundation — World is a new standard of trust for the internet - private proof of human, powerful financial infrastructure & the human-first experiences they enable.
• Solana Company — Building the Preeminent Solana Treasury $HSDT

Portfolio highlights

• Soter Insure — Reliable insurance for the digital asset ecosystem.
• Ethereum Institutional — Accelerating institutional adoption of Ethereum
• Digital Prime Technologies — Full-Service Institutional-Grade Prime Brokerage for Digital Asset Management. DLCC offers full-service Prime Brokerage solutions for digital assets. Our all-in-one user interface leverages both API and Saas product offerings to connect clients with a growing network of liquidity providers to transact, borrow, and lend digital assets, and managecollateral. Our product suite also offers traditional Prime Brokerage services, such as consultation and capital introduction.

Portfolio highlights

• Akave Cloud — The Al-Ready Sovereign Cloud | Own your data. Control your costs. A modern S3-Compatible object storage.
• Hemispheric — Hemispheric develops fundamental AI technologies aimed at deciphering brain activity for innovative applications.
• Synchron — The endovascular brain computer interface.

Portfolio highlights

• Oh — The OpenAI of the spicy content industry, combining consumer platforms (@ohchatai | @ohdotfun) with infrastructure (https://t.co/BMwDSzAg14)
• Chance Studios — Every Collection Starts With A Chance
• Chance Studios — Every Collection Starts With A Chance

Portfolio highlights

• Deblock — Better than your bank: IBAN, Visa card, instant SEPA transfers, 4% a year, and a self-custody wallet for your crypto.
• Harbor — Future Proof Finance
• Dakota Ridge — Stablecoin infrastructure that enables global money movement.

Portfolio highlights

• Pally — Pally is an AI Agent for your network.
• twyne — Twyne operates a decentralized finance (DeFi) credit delegation protocol that routes underutilized borrowing capacity from collateral depositors directly to active market borrowers. The infrastructure functions as an intermediary aggregation layer on top of established lending markets to optimize credit distribution and maximize capital efficiency.
• TrueNorth — The first Agentic Brokerage - build your own professional trading desk

Portfolio highlights

• X10 — X10 operates as a hybrid crypto exchange provider.
• Trace Finance — Trace Finance enables secure and swift connections between businesses and their customers through payments and automatic transaction reconciliations on a large scale, promoting integrity and efficiency.
• Ceramic Network — We've joined @textileio to build the first open intelligence network for AI agents. Follow us there.

Portfolio highlights

• Freebird — Freebird is a first-of-its-kind mobile rebooking tool that empowers travelers to skip the line and instantly book a new ticket – on any airline at no additional cost – in the event of a flight cancellation, four-hour delay, or missed connection. Freebird provides travelers with instant notifications in the event of a flight disruption, and offersthe ability to rebook in less than 30 seconds with only three taps on their mobile device.
• Opendoor Technologies — Opendoor is the new way to sell your home. Skip the hassle of listing, showings and months of stress, and close on your own timeline. Get a free offer today!
• Steven.com — The operating system for the creator economy. Connecting creators to resources, platforms, community and technology where trust shifts to individuals.

Portfolio highlights

• Cenoa — Cenoa - The smartest way to get paid globally!
• Chainlink — Chainlink is the most widely used oracle network for powering hybrid smart contracts, enabling any blockchain to securely access off-chain data & computations.
• Hue — Hue is a software as a service platform that finds and incorporates real video evaluations into the marketing channels and websites of e-commerce companies.Hue enables businesses and retailers to incorporate TikTok-style shoppable films on their e-commerce websites, giving customers confidence to add to cart.

Portfolio highlights

• Hemi Labs — Hemi (https://hemi.xyz) is a modular protocol that integrates Bitcoin and Ethereum to amplify and extend the core capabilities of the two leading blockchain networks. This offers a novel perspective on blockchain interoperability and scaling by approaching Bitcoin and Ethereum as components of a single supernetwork. The result providessecurity that exceeds that of Bitcoin (“superfinality”) and new levels of blockchain programmability, portability, and potential. Hemi was co-founded by Jeff Garzik (former Bitcoin core developer) and Max Sanchez (inventor of the Proof-of-Proof consensus protocol), and is surrounded by a team of renowned blockchain engineers, strategic partners and investors.
• Prodigy.Fi — Prodigy.Fi is a decentralized platform dedicated to facilitating income generation through on-chain dual investment trading strategies.
• Rails — Experience unparalleled speed and efficiency with Rails, your go-to platform for lightning-fast crypto perpetuals trading.

Portfolio highlights

• On Re — Leading onchain asset manager | Powering Solana's highest-yielding institutional dollar asset backed by real-world reinsurance
• BetHog — BetHog is a new crypto sports book that brings home the bacon.
• Exponent Finance — Outperform market rates with Solana's leading yield exchange. Community: https://t.co/tROuLHqyfC

Portfolio highlights

• 3Commas — 3Commas develops a crypto-asset management tool for tracking investments and exchanges in a unified platform. It provides access to a unified dashboard as the central hub for trading and portfolio management execution.
• Fuel Labs — At Fuel, we are building the fastest execution layer for the modular blockchain stack.
• Optim Finance — Optim Finance provides investment tools that optimize yield on digital assets. Their financial primitives enable users to rent ADA delegation rights to power novel use cases such as SPO loans, leverage into ISOs, and initial bonds.

Portfolio highlights

• RISE Chain — RISE is a next-generation Ethereum Layer 2 blockchain designed to redefine blockchain performance by delivering near-instant transaction confirmations at unprecedented scale, all while upholding Ethereum’s foundational principle of decentralization
• Limitless Labs — Trade on future outcomes with Limitless, a prediction market for crypto prices, sports matches, politics, and major world events.
• BIO Protocol — Biotech's new financial layer.

Portfolio highlights

• XFX — Powering international settlement
• Cyclops.io — Cyclops is the only crypto and stablecoin platform exclusively for payments companies. Cyclops enables payment service providers to accept crypto, do stablecoin settlement, and manage digital assets with enterprise-grade security. We provide PSPs, Card Networks, Acquirers, PayFacs and otherws with compliant crypto solutions without building in-house. Cyclops is chain agnostic, supporting Bitcoin, Ethereum, USDC, USDT, and multi-chain stablecoin settlement. White-label and turnkey offerings.
• Birdai Labs — Birdai operates at the base of the chain, measures where value leaks between an order and its fill, and is built to return it to the people who create the order flow.

Portfolio highlights

• Cambrian — The financial intelligence layer for agents & institutions. Cambrian's API helps you make the best financial decisions onchain. Testnet waitlist @ https://t.co/eohvz17ALp
• Superpower — the economy layer where agents make money
• Cluster Protocol — Cluster Protocol is the co-ordination layer for AI agents, a carnot engine fueling the AI economy making sure the AI developers are monetized for their AI models and users get an unified seamless experience to build that next AI app/ agent within a virtual disposable environment facilitating the creation of modular, self-evolving AI agents.

Portfolio highlights

• RedotPay — Where Crypto Meets Real Life | Trusted by 8M+ | Accepted at 130M+ merchants | Pay with BTC, ETH, USDC, USDT & more
• Yellow Card — Yellow Card is a licensed stablecoin payments infrastructure provider powering global money movement across USD and 50+ local currencies. Talk to us.
• Fabric Cryptography — Building towards a trustless future with custom chips for advanced cryptography.

Portfolio highlights

• ETHGas — The Realtime primitive that accelerates Ethereum over 100x
• Burstverse — Burstverse, a Web3 AI business, is at the vanguard of the DeFai revolution, offering an AI-powered decentralized financial platform that allows users to automate and control their cryptocurrency operations using natural language. Burstverse is changing the way consumers engage with and benefit from decentralized financial ecosystems by mergingcutting-edge AI and DeFi flexibility.
• Limitless Labs — Trade on future outcomes with Limitless, a prediction market for crypto prices, sports matches, politics, and major world events.

Portfolio highlights

• Obita — Obita provides enterprise-grade borderless payment infrastructure for fiat and compliant stablecoins, supporting global collections, payouts, and treasury operations.
• Hemi Labs — Hemi (https://hemi.xyz) is a modular protocol that integrates Bitcoin and Ethereum to amplify and extend the core capabilities of the two leading blockchain networks. This offers a novel perspective on blockchain interoperability and scaling by approaching Bitcoin and Ethereum as components of a single supernetwork. The result providessecurity that exceeds that of Bitcoin (“superfinality”) and new levels of blockchain programmability, portability, and potential. Hemi was co-founded by Jeff Garzik (former Bitcoin core developer) and Max Sanchez (inventor of the Proof-of-Proof consensus protocol), and is surrounded by a team of renowned blockchain engineers, strategic partners and investors.
• Questflow — AI Finance Agent for Outsized Returns. An AI finance agent that lets you invest alongside top investors across markets.

Portfolio highlights

• TurboFlow — Trading, made simple. Everyone gets a seat at TurboFlow.
• DePay — DePay is an Argentina-based real-time payments infrastructure startup.
• Ceramic Network — We've joined @textileio to build the first open intelligence network for AI agents. Follow us there.

Portfolio highlights

• Entravel — Market leading hotel distribution API & room mapping. Agentic interface for AI agents. Turnkey hotel booking white labels for businesses.
• Solana — Solana is the high performance network powering internet capital markets, payments, and crypto applications. Fast. Decentralized. Scalable. Energy efficient. Solana can power thousands of transactions per second.
• TrueNorth — The first Agentic Brokerage - build your own professional trading desk

Portfolio highlights

• Hook — Hook provides an NFT-native options protocol that enables active traders to earn more with less. For active traders, options allow them to earn multiples of buying the floor for the best trades.
• Atlas — Atlas builds cutting-edge generative 3D AI technology to enable the creation of assets & virtual worlds.
• Particle — Particle: Diversified Restaking for Leverage Trading and Interest Rate Swap.

Portfolio highlights

• Redpill AI — Access 200+ AI models with privacy-first infrastructure. Private models in GPU TEE, OpenAI-compatible API, zero data retention.
• Rivet.cloud (Formerly OpenRelay) —
• Karmine Corp — Karmine Corp is an esports organization that offers merchandise and competes in games like league of legends, trackmania, and others.

Portfolio highlights

• Axis — Turning market inefficiencies into tokenized alpha. Backed by @galaxyhq, @FalconXGlobal, @okx.
• Zoo Finance — Zoo Finance is a pioneering DeFi protocol focused on unlocking liquidity from locked assets, empowering users to access capital more efficiently while maximizing the utility of their on-chain holdings.
• Hypernova — The onchain prop firm, built to back traders.

Portfolio highlights

• Predicate — Policy for blockchain applications
• BabylonChain — Babylon is a VC-backed blockchain project founded by Claude. E. Shannon Award recipient, Professor David Tse from Stanford University. The project’s mission is to bring Bitcoin’s unparalleled security to all PoS blockchains in the world. To this end, we are building, as the bridge between Bitcoin and the PoS world, a new public Cosmos-based PoSblockchain called Babylon with a native token.
• Reown — A complete crypto and stablecoin infrastructure solution built on the world's largest wallet network, built for apps, wallets, fintechs & institutions.

Portfolio highlights

• Entravel — Market leading hotel distribution API & room mapping. Agentic interface for AI agents. Turnkey hotel booking white labels for businesses.
• twyne — Twyne operates a decentralized finance (DeFi) credit delegation protocol that routes underutilized borrowing capacity from collateral depositors directly to active market borrowers. The infrastructure functions as an intermediary aggregation layer on top of established lending markets to optimize credit distribution and maximize capital efficiency.
• Bundle — Bundle is the first networked rewards platform in the world, revolutionizing how companies interact with and reward their clients.Bundle provides companies with access to significantly more incentives than they could provide on their own by pooling brand incentive funds into common reward pools. Even though they only contribute a small portion ofthe total incentive value, brands can increase conversions.

Portfolio highlights

• Kaizan — Kaizan is a Client Intelligence Platform for Client Success teams to retain and grow revenue
• Baanx Group — Replacing Banking With Technology - Our technology enables self-custody transactions, allowing users to buy, spend, and borrow directly against digital assets securely and effortlessly.
• Build on Bitcoin — BOB (Build on Bitcoin) is the first Bitcoin L2 with full EVM compatibility

Portfolio highlights

• Beldex — Beldex is a private ecosystem consisting of decentralized applications. The Beldex privacy coin (BDX) is a utility coin of the Beldex private ecosystem.
• Superset — The Unified Execution Layer for stablecoins, tokenized deposits, and onchain FX. One shared liquidity market, accessible across all chains.
• ZenChain — The first decentalised Bitcoin EVM L1 bringing smart contracts, composability, and true cross-chain liquidity to BTC.

Portfolio highlights

• InsideDesk — Reduce AR days, boost collections, and streamline billing operations with InsideDesk's centralized revenue cycle management platform.
• CWX — CLOUDWERX provides elite engineering resources to accelerate your business.
• Lightworks — Lightworks is a Canadian consulting company that focuses on enterprise AI infrastructure and control systems. The company works with the biggest and most regulated companies in the world to plan, manage, and safeguard AI-powered systems.

Portfolio highlights

• TBook — The first embedded RWA liquidity layer that brings institutional-grade tokenized yield into user-facing apps
• Catapult — Market agnostic, hyper-volatile charts. Ride 100x in minutes. https://t.co/kMSFE0RKBI
• Euclid Protocol — The Unified Liquidity Layer for DeFi | Euclid Protocol is a cross-chain DeFi infrastructure enabling efficient token swaps, liquidity aggregation, and optimized routing across 50+ blockchains on Evm, Cosmos and Solana.

Portfolio highlights

• AIsa — Powering AI Agents with one integration for premium APIs, data, compute, and payments. Backed by @AlibabaGroup @drapervc @Tribecap
• Databento — Databento provides real-time and historical market data APIs. Access data for equities, futures, options, and more with one integration. Sign up for $125 in free credits.
• Higgsfield — The ultimate AI-powered camera control for creators by creators

Portfolio highlights

• Cyphort — Cyphort has developed Next Generation Distributed Software Platform to provide the broadest enterprise visibility and accurate detection of advanced threats & evasion techniques, and zero-day attacks by utilizing behavioral analytics, machine learning, and Long-Data Security-Analytics.Cyphort's innovative approach detects the mostadvanced threats through a highly accurate platform combined with validation and prioritization of threats in context of the organizations eco-system. Through this process Cyphort produces highly customized Actionable Intelligence to users.The Cyphort Distributed Platform has been build with flexibility allowing for seamless integration and detection not only at the edge and network layers but also in virtual infrastructures, cloud environments, and mobile platforms.
• Metriport — Metriport helps digital health companies access and manage patient health and medical data, through an open-source and universal API.
• Digital Reef — Digital Reef, Inc. provides scalable and open platform for eDiscovery services and digital information governance applications. It helps meet the needs of corporate and law firm clients to significantly lower costs, mitigate risks, and reduce time associated with the handling and processing of high volumes of electronically stored information (ESI)in the wake of eDiscovery.

Portfolio highlights

• Levl — Levl's infrastructure makes stablecoin-powered payments accessible, compliant, and operationally seamless. Supporting USD, EUR, GBP Named Accounts and liqudity into emerging markets.
• Veera — Veera is an internet browser that gives you rewards every time you browse.
• OpenTrade — OpenTrade providers web3 treasurers, institutions, and accredited investors access to on-chain structured financial products backed by investment grade RWAs.

Portfolio highlights

• Bloom — Moved to @bloomsocial
• Lite Strategy — MEI Pharma, Inc. (Nasdaq: MEIP) is a San Diego-based oncology company focused on the clinical development of novel therapies for cancer. The Company’s clinical development pipeline includes lead drug candidate Pracinostat, a potential best-in-class, oral histone deacetylase (HDAC) inhibitor. Pracinostat has been tested in more than 150 patients inmultiple Phase I and exploratory Phase II clinical trials, including advanced hematologic malignancies such as myelodysplastic syndrome, acute myeloid leukemia and myelofibrosis. The Company expects to initiate a randomized Phase II trial of Pracinostat in combination with standard-of-care in at least one hematologic malignancy toward the middle of 2013. In addition, MEI Pharma is developing two drug candidates derived from its isoflavone-based technology platform, ME-143 and ME-344. Results from a Phase I trial of intravenous ME-143 in heavily treated patients with solid refractory tumors were presented at the American Society of Clinical Oncology Annual Meeting in June 2012. A Phase I clinical trial of intravenous ME-344 in patients with solid refractory tumors is ongoing.
• VersiFi — VersiFi is a prime services platform. It provides full-service prime brokerage solutions.

Portfolio highlights

• Blitzy — You Describe It, We Build It
• Satflow — Satflow aims to improve Bitcoin DEXs, enhance decentralization, and address issues like lack of advanced order types, high-speed data, and liquidity pools.
• Build on Bitcoin — BOB (Build on Bitcoin) is the first Bitcoin L2 with full EVM compatibility

Portfolio highlights

• CAEX — CAEX is a crypto asset exchange operator. CAEX builds transparent and secure crypto asset trading platform for investors.
• Coinone — Coinone is the cryptocurrency exchanges. Under the vision to ‘Bring Blockchain into the World,’ they aspires to lead the new world of finance through blockchain technology. They currently operates the third largest exchange. They prioritizes the protection of clients’ assets and is dedicated to providing the most secure investing environment.
• townsquare — Crosschain RWA yield infrastructure powering stock tokens, RWAs & institutional strategies | https://t.co/5glAR6k007

Portfolio highlights

• Almanak — Almanak is a decentralized finance (DeFi) smart agent platform that harnesses the power of artificial intelligence to automate, optimize, and intelligently manage a wide range of DeFi investment strategies. It enables users to create and deploy automated DeFi trading and risk-management strategies through coordinated AI agents. It provides anenvironment where AI handles strategy coding, backtesting across thousands of Monte Carlo simulations, optimization, risk monitoring, deployment via non-custodial Safe-based multisig accounts, and real-time performance monitoring with alerting capabilities. The platform supports seamless interaction with multiple blockchains and protocols via an LLM-powered interface.Almanak targets active DeFi participants, developers building financial applications, investment professionals, and users seeking automated portfolio insights. It emphasizes enhanced automation, continuous strategy execution, and adaptive automation driven by emerging AI techniques to respond to evolving market conditions.
• Megapot — Megapot is a decentralized peer-to-peer protocol that connects liquidity providers, apps, and gamers, allowing anyone to effortlessly sell tickets while also using them for retention and monetization purposes, allowing customers to earn huge yields.
• Tenbin Labs — TradFi liquidity with DeFi utility. Global markets, tokenized on-chain.

Portfolio highlights

• Derivio — Be early. Trade smarter. One terminal.
• Othentic — Othentic provides builders with the most intuitive way to spin up a modular blockchain on top of EigenLayer
• Mitosis — Mitosis is an EOL L1 blockchain that redefines the DeFi LP experience. EOL implements economies of scale to asset management and empowers LPs with increased bargaining power.

Portfolio highlights

• tanX.fi — Reliable, self custodial and high performance liquidity network for traders, institutions and exchanges.
• Brine.fi — The best onchain spot trading crypto exchange
• Payman AI, Inc — We deploy AI that executes real banking transactions - payments, transfers, account analysis - through voice or text, on your existing rails. Full visibility, configurable controls, complete audit trails.

Portfolio highlights

• Solana — Solana is the high performance network powering internet capital markets, payments, and crypto applications. Fast. Decentralized. Scalable. Energy efficient. Solana can power thousands of transactions per second.
• Centrifuge — Centrifuge is the platform for tokenized real-world assets, providing the infrastructure and ecosystem to tokenize, manage, and invest into RWAs.
• Hivemapper — Explore the Hivemapper Network's global coverage.

Portfolio highlights

• MetWare — Maiwei Metabolism is a developer of novel medical metabolic technology, specializing in the use of cutting-edge metabolomics technology in the domains of life science research and medicine.
• Zulu Network — Zulu Network is the first DePin-focused Bitcoin Layer 2 to achieve the tokenization of computing power, allowing anyone to power DePIN innovation and earn Bitcoin.

Portfolio highlights

• Nibiru Chain — Nibiru is a smart contract ecosystem with a high-performance, EVM-equivalent execution layer. Nibiru is engineered to meet the growing demand for versatile, scalable, and easy-to-use Web3 applications.
• Moso — Get started today! Shop online and earn crypto at 2,000+ stores.
• Mystiko.Network — Mystiko.Network enables users to trade on private DEX just like on Uniswap while users' financial privacy is protected. Users could transfer assets to a brand new secret and ultra-safe address with full privacy. Any wallet could provide its user's such features by implementing Mystiko Wallet SDK.

Portfolio highlights

• Keplr — Introducing the first, and leading, IBC-enabled wallet for Cosmos and beyond
• Reppo Labs — Blockchain Network that connect Data Owners with AI Developers and AI agents through Programmable IP Co-ownership
• Prodia — Prodia is a multimedia design software and developer of artificial intelligence that creates APIs and images.