Top 50 Cryptocurrency Startup Investors in Cayman Islands (September 2026)

Portfolio highlights

• Deblock — Better than your bank: IBAN, Visa card, instant SEPA transfers, 4% a year, and a self-custody wallet for your crypto.
• Harbor — Future Proof Finance
• Dakota Ridge — Stablecoin infrastructure that enables global money movement.

Portfolio highlights

• Hook — Hook provides an NFT-native options protocol that enables active traders to earn more with less. For active traders, options allow them to earn multiples of buying the floor for the best trades.
• Atlas — Atlas builds cutting-edge generative 3D AI technology to enable the creation of assets & virtual worlds.
• Particle — Particle: Diversified Restaking for Leverage Trading and Interest Rate Swap.

Portfolio highlights

• AIsa — Powering AI Agents with one integration for premium APIs, data, compute, and payments. Backed by @AlibabaGroup @drapervc @Tribecap
• Databento — Databento provides real-time and historical market data APIs. Access data for equities, futures, options, and more with one integration. Sign up for $125 in free credits.
• Higgsfield — The ultimate AI-powered camera control for creators by creators

Portfolio highlights

• Freebird — Freebird is a first-of-its-kind mobile rebooking tool that empowers travelers to skip the line and instantly book a new ticket – on any airline at no additional cost – in the event of a flight cancellation, four-hour delay, or missed connection. Freebird provides travelers with instant notifications in the event of a flight disruption, and offersthe ability to rebook in less than 30 seconds with only three taps on their mobile device.
• Opendoor Technologies — Opendoor is the new way to sell your home. Skip the hassle of listing, showings and months of stress, and close on your own timeline. Get a free offer today!
• Steven.com — The operating system for the creator economy. Connecting creators to resources, platforms, community and technology where trust shifts to individuals.

Portfolio highlights

• Hemi Labs — Hemi (https://hemi.xyz) is a modular protocol that integrates Bitcoin and Ethereum to amplify and extend the core capabilities of the two leading blockchain networks. This offers a novel perspective on blockchain interoperability and scaling by approaching Bitcoin and Ethereum as components of a single supernetwork. The result providessecurity that exceeds that of Bitcoin (“superfinality”) and new levels of blockchain programmability, portability, and potential. Hemi was co-founded by Jeff Garzik (former Bitcoin core developer) and Max Sanchez (inventor of the Proof-of-Proof consensus protocol), and is surrounded by a team of renowned blockchain engineers, strategic partners and investors.
• Prodigy.Fi — Prodigy.Fi is a decentralized platform dedicated to facilitating income generation through on-chain dual investment trading strategies.
• Rails — Experience unparalleled speed and efficiency with Rails, your go-to platform for lightning-fast crypto perpetuals trading.

Portfolio highlights

• BULK Trade — One Exchange Infinite Markets
• Pave Bank — The world's first multi-asset and programmable bank
• Nova Markets — The next billion-dollar market starts here. Powered by @HyperliquidX

Portfolio highlights

• Bloom — Moved to @bloomsocial
• Lite Strategy — MEI Pharma, Inc. (Nasdaq: MEIP) is a San Diego-based oncology company focused on the clinical development of novel therapies for cancer. The Company’s clinical development pipeline includes lead drug candidate Pracinostat, a potential best-in-class, oral histone deacetylase (HDAC) inhibitor. Pracinostat has been tested in more than 150 patients inmultiple Phase I and exploratory Phase II clinical trials, including advanced hematologic malignancies such as myelodysplastic syndrome, acute myeloid leukemia and myelofibrosis. The Company expects to initiate a randomized Phase II trial of Pracinostat in combination with standard-of-care in at least one hematologic malignancy toward the middle of 2013. In addition, MEI Pharma is developing two drug candidates derived from its isoflavone-based technology platform, ME-143 and ME-344. Results from a Phase I trial of intravenous ME-143 in heavily treated patients with solid refractory tumors were presented at the American Society of Clinical Oncology Annual Meeting in June 2012. A Phase I clinical trial of intravenous ME-344 in patients with solid refractory tumors is ongoing.
• VersiFi — VersiFi is a prime services platform. It provides full-service prime brokerage solutions.

Portfolio highlights

• Cyphort — Cyphort has developed Next Generation Distributed Software Platform to provide the broadest enterprise visibility and accurate detection of advanced threats & evasion techniques, and zero-day attacks by utilizing behavioral analytics, machine learning, and Long-Data Security-Analytics.Cyphort's innovative approach detects the mostadvanced threats through a highly accurate platform combined with validation and prioritization of threats in context of the organizations eco-system. Through this process Cyphort produces highly customized Actionable Intelligence to users.The Cyphort Distributed Platform has been build with flexibility allowing for seamless integration and detection not only at the edge and network layers but also in virtual infrastructures, cloud environments, and mobile platforms.
• Metriport — Metriport helps digital health companies access and manage patient health and medical data, through an open-source and universal API.
• Digital Reef — Digital Reef, Inc. provides scalable and open platform for eDiscovery services and digital information governance applications. It helps meet the needs of corporate and law firm clients to significantly lower costs, mitigate risks, and reduce time associated with the handling and processing of high volumes of electronically stored information (ESI)in the wake of eDiscovery.

Portfolio highlights

• Morpho Labs — Morpho is an open credit network that connects lenders and borrowers to the best possible opportunities worldwide.
• Velocity — Velocity provides a unified platform for efficiently moving and managing funds across both traditional banks and blockchains.
• Silicon Data — Revolutionize compute markets through unparalleled data transparency, financial product innovation and market intelligence

Portfolio highlights

• X10 — X10 operates as a hybrid crypto exchange provider.
• Trace Finance — Trace Finance enables secure and swift connections between businesses and their customers through payments and automatic transaction reconciliations on a large scale, promoting integrity and efficiency.
• Ceramic Network — We've joined @textileio to build the first open intelligence network for AI agents. Follow us there.

Portfolio highlights

• InsideDesk — Reduce AR days, boost collections, and streamline billing operations with InsideDesk's centralized revenue cycle management platform.
• CWX — CLOUDWERX provides elite engineering resources to accelerate your business.
• Lightworks — Lightworks is a Canadian consulting company that focuses on enterprise AI infrastructure and control systems. The company works with the biggest and most regulated companies in the world to plan, manage, and safeguard AI-powered systems.

Portfolio highlights

• Pally — Pally is an AI Agent for your network.
• twyne — Twyne operates a decentralized finance (DeFi) credit delegation protocol that routes underutilized borrowing capacity from collateral depositors directly to active market borrowers. The infrastructure functions as an intermediary aggregation layer on top of established lending markets to optimize credit distribution and maximize capital efficiency.
• TrueNorth — The first Agentic Brokerage - build your own professional trading desk

Portfolio highlights

• EarnOS — EarnOS is the fully remote company that provides Global Ad & Payments Platform powered by Web3.
• KOR Protocol — KOR Protocol is a decentralized intellectual property (IP) infrastructure designed to empower creators, protect rights, and enable seamless collaboration and monetization of IP assets across various industries, including music, film, TV, gaming, and art. Backed by notable entities like Animoca Brands, Republic, Niantic, Sfermion, Solana, andprominent creators such as Black Mirror, Disclosure, deadmau5, and Richie Hawtin, KOR leverages blockchain, AI, and DeFi to offer a transparent, efficient, and scalable environment for IP expansion.
• Freehand — AI Teams for Complex Spend Management

Portfolio highlights

• TBook — The first embedded RWA liquidity layer that brings institutional-grade tokenized yield into user-facing apps
• Catapult — Market agnostic, hyper-volatile charts. Ride 100x in minutes. https://t.co/kMSFE0RKBI
• Euclid Protocol — The Unified Liquidity Layer for DeFi | Euclid Protocol is a cross-chain DeFi infrastructure enabling efficient token swaps, liquidity aggregation, and optimized routing across 50+ blockchains on Evm, Cosmos and Solana.

Portfolio highlights

• Redpill AI — Access 200+ AI models with privacy-first infrastructure. Private models in GPU TEE, OpenAI-compatible API, zero data retention.
• Rivet.cloud (Formerly OpenRelay) —
• Karmine Corp — Karmine Corp is an esports organization that offers merchandise and competes in games like league of legends, trackmania, and others.

Portfolio highlights

• Levl — Levl's infrastructure makes stablecoin-powered payments accessible, compliant, and operationally seamless. Supporting USD, EUR, GBP Named Accounts and liqudity into emerging markets.
• Veera — Veera is an internet browser that gives you rewards every time you browse.
• OpenTrade — OpenTrade providers web3 treasurers, institutions, and accredited investors access to on-chain structured financial products backed by investment grade RWAs.

Portfolio highlights

• BiHelix — BiHelix is a bitcoin native infrastructure that offers user-friendly and scalable application framework for the Bitcoin ecosystem, allows users to build any type of DApp on bitcoin.
• Yala — Yala operates a multi-token system and unlocks a thriving and interconnected DeFi ecosystem on Bitcoin​.
• Bool Network — Bool Network is a permissionless, decentralized, and secure Bitcoin verification layer that intends to securely decentralize the Bitcoin network's expansion while maintaining Bitcoin's consensus, ultimately increasing wealth within the Bitcoin ecosystem.

Portfolio highlights

• NexGami — NexGami is a gamefi platform that empowers the next generation of players by reshaping the gaming landscape.
• Coinpanion — Dive into the world of crypto, NFT, DeFi and metaverse with Coinpanion's smart portfolios.
• Zulu Network — Zulu Network is the first DePin-focused Bitcoin Layer 2 to achieve the tokenization of computing power, allowing anyone to power DePIN innovation and earn Bitcoin.

Portfolio highlights

• Commonware — Commonware is a startup that supplies developers with a "anti-framework" — effectively all of the building pieces for developing a blockchain — in order to go beyond the era of standardized, general-purpose software kits.
• Keplr — Introducing the first, and leading, IBC-enabled wallet for Cosmos and beyond
• Optimum — Optimum constitutes a decentralized, high-performance memory infrastructure tailored for use across various blockchains.

Portfolio highlights

• OneBalance — OneBalance is a new framework for credible accounts - combining chain abstraction, gas abstraction and permission management to solve the fragmented Web3 user experience.
• Octane — A developer-first platform to stress-test your smart contracts with cutting-edge AI. One-click install. Save time and money on security.
• Across Protocol — Across Protocol is a blockchain transaction chain provider.

Portfolio highlights

• kpk — Market leaders in onchain asset management, karpatkey helps crypto organisations grow their assets responsibly and sustainably. We provide active treasury management, financial services, ecosystem growth and risk management solutions.
• OneBalance — OneBalance is a new framework for credible accounts - combining chain abstraction, gas abstraction and permission management to solve the fragmented Web3 user experience.
• ETHZilla — Born from Ethereum. Built for everyone

Portfolio highlights

• Zulu Network — Zulu Network is the first DePin-focused Bitcoin Layer 2 to achieve the tokenization of computing power, allowing anyone to power DePIN innovation and earn Bitcoin.

Portfolio highlights

• Neutrl — Neutrl partners with online brands to provide a sustainable shopping experience - allow customers to remove carbon emissions from their orders.
• Optimum — Optimum constitutes a decentralized, high-performance memory infrastructure tailored for use across various blockchains.
• Hyperdrive — Hyperdrive delivers investment growth strategies utilizing a portfolio-centered approach.

Portfolio highlights

• Curvance — Curvance is a crosschain lending market for yield-bearing assets and any other ERC-20 tokens on Ethereum, Polygon zkEVM, Base, Arbitrum, and Optimism and aspires to establish itself as the de-facto money market for any ERC-20 token.
• Darkbright Studios — Darkbright Studios is the developer of Smolbound, a Web3 life sim RPG.
• Fabric Cryptography — Fabric develops a custom cryptography hardware to accelerate cryptography algorithms. The chips, whose components exclusively serve cryptographic purposes, are based on Verifiable Processing Units (VPUs) which incorporate features of GPUs and ASICs to improve the speed and cost of advanced cryptographic workloads.

Portfolio highlights

• OneBalance — OneBalance is a new framework for credible accounts - combining chain abstraction, gas abstraction and permission management to solve the fragmented Web3 user experience.

Portfolio highlights

• Predicate — Predicate network simplifies transaction prerequisites.
• BabylonChain — Babylon is a VC-backed blockchain project founded by Claude. E. Shannon Award recipient, Professor David Tse from Stanford University. The project’s mission is to bring Bitcoin’s unparalleled security to all PoS blockchains in the world. To this end, we are building, as the bridge between Bitcoin and the PoS world, a new public Cosmos-based PoSblockchain called Babylon with a native token.
• Reown — A complete, compliant payment method built on the world's largest wallet network, designed to fit directly into existing PSP stacks with a single, future-ready integration.

Portfolio highlights

• Derivio —
• Mitosis — Mitosis is an EOL L1 blockchain that redefines the DeFi LP experience. EOL implements economies of scale to asset management and empowers LPs with increased bargaining power.
• Obol Labs — Powering and securing the multi-trillion dollar Ethereum economy w/ Distributed Validators - the end game of Ethereum staking.

Portfolio highlights

• Num Finance — Num Network offers businesses a fast and efficient way to scale operations in emerging markets with yield, loans and digital assets through our ramps and local stablecoins, via platform or API.Stay ahead of the competition with the money tools of the future. Our cutting-edge technology is powered by web 3, providing fast and secure access tofinancial services.
• Redeem — Redeem uses Web3 technology to enable users to send and redeem non-fungible tokens (NFT) by using their phone numbers.
• Brassica — Purpose-built APIs to navigate the alternative asset investment landscape without the burden of dealing with multiple vendors.

Portfolio highlights

• Gamium — Gamium is a Web3 and Metaverse technology company building the truly Decentralized Social Metaverse.
• 0G — The First Decentralized AI Operating System
• Mind Network — The 1st Fully Homomorphic Encryption (FHE) Restaking Layer for AI and POS Networks. Mind Network is backed by Binance Labs, Hashkey, Big Brain, Chainlink, etc.

Portfolio highlights

• OneBalance — OneBalance is a new framework for credible accounts - combining chain abstraction, gas abstraction and permission management to solve the fragmented Web3 user experience.
• Hyperdrive — Hyperdrive delivers investment growth strategies utilizing a portfolio-centered approach.

Portfolio highlights

• PrimeDAO — PrimeDAO is an open finance system based on programmable money that is being realized on Ethereum. The company develops tools that transform Defi into a collaborative ecosystem.
• Creator.Bid — Hub for the AI Creator Economy
• Treasure — Treasure is building a gaming and entertainment powerhouse, built and owned by all.

Portfolio highlights

• OneBalance — OneBalance is a new framework for credible accounts - combining chain abstraction, gas abstraction and permission management to solve the fragmented Web3 user experience.

Portfolio highlights

• OneBalance — OneBalance is a new framework for credible accounts - combining chain abstraction, gas abstraction and permission management to solve the fragmented Web3 user experience.

Portfolio highlights

• Nibiru Chain — Nibiru is a smart contract ecosystem with a high-performance, EVM-equivalent execution layer. Nibiru is engineered to meet the growing demand for versatile, scalable, and easy-to-use Web3 applications.
• Sleek — Sleek is a FREE browser extension that offers seamless checkout from every store on the internet AND gives you up to 25% cash back when shopping online.
• Slingshot AI — Slingshot AI is a mental health research lab building a foundation model for psychology. Our mission is to use AI to make mental health care more accessible, and to help people change their minds and lives the way they want to.

Portfolio highlights

• Setscale — Setscale simplifies trade & empower companies to scale with Purchase Order Financing. Setscale only get paid once you do! We fund Supply. You meet demand.
• Figure — Figure is the first-of-its-kind AI robotics company bringing a general purpose humanoid to life.
• Clara — Clara is an end-to-end corporate spend management solution for growing businesses in Latin America. Clara's credit cards and spend management solution are already being used by thousands of top companies in Mexico, Brazil, and Colombia.The company is backed by leading regional and global investors, such as Coatue, DST Global, monashees,Kaszek, Canary, Picus Capital, Avid Ventures, A*, Box Group, SOMA Capital, SV Angel, and dozens of angel investors including some of the most successful founders in LatAm and the world. Clara reached a unicorn valuation in record time and has been recognized as a Great Place to Work and a LinkedIn Top Startup.Clara is creating the future of how company finances are run and helping our customers be more successful. Clara aspires to empower companies to operate with agility and financial clarity, ultimately increasing the economic competitiveness of Latin America.

Portfolio highlights

• Obita — Obita is a B2B financial network that offers stablecoin-driven transactions for enterprises, merchants, and fintechs.
• Inversion — Inversion is a technology-first investment company that acquires and transforms legacy businesses with blockchain technology.
• Heritage Distilling — Heritage Distilling Co. (HDC) is a craft distillery based in Gig Harbor, Washington. HDC is the most awarded craft distillery in North America by the American Distilling Institute 10 years in a row. We pour a little of our heart into every batch of spirits we make.

Portfolio highlights

• fomo — Fomo is a cutting-edge fintech startup revolutionizing the financial landscape through innovative technology and strategic partnerships.
• OneBalance — OneBalance is a new framework for credible accounts - combining chain abstraction, gas abstraction and permission management to solve the fragmented Web3 user experience.
• Trendies — Trendies is a provider of the Base Ecosystem Token Launch Platform, which is primarily designed for token holders.

Portfolio highlights

• MetWare — Maiwei Metabolism is a developer of novel medical metabolic technology, specializing in the use of cutting-edge metabolomics technology in the domains of life science research and medicine.
• Zulu Network — Zulu Network is the first DePin-focused Bitcoin Layer 2 to achieve the tokenization of computing power, allowing anyone to power DePIN innovation and earn Bitcoin.

Portfolio highlights

• Nibiru Chain — Nibiru is a smart contract ecosystem with a high-performance, EVM-equivalent execution layer. Nibiru is engineered to meet the growing demand for versatile, scalable, and easy-to-use Web3 applications.
• iCopious.com — iCopius.com offers Silent Access, a pre-paid, anonymous CD-ROM-based internet product.
• MobileEngines — MobileEngines is the leading provider of mobile entertainment services that help drive adoption of the new mobile world. MobileEngines partners with wireless carriers and mobile portals worldwide to distribute mobile specific services targeted at Gen X and Y end users.

Portfolio highlights

• P2P Validator — P2P Validator helps investors compound their cryptocurrency investments by participating in staking. We offer highly available & secure, non-custodial staking services.

Portfolio highlights

• Ion Protocol — Ion is an Open Source Protocol built to support Ethereum stakers and restakers, to unlock a world of new applications for their assets.
• Baselayer — Baselayer automates business risk assessment and eliminates B2B fraud in the financial sector. It offers services such as business verification (KYB), fraud detection, business onboarding optimization, risk profiling, portfolio monitoring & alerting, and workflow automation. Baselayer empowers 100s of financial institutions, governmentagencies, lenders, and fintech to unlock instant trust with any business in America.
• Blueprint Finance — Blueprint Finance develops protocols and infrastructure to advance on-chain financing.

Portfolio highlights

• Neion Bio — Neion Bio uses advances in stem cell biology and genetic engineering to completely reimagine the biopharmaceutical production process.
• Orbital — Orbital is a startup that is creating artificial intelligence data centers for deployment in low-Earth orbit to circumvent terrestrial power and cooling limits. The company specializes in satellite-based compute for AI inference workloads, utilizing continuous solar power and space's inherent radiative cooling.
• Synthetic — Synthetic provides an autonomous accounting agent that processes financial data and produces completed monthly books with minimal manual input. Its system handles tasks such as transaction categorization, reconciliation, and financial record generation. The platform is designed to integrate with existing financial tools and maintain structured,auditable outputs.

Portfolio highlights

• ZATAP — Explore how ZATAP connects industries with real-time engagement and loyalty through innovative technology.
• Matter Labs — Matter Labs is scaling Ethereum with zero-knowledge proofs to accelerate public blockchain adoption. The company started out of scientific curiosity, the joy of engineering, and a deep conviction, the most impactful way to improve the world today is to provide an open and free alternative to its existing, deeply flawed financial system.Thecompany was founded in 2018 with its head office in Berlin, Germany.
• Young Platform — Il crypto exchange italiano dove puoi acquistare e vendere Bitcoin e le migliori altcoin del mercato. Accumula criptovalute e costruisci il tuo futuro finanziario giorno dopo giorno.

Portfolio highlights

• Pixelverse — Pixelverse is a blockchain-based, pixelated P2E game.
• Mavryk Dynamics — Mavryk Dynamics simplifies trading real-world assets (RWA) and using decentralized finance (DeFi).
• Swarm Network — Swarm Network is a decentralized network for owning, controlling, and monetizing AI agents.

Portfolio highlights

• OP3N — Founded in 2021 as a subsidiary of EST Media Holdings, OP3N is the global Web3 superapp that serves as a one-stop-shop for all communication, connection and commerce with on-chain interactions in a simple unified interface. With a mission to create a more frictionless, decentralized and democratized creator economy on a global scale, OP3Nconsolidates the tools needed to mint, share and engage with digital goods and digital tokens into one vertical stack. OP3N’s leadership team leverages its cross-industry expertise from the entertainment, gaming and tech ecosystems, to lay the foundations for a new era of community-driven, inclusive entertainment while bringing everyone together on a journey into Web3. OP3N is co-led by media executive, artist, and serial entrepreneur Jaeson Ma, who has a successful track record launching companies including EST Studios, Stampede Ventures, East West Ventures, and 88rising, and who’s raised capital and advised on transactions totaling over $1 billion; and Eric Tu, an award-winning development executive who’s worked with major brands including Nike, Beats by Dre and Google, and as an Executive Producer with Bjork, Radiohead, Kendrick Lamar and more. The company is headquartered in Los Angeles. For more information, please visit: https://op3n.world.OP3N’s portfolio of projects includes a partnership with Tokyo fashion label AMBUSH; an intergalactic children’s book from Grimes; a partnership with entertainment icon Simon Fuller to produce an innovative musical film with the global pop group Now United; and the “Maybe You’re the Problem” music video from the singer-songwriter Ava Max, directed by the celebrated music video director Joseph Kahn.
• Juno — On-ramp to more than 20 chains with no holding period on crypto withdrawals
• Parallax — Receive money as if you were abroad. Save big with best rates and lowest fees. Withdraw instantly.

Portfolio highlights

• AfterHour — Join the best stock trading community with over $200M+ in verified positions from retail traders. Get trade signals, due diligence, and real-time alpha.
• Astrocade — Create, share, and play casual games with friends. No coding, no downloads. Just make something that millions of people can play.
• Atlas Invest — Commercial real estate bridge loans up to $20M with same-day term sheets and funding in as few as 7 days. Institutional private credit for investors.

Portfolio highlights

• PeakAI — AI-powered crypto distribution OS. From TikTok to everywhere. Peekaboo early signals. Spark micro-intel. Turn attention into capital.
• Slinky Network — Slinky Network provides an on-chain marketplace and payment protocol that connects AI agents and applications with third-party APIs. The company offers the SlinkyLayer platform, which wraps developer endpoints as discoverable skills and exposes them through an x402 pay-per-execution interface. Each API call triggers a non-custodial on-chainmicropayment, settling in the same request loop using networks such as Base and BNB Chain. Developers set prices, earn a defined revenue share, and receive instant payouts to their wallets without subscriptions or custodial holds. AI agents authenticate via wallet signatures, enabling autonomous, machine-to-machine access and payment without traditional logins or credit cards. The platform also records call ratings on-chain to provide portable, verifiable reputation for services.
• Fortune Protocol — Fortune Protocol brings the age- old tradition of fortune cookies to the modern prediction market.

Portfolio highlights

• Entravel — Market leading hotel distribution API & room mapping. Agentic interface for AI agents. Turnkey hotel booking white labels for businesses.
• Solana — Solana is the high performance network powering internet capital markets, payments, and crypto applications. Fast. Decentralized. Scalable. Energy efficient. Solana can power thousands of transactions per second.
• TrueNorth — The first Agentic Brokerage - build your own professional trading desk

Portfolio highlights

• Dzone Finance — Dzone finance is a cross-chain Dex/Bridge aggregator and build with new technology. Dzone is faster bridge and cheapest
• Harmonic — Harmonic is a block building system to increase validator rewards.
• Global Token Exchange — Global Token Exchange is an end-to-end decentralized trading platform with CEX-level performance.

Portfolio highlights

• Artela — Artela is an extensible L1 blockchain with parallel execution and modular VMs. With key innovation of EVM++, Artela enables modular, customizable, and scalable dApps.
• Diva — Diva Staking is an Ethereum Liquid Staking protocol powered by distributed validators and a set of permissionless node operators. Join our community and become part of Diva.
• CEBG Studio — CEBG Studio is a gaming studio.