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First Star Ventures, VC Fund

First Star Ventures

VC Fund

Boston, United States

First Star Ventures is a VC fund in Boston focused on Software and Artificial Intelligence. First Star partners with entrepreneurs solving real-world problems using data and machine learning, focusing on applications of frontier technologies such as AI, computational biotech, connected sensors, AR/VR, and blockchain. We believe in investing with conviction in visionary, technical founders inventing the future. Drawing on ourexperience and network of strategic partners across industries and regions, we help startups think big and grow fast.

Total investments:
64
Last investment:
Lead investor:
13%

Last updated:

Industries First Star Ventures invests in

SoftwareArtificial IntelligenceBiotechnologySaaSAnalytics

Stages First Star Ventures invests in

SeedPre-SeedSeries AFunding RoundSeries B

Countries First Star Ventures invests in

United StatesCanadaIsrael

Round sizes

Seed $1M–$7MPre-Seed $575k–$1.8MSeries A $4.2M–$15M

Contacts

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Round size

Seed
$1M–$7M
Pre-Seed
$575k–$1.8M
Series A
$4.2M–$15M

Investment Focus

Industry

  • Software 13 (20%)
  • Artificial Intelligence 8 (13%)
  • Biotechnology 7 (11%)
  • SaaS 6 (9%)
  • Analytics 6 (9%)
See all 91 industries →

Stage

  • Seed 35 (55%)
  • Pre-Seed 9 (14%)
  • Series A 8 (13%)
  • Funding Round 4 (6%)
  • Series B 1 (2%)
See all 6 stages →

Country

  • United States 35 (55%)
  • Canada 4 (6%)
  • Israel 2 (3%)

Team

NameTitleInvestmentsLinksEmail
Drew Volpe
Drew Volpe Partner, Co-Founder
Partner, Co-Founder Total investments: 33
Find email
Millie Liu
Millie Liu Co-Founder, Partner
Co-Founder, Partner Total investments: 2
Find email

Investments

CompanyDescriptionRoundLinks
Extellis Extellis
Extellis is a satellite imaging company focused on delivering reliable Earth observation data at an industrial scale with affordable and high-volume capacity. which allows satellites to capture real-time images in all weather conditions, 24/7. This technology enables Extellis to offer high-capacity satellite imaging that can monitor changesanywhere on Earth as they happen, overcoming limitations of current satellites that cannot take enough images daily for continuous monitoring. $6.8M / Seed / Nov 10, 2025
iOrganBio iOrganBio
iOrganBio is a pioneering cell production platform that uses CellForge to facilitate the intelligent manufacturing of human cells and organoids. $2M / Seed / Oct 29, 2025
Bedrock Energy Bedrock Energy
Bedrock Energy is developing drilling technology and advanced subsurface simulation software to enable geothermal heating and cooling. The company develops autonomous drilling technology and advanced subsurface simulation software to make geothermal heating and cooling more widespread, affordable, and accessible. $12M / Series A / Jan 22, 2025
Phaseshift Technologies Phaseshift Technologies
PhaseShift Technologies is addressing the critical need for new materials that can overcome limitations in performance, efficiency, cost, availability, and sustainability. Traditional material development relies heavily on trial-and-error, requiring costly and time-consuming physical experiments. This approach can extend projects over 10-20 yearsand cost millions of dollars, with no guarantee of success.PhaseShift's Rapid Alloy Design (RAD)™ technology revolutionizes this process by using AI to create optimized alloys tailored to specific use cases. Paired with Multi-Scale Simulations to accurately predict material performance, RAD™ minimizes the time and effort spent on unsuccessful trials. This leads to faster, more efficient development cycles and a significant reduction in resources required to meet design goals.Through the RAD™ platform, PhaseShift designs a portfolio of innovative alloys, which are commercialized via strategic partnerships with manufacturers. $3M / Seed / Oct 21, 2024
Phaseshift Technologies Phaseshift Technologies
PhaseShift Technologies is addressing the critical need for new materials that can overcome limitations in performance, efficiency, cost, availability, and sustainability. Traditional material development relies heavily on trial-and-error, requiring costly and time-consuming physical experiments. This approach can extend projects over 10-20 yearsand cost millions of dollars, with no guarantee of success.PhaseShift's Rapid Alloy Design (RAD)™ technology revolutionizes this process by using AI to create optimized alloys tailored to specific use cases. Paired with Multi-Scale Simulations to accurately predict material performance, RAD™ minimizes the time and effort spent on unsuccessful trials. This leads to faster, more efficient development cycles and a significant reduction in resources required to meet design goals.Through the RAD™ platform, PhaseShift designs a portfolio of innovative alloys, which are commercialized via strategic partnerships with manufacturers. $3M / Seed / Oct 21, 2024
Throne Throne
Throne is a health company that focuses on individual gut wellness and hydration maintenance. $1.2M / Seed / Oct 20, 2024
Bot Auto Bot Auto
Bot Auto develops and operates autonomous trucks for middle-mile freight. $20M / Seed / Sep 26, 2024
Enzymit Enzymit
Enzymit is creating a new transformation layer for manufacturing by combining computational enzyme design, deep learning, and a proprietary high-throughput discovery platform. We develop novel enzymatic pathways and run them in controllable cell-free production systems. This approach merges the selectivity of biology with the precision ofchemistry, enabling cleaner and more efficient production. Our platform has been validated with pharmaceutical-grade hyaluronic acid (HA), produced at kilogram scale with superior consistency and purity compared to fermentation. We are now advancing toward commercial HA supply while expanding the platform to products like heparin and human milk oligosaccharides (HMOs). $10M / Series A / Sep 25, 2024
Zanskar Zanskar
Zanskar develops a predictive platform informed by massive data for discovering previously unknown geothermal resources. Its platform includes subsurface characterization technology and massive data sets, enhancing and reducing risk in the exploration of geothermal resources. $30M / Series B / May 06, 2024
Bedrock Energy Bedrock Energy
Bedrock Energy is developing drilling technology and advanced subsurface simulation software to enable geothermal heating and cooling. The company develops autonomous drilling technology and advanced subsurface simulation software to make geothermal heating and cooling more widespread, affordable, and accessible. $8.5M / Seed / Oct 11, 2023
See all 64 investments →

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FAQ

What does First Star Ventures invest in?

First Star Ventures invests primarily in Software, Artificial Intelligence and Biotechnology startups, most often at Seed and Pre-Seed stage. Most of the 64 investments tracked by Shizune back companies in United States. The Investment Focus section breaks down every industry, stage and country in the portfolio.

What is First Star Ventures's check size?

First Star Ventures typically joins rounds of $1M–$7M at Seed, $575k–$1.8M at Pre-Seed and $4.2M–$15M at Series A. These ranges are 10th–90th percentile round sizes calculated from confirmed public funding rounds, so they are a realistic guide to the rounds First Star Ventures participates in.

How do I contact First Star Ventures?

Public channels for First Star Ventures include LinkedIn, X (Twitter) and the website linked on this profile. For a verified work email and phone number, create a free Shizune account — contact data is searched across 20+ sources and validated before delivery, so your outreach lands in the right inbox.

Who are the partners at First Star Ventures?

The team at First Star Ventures includes Drew Volpe (Partner, Co-Founder) and Millie Liu (Co-Founder, Partner). The Team section lists each member with their title, investment count and links.

Is Shizune's investor data accurate?

Yes — every stat on this profile is calculated from confirmed public funding rounds monitored across hundreds of sources since 2020. This profile was last refreshed in Aug 2026 and is updated monthly. Spotted something off? Use the “Suggest an edit” link near the top of the page.

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