645 Ventures
VC Fund
New York, United States
645 Ventures is an early-stage venture capital firm that partners with exceptional founders who are building iconic companies. We invest at the Seed and Series A stages and leverage our Voyager software platform to enable our Success team and Connected Network to help founders scale to the growth stage. Select portfolio companies that have reachedthe growth stage include Iterable, Goldbelly, Resident, Eden Health, FiscalNote, and Squire.We invest in four main areas: SaaS for the Second Wave, Citizen Professionals, The Engineering Value Chain Revolution, and Personalized Consumer Applications. You can read more here: https://645ventures.com/themes/645 Ventures has $200m+ in AUM and is growing fast with backing from leading institutional investors, including university endowments, funds of funds, and pension funds. We have over 35 active companies in our portfolio in the areas of enterprise SaaS, infrastructure software, and consumer technology. Several of our portfolio companies have been acquired by Google, Facebook, Expedia, and private equity firms.
- Total investments:
- 147
- Last investment:
- Lead investor:
- 30%
Last updated:
For AI agents: llms.txt
Industries 645 Ventures invests in
Stages 645 Ventures invests in
Countries 645 Ventures invests in
Round sizes
Contacts
| Name | Phone | Socials | |
|---|---|---|---|
Round size
- Seed
- $1.2M–$8.5M
- Series A
- $7M–$22M
- Series B
- $20M–$100M
Investment Focus
Industry
- Software 33 (22%)
- Information Technology 15 (10%)
- SaaS 11 (7%)
- E-Commerce 10 (7%)
- FinTech 8 (5%)
Stage
- Seed 52 (35%)
- Series A 35 (24%)
- Series B 11 (7%)
- Pre-Seed 4 (3%)
- Funding Round 4 (3%)
Country
- United States 73 (50%)
- United Kingdom 4 (3%)
- Spain 1 (1%)
- Mexico 1 (1%)
- Singapore 1 (1%)
Team
| Name | Title | Investments | Links | |
|---|---|---|---|---|
Alessio Fanelli
Principal, Investment & Research
|
Principal, Investment & Research | Total investments: 9 | Find email | |
Blake Jennelle
CTO In Residence
|
CTO In Residence | Total investments: 2 | Find email | |
Guerin Schwarberg
Vice President
|
Vice President | Total investments: 0 | Find email | |
Justin Fargione
Senior Full Stack Engineer
|
Senior Full Stack Engineer | Total investments: 0 | Find email | |
Matt Hawes
Associate
|
Associate | Total investments: 1 | Find email | |
| See all 17 team members → | ||||
Investments
| Company | Description | Round | Links |
|---|---|---|---|
Rivo
|
Rivo is a consumer fintech that sits on top of users’ existing bank accounts and automates idle cash management. It links to checking, keeps a user-set safe balance, sweeps excess cash into higher-yield instruments, and moves funds back before bills hit. | $2.7M / Seed / Aug 04, 2026 | |
Fish Audio
|
Fish Audio is an AI platform for expressive text‑to‑speech and voice cloning with pro‑grade voices and multilingual support. | $52M / Seed / Jul 27, 2026 | |
Upside
|
Upside is the only nationally scalable housing stability platform purpose-built for healthcare. The company partners with health plans and employers to identify and stabilize members and employees experiencing housing instability, connecting them to safe, supportive housing while reducing avoidable emergency utilization and improving healthoutcomes. Upside pairs dedicated Care Guides with AI-supported housing orchestration to deliver measurable results at scale. The platform serves Medicaid, Medicare Advantage, D-SNP, commercial, and employer-sponsored populations across the full housing continuum, from crisis intervention to long-term tenancy support. Founded in 2020 and headquartered in Fort Lauderdale, FL, Upside is redefining how healthcare addresses housing as a foundation of care. | $20M / Series A / Jun 25, 2026 | |
Sekai
|
Sekai is an AI‑powered content platform that enables users to create and live immersive, interactive stories | $20M / Series A / Jun 01, 2026 | |
AIVA
|
AIVA is an intelligence layer for hotels. | $1.5M / Pre-Seed / Jun 01, 2026 | |
General Analysis
|
General Analysis provides a comprehensive suite of AI safety tools, including run-time guardrails, red-teaming frameworks and more. | $10M / Seed / Apr 29, 2026 | |
Pomo
|
Pomo (pomohq) is a small, AI‑powered marketing‑tech startup that builds a unified platform of AI agents to plan, create, and optimize cross‑channel marketing campaigns for growth‑focused brands. It aims to replace fragmented tools and manual workflows with an integrated system that scales marketing operations and insights in one stack. | $4.5M / Seed / Apr 08, 2026 | |
Variance
|
Intrinsic is a software company that provides safety tools and API. | $21.5M / Series A / Mar 31, 2026 | |
Condor Software
|
Financial management software for biopharma | $24M / Series A / Mar 18, 2026 | |
UPTIQ
|
Uptiq is a technology company that provides an AI-driven platform designed to support financial services firms with real-time analytics, risk assessment, and decision-making workflows. The company’s platform uses machine learning to process and interpret large volumes of financial data, identify trends, and generate actionable insights that helpteams evaluate credit risk, detect anomalies, and inform portfolio strategies. Its tools support integration with existing data systems and workflows, enabling users to automate data ingestion, modeling, and reporting across lending, investment, and compliance functions.Uptiq also offers customizable dashboards and APIs that help financial analysts, risk officers, and product teams operationalize insights and align them with business objectives. The company works with banks, fintechs, and financial institutions to tailor AI models and analytic frameworks to specific use cases such as credit scoring, customer lifetime value prediction, and loss forecasting. Its platform emphasizes scalable data processing and transparent model outputs to support informed decision-making in financial operations. | $25M / Series B / Feb 12, 2026 | |
| See all 147 investments → | |||
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FAQ
What does 645 Ventures invest in?
645 Ventures invests primarily in Software, Information Technology and SaaS startups, most often at Seed and Series A stage. Most of the 147 investments tracked by Shizune back companies in United States. The Investment Focus section breaks down every industry, stage and country in the portfolio.
What is 645 Ventures's check size?
645 Ventures typically joins rounds of $1.2M–$8.5M at Seed, $7M–$22M at Series A and $20M–$100M at Series B. These ranges are 10th–90th percentile round sizes calculated from confirmed public funding rounds, so they are a realistic guide to the rounds 645 Ventures participates in.
How do I contact 645 Ventures?
Public channels for 645 Ventures include LinkedIn, X (Twitter) and the website linked on this profile. For a verified work email and phone number, create a free Shizune account — contact data is searched across 20+ sources and validated before delivery, so your outreach lands in the right inbox.
Who are the partners at 645 Ventures?
The team at 645 Ventures includes Alessio Fanelli (Principal, Investment & Research), Blake Jennelle (CTO In Residence) and Guerin Schwarberg (Vice President), among 17 team members tracked by Shizune. The Team section lists each member with their title, investment count and links.
Is Shizune's investor data accurate?
Yes — every stat on this profile is calculated from confirmed public funding rounds monitored across hundreds of sources since 2020. This profile was last refreshed in Aug 2026 and is updated monthly. Spotted something off? Use the “Suggest an edit” link near the top of the page.
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