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Brian Matesic, Principal at Norwest

Brian Matesic

Principal @ Norwest

San Francisco Bay Area, United States

Brian Matesic is a Principal at Norwest Venture Partners. He previously worked as the Principal of Blackstone Life Sciences at the Blackstone Group and Engagement Manager at McKinsey and Company. Brian attended Stanford University School of Medicine, Harvard Business School, and the University of Illinois Urbana-Champaign.

Total investments:
3
Last investment:
Lead investor:
33%

Last updated:

Industries Brian Matesic invests in

MedicalHealth CareBiotechnologyTherapeutics

Stages Brian Matesic invests in

Series A

Countries Brian Matesic invests in

United StatesSwitzerland

Investment Focus

Industry

  • Medical 2 (67%)
  • Health Care 2 (67%)
  • Biotechnology 2 (67%)
  • Therapeutics 1 (33%)

Country

  • United States 2 (67%)
  • Switzerland 1 (33%)

Investments

CompanyDescriptionRoundLinks
Mosanna Therapeutics Mosanna Therapeutics
Mosanna is a Biotech company based in Basel with a commitment to improving patient outcomes and quality of life in high unmet need diseases, applying a precision medicine approach. $80M / Series A / Jun 09, 2025
Callio Therapeutics Callio Therapeutics
Callio Therapeutics focuses on developing next-generation, multi-payload antibody-drug conjugates to maximize therapeutic benefits. $187M / Series A / Mar 03, 2025
Ouro Medicines Ouro Medicines
Ouroboros Medicines is a biotechnology company that specializes in immunology and focuses on treating long-term immune-mediated illnesses. The company addresses chronic immune-mediated conditions directly by integrating scientific knowledge, a proven history of progressing cell-depleting treatments through clinical trials, and a strong pipeline. $120M / Series A / Jan 10, 2025

Co-Investors

Norwest

About Norwest

VC Fund · Palo Alto, United States

Norwest is a venture capital and growth equity investment firm that specializes in venture and growth equity companies. Since its inception, it has invested in more than 600 companies and partnered with over 140 active companies across our venture and growth equity portfolio. The firm invests in early to late-stage companies across a wide range ofsectors with a focus on consumer, enterprise, and healthcare. It offers a deep network of connections, operating experience, and a wide range of impactful services to help CEOs and founders scale their businesses.

Norwest Contacts

NameEmailPhoneSocials
Brian Matesic
Brian Matesic Principal
Dave Zilberman
Dave Zilberman General Partner
David Su
David Su Partner
Dror Nahumi
Dror Nahumi General Partner
Edward Yip
Edward Yip Partner

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Platforms
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Oil and Gas
Retail
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SaaS
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Restaurants
Photography
Payments
Email
CleanTech
Energy
Marketplace
Organic Food
Fitness
Machine Learning
Health Care
Gaming
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Social Network
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Software
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FAQ

What does Brian Matesic invest in?

Brian Matesic invests primarily in Medical, Health Care and Biotechnology startups, most often at Series A stage. Most of the 3 investments tracked by Shizune back companies in United States. The Investment Focus section breaks down every industry, stage and country in the portfolio.

When did Brian Matesic last invest?

The most recent investment recorded for Brian Matesic closed in Jun 2025. Shizune tracks 3 investments in total for this profile, including round sizes, stages and portfolio companies, all sourced from confirmed public funding rounds and refreshed monthly.

Is Shizune's investor data accurate?

Yes — every stat on this profile is calculated from confirmed public funding rounds monitored across hundreds of sources since 2020. This profile was last refreshed in Aug 2026 and is updated monthly. Spotted something off? Use the “Suggest an edit” link near the top of the page.

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