# Brian Matesic

> Brian Matesic is a Series A investor at Norwest backing Medical and Health Care. See 3 investments, check sizes, portfolio. Updated Aug 2026.

- Type: Angel Investor
- Fund: [Norwest](https://shizune.co/investors/profile/norwest-venture-partners)
- Location: San Francisco Bay Area, United States
- Total investments: 3
- Last investment: Jun 2025
- Lead investor: 33%
- Last updated: Aug 2026
- LinkedIn: https://www.linkedin.com/in/brianmatesic

Brian Matesic is a Principal at Norwest Venture Partners. He previously worked as the Principal of Blackstone Life Sciences at the Blackstone Group and Engagement Manager at McKinsey and Company. Brian attended Stanford University School of Medicine, Harvard Business School, and the University of Illinois Urbana-Champaign.

## Investment focus

### Industry

| Industry | Investments | Share |
| --- | --- | --- |
| Medical | 2 | 67% |
| Health Care | 2 | 67% |
| Biotechnology | 2 | 67% |
| Therapeutics | 1 | 33% |

### Country

| Country | Investments | Share |
| --- | --- | --- |
| United States | 2 | 67% |
| Switzerland | 1 | 33% |

## Investments

| Company | Description | Amount | Stage | Date | Website |
| --- | --- | --- | --- | --- | --- |
| Mosanna Therapeutics | Mosanna is a Biotech company based in Basel with a commitment to improving patient outcomes and quality of life in high unmet need diseases, applying a precision medicine approach. | $80M | Series A | Jun 09, 2025 |  |
| Callio Therapeutics | Callio Therapeutics focuses on developing next-generation, multi-payload antibody-drug conjugates to maximize therapeutic benefits. | $187M | Series A | Mar 03, 2025 |  |
| Ouro Medicines | Ouroboros Medicines is a biotechnology company that specializes in immunology and focuses on treating long-term immune-mediated illnesses. The company addresses chronic immune-mediated conditions directly by integrating scientific knowledge, a proven history of progressing cell-depleting treatments through clinical trials, and a strong pipeline. | $120M | Series A | Jan 10, 2025 |  |

3 of 3 investments shown.

## Co-investors
- [Boyu Capital](https://shizune.co/investors/profile/boyu-capital) — VC Fund, 1 deal together
- [Broadview Ventures](https://shizune.co/investors/profile/broadview-ventures) — VC Fund, 1 deal together
- [ClavystBio](https://shizune.co/investors/profile/clavystbio) — VC Fund, 1 deal together
- [EDBI](https://shizune.co/investors/profile/edbi) — VC Fund, 1 deal together
- [Forbion Capital Partners](https://shizune.co/investors/profile/forbion-capital-partners) — VC Fund, 1 deal together
- [Forty51 Ventures](https://shizune.co/investors/profile/forty51-ventures) — VC Fund, 1 deal together

## About Norwest

VC Fund · Palo Alto, United States

Norwest is a venture capital and growth equity investment firm that specializes in venture and growth equity companies. Since its inception, it has invested in more than 600 companies and partnered with over 140 active companies across our venture and growth equity portfolio. The firm invests in early to late-stage companies across a wide range ofsectors with a focus on consumer, enterprise, and healthcare. It offers a deep network of connections, operating experience, and a wide range of impactful services to help CEOs and founders scale their businesses.

5 contacts available at Norwest.

| Name | Title | Profile |
| --- | --- | --- |
| Brian Matesic | Principal | https://shizune.co/investors/profile/brian-matesic-85fa |
| Dave Zilberman | General Partner | https://shizune.co/investors/profile/david-zilberman |
| David Su | Partner | https://shizune.co/investors/profile/david-su-2 |
| Dror Nahumi | General Partner | https://shizune.co/investors/profile/dror-nahumi |
| Edward Yip | Partner | https://shizune.co/investors/profile/edward-yip |

## Similar investors

### Similar stage
- [Antler](https://shizune.co/investors/profile/antler-be9c) — VC Fund
- [Alumni Ventures](https://shizune.co/investors/profile/alumni-ventures-group) — VC Fund
- [General Catalyst](https://shizune.co/investors/profile/general-catalyst-partners) — VC Fund

## FAQ

### What does Brian Matesic invest in?

Brian Matesic invests primarily in Medical, Health Care and Biotechnology startups, most often at Series A stage. Most of the 3 investments tracked by Shizune back companies in United States. The Investment Focus section breaks down every industry, stage and country in the portfolio.

### When did Brian Matesic last invest?

The most recent investment recorded for Brian Matesic closed in Jun 2025. Shizune tracks 3 investments in total for this profile, including round sizes, stages and portfolio companies, all sourced from confirmed public funding rounds and refreshed monthly.

### Is Shizune's investor data accurate?

Yes — every stat on this profile is calculated from confirmed public funding rounds monitored across hundreds of sources since 2020. This profile was last refreshed in Aug 2026 and is updated monthly. Spotted something off? Use the “Suggest an edit” link near the top of the page.

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