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Francesco De Rubertis, Director at Critical Pressure

Francesco De Rubertis

Director @ Critical Pressure

Geneva, Switzerland

Francesco De Rubertis is a Series A investor at Critical Pressure in Geneva focused on Biotechnology and Pharmaceutical. Francesco De Rubertis is the co-founder and Partner at Medicxi. He is the Board of Director at Ottimo Pharma. He attended the University of Geneva.

Total investments:
21
Last investment:
Lead investor:
38%

Last updated:

Industries Francesco De Rubertis invests in

BiotechnologyPharmaceuticalHealth CareMedicalTherapeutics

Stages Francesco De Rubertis invests in

Series ASeries BSeedSeries CPre-Seed

Countries Francesco De Rubertis invests in

United StatesChinaSpainIrelandSwitzerland

Round sizes

Seed $1.2M–$100MSeries A $11M–$140MSeries B $13M–$132M

Contacts

TypeContactValidation
Work email
Personal email
Work phone
Personal phone
Socials

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Round size

Seed
$1.2M–$100M
Series A
$11M–$140M
Series B
$13M–$132M

Investment Focus

Industry

  • Biotechnology 9 (43%)
  • Pharmaceutical 5 (24%)
  • Health Care 4 (19%)
  • Medical 3 (14%)
  • Therapeutics 3 (14%)
See all 13 industries →

Stage

  • Series A 6 (29%)
  • Series B 5 (24%)
  • Seed 4 (19%)
  • Series C 2 (10%)
  • Pre-Seed 1 (5%)
See all 7 stages →

Country

  • United States 5 (24%)
  • China 1 (5%)
  • Spain 1 (5%)
  • Ireland 1 (5%)
  • Switzerland 1 (5%)

Investments

CompanyDescriptionRoundLinks
D3 Bio D3 Bio
D3 Bio is a globally focused biotechnology company focusing on developing and registration of innovative medicines in oncology and immunology. At D3 Bio, our new medicine development approach is fundamentally differentiated. We do not just only start with science in the lab. First, we pinpoint the greatest unmet patient and market needs – whereexisting standard-of-care approaches yield unsatisfactory clinical outcomes. Then we take those insights into the lab to guide the identification of fit for purpose science and technology and define our drug development path. $108M / Series B / Dec 09, 2025
Ottimo Pharma Ottimo Pharma
Ottimo Pharma is a private biotechnology company dedicated to enhancing cancer treatment outcomes and minimizing the overall healthcare burden. $140M / Series A / Dec 19, 2024
Ottimo Pharma Ottimo Pharma
Ottimo Pharma is a private biotechnology company dedicated to enhancing cancer treatment outcomes and minimizing the overall healthcare burden. Seed / Oct 28, 2024
D3 Bio D3 Bio
D3 Bio is a globally focused biotechnology company focusing on developing and registration of innovative medicines in oncology and immunology. At D3 Bio, our new medicine development approach is fundamentally differentiated. We do not just only start with science in the lab. First, we pinpoint the greatest unmet patient and market needs – whereexisting standard-of-care approaches yield unsatisfactory clinical outcomes. Then we take those insights into the lab to guide the identification of fit for purpose science and technology and define our drug development path. $62M / Series A / Apr 08, 2024
Alys Pharmaceuticals Alys Pharmaceuticals
Alys Pharmaceuticals engages in immuno-dermatology services. The company is reshaping the treatment landscape through advanced scientific innovations and a strong research and development-focused multi-platform pipeline. Alys emerged as a result of the strategic aggregation of 6 asset-centric companies backed by Medicxi. $100M / Seed / Feb 12, 2024
Aldena Therapeutics Aldena Therapeutics
Aldena Therapeutics is a private biotech startup that invented siRNA-based treatments for dermatological conditions. $30M / Series A / Mar 16, 2023
Velada Velada
Velada is an app that helps users find the ideal restaurant for any occasion by utilizing data to provide personalized recommendations. Tjey also have a proprietary algorithm that uses data from its users' preferences and app behavior to make personalized recommendations, making Velada the first smart restaurant guide. However, without an appor resource that provides a dedicated local guide, travelers frequently find themselves in tourist traps when it comes to their culinary experience. $1.2M / Seed / Oct 05, 2022
Velada Velada
Velada is an app that helps users find the ideal restaurant for any occasion by utilizing data to provide personalized recommendations. Tjey also have a proprietary algorithm that uses data from its users' preferences and app behavior to make personalized recommendations, making Velada the first smart restaurant guide. However, without an appor resource that provides a dedicated local guide, travelers frequently find themselves in tourist traps when it comes to their culinary experience. $1.1M / Pre-Seed / Oct 05, 2022
Rivus Pharmaceuticals Rivus Pharmaceuticals
Rivus Pharmaceuticals operates as a biopharmaceutical company dedicated to improving cardio-metabolic health. Rivus Pharmaceuticals is dedicated to improving cardio-metabolic health by developing controlled metabolic accelerators (CMAs) that address the underlying metabolic risk factors for cardiovascular mortality and morbidity. $132M / Series B / Sep 22, 2022
Rivus Pharmaceuticals Rivus Pharmaceuticals
Rivus Pharmaceuticals operates as a biopharmaceutical company dedicated to improving cardio-metabolic health. Rivus Pharmaceuticals is dedicated to improving cardio-metabolic health by developing controlled metabolic accelerators (CMAs) that address the underlying metabolic risk factors for cardiovascular mortality and morbidity. $35M / Series A / Jul 20, 2021
See all 21 investments →

Co-Investors

Critical Pressure

About Critical Pressure

VC Fund · Cambridge, United Kingdom

Critical Pressure is a provider of drugs designed to treat to treat vascular dysfunction and shock. The company's technology has the potential to change clinical practice without the potentially harmful effects of excess fluid administration and toxicities associated with the currently available catecholamine-based vasoactive agents, providingthe possibility of supportive therapy during the critical period of haemodynamic compromise.

Critical Pressure Contacts

NameEmailPhoneSocials
Bob Schroff
Bob Schroff COO
David Grainger
David Grainger CEO
James M. Leiper
James M. Leiper CSO
Simon Lambden
Simon Lambden CMO

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FAQ

What does Francesco De Rubertis invest in?

Francesco De Rubertis invests primarily in Biotechnology, Pharmaceutical and Health Care startups, most often at Series A and Series B stage. Most of the 21 investments tracked by Shizune back companies in United States. The Investment Focus section breaks down every industry, stage and country in the portfolio.

What is Francesco De Rubertis's check size?

Francesco De Rubertis typically joins rounds of $1.2M–$100M at Seed, $11M–$140M at Series A and $13M–$132M at Series B. These ranges are 10th–90th percentile round sizes calculated from confirmed public funding rounds, so they are a realistic guide to the rounds Francesco De Rubertis participates in.

How do I contact Francesco De Rubertis?

Public channels for Francesco De Rubertis include LinkedIn, X (Twitter) and the website linked on this profile. For a verified work email and phone number, create a free Shizune account — contact data is searched across 20+ sources and validated before delivery, so your outreach lands in the right inbox.

When did Francesco De Rubertis last invest?

The most recent investment recorded for Francesco De Rubertis closed in Dec 2025. Shizune tracks 21 investments in total for this profile, including round sizes, stages and portfolio companies, all sourced from confirmed public funding rounds and refreshed monthly.

Is Shizune's investor data accurate?

Yes — every stat on this profile is calculated from confirmed public funding rounds monitored across hundreds of sources since 2020. This profile was last refreshed in Aug 2026 and is updated monthly. Spotted something off? Use the “Suggest an edit” link near the top of the page.

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