Brian Matthews
Co-Founder & General Partner @ Cultivation Capital
St Louis, United States
Brian Matthews is a Co-Founder and a General Partner at Cultivation Capital. In addition, he is a Founder of River City Internet Group. Brian is a serial entrepreneur having co-founded and assisted in the sale of the following technology companies: Primary Network to Mpower Communications (MPWR) in 2000, Primary Webworks to Perficient (PRFT) in2001, CDM Fantasy Sports to Liberty Media (LCAPA) in 2006, and IntraISP to Clearwire Communications (CLWR) in 2007.Brian continues to focus on investments in early stage companies and sits on the boards of Perficient, LockerDome, NoonLight, S4, SimpleRose, TopOpps, Aisle411, Hatchbuck, Tunespeak, SixThirty, Hostirian, and non-profit boards GlobalHack, Givable, Friends of T-REX.Brian Matthews attended Missouri University of Science and Technology.
- Total investments:
- 60
- Last investment:
- Lead investor:
- 58%
Last updated:
For AI agents: llms.txt
Industries Brian Matthews invests in
Stages Brian Matthews invests in
Countries Brian Matthews invests in
Round sizes
Round size
- Seed
- $500k–$3.9M
- Angel
- $250k–$500k
- Series A
- $1.4M–$10M
Investment Focus
Industry
- Software 15 (25%)
- Information Technology 8 (13%)
- SaaS 6 (10%)
- Mobile 5 (8%)
- Analytics 5 (8%)
Stage
- Seed 24 (40%)
- Series A 11 (18%)
- Angel 3 (5%)
- Funding Round 3 (5%)
- Pre-Seed 2 (3%)
Country
- United States 33 (55%)
- Canada 1 (2%)
- Argentina 1 (2%)
Investments
| Company | Description | Round | Links |
|---|---|---|---|
Shelfmark
|
Shelfmark is an intelligence platform that brings the innovation to DSD to provide inventory insights for suppliers, and eCommerce partner. | $4.9M / Seed / Jul 14, 2026 | |
FinOpsly
|
FinOpsly is on a mission to redefine cloud cost management through the power of artificial intelligence. As your AI Copilot for implementing FinOps, the platform delivers a comprehensive, single-view solution for multi-cloud environments. It delivers complete visibility and transparency into unit cost economics, equips you with intelligentrecommendations and anomaly detection, and offers virtual tagging and governance capabilities, all through a user-friendly interface designed to drive collaboration and accountability across finance, product and engineering teams. FinOpsly isn't just about cost savings – it’s about enhancing the quality and velocity of your cloud investments. | $6.4M / Seed / Jan 14, 2026 | |
Detect Auto
|
Detect Auto is a computer vision system that uses Wi-Fi cameras to provide actionable insights to improve auto repair service centers. | $2.9M / Seed / Dec 08, 2025 | |
OpsCompanion
|
Your team is shipping with AI. Agents are writing code, changing your infrastructure, pushing to production. Nobody tracks what those agents did last week, or why a similar change broke production three months ago. OpsCompanion does. It maps how your systems behave over time, so when an AI coding tool is about to repeat a mistake or cross aboundary your team set, it catches the problem before your customers do. Every agent action, every incident, every fix builds operational memory specific to your environment. That memory feeds back into agent sessions, giving your AI tools the guardrails and context they need to make better decisions automatically.We built OpsCompanion for mid-market engineering teams that need AI agent governance, monitoring, and audit trails without hiring a dedicated SRE or building internal tooling from scratch. Connect your tools and go live in under two weeks.You started building because you had something worth making. OpsCompanion makes sure it stays that way. | Pre-Seed / Sep 05, 2025 | |
Avol Aerospace
|
Avol Aerospace is a startup that develops autonomous electric aircraft specifically for time-critical cargo delivery. The company’s service focuses on delivering medical-logistics shipments—such as blood, stem cells, tissues, or lab specimens—between healthcare centers, enabling pickup in 30 minutes or less and costs comparable to or below groundtransport. Avol’s proprietary aircraft use a blended-wing design to maximize cargo volume and reduce cost per flight, aiming to provide zero-emissions, high-efficiency alternatives for critical logistics. | $3.8M / Seed / Aug 28, 2025 | |
Solis Agrosciences
|
Solis Agrosciences provides R&D crop development services to Agtech companies. Founded in 2021, Solis Agrosciences is a plant science services company on a mission to accelerate the pace of scientific discovery and commercialization. | $500K / Series A / Feb 25, 2025 | |
VedaPointe
|
VedaPointe provides strategic expertise, incubation assistance, and technical services for clinical and administrative healthcare data. The company was founded in 2019 and is based in St. Louis, Missouri, United States. | $2.7M / Seed / Oct 15, 2024 | |
OpsLab
|
OpsLab is a company that designs predictive operations tracking and disruption management platforms for airlines, hospitals, and defense organizations. | $5M / Seed / Nov 15, 2023 | |
Dataplant
|
Dataplant is an automated customer management platform. They provide the post-sales teams with the insights needed to proactively engage with each of their customers. They build a report or create automation rules. They build models and boost post-sales activities. The root analysis solves this by utilizing AI to provide unbiased, data-driveninsights. | $500K / Seed / Mar 02, 2023 | |
Paytient
|
Paytient helps people make better healthcare decisions by improving their ability to pay for care. We do this by bundling or embedding payment solutions like Paytient's Health Payment Account (HPA) or the Medicare Prescription Payment Plan alongside commercial, individual ACA, and Medicare plans. Armed with the power to decide how and whenthey pay for care, our users change their behavior in ways that improve their health and lower costs for everyone, which benefits the plan sponsor. By 2025, Paytient will serve 25M lives and 6,000 enterprise clients including leading employers and payers such as Anthem, Centene, Cigna, R.R. Donnelley, and Hyatt Hotels. The company has earned a 90 NPS and 4.9 stars on Trustpilot. | $33M / Series B / Jan 10, 2023 | |
| See all 60 investments → | |||
Co-Investors
About Cultivation Capital
Cultivation Capital is a venture capital firm that manages a family of funds focused on early-stage investing. Most of our initial investments are during a startup’s Seed or Series A phase, and our initial checks range from $500k – $3.5M. Our industries of focus include life sciences and health tech, software and IT, agriculture tech, andgeospatial tech.
Cultivation Capital Contacts
| Name | Phone | Socials | |
|---|---|---|---|
Alana Mann
Principal
|
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Andy Dearing
General Partner
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Brian Matthews
Co-Founder & General Partner
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David Smoller
General Partner - Life Sciences Fund
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Dean VandeKamp
General Partner
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FAQ
What does Brian Matthews invest in?
Brian Matthews invests primarily in Software, Information Technology and SaaS startups, most often at Seed and Series A stage. Most of the 60 investments tracked by Shizune back companies in United States. The Investment Focus section breaks down every industry, stage and country in the portfolio.
What is Brian Matthews's check size?
Brian Matthews typically joins rounds of $500k–$3.9M at Seed, $250k–$500k at Angel and $1.4M–$10M at Series A. These ranges are 10th–90th percentile round sizes calculated from confirmed public funding rounds, so they are a realistic guide to the rounds Brian Matthews participates in.
When did Brian Matthews last invest?
The most recent investment recorded for Brian Matthews closed in Jul 2026. Shizune tracks 60 investments in total for this profile, including round sizes, stages and portfolio companies, all sourced from confirmed public funding rounds and refreshed monthly.
Is Shizune's investor data accurate?
Yes — every stat on this profile is calculated from confirmed public funding rounds monitored across hundreds of sources since 2020. This profile was last refreshed in Aug 2026 and is updated monthly. Spotted something off? Use the “Suggest an edit” link near the top of the page.
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