Twine Ventures
VC Fund
San Francisco, United States
Twine Ventures is an early-stage venture capital firm that focuses on human health, climate, and financial empowerment. The firm was founded by Leshika Samarasinghe in 2021 and is based in San Francisco, California, United States.
- Total investments:
- 21
- Last investment:
- Lead investor:
- 0%
- Fund size:
- $29M
- Last fund:
Last updated:
For AI agents: llms.txt
Industries Twine Ventures invests in
Stages Twine Ventures invests in
Countries Twine Ventures invests in
Round sizes
Contacts
| Name | Phone | Socials | |
|---|---|---|---|
Round size
- Seed
- $4M–$31M
- Pre-Seed
- $500k–$4M
- Series A
- $20M–$100M
Investment Focus
Industry
- Health Care 9 (43%)
- Software 6 (29%)
- Artificial Intelligence 6 (29%)
- Medical 3 (14%)
- Machine Learning 3 (14%)
Stage
- Seed 8 (38%)
- Series A 6 (29%)
- Pre-Seed 5 (24%)
- Series B 1 (5%)
Country
- United States 15 (71%)
- Mexico 1 (5%)
- United Kingdom 1 (5%)
Team
| Name | Title | Investments | Links | |
|---|---|---|---|---|
Leshika Samarasinghe
Founder and General Partner
|
Founder and General Partner | Total investments: 3 | Find email |
Investments
| Company | Description | Round | Links |
|---|---|---|---|
| Penelope Health provides API infrastructure for real-time payer medical policy intelligence. The company's knowledge graph structures medical coverage policies from major payers into programmable data, making policy information instantly accessible through a unified API. The platform delivers contextual code coverage across >500,000 extracted CPT, HCPCS, and ICD codes, with daily policy updates that track changes as they happen. Penelope's API allows organizations to query specific code coverage, compare payer policies, and understand medical necessity requirements without manual document review. Use cases span revenue cycle management (claim scrubbing, prior authorization, appeals automation), payer competitive intelligence, medical device field sales coverage verification, and healthtech companies building billing capabilities. The platform serves as neutral policy infrastructure, aggregating coverage criteria from UnitedHealthcare, Cigna, Aetna, Humana, and other major payers. Founded by a Cambridge-trained physician and ML engineer, Penelope Health operates as the policy intelligence layer for healthcare, turning scattered PDF documents into structured, real-time data. | $100M / Series A / Sep 18, 2026 | ||
| Rowspace provides an AI platform for financial institutions to make decisions using proprietary data. The platform focuses on organizing, processing, and analyzing internal datasets alongside market information. It applies artificial intelligence and machine learning techniques tailored to financial workflows. Rowspace supports use cases such asinvestment research, risk analysis, and product strategy. The company works with financial services firms that want to operationalize data for day-to-day and strategic decisions. | $50M / Series A / Feb 25, 2026 | ||
| Rowspace provides an AI platform for financial institutions to make decisions using proprietary data. The platform focuses on organizing, processing, and analyzing internal datasets alongside market information. It applies artificial intelligence and machine learning techniques tailored to financial workflows. Rowspace supports use cases such asinvestment research, risk analysis, and product strategy. The company works with financial services firms that want to operationalize data for day-to-day and strategic decisions. | Seed / Feb 25, 2026 | ||
| Alaffia Health offers artificial intelligence solutions that support health plan claims operations by automating and improving clinical review workflows. Its platform uses AI agents to analyze complex medical claims data, extract structured clinical facts, and assist with payment integrity, utilization management, and appeals processing. Thecompany’s tools integrate with existing claims systems to prioritize cases, support clinician review, and help identify errors, waste, and inconsistencies before payment. Alaffia Health combines machine learning with clinician oversight to enhance accuracy in claims decisions and streamline administrative tasks for health insurance payers and related organizations. | $55M / Series B / Feb 03, 2026 | ||
| AI-native EHR and practice management system with real-time patient monitoring for private practices and therapy networks. Increase your efficiency via automated documentation, scheduling, billing, and teletherapy— all while leveraging advanced data from patients to personalize care. | $4M / Seed / Jan 06, 2026 | ||
| Ava Financial is a fintech company that offers a mobile app-based credit-building platform aimed at individuals looking to establish or improve their credit history. Its main products include the Ava Credit Builder Card, which features a credit line usable at select streaming and online merchant platforms, and the Save & Build Credit Account, asmall secured loan program where users make monthly payments for 12 months and receive a cash refund at the end of the term. The company reports on-time payment history to all three major U.S. credit bureaus—and claims to help users begin seeing credit score improvements quickly, often within days after enrollment. Users link a checking account, pay a monthly subscription fee, and are encouraged to keep credit utilization low. | $15.5M / Seed / Oct 24, 2025 | ||
| Alchemy creates and implements clinical pharmacy programs and deploys technology products that use the pharmacy to expand access for patients, improve health outcomes, and increase the financial impact of a clinic's pharmacy program. | $31M / Seed / Oct 15, 2024 | ||
| Airship provides HVAC technicians with point-of-sale software. | $4M / Pre-Seed / Sep 30, 2024 | ||
| Airship specializes in providing a comprehensive suite of software tools and financial products tailored specifically for owner-operators in the home services industry. It's mission is to empower these entrepreneurs by streamlining their operations, enhancing customer engagement, and facilitating business growth. With innovative solutions,home service providers can manage their workflows more efficiently, access critical financial resources, and ultimately scale their businesses with confidence | $4M / Pre-Seed / Sep 30, 2024 | ||
| Grupago is pioneering digital microcredit for small and mid-sized businesses (SMBs) in Latin America, leveraging artificial intelligence, group collateral and community distribution to extend credit to micro-SMBs across the region who have been shut out of traditional SMB lending avenues. | $4.3M / Seed / Mar 12, 2024 | ||
| See all 21 investments → | |||
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FAQ
What does Twine Ventures invest in?
Twine Ventures invests primarily in Health Care, Software and Artificial Intelligence startups, most often at Seed and Series A stage. Most of the 21 investments tracked by Shizune back companies in United States. The Investment Focus section breaks down every industry, stage and country in the portfolio.
What round sizes does Twine Ventures invest in?
Twine Ventures typically joins rounds of $4M–$31M at Seed, $500k–$4M at Pre-Seed and $20M–$100M at Series A. These are whole funding-round sizes, not Twine Ventures's own check, which is rarely disclosed: the 10th–90th percentile of the confirmed public funding rounds Twine Ventures took part in.
How do I contact Twine Ventures?
Public channels for Twine Ventures include LinkedIn and the website linked on this profile. For a verified work email and phone number, create a free Shizune account — contact data is searched across 20+ sources and validated before delivery, so your outreach lands in the right inbox.
Who are the partners at Twine Ventures?
The team at Twine Ventures includes Leshika Samarasinghe (Founder and General Partner). The Team section lists each member with their title, investment count and links.
Is Shizune's investor data accurate?
Yes — every stat on this profile is calculated from confirmed public funding rounds monitored across hundreds of sources since 2020. This profile was last refreshed in Oct 2026 and is updated monthly. Spotted something off? Use the “Suggest an edit” link near the top of the page.
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