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Sara Eshelman, Principal at Spero Ventures

Sara Eshelman

Principal @ Spero Ventures

New York, United States

Sara Eshelman is a Series A investor at Spero Ventures in New York focused on Health Care and Biotechnology. Sara Eshelman is the Principal at Spero Ventures.

Total investments:
7
Last investment:
Lead investor:
71%

Last updated:

Industries Sara Eshelman invests in

Health CareBiotechnologyMedicalArtificial IntelligenceB2B

Stages Sara Eshelman invests in

Series ASeries B

Countries Sara Eshelman invests in

United States

Contacts

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Investment Focus

Industry

  • Health Care 3 (43%)
  • Biotechnology 3 (43%)
  • Medical 2 (29%)
  • Artificial Intelligence 2 (29%)
  • B2B 1 (14%)
See all 14 industries →

Stage

  • Series A 5 (71%)
  • Series B 2 (29%)

Investments

CompanyDescriptionRoundLinks
Tiny Health is the leading microbiome health platform for people tackling chronic conditions or looking to optimize overall health. Tiny Health’s Gut Health Test is the first-ever at-home gut microbiome test for pregnant moms and babies to use shotgun metagenomics, and the company now also offers tests for older children and adults, as well asVaginal Health Tests.To date, 30,000 families have trusted Tiny Health to correct imbalances in the gut and vaginal microbiome, and optimize their lifelong health. By taking evidence-based action steps from a dietary, supplement and lifestyle based on personalized results, we've helped people reduce severe symptoms and in some cases even reverse chronic conditions. Tiny Health's team includes top scientists, physicians, and microbiologists from Mayo Clinic, Johns Hopkins, Stanford, WashU, Cornell, and Harvard Medical School. For more information, visit tinyhealth.com and poweredbytiny.com $33M / Series B / Sep 29, 2026
Persist assist pharmaceutical companies in developing long-acting formulations 50% faster. Because the formulation development process is manual and relies on scientific intuition, it takes a pharmaceutical company 5-10 years to develop a long acting formulation for a drug. This effort is divided into five years of pre-clinical development and fiveyears of clinical testing. Their goal is to use machine learning and automation to reduce the time required for pre-clinical formulation development to three months, making the formulation development process 50% faster. $12M / Series A / Mar 19, 2025
Aralez Bio uses engineered enzymes to make valuable products in a sustainable way.The company has invented a novel enzymatic method for synthesizing noncanonical amino acids (ncAAs) also called unusual or unnatural amino acids. Its proprietary approach enables over 100 ncAAs to be synthesized with perfect enantiopurity in just a single step, withwater as the only byproduct $12M / Series A / Oct 29, 2024
Tiny Health is the leading microbiome health platform for people tackling chronic conditions or looking to optimize overall health. Tiny Health’s Gut Health Test is the first-ever at-home gut microbiome test for pregnant moms and babies to use shotgun metagenomics, and the company now also offers tests for older children and adults, as well asVaginal Health Tests.To date, 30,000 families have trusted Tiny Health to correct imbalances in the gut and vaginal microbiome, and optimize their lifelong health. By taking evidence-based action steps from a dietary, supplement and lifestyle based on personalized results, we've helped people reduce severe symptoms and in some cases even reverse chronic conditions. Tiny Health's team includes top scientists, physicians, and microbiologists from Mayo Clinic, Johns Hopkins, Stanford, WashU, Cornell, and Harvard Medical School. For more information, visit tinyhealth.com and poweredbytiny.com $8.5M / Series A / Mar 05, 2024
OOVA is a fertility diagnostic company that spun out from Mount Sinai Hospital in New York City. Using patent pending biochemistry and artificial intelligence, OOVA learns a woman’s fertility profile by accurately measuring key hormones over time through daily urine samples. By monitoring this critical balance of hormones, OOVA can help a woman getpregnant, identify reasons she is having trouble getting pregnant, and even expose reproductive health issues like PCOS. $10.3M / Series A / Jun 12, 2023
Hyro creates plug-and-play conversational AI assistants by seamlessly ingesting data on digital channels to allow users to interact with information via voice or chat simply and intuitively, allowing for increased engagement and conversions. Unlike existing solutions, Hyro provides organisations with frictionless deployment and maintenanceprocesses by automatically building a knowledge graph out of their existing content without any integration, playbooks, or training data. $20M / Series B / May 31, 2023
Hyro creates plug-and-play conversational AI assistants by seamlessly ingesting data on digital channels to allow users to interact with information via voice or chat simply and intuitively, allowing for increased engagement and conversions. Unlike existing solutions, Hyro provides organisations with frictionless deployment and maintenanceprocesses by automatically building a knowledge graph out of their existing content without any integration, playbooks, or training data. $10.5M / Series A / May 25, 2021

Co-Investors

Spero Ventures

About Spero Ventures

VC Fund · Redwood City, United States

Spero Ventures makes venture investments in the things that make life worth living - wellbeing; sustainability; learning, work, and play.

Spero Ventures Contacts

NameEmailPhoneSocials
Andrew Parker
Andrew Parker General Partner
Brandon Walker Investor
Marc Tarpenning
Marc Tarpenning Venture Partner
Sara Eshelman
Sara Eshelman Principal
Shripriya Mahesh
Shripriya Mahesh Co-Founder and General Partner

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FAQ

What does Sara Eshelman invest in?

Sara Eshelman invests primarily in Health Care, Biotechnology and Medical startups, most often at Series A and Series B stage. Most of the 7 investments tracked by Shizune back companies in United States. The Investment Focus section breaks down every industry, stage and country in the portfolio.

How do I contact Sara Eshelman?

Public channels for Sara Eshelman include LinkedIn and X (Twitter). For a verified work email and phone number, create a free Shizune account — contact data is searched across 20+ sources and validated before delivery, so your outreach lands in the right inbox.

When did Sara Eshelman last invest?

The most recent investment recorded for Sara Eshelman closed in Sep 2026. Shizune tracks 7 investments in total for this profile, including round sizes, stages and portfolio companies, all sourced from confirmed public funding rounds and refreshed monthly.

Is Shizune's investor data accurate?

Yes — every stat on this profile is calculated from confirmed public funding rounds monitored across hundreds of sources since 2020. This profile was last refreshed in Oct 2026 and is updated monthly. Spotted something off? Use the “Suggest an edit” link near the top of the page.

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