Nicolas Dessaigne
Group Partner @ Y Combinator
San Francisco, United States
Nicolas Dessaigne is a pre-seed investor at Y Combinator in San Francisco focused on Artificial Intelligence and Software. Nicolas Dessaigne is based out of San Francisco, California, and is the General Partner of Y Combinator. Nicolas previously worked at Algolia as a Co Founder & CEO. Nicolas Dessaigne attended the University of Nantes.
- Total investments:
- 242
- Last investment:
- Lead investor:
- 56%
Last updated:
For AI agents: llms.txt
Industries Nicolas Dessaigne invests in
Stages Nicolas Dessaigne invests in
Countries Nicolas Dessaigne invests in
Round sizes
Contacts
| Type | Contact | Validation |
|---|---|---|
| Work email | ||
| Personal email | ||
| Work phone | ||
| Personal phone | ||
| Socials |
Round size
- Seed
- $1.6M–$10M
- Pre-Seed
- $500k–$647k
- Series A
- $8M–$25M
Investment Focus
Industry
- Artificial Intelligence 100 (41%)
- Software 91 (38%)
- SaaS 42 (17%)
- Information Technology 35 (14%)
- Developer Tools 33 (14%)
Stage
- Pre-Seed 145 (60%)
- Seed 59 (24%)
- Series A 24 (10%)
- Series B 2 (1%)
- Funding Round 2 (1%)
Country
- United States 140 (58%)
- France 27 (11%)
- United Kingdom 10 (4%)
- Germany 7 (3%)
- Norway 2 (1%)
Investments
| Company | Description | Round | Links |
|---|---|---|---|
| OpEra Technologies is the AI decision engine for factories, warehouses and fleets. Companies with physical operations make thousands of decisions every day, and we help their teams make the best one at every step from production to delivery: (1) Planning: how much to make, buy and stock. (2) Scheduling: what runs when, and who works on what. (3) Allocation: which warehouse or store gets each order. (4) Routing: boat, plane or truck, and which route each one takes. Founded out of MIT's Operations Research Center and backed by Y Combinator (Fall 2026). | $500K / Pre-Seed / Sep 21, 2026 | ||
| Bravi offers an AI‑powered voice and chat assistant that handles lead qualification, appointment booking, and CRM integration. | $1.8M / Pre-Seed / Sep 15, 2026 | ||
| Playabl is an AI-powered platform for creating web games and interactive experiences through natural language chat. The product lets users describe game ideas in plain text and generates playable browser-based drafts with core loops, controls, user interface, and starter content. Creators can refine difficulty, rules, level layouts, visuals, andpacing by iterating in a conversational interface rather than writing code or configuring a separate engine. The platform also supports remixing existing games, publishing playables via shareable links, and using templates to avoid starting from a blank project. Built-in tools cover asset generation, basic 3D modeling, animation presets, and visual customization to support a range of desktop-style games, mobile-first prototypes, playable ads, and lightweight interactive web experiences. | $500K / Pre-Seed / Jun 16, 2026 | ||
| Lumius develops 3D ultrasound hardware and imaging technology for medical applications. The company offers a real-time 3D imaging solution focused initially on image-guided vascular access. Its product line includes a plugin module that adds 3D functionality to existing ultrasound systems and a full probe with integrated 3D capability. Lumius usesDiffractive Acoustic Tomography to provide isotropic 3D imaging with a defined field of view in a compact, portable device. The technology is designed to make 3D ultrasound more accessible in settings where conventional matrix-array probes are costly. Lumius targets healthcare providers and researchers who require intuitive volumetric visualization for ultrasound-guided procedures. The products are currently not cleared for medical use and are not intended to diagnose or treat medical conditions. | $500K / Pre-Seed / Jun 16, 2026 | ||
| BioStack Platforms develops data infrastructure and simulation environments for healthcare and drug discovery AI. The company builds proprietary preclinical and clinical data pipelines that connect longitudinal, multimodal medical data such as EHRs, imaging, ECGs, labs, notes, audio, and outcomes. It structures this information intomachine-learning-ready datasets and workflow-aligned simulation environments rather than static text corpora. These environments support post-training, reinforcement learning, and multi-agent reasoning for medical AI systems. BioStack Platforms serves AI labs, biotechnology startups, pharmaceutical teams, and data providers that need domain-specific datasets, causal inference support, and robust reward models. Its offerings are used to test, evaluate, and train medical AI models on real-world clinical workflows before deployment in practice. | $500K / Pre-Seed / Jun 16, 2026 | ||
| Adialante develops deployable, clinical-grade MRI systems designed to reduce the cost and footprint of traditional scanners. The company focuses on a novel B1 encoding architecture that minimizes or removes B0 gradient coils to enable quieter, portable neuroimaging. Its platform targets cancer and brain screening in clinics and communities thatlack conventional MRI infrastructure. Adialante also offers workshops, innovation courses, and consultation services related to clinical partnerships and healthcare technology development. Customers include healthcare providers, clinics, and research organizations seeking accessible MRI solutions. | $500K / Pre-Seed / Jun 16, 2026 | ||
| Infera develops an AI operating system for laboratories that converts scientific protocols into validated, instrument ready workflows. | $500K / Pre-Seed / Jun 16, 2026 | ||
| Trellis is a B2B SaaS (Business-to-Business Software as a Service) platform that provides enterprise AI agents to automate short-term rental operations, orchestrating guest relations and field workflows. | $500K / Pre-Seed / Jun 16, 2026 | ||
| Netter is a data management company that offers a platform to centralize data to deploy analytics, workflows and machine learning models. | $500K / Pre-Seed / Jun 16, 2026 | ||
| Wato is a shared AI workspace that connects agents, workflows, and team memory to build compounding workplace knowledge. | $500K / Pre-Seed / Jun 16, 2026 | ||
| See all 242 investments → | |||
Co-Investors
About Y Combinator
Y Combinator invests a standard amount of capital in exchange for equity and through uncapped safe agreements. Participants engage in a three-month intensive cycle that focuses on product development and preparations for fundraising. The firm offers access to a private networking platform for knowledge sharing and hosts events featuring speakers from various sectors. This program culminates in a presentation event where founders showcase their businesses to a curated group of investors.
Y Combinator Contacts
| Name | Phone | Socials | |
|---|---|---|---|
Boris Jabes
Visiting Partner
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Luther Lowe
Head of Public Policy
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Max Kolysh
Visiting Partner
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Brad Flora
Group Partner
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Calvin French-Owen
Visiting Group Partner
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FAQ
What does Nicolas Dessaigne invest in?
Nicolas Dessaigne invests primarily in Artificial Intelligence, Software and SaaS startups, most often at Pre-Seed and Seed stage. Most of the 242 investments tracked by Shizune back companies in United States. The Investment Focus section breaks down every industry, stage and country in the portfolio.
What round sizes does Nicolas Dessaigne invest in?
Nicolas Dessaigne typically joins rounds of $1.6M–$10M at Seed, $500k–$647k at Pre-Seed and $8M–$25M at Series A. These are whole funding-round sizes, not Nicolas Dessaigne's own check, which is rarely disclosed: the 10th–90th percentile of the confirmed public funding rounds Nicolas Dessaigne took part in.
How do I contact Nicolas Dessaigne?
Public channels for Nicolas Dessaigne include LinkedIn, X (Twitter) and the website linked on this profile. For a verified work email and phone number, create a free Shizune account — contact data is searched across 20+ sources and validated before delivery, so your outreach lands in the right inbox.
When did Nicolas Dessaigne last invest?
The most recent investment recorded for Nicolas Dessaigne closed in Sep 2026. Shizune tracks 242 investments in total for this profile, including round sizes, stages and portfolio companies, all sourced from confirmed public funding rounds and refreshed monthly.
Is Shizune's investor data accurate?
Yes — every stat on this profile is calculated from confirmed public funding rounds monitored across hundreds of sources since 2020. This profile was last refreshed in Oct 2026 and is updated monthly. Spotted something off? Use the “Suggest an edit” link near the top of the page.
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