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Main Sequence Ventures, VC Fund

Main Sequence Ventures

VC Fund

Sydney, Australia

Main Sequence Ventures is a VC fund in Sydney focused on Software and Artificial Intelligence. Main Sequence Ventures invests in ambitious founders creating the next set of global industries leveraging deep tech or frontier technologies. The firm is backed by the Australian National Science Agency, CSIRO, the Australian Federal Government, and private investors. All Main Sequence investments leverage world-leading research from Australianpublic research organizations such as CSIRO, any of Australia's 41 universities or its multitude of other industry research agencies.

Total investments:
135
Last investment:
Lead investor:
41%
Fund size:
$305M
Last fund:

Last updated:

Industries Main Sequence Ventures invests in

SoftwareArtificial IntelligenceManufacturingInformation TechnologyBiotechnology

Stages Main Sequence Ventures invests in

SeedSeries ASeries BFunding RoundPre-Seed

Countries Main Sequence Ventures invests in

AustraliaUnited StatesPhilippines

Round sizes

Seed $1M–$7MSeries A $4.8M–$30MSeries B $14M–$72M

Contacts

NameEmailPhoneSocials
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Round size

Seed
$1M–$7M
Series A
$4.8M–$30M
Series B
$14M–$72M

Investment Focus

Industry

  • Software 13 (10%)
  • Artificial Intelligence 10 (7%)
  • Manufacturing 7 (5%)
  • Information Technology 7 (5%)
  • Biotechnology 6 (4%)
See all 83 industries →

Stage

  • Seed 32 (24%)
  • Series A 27 (20%)
  • Series B 17 (13%)
  • Funding Round 14 (10%)
  • Pre-Seed 4 (3%)
See all 7 stages →

Country

  • Australia 53 (39%)
  • United States 4 (3%)
  • Philippines 3 (2%)

Team

NameTitleInvestmentsLinksEmail
Mike Zimmerman
Mike Zimmerman Partner
Partner Total investments: 18
Find email
Phil Morle
Phil Morle Partner
Partner Total investments: 21
Find email
Alezeia Brown
Alezeia Brown Investment Manager
Investment Manager Total investments: 5
Find email
Bill Bartee
Bill Bartee Partner
Partner Total investments: 27
Find email
Jun Qu
Jun Qu Deep tech VC
Deep tech VC Total investments: 2
Find email
See all 7 team members →

Investments

CompanyDescriptionRoundLinks
Metacognition Metacognition
Metacognition is an artificial intelligence company dedicated to building the next generation of intelligent AI agents and robotic software platforms. The company's core mission is to solve the problem of persistent memory and lifelong reasoning in always-on, multi-agent systems. $7.2M / Pre-Seed / Sep 09, 2026
Facet Amtech Facet Amtech
Facet Amtech develops and produces ammonia from water and air. $2.2M / Seed / Aug 26, 2026
Facet Amtech Facet Amtech
Facet Amtech develops and produces ammonia from water and air. $2.2M / Seed / Aug 26, 2026
Zabidou Zabidou
Zabidou develops laser-based sensing systems that give machines real-time perception to separate materials and improve sorting efficiency. $2.5M / Seed / Aug 04, 2026
Emesent Emesent
Emesent is a venture-backed technology company that automates the collection and analysis of critical data in challenging underground environments. Our flagship product is the award-winning Hovermap; a LiDAR-mapping and autonomy payload for industrial drones. Hovermap allows drones to fly and map in GPS-denied environments such as undergroundmines.Through Hovermap and other solutions, we deliver revolutionary efficiency, safety and operational insights to underground mines and other GPS-denied environments. Our growing team of experienced roboticists and engineers are dedicated to creating cutting-edge drone autonomy and data analytics for industrial applications. $10.4M / Convertible Note / Jul 02, 2026
Arkeus Arkeus
Arkeus specializes in the quick design, creation, and production of autonomous optical capabilities for Search, Intelligence, Surveillance, and Reconnaissance (SISR). $17.9M / Series A / May 15, 2026
DeteQt DeteQt
Semiconductor chip-based quantum magnetic field sensors using diamond - navigation, mining, medical imaging $3.5M / Seed / Apr 14, 2026
Cauldron Ferm Cauldron Ferm
Cauldron Ferm is a bio-acceleration process that exponentially scales up any precision fermented prototype to commercial quantities faster and with a lower cost of goods than any traditional production method. $13.3M / Series A / Mar 24, 2026
Arlula Arlula
Arlula provides the infrastructure and single access point that allows users to procure, manage and process satellite imagery at scale. Founded in 2018, Arlula aims to connect the value of Earth observation data from orbit to people and businesses on the ground. Our automation technology, ML tasking scheduler, and partnerships with global satelliteoperators, Government and research institutions, and technology companies to create the infrastructure that fuels the growth of the EO industry. Arlula is changing this by providing the infrastructure which will enable anyone to monitor our planet from space. $2.4M / Seed / Mar 24, 2026
Advanced Navigation Advanced Navigation
Advanced Navigation is a privately owned Australian company that specializes in the development of navigation technologies and robotics. The company has a focus on generating products of the highest quality standard, both in terms of hardware and software. The company's founders came from a background in mission critical robotics built tomilitary specifications and this can be seen through Advanced Navigation's products. Advanced Navigation's engineers have specialized expertise across a broad range of fields including sensors, GNSS, inertial navigation, RF technologies, acoustics, robotics, AI, and algorithms. $111.9M / Series C / Mar 17, 2026
See all 135 investments →

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FAQ

What does Main Sequence Ventures invest in?

Main Sequence Ventures invests primarily in Software, Artificial Intelligence and Manufacturing startups, most often at Seed and Series A stage. Most of the 135 investments tracked by Shizune back companies in Australia. The Investment Focus section breaks down every industry, stage and country in the portfolio.

What is Main Sequence Ventures's check size?

Main Sequence Ventures typically joins rounds of $1M–$7M at Seed, $4.8M–$30M at Series A and $14M–$72M at Series B. These ranges are 10th–90th percentile round sizes calculated from confirmed public funding rounds, so they are a realistic guide to the rounds Main Sequence Ventures participates in.

How do I contact Main Sequence Ventures?

Public channels for Main Sequence Ventures include LinkedIn, X (Twitter) and the website linked on this profile. For a verified work email and phone number, create a free Shizune account — contact data is searched across 20+ sources and validated before delivery, so your outreach lands in the right inbox.

Who are the partners at Main Sequence Ventures?

The team at Main Sequence Ventures includes Mike Zimmerman (Partner), Phil Morle (Partner) and Alezeia Brown (Investment Manager), among 7 team members tracked by Shizune. The Team section lists each member with their title, investment count and links.

Is Shizune's investor data accurate?

Yes — every stat on this profile is calculated from confirmed public funding rounds monitored across hundreds of sources since 2020. This profile was last refreshed in Sep 2026 and is updated monthly. Spotted something off? Use the “Suggest an edit” link near the top of the page.

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