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Lorenzo Thione, Managing Director at Gaingels

Lorenzo Thione

Managing Director @ Gaingels

Manhattan, United States

Lorenzo Thione is a seed investor at Gaingels in Manhattan focused on Software and Artificial Intelligence. Lorenzo Thione is the co-founder of Powerset, Inc., an innovative search startup founded in 2005, with the vision of bringing to consumers a more natural and effective type of Internet search than conventional keyword search. Funded by notable Silicon Valley VCs and angel investors, Powerset was acquired by Microsoft Corp. in 2008 to complement andinnovate on its own search technology and offering. Currently, he is a Principal Program Manager in charge of the Powerset division of Bing, Microsoft's innovative "Decision Engine". Lorenzo is an active angel investor, board member and advisor in several startup, including Dolores Labs, an exciting and energetic San Francisco startup building a scalable platform for human-based computing and crowdsourcing, Crowdflower, and several others at various stages, in the US and abroad, like Kidlandia, Etacts, 8Coupons, and iBrii. In addition to his Internet-tech endeavors, Lorenzo is a theater producer currently busy in bringing several new works to the Broadway stage, including the recently emerging Green Day musical, American Idiot of which he's Associate Producer. His current and most ambitious project is a brand new musical bound for the Broadway stage. Jay Kuo's original musical Allegiance, starring George Takei and Lea Salonga, follows the story of a Japanese American family during the years of the WWII Japanese American internment, and is currently aiming for a 2012 Broadway debut.Lorenzo is a founding board member of StartOut (www.startout.org), a non-profit organization dedicated to fostering and developing entrepreneurship within the LGBT community, and during his service on the board of StartOut, the non-profit, founded in 2009, has grown to a membership of over 1000 individuals nationwide and three active chapters in New York, San Francisco and Los Angeles, with plans for faster growth. He serves on the board of trustees of the American Conservatory Theatre in San Francisco, and Reason To Party, a SF-based non-profit dedicated to improving the lives of underserved Bay Area residents by raising money for charity groups through events held in collaboration with local businesses. A native of Milan, Italy, Lorenzo moved to Austin, Texas at age 21, to complete his studies at the University of Texas at Austin, from which he holds a M.S. in Computer Engineering, and has co-authored several publications in Software Engineering and Computational Linguistics. He is a named inventor on 10 issued and over 20 pending patents in the US and world-wide.

Total investments:
46
Last investment:
Lead investor:
2%

Last updated:

Industries Lorenzo Thione invests in

SoftwareArtificial IntelligenceSaaSSecurityMachine Learning

Stages Lorenzo Thione invests in

SeedPre-SeedSeries ASeries DSeries B

Countries Lorenzo Thione invests in

United StatesGermanyUnited Kingdom

Round sizes

Seed $1.2M–$11MPre-Seed $535k–$3.3MSeries A $5M–$30M

Contacts

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Round size

Seed
$1.2M–$11M
Pre-Seed
$535k–$3.3M
Series A
$5M–$30M

Investment Focus

Industry

  • Software 17 (37%)
  • Artificial Intelligence 7 (15%)
  • SaaS 4 (9%)
  • Security 4 (9%)
  • Machine Learning 4 (9%)
See all 104 industries →

Stage

  • Seed 19 (41%)
  • Pre-Seed 7 (15%)
  • Series A 5 (11%)
  • Series D 3 (7%)
  • Series B 2 (4%)
See all 11 stages →

Country

  • United States 34 (74%)
  • Germany 1 (2%)
  • United Kingdom 1 (2%)

Investments

CompanyDescriptionRoundLinks
Ashby is a developer of recruitment software used for high-growth companies. It develops usable, enterprise-grade employment software that enables company leaders, recruiters, and hiring managers to run their hiring process significantly better. It was founded in 2018 and is based in San Francisco, California. $50M / Series D / Jul 22, 2025
Turing.com connects world-class remote software engineers with world-class companies. 200+ companies, including those backed by Google Ventures, Andreessen, Founders Fund, Kleiner, and Bloomberg, have hired Turing developers. Over 1M+ developers from across 150+ countries have chosen Turing as their preferred platform for landing remote jobs. $111M / Series E / Mar 06, 2025
Openmart Openmart
AI agent that automates B2B sales for brands and manufacturers. $2.8M / Seed / Aug 21, 2024
Ceemo uses Crunchbase data & strategy-based algorithms to automate the brand creation process, then seamlessly applies your new brand across marketing materials required to launch, run, and grow your SMBs, startups, non-profits, and more. We're the data-backed, automated on-ramp for creative marketing, helping you grow & get fundedfaster. $1M / Pre-Seed / Jun 20, 2024
Limbic provides psychological therapies to adults. They enable psychological therapy. They specialize in providing AI software for mental healthcare. They also provide medical devices to support referrals and clinical assessments in psychological therapy. $14M / Series A / Mar 05, 2024
Build powerful AI workflows in minutes. $1.4M / Seed / Jan 09, 2024
SpecCheck, backed by Y Combinator (W23), is an all-in-one solution that provides accurate prescription eyewear ordering and tracking, seamless billing, and streamlined communication between patients, eye doctors, and their lab partners. SpecCheck’s users work more efficiently and make fewer costly errors, increasing productivity and improving theiroverall workflow.Get in touch today for a product demo and to learn more! $3.7M / Seed / Oct 04, 2023
Paxton AI is an innovative legal tech company that utilizes cutting-edge Generative AI technology to revolutionize the way legal and compliance professionals work. Our robust AI platform ingests vast sources of regulatory information, including all state and federal laws and regulations, and provides precise, relevant, and insightful responses touser queries. From answering questions about regulations to drafting legal documents, Paxton AI transforms the legal research and analysis process, saving time and increasing efficiency. $6M / Seed / Sep 19, 2023
Better Brand is a food tech startup using proprietary formulations and tech-enabled processes alongside real, clean label ingredients to lead innovation in the multi-trillion-dollar refined carb industry, $6M / Series A / Jun 21, 2023
Zamp is the sales tax technology provider of solution that eliminates the need for you to manage the software. $4M / Seed / May 10, 2023
See all 46 investments →

Co-Investors

Gaingels

About Gaingels

VC Fund · New York, United States

Gaingels is a venture investment syndicate in service of the LGBT+ community and its allies, investing in companies with LGBT+ founders and C-suite leaders at all stages of growth, as well as in more established companies resolved on building more inclusive teams, with a global portfolio of 130+ companies and $70M in deployed investment capital todate. The Gaingels network also actively supports its portfolio in identifying and recruiting diverse talent to their C-suite and board leadership teams and fosters a vibrant global community of industry leaders, investors, operators, and entrepreneurs who share a common goal for positive social change through business and successful investments.

Gaingels Contacts

NameEmailPhoneSocials
Alexandra Tanner
Alexandra Tanner Investor
Andrew Chen
Andrew Chen Investor
Brandon Parkes
Brandon Parkes Head of Corporate Board Diversity Program
Chris Leiter
Chris Leiter Venture Partner & Investor
David Beatty
David Beatty Managing Members

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FAQ

What does Lorenzo Thione invest in?

Lorenzo Thione invests primarily in Software, Artificial Intelligence and SaaS startups, most often at Seed and Pre-Seed stage. Most of the 46 investments tracked by Shizune back companies in United States. The Investment Focus section breaks down every industry, stage and country in the portfolio.

What is Lorenzo Thione's check size?

Lorenzo Thione typically joins rounds of $1.2M–$11M at Seed, $535k–$3.3M at Pre-Seed and $5M–$30M at Series A. These ranges are 10th–90th percentile round sizes calculated from confirmed public funding rounds, so they are a realistic guide to the rounds Lorenzo Thione participates in.

How do I contact Lorenzo Thione?

Public channels for Lorenzo Thione include LinkedIn, X (Twitter) and the website linked on this profile. For a verified work email and phone number, create a free Shizune account — contact data is searched across 20+ sources and validated before delivery, so your outreach lands in the right inbox.

When did Lorenzo Thione last invest?

The most recent investment recorded for Lorenzo Thione closed in Jul 2025. Shizune tracks 46 investments in total for this profile, including round sizes, stages and portfolio companies, all sourced from confirmed public funding rounds and refreshed monthly.

Is Shizune's investor data accurate?

Yes — every stat on this profile is calculated from confirmed public funding rounds monitored across hundreds of sources since 2020. This profile was last refreshed in Aug 2026 and is updated monthly. Spotted something off? Use the “Suggest an edit” link near the top of the page.

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