Lee Shapiro
Co-Founder & Managing Partner @ 7wire Ventures
Chicago, United States
Lee Shapiro is a Series A investor at 7wire Ventures in Chicago focused on Health Care and Medical. Lee Shapiro is Managing Partner at 7wire Ventures, an investment firm he co-founded over a decade ago. He serves on the boards of Medidata Solutions [NASDAQ:MDSO], Tivity Health [NASDAQ:TVTY], and Aptus Health (f/k/a Physicians Interactive Holdings, a Merck subsidiary [NYSE:MRK]). He is also active with the 7wire portfolio and serves onthe boards of Livongo Health, Ayogo Health, Carebox, Zest Health (Chairman), Modern Teacher (past Chairman), and Education Funding Partners.As President of Allscripts [NASDAQ:MDRX] from 2001 through 2012, his leadership was central to over $4B in mergers, acquisitions and financings. He oversaw the company's strategy, international operations, business development and partnerships, health plan initiatives and entrepreneurial business investments.He is a member of the Northwestern’s Kellogg Innovation Network Advisory Board, the University of Chicago Innovation Fund Advisory Committee, The Qualcomm Life Advisory Council and is on the advisory board for the Center of Digital Innovation in Health in Beer-Sheva, Israel.Lee is a member of the National Board of Directors of the American Heart Association. He has also served as an officer and director of the Gastro-Intestinal Research Foundation (GIRF), where he is now on the advisory board. Lee earned his JD degree from The University of Chicago Law School and a BS in Accounting from The University of Illinois Urbana-Champaign.
- Total investments:
- 26
- Last investment:
- Lead investor:
- 42%
Last updated:
For AI agents: llms.txt
Industries Lee Shapiro invests in
Stages Lee Shapiro invests in
Countries Lee Shapiro invests in
Investment Focus
Industry
- Health Care 15 (58%)
- Medical 8 (31%)
- Wellness 6 (23%)
- Artificial Intelligence 4 (15%)
- Health Diagnostics 3 (12%)
Stage
- Series A 9 (35%)
- Seed 6 (23%)
- Series B 5 (19%)
- Series C 2 (8%)
- Series D 2 (8%)
Country
- United States 15 (58%)
- Canada 1 (4%)
Investments
| Company | Description | Round | Links |
|---|---|---|---|
Karoo Health
|
Karoo Health is a leader in tech-enabled value-based cardiovascular care solutions and aims to bring innovative, end-to-end, cardiovascular solutions to patients via partnerships with health plans and self-insured employers. As a patient-first organization, Karoo Health’s mission is to help patients lead their best lives by providing a new paradigmof better cardiology care, at lower cost, than the current system and preventing the progression of cardiovascular disease. | $16.2M / Series A / Jul 20, 2026 | |
Hippocratic AI
|
Hippocratic AI’s Aim is to develop the safest artificial Health General Intelligence (HGI). greatly enhance healthcare access and boost the scalability of healthcare professionals using the safest artificial Health General Intelligence (HGI), resulting in a more fair system of care for all. | $17M / Series A / Sep 19, 2024 | |
PayZen
|
PayZen is a healthcare fintech startup that aims to tackle the growing patient payment responsibility problem. The mission-driven company together with its superior technology and a new approach enables patients to pay their out-of-pocket medical bills over time with convenience and transparency. While Medical Providers should be able to focus onproviding healthcare services rather than financial services. The company achieves better financial outcomes for both patients and providers through Smart Medical Payment Plans And Non-Recourse Patient Financing.Ariel Rosenthal, Itzik Cohen, and Tobias Mezger co-founded the company in San Francisco, California in 2019. | $32M / Series B / Aug 13, 2024 | |
Transcarent
|
Transcarent is a consumer-directed health and care platform for employees of self-insured employers and their families. Using a combination of software, technology, health guides, and data science, the company helps consumers with unbiased information, trusted guidance, and access to high-value care. | $126M / Series D / May 02, 2024 | |
Caraway
|
Caraway is a digital healthcare company for college women+ that provides integrated mental, reproductive and physical healthcare services. Built with students for students, Caraway arms women+ with the first personalized, equitable and digitally-accessible care solution that prioritizes their needs and concerns. With an unprecedented need formental health resources and new barriers and persistent inequities in women’s+ health, Caraway provides access to trusted, holistic, and compassionate healthcare so women+ can get the care they need when they need it. | $16.8M / Series A / Jun 20, 2023 | |
Override
|
With Override, we pair each patient with a virtual, interdisciplinary care team that really discusses how to help patients improve and overcome hurdles to advancement. | $3.5M / Seed / Dec 15, 2022 | |
|
PayZen
|
PayZen is a healthcare fintech startup that aims to tackle the growing patient payment responsibility problem. The mission-driven company together with its superior technology and a new approach enables patients to pay their out-of-pocket medical bills over time with convenience and transparency. While Medical Providers should be able to focus onproviding healthcare services rather than financial services. The company achieves better financial outcomes for both patients and providers through Smart Medical Payment Plans And Non-Recourse Patient Financing.Ariel Rosenthal, Itzik Cohen, and Tobias Mezger co-founded the company in San Francisco, California in 2019. | $20M / Series B / Nov 15, 2022 | |
Folx Health
|
Folx Health is a telehealth platform that provides digital healthcare services designed for the LGBTQIA+ community. The platform builds a medical service marketplace tailored toward the queer community. It combines access to a specialized network of queer and trans clinicians with a tailored focus on clinical offerings that are typicallymarginalized in traditional health settings. The startup focuses on providing patients with gender-affirming hormone therapy, sexual health, and family creation services.Folx Health was launched in 2020 and is based in Boston, Massachusetts, United States. | $30M / Series B / Oct 12, 2022 | |
Homeward
|
Homeward is rearchitecting rural health and care for the 60 million Americans living in rural communities. Homeward employs a multidisciplinary care team, available both virtually and on the ground via mobile care units, with in-home remote monitoring to better connect patients to high-quality, affordable, and comprehensive care. Today, the companypartners with Medicare Advantage plans, taking on the full risk of their members to improve outcomes and reduce costs. | $50M / Series B / Aug 03, 2022 | |
|
Caraway
|
Caraway is a digital healthcare company for college women+ that provides integrated mental, reproductive and physical healthcare services. Built with students for students, Caraway arms women+ with the first personalized, equitable and digitally-accessible care solution that prioritizes their needs and concerns. With an unprecedented need formental health resources and new barriers and persistent inequities in women’s+ health, Caraway provides access to trusted, holistic, and compassionate healthcare so women+ can get the care they need when they need it. | $10.5M / Seed / Jul 26, 2022 | |
| See all 26 investments → | |||
Co-Investors
About 7wire Ventures
7wire ventures focuses on investing in early and growth-stage companies focused on healthcare IT, digital healtcare and mobile health.
7wire Ventures Contacts
| Name | Phone | Socials | |
|---|---|---|---|
|
Lee Shapiro
Co-Founder & Managing Partner
|
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Robert Garber
Managing Partner
|
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Alyssa Jaffee
Partner
|
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David Schonthal
Operating Partner
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Glen Tullman
Co-Founder & Managing Partner
|
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FAQ
What does Lee Shapiro invest in?
Lee Shapiro invests primarily in Health Care, Medical and Wellness startups, most often at Series A and Seed stage. Most of the 26 investments tracked by Shizune back companies in United States. The Investment Focus section breaks down every industry, stage and country in the portfolio.
When did Lee Shapiro last invest?
The most recent investment recorded for Lee Shapiro closed in Jul 2026. Shizune tracks 26 investments in total for this profile, including round sizes, stages and portfolio companies, all sourced from confirmed public funding rounds and refreshed monthly.
Is Shizune's investor data accurate?
Yes — every stat on this profile is calculated from confirmed public funding rounds monitored across hundreds of sources since 2020. This profile was last refreshed in Aug 2026 and is updated monthly. Spotted something off? Use the “Suggest an edit” link near the top of the page.
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