# NSF Small Business Innovation Research / Small Business Technology Transfer (SBIR/STTR)

> NSF Small Business Innovation Research / Small Business Technology Transfer (SBIR/STTR) is a VC fund backing Health Care. See 82 investments, check sizes…

- Type: VC Fund
- Location: Arlington, United States
- Total investments: 82
- Last investment: Oct 2025
- Lead investor: 71%
- Last updated: Aug 2026
- LinkedIn: https://www.linkedin.com/company/national-science-foundation-sbir-sttr/
- X (Twitter): https://www.twitter.com/nsf
- Website: https://www.nsf.gov/eng/iip/sbir/home.jsp
- Facebook: https://www.facebook.com/us.nsf

NSF Small Business Innovation Research / Small Business Technology Transfer (SBIR/STTR) is a VC fund in Arlington focused on Health Care and Biotechnology. The NSF Small Business Innovation Research (SBIR)/Small Business Technology Transfer (STTR) program encourages the submission of innovative proposals that show promise of commercial and societal impact in almost all areas of technology (except drug development). Proposals should be driven by market and societal needs and opportunities, andshould identify both the end users of the proposed technology and the proposed pathway to commercialization.The NSF Small Business Innovation Research / Small Business Technology Transfer (SBIR/STTR) program seeks to transform scientific discovery into societal and economic benefit by catalyzing private sector commercialization of technological innovations. The program increases the incentive and opportunity for startups and small businesses to undertake cutting-edge, high-quality scientific research and development.They provide grants in phases: a proof-of-concept / feasibility grant (6-12 months, $225k) can potentially be followed by a longer development grant (2 years, $750k).

## Contacts

5 contacts available for NSF Small Business Innovation Research / Small Business Technology Transfer (SBIR/STTR). Shizune tracks 1 team members at NSF Small Business Innovation Research / Small Business Technology Transfer (SBIR/STTR). Sign up free to unlock them: https://app.shizune.co/sign-up/investor-profiles/find-team-emails/nsf-small-business-innovation-research-small-business-technology-transfer-sbir-sttr?utm_source=investor_profile

## Investment focus

### Industry

| Industry | Investments | Share |
| --- | --- | --- |
| Health Care | 14 | 17% |
| Biotechnology | 10 | 12% |
| Software | 9 | 11% |
| Medical Device | 8 | 10% |
| Information Technology | 7 | 9% |

86 industries tracked in total.

### Stage

| Stage | Investments | Share |
| --- | --- | --- |
| Grant | 44 | 54% |
| Pre-Seed | 4 | 5% |
| Seed | 3 | 4% |
| Angel | 1 | 1% |

## Team

| Name | Title | Investments | Profile |
| --- | --- | --- | --- |
| F. Fleming Crim | CEO | 0 | — |

## Investments

| Company | Description | Amount | Stage | Date | Website |
| --- | --- | --- | --- | --- | --- |
| Myrias Optics | Myrias Optics offers a comprehensive variety of services that lead to low-cost full-scale manufacture. Provide a template or "master" and Myrias will do an initial scale-up demonstration to back out crucial information about material and process dependencies. | $1.5M | Grant | Oct 10, 2025 |  |
| Encapsulate | Producing an effective chemotherapy solution with a fully automated tumor-on-a-chip, pre-prescription analysis. | $1.3M | Grant | Aug 01, 2025 |  |
| GIANT BioSystems | GIANT BioSystems is a developer of an ultra-fast, next-generation platform for AST and high-throughput drug screening. | $305K | Grant | Mar 01, 2025 |  |
| GeniPhys | GeniPhys is a medical technology company that plans to develop and commercialize its patented technology. The company was founded in 2014 and is based in Zionsville, Indiana. | $500K | Grant | Oct 22, 2024 |  |
| Silvis Materials | Silvis Materials develops 100% bio-renewable, bio-degradable cellulose emulsions will enable companies to create cradle-to-grave packaging, making coatings and glues without petroleum-derived materials, while cleaning up Air, Water and Land pollution. Silvis' emulsions will: use cellulose to create Recyclable; Compostable, Biodegradable (RCB)emulsions; match petroleum-based emulsion price, and plug into existing manufacturing; achieve global emissions regulations, dispensing with expensive legal challenges; reduce water, air, and land pollution; accelerate corporate sustainability goals | $1M | Grant | Sep 18, 2024 |  |
| Actualization.AI | Chatbot confidence. Actualization.AI specializes in chatbot security, developing a platform that seeks to break chatbots faster than anyone else. This allows them efficiently finding vulnerabilities in chatbots and LLM-based AI systems so that they can be patched, and so you can be confident that the chatbots will behave as they're supposedto. | $275K | Pre-Seed | Sep 01, 2024 |  |
| WiLO Networks | WiLO Networks is developing a revolutionary low-power sensor network platform that leverages wake-up radio technology to enable continuous, low-latency communication while significantly extending battery life and reducing electronic waste. This innovation aims to enhance sustainability and economic growth by making sensor deployments more feasiblein challenging environments and diverse Internet of Things (IoT) applications, with potential impacts across industries such as warehousing, healthcare, and retail. | $1M | Grant | Aug 02, 2024 |  |
| Quarksen | Quarksen develops eQuanta, a creative sensing technology for accessible, accurate, and quick at-home diagnostics. |  | Grant | Jul 11, 2024 |  |
| EarthEn | EarthEn works on technology to provide a carbon-negative, climate-positive long-duration energy storage solution. |  | Grant | Jul 09, 2024 |  |
| gotLearning | gotLearning is the creator of LearningPulse, an AI-powered Student Learning Analysis (SLA) platform built to help educators and administrators make sense of large volumes of student work.Designed by teachers and supported by the National Science Foundation, LearningPulse uses generative AI and NLP to analyze student writing (typed andhandwritten), lab reports, projects, essays, and student reflections across classrooms, schools, and districts. Unlike traditional EdTech tools that focus on grading or content delivery, LearningPulse helps educators surface patterns in student understanding, growth, and curriculum alignment, turning qualitative learning evidence into actionable insight.The platform supports real-time analysis of class-wide and individual student learning, helping school leaders answer critical questions such as:• Where are students struggling to meet instructional goals?• Which instructional strategies are producing the most growth?• How does learning progress align with curriculum and standards?LearningPulse integrates into existing workflows and enables educators to upload student work at scale, from essays to handwritten assignments, generating analysis that drives timely instructional decisions.gotLearning is a privately held education technology company co-founded by former classroom teachers - both with entrepreneurial experience with Blackboard and Cluster, with a mission to help every learner grow by giving educators the tools they need to see and support that growth. | $256K | Grant | Jun 21, 2024 |  |

10 of 82 investments shown.

## Co-investors
- National Science Foundation — VC Fund, 3 deals together
- [focal](https://shizune.co/investors/profile/focal-4f67) — VC Fund, 2 deals together
- Colorado Office of Economic Development and International Trade — VC Fund, 1 deal together
- Intuitive Ventures — VC Fund, 1 deal together
- [OnDeck Venture](https://shizune.co/investors/profile/ondeck-venture) — VC Fund, 1 deal together
- Oregon State University — VC Fund, 1 deal together

## Similar investors

### Similar stage
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- [Foundation for Innovation and Technology (FIT)](https://shizune.co/investors/profile/foundation-pour-l-innovation-technologique) — VC Fund
- [Business Finland](https://shizune.co/investors/profile/tekes) — VC Fund

## FAQ

### What does NSF Small Business Innovation Research / Small Business Technology Transfer (SBIR/STTR) invest in?

NSF Small Business Innovation Research / Small Business Technology Transfer (SBIR/STTR) invests primarily in Health Care, Biotechnology and Software startups, most often at Grant and Pre-Seed stage. Most of the 82 investments tracked by Shizune back companies in United States. The Investment Focus section breaks down every industry, stage and country in the portfolio.

### How do I contact NSF Small Business Innovation Research / Small Business Technology Transfer (SBIR/STTR)?

Public channels for NSF Small Business Innovation Research / Small Business Technology Transfer (SBIR/STTR) include LinkedIn, X (Twitter) and the website linked on this profile. For a verified work email and phone number, create a free Shizune account — contact data is searched across 20+ sources and validated before delivery, so your outreach lands in the right inbox.

### Who are the partners at NSF Small Business Innovation Research / Small Business Technology Transfer (SBIR/STTR)?

The team at NSF Small Business Innovation Research / Small Business Technology Transfer (SBIR/STTR) includes F. Fleming Crim (CEO). The Team section lists each member with their title, investment count and links.

### Is Shizune's investor data accurate?

Yes — every stat on this profile is calculated from confirmed public funding rounds monitored across hundreds of sources since 2020. This profile was last refreshed in Aug 2026 and is updated monthly. Spotted something off? Use the “Suggest an edit” link near the top of the page.

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