# Main Street Advisors

> Main Street Advisors is a VC fund in Chicago backing Health Care and Internet. See 5 investments, check sizes, portfolio. Updated Aug 2026.

- Type: VC Fund
- Location: Chicago, United States
- Total investments: 5
- Last investment: Sep 2022
- Lead investor: 20%
- Last updated: Aug 2026
- LinkedIn: https://www.linkedin.com/company/mainstreet-advisors-llc
- Website: https://www.mainstreetadv.com

Main Street Advisors is a VC fund in Chicago focused on Health Care and Internet. Main Street Advisors, Inc., an investment and financial advisory company.

## Round sizes

| Stage | Round size |
| --- | --- |
| Series B | $8.2M–$61M |

## Investment focus

### Industry

| Industry | Investments | Share |
| --- | --- | --- |
| Health Care | 3 | 60% |
| Internet | 2 | 40% |
| Information Technology | 2 | 40% |
| iOS | 1 | 20% |
| Sports | 1 | 20% |

15 industries tracked in total.

### Stage

| Stage | Investments | Share |
| --- | --- | --- |
| Series B | 2 | 40% |
| Seed | 1 | 20% |
| Series A | 1 | 20% |
| Series C | 1 | 20% |

## Investments

| Company | Description | Amount | Stage | Date | Website |
| --- | --- | --- | --- | --- | --- |
| Kate Farms | Kate Farms offers nutritionally advanced, plant-based tube feeding, and enteral formulas that are well-tolerated by patients. Free of common allergens, including soy, dairy, and corn, clinicians report patients have experienced decreased symptoms of GI intolerance, improved weight or linear growth, and overall improved nutritional status. KateFarms is now the #1 plant-based enteral formula on the market. They’re gaining a better understanding of the role nutrition has on health, both in the management of care and direct therapeutic impact. Ingredients matter and our formulas are designed to deliver outcomes that matter. They pair leading-edge science and technologies with ingredients from nature in unique formulations that work with the bodies. This combination offers the potential for significant improvements to health and to the practice of healthcare. Today doctors, dietitians, parents, caregivers, and those with medical and dietary needs are empowered with the choice of a new formula. It’s the nourishment that makes them feel good because everyone deserves nothing less. | $75M | Series C | Sep 19, 2022 |  |
| Mahana Therapeutics | Mahana Therapeutics develops digital treatments for people living with chronic health conditions that are designed to provide physical and psychological support that will be clinically proven to help patients feel better. | $61M | Series B | Aug 11, 2021 |  |
| Kate Farms | Kate Farms offers nutritionally advanced, plant-based tube feeding, and enteral formulas that are well-tolerated by patients. Free of common allergens, including soy, dairy, and corn, clinicians report patients have experienced decreased symptoms of GI intolerance, improved weight or linear growth, and overall improved nutritional status. KateFarms is now the #1 plant-based enteral formula on the market. They’re gaining a better understanding of the role nutrition has on health, both in the management of care and direct therapeutic impact. Ingredients matter and our formulas are designed to deliver outcomes that matter. They pair leading-edge science and technologies with ingredients from nature in unique formulations that work with the bodies. This combination offers the potential for significant improvements to health and to the practice of healthcare. Today doctors, dietitians, parents, caregivers, and those with medical and dietary needs are empowered with the choice of a new formula. It’s the nourishment that makes them feel good because everyone deserves nothing less. | $9M | Seed | Jan 01, 2021 |  |
| Hyperice | HyperIce is a recovery and movement enhancement technology company specializing in vibration, percussion, and thermal technology. Its technology is used by the athletes in professional and collegiate training rooms and fitness facilities globally.The company is driven by a mission to provide everyone with the innovative technology in acceleratingrecovery time, preventing injury, and enhancing the body’s ability to move efficiently. HyperIce was founded in 2010 by Anthony Katz. | $47.8M | Series A | Oct 08, 2020 |  |
| Reliacast | Reliacast alone offers the best solution for Webcasting to deliver on its full potential. Their audience measurement, management and control technologies are enabling a whole new breed of compelling Webcasting services. | $8.2M | Series B | Mar 28, 2000 |  |

5 of 5 investments shown.

## Co-investors
- [32 Equity](https://shizune.co/investors/profile/32-equity) — VC Fund, 1 deal together
- [Aliment Capital](https://shizune.co/investors/profile/aliment-capital) — VC Fund, 1 deal together
- [Coefficient Capital](https://shizune.co/investors/profile/coefficient-capital) — VC Fund, 1 deal together
- [GERBER-RAUTH](https://shizune.co/investors/profile/gerber-rauth) — VC Fund, 1 deal together
- [Goldman Sachs Asset Management](https://shizune.co/investors/profile/goldman-sachs-asset-management) — VC Fund, 1 deal together
- [Gurnet Point Capital](https://shizune.co/investors/profile/gurnet-point-capital) — VC Fund, 1 deal together

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## FAQ

### What does Main Street Advisors invest in?

Main Street Advisors invests primarily in Health Care, Internet and Information Technology startups, most often at Series B and Seed stage. Most of the 5 investments tracked by Shizune back companies in United States. The Investment Focus section breaks down every industry, stage and country in the portfolio.

### What is Main Street Advisors's check size?

Main Street Advisors typically joins rounds of $8.2M–$61M at Series B. These ranges are 10th–90th percentile round sizes calculated from confirmed public funding rounds, so they are a realistic guide to the rounds Main Street Advisors participates in.

### When did Main Street Advisors last invest?

The most recent investment recorded for Main Street Advisors closed in Sep 2022. Shizune tracks 5 investments in total for this profile, including round sizes, stages and portfolio companies, all sourced from confirmed public funding rounds and refreshed monthly.

### Is Shizune's investor data accurate?

Yes — every stat on this profile is calculated from confirmed public funding rounds monitored across hundreds of sources since 2020. This profile was last refreshed in Aug 2026 and is updated monthly. Spotted something off? Use the “Suggest an edit” link near the top of the page.

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