# Jonathan Leff

> Jonathan Leff is a Series A investor at Sofinnova Investments backing Biotechnology and Medical. See 3 investments, check sizes, portfolio. Updated Aug 2026.

- Type: Angel Investor
- Fund: [Sofinnova Investments](https://shizune.co/investors/profile/sofinnova-ventures)
- Location: Menlo Park, United States
- Total investments: 3
- Last investment: Aug 2026
- Lead investor: 33%
- Last updated: Aug 2026
- LinkedIn: https://www.linkedin.com/in/jonathanaleff/

Jonathan Leff is a Series A investor at Sofinnova Investments in Menlo Park focused on Biotechnology and Medical. Jonathan Leff currently works as a Board Member for Axonis Therapeutics. He previously worked at Aerovate Therapeutics as a Board Member. Jonathan Leff attended the University of Pennsylvania.

## Investment focus

### Industry

| Industry | Investments | Share |
| --- | --- | --- |
| Biotechnology | 2 | 67% |
| Medical | 1 | 33% |

### Stage

| Stage | Investments | Share |
| --- | --- | --- |
| Series A | 2 | 67% |
| Series B | 1 | 33% |

## Investments

| Company | Description | Amount | Stage | Date | Website |
| --- | --- | --- | --- | --- | --- |
| Expedition Therapeutics | Expedition Therapeutics operates as an unincorporated association. | $115M | Series B | Aug 05, 2026 |  |
| Expedition Therapeutics | Expedition Therapeutics operates as an unincorporated association. | $165M | Series A | Oct 09, 2025 |  |
| Axonis Therapeutics | Axonis translates breakthrough regeneration research to groundbreaking paralysis therapy, to transform the lives of spinal cord injury patients. | $115M | Series A | Oct 30, 2024 |  |

3 of 3 investments shown.

## Co-investors
- [Dawn Biopharma](https://shizune.co/investors/profile/dawn-biopharma) — VC Fund, 2 deals together
- [Forbion Capital Partners](https://shizune.co/investors/profile/forbion-capital-partners) — VC Fund, 2 deals together
- [Logos Capital](https://shizune.co/investors/profile/logos-capital-6bb8) — VC Fund, 2 deals together
- [Novo Holdings](https://shizune.co/investors/profile/novo-a-s) — VC Fund, 2 deals together
- [Sanofi Ventures](https://shizune.co/investors/profile/sanofi-genzyme-bioventures) — VC Fund, 2 deals together
- [Venrock](https://shizune.co/investors/profile/venrock) — VC Fund, 2 deals together

## About Sofinnova Investments

VC Fund · Menlo Park, United States

Sofinnova Ventures has partnered with entrepreneurs to secure initial funding, build successful teams, win key customers, and navigate acquisitions and IPOs. Sofinnova Ventures invests in Life Science and Technology start-ups. Their professionals are seasoned business operators, possessing deep domain and investment expertise. They know how to helpentrepreneurs build successful, global businesses.

5 contacts available at Sofinnova Investments.

| Name | Title | Profile |
| --- | --- | --- |
| Jakob Dupont | Executive Partner | https://shizune.co/investors/profile/jakob-dupont-e61e |
| James Healy | General Partner & President | https://shizune.co/investors/profile/james-i-healy |
| Jonathan Leff | Executive Partner, Private Equity | https://shizune.co/investors/profile/jonathan-leff-6bb8 |
| Lesley Weber | San Diego Office Manager & EA | https://shizune.co/investors/profile/lesley-weber |
| Maha Radhakrishnan | Executive Partner | https://shizune.co/investors/profile/maha-radhakrishnan |

## Similar investors

### Similar stage
- [Antler](https://shizune.co/investors/profile/antler-be9c) — VC Fund
- [Alumni Ventures](https://shizune.co/investors/profile/alumni-ventures-group) — VC Fund
- [General Catalyst](https://shizune.co/investors/profile/general-catalyst-partners) — VC Fund

## FAQ

### What does Jonathan Leff invest in?

Jonathan Leff invests primarily in Biotechnology and Medical startups, most often at Series A and Series B stage. Most of the 3 investments tracked by Shizune back companies in United States. The Investment Focus section breaks down every industry, stage and country in the portfolio.

### When did Jonathan Leff last invest?

The most recent investment recorded for Jonathan Leff closed in Aug 2026. Shizune tracks 3 investments in total for this profile, including round sizes, stages and portfolio companies, all sourced from confirmed public funding rounds and refreshed monthly.

### Is Shizune's investor data accurate?

Yes — every stat on this profile is calculated from confirmed public funding rounds monitored across hundreds of sources since 2020. This profile was last refreshed in Aug 2026 and is updated monthly. Spotted something off? Use the “Suggest an edit” link near the top of the page.

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