# Intersouth Partners

> Intersouth Partners is a VC fund backing Biotechnology and Health Care. See 144 investments, check sizes, portfolio and contact details. Updated Aug 2026.

- Type: VC Fund
- Location: Durham, United States
- Total investments: 144
- Last investment: Sep 2024
- Lead investor: 24%
- Fund size: $275M
- Last fund: Jan 2006
- Last updated: Aug 2026
- LinkedIn: http://www.linkedin.com/company/intersouth-partners
- X (Twitter): http://twitter.com/intersouth
- Website: http://www.intersouth.com
- Facebook: http://www.facebook.com/pages/Intersouth-Partners/12568563414607

Intersouth Partners is a VC fund in Durham focused on Biotechnology and Health Care. Intersouth Partners is one of the most active and experienced venture funds in the Southeast, having invested in more than 100 private companies over the last three decades. Founded in 1985, Intersouth manages $780 million in seven venture capital limited partnerships, making it the largest venture capital fund in North Carolina and one of thelargest in the Southeast.

## Contacts

5 contacts available for Intersouth Partners. Shizune tracks 8 team members at Intersouth Partners. Sign up free to unlock them: https://app.shizune.co/sign-up/investor-profiles/find-team-emails/intersouth-partners?utm_source=investor_profile

## Round sizes

| Stage | Round size |
| --- | --- |
| Series A | $3M–$17M |
| Series B | $4M–$35M |

## Investment focus

### Industry

| Industry | Investments | Share |
| --- | --- | --- |
| Biotechnology | 27 | 19% |
| Health Care | 23 | 16% |
| Software | 16 | 11% |
| Enterprise Software | 13 | 9% |
| Medical Device | 10 | 7% |

85 industries tracked in total.

### Stage

| Stage | Investments | Share |
| --- | --- | --- |
| Series B | 33 | 23% |
| Series A | 30 | 21% |
| Series C | 24 | 17% |
| Funding Round | 24 | 17% |
| Series D | 11 | 8% |

11 stages tracked in total.

## Team

| Name | Title | Investments | Profile |
| --- | --- | --- | --- |
| Dennis Dougherty | Founder & Managing General Partner | 2 | https://shizune.co/investors/profile/dennis-dougherty |
| John Glushik | Venture Partner | 15 | https://shizune.co/investors/profile/john-glushik |
| Kay Burgess | CFO | 0 | https://shizune.co/investors/profile/kay-burgess |
| Mitch Mumma | Managing General Partner | 4 | https://shizune.co/investors/profile/mitch-mumma |
| Phil Tracy | Venture Partner | 4 | https://shizune.co/investors/profile/phil-tracy |

## Investments

| Company | Description | Amount | Stage | Date | Website |
| --- | --- | --- | --- | --- | --- |
| CSA Medical | CSA Medical provides cryotherapy systems. It offers CryoSpray Ablation system, which enables the physicians to freeze, destroy, and remove unwanted tissues, as well as transports liquid nitrogen that is passed through a standard endoscope. CSA Medical was formerly known as Crymed Technologies and changed its name to CSA Medical in April 2006.Thecompany was incorporated in 1993 and is based in Lutherville Timonium, Maryland. | $53M | Series D | Sep 09, 2024 |  |
| EDJX | EDJX is building the world's largest edge computing platform, an ultra-low latency, decentralized and serverless edge cloud platform that accelerates software development of secure IoT and M2M apps. Content delivery networks (CDN), ojbect storage and DNS. | $12M | Venture - Series Unknown | Aug 08, 2022 |  |
| Advanced Animal Diagnostics | Advanced Animal Diagnostics, Inc. commercializes proprietary technology for the diagnosis of farm-animal diseases. It uses an animal's own immune response to detect and stage infections to improve the quality of life for producers, processors, animals, and consumers. The company offers QuickSmear, a rapid differential slide to speed andsimplify production animal research using differential cell counts; and the SCC+ System for early detection of mastitis. Advanced Animal Diagnostics was founded in 2001 and is based in Durham, North Carolina. | $7M |  | May 11, 2021 |  |
| Advanced Animal Diagnostics | Advanced Animal Diagnostics, Inc. commercializes proprietary technology for the diagnosis of farm-animal diseases. It uses an animal's own immune response to detect and stage infections to improve the quality of life for producers, processors, animals, and consumers. The company offers QuickSmear, a rapid differential slide to speed andsimplify production animal research using differential cell counts; and the SCC+ System for early detection of mastitis. Advanced Animal Diagnostics was founded in 2001 and is based in Durham, North Carolina. | $7M | Series E | May 11, 2021 |  |
| Lyra Therapeutics | Lyra Therapeutics, Inc. is a clinical-stage therapeutics company focused on the development and commercialization of novel integrated drug and delivery solutions for the localized treatment of patients with ear, nose and throat diseases. The company’s proprietary technology platform, XTreo, is designed to precisely and consistently delivermedicines directly to the affected tissue for sustained periods with a single administration. The company’s initial product candidates, LYR-210 and LYR-220, are bioresorbable polymeric matrices designed to be administered in a brief, non-invasive, in-office procedure and intended to deliver up to six months of continuous drug therapy to the sinonasal passages for the treatment of CRS. The therapeutic embedded within LYR-210 and LYR-220 is mometasone furoate, which is the active ingredient in various FDA-approved drugs and has a well-established efficacy and safety profile. | $30M | Series C | Jan 29, 2020 |  |
| CSA Medical | CSA Medical provides cryotherapy systems. It offers CryoSpray Ablation system, which enables the physicians to freeze, destroy, and remove unwanted tissues, as well as transports liquid nitrogen that is passed through a standard endoscope. CSA Medical was formerly known as Crymed Technologies and changed its name to CSA Medical in April 2006.Thecompany was incorporated in 1993 and is based in Lutherville Timonium, Maryland. | $45.2M |  | Feb 07, 2019 |  |
| Lyra Therapeutics | Lyra Therapeutics, Inc. is a clinical-stage therapeutics company focused on the development and commercialization of novel integrated drug and delivery solutions for the localized treatment of patients with ear, nose and throat diseases. The company’s proprietary technology platform, XTreo, is designed to precisely and consistently delivermedicines directly to the affected tissue for sustained periods with a single administration. The company’s initial product candidates, LYR-210 and LYR-220, are bioresorbable polymeric matrices designed to be administered in a brief, non-invasive, in-office procedure and intended to deliver up to six months of continuous drug therapy to the sinonasal passages for the treatment of CRS. The therapeutic embedded within LYR-210 and LYR-220 is mometasone furoate, which is the active ingredient in various FDA-approved drugs and has a well-established efficacy and safety profile. | $29.5M | Series B | Sep 26, 2018 |  |
| Azalea Health | Azalea Health is a leading provider of cloud-based healthcare solutions and services. The complete Azalea solution provides Electronic Health Records (EHR), Practice Management (PM), Revenue Cycle Management (RCM) billing services, as well as Patient Health Records Portal, and a mobile mHealth application. With a focus on patient engagement,Azalea’s integrated solution has the flexibility to accommodate multiple specialties of any size practice and can immediately improve workflow as well as revenue flow. The solution also provides tools and resources to help customers meet their Meaningful Use and ICD-10 requirements | $10.5M | Series B | Jul 15, 2016 |  |
| 6fusion | 6fusion provides an end-to-end cloud management platform that enables global workload distribution by turning the public and private cloud into a pay-per-use billable utility. The unique metering algorithm, Workload Allocation Cube, creates a commercial standard to quantify supply and demand for compute resources. For IT service providers,enterprises and independent software vendors, and Infrastructure Owners/Operators, 6fusion simplifies and streamlines Infrastructure-as-a-Service via a single console that provides valuable insight into consumption, performance benchmarking and cost allocation without vendor lock-in. | $6.6M |  | Mar 25, 2016 |  |
| LocationSmart | LocationSmart® is the worldwide Cloud Location Services market leader for connected devices Based in Carlsbad, CA, LocationSmart is a leading provider of cloud-based location services. This company was founded in 1995 by Masoud Motamedi and Mario Proietti. While it is headquartered in the San Diego area, it has clients based throughout the westernhalf of the United States and around the world. We offer location services for the iGaming Industry. Our location services provide location verification in the Daily Fantasy Sports, Lottery Courier, Online Poker, and Online Casino niches. At LocationSmart, customers can get help with context-aware, local and hyper-local applicant development. This comprehensive, location platform incorporates a device's indoor and outdoor use. It works with multiple carriers, platforms and networks. Some of LocationSmart's customers include Fortune 500 businesses and multinational corporations. Depending on the industry, LocationSmart can help with transportation, roadside services, proximity marketing, financial transaction verification and contact centers. The History Behind LocationSmart Originally, LocationSmart was founded under the name of TechnoCom Corporation in 1995. Its initial goal was to help wireless carriers with their mobile location requirements. Because of its innovative products and services, Deloitte chose TechnoCom as one of the top 50 fastest growing tech companies in Los Angeles for four years in a row. In October 2010, LocationSmart was developed as a division of TechnoCom Corporation. Since it was initially founded, LocationSmart has worked to help people and businesses around the world with location-based services. This company currently has the largest American footprint of any business for location-based services. To make user adoption even easier, the company has pioneered innovative methods for gaining privacy consent. Today, LocationSmart is ranked as the best location-as-a-service provider in the world. Their services are included on 15 billion devices around the world. Every single type of device in the world has the capacity to use LocationSmart, and their technology has been used at least once on every device type before. LocationSmart is used with 2 billion global access points for Wi-Fi and 160 million cell sites.What Can LocationSmart Do? LocationSmart offers a powerful platform for location determination that is designed to be cloud-based. This trusted service helps to raise an organization's business intelligence by delivering additional data, improving the company's operational efficiencies and lowering overall costs. LocationSmart's location-as-a-service platform also helps companies improve their customer engagement and security. It can be used with IP addresses, carriers, landlines and device SDK. Businesses can also use options like LocationSmart's device profile and messaging services. The messaging option allows companies to create geo-enabled SMS, in-app messages and standalone campaigns. The two-way messaging involves complete SMS management that works with more than 60 different carriers. Meanwhile, the device profile option uses the cloud to conduct real-time identity verification and device verification. Because of this, the device profile can help companies validate their returning customers and halt cybercriminals. This technique uses real-time risk scoring and behavior analytics to determine which devices and consumers carry the biggest risk for a company's security. With the geofencing and privacy features, businesses can ensure their clients' privacy and create geo-relevant campaigns. Geofencing helps companies create a radius for providing ads and other services. With LocationSmart's privacy features, businesses can include consent controls and reminders for their users. From advanced reporting requirements to world-class security, LocationSmart offers a variety of services for modern businesses and tech companies. | $2.3M |  | Oct 06, 2015 |  |

10 of 144 investments shown.

## Co-investors
- [Polaris Partners](https://shizune.co/investors/profile/polaris-partners) — VC Fund, 15 deals together
- [Harbert Growth Partners](https://shizune.co/investors/profile/harbert-growth-partners) — VC Fund, 14 deals together
- [The Aurora Funds](https://shizune.co/investors/profile/the-aurora-funds) — VC Fund, 12 deals together
- [Skyline Ventures](https://shizune.co/investors/profile/skyline-ventures) — VC Fund, 10 deals together
- [Noro-Moseley Partners](https://shizune.co/investors/profile/noro-moseley-partners) — VC Fund, 8 deals together
- [North Bridge Venture Partners & Growth Equity](https://shizune.co/investors/profile/north-bridge-venture-partners) — VC Fund, 8 deals together

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## FAQ

### What does Intersouth Partners invest in?

Intersouth Partners invests primarily in Biotechnology, Health Care and Software startups, most often at Series B and Series A stage. Most of the 144 investments tracked by Shizune back companies in United States. The Investment Focus section breaks down every industry, stage and country in the portfolio.

### What is Intersouth Partners's check size?

Intersouth Partners typically joins rounds of $3M–$17M at Series A and $4M–$35M at Series B. These ranges are 10th–90th percentile round sizes calculated from confirmed public funding rounds, so they are a realistic guide to the rounds Intersouth Partners participates in.

### How do I contact Intersouth Partners?

Public channels for Intersouth Partners include LinkedIn, X (Twitter) and the website linked on this profile. For a verified work email and phone number, create a free Shizune account — contact data is searched across 20+ sources and validated before delivery, so your outreach lands in the right inbox.

### Who are the partners at Intersouth Partners?

The team at Intersouth Partners includes Dennis Dougherty (Founder & Managing General Partner), John Glushik (Venture Partner) and Kay Burgess (CFO), among 8 team members tracked by Shizune. The Team section lists each member with their title, investment count and links.

### Is Shizune's investor data accurate?

Yes — every stat on this profile is calculated from confirmed public funding rounds monitored across hundreds of sources since 2020. This profile was last refreshed in Aug 2026 and is updated monthly. Spotted something off? Use the “Suggest an edit” link near the top of the page.

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