# 450 Ventures

> 450 Ventures is a VC fund in Birmingham backing Health Care, Software and Artificial Intelligence. See 5 investments, check sizes, portfolio. Updated Aug 2026.

- Type: VC Fund
- Location: Birmingham, United States
- Total investments: 5
- Last investment: Dec 2025
- Lead investor: 0%
- Last updated: Aug 2026

450 Ventures is a VC fund in Birmingham focused on Health Care and Software. Strategic investment arm of BCBS of Alabama

## Investment focus

### Industry

| Industry | Investments | Share |
| --- | --- | --- |
| Health Care | 5 | 100% |
| Software | 2 | 40% |
| Artificial Intelligence | 2 | 40% |
| Apps | 1 | 20% |
| Mobile | 1 | 20% |

16 industries tracked in total.

### Stage

| Stage | Investments | Share |
| --- | --- | --- |
| Seed | 1 | 20% |
| Pre-Seed | 1 | 20% |
| Series A | 1 | 20% |
| Series C | 1 | 20% |
| Venture - Series Unknown | 1 | 20% |

## Investments

| Company | Description | Amount | Stage | Date | Website |
| --- | --- | --- | --- | --- | --- |
| Codoxo | Codoxo uses AI technology to re-envision healthcare affordability and effectiveness. Its Forensic AI Platform uses a patented algorithm to identify problems and suspicious behavior earlier than traditional techniques which helps ensure our scarce healthcare dollars go to real patient care. It was founded in 2016 and is based in Atlanta, Georgia. | $35M | Series C | Dec 17, 2025 |  |
| Watershed Health | Watershed Health develops a SaaS platform that connects all provider types and health plans. It enables communication, collaboration, and community-wide data sharing for better patient outcomes and reduced costs. | $13.6M | Venture - Series Unknown | May 14, 2024 |  |
| LiveFreely | LiveFreely provides cutting-edge digital health technology solutions that empower seniors and caregivers to take control of aging. Through AI, LiveFreely’s app, BUDDY, monitors, tracks, and alerts seniors, caregivers, and emergency services of critical health issues in real-time. BUDDY fosters a supportive, sustainable ecosystem of healthprofessionals, families, and friends, promoting greater peace-of-mind, security, and well-being for loved ones.BUDDY not only detects health issues in seniors but also predicts and prevents them. Best of all, the system already works on existing consumer devices such as Apple Watch, Fitbit, and Samsung Galaxy. |  | Seed | Jan 01, 2023 |  |
| Carallel | Carallel provides a comprehensive caregiver support solution, MyCareDesk, designed to make caregiving easier and help caregivers reduce the stress of caring for an aging loved one. MyCareDesk is a unique blend of digital tools with personal guidance from trusted senior care experts, so people can manage their caregiving responsibilities all in oneplace. It features information and tools across a wide range of topics and multiple channels. Our goal is to support caregivers at every stage of their journey with valuable resources and access to experienced Care Advocates, so they can spend less time managing and more time caring.Caregiving issues affect both caregivers and their employers. Caregiving impacts 1 in 5 U.S. workers, according to a 2015 AARP report, and the issue is growing. By 2030, the proportion of the U.S. population aged 65+ will double to about 71 million older adults. Caregiving issues drive $50 billion of business loss annually due to things like attrition, lower productivity and increased health care costs. Most individuals and organizations don’t have the resources or expertise to handle these issues on their own.MyCareDesk was designed with the enterprise in mind using a robust and scalable digital platform that is fully customizable. This comprehensive caregiver solution can be used in a variety of organizations including employers, PEOs, Medicare Advantage populations and financial services firms. | $8.2M | Series A | Nov 21, 2022 |  |
| Acclinate | Acclinate is a venture-backed, high-growth company that leverages sustained engagement and AI-driven insights to empower communities to take actions for better health. | $1.4M | Pre-Seed | Apr 01, 2021 |  |

5 of 5 investments shown.

## Co-investors
- [Create Health Ventures](https://shizune.co/investors/profile/create-health-ventures) — VC Fund, 2 deals together
- [FCA Venture Partners](https://shizune.co/investors/profile/fca-venture-partners) — VC Fund, 2 deals together
- [Overline](https://shizune.co/investors/profile/overline-vc) — VC Fund, 2 deals together
- [Wanxiang America Healthcare Investments Group](https://shizune.co/investors/profile/wanxiang-healthcare-investments) — VC Fund, 2 deals together
- [111° West Capital](https://shizune.co/investors/profile/111-west-capital) — VC Fund, 1 deal together
- [Avalanche VC](https://shizune.co/investors/profile/avalanche-vc) — VC Fund, 1 deal together

## Similar investors

### Similar stage
- [Antler](https://shizune.co/investors/profile/antler-be9c) — VC Fund
- [Alumni Ventures](https://shizune.co/investors/profile/alumni-ventures-group) — VC Fund
- [Right Side Capital Management](https://shizune.co/investors/profile/right-side-capital-management) — VC Fund

## FAQ

### What does 450 Ventures invest in?

450 Ventures invests primarily in Health Care, Software and Artificial Intelligence startups, most often at Seed and Pre-Seed stage. Most of the 5 investments tracked by Shizune back companies in United States. The Investment Focus section breaks down every industry, stage and country in the portfolio.

### When did 450 Ventures last invest?

The most recent investment recorded for 450 Ventures closed in Dec 2025. Shizune tracks 5 investments in total for this profile, including round sizes, stages and portfolio companies, all sourced from confirmed public funding rounds and refreshed monthly.

### Is Shizune's investor data accurate?

Yes — every stat on this profile is calculated from confirmed public funding rounds monitored across hundreds of sources since 2020. This profile was last refreshed in Aug 2026 and is updated monthly. Spotted something off? Use the “Suggest an edit” link near the top of the page.

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